Aliases & Classifications for Placenta Accreta

MalaCards integrated aliases for Placenta Accreta:

Name: Placenta Accreta 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4744
ICD10 33 O43.21
MeSH 42 D010921
NCIt 47 C26856
SNOMED-CT 64 70129008
UMLS 69 C0032044

Summaries for Placenta Accreta

Disease Ontology : 12 A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium.

MalaCards based summary : Placenta Accreta is related to cutaneous leishmaniasis and acitretin/etretinate embryopathy. An important gene associated with Placenta Accreta is ANGPT2 (Angiopoietin 2), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Tranexamic Acid and Antifibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and cervix, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 72 Placenta accreta occurs when all or part of the placenta attaches abnormally to the myometrium (the... more...

Related Diseases for Placenta Accreta

Diseases related to Placenta Accreta via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Related Disease Score Top Affiliating Genes
1 cutaneous leishmaniasis 10.5 ANGPT2 TEK
2 acitretin/etretinate embryopathy 10.2 FLT1 PGF
3 colorectal adenoma 10.2 ANGPT1 TEK
4 macular dystrophy, atypical vitelliform 10.2 ANGPT1 ANGPT2
5 idiopathic progressive polyneuropathy 10.2 FLT1 PGF
6 cutaneous mucoepidermoid carcinoma 10.2 ANGPT1 TEK
7 placenta praevia 10.1
8 cervicitis 10.1
9 ulcerative stomatitis 10.1 FLT1 PGF
10 vaginitis 10.0
11 asherman's syndrome 10.0
12 alcohol abuse 10.0 ANGPT2 SERPINB2 SERPINE1
13 neuropathy, hereditary sensory and autonomic, type vi 10.0 ANGPT2 FLT1
14 disseminated intravascular coagulation 9.9
15 uterine inversion 9.9
16 endotheliitis 9.9
17 pyruvate kinase deficiency, muscle type 9.9 ANGPT1 ANGPT2 TEK
18 vesiculobullous skin disease 9.9 KDR TEK
19 3-methylglutaconic aciduria 9.9 CGB3 PGF
20 obstructive jaundice 9.8 FLT1 PGF SERPINE1
21 acute proliferative glomerulonephritis 9.8 FLT1 PGF SERPINE1
22 pleural tuberculosis 9.8 FLT1 PGF SERPINE1
23 kidney pelvis papillary carcinoma 9.8 FLT1 KDR
24 wolff-parkinson-white syndrome 9.8
25 sickle cell anemia 9.8
26 pulmonary hypertension 9.8
27 arteriovenous fistula 9.8
28 chorioamnionitis 9.8
29 thrombosis 9.8
30 gestational diabetes 9.8
31 uterine disease 9.8
32 gestational trophoblastic neoplasm 9.8
33 choriocarcinoma 9.8
34 placental site trophoblastic tumor 9.8
35 trophoblastic neoplasm 9.8
36 syphilis 9.8
37 pulmonary embolism 9.8
38 myotonic dystrophy 9.8
39 limb-body wall complex 9.8
40 partial hydatidiform mole 9.8
41 lens disease 9.7 FLT1 KDR
42 necrotic uveal melanoma 9.7 CGB3 PGF
43 vernal conjunctivitis 9.5 ANGPT2 FLT1 KDR
44 subdural empyema 9.5 FLT1 KDR TEK
45 chikungunya 9.5 FLT1 KDR TEK
46 mitral valve stenosis 9.5 FLT1 KDR
47 coloboma of superior eyelid 9.5 FLT1 KDR PGF
48 preeclampsia/eclampsia 1 9.5 FLT1 PGF SERPINB2 SERPINE1
49 sydenham chorea 9.4 ANGPT1 ANGPT2 FLT1 PGF
50 renal fibrosis 9.4 ANGPT2 KDR PGF TEK

Graphical network of the top 20 diseases related to Placenta Accreta:



Diseases related to Placenta Accreta

Symptoms & Phenotypes for Placenta Accreta

MGI Mouse Phenotypes related to Placenta Accreta:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ANGPT1 ANGPT2 FLT1 KDR PGF SERPINE1
2 growth/size/body region MP:0005378 9.87 ANGPT1 FLT1 KDR PGF SERPINB2 SERPINE1
3 homeostasis/metabolism MP:0005376 9.86 ANGPT1 ANGPT2 FLT1 KDR PGF SERPINB2
4 immune system MP:0005387 9.7 ANGPT1 ANGPT2 FLT1 KDR PGF SERPINB2
5 muscle MP:0005369 9.35 ANGPT1 FLT1 KDR SERPINB2 TEK
6 vision/eye MP:0005391 9.1 ANGPT1 ANGPT2 FLT1 KDR PGF TEK

Drugs & Therapeutics for Placenta Accreta

Drugs for Placenta Accreta (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
2 Antifibrinolytic Agents Phase 4,Phase 3
3 Coagulants Phase 4,Phase 3
4 Hemostatics Phase 4,Phase 3
5
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
6 Anesthetics Phase 3
7 penicillins Phase 3
8 Pharmaceutical Solutions Phase 3
9
Progesterone Approved, Vet_approved 57-83-0 5994
10 Antioxidants
11 Protective Agents
12 acivicin
13 Arginine Vasopressin
14 Vasopressins
15 Estrogens
16 Hormones
17
Creatine Nutraceutical 57-00-1 586

Interventional clinical trials:

(show all 31)

id Name Status NCT ID Phase Drugs
1 Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study Recruiting NCT02806024 Phase 4 Tranexamic Acid;Placebo Drug
2 Tranexamic Acid in Adherent Placenta (TAP) Not yet recruiting NCT02329756 Phase 3 Tranexamic Acid (TXA);Sodium Chloride 0.9%
3 Emergency Peripartum Hysterectomy: A Prospective Study in Iran Completed NCT01285258 Phase 2
4 Correlation Between PIF Maternal Serum Levels and Pregnancy Outcome Unknown status NCT01805102
5 ADAMTS,Proteoglycan and Oxidant / Antioxidant Enzyme Levels of Placenta Previa Totalis (Accreta, Increta, Percreta). Unknown status NCT02270593
6 Placenta Accreta : Contrast-enhanced Ultrasound Analysis in High Risk Population Completed NCT02302573 contast-enhanced ultrasound with sonovue
7 TUI 3D in Diagnosis of Placenta Accreta: Comparison With Gray-scale and Color Doppler Techniques Completed NCT02712099
8 Balloon Catheters in Cases of Abnormal Placentation Completed NCT01373255
9 Efficacy of Prophylactic Internal Iliac Artery Balloon Catheterization in the Management of Placenta Previa and Accreta Completed NCT02966197
10 Long Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure Completed NCT01289262
11 The Placenta Previa and Fetal Weight Completed NCT03321435
12 The Effectiveness of Double Incision Technique in Uterus Preserving Surgery for Placenta Percreta Completed NCT02702024
13 Internal Iliac Artery Ligation and Abnormally Invasive Placenta Completed NCT02728232
14 Optimization of the Healing Process of the Uterine Scar Tissue After Re-cesarean Section Completed NCT02703519
15 Early Prediction of Placenta Accreta by Ultrasound and Color Doppler Recruiting NCT03032770
16 Surgical Technique To Control Postpartum Hemorrhage Recruiting NCT03241849
17 Creatine Kinase Versus 3D Doppler for Antenatal Diagnosis of Abnormal Adherent Placenta. Recruiting NCT03224780
18 Antenatal Diagnosis of Placental Attachment Disorders Recruiting NCT02442518
19 Uterine Cavity and Blood Flow After Conservative Management of Placenta Previa/Accreta Recruiting NCT02878187
20 Predictors of Scar Dehiscence in Patients With Previous Caesarean Section Recruiting NCT03140683
21 The Cervix as a Natural Tamponade in Postpartum Hemorrhage Caused by Placenta Previa and Placenta Previa Accreta Recruiting NCT02590484
22 Clinical Situations at High Risk of Placenta Accreta / Percreta Active, not recruiting NCT02010229
23 Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta Active, not recruiting NCT02784886
24 Use of ROTEM Intraoperatively in Women With Placenta Accreta Enrolling by invitation NCT02729974
25 Ultrasound in Prediction of Operative Findings in Cesarean Section Among Placenta Accreta Cases Not yet recruiting NCT03286998
26 Placenta Accreta&Its Complications in Placenta Previa Cases Not yet recruiting NCT02606474
27 PDIUC Protocol for Placental Accreta Not yet recruiting NCT03273569
28 Transverse B-Lynch in Management of Placenta Accreta Not yet recruiting NCT02943421
29 Bilateral Internal Iliac Artery Ligation Before Cesarean Hysterectomy Not yet recruiting NCT03129035
30 Delivery Timing in Morbidly Adherent Placentas: a Randomized, Controlled Trial Not yet recruiting NCT02635412
31 Fertility Post Placenta Accrete Not yet recruiting NCT02821702

Search NIH Clinical Center for Placenta Accreta

Cochrane evidence based reviews: placenta accreta

Genetic Tests for Placenta Accreta

Anatomical Context for Placenta Accreta

MalaCards organs/tissues related to Placenta Accreta:

39
Placenta, Uterus, Cervix, Endothelial, Testes, Heart

Publications for Placenta Accreta

Articles related to Placenta Accreta:

(show top 50) (show all 512)
id Title Authors Year
1
On opportunity for emergency cesarean hysterectomy and pregnancy outcomes of patients with placenta accreta. ( 28953615 )
2017
2
Prophylactic use of an infrarenal abdominal aorta balloon catheter in pregnancies complicated by placenta accreta. ( 28366073 )
2017
3
Comparison of results of Bakri balloon tamponade and caesarean hysterectomy in management of placenta accreta and increta: a retrospective study. ( 28903630 )
2017
4
Relationship between first trimester aneuploidy screening test serum analytes and placenta accreta. ( 28027672 )
2017
5
Dynamic contrast enhanced MRI of the placenta: A tool for prenatal diagnosis of placenta accreta? ( 28487019 )
2017
6
Cervical varicosities may predict placenta accreta in posterior placenta previa: a magnetic resonance imaging study. ( 28710549 )
2017
7
Catastrophic uterine rupture associated with placenta accreta after previous B-Lynch sutures. ( 28901788 )
2017
8
Acquired uterine arteriovenous fistula due to a previous cornual pregnancy with placenta accreta: A case report. ( 28587344 )
2017
9
Invasive placenta previa: Placental bulge with distorted uterine outline and uterine serosal hypervascularity at 1.5T MRI - useful features for differentiating placenta percreta from placenta accreta. ( 28770405 )
2017
10
Anesthetic management of cesarean section in cases of placenta accreta, with versus without abdominal aortic balloon occlusion: study protocol for a randomized controlled trial. ( 28549439 )
2017
11
Pathologically Diagnosed Placenta Accreta and Hemorrhagic Morbidity in a Subsequent Pregnancy. ( 28079779 )
2017
12
Leaving the placenta in situ versus conservative and radical surgery in the treatment of placenta accreta spectrum disorders. ( 28833092 )
2017
13
Cervical Length in Patients at Risk for Placenta Accreta. ( 28339114 )
2017
14
High-intensity focused ultrasound combined with hysteroscopic resection for the treatment of placenta accreta. ( 28856861 )
2017
15
Intraoperative aortic balloon occlusion in patients with placenta previa and/or placenta accreta: a retrospective study. ( 28420498 )
2017
16
Balloon occlusion of internal iliac arteries in placenta accreta! ( 28442974 )
2017
17
Disseminated intravascular coagulation syndrome two months after conservative management of placenta accreta. About two patients. ( 28689576 )
2017
18
The depletion of MARVELD1 leads to murine placenta accreta via integrin I^4-dependent trophoblast cell invasion. ( 28708243 )
2017
19
Sclerotherapy for placenta accreta: Some concerns. ( 28420525 )
2017
20
Moving from intra partum to prenatal diagnosis of placenta accreta: a quarter of a century in the making but still a long road to go. ( 28009123 )
2017
21
Effect of prophylactic placement of internal iliac artery balloon catheters on outcomes of women with placenta accreta: an impact study. ( 28401537 )
2017
22
Limb Body Wall Complex Associated with Placenta Accreta: A Mere Coincidence or a Sign of an Etiopathogenic Link? ( 28257587 )
2017
23
Accuracy of color Doppler ultrasonography and magnetic resonance imaging in diagnosis of placenta accreta: A survey of 82 cases. ( 28835939 )
2017
24
MRI of Placenta Accreta, Placenta Increta, and Placenta Percreta: Pearls and Pitfalls. ( 27762597 )
2017
25
Placenta accreta spectrum: pathophysiology and evidence-based anatomy for prenatal ultrasound imaging. ( 28599899 )
2017
26
Can venous ProBNP levels predict placenta accreta? ( 26864469 )
2016
27
Attempted placental separation for suspected placenta accreta: experience may matter. ( 26947056 )
2016
28
Escalating placenta invasiveness: repeated placenta accreta at the limit of viability. ( 27143953 )
2016
29
Reply to Letter to the Editor: attempted placental separation for suspected placenta accreta: experience may matter. ( 27061050 )
2016
30
Unusual imaging findings of placenta accreta resulting in early hysterectomy in first trimester-Two case reports. ( 28040150 )
2016
31
Comparison of temporary abdominal aortic occlusion with internal iliac artery occlusion for patients with placenta accreta - a non-randomised prospective study. ( 27598045 )
2016
32
Uterine Artery Embolization for Management of Primary Postpartum Hemorrhage Associated with Placenta Accreta. ( 28065219 )
2016
33
Sclerotherapy with 6% polidocanol solution in patients with placenta accreta. ( 27751411 )
2016
34
Placenta accreta following hysteroscopic myomectomy. ( 27398192 )
2016
35
Prenatal diagnosis of a true umbilical cord knot in a fetus with intrauterine growth restriction and placenta accreta. ( 27590396 )
2016
36
High-intensity focused ultrasound combined with hysteroscopic resection to treat retained placenta accreta. ( 27668209 )
2016
37
Decreased placental and maternal serum TRAIL-R2 levels are associated with placenta accreta. ( 26992667 )
2016
38
Hysterectomy for placenta accreta; methods for gross and microscopic pathology examination. ( 26758078 )
2016
39
Successful Management of Two Cases of Placenta Accreta and a Literature Review: Use of the B-Lynch Suture and Bilateral Uterine Artery Ligation Procedures. ( 27354921 )
2016
40
Suspected placenta accreta and cesarean hysterectomy: observational cohort utilizing an intraoperative decision strategy. ( 26802252 )
2016
41
Downregulation of miR-29a/b/c in placenta accreta inhibits apoptosis of implantation site intermediate trophoblast cells by targeting MCL1. ( 27871464 )
2016
42
Placenta accreta and anesthesia: A multidisciplinary approach. ( 27375391 )
2016
43
EP14.03: Ultrasound diagnosis and evaluation of the number of prior Caesarean deliveries as risk factor for placenta accreta in placenta previa cases. ( 27646844 )
2016
44
Comment on "Retained Placenta Accreta Mimicking Choriocarcinoma". ( 26933514 )
2016
45
The recurrence risk of placenta accreta following uterine conserving management. ( 26836817 )
2016
46
Another look at ultrasound and magnetic resonance imaging for diagnosis of placenta accreta. ( 27806657 )
2016
47
Correlation of probability scores of placenta accreta on magnetic resonance imaging with hemorrhagic morbidity. ( 27687389 )
2016
48
Direct puncture embolization of the internal iliac artery during cesarean delivery for pernicious placenta previa coexisting with placenta accreta. ( 27634053 )
2016
49
Exposure to air pollutants during the early weeks of pregnancy, and placenta praevia and placenta accreta in the western part of Japan. ( 27164555 )
2016
50
Caesarean hysterectomy for placenta accreta: paracervix should be divided sequentially, not en masse. ( 27129744 )
2016

Variations for Placenta Accreta

Expression for Placenta Accreta

Search GEO for disease gene expression data for Placenta Accreta.

Pathways for Placenta Accreta

Pathways related to Placenta Accreta according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 ANGPT1 ANGPT2 FLT1 KDR PGF TEK
2
Show member pathways
13.1 ANGPT1 ANGPT2 FLT1 KDR PGF TEK
3
Show member pathways
13.03 ANGPT1 ANGPT2 SERPINB2 SERPINE1 TEK
4
Show member pathways
13 ANGPT1 ANGPT2 FLT1 KDR PGF TEK
5 12.33 ANGPT1 ANGPT2 FLT1 KDR PGF TEK
6
Show member pathways
12.27 ANGPT1 ANGPT2 FLT1 KDR PGF TEK
7
Show member pathways
12.12 FLT1 KDR PGF
8
Show member pathways
11.98 FLT1 KDR TEK
9
Show member pathways
11.98 ANGPT1 ANGPT2 TEK
10 11.82 ANGPT2 FLT1 KDR TEK
11
Show member pathways
11.65 FLT1 KDR PGF
12 11.63 ANGPT1 FLT1 TEK
13 11.5 ANGPT2 FLT1 KDR TEK
14 11.35 ANGPT1 ANGPT2 FLT1 SERPINE1 TEK
15 11.18 ANGPT1 ANGPT2 SERPINE1
16 11.15 ANGPT1 TEK
17 11.11 FLT1 KDR SERPINE1
18 10.97 ANGPT2 SERPINE1
19 10.64 SERPINB2 SERPINE1
20 10.3 ANGPT1 FLT1 KDR TEK

GO Terms for Placenta Accreta

Cellular components related to Placenta Accreta according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ANGPT1 ANGPT2 FLT1 PGF SERPINB2 SERPINE1
2 membrane raft GO:0045121 9.33 ANGPT1 KDR TEK
3 extracellular region GO:0005576 9.28 ANGPT1 ANGPT2 CGB3 FLT1 KDR PGF

Biological processes related to Placenta Accreta according to GeneCards Suite gene sharing:

(show all 27)
id Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.93 ANGPT1 ANGPT2 FLT1 KDR PGF
2 cell differentiation GO:0030154 9.92 ANGPT1 ANGPT2 FLT1 KDR PGF
3 negative regulation of apoptotic process GO:0043066 9.85 ANGPT1 KDR SERPINB2 TEK
4 cell-cell signaling GO:0007267 9.81 CGB3 PGF TEK
5 leukocyte migration GO:0050900 9.8 ANGPT1 ANGPT2 TEK
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.78 ANGPT1 KDR TEK
7 protein autophosphorylation GO:0046777 9.77 FLT1 KDR TEK
8 response to hypoxia GO:0001666 9.75 ANGPT2 PGF TEK
9 peptidyl-tyrosine phosphorylation GO:0018108 9.74 FLT1 KDR TEK
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.71 ANGPT1 FLT1 KDR TEK
11 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.67 FLT1 KDR PGF
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.67 ANGPT1 FLT1 KDR TEK
13 positive regulation of endothelial cell proliferation GO:0001938 9.65 KDR PGF TEK
14 animal organ regeneration GO:0031100 9.63 ANGPT2 PGF
15 positive regulation of endothelial cell migration GO:0010595 9.63 ANGPT1 KDR TEK
16 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.62 FLT1 TEK
17 blood vessel morphogenesis GO:0048514 9.61 ANGPT2 FLT1
18 sprouting angiogenesis GO:0002040 9.61 ANGPT1 PGF TEK
19 positive regulation of focal adhesion assembly GO:0051894 9.6 KDR TEK
20 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.58 FLT1 KDR
21 fibrinolysis GO:0042730 9.56 SERPINB2 SERPINE1
22 negative regulation of endothelial cell apoptotic process GO:2000352 9.56 ANGPT1 KDR SERPINE1 TEK
23 vascular endothelial growth factor signaling pathway GO:0038084 9.51 FLT1 KDR
24 glomerulus vasculature development GO:0072012 9.5 ANGPT1 ANGPT2 TEK
25 positive regulation of angiogenesis GO:0045766 9.43 ANGPT2 FLT1 KDR PGF SERPINE1 TEK
26 Tie signaling pathway GO:0048014 9.33 ANGPT1 ANGPT2 TEK
27 angiogenesis GO:0001525 9.17 ANGPT1 ANGPT2 FLT1 KDR PGF SERPINE1

Molecular functions related to Placenta Accreta according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.43 FLT1 KDR TEK
2 receptor tyrosine kinase binding GO:0030971 9.32 ANGPT1 ANGPT2
3 vascular endothelial growth factor-activated receptor activity GO:0005021 9.16 FLT1 KDR
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 FLT1 KDR TEK
5 growth factor binding GO:0019838 8.8 FLT1 KDR TEK

Sources for Placenta Accreta

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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