MCID: PLC008
MIFTS: 48

Placenta Disease

Categories: Rare diseases, Fetal diseases

Aliases & Classifications for Placenta Disease

Summaries for Placenta Disease

Disease Ontology : 12 A uterine disease that is located in the placenta.

MalaCards based summary : Placenta Disease, also known as pregnancy complications, is related to placental insufficiency and antiphospholipid syndrome, and has symptoms including intrapartum fever, maternal fever and late pregnancy bleeding. An important gene associated with Placenta Disease is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and Glucocorticoid receptor regulatory network. The drugs Ethanol and Heparin have been mentioned in the context of this disorder. Affiliated tissues include the placenta, placenta and cervix, and related phenotypes are Increased shRNA abundance and homeostasis/metabolism

Wikipedia : 72 A placental disease is any disease, disorder, or pathology of the placenta. The article also covers... more...

Related Diseases for Placenta Disease

Diseases related to Placenta Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 placental insufficiency 31.8 AFP F3 PGF
2 antiphospholipid syndrome 31.8 APOH F3 F5 MTHFR SERPINC1
3 placenta praevia 31.6 EPHA1 HADHA SERPINH1
4 placental abruption 31.5 APOH F5 MTHFR PGF SERPINC1
5 hellp syndrome 31.1 APOH F3 F5 HADHA IL6 MTHFR
6 chorioamnionitis 30.9 CXCL8 IL6 OXT
7 eclampsia 29.2 F5 MTHFR OXT PAPPA PGF SERPINC1
8 pre-eclampsia 28.1 AFP APOH F3 F5 IL6 MTHFR
9 diethylstilbestrol syndrome 10.9
10 oligohydramnios 10.8
11 placenta accreta 10.8
12 polyhydramnios 10.8
13 inferior vena cava interruption 10.6 F5 MTHFR
14 may-thurner syndrome 10.6 APOH F5
15 acanthamoeba keratitis 10.6 APOH F5
16 amaurosis fugax 10.6 F5 MTHFR
17 mixed germ cell tumor 10.6 AFP CGB3
18 osteoporotic fracture 10.5 IL6 MTHFR
19 livedoid vasculopathy 10.5 APOH F5 MTHFR
20 acquired hemophilia a 10.5 F3 F5
21 pregnancy loss, recurrent 1 10.5 APOH F5 MTHFR
22 tuberculous epididymitis 10.5 AFP CGB3
23 protein c deficiency 10.5 F5 MTHFR SERPINC1
24 nonarteritic anterior ischemic optic neuropathy 10.5 F5 MTHFR SERPINC1
25 intracranial sinus thrombosis 10.5 F3 SERPINC1
26 prothrombin deficiency, congenital 10.5 APOH F5 SERPINC1
27 ischemic colitis 10.5 APOH F5 SERPINC1
28 blood protein disease 10.5 MTHFR SERPINC1
29 intestinal impaction 10.5 F3 SERPINC1
30 sneddon syndrome 10.5 APOH F5 SERPINC1
31 thrombasthenia 10.5 F3 F5 MTHFR
32 fournier gangrene 10.5 F3 SERPINC1
33 heparin-induced thrombocytopenia 10.4 F3 SERPINC1
34 homocysteinemia 10.4 F5 MTHFR SERPINC1
35 cerebral sinovenous thrombosis 10.4 APOH F3 F5
36 marantic endocarditis 10.4 F3 MTHFR SERPINC1
37 varicose veins 10.4 F5 MTHFR SERPINC1
38 acquired hemophilia 10.4 F3 F5
39 sagittal sinus thrombosis 10.4 F3 F5 SERPINC1
40 homocystinuria 10.4 F5 MTHFR SERPINC1
41 sticky platelet syndrome 10.4 F5 SERPINC1
42 hepatitis a 10.4 AFP F3 SERPINC1
43 factor x deficiency 10.4 F3 F5 SERPINC1
44 encephalomalacia 10.4 IL6 MTHFR SERPINH1
45 disseminated intravascular coagulation 10.4 F3 F5 SERPINC1
46 cerebral palsy 10.4 F5 IL6 MTHFR
47 recurrent corneal erosion 10.4 CXCL8 IL6
48 intermittent claudication 10.4 APOH IL6 SERPINC1
49 bagassosis 10.4 CXCL8 IL6
50 angina pectoris 10.4 F3 IL6 SERPINC1

Graphical network of the top 20 diseases related to Placenta Disease:



Diseases related to Placenta Disease

Symptoms & Phenotypes for Placenta Disease

UMLS symptoms related to Placenta Disease:


intrapartum fever, maternal fever, late pregnancy bleeding, morning sickness, hyperemesis gravidarum

GenomeRNAi Phenotypes related to Placenta Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 9.02 AFP CGB3 F5 MTHFR SERPINH1

MGI Mouse Phenotypes related to Placenta Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.47 AFP APOH EPHA1 F3 F5 HADHA

Drugs & Therapeutics for Placenta Disease

Drugs for Placenta Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 869)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 64-17-5 702
2
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 9005-49-6 46507594 772
3
Nitric Oxide Approved Phase 4,Phase 2,Phase 3,Not Applicable 10102-43-9 145068
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
5
Glyburide Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 10238-21-8 3488
6
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6 32051 23994
7
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-83-0 5994
8
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-78-2 2244
9
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-28-2 5757
10
Methotrexate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
11
Iron Approved Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6 23925
12
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 53-86-1 3715
13
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 103-90-2 1983
14
Ibuprofen Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 15687-27-1 3672
15
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 657-24-9 4091 14219
16
Nifedipine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 21829-25-4 4485
17
Methyldopa Approved Phase 4,Phase 2,Phase 1,Not Applicable 555-30-6 38853
18
Isosorbide Dinitrate Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 87-33-2 6883
19
Amiodarone Approved, Investigational Phase 4,Phase 3,Not Applicable 1951-25-3 2157
20
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2 51-45-6, 75614-87-8 774
21
Hydrocortisone Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 50-23-7 657311 5754
22
Copper Approved, Investigational Phase 4,Phase 3 7440-50-8 27099
23
Misoprostol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 59122-46-2 5282381
24
Betamethasone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 378-44-9 9782
25
Phenylephrine Approved Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1 59-42-7 6041
26
Oxymetazoline Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1 1491-59-4 4636
27
Ritodrine Approved, Investigational Phase 4,Not Applicable 26652-09-5 33572
28
Ephedrine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 299-42-3 9294
29
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
30
Calcium Carbonate Approved, Investigational Phase 4,Not Applicable 471-34-1
31
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-56-6 53477758 439302
32
Tinzaparin Approved Phase 4,Phase 3,Early Phase 1 9041-08-1, 9005-49-6 25244225
33
Remifentanil Approved Phase 4,Phase 3,Phase 2,Phase 1 132875-61-7 60815
34
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 38396-39-3, 2180-92-9 2474
35
Citalopram Approved Phase 4,Early Phase 1,Not Applicable 59729-33-8 2771
36
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
37
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
38
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 1197-18-8 5526
39
Cetrorelix Approved, Investigational Phase 4,Phase 2,Phase 3 120287-85-6 25074887 16129715
40
Pyrimethamine Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 58-14-0 4993
41
Sulfadoxine Approved, Investigational Phase 4,Phase 3,Not Applicable 2447-57-6 17134
42
Ampicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 69-53-4 6249
43
Clindamycin Approved, Vet_approved Phase 4,Not Applicable 18323-44-9 29029
44
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
45
Ranolazine Approved, Investigational Phase 4,Phase 2 95635-55-5, 142387-99-3 56959
46
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 90-82-4 7028
47
Ergonovine Approved Phase 4,Phase 3,Not Applicable 60-79-7 443884
48
Menthol Approved Phase 4,Phase 3,Phase 1,Not Applicable 2216-51-5 16666
49
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 437-38-7 3345
50
Carbetocin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 37025-55-1 16681432 71715

Interventional clinical trials:

(show top 50) (show all 3161)

# Name Status NCT ID Phase Drugs
1 Evaluation of SP Resistance and Effectiveness of IPTp in Nigeria Unknown status NCT01636895 Phase 4 Efficacy of suphladoxine/pyrimethamine as IPTp;Efficacy of suphladoxine/pyrimethamine as IPTp
2 Remifentanil for General Anesthesia in Preeclamptics Unknown status NCT00567957 Phase 4 Remifentanil;Saline
3 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
4 Aspirin, Heparin and Miscarriage Unknown status NCT01917799 Phase 4 Aspirin;Heparin
5 Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia Unknown status NCT01718340 Phase 4 Metformin
6 Intralipid Therapy for Recurrent Implantation Failure and Recurrent Miscarriages: Is it a Hope or Myth?A Randomized Clinical Trial Unknown status NCT01679561 Phase 4 intralipid
7 Role of Sildenafil Citrate in Patients With Unexplained Recurrent Miscarriages Unknown status NCT01419392 Phase 4 Sildenafil citrate;matching placebo
8 Treatment of Late Abortion: Evacuatio Uteri or Conservative Treatment Unknown status NCT00256009 Phase 4 Cytotec
9 Evaluation of Therapeutic Strategies for Treatment of Ectopic Pregnancies (EP) and Evaluation of Subsequent Fertility Unknown status NCT00137982 Phase 4
10 Nifedipine Pharmacokinetics and Pharmacodynamics When Used as a Tocolytic in Acute Threatened Preterm Labour Unknown status NCT02068404 Phase 4 Nifedipine
11 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4 methildopa;placebo
12 Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia Unknown status NCT00117546 Phase 4 alpha methyldopa
13 The Value of Oral Micronized Progesterone in the Prevention of Spontaneous Preterm Birth Unknown status NCT02571296 Phase 4 micronized progesterone;Placebo
14 Low Dose Calcium to Prevent Preeclampsia Unknown status NCT02338687 Phase 4
15 Effects of Early Short-term Intravenous Iron Supplements Combinded EPO in Preterm Infants Unknown status NCT02060851 Phase 4 Iron sucrose;EPO
16 Hepatic Function and Bile Acid in Preterm Infants Receiving Parenteral Lipids Emulsion Unknown status NCT01786759 Phase 4 ClinOleic;Intralipid
17 Effects of Parenteral Nutrition With Different Lipid Emulsions in Preterm Infants Unknown status NCT01683162 Phase 4 ClinOleic;Lipofundin;Intralipid
18 The Impact of Bryophyllum on Preterm Delivery Unknown status NCT00163579 Phase 4 Bryophyllum
19 Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial Unknown status NCT02590016 Phase 4 Insulin, Aspart
20 Prevention of Diabetes Mellitus Development in Women Who Had Already Experienced A Gestational Diabetes Unknown status NCT00265746 Phase 4 Metformin
21 Oral Antidiabetic Agents in Pregnancy Unknown status NCT02091336 Phase 4 Metformin;Glyburide
22 Efficacy of Myo-inositol in Preventing Gestational Diabetes in High-risk Pregnant Women Unknown status NCT01511835 Phase 4 Folic Acid
23 PCC and Fibrinogen Compared With FFP in PPH Unknown status NCT01910675 Phase 4 PCC;FFP
24 Oxytocin in Cesarean Delivery Unknown status NCT01236482 Phase 4 Oxytocin versus oxytocin-ergometrine
25 Assessment of Implantation Potential of Embryos by Time-lapse Technology Unknown status NCT01760278 Phase 4 recombinant Follicle Stimulating Hormone (rFSH)
26 Can Resveratrol Improve Insulin Sensitivity and Preserve Beta Cell Function Following Gestational Diabetes? Unknown status NCT01997762 Phase 4
27 BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success Unknown status NCT01860690 Phase 4 Methotrexate
28 Oral Contraceptive Ethinyl Estradiol Dose Effect on Postpartum Depression and Sexual Functioning Scales Unknown status NCT02210702 Phase 4 Ethinyl Estradiol 35mcg/Norethindrone 1mg;Ethinyl Estradiol 20mcg/Norethindrone 1mg
29 ED90 Determination of Carbetocin for the Prevention of Uterine Atony in Women Undergoing an Elective Cesarean Delivery Unknown status NCT01579201 Phase 4 Carbetocin
30 Laparascopy Versus Laparatomy in the Management of Ruptured Ectopic Pregnancy Unknown status NCT01932957 Phase 4
31 To Evaluate the Efficacy and Safety of Wenxin Keli in Treating Atrial Premature Beats Unknown status NCT02319603 Phase 4 Low dose WenXin keli;High dose WenXin keli
32 Diphtheria, Tetanus, Poliomyelitis -Pertussis-Hib Immunisation in Preterm-born Neonates Unknown status NCT02179996 Phase 4
33 Study to Reduce Symptoms of Premature Beats With Ranolazine Unknown status NCT01996618 Phase 4 Ranolazine
34 Effects of ADSC Therapy in Women With POF Unknown status NCT01853501 Phase 4
35 Shensongyangxin Capsule in the Treatment of Sinus Bradycardia With Premature Ventricular Contractions Unknown status NCT01750775 Phase 4 Shensong Yangxin capsule;placebo Capsule
36 Shensong Yangxin Capsule in the Treatment of Heart Failure Complicated With Ventricular Premature Beat Unknown status NCT01612260 Phase 4 Shensong Yangxin capsule;placebo Capsule
37 Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in Prematurity Unknown status NCT00634972 Phase 4 ACULAR;REFRESH TEARS;placebo
38 Postpartum Oxygen Inhalation for the Treatment of Postpartum Haemorrhage Unknown status NCT01180192 Phase 4 oxygen
39 Management of Third-stage of Labor After Second Trimester Medical Pregnancy Termination Completed NCT02969447 Phase 4 Administration of 10 units of intra venous oxytocin after fetal expulsion
40 Intravenous Nitroglycerin for Retained Placenta Extraction: a Multicenter Study Completed NCT00707928 Phase 4 nitroglycerine
41 Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia Completed NCT00270530 Phase 4 Sulfadoxine-pyrimethamine (Fansidar)
42 Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid;Acetylsalicylic Acid
43 Expectant Versus Immediate Medical Management for the Evacuation of the no Evolutionary Pregnancies Before 13 GW Completed NCT00190294 Phase 4 MIFEPRISTONE 200 mg and misoprostol 400 µg
44 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
45 Use of G-CSF for the Treatment of Unexplained Recurrent Miscarriage Completed NCT00772122 Phase 4 G-CSF;saline solution
46 Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies Completed NCT01221844 Phase 4 FerroGrad by Abbott
47 Transdermal Nitroglycerin and Nifedipine in Preterm Labor Completed NCT02583633 Phase 4 Transdermal nitroglycerin;nifedipine
48 Efficacy, Safety and Tolerability of Telbivudine in HBeAg Positive Chronic Hepatitis B Pregnant Women With Elevated Alanine Aminotransferase Levels Completed NCT01337791 Phase 4 Telbivudine treatment
49 Medical Nutrition Therapy Plus Transgestational Metformin For Preventing Gestational Diabetes In High Risk Mexican Women Completed NCT01675310 Phase 4 medical nutrition therapy + metformin
50 Role of Antioxidants in Unexplained Oligohydramnios,A Randomized Trial Completed NCT01990690 Phase 4 anti oxidant omega 3

Search NIH Clinical Center for Placenta Disease

Cochrane evidence based reviews: pregnancy complications

Genetic Tests for Placenta Disease

Anatomical Context for Placenta Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Placenta Disease:

18
The Placenta

MalaCards organs/tissues related to Placenta Disease:

38
Placenta, Cervix, T Cells, Testes, Brain, Uterus, Skin

Publications for Placenta Disease

Articles related to Placenta Disease:

# Title Authors Year
1
Ex Vivo Dual Perfusion of the Human Placenta: Disease Simulation, Therapeutic Pharmacokinetics and Analysis of Off-Target Effects. ( 29197003 )
2018
2
Iliac artery balloon catheter use in abnormally invasive placenta disease management - a reply. ( 29047135 )
2017

Variations for Placenta Disease

Expression for Placenta Disease

Search GEO for disease gene expression data for Placenta Disease.

Pathways for Placenta Disease

Pathways related to Placenta Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 CXCL8 F3 IL6
2 11.05 AFP CXCL8 IL6
3 10.49 CXCL8 IL6 TLR9

GO Terms for Placenta Disease

Cellular components related to Placenta Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 AFP APOH CXCL8 F3 F5 IL6
2 endoplasmic reticulum lumen GO:0005788 9.55 AFP F5 IL6 SERPINC1 SERPINH1
3 extracellular region GO:0005576 9.5 AFP APOH CGB3 CSH1 CSH2 CXCL8

Biological processes related to Placenta Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.61 OXT PAPPA PGF
2 response to glucocorticoid GO:0051384 9.5 IL6 OXT PAPPA
3 positive regulation of angiogenesis GO:0045766 9.46 CXCL8 EPHA1 F3 PGF
4 hemostasis GO:0007599 9.43 F3 F5 SERPINC1
5 induction of positive chemotaxis GO:0050930 9.4 CXCL8 PGF
6 response to molecule of bacterial origin GO:0002237 9.37 CXCL8 TLR9
7 cellular protein metabolic process GO:0044267 9.35 AFP F5 IL6 PAPPA SERPINC1
8 regulation of receptor activity GO:0010469 9.17 CGB3 CSH1 CSH2 CXCL8 IL6 OXT

Molecular functions related to Placenta Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 CGB3 CSH1 CSH2 OXT

Sources for Placenta Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
44