MCID: PLC007
MIFTS: 51

Placental Abruption malady

Fetal diseases category
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Summaries for Placental Abruption

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Disease Ontology:8 A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

MalaCards based summary: Placental Abruption, also known as abruptio placentae, is related to eclampsia and hypertension. An important gene associated with Placental Abruption is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Cell surface interactions at the vascular wall. The compounds perindopril and 8-isoprostane have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and heart, and related mouse phenotypes are hematopoietic system and cardiovascular system.

Wikipedia:65 Placental abruption (also known as abruptio placentae) is a complication of pregnancy, wherein the... more...

Aliases & Classifications for Placental Abruption

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Placental Abruption, Aliases & Descriptions:

Name: Placental Abruption 8 9 46 10 62
Abruptio Placentae 8 46 44 62
 
Abruptio Placentae, Susceptibility to 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


External Ids:

Disease Ontology8 DOID:9667
ICD9CM27 640.0
MeSH34 D000033

Related Diseases for Placental Abruption

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Graphical network of the top 20 diseases related to Placental Abruption:



Diseases related to placental abruption

Symptoms for Placental Abruption

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Drugs & Therapeutics for Placental Abruption

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Drug clinical trials:

Search ClinicalTrials for Placental Abruption

Search NIH Clinical Center for Placental Abruption

Genetic Tests for Placental Abruption

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Anatomical Context for Placental Abruption

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MalaCards organs/tissues related to Placental Abruption:

32
Placenta, Uterus, Heart, Testes, Endothelial, Spleen, Brain, Retina

Animal Models for Placental Abruption or affiliated genes

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MGI Mouse Phenotypes related to Placental Abruption:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.4NOS3, PROC, EBAG9, THBD
2MP:00053857.8THBD, PROC, F5, NOS3
3MP:00053707.7NOS3, F5, BHMT, PROC, THBD
4MP:00053787.6THBD, PROC, BHMT, F5, NOS3
5MP:00053767.5THBD, PROC, BHMT, F5, NOS3

Publications for Placental Abruption

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Articles related to Placental Abruption:

(show top 50)    (show all 285)
idTitleAuthorsYear
1
Is there an association between a history of placental abruption and long-term maternal renal complications? (25234099)
2014
2
Predictors of perinatal mortality associated with placenta previa and placental abruption: an experience from a low income country. (25002975)
2014
3
Risk factors of placental abruption. (24174950)
2013
4
Decreasing perinatal mortality in placental abruption. (23072758)
2013
5
Placenta praevia, placental abruption and amphetamine use in pregnancy: a case study. (23266230)
2013
6
The ability of computed tomography to diagnose placental abruption in the trauma patient. (23271100)
2013
7
MR imaging in the evaluation of placental abruption: correlation with sonographic findings. (21330568)
2011
8
Two cases of angular pregnancy complicated by preterm labor and placental abruption at mid-pregnancy. (21450029)
2011
9
Is the perinatal outcome of placental abruption modified by clinical presentation? (21490793)
2011
10
Hysterotomy and evacuation of a deciduate placental hematoma following placental abruption. (20624620)
2010
11
Self-reported smoking habits and serum cotinine levels in women with placental abruption. (21050148)
2010
12
Maternal deaths in Finland: focus on placental abruption. (19707898)
2009
13
Pre-eclampsia, placental abruption and increased risk of atopic sensitization in male adolescent offspring. (19811463)
2009
14
The increase in metallothionein and ectopic decidual immunoreactivity with respect to the progression of labor at term and the lack of analogical changes in placental abruption. (18782281)
2008
15
Low birthweight in relation to placental abruption and maternal thrombophilia status. (18191809)
2008
16
Folic acid and multivitamin supplement use and risk of placental abruption: a population-based registry study. (18187445)
2008
17
Failure of second-trimester measurement of soluble endoglin and other angiogenic factors to predict placental abruption. (17960788)
2007
18
Risk and risk estimation of placental abruption. (16202500)
2006
19
Uterine torsion with placental abruption. (16483985)
2006
20
Placental abruption in term and preterm gestations: evidence for heterogeneity in clinical pathways. (16582113)
2006
21
Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in Finnish women. (16260885)
2005
22
Anti-fetal immune response mechanisms may be involved in the pathogenesis of placental abruption. (14962795)
2004
23
Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption. (15582499)
2004
24
Could placental abruption be an antiphospholipid antibody related disorder? (15144143)
2004
25
Sucessful pregnancy outcome following three severe placental abruptions and intrauterine fetal death in the patient--heterozygous carrier of R506Q mutation of factor V (Leiden)]. (15518286)
2004
26
Interventions for treating placental abruption. (12535464)
2003
27
Placental abruption is associated with decreased maternal plasma levels of soluble HLA-G. (12959223)
2003
28
Clinical utility of sonography in the diagnosis and treatment of placental abruption. (12164566)
2002
29
Thrombin-enhanced matrix metalloproteinase-1 expression: a mechanism linking placental abruption with premature rupture of the membranes. (12380602)
2002
30
Placental abruption. (11997676)
2002
31
The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption. (11354626)
2001
32
Sonolucency of a fresh hematoma in a case of marginal placental abruption. (11451559)
2001
33
Placental abruption and adverse perinatal outcomes. (10553791)
1999
34
Is fetal gender significant in the perinatal outcome of pregnancies complicated by placental abruption? (15512413)
1999
35
Thrombomodulin: a new marker for placental abruption. (9974370)
1999
36
Preterm labor, placental abruption, and premature rupture of membranes in relation to maternal violence or verbal abuse. (10338059)
1999
37
The effect on the likelihood of further pregnancy of placental abruption and the rate of its recurrence. (9800939)
1998
38
Plasma fibrin D-dimer in pregnancies complicated by partial placental abruption. (9323905)
1997
39
Maternal serum alpha-fetoprotein in placental abruption associated with preterm labor. (9127154)
1997
40
Influence of hypertensive disorders and cigarette smoking on placental abruption and uterine bleeding during pregnancy. (9166200)
1997
41
Placental abruption following placement of disposable intrauterine pressure transducer system. (8442792)
1993
42
Conservative management of placental abruption complicated by severe clotting disorders. (1426497)
1992
43
Feto-pelvic disproportion of mimicking placental abruption. (2102210)
1990
44
Pulmonary thromboembolism complicating recurrent placental abruption at 29 weeks' gestation. (2400355)
1990
45
Uteroplacental and umbilical artery blood velocity waveforms in placental abruption assessed by Doppler ultrasound. (2930753)
1989
46
Placental abruption associated with cocaine abuse. (3285653)
1988
47
Expectant management of partial placental abruption in previable pregnancies. A report of two cases. (3316649)
1987
48
Placental abruption and subchorionic hemorrhage in the first half of pregnancy: US appearance and clinical outcome. (3520643)
1986
49
Case report: ruptured spleen, placental abruption and toxemia of pregnancy. Simultaneous complications of pregnancy. (927413)
1977
50
Pathogenesis of hypofibrinogenemia in placental abruption. (13674508)
1959

Variations for Placental Abruption

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Expression for genes affiliated with Placental Abruption

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Expression patterns in normal tissues for genes affiliated with Placental Abruption

Search GEO for disease gene expression data for Placental Abruption.

Pathways for genes affiliated with Placental Abruption

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Compounds for genes affiliated with Placental Abruption

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Compounds related to Placental Abruption according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1perindopril44 50 1111.9NOS3, THBD
28-isoprostane449.9NOS3, THBD
3fluvastatin44 50 28 1112.8THBD, NOS3
4pravastatin44 50 28 24 1113.7NOS3, THBD
5azathioprine44 2 50 1112.7THBD, NOS3
6cystathionine449.6F5, BHMT
7hirugen449.6F5, THBD
8ximelagatran44 1110.6THBD, F5
9ancrod449.6THBD, F5
10heparinoids449.6F5, THBD
11fondaparinux449.5THBD, F5
12bivalirudin44 1110.5THBD, F5
13argatroban44 1110.5F5, THBD
14cacl2449.5F5, THBD
15benzamidine44 1110.5F5, THBD
16desmopressin44 61 28 1112.5THBD, F5
17cardiolipin44 1110.5F5, THBD
18vitamin b12449.5F5, BHMT
19hirudin449.5F5, THBD
20mycophenolate mofetil44 50 1111.5THBD, F5
21dermatan sulfate449.4F5, THBD
22kininogen449.4F5, THBD
23tunicamycin44 6110.4F5, THBD
24pge1449.4F5, THBD
25aprotinin44 1110.4THBD, F5
26polyethylene glycol449.3F5, THBD
27sodium dodecylsulfate449.3NOS3, F5
28vitamin-e449.3F5, THBD
29raloxifene44 50 28 1112.2THBD, F5, NOS3
30atorvastatin44 50 28 24 1113.2NOS3, F5, THBD
31citrate449.1NOS3, F5, THBD
32simvastatin44 50 61 28 24 1114.1NOS3, F5, THBD
33cyclophosphamide44 50 1111.1NOS3, F5, THBD
34prostacyclin449.1NOS3, F5, THBD
35vitamin b6449.1F5, BHMT, THBD
36aspirin44 50 28 2412.1THBD, F5, NOS3
37ascorbic acid44 2410.1THBD, F5, NOS3
38gamma-carboxyglutamic acid449.0F5, PROC, THBD
39warfarin44 50 24 1111.9F5, PROC, THBD
40fibrinogen448.9F5, PROC, THBD
41phospholipid448.9F5, PROC, THBD
42heparin44 28 24 1111.8F5, PROC, THBD
43vegf448.7NOS3, F5, THBD
44glutamate448.7NOS3, F5, THBD
45homocysteine44 249.7NOS3, F5, BHMT, THBD
46folate448.7THBD, BHMT, F5, NOS3
47arginine448.6THBD, F5, NOS3
48estrogen448.6THBD, EBAG9, F5, NOS3
49nitric oxide44 24 1110.4NOS3, F5, THBD
50serine448.1THBD, PROC, BHMT, F5, NOS3

GO Terms for genes affiliated with Placental Abruption

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Cellular components related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.6NOS3, F5, PROC, EBAG9, THBD

Biological processes related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:0105449.4THBD, NOS3
2leukocyte migrationGO:0509009.3PROC, THBD
3negative regulation of blood coagulationGO:0301959.0PROC, THBD
4blood coagulationGO:0075968.1NOS3, F5, PROC, THBD

Molecular functions related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.0F5, PROC

Products for genes affiliated with Placental Abruption

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Sources for Placental Abruption

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet