MCID: PLC007
MIFTS: 53

Placental Abruption malady

Summaries for Placental Abruption

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

MalaCards: Placental Abruption, also known as abruptio placentae, is related to eclampsia and hypertension. An important gene associated with Placental Abruption is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are Common Pathway and Complement and coagulation cascades. The compounds warfarin and glutamate have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and heart, and related mouse phenotypes are integument and embryogenesis.

Wikipedia:63 Placental abruption (also known as abruptio placentae) is a complication of pregnancy, wherein the... more...

Aliases & Classifications for Placental Abruption

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8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

placental abruption 8 9 46 10
abruptio placentae 8 46 44 60
abruptio placentae, susceptibility to 9


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Disease Ontology8 DOID:9667
ICD9CM27 640.0
MeSH34 D000033

Related Diseases for Placental Abruption

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17GeneCards, 18GeneDecks
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Diseases related to Placental Abruption via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia30.8THBD, MTHFR
2hypertension30.7NOS3, PGF, MTHFR, F5
3pre-eclampsia30.7F5, MTHFR, PGF, THBD, NOS3, ENG
4thrombophilia30.6F5, MTHFR, PROC, THBD
5placenta praevia30.5APEH
6disseminated intravascular coagulation30.5THBD, PROC, F5
7deficiency anemia30.2ENG
8obesity30.1NOS3
9hellp syndrome30.1MTHFR, F5
10acute leukemia30.1MTHFR
11severe pre-eclampsia30.1F5, PGF
12thrombocytopenia30.1THBD, F5
13migraine30.1MTHFR
14leukemia30.1MRPL28, MTHFR, PGF, SLC19A1, ENG
15hyperhomocysteinemia30.1F5, MTRR, MTHFR, BHMT, THBD, SLC19A1
16supine hypotensive syndrome10.4
17chorioamnionitis10.3
18vaginitis10.3
19cocaine abuse10.3
20hypothyroidism10.3
21paralytic ileus10.2
22anuria10.2
23iron deficiency anemia10.2
24renal hypertension10.2
25crohn's disease10.1
26chorioangioma10.1
27pseudotumor cerebri10.1
28tuberous sclerosis10.1
29q fever10.1
30placental site trophoblastic tumor10.1
31diabetes insipidus10.1
32listeriosis10.1
33hemolytic-uremic syndrome10.1
34angiomyolipoma10.1
35cervicitis10.1
36drug dependence10.1
37hepatitis10.1
38influenza10.1
39oligohydramnios10.1
40galactosemia10.0F5
41arthritis10.0PGF
42vascular disease10.0THBD
43meningioma10.0PGF
44cerebrovascular disease10.0MTHFR
45cholangiocarcinoma10.0EBAG9
46malaria10.0MRPL28
47hereditary hemorrhagic telangiectasia10.0ENG
48branch retinal artery occlusion10.0F5
49osteosarcoma10.0SLC19A1
50hepatopulmonary syndrome10.0NOS3

Graphical network of the top 20 diseases related to Placental Abruption:



Diseases related to placental abruption

Clinical Features for Placental Abruption

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Drugs & Therapeutics for Placental Abruption

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Placental Abruption

Drug clinical trials:

Search ClinicalTrials for Placental Abruption

Search NIH Clinical Center for Placental Abruption

Search CenterWatch for Placental Abruption

Genetic Tests for Placental Abruption

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Anatomical Context for Placental Abruption

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32MalaCards
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MalaCards organs/tissues related to Placental Abruption:

32
Placenta, Uterus, Heart, Testes, Endothelial, Spleen, Brain, Retina

Animal Models for Placental Abruption or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Placental Abruption:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.8ENG, SLC19A1, PZP
2MP:00053809.7F5, PGF, THBD, SLC19A1, NOS3, ENG
3MP:00053709.7PZP, F5, PROC, BHMT, THBD, SLC19A1
4MP:00053789.2PROC, MTHFR, MTRR, F5, PZP, BHMT
5MP:00053769.1ENG, PZP, F5, MTRR, MT3, MTHFR

Publications for Placental Abruption

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50PubMed
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Articles related to Placental Abruption:

(show top 50)    (show all 271)
idTitleAuthorsYear
1
Decision-to-delivery interval in suspected placental abruption - association with pregnancy outcome. (24299101)
2014
2
Traumatic Abruptio Placenta Scale (TAPS): a proposed grading system of computed tomography evaluation of placental abruption in the trauma patient. (24057218)
2014
3
Subclinical hypothyroidism as a risk factor for placental abruption: evidence from a low-risk primigravid population. (24111733)
2013
4
Social disparity affects the incidence of placental abruption among multiparous but not nulliparous women: a register-based analysis of 1,162,126 singleton births. (24094822)
2013
5
Non-mosaic uniparental trisomy 16 presenting with asplenia syndrome and placental abruption: a case report and literature review. (23395980)
2013
6
Optimal treatment of hypothyroidism associated with live birth in cases of previous recurrent placental abruption and stillbirth. (24055168)
2013
7
Decreasing incidence of placental abruption in Finland during 1980-2005. (22582999)
2012
8
Two cases of angular pregnancy complicated by preterm labor and placental abruption at mid-pregnancy. (21450029)
2011
9
Placental abruption: epidemiology, risk factors and consequences. (21241259)
2011
10
Clinical significance of singleton pregnancies complicated by placental abruption associated with histological chorioamnionitis. (20818138)
2010
11
Maternal deaths in Finland: focus on placental abruption. (19707898)
2009
12
Occurrence of placental abruption in relatives. (19191777)
2009
13
A population-based study of race-specific risk for placental abruption. (18789147)
2008
14
Circulating soluble endoglin and placental abruption. (18702104)
2008
15
Placental abruption is more frequent in women with the angiotensinogen Thr235 mutation. (17116328)
2007
16
Association of caesarean delivery for first birth with placenta praevia and placental abruption in second pregnancy. (17355267)
2007
17
Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption. (17376725)
2007
18
Histologic evidence of inflammation and risk of placental abruption. (17826437)
2007
19
Risk and risk estimation of placental abruption. (16202500)
2006
20
Uterine torsion with placental abruption. (16483985)
2006
21
Previous cesarean delivery and risks of placenta previa and placental abruption. (16582111)
2006
22
Clinical presentation and risk factors of placental abruption. (16752262)
2006
23
Acute abdomen in Crohn's disease mimicking concealed placental abruption in pregnancy. (16483984)
2006
24
MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women. (16867914)
2006
25
Pathologic uterine torsion associated with placental abruption, maternal shock, and intrauterine fetal demise. (15970905)
2005
26
Anti-fetal immune response mechanisms may be involved in the pathogenesis of placental abruption. (14962795)
2004
27
Fetal inherited thrombophilias influence the severity of preeclampsia, IUGR and placental abruption. (15036707)
2004
28
Interventions for treating placental abruption. (12535464)
2003
29
Hysterotomy for maternal life-threatening hemorrhage secondary to placental abruption at 24 weeks gestation. (12918463)
2003
30
Placental abruption. (11997676)
2002
31
Pregnancy following placental abruption. (12410366)
2002
32
Reproductive risk factors, Doppler findings, and outcome of affected births in placental abruption: a population-based analysis. (12541219)
2002
33
Sonolucency of a fresh hematoma in a case of marginal placental abruption. (11451559)
2001
34
Clotting disorders and placental abruption: homocysteine--a new risk factor. (11301173)
2001
35
Infarction of a placental chorioangioma mimicking placental abruption. (15512347)
1999
36
Twin pregnancy in a uterus didelphys, with unilateral placental abruption and onset of labour. (10687777)
1999
37
The effect on the likelihood of further pregnancy of placental abruption and the rate of its recurrence. (9800939)
1998
38
Maternal age modifies the effect of maternal smoking on intrauterine growth retardation but not on late fetal death and placental abruption. (9054235)
1997
39
Hyperhomocysteinemia: a risk factor for placental abruption or infarction. (8735754)
1996
40
The occurrence of placental abruption in Norway 1967-1991. (8607333)
1996
41
Fetal heart rate monitoring casebook. Fetal heart rate monitoring and severe placental abruption. (1919832)
1991
42
Placental abruption following vaginal administration of prostaglandin E2 for induction of labour. (1369540)
1990
43
Panic attack-associated placental abruption: a case report. (2738032)
1989
44
Correlates of placental abruption. (3580316)
1987
45
Umbilical cord damage and placental abruption during amniocentesis. (6730948)
1984
46
Placental protein 5 (PP5) in placental abruption. (7236553)
1981
47
Placenta previa followed by total placental abruption. (7429899)
1980
48
Urinary estriol excretion before severe placental abruption. (5473999)
1970
49
Cystic brain alteration after incomplete placental abruption in monkey. (4978862)
1969
50
Mechanism and prevention of distal tubular necrosis in dogs following experimental placental abruption. (13580796)
1958

Genetic Variations for Placental Abruption

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Expression for genes affiliated with Placental Abruption

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Placental Abruption

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Pathways for genes affiliated with Placental Abruption

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53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Placental Abruption

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Placental Abruption according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.8PROC
2glutamate4410.7MT3, THBD
3hirugen4410.7THBD, F5
4raloxifene44 28 49 1113.7NOS3, F5
5betaine44 2411.6BHMT, MTHFR, MTRR
6gamma-carboxyglutamic acid4410.6THBD, PROC, F5
7tetrahydrofolate4410.6SLC19A1, MTHFR, MTRR
8riboflavin44 11 2412.6BHMT, MTHFR, MTRR
9ancrod4410.6F5, THBD
10b vitamins4410.6MTRR, MTHFR
11ximelagatran44 1111.6F5, THBD
12methylcobalamin44 2411.6MTRR, MTHFR
13heparinoids4410.6THBD, F5
14vitamin b64410.5THBD, BHMT, MTHFR, F5
15fondaparinux4410.5THBD, F5
16cystathionine4410.5BHMT, MTHFR, MTRR, F5
17serine4410.5APEH, TFPI2, BHMT
18matrigel4410.5TFPI2, PGF, NOS3
195-methyltetrahydrofolate44 1111.5F5, MTRR, MTHFR, SLC19A1
20vitamin b124410.5F5, MTRR, MTHFR, BHMT
21heparin44 28 11 2413.5PGF, MTHFR, TFPI2
22creatinine4410.5F5, MT3, THBD
23cyanocobalamin49 11 2412.5MTRR, MTHFR
24cyclophosphamide44 49 1112.5F5, MTHFR, THBD, NOS3
25hydroxocobalamin44 1111.5MTRR, MTHFR
26atorvastatin44 49 28 11 2414.5NOS3, THBD, PGF, F5
27s-adenosylmethionine44 11 2412.5SLC19A1, BHMT, MTHFR, MTRR
2810-formyltetrahydrofolate4410.4MTHFR, SLC19A1
29tunicamycin44 5911.4F5, THBD, SLC19A1
30prostacyclin4410.4F5, PGF, THBD, NOS3
31aspirin44 49 28 2413.4F5, MTHFR, THBD, NOS3
32mercaptopurine49 1111.4MTHFR, SLC19A1
33methotrexate44 49 1112.4NOS3, SLC19A1, MTHFR, MTRR
34p0024410.4TFPI2, F5, MTHFR, ENG
35Drotrecogin alfa1110.4F5, THBD
36methionine4410.4MTRR, MTHFR, BHMT, THBD, SLC19A1
37bivalirudin44 1111.4F5, THBD
38fibrinogen4410.3F5, MTHFR, PROC, EPHA1, THBD
39ascorbic acid44 2411.3F5, MT3, MTHFR, THBD, NOS3, ENG
40pteridine4410.3SLC19A1, NOS3
41homocysteine44 2411.2NOS3, F5, MTRR, MTHFR, BHMT, THBD
42folate4410.2F5, MTRR, MTHFR, BHMT, THBD, SLC19A1
43argatroban44 1111.2THBD, F5
44aspartate4410.2APEH, TFPI2, F5, MTRR, MTHFR, THBD
45vegf4410.2F5, EPHA1, PGF, THBD, NOS3, ENG
46nitric oxide44 11 2412.2F5, MTRR, EPHA1, PGF, THBD, NOS3
47thymidylate4410.2SLC19A1, MTHFR, MTRR
48alanine4410.1APEH, F5, MTRR, MTHFR, THBD, SLC19A1
49cysteine4410.0ENG, APEH, F5, MT3, MTHFR, BHMT
50azathioprine44 49 2 1112.9MTHFR, THBD, NOS3

GO Terms for genes affiliated with Placental Abruption

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16Gene Ontology
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Biological processes related to Placental Abruption according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:01054410.4NOS3, THBD
2folic acid metabolic processGO:04665510.4SLC19A1, MTHFR
3methionine biosynthetic processGO:00908610.4BHMT, MTHFR, MTRR
4negative regulation of blood coagulationGO:03019510.3THBD, PROC
5female pregnancyGO:00756510.2PZP, PGF, THBD
6water-soluble vitamin metabolic processGO:00676710.2MTRR, MTHFR, SLC19A1
7blood coagulationGO:00759610.1TFPI2, F5, PROC, THBD, NOS3
8vitamin metabolic processGO:00676610.1MTRR, MTHFR, SLC19A1
9positive regulation of angiogenesisGO:0457669.8NOS3, PGF, EPHA1

Molecular functions related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1FMN bindingGO:01018110.3NOS3, MTRR
2NADPH-hemoprotein reductase activityGO:00395810.2NOS3, MTRR
3cadmium ion bindingGO:04687010.0NOS3, MT3

Products for genes affiliated with Placental Abruption

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Sources for Placental Abruption

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet