MCID: PLC007
MIFTS: 53

Placental Abruption malady

Summaries for Placental Abruption

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

MalaCards: Placental Abruption, also known as abruptio placentae, is related to eclampsia and hypertension. An important gene associated with Placental Abruption is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are Common Pathway and Complement and coagulation cascades. The compounds warfarin and glutamate have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and heart, and related mouse phenotypes are integument and embryogenesis.

Wikipedia:63 Placental abruption (also known as abruptio placentae) is a complication of pregnancy, wherein the... more...

Aliases & Classifications for Placental Abruption

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8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

placental abruption 8 9 46 10
abruptio placentae 8 46 44 60
abruptio placentae, susceptibility to 9


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Disease Ontology8 DOID:9667
ICD9CM27 640.0
MeSH34 D000033

Related Diseases for Placental Abruption

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17GeneCards, 18GeneDecks
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Diseases related to Placental Abruption via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia30.8THBD, MTHFR
2hypertension30.7NOS3, PGF, MTHFR, F5
3pre-eclampsia30.7F5, MTHFR, PGF, THBD, NOS3, ENG
4thrombophilia30.6F5, MTHFR, PROC, THBD
5placenta praevia30.5APEH
6disseminated intravascular coagulation30.5THBD, PROC, F5
7deficiency anemia30.2ENG
8obesity30.1NOS3
9hellp syndrome30.1MTHFR, F5
10acute leukemia30.1MTHFR
11severe pre-eclampsia30.1F5, PGF
12thrombocytopenia30.1THBD, F5
13migraine30.1MTHFR
14leukemia30.1MRPL28, MTHFR, PGF, SLC19A1, ENG
15hyperhomocysteinemia30.1F5, MTRR, MTHFR, BHMT, THBD, SLC19A1
16supine hypotensive syndrome10.4
17chorioamnionitis10.3
18vaginitis10.3
19cocaine abuse10.3
20hypothyroidism10.3
21paralytic ileus10.2
22anuria10.2
23iron deficiency anemia10.2
24renal hypertension10.2
25crohn's disease10.1
26chorioangioma10.1
27pseudotumor cerebri10.1
28tuberous sclerosis10.1
29q fever10.1
30placental site trophoblastic tumor10.1
31diabetes insipidus10.1
32listeriosis10.1
33hemolytic-uremic syndrome10.1
34angiomyolipoma10.1
35cervicitis10.1
36drug dependence10.1
37hepatitis10.1
38influenza10.1
39oligohydramnios10.1
40galactosemia10.0F5
41arthritis10.0PGF
42vascular disease10.0THBD
43meningioma10.0PGF
44cerebrovascular disease10.0MTHFR
45cholangiocarcinoma10.0EBAG9
46malaria10.0MRPL28
47hereditary hemorrhagic telangiectasia10.0ENG
48branch retinal artery occlusion10.0F5
49osteosarcoma10.0SLC19A1
50hepatopulmonary syndrome10.0NOS3

Graphical network of the top 20 diseases related to Placental Abruption:



Diseases related to placental abruption

Clinical Features for Placental Abruption

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Drugs & Therapeutics for Placental Abruption

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Placental Abruption

Drug clinical trials:

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Search NIH Clinical Center for Placental Abruption

Search CenterWatch for Placental Abruption

Genetic Tests for Placental Abruption

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Anatomical Context for Placental Abruption

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32MalaCards
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MalaCards organs/tissues related to Placental Abruption:

32
Placenta, Uterus, Heart, Testes, Endothelial, Spleen, Brain, Retina

Animal Models for Placental Abruption or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Placental Abruption:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.8ENG, SLC19A1, PZP
2MP:00053809.7F5, PGF, THBD, SLC19A1, NOS3, ENG
3MP:00053709.7PZP, F5, PROC, BHMT, THBD, SLC19A1
4MP:00053789.2PROC, MTHFR, MTRR, F5, PZP, BHMT
5MP:00053769.1ENG, PZP, F5, MTRR, MT3, MTHFR

Publications for Placental Abruption

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50PubMed
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Articles related to Placental Abruption:

(show top 50)    (show all 271)
idTitleAuthorsYear
1
Decreasing perinatal mortality in placental abruption. (23072758)
2013
2
Loss of a close family member the year before or during pregnancy and the risk of placental abruption: a cohort study from Denmark and Sweden. (24067196)
2013
3
Early-onset severe growth restriction and placental abruption associated with Breus mole. (21315344)
2011
4
Thyroperoxidase and thyroglobulin antibodies in early pregnancy and placental abruption. (21252741)
2011
5
Placental abruption: critical analysis of risk factors and perinatal outcomes. (20828239)
2011
6
Clinical significance of singleton pregnancies complicated by placental abruption occurred at preterm compared with those occurred at term. (20414664)
2011
7
Misquoting Page's classification for placental abruption in Japan? (21392165)
2011
8
Hysterotomy and evacuation of a deciduate placental hematoma following placental abruption. (20624620)
2010
9
Self-reported smoking habits and serum cotinine levels in women with placental abruption. (21050148)
2010
10
Risk of placental abruption in relation to migraines and headaches. (20977769)
2010
11
Effects of intimate partner violence on pregnancy trauma and placental abruption. (20575710)
2010
12
Male fetal sex is associated with earlier onset of placental abruption. (20199362)
2010
13
Can pseudotumor cerebri predispose to placental abruption? (20375936)
2010
14
Pre-eclampsia, placental abruption and increased risk of atopic sensitization in male adolescent offspring. (19811463)
2009
15
Does placenta position modify the risk of placental abruption in car crashes? (19675977)
2009
16
Bilateral acute functional disturbance in the retina following placental abruption. (20020254)
2009
17
Fetal heart rate pattern reflecting the severity of placental abruption. (17896112)
2008
18
Frequency of selected thrombophilias in women with placental abruption. (17627684)
2007
19
Chronic hypertension and risk of placental abruption: is the association modified by ischemic placental disease? (17826417)
2007
20
Influence of maternal smoking on placental abruption in successive pregnancies: a population-based prospective cohort study in Sweden. (17548787)
2007
21
Predicting placental abruption and previa in women with a previous cesarean delivery. (17514600)
2007
22
Pregnancy outcomes in placental abruption. (17128829)
2006
23
Influence of placental position on outcome in patients with placental abruption. (17220588)
2006
24
Acute and chronic respiratory diseases in pregnancy: associations with placental abruption. (17000252)
2006
25
Cardiac failure caused by severe pre-eclampsia with placental abruption, and its treatment with anti-hypertensive drugs. (14641706)
2003
26
Factor V Leiden in pregnancies complicated by placental abruption. (12742330)
2003
27
Thrombin-enhanced matrix metalloproteinase-1 expression: a mechanism linking placental abruption with premature rupture of the membranes. (12380602)
2002
28
The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption. (11354626)
2001
29
Placental abruption among singleton and twin births in the United States: risk factor profiles. (11296149)
2001
30
Quantitative digital analysis of regional placental perfusion using power Doppler in placental abruption. (11309168)
2001
31
First-birth cesarean and placental abruption or previa at second birth(1). (11339931)
2001
32
Co-existence of spontaneous rupture of uterine artery and placental abruption. (15512523)
2000
33
Dysfibrinogenemia and placental abruption. (10808030)
2000
34
Thrombomodulin: a new marker for placental abruption. (9974370)
1999
35
Placental abruption and intrauterine death following an ant sting. (9849718)
1998
36
Placental abruption and its association with hypertension and prolonged rupture of membranes: a methodologic review and meta-analysis. (8692522)
1996
37
Maternal cigarette smoking as a risk factor for placental abruption, placenta previa, and uterine bleeding in pregnancy. (8890666)
1996
38
The Kleihauer-Betke test. Clinical utility, indication, and correlation in patients with placental abruption and cocaine use. (7487403)
1995
39
Postpartum hemolytic uremic syndrome following placental abruption. (8405636)
1993
40
Expectant management after sonographic diagnosis of placental abruption. (1575837)
1992
41
Relationship between antepartum cocaine abuse, abnormal umbilical artery Doppler velocimetry, and placental abruption. (2067775)
1991
42
Uteroplacental and umbilical artery blood velocity waveforms in placental abruption assessed by Doppler ultrasound. (2930753)
1989
43
The management of severe disseminated intravascular coagulopathy complicating placental abruption in the second trimester of pregnancy. (3382618)
1988
44
Uteroplacental and umbilical artery blood velocity waveforms in placental abruption assessed by Doppler ultrasound. Case report. (3046652)
1988
45
Sonographic spectrum of placental abruption. (3538831)
1987
46
Placental abruption and placental hemorrhage: correlation of sonographic findings with fetal outcome. (3299486)
1987
47
Fetal outcome after intraamniotic hemorrhage with placental abruption. A report of three cases. (3543345)
1986
48
Congenital hypofibrinogenemia and recurrent placental abruption. (6828283)
1983
49
Visualization of placental abruption by blood pool scanning. (4417687)
1974
50
Pathogenesis of hypofibrinogenemia in placental abruption. (13674508)
1959

Genetic Variations for Placental Abruption

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Expression for genes affiliated with Placental Abruption

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Placental Abruption

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Pathways for genes affiliated with Placental Abruption

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53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Placental Abruption

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Placental Abruption according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.8PROC
2glutamate4410.7MT3, THBD
3hirugen4410.7THBD, F5
4raloxifene44 28 49 1113.7NOS3, F5
5betaine44 2411.6BHMT, MTHFR, MTRR
6gamma-carboxyglutamic acid4410.6THBD, PROC, F5
7tetrahydrofolate4410.6SLC19A1, MTHFR, MTRR
8riboflavin44 11 2412.6BHMT, MTHFR, MTRR
9ancrod4410.6F5, THBD
10b vitamins4410.6MTRR, MTHFR
11ximelagatran44 1111.6F5, THBD
12methylcobalamin44 2411.6MTRR, MTHFR
13heparinoids4410.6THBD, F5
14vitamin b64410.5THBD, BHMT, MTHFR, F5
15fondaparinux4410.5THBD, F5
16cystathionine4410.5BHMT, MTHFR, MTRR, F5
17serine4410.5APEH, TFPI2, BHMT
18matrigel4410.5TFPI2, PGF, NOS3
195-methyltetrahydrofolate44 1111.5F5, MTRR, MTHFR, SLC19A1
20vitamin b124410.5F5, MTRR, MTHFR, BHMT
21heparin44 28 11 2413.5PGF, MTHFR, TFPI2
22creatinine4410.5F5, MT3, THBD
23cyanocobalamin49 11 2412.5MTRR, MTHFR
24cyclophosphamide44 49 1112.5F5, MTHFR, THBD, NOS3
25hydroxocobalamin44 1111.5MTRR, MTHFR
26atorvastatin44 49 28 11 2414.5NOS3, THBD, PGF, F5
27s-adenosylmethionine44 11 2412.5SLC19A1, BHMT, MTHFR, MTRR
2810-formyltetrahydrofolate4410.4MTHFR, SLC19A1
29tunicamycin44 5911.4F5, THBD, SLC19A1
30prostacyclin4410.4F5, PGF, THBD, NOS3
31aspirin44 49 28 2413.4F5, MTHFR, THBD, NOS3
32mercaptopurine49 1111.4MTHFR, SLC19A1
33methotrexate44 49 1112.4NOS3, SLC19A1, MTHFR, MTRR
34p0024410.4TFPI2, F5, MTHFR, ENG
35Drotrecogin alfa1110.4F5, THBD
36methionine4410.4MTRR, MTHFR, BHMT, THBD, SLC19A1
37bivalirudin44 1111.4F5, THBD
38fibrinogen4410.3F5, MTHFR, PROC, EPHA1, THBD
39ascorbic acid44 2411.3F5, MT3, MTHFR, THBD, NOS3, ENG
40pteridine4410.3SLC19A1, NOS3
41homocysteine44 2411.2NOS3, F5, MTRR, MTHFR, BHMT, THBD
42folate4410.2F5, MTRR, MTHFR, BHMT, THBD, SLC19A1
43argatroban44 1111.2THBD, F5
44aspartate4410.2APEH, TFPI2, F5, MTRR, MTHFR, THBD
45vegf4410.2F5, EPHA1, PGF, THBD, NOS3, ENG
46nitric oxide44 11 2412.2F5, MTRR, EPHA1, PGF, THBD, NOS3
47thymidylate4410.2SLC19A1, MTHFR, MTRR
48alanine4410.1APEH, F5, MTRR, MTHFR, THBD, SLC19A1
49cysteine4410.0ENG, APEH, F5, MT3, MTHFR, BHMT
50azathioprine44 49 2 1112.9MTHFR, THBD, NOS3

GO Terms for genes affiliated with Placental Abruption

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16Gene Ontology
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Biological processes related to Placental Abruption according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:01054410.4NOS3, THBD
2folic acid metabolic processGO:04665510.4SLC19A1, MTHFR
3methionine biosynthetic processGO:00908610.4BHMT, MTHFR, MTRR
4negative regulation of blood coagulationGO:03019510.3THBD, PROC
5female pregnancyGO:00756510.2PZP, PGF, THBD
6water-soluble vitamin metabolic processGO:00676710.2MTRR, MTHFR, SLC19A1
7blood coagulationGO:00759610.1TFPI2, F5, PROC, THBD, NOS3
8vitamin metabolic processGO:00676610.1MTRR, MTHFR, SLC19A1
9positive regulation of angiogenesisGO:0457669.8NOS3, PGF, EPHA1

Molecular functions related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1FMN bindingGO:01018110.3NOS3, MTRR
2NADPH-hemoprotein reductase activityGO:00395810.2NOS3, MTRR
3cadmium ion bindingGO:04687010.0NOS3, MT3

Products for genes affiliated with Placental Abruption

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Sources for Placental Abruption

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet