MCID: PLC007
MIFTS: 46

Placental Abruption malady

Summaries for Placental Abruption

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Disease Ontology:10 A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

MalaCards based summary: Placental Abruption, also known as abruptio placentae, is related to pre-eclampsia and eclampsia. An important gene associated with Placental Abruption is BHMT (betaine--homocysteine S-methyltransferase), and among its related pathways are Cell surface interactions at the vascular wall and Hemostasis. The compounds cystathionine and vitamin b12 have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and heart, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Wikipedia:65 Placental abruption (also known as abruptio placentae) is a complication of pregnancy, wherein the... more...

Aliases & Classifications for Placental Abruption

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Placental Abruption, Aliases & Descriptions:

Name: Placental Abruption 10 11 12 62
Abruptio Placentae 10 45 62
 
Abruptio Placentae, Susceptibility to 11
Abruptio Placenta 10


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Disease Ontology10 DOID:9667
ICD9CM29 640.0
MeSH35 D000033

Related Diseases for Placental Abruption

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Graphical network of the top 20 diseases related to Placental Abruption:



Diseases related to placental abruption

Symptoms for Placental Abruption

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Drugs & Therapeutics for Placental Abruption

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Drug clinical trials:

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Search NIH Clinical Center for Placental Abruption

Genetic Tests for Placental Abruption

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Anatomical Context for Placental Abruption

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MalaCards organs/tissues related to Placental Abruption:

33
Placenta, Uterus, Heart, Testes, Endothelial, Spleen, Brain, Retina

Animal Models for Placental Abruption or affiliated genes

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MGI Mouse Phenotypes related to Placental Abruption:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.2PROC, HLA-G, EBAG9, THBD
2MP:00053708.0F5, BHMT, PROC, THBD
3MP:00053767.3THBD, HLA-G, PROC, BHMT, F5

Publications for Placental Abruption

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Articles related to Placental Abruption:

(show top 50)    (show all 298)
idTitleAuthorsYear
1
Abnormal patterns of blood flow through the uterine arteries: Is it a clue for placental abruption in clinically suspected cases? (25774964)
2015
2
Intrapartum anti-disseminated intravascular coagulation therapy leading to successful vaginal delivery following intrauterine fetal death caused by placental abruption: a case report. (25532532)
2014
3
Is there an association between a history of placental abruption and long-term maternal renal complications? (25234099)
2014
4
Predictors of perinatal mortality associated with placenta previa and placental abruption: an experience from a low income country. (25002975)
2014
5
Risk factors of placental abruption. (24174950)
2013
6
Decreasing perinatal mortality in placental abruption. (23072758)
2013
7
Placenta praevia, placental abruption and amphetamine use in pregnancy: a case study. (23266230)
2013
8
The ability of computed tomography to diagnose placental abruption in the trauma patient. (23271100)
2013
9
MR imaging in the evaluation of placental abruption: correlation with sonographic findings. (21330568)
2011
10
Two cases of angular pregnancy complicated by preterm labor and placental abruption at mid-pregnancy. (21450029)
2011
11
Is the perinatal outcome of placental abruption modified by clinical presentation? (21490793)
2011
12
Hysterotomy and evacuation of a deciduate placental hematoma following placental abruption. (20624620)
2010
13
Self-reported smoking habits and serum cotinine levels in women with placental abruption. (21050148)
2010
14
Maternal deaths in Finland: focus on placental abruption. (19707898)
2009
15
Pre-eclampsia, placental abruption and increased risk of atopic sensitization in male adolescent offspring. (19811463)
2009
16
The increase in metallothionein and ectopic decidual immunoreactivity with respect to the progression of labor at term and the lack of analogical changes in placental abruption. (18782281)
2008
17
Low birthweight in relation to placental abruption and maternal thrombophilia status. (18191809)
2008
18
Folic acid and multivitamin supplement use and risk of placental abruption: a population-based registry study. (18187445)
2008
19
Failure of second-trimester measurement of soluble endoglin and other angiogenic factors to predict placental abruption. (17960788)
2007
20
Risk and risk estimation of placental abruption. (16202500)
2006
21
Uterine torsion with placental abruption. (16483985)
2006
22
Placental abruption in term and preterm gestations: evidence for heterogeneity in clinical pathways. (16582113)
2006
23
Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in Finnish women. (16260885)
2005
24
Anti-fetal immune response mechanisms may be involved in the pathogenesis of placental abruption. (14962795)
2004
25
Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption. (15582499)
2004
26
Could placental abruption be an antiphospholipid antibody related disorder? (15144143)
2004
27
Sucessful pregnancy outcome following three severe placental abruptions and intrauterine fetal death in the patient--heterozygous carrier of R506Q mutation of factor V (Leiden)]. (15518286)
2004
28
Interventions for treating placental abruption. (12535464)
2003
29
Placental abruption is associated with decreased maternal plasma levels of soluble HLA-G. (12959223)
2003
30
Clinical utility of sonography in the diagnosis and treatment of placental abruption. (12164566)
2002
31
Thrombin-enhanced matrix metalloproteinase-1 expression: a mechanism linking placental abruption with premature rupture of the membranes. (12380602)
2002
32
Placental abruption. (11997676)
2002
33
The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption. (11354626)
2001
34
Sonolucency of a fresh hematoma in a case of marginal placental abruption. (11451559)
2001
35
Placental abruption and adverse perinatal outcomes. (10553791)
1999
36
Is fetal gender significant in the perinatal outcome of pregnancies complicated by placental abruption? (15512413)
1999
37
Thrombomodulin: a new marker for placental abruption. (9974370)
1999
38
Preterm labor, placental abruption, and premature rupture of membranes in relation to maternal violence or verbal abuse. (10338059)
1999
39
Plasma fibrin D-dimer in pregnancies complicated by partial placental abruption. (9323905)
1997
40
Maternal serum alpha-fetoprotein in placental abruption associated with preterm labor. (9127154)
1997
41
Influence of hypertensive disorders and cigarette smoking on placental abruption and uterine bleeding during pregnancy. (9166200)
1997
42
Placental abruption following placement of disposable intrauterine pressure transducer system. (8442792)
1993
43
Conservative management of placental abruption complicated by severe clotting disorders. (1426497)
1992
44
Feto-pelvic disproportion of mimicking placental abruption. (2102210)
1990
45
Pulmonary thromboembolism complicating recurrent placental abruption at 29 weeks' gestation. (2400355)
1990
46
Uteroplacental and umbilical artery blood velocity waveforms in placental abruption assessed by Doppler ultrasound. (2930753)
1989
47
Placental abruption associated with cocaine abuse. (3285653)
1988
48
Placental abruption and subchorionic hemorrhage in the first half of pregnancy: US appearance and clinical outcome. (3520643)
1986
49
Case report: ruptured spleen, placental abruption and toxemia of pregnancy. Simultaneous complications of pregnancy. (927413)
1977
50
Pathogenesis of hypofibrinogenemia in placental abruption. (13674508)
1959

Variations for Placental Abruption

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Expression for genes affiliated with Placental Abruption

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Search GEO for disease gene expression data for Placental Abruption.

Pathways for genes affiliated with Placental Abruption

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Compounds for genes affiliated with Placental Abruption

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Compounds related to Placental Abruption according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1cystathionine459.8F5, BHMT
2vitamin b12459.7F5, BHMT
3hirugen459.5F5, THBD
4ximelagatran45 1310.5THBD, F5
5ancrod459.5THBD, F5
6heparinoids459.5F5, THBD
7fondaparinux459.4F5, THBD
8bivalirudin45 1310.4THBD, F5
9argatroban45 1310.4THBD, F5
10cacl2459.4F5, THBD
11benzamidine45 1310.4THBD, F5
12neopterin459.4HLA-G, THBD
13desmopressin45 61 30 1312.4F5, THBD
14cardiolipin45 1310.4THBD, F5
15hirudin459.4F5, THBD
16mycophenolate mofetil45 51 1311.4THBD, F5
17dermatan sulfate459.4F5, THBD
18raloxifene45 51 30 1312.4F5, THBD
19kininogen459.3THBD, F5
20urea45 26 1311.3HLA-G, F5
21tunicamycin45 6110.3F5, THBD
22pge1459.3F5, THBD
23aprotinin45 1310.3THBD, F5
24polyethylene glycol459.2F5, THBD
25vitamin-e459.2THBD, F5
26atorvastatin45 51 30 26 1313.1F5, THBD
27vitamin b6459.1F5, BHMT, THBD
28homocysteine45 2610.1F5, BHMT, THBD
29folate459.0F5, BHMT, THBD
30simvastatin45 51 61 30 26 1314.0F5, THBD
31gamma-carboxyglutamic acid459.0F5, PROC, THBD
32warfarin45 51 26 1311.9THBD, PROC, F5
33citrate458.9F5, THBD
34fibrinogen458.9THBD, PROC, F5
35phospholipid458.9F5, PROC, THBD
36lactate458.9F5, HLA-G, THBD
37creatinine458.8THBD, HLA-G, F5
38leucine458.8F5, HLA-G, THBD
39agarose458.8HLA-G, THBD
40heparin45 30 26 1311.8THBD, PROC, F5
41progesterone45 30 61 26 1312.8THBD, HLA-G, F5
42cholesterol45 30 26 1311.7F5, HLA-G, THBD
43vegf458.6F5, HLA-G, THBD
44cysteine458.5F5, BHMT, HLA-G, THBD
45serine458.4F5, BHMT, PROC, THBD

GO Terms for genes affiliated with Placental Abruption

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Cellular components related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058867.5F5, PROC, HLA-G, EBAG9, THBD

Biological processes related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1leukocyte migrationGO:00509009.1PROC, THBD
2negative regulation of blood coagulationGO:00301959.0PROC, THBD
3blood coagulationGO:00075968.2F5, PROC, THBD

Molecular functions related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042529.3F5, PROC

Products for genes affiliated with Placental Abruption

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Sources for Placental Abruption

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet