MCID: PLC007
MIFTS: 51

Placental Abruption malady

Summaries for Placental Abruption

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

MalaCards: Placental Abruption, also known as abruptio placentae, is related to eclampsia and thrombophilia. An important gene associated with Placental Abruption is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are Common Pathway and Complement and coagulation cascades. The compounds warfarin and glutamate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and spleen, and related mouse phenotypes are integument and embryogenesis.

Wikipedia:64 Placental abruption (also known as abruptio placentae) is a complication of pregnancy, wherein the... more...

Aliases & Classifications for Placental Abruption

Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

placental abruption 8 9 47 10
abruptio placentae 8 47 45 61
abruptio placentae, susceptibility to 9


External Ids:

Disease Ontology8 DOID:9667
ICD9CM27 640.0
MeSH35 D000033

Related Diseases for Placental Abruption

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Placental Abruption via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia30.8THBD, MTHFR
2thrombophilia30.6F5, MTHFR, PROC, THBD
3deficiency anemia30.3ENG
4myelomeningocele30.3MTHFR
5hellp syndrome30.2MTHFR, F5
6acute leukemia30.2MTHFR
7thrombocytopenia30.2THBD, F5
8dysfibrinogenemia30.2F5, THBD
9venous thrombosis30.2F5, MTHFR, PROC, THBD
10sepsis30.2NOS3, THBD, PROC, F5
11thromboembolism30.2F5, MTHFR, PROC, THBD, NOS3
12hyperhomocysteinemia30.2F5, MTRR, MTHFR, BHMT, THBD, SLC19A1
13supine hypotensive syndrome10.4
14chorioamnionitis10.4
15afibrinogenemia10.4
16cocaine abuse10.3
17pregnancy loss10.3
18paralytic ileus10.2
19anuria10.2
20iron deficiency anemia10.2
21ileus10.2
22chorioangioma10.1
23pseudotumor cerebri10.1
24tuberous sclerosis10.1
25placental site trophoblastic tumor10.1
26diabetes insipidus10.1
27listeriosis10.1
28hemolytic-uremic syndrome10.1
29angiomyolipoma10.1
30acute promyelocytic leukemia10.1
31head injury10.1
32headache10.1
33didelphys uterus10.1
34galactosemia10.0F5
35arthritis10.0PGF
36vascular disease10.0THBD
37meningioma10.0PGF
38cerebrovascular disease10.0MTHFR
39cholangiocarcinoma10.0EBAG9
40malaria10.0MRPL28
41hereditary hemorrhagic telangiectasia10.0ENG
42branch retinal artery occlusion10.0F5
43osteosarcoma10.0SLC19A1
44hepatopulmonary syndrome10.0NOS3
45thrombocytosis10.0THBD
46retinal vascular occlusion10.0F5
47homocysteinemia10.0MTHFR, F5
48amyotrophic lateral sclerosis10.0MT3
49malignant mesothelioma10.0THBD
50purpura fulminans10.0F5, PROC

Graphical network of the top 20 diseases related to Placental Abruption:



Diseases related to placental abruption

Clinical Features for Placental Abruption

Drugs & Therapeutics for Placental Abruption

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Placental Abruption

Drug clinical trials:

Search ClinicalTrials for Placental Abruption

Search NIH Clinical Center for Placental Abruption

Search CenterWatch for Placental Abruption

Genetic Tests for Placental Abruption

Anatomical Context for Placental Abruption

Sources:
33MalaCards
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MalaCards organs/tissues related to Placental Abruption:

33
Spinal cord, Brain, Spleen, Uterus, Retina, Heart, Placenta, Endothelial, Fetal brain

Animal Models for Placental Abruption or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Placental Abruption:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.8ENG, SLC19A1, PZP
2MP:00053809.7THBD, NOS3, F5, PZP, ENG, PGF
3MP:00053709.7SLC19A1, THBD, NOS3, BHMT, PROC, F5
4MP:00053789.2EPHA1, THBD, SLC19A1, ENG, PGF, BHMT
5MP:00053769.1PZP, ENG, NOS3, THBD, PGF, EPHA1

Publications for Placental Abruption

Sources:
51PubMed
See all sources

Articles related to Placental Abruption:

(show top 50)    (show all 271)
idTitleAuthorsYear
1
Capable of identifying risk factors for placental abruption. (23617603)
2014
2
Risk factors of placental abruption. (24174950)
2013
3
Placental abruption and placental weight - implications for fetal growth. (23750805)
2013
4
Prediction of fetal acidemia in placental abruption. (23915223)
2013
5
Genome-wide and candidate gene association studies of placental abruption. (24046805)
2013
6
Placental abruption and fetal demise secondary to placental metastases from unknown primary: a case report. (23947085)
2013
7
Increased prevalence of major congenital anomalies in births with placental abruption. (23969794)
2013
8
Listeriosis in pregnancy with placental abruption. (22779970)
2012
9
Case report: lethal fetal head injury and placental abruption in a pregnant trauma patient. (22237696)
2012
10
A genome-wide association study of variations in maternal cardiometabolic genes and risk of placental abruption. (23205182)
2012
11
Is the perinatal outcome of placental abruption modified by clinical presentation? (21490793)
2011
12
Alcohol consumption during pregnancy and risk of placental abruption and placenta previa. (20437196)
2011
13
Risk for placental abruption following amniocentesis and chorionic villus sampling. (21413037)
2011
14
Extreme obesity and risk of placental abruption. (19049991)
2009
15
Comparison of maternal risk factors between placental abruption and placenta previa. (19021090)
2009
16
The effect of maternal thrombophilia on placental abruption: Histologic correlates. (19330709)
2009
17
Maternal pre-gravid body weight and risk for placental abruption among twin pregnancies. (19488950)
2009
18
Thromboembolic diseases in families of women with placental abruption. (19535986)
2009
19
CT evaluation of placental abruption in pregnant trauma patients. (19277736)
2009
20
The increase in metallothionein and ectopic decidual immunoreactivity with respect to the progression of labor at term and the lack of analogical changes in placental abruption. (18782281)
2008
21
Reduced folate carrier 80A-->G polymorphism, plasma folate, and risk of placental abruption. (18629538)
2008
22
Prediction of placental abruption by testing for C-reactive protein and chlamydial antibody levels in early pregnancy. (18271885)
2008
23
Acute promyelocytic leukemia: an unusual cause showing prolonged disseminated intravascular coagulation after placental abruption. (17713776)
2008
24
Elevated maternal second-trimester serum alpha-fetoprotein as a risk factor for placental abruption. (17238224)
2007
25
Indications of anti-HY immunity in recurrent placental abruption. (17434600)
2007
26
Placental abruption. (17012465)
2006
27
Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in Finnish women. (16260885)
2005
28
M385T polymorphism in the factor V gene, but not Leiden mutation, is associated with placental abruption in Finnish women. (15450391)
2004
29
Preterm premature rupture of membranes, intrauterine infection, and oligohydramnios: risk factors for placental abruption. (15229003)
2004
30
The profile and complications of women with placental abruption and intrauterine death. (12929885)
2003
31
Clinical utility of sonography in the diagnosis and treatment of placental abruption. (12164566)
2002
32
Haemoperitoneum due to placenta percreta in the third trimester mimicking placental abruption. (12554272)
2002
33
The injury severity score in pregnant trauma patients: predicting placental abruption and fetal death. (12435948)
2002
34
Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review. (10452905)
1999
35
Activated protein C is effective for disseminated intravascular coagulation associated with placental abruption. (10544932)
1999
36
Incidence of placental abruption in relation to cigarette smoking and hypertensive disorders during pregnancy: a meta-analysis of observational studies. (10214847)
1999
37
Perinatal mortality and case fatality after placental abruption in Norway 1967-1991. (8607334)
1996
38
Lupus anticoagulant and HELLP syndrome complicated by placental abruption, hepatic, dermal and adrenal infarction. (7677696)
1995
39
Neonatal intracranial lesions following placental abruption. (8181506)
1994
40
Conservative management of placental abruption complicated by severe clotting disorders. (1426497)
1992
41
Placental bed biopsies in placental abruption. (1390469)
1992
42
Delayed cesarean section in preeclampsia with placental abruption and fetal distress. (1890480)
1991
43
Placental abruption. A case-control investigation. (2059590)
1991
44
Fetal and uteroplacental flow velocity waveforms in the expectant management of placental abruption. (2227614)
1990
45
Placental abruption in the preterm gestation: an association with chorioamnionitis. (2733948)
1989
46
Placental abruption associated with cocaine abuse. (3285653)
1988
47
Occult placental abruption after maternal trauma. (3347433)
1988
48
Placental abruption and subchorionic hemorrhage in the first half of pregnancy: US appearance and clinical outcome. (3520643)
1986
49
Case report: ruptured spleen, placental abruption and toxemia of pregnancy. Simultaneous complications of pregnancy. (927413)
1977
50
Anencephalus, hydramnios and placental abruption. (5336849)
1967

Genetic Variations for Placental Abruption

Expression for genes affiliated with Placental Abruption

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Placental Abruption

Search GEO for disease gene expression data for Placental Abruption.

Pathways for genes affiliated with Placental Abruption

Sources:
54Reactome, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Compounds for genes affiliated with Placental Abruption

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
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Compounds related to Placental Abruption according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1warfarin45 50 11 2413.8PROC
2glutamate4510.7MT3, THBD
3hirugen4510.7THBD, F5
4raloxifene45 29 50 1113.7NOS3, F5
5betaine45 2411.6BHMT, MTHFR, MTRR
6gamma-carboxyglutamic acid4510.6THBD, PROC, F5
7tetrahydrofolate4510.6SLC19A1, MTHFR, MTRR
8riboflavin45 11 2412.6BHMT, MTHFR, MTRR
9ancrod4510.6F5, THBD
10b vitamins4510.6MTRR, MTHFR
11ximelagatran45 1111.6F5, THBD
12methylcobalamin45 2411.6MTRR, MTHFR
13heparinoids4510.6THBD, F5
14vitamin b64510.5THBD, BHMT, MTHFR, F5
15fondaparinux4510.5THBD, F5
16cystathionine4510.5BHMT, MTHFR, MTRR, F5
17serine4510.5APEH, TFPI2, BHMT
18matrigel4510.5TFPI2, PGF, NOS3
195-methyltetrahydrofolate45 1111.5F5, MTRR, MTHFR, SLC19A1
20vitamin b124510.5F5, MTRR, MTHFR, BHMT
21heparin45 29 11 2413.5PGF, MTHFR, TFPI2
22creatinine4510.5F5, MT3, THBD
23cyanocobalamin50 11 2412.5MTRR, MTHFR
24cyclophosphamide45 50 1112.5F5, MTHFR, THBD, NOS3
25hydroxocobalamin45 1111.5MTRR, MTHFR
26atorvastatin45 50 29 11 2414.5NOS3, THBD, PGF, F5
27s-adenosylmethionine45 11 2412.5SLC19A1, BHMT, MTHFR, MTRR
2810-formyltetrahydrofolate4510.4MTHFR, SLC19A1
29tunicamycin45 6011.4F5, THBD, SLC19A1
30prostacyclin4510.4F5, PGF, THBD, NOS3
31aspirin45 50 29 2413.4F5, MTHFR, THBD, NOS3
32mercaptopurine50 1111.4MTHFR, SLC19A1
33methotrexate45 50 1112.4NOS3, SLC19A1, MTHFR, MTRR
34p0024510.4TFPI2, F5, MTHFR, ENG
35Drotrecogin alfa1110.4F5, THBD
36methionine4510.4MTRR, MTHFR, BHMT, THBD, SLC19A1
37bivalirudin45 1111.4F5, THBD
38fibrinogen4510.3F5, MTHFR, PROC, EPHA1, THBD
39ascorbic acid45 2411.3F5, MT3, MTHFR, THBD, NOS3, ENG
40pteridine4510.3SLC19A1, NOS3
41homocysteine45 2411.2NOS3, F5, MTRR, MTHFR, BHMT, THBD
42folate4510.2F5, MTRR, MTHFR, BHMT, THBD, SLC19A1
43argatroban45 1111.2THBD, F5
44aspartate4510.2APEH, TFPI2, F5, MTRR, MTHFR, THBD
45vegf4510.2F5, EPHA1, PGF, THBD, NOS3, ENG
46nitric oxide45 11 2412.2F5, MTRR, EPHA1, PGF, THBD, NOS3
47thymidylate4510.2SLC19A1, MTHFR, MTRR
48alanine4510.1APEH, F5, MTRR, MTHFR, THBD, SLC19A1
49cysteine4510.0ENG, APEH, F5, MT3, MTHFR, BHMT
50azathioprine45 50 2 1112.9MTHFR, THBD, NOS3

GO Terms for genes affiliated with Placental Abruption

Sources:
16Gene Ontology
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Biological processes related to Placental Abruption according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:01054410.4NOS3, THBD
2folic acid metabolic processGO:04665510.4SLC19A1, MTHFR
3methionine biosynthetic processGO:00908610.4BHMT, MTHFR, MTRR
4negative regulation of blood coagulationGO:03019510.3THBD, PROC
5female pregnancyGO:00756510.2PZP, PGF, THBD
6water-soluble vitamin metabolic processGO:00676710.2MTRR, MTHFR, SLC19A1
7blood coagulationGO:00759610.1TFPI2, F5, PROC, THBD, NOS3
8vitamin metabolic processGO:00676610.1MTRR, MTHFR, SLC19A1
9positive regulation of angiogenesisGO:0457669.8NOS3, PGF, EPHA1

Molecular functions related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1FMN bindingGO:01018110.3NOS3, MTRR
2NADPH-hemoprotein reductase activityGO:00395810.2NOS3, MTRR
3cadmium ion bindingGO:04687010.0NOS3, MT3

Products for genes affiliated with Placental Abruption

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  • Proteins
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Sources for Placental Abruption

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet