MCID: PLC007
MIFTS: 50

Placental Abruption

Categories: Fetal diseases

Aliases & Classifications for Placental Abruption

MalaCards integrated aliases for Placental Abruption:

Name: Placental Abruption 12 72 14
Abruptio Placentae 12 51 69
Abortion, Threatened 41
Abruptio Placenta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9667
ICD10 32 O20.0
ICD9CM 34 640.0 640.03
MeSH 41 D000033
NCIt 46 C112857

Summaries for Placental Abruption

Disease Ontology : 12 A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

MalaCards based summary : Placental Abruption, also known as abruptio placentae, is related to disseminated intravascular coagulation and severe pre-eclampsia. An important gene associated with Placental Abruption is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Collagen chain trimerization and Formation of Fibrin Clot (Clotting Cascade). The drugs Methyldopa and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Placental abruption is when the placenta separates early from the uterus, in other words separates... more...

Related Diseases for Placental Abruption

Diseases related to Placental Abruption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 disseminated intravascular coagulation 30.0 F2 F5 SERPINC1 THBD
2 severe pre-eclampsia 29.5 APOH F5 PGF SERPINC1
3 dysfibrinogenemia 29.4 F2 F5 SERPINC1 THBD
4 thrombophilia 29.2 APOH F2 F5 MTHFR SERPINC1 THBD
5 thrombosis 28.8 APOH F2 F5 MTHFR SERPINC1 THBD
6 eclampsia 28.2 ENG F2 F5 FLT1 MTHFR PGF
7 pre-eclampsia 27.4 AGT APOH ENG F2 F5 FLT1
8 hellp syndrome 27.1 APOH ENG F2 F5 FLT1 MTHFR
9 kidney cortex necrosis 11.2
10 inferior vena cava interruption 10.5 F5 MTHFR
11 paracetamol poisoning 10.5 F2 F5
12 amaurosis fugax 10.5 F5 MTHFR
13 may-thurner syndrome 10.5 APOH F5
14 mesenteric vascular occlusion 10.5 F2 MTHFR
15 acanthamoeba keratitis 10.5 APOH F5
16 hemoglobin e disease 10.5 F2 F5
17 ischemic neuropathy 10.4 F2 MTHFR
18 factor viii deficiency 10.4 F2 F5
19 splenic infarction 10.4 APOH F2
20 papilledema 10.4 APOH F2
21 factor v deficiency 10.3 F2 F5
22 cryptogenic cirrhosis 10.3 F2 F5 MTHFR
23 porencephaly 10.3 F2 F5 MTHFR
24 arteritic anterior ischemic optic neuropathy 10.3 F2 F5 MTHFR
25 thrombasthenia 10.3 F2 F5 MTHFR
26 sticky platelet syndrome 10.3 F5 SERPINC1
27 pregnancy loss, recurrent 1 10.3 APOH F5 MTHFR
28 catastrophic antiphospholipid syndrome 10.3 APOH F5 MTHFR
29 intestinal impaction 10.3 F2 SERPINC1
30 cerebral sinovenous thrombosis 10.3 APOH F2 F5
31 fournier gangrene 10.3 F2 SERPINC1
32 cerebral palsy 10.3 F2 F5 MTHFR
33 leech infestation 10.3 F2 SERPINC1
34 alpha-2-plasmin inhibitor deficiency 10.3 F2 SERPINC1
35 buerger disease 10.3 APOH F2 MTHFR
36 giant hemangioma 10.3 F2 SERPINC1
37 cerebrovascular disease 10.3 F2 F5 MTHFR
38 blue toe syndrome 10.3 F2 SERPINC1
39 intracranial embolism 10.2 F2 SERPINC1
40 anterior spinal artery syndrome 10.2 F2 SERPINC1
41 subendocardial myocardial infarction 10.2 F2 SERPINC1
42 scott syndrome 10.2 F2 F5
43 mild pre-eclampsia 10.2 FLT1 PGF
44 vaginitis 10.2
45 epithelioid hemangioendothelioma 10.2 FLT1 PGF
46 cancer-associated retinopathy 10.2 FLT1 PGF
47 purpura fulminans 10.2 F2 SERPINC1
48 carotid artery occlusion 10.2 APOH F5 THBD
49 esophageal varix 10.2 F2 SERPINC1
50 raynaud disease 10.2 APOH THBD

Graphical network of the top 20 diseases related to Placental Abruption:



Diseases related to Placental Abruption

Symptoms & Phenotypes for Placental Abruption

MGI Mouse Phenotypes related to Placental Abruption:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 SERPINC1 THBD F2 PGF F5 AGT
2 homeostasis/metabolism MP:0005376 10.06 SERPINC1 THBD F2 MTHFR PGF F5
3 growth/size/body region MP:0005378 10.02 THBD ENG MTHFD1 MTHFR F2 PGF
4 embryo MP:0005380 10.01 SERPINC1 THBD F2 PGF F5 FLT1
5 immune system MP:0005387 9.86 THBD SERPINC1 MTHFD1 F2 PGF AGT
6 mortality/aging MP:0010768 9.65 SERPINC1 THBD ENG MTHFD1 MTHFR F2
7 integument MP:0010771 9.63 THBD ENG MTHFR F2 PGF F5
8 nervous system MP:0003631 9.28 SERPINC1 THBD MTHFD1 MTHFR F2 F5

Drugs & Therapeutics for Placental Abruption

Drugs for Placental Abruption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 113)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4 555-30-6 38853
2
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-56-6 53477758 439302
3
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
4
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3 7487-88-9 24083
5 Analgesics Phase 4,Phase 3,Phase 2
6 Tocolytic Agents Phase 4,Phase 3,Phase 2
7 Oxytocics Phase 4,Phase 3,Phase 2,Phase 1
8 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
9 Antihypertensive Agents Phase 4
10 Calcium, Dietary Phase 4,Phase 3,Phase 2
11 calcium channel blockers Phase 4,Phase 3
12 Central Nervous System Depressants Phase 4,Phase 3,Phase 1
13 Clindamycin palmitate Phase 4
14 Clindamycin phosphate Phase 4
15 Anesthetics Phase 4,Phase 3,Phase 1
16 Anti-Arrhythmia Agents Phase 4,Phase 3
17 Anti-Bacterial Agents Phase 4
18 Anticonvulsants Phase 4,Phase 3
19 Anti-Infective Agents Phase 4,Phase 3
20
Aspirin Approved, Vet_approved Phase 3,Phase 2 50-78-2 2244
21
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
22
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
23
Tranexamic Acid Approved Phase 3 1197-18-8 5526
24
Hydroxocobalamin Approved Phase 3 13422-51-0 5460373 44475014 11953898
25
Dalteparin Approved Phase 3 9005-49-6
26
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
27
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
28
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
29
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
30
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 3 65-23-6 1054
31
Biotin Approved, Investigational, Nutraceutical Phase 3 58-85-5 171548
32
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 3 83-88-5 493570
33
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 54670067 5785
34
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 3 59-43-8 1130
35
Pyridoxal Approved, Nutraceutical Phase 3 66-72-8 1050
36 Tocopherol Approved, Investigational, Nutraceutical Phase 3
37
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 3 13422-55-4
38
Cyanocobalamin Approved, Nutraceutical Phase 3 68-19-9 44176380
39
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
40 Fibrinolytic Agents Phase 3,Phase 2
41 Micronutrients Phase 3
42 Coagulants Phase 3
43 Trace Elements Phase 3
44 Hematinics Phase 3
45 Cyclooxygenase Inhibitors Phase 3,Phase 2
46 Analgesics, Non-Narcotic Phase 3,Phase 2
47 Vasodilator Agents Phase 3,Phase 2
48 Vitamin B Complex Phase 3
49 Hormones Phase 3
50 Vitamins Phase 3

Interventional clinical trials:

(show top 50) (show all 54)

# Name Status NCT ID Phase Drugs
1 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4 methildopa;placebo
2 Induction of Labor With a Foley Balloon Catheter: Inflation With 30ml Compared to 60ml Completed NCT00451308 Phase 4
3 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
4 Foley Bulb With Low Dose Pitocin Versus Foley Bulb With a Standard Incremental Infusion Protocol for the Induction of Labor Completed NCT02150954 Phase 4 pitocin
5 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
6 Folic Acid Dosage and Malformations Reduction Unknown status NCT01244347 Phase 3 folic acid;folic acid
7 Low Dose Aspirin for the Prevention of Preeclampsia Unknown status NCT01890005 Phase 3 Aspirin;Placebo
8 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
9 Syringe or Continuous Amnioreduction for Symptomatic Polyhydramnios. A Prospective Randomized Study. Completed NCT00236340 Phase 3
10 Can we Use Intravenous Injection of Tranexamic Acid in Routine Practice With Active Management of the Third Stage of Labor? Completed NCT01338454 Phase 3 transamin
11 Intraumbilical Vein Injection of Oxytocin in Routine Practice for Active Management of the Third Stage of Labor Completed NCT01094028 Phase 3 Oxytocin
12 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
13 Low Molecular Weight Heparin and/or Aspirin in Prevention of Habitual Abortion Completed NCT00959621 Phase 3 Aspirin;Klexane;Klexane and ASA
14 TIPPS: Thrombophilia in Pregnancy Prophylaxis Study Completed NCT00967382 Phase 3 dalteparin sodium
15 Controlled Cord Traction During Third Stage of Labor Completed NCT00781066 Phase 3
16 Effectiveness of Dalteparin Therapy as Intervention in Recurrent Pregnancy Loss Completed NCT00400387 Phase 3 Fragmin P Forte (dalteparin sodium)
17 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
18 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3 Folic Acid 4 mg;Placebo
19 RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil Completed NCT00097110 Phase 3 Vitamin C and E
20 Low Dose Aspirin in the Prevention of Preeclampsia in China Recruiting NCT02797249 Phase 3 Aspirin
21 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
22 Utility of Tocolytic Therapy for Maintenance Tocolysis in the Management of Threatened Preterm Delivery Withdrawn NCT01796522 Phase 3 progesterone 200 mg / day vaginally;nifedipine (60 mg / day orally)
23 Sildenafil Citrate for the Management of Asymmetrical Intrauterine Growth Restriction Unknown status NCT02678221 Phase 2 Sildenafil citrate;Aspirin
24 Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM) Unknown status NCT00466128 Phase 2 indomethacin
25 Impact of the NO-donor Pentaerythrithyltetrantrate on Perinatal Outcome in High-risk Pregnancies Completed NCT01355822 Phase 1, Phase 2 PETN;Placebo control
26 Intraumbilical Oxytocin Versus Placental Cord Drainage in the Management of 3rd Stage of Labor Recruiting NCT03395730 Phase 2 Intraumbilical vein injection oxytocin
27 Prophylactic Use of Intraumbilical Vein Oxytocin Injection in The Management of Third Stage of Labor Unknown status NCT02680938 Phase 1 oxytocin;saline
28 Spinal Analgesia Versus No Analgesia: Study for External Cephalic Version Terminated NCT00119184 Phase 1 spinal anesthesia
29 Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity Unknown status NCT00573118
30 Prediction of Preeclampsia & Other Obstetric Complications by Serum Homocysteine & Doppler Unknown status NCT02541110
31 Relation Between Subclinical Hypothyroidism and Outcome of Pregnancy Unknown status NCT01335802
32 Haptoglobin and Diabetes Complications in Pregnancy Unknown status NCT01758016
33 Comparison of Efficiency Between Practicing of Knee Chest Position and External Cephalic Version in Cases of Breech Presentation. Unknown status NCT02167841
34 Pre-Eclampsia Prediction By Doppler Screening Of Uterine Arteries And Angiogenic Factors In Second Trimester Of Pregnancy Unknown status NCT00725660
35 The Prognosis of Early Pregnancy With Post Coital Bleeding Unknown status NCT02363569
36 İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? Unknown status NCT01906567
37 Magnesium Sulfate vs Placebo for Placental Abruption Completed NCT00186069 Magnesium Sulfate
38 Prevention of Post-partum Haemorrhage Completed NCT01044082
39 Comparing Blood Loss During Caesarean Section Between Manual Separation of Placenta & Conservative Management Completed NCT02480556
40 Dose Adjusting Enoxaparin Thromboprophylaxis Dosage According to Anti-factor Xa Plasma Levels Improve Pregnancy Outcome Completed NCT01068795 enoxaparin
41 Early Prevention of Preeclampsia Study Completed NCT01547390 Aspirin;placebo
42 The Reduced Thyroid Function of the Premature Newborn: Relation With Molecular Changes in the Placenta and Maternal Thyroid Hormone Status and Neurodevelopmental Implications Completed NCT01466023
43 The Prognostic Value of PGF and sFlt1 Variations Induced by the First Low-molecular-weight-heparin Injections in Women With Obstetrical Antiphospholipids Antibody Syndrome Starting a New Pregnancy and Following Treatment in Accordance With International R Completed NCT02855047
44 Induction of Labor in Intrahepatic Cholestasis of Pregnancy Completed NCT01381939
45 Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women Completed NCT03154268
46 Induction Versus Expectant Management With Abnormal Maternal Biochemical Markers Recruiting NCT02754635
47 Omission of Controlled Cord Traction During Active Management of Third Stage of Labor Recruiting NCT02656108
48 Delayed Clamping and Milking the Umbilical Cord in Preterm Infants Recruiting NCT02092103
49 China Obstetrics Alliance Cohort Study Enrolling by invitation NCT03038555
50 Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia Not yet recruiting NCT03171480 Monoket Pill

Search NIH Clinical Center for Placental Abruption

Cochrane evidence based reviews: abortion, threatened

Genetic Tests for Placental Abruption

Anatomical Context for Placental Abruption

MalaCards organs/tissues related to Placental Abruption:

38
Placenta, Uterus, Kidney, Testes, Thyroid, Liver, Heart

Publications for Placental Abruption

Articles related to Placental Abruption:

(show top 50) (show all 357)
# Title Authors Year
1
Meta-analysis on the effect of aspirin use for prevention of preeclampsia on placental abruption and antepartum hemorrhage. ( 29305829 )
2018
2
Heat and pregnancy-related emergencies: Risk of placental abruption during hot weather. ( 29146008 )
2018
3
Core curriculum case illustration: placental abruption. ( 28439745 )
2017
4
Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review. ( 28329897 )
2017
5
Mortality and causes of death among women with a history of placental abruption. ( 28832915 )
2017
6
Seat Belt Sign as a Predictor of Placental Abruption. ( 29183513 )
2017
7
Circadian Variation in the Onset of Placental Abruption. ( 28163931 )
2017
8
Clinical significance of primary symptoms in women with placental abruption. ( 28629246 )
2017
9
Increased risk of placental abruption after solomon laser treatment of twin-twin transfusion syndrome. ( 28487021 )
2017
10
First-Trimester and Second-Trimester Maternal Serum Biomarkers as Predictors of Placental Abruption. ( 28178056 )
2017
11
Correction to: Clinical significance of primary symptoms in women with placental abruption. ( 28756712 )
2017
12
Placental Abruption With Delayed Fetal Compromise in Maternal Acetaminophen Toxicity. ( 29189681 )
2017
13
Placental abruption in parents who were born small: registry-based cohort study. ( 28755463 )
2017
14
Placental abruption leading to hysterectomy. ( 29233830 )
2017
15
Vaginal delivery after placental abruption with intrauterine fetal death: A 20-year single-center experience. ( 28370793 )
2017
16
Neonatal Outcomes Associated with Placental Abruption. ( 28595292 )
2017
17
Placental Abruption With Delayed Fetal Compromise in Maternal Acetaminophen Toxicity. ( 28594770 )
2017
18
Cardiovascular Disease in Relation to Placental Abruption: AA Population-Based Cohort Study from Denmark. ( 28221677 )
2017
19
Developmental outcomes in children following placental abruption: novel methods to disentangle causes and mediators. ( 27132247 )
2016
20
Poster 46 Multiple Amputations Including Bilateral Transtibial Amputations in a 29-Year-Old Female After Suffering Placental Abruption, GBS Septicemia and DIC: AA Case Report. ( 27672813 )
2016
21
Diagnosis of placental abruption: a legal issue for physicians. ( 26866304 )
2016
22
Placental abruption possibly due to parvovirus B19 infection. ( 27547655 )
2016
23
Does apoptotic activity have a role in the development of the placental abruption? ( 27893299 )
2016
24
Placental genetic variations in circadian clock-related genes increase the risk of placental abruption. ( 27186326 )
2016
25
Air Pollutant Exposure within a Few Days of Delivery and Placental Abruption in Japan. ( 27922526 )
2016
26
Maternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Study. ( 27300725 )
2016
27
The role of mean platelet volume and platelet distribution width in the prediction of placental abruption. ( 27184035 )
2016
28
The Necessity of Awareness of Early Symptoms of Placental Abruption Among Pregnant Japanese Women. ( 27540442 )
2016
29
ASSOCIATION BETWEEN PLACENTAL ABRUPTION AND CAESAREAN SECTION AMONG PATIENTS AT KHYBER TEACHING HOSPITAL PESHAWAR. ( 27323587 )
2016
30
Pre-delivery fibrinogen predicts adverse maternal or neonatal outcomes in patients with placental abruption. ( 27075198 )
2016
31
A Rare Cause of Placental Abruption: Uterine Torsion. ( 26894131 )
2016
32
Fetal cerebral and umbilical Doppler in pregnancies complicated by late-onset placental abruption. ( 27484964 )
2016
33
Placental Abruption Revealed by Hemoperitoneum: A Case Report. ( 27994944 )
2016
34
Circulating Levels of Pregnancy-Associated, Placenta-Specific microRNAs in Pregnant Women With Placental Abruption. ( 27297699 )
2016
35
Ambient PM2.5 Aluminum and Elemental Carbon and Placental Abruption Morbidity. ( 28002353 )
2016
36
Trauma in pregnant women: assessing detection of post-traumatic placental abruption on contrast-enhanced CT versus ultrasound. ( 27853848 )
2016
37
Use of uterine artery embolization toA prevent peripartum hemorrhage of placental abruption with fetal demise & severe DIC. ( 27589544 )
2016
38
Neurodevelopmental outcomes in children in relation to placental abruption. ( 27102365 )
2016
39
Randomized, Double-Blinded Trial of Magnesium Sulfate Tocolysis versus Intravenous Normal Saline for Preterm Nonsevere Placental Abruption. ( 26871905 )
2016
40
Rapid-Sequence Intubation in the Left-Lateral Tilt Position in a Pregnant Woman with Premature Placental Abruption Utilizing a Videolaryngoscope. ( 26199794 )
2015
41
Coagulopathy and placental abruption: changing management with ROTEM-guided fibrinogen concentrate therapy. ( 25659517 )
2015
42
[231-POS]: Recurrent abruption in hypertensive pregnancy; a case report and historical control study for the mode of delivery after fetal death by placental abruption. ( 25787581 )
2015
43
Circadian clock-related genetic risk scores and risk of placental abruption. ( 26515929 )
2015
44
Placental abruption: Are we going to lose them both? ( 25871760 )
2015
45
[186-POS]: Role of coagulation factors in placental abruption in the Chinese population. ( 25787537 )
2015
46
Association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with preterm delivery and placental abruption: a systematic review and meta-analysis. ( 26439908 )
2015
47
Placental telomere length and risk of placental abruption. ( 26611732 )
2015
48
Coagulopathy and placental abruption: changing management with ROTEM-guided fibrinogen concentrate therapy. ( 25840856 )
2015
49
Re: Prenatal vitamin C and E supplementation in smokers is associated with reduced placental abruption and preterm birth: a secondary analysis. ( 25892472 )
2015
50
Change in paternity, risk of placental abruption and confounding by birth interval: a population-based prospective cohort study in Norway, 1967-2009. ( 25670732 )
2015

Variations for Placental Abruption

Expression for Placental Abruption

Search GEO for disease gene expression data for Placental Abruption.

Pathways for Placental Abruption

GO Terms for Placental Abruption

Cellular components related to Placental Abruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 AGT APOH F2 F5 FLT1 PGF
2 blood microparticle GO:0072562 9.33 AGT F2 SERPINC1
3 extracellular space GO:0005615 9.28 AGT APOH ENG F2 F5 FLT1

Biological processes related to Placental Abruption according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 AGT F2 FLT1 PGF
2 positive regulation of angiogenesis GO:0045766 9.7 ENG FLT1 PGF
3 female pregnancy GO:0007565 9.61 AGT PGF THBD
4 positive regulation of reactive oxygen species metabolic process GO:2000379 9.57 AGT F2
5 sprouting angiogenesis GO:0002040 9.56 ENG PGF
6 blood coagulation GO:0007596 9.56 F2 F5 SERPINC1 THBD
7 positive regulation of collagen biosynthetic process GO:0032967 9.55 ENG F2
8 folic acid metabolic process GO:0046655 9.54 MTHFD1 MTHFR
9 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.54 AGT F2 FLT1
10 blood coagulation, intrinsic pathway GO:0007597 9.51 APOH F2
11 negative regulation of blood coagulation GO:0030195 9.49 APOH THBD
12 positive regulation of blood coagulation GO:0030194 9.48 APOH F2
13 tetrahydrofolate interconversion GO:0035999 9.46 MTHFD1 MTHFR
14 negative regulation of platelet activation GO:0010544 9.4 F2 THBD
15 regulation of blood coagulation GO:0030193 9.33 APOH F2 SERPINC1
16 methionine metabolic process GO:0006555 9.32 MTHFD1 MTHFR
17 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 THBD
18 hemostasis GO:0007599 8.92 F2 F5 SERPINC1 THBD

Molecular functions related to Placental Abruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 AGT F2 PGF
2 heparin binding GO:0008201 8.92 APOH F2 PGF SERPINC1

Sources for Placental Abruption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....