MCID: PLC007
MIFTS: 50

Placental Abruption malady

Fetal diseases category
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Summaries for Placental Abruption

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

MalaCards: Placental Abruption, also known as abruptio placentae, is related to eclampsia and hypertension. An important gene associated with Placental Abruption is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Cell surface interactions at the vascular wall. The compounds perindopril and 8-isoprostane have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and heart, and related mouse phenotypes are hematopoietic system and cardiovascular system.

Wikipedia:65 Placental abruption (also known as abruptio placentae) is a complication of pregnancy, wherein the... more...

Aliases & Classifications for Placental Abruption

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8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

placental abruption 8 9 47 10
abruptio placentae 8 47 45 62
abruptio placentae, susceptibility to 9


External Ids:

Disease Ontology8 DOID:9667
MeSH35 D000033
ICD9CM27 640.0

Related Diseases for Placental Abruption

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Placental Abruption:



Diseases related to placental abruption

Symptoms for Placental Abruption

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Drugs & Therapeutics for Placental Abruption

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Placental Abruption

Search NIH Clinical Center for Placental Abruption

Genetic Tests for Placental Abruption

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Anatomical Context for Placental Abruption

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33MalaCards
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MalaCards organs/tissues related to Placental Abruption:

33
Placenta, Uterus, Heart, Testes, Endothelial, Brain, Spleen, Retina

Animal Models for Placental Abruption or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Placental Abruption:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.4NOS3, PROC, EBAG9, THBD
2MP:00053857.8THBD, PROC, F5, NOS3
3MP:00053707.7NOS3, F5, BHMT, PROC, THBD
4MP:00053787.6THBD, PROC, BHMT, F5, NOS3
5MP:00053767.5THBD, PROC, BHMT, F5, NOS3

Publications for Placental Abruption

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52PubMed
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Articles related to Placental Abruption:

(show top 50)    (show all 267)
idTitleAuthorsYear
1
Risk factors of placental abruption. (24174950)
2013
2
Decreasing perinatal mortality in placental abruption. (23072758)
2013
3
Placenta praevia, placental abruption and amphetamine use in pregnancy: a case study. (23266230)
2013
4
MR imaging in the evaluation of placental abruption: correlation with sonographic findings. (21330568)
2011
5
Two cases of angular pregnancy complicated by preterm labor and placental abruption at mid-pregnancy. (21450029)
2011
6
Is the perinatal outcome of placental abruption modified by clinical presentation? (21490793)
2011
7
Hysterotomy and evacuation of a deciduate placental hematoma following placental abruption. (20624620)
2010
8
Self-reported smoking habits and serum cotinine levels in women with placental abruption. (21050148)
2010
9
Maternal deaths in Finland: focus on placental abruption. (19707898)
2009
10
Pre-eclampsia, placental abruption and increased risk of atopic sensitization in male adolescent offspring. (19811463)
2009
11
The increase in metallothionein and ectopic decidual immunoreactivity with respect to the progression of labor at term and the lack of analogical changes in placental abruption. (18782281)
2008
12
Low birthweight in relation to placental abruption and maternal thrombophilia status. (18191809)
2008
13
Folic acid and multivitamin supplement use and risk of placental abruption: a population-based registry study. (18187445)
2008
14
Failure of second-trimester measurement of soluble endoglin and other angiogenic factors to predict placental abruption. (17960788)
2007
15
Risk and risk estimation of placental abruption. (16202500)
2006
16
Uterine torsion with placental abruption. (16483985)
2006
17
Placental abruption in term and preterm gestations: evidence for heterogeneity in clinical pathways. (16582113)
2006
18
Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in Finnish women. (16260885)
2005
19
Anti-fetal immune response mechanisms may be involved in the pathogenesis of placental abruption. (14962795)
2004
20
Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption. (15582499)
2004
21
Could placental abruption be an antiphospholipid antibody related disorder? (15144143)
2004
22
Sucessful pregnancy outcome following three severe placental abruptions and intrauterine fetal death in the patient--heterozygous carrier of R506Q mutation of factor V (Leiden)]. (15518286)
2004
23
Interventions for treating placental abruption. (12535464)
2003
24
Placental abruption is associated with decreased maternal plasma levels of soluble HLA-G. (12959223)
2003
25
Hysterotomy for maternal life-threatening hemorrhage secondary to placental abruption at 24 weeks gestation. (12918463)
2003
26
The profile and complications of women with placental abruption and intrauterine death. (12929885)
2003
27
Clinical utility of sonography in the diagnosis and treatment of placental abruption. (12164566)
2002
28
Thrombin-enhanced matrix metalloproteinase-1 expression: a mechanism linking placental abruption with premature rupture of the membranes. (12380602)
2002
29
Placental abruption. (11997676)
2002
30
The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption. (11354626)
2001
31
Sonolucency of a fresh hematoma in a case of marginal placental abruption. (11451559)
2001
32
Placental abruption and adverse perinatal outcomes. (10553791)
1999
33
Is fetal gender significant in the perinatal outcome of pregnancies complicated by placental abruption? (15512413)
1999
34
Thrombomodulin: a new marker for placental abruption. (9974370)
1999
35
Preterm labor, placental abruption, and premature rupture of membranes in relation to maternal violence or verbal abuse. (10338059)
1999
36
The effect on the likelihood of further pregnancy of placental abruption and the rate of its recurrence. (9800939)
1998
37
Plasma fibrin D-dimer in pregnancies complicated by partial placental abruption. (9323905)
1997
38
Maternal serum alpha-fetoprotein in placental abruption associated with preterm labor. (9127154)
1997
39
Influence of hypertensive disorders and cigarette smoking on placental abruption and uterine bleeding during pregnancy. (9166200)
1997
40
Placental abruption following placement of disposable intrauterine pressure transducer system. (8442792)
1993
41
Conservative management of placental abruption complicated by severe clotting disorders. (1426497)
1992
42
Feto-pelvic disproportion of mimicking placental abruption. (2102210)
1990
43
Pulmonary thromboembolism complicating recurrent placental abruption at 29 weeks' gestation. (2400355)
1990
44
Fetal and uteroplacental flow velocity waveforms in the expectant management of placental abruption. (2227614)
1990
45
Uteroplacental and umbilical artery blood velocity waveforms in placental abruption assessed by Doppler ultrasound. (2930753)
1989
46
Placental abruption associated with cocaine abuse. (3285653)
1988
47
Placental abruption and subchorionic hemorrhage in the first half of pregnancy: US appearance and clinical outcome. (3520643)
1986
48
Case report: ruptured spleen, placental abruption and toxemia of pregnancy. Simultaneous complications of pregnancy. (927413)
1977
49
Urinary estriol excretion before severe placental abruption. (5473999)
1970
50
Pathogenesis of hypofibrinogenemia in placental abruption. (13674508)
1959

Variations for Placental Abruption

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Expression for genes affiliated with Placental Abruption

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Placental Abruption

Search GEO for disease gene expression data for Placental Abruption.

Pathways for genes affiliated with Placental Abruption

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 54R&D Systems, 30KEGG
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Compounds for genes affiliated with Placental Abruption

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Placental Abruption according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1perindopril45 51 1111.9NOS3, THBD
28-isoprostane459.9NOS3, THBD
3fluvastatin45 51 29 1112.8THBD, NOS3
4pravastatin45 51 29 24 1113.7NOS3, THBD
5azathioprine45 3 51 1112.7THBD, NOS3
6cystathionine459.6F5, BHMT
7hirugen459.6F5, THBD
8ximelagatran45 1110.6THBD, F5
9ancrod459.6THBD, F5
10heparinoids459.6F5, THBD
11fondaparinux459.5THBD, F5
12bivalirudin45 1110.5THBD, F5
13argatroban45 1110.5F5, THBD
14cacl2459.5F5, THBD
15benzamidine45 1110.5F5, THBD
16desmopressin45 61 29 1112.5THBD, F5
17cardiolipin45 1110.5F5, THBD
18vitamin b12459.5F5, BHMT
19hirudin459.5F5, THBD
20mycophenolate mofetil45 51 1111.5THBD, F5
21dermatan sulfate459.4F5, THBD
22kininogen459.4F5, THBD
23tunicamycin45 6110.4F5, THBD
24pge1459.4F5, THBD
25aprotinin45 1110.4THBD, F5
26polyethylene glycol459.3F5, THBD
27sodium dodecylsulfate459.3NOS3, F5
28vitamin-e459.3F5, THBD
29raloxifene45 51 29 1112.2THBD, F5, NOS3
30atorvastatin45 51 29 24 1113.2NOS3, F5, THBD
31citrate459.1NOS3, F5, THBD
32simvastatin45 51 61 29 24 1114.1NOS3, F5, THBD
33cyclophosphamide45 51 1111.1NOS3, F5, THBD
34prostacyclin459.1NOS3, F5, THBD
35vitamin b6459.1F5, BHMT, THBD
36aspirin45 51 29 2412.1THBD, F5, NOS3
37ascorbic acid45 2410.1THBD, F5, NOS3
38gamma-carboxyglutamic acid459.0F5, PROC, THBD
39warfarin45 51 24 1111.9F5, PROC, THBD
40fibrinogen458.9F5, PROC, THBD
41phospholipid458.9F5, PROC, THBD
42heparin45 29 24 1111.8F5, PROC, THBD
43vegf458.7NOS3, F5, THBD
44glutamate458.7NOS3, F5, THBD
45homocysteine45 249.7NOS3, F5, BHMT, THBD
46folate458.7THBD, BHMT, F5, NOS3
47arginine458.6THBD, F5, NOS3
48estrogen458.6THBD, EBAG9, F5, NOS3
49nitric oxide45 24 1110.4NOS3, F5, THBD
50serine458.1THBD, PROC, BHMT, F5, NOS3

GO Terms for genes affiliated with Placental Abruption

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16Gene Ontology
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Cellular components related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.6NOS3, F5, PROC, EBAG9, THBD

Biological processes related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:0105449.4THBD, NOS3
2leukocyte migrationGO:0509009.3PROC, THBD
3negative regulation of blood coagulationGO:0301959.0PROC, THBD
4blood coagulationGO:0075968.1NOS3, F5, PROC, THBD

Molecular functions related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.0F5, PROC

Products for genes affiliated with Placental Abruption

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Sources for Placental Abruption

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet