MCID: PLC007
MIFTS: 50

Placental Abruption malady

Fetal diseases category

Summaries for Placental Abruption

About this section
Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Disease Ontology:9 A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

MalaCards: Placental Abruption, also known as abruptio placentae, is related to eclampsia and hypertension. An important gene associated with Placental Abruption is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Cell surface interactions at the vascular wall. The compounds perindopril and 8-isoprostane have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and heart, and related mouse phenotypes are hematopoietic system and cardiovascular system.

Wikipedia:66 Placental abruption (also known as abruptio placentae) is a complication of pregnancy, wherein the... more...

Aliases & Classifications for Placental Abruption

About this section
Sources:
9Disease Ontology, 10diseasecard, 48OMIM, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

placental abruption 9 10 48 11
abruptio placentae 9 48 46 63
abruptio placentae, susceptibility to 10


External Ids:

Disease Ontology9 DOID:9667
MeSH36 D000033
ICD9CM28 640.0

Related Diseases for Placental Abruption

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Placental Abruption:



Diseases related to placental abruption

Symptoms for Placental Abruption

About this section

Drugs & Therapeutics for Placental Abruption

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Placental Abruption

Drug clinical trials:

Search ClinicalTrials for Placental Abruption

Search NIH Clinical Center for Placental Abruption

Search CenterWatch for Placental Abruption

Genetic Tests for Placental Abruption

About this section

Anatomical Context for Placental Abruption

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Placental Abruption:

34
Placenta, Uterus, Heart, Testes, Endothelial, Brain, Spleen, Retina

Animal Models for Placental Abruption or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Placental Abruption:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.4NOS3, PROC, EBAG9, THBD
2MP:00053857.8THBD, PROC, F5, NOS3
3MP:00053707.7NOS3, F5, BHMT, PROC, THBD
4MP:00053787.6THBD, PROC, BHMT, F5, NOS3
5MP:00053767.5THBD, PROC, BHMT, F5, NOS3

Publications for Placental Abruption

About this section
Sources:
53PubMed
See all sources

Articles related to Placental Abruption:

(show top 50)    (show all 267)
idTitleAuthorsYear
1
Risk factors of placental abruption. (24174950)
2013
2
Decreasing perinatal mortality in placental abruption. (23072758)
2013
3
Placenta praevia, placental abruption and amphetamine use in pregnancy: a case study. (23266230)
2013
4
MR imaging in the evaluation of placental abruption: correlation with sonographic findings. (21330568)
2011
5
Two cases of angular pregnancy complicated by preterm labor and placental abruption at mid-pregnancy. (21450029)
2011
6
Is the perinatal outcome of placental abruption modified by clinical presentation? (21490793)
2011
7
Hysterotomy and evacuation of a deciduate placental hematoma following placental abruption. (20624620)
2010
8
Self-reported smoking habits and serum cotinine levels in women with placental abruption. (21050148)
2010
9
Maternal deaths in Finland: focus on placental abruption. (19707898)
2009
10
Pre-eclampsia, placental abruption and increased risk of atopic sensitization in male adolescent offspring. (19811463)
2009
11
The increase in metallothionein and ectopic decidual immunoreactivity with respect to the progression of labor at term and the lack of analogical changes in placental abruption. (18782281)
2008
12
Low birthweight in relation to placental abruption and maternal thrombophilia status. (18191809)
2008
13
Folic acid and multivitamin supplement use and risk of placental abruption: a population-based registry study. (18187445)
2008
14
Failure of second-trimester measurement of soluble endoglin and other angiogenic factors to predict placental abruption. (17960788)
2007
15
Risk and risk estimation of placental abruption. (16202500)
2006
16
Uterine torsion with placental abruption. (16483985)
2006
17
Placental abruption in term and preterm gestations: evidence for heterogeneity in clinical pathways. (16582113)
2006
18
Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in Finnish women. (16260885)
2005
19
Anti-fetal immune response mechanisms may be involved in the pathogenesis of placental abruption. (14962795)
2004
20
Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption. (15582499)
2004
21
Could placental abruption be an antiphospholipid antibody related disorder? (15144143)
2004
22
Sucessful pregnancy outcome following three severe placental abruptions and intrauterine fetal death in the patient--heterozygous carrier of R506Q mutation of factor V (Leiden)]. (15518286)
2004
23
Interventions for treating placental abruption. (12535464)
2003
24
Placental abruption is associated with decreased maternal plasma levels of soluble HLA-G. (12959223)
2003
25
Hysterotomy for maternal life-threatening hemorrhage secondary to placental abruption at 24 weeks gestation. (12918463)
2003
26
The profile and complications of women with placental abruption and intrauterine death. (12929885)
2003
27
Clinical utility of sonography in the diagnosis and treatment of placental abruption. (12164566)
2002
28
Thrombin-enhanced matrix metalloproteinase-1 expression: a mechanism linking placental abruption with premature rupture of the membranes. (12380602)
2002
29
Placental abruption. (11997676)
2002
30
The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption. (11354626)
2001
31
Sonolucency of a fresh hematoma in a case of marginal placental abruption. (11451559)
2001
32
Placental abruption and adverse perinatal outcomes. (10553791)
1999
33
Is fetal gender significant in the perinatal outcome of pregnancies complicated by placental abruption? (15512413)
1999
34
Thrombomodulin: a new marker for placental abruption. (9974370)
1999
35
Preterm labor, placental abruption, and premature rupture of membranes in relation to maternal violence or verbal abuse. (10338059)
1999
36
The effect on the likelihood of further pregnancy of placental abruption and the rate of its recurrence. (9800939)
1998
37
Plasma fibrin D-dimer in pregnancies complicated by partial placental abruption. (9323905)
1997
38
Maternal serum alpha-fetoprotein in placental abruption associated with preterm labor. (9127154)
1997
39
Influence of hypertensive disorders and cigarette smoking on placental abruption and uterine bleeding during pregnancy. (9166200)
1997
40
Placental abruption following placement of disposable intrauterine pressure transducer system. (8442792)
1993
41
Conservative management of placental abruption complicated by severe clotting disorders. (1426497)
1992
42
Feto-pelvic disproportion of mimicking placental abruption. (2102210)
1990
43
Pulmonary thromboembolism complicating recurrent placental abruption at 29 weeks' gestation. (2400355)
1990
44
Fetal and uteroplacental flow velocity waveforms in the expectant management of placental abruption. (2227614)
1990
45
Uteroplacental and umbilical artery blood velocity waveforms in placental abruption assessed by Doppler ultrasound. (2930753)
1989
46
Placental abruption associated with cocaine abuse. (3285653)
1988
47
Placental abruption and subchorionic hemorrhage in the first half of pregnancy: US appearance and clinical outcome. (3520643)
1986
48
Case report: ruptured spleen, placental abruption and toxemia of pregnancy. Simultaneous complications of pregnancy. (927413)
1977
49
Urinary estriol excretion before severe placental abruption. (5473999)
1970
50
Pathogenesis of hypofibrinogenemia in placental abruption. (13674508)
1959

Variations for Placental Abruption

About this section

Expression for genes affiliated with Placental Abruption

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Placental Abruption

Search GEO for disease gene expression data for Placental Abruption.

Pathways for genes affiliated with Placental Abruption

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 55R&D Systems, 31KEGG
See all sources

Compounds for genes affiliated with Placental Abruption

About this section
Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 3BitterDB, 62Tocris Bioscience
See all sources

Compounds related to Placental Abruption according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1perindopril46 52 1211.9NOS3, THBD
28-isoprostane469.9NOS3, THBD
3fluvastatin46 52 30 1212.8THBD, NOS3
4pravastatin46 52 30 25 1213.7NOS3, THBD
5azathioprine46 3 52 1212.7THBD, NOS3
6cystathionine469.6F5, BHMT
7hirugen469.6F5, THBD
8ximelagatran46 1210.6THBD, F5
9ancrod469.6THBD, F5
10heparinoids469.6F5, THBD
11fondaparinux469.5THBD, F5
12bivalirudin46 1210.5THBD, F5
13argatroban46 1210.5F5, THBD
14cacl2469.5F5, THBD
15benzamidine46 1210.5F5, THBD
16desmopressin46 62 30 1212.5THBD, F5
17cardiolipin46 1210.5F5, THBD
18vitamin b12469.5F5, BHMT
19hirudin469.5F5, THBD
20mycophenolate mofetil46 52 1211.5THBD, F5
21dermatan sulfate469.4F5, THBD
22kininogen469.4F5, THBD
23tunicamycin46 6210.4F5, THBD
24pge1469.4F5, THBD
25aprotinin46 1210.4THBD, F5
26polyethylene glycol469.3F5, THBD
27sodium dodecylsulfate469.3NOS3, F5
28vitamin-e469.3F5, THBD
29raloxifene46 52 30 1212.2THBD, F5, NOS3
30atorvastatin46 52 30 25 1213.2NOS3, F5, THBD
31citrate469.1NOS3, F5, THBD
32simvastatin46 52 62 30 25 1214.1NOS3, F5, THBD
33cyclophosphamide46 52 1211.1NOS3, F5, THBD
34prostacyclin469.1NOS3, F5, THBD
35vitamin b6469.1F5, BHMT, THBD
36aspirin46 52 30 2512.1THBD, F5, NOS3
37ascorbic acid46 2510.1THBD, F5, NOS3
38gamma-carboxyglutamic acid469.0F5, PROC, THBD
39warfarin46 52 25 1211.9F5, PROC, THBD
40fibrinogen468.9F5, PROC, THBD
41phospholipid468.9F5, PROC, THBD
42heparin46 30 25 1211.8F5, PROC, THBD
43vegf468.7NOS3, F5, THBD
44glutamate468.7NOS3, F5, THBD
45homocysteine46 259.7NOS3, F5, BHMT, THBD
46folate468.7THBD, BHMT, F5, NOS3
47arginine468.6THBD, F5, NOS3
48estrogen468.6THBD, EBAG9, F5, NOS3
49nitric oxide46 25 1210.4NOS3, F5, THBD
50serine468.1THBD, PROC, BHMT, F5, NOS3

GO Terms for genes affiliated with Placental Abruption

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.6NOS3, F5, PROC, EBAG9, THBD

Biological processes related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:0105449.4THBD, NOS3
2leukocyte migrationGO:0509009.3PROC, THBD
3negative regulation of blood coagulationGO:0301959.0PROC, THBD
4blood coagulationGO:0075968.1NOS3, F5, PROC, THBD

Molecular functions related to Placental Abruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.0F5, PROC

Products for genes affiliated with Placental Abruption

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Placental Abruption

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet