MCID: PLC007
MIFTS: 46

Placental Abruption

Categories: Fetal diseases

Aliases & Classifications for Placental Abruption

MalaCards integrated aliases for Placental Abruption:

Name: Placental Abruption 12 14
Abruptio Placentae 12 52 69
Abortion, Threatened 42
Abruptio Placenta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9667
ICD10 33 O20.0
ICD9CM 35 640.0 640.03
MeSH 42 D000033
NCIt 47 C112857
UMLS 69 C0000821

Summaries for Placental Abruption

Disease Ontology : 12 A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

MalaCards based summary : Placental Abruption, also known as abruptio placentae, is related to kidney cortex necrosis and multicentric osteolysis nephropathy. An important gene associated with Placental Abruption is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Methyldopa and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Placental abruption, also known as abruptio placentae, is a complication of pregnancy, wherein the... more...

Related Diseases for Placental Abruption

Diseases related to Placental Abruption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
id Related Disease Score Top Affiliating Genes
1 kidney cortex necrosis 11.0
2 multicentric osteolysis nephropathy 10.7 F5 MTHFR
3 coronary sinus stenosis 10.7 F5 MTHFR
4 amelogenesis imperfecta hypomaturation type 10.7 F5 MTHFR
5 variably protease-sensitive prionopathy 10.7 F2 F5
6 porphyria 10.7 F2 MTHFR
7 mcgillivray syndrome 10.7 APOH F5
8 bile duct cystadenoma 10.7 F2 F5
9 accessory deep peroneal nerve 10.7 APOH F5
10 facioscapulohumeral muscular dystrophy 1 10.6 F2 F5
11 landau-kleffner syndrome 10.6 APOH F2
12 factor v deficiency 10.6 F2 F5
13 prostatitis 10.6 APOH F2
14 inherited blood coagulation disease 10.5 F2 F5
15 irak4 deficiency 10.5 F2 F5
16 stoll alembik finck syndrome 10.5 F5 SERPINC1
17 pyridoxine deficiency anemia 10.5 F2 SERPINC1
18 schizencephaly 10.5 F5 MTHFR
19 fragile x syndrome type 2 10.5 F2 SERPINC1
20 primary pigmented nodular adrenocortical disease 10.5 F2 F5 MTHFR
21 homologous wasting disease 10.4 F2 F5 MTHFR
22 hepatocellular adenoma 10.4 F2 F5 MTHFR
23 myiasis 10.4 F2 SERPINC1
24 egg allergy 10.4 F2 SERPINC1
25 thrombomodulin anomalies, familial 10.4 F2 F5 MTHFR
26 rectum neuroendocrine neoplasm 10.4 F2 SERPINC1
27 syndactyly, mesoaxial synostotic, with phalangeal reduction 10.4 F2 SERPINC1
28 midline cystocele 10.4 F2 SERPINC1
29 littre gland carcinoma 10.4 F2 SERPINC1
30 charcot-marie-tooth disease 10.4 F2 F5 MTHFR
31 pilomyxoid astrocytoma 10.4 F2 SERPINC1
32 acute lymphocytic leukemia 10.4 F2 F5
33 inferolateral myocardial infarct 10.4 F2 SERPINC1
34 pregnancy loss, recurrent 1 10.4 APOH F5 MTHFR
35 cavernous lymphangioma 10.4 APOH F5 MTHFR
36 46,xy ovotesticular disorder of sex development 10.4 APOH F2 F5
37 malignant type ab thymoma 10.4 F2 F5 MTHFR
38 angelucci's syndrome 10.4 F2 SERPINC1
39 moderately severe hemophilia b 10.4 F2 F5
40 lethal congenital contracture syndrome 10.4 F2 SERPINC1
41 elejalde disease 10.4 APOH F2 MTHFR
42 squamous cell papilloma 10.4 AGT F2
43 lujo hemorrhagic fever 10.3 F2 SERPINC1
44 essential thrombocythemia 10.3 F2 SERPINC1
45 childhood brain stem glioma 10.3 F2 SERPINC1
46 hepadnavirus infection 10.3 F2 SERPINC1
47 psychologic dyspareunia 10.3 F2 THBD
48 acitretin/etretinate embryopathy 10.3 FLT1 PGF
49 idiopathic progressive polyneuropathy 10.3 FLT1 PGF
50 coloboma of superior eyelid 10.3 FLT1 PGF

Graphical network of the top 20 diseases related to Placental Abruption:



Diseases related to Placental Abruption

Symptoms & Phenotypes for Placental Abruption

MGI Mouse Phenotypes related to Placental Abruption:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 F5 FLT1 PGF SERPINC1 THBD AGT
2 homeostasis/metabolism MP:0005376 10.02 AGT APOH ENG F2 F5 FLT1
3 growth/size/body region MP:0005378 9.97 AGT ENG F2 F5 FLT1 MTHFR
4 embryo MP:0005380 9.95 ENG F2 F5 FLT1 PGF SERPINC1
5 mortality/aging MP:0010768 9.81 THBD AGT APOH ENG F2 F5
6 integument MP:0010771 9.73 ENG F2 F5 MTHFR PGF THBD
7 nervous system MP:0003631 9.56 AGT ENG F2 F5 FLT1 MTHFR
8 reproductive system MP:0005389 9.1 AGT F2 FLT1 MTHFR SERPINC1 THBD

Drugs & Therapeutics for Placental Abruption

Drugs for Placental Abruption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 114)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4 555-30-6 38853
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 1 50-56-6 439302 53477758
4
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 3 7487-88-9 24083
5 Antihypertensive Agents Phase 4
6 Analgesics Phase 4,Phase 3,Phase 2
7 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
8 Tocolytic Agents Phase 4,Phase 3,Phase 2
9 Anti-Bacterial Agents Phase 4
10 Anti-Infective Agents Phase 4,Phase 3
11 Clindamycin palmitate Phase 4
12 Clindamycin phosphate Phase 4
13 Oxytocics Phase 4,Phase 3,Phase 1
14 Anesthetics Phase 4,Phase 3,Phase 1
15 Anti-Arrhythmia Agents Phase 4,Phase 3
16 Anticonvulsants Phase 4,Phase 3
17 calcium channel blockers Phase 4,Phase 3
18 Calcium, Dietary Phase 4,Phase 3,Phase 2
19 Central Nervous System Depressants Phase 4,Phase 3,Phase 1
20
Aspirin Approved, Vet_approved Phase 3,Phase 2 50-78-2 2244
21
Dalteparin Approved Phase 3 9005-49-6
22
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
23
Tranexamic Acid Approved Phase 3 1197-18-8 5526
24
Hydroxocobalamin Approved Phase 3 13422-51-0 11953898 5460373 44475014
25
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
26
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
27
Salicylic acid Approved, Vet_approved Phase 3 69-72-7 338
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
29
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
30
Biotin Approved, Nutraceutical Phase 3 58-85-5 171548
31
Cyanocobalamin Approved, Nutraceutical Phase 3 68-19-9 44176380
32
Pyridoxal Approved, Nutraceutical Phase 3 66-72-8 1050
33
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 3 65-23-6 1054
34
Riboflavin Approved, Nutraceutical, Vet_approved Phase 3 83-88-5 493570
35
Thiamine Approved, Nutraceutical, Vet_approved Phase 3 59-43-8 1130
36 Tocopherol Approved, Nutraceutical Phase 3
37
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
38
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
39 Hematinics Phase 3
40 Micronutrients Phase 3
41 Trace Elements Phase 3
42 Vitamin B Complex Phase 3
43 Vitamins Phase 3
44 Analgesics, Non-Narcotic Phase 3,Phase 2
45 Anti-Inflammatory Agents Phase 3,Phase 2
46 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
47 Antipyretics Phase 3,Phase 2
48 Antirheumatic Agents Phase 3,Phase 2
49 Cyclooxygenase Inhibitors Phase 3,Phase 2
50 Fibrinolytic Agents Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 55)

id Name Status NCT ID Phase Drugs
1 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4 methildopa;placebo
2 Induction of Labor With a Foley Balloon Catheter: Inflation With 30ml Compared to 60ml Completed NCT00451308 Phase 4
3 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
4 Foley Bulb With Low Dose Pitocin Versus Foley Bulb With a Standard Incremental Infusion Protocol for the Induction of Labor Completed NCT02150954 Phase 4 pitocin
5 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
6 Folic Acid Dosage and Malformations Reduction Unknown status NCT01244347 Phase 3 folic acid;folic acid
7 Low Dose Aspirin for the Prevention of Preeclampsia Unknown status NCT01890005 Phase 3 Aspirin;Placebo
8 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
9 Syringe or Continuous Amnioreduction for Symptomatic Polyhydramnios. A Prospective Randomized Study. Completed NCT00236340 Phase 3
10 Can we Use Intravenous Injection of Tranexamic Acid in Routine Practice With Active Management of the Third Stage of Labor? Completed NCT01338454 Phase 3 transamin
11 Intraumbilical Vein Injection of Oxytocin in Routine Practice for Active Management of the Third Stage of Labor Completed NCT01094028 Phase 3 Oxytocin
12 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
13 Low Molecular Weight Heparin and/or Aspirin in Prevention of Habitual Abortion Completed NCT00959621 Phase 3 Aspirin;Klexane;Klexane and ASA
14 TIPPS: Thrombophilia in Pregnancy Prophylaxis Study Completed NCT00967382 Phase 3 dalteparin sodium
15 Controlled Cord Traction During Third Stage of Labor Completed NCT00781066 Phase 3
16 Effectiveness of Dalteparin Therapy as Intervention in Recurrent Pregnancy Loss Completed NCT00400387 Phase 3 Fragmin P Forte (dalteparin sodium)
17 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
18 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3 Folic Acid 4 mg;Placebo
19 RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil Completed NCT00097110 Phase 3 Vitamin C and E
20 Low Dose Aspirin in the Prevention of Preeclampsia in China Recruiting NCT02797249 Phase 3 Aspirin
21 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
22 Utility of Tocolytic Therapy for Maintenance Tocolysis in the Management of Threatened Preterm Delivery Withdrawn NCT01796522 Phase 3 progesterone 200 mg / day vaginally;nifedipine (60 mg / day orally)
23 Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM) Unknown status NCT00466128 Phase 2 indomethacin
24 Impact of the NO-donor Pentaerythrithyltetrantrate on Perinatal Outcome in High-risk Pregnancies Completed NCT01355822 Phase 1, Phase 2 PETN;Placebo control
25 Sildenafil Citrate for the Management of Asymmetrical Intrauterine Growth Restriction Not yet recruiting NCT02678221 Phase 2 Sildenafil citrate;Aspirin
26 A Comparison of B Type Natriuretic Peptide Levels and Hemodynamics Using the Nexfin Device in Healthy Pregnant and Preeclamptic Women - A Pilot Study Unknown status NCT02527018 Phase 1
27 Prophylactic Use of Intraumbilical Vein Oxytocin Injection in The Management of Third Stage of Labor Recruiting NCT02680938 Phase 1 oxytocin;saline
28 Spinal Analgesia Versus No Analgesia: Study for External Cephalic Version Terminated NCT00119184 Phase 1
29 Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity Unknown status NCT00573118
30 Prediction of Preeclampsia & Other Obstetric Complications by Serum Homocysteine & Doppler Unknown status NCT02541110
31 Relation Between Subclinical Hypothyroidism and Outcome of Pregnancy Unknown status NCT01335802
32 Haptoglobin and Diabetes Complications in Pregnancy Unknown status NCT01758016
33 Pre-Eclampsia Prediction By Doppler Screening Of Uterine Arteries And Angiogenic Factors In Second Trimester Of Pregnancy Unknown status NCT00725660
34 Comparison of Efficiency Between Practicing of Knee Chest Position and External Cephalic Version in Cases of Breech Presentation. Unknown status NCT02167841
35 The Prognosis of Early Pregnancy With Post Coital Bleeding Unknown status NCT02363569
36 İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? Unknown status NCT01906567
37 Prevention of Post-partum Haemorrhage Completed NCT01044082
38 Comparing Blood Loss During Caesarean Section Between Manual Separation of Placenta & Conservative Management Completed NCT02480556
39 Dose Adjusting Enoxaparin Thromboprophylaxis Dosage According to Anti-factor Xa Plasma Levels Improve Pregnancy Outcome Completed NCT01068795 enoxaparin
40 Early Prevention of Preeclampsia Study Completed NCT01547390 Aspirin;placebo
41 The Reduced Thyroid Function of the Premature Newborn: Relation With Molecular Changes in the Placenta and Maternal Thyroid Hormone Status and Neurodevelopmental Implications Completed NCT01466023
42 The Prognostic Value of PGF and sFlt1 Variations Induced by the First Low-molecular-weight-heparin Injections in Women With Obstetrical Antiphospholipids Antibody Syndrome Starting a New Pregnancy and Following Treatment in Accordance With International R Completed NCT02855047
43 Induction of Labor in Intrahepatic Cholestasis of Pregnancy Completed NCT01381939
44 Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women Completed NCT03154268
45 Doppler and Biological Second Trimester Placental Insufficiency Screening Completed NCT00465634
46 Induction Versus Expectant Management With Abnormal Maternal Biochemical Markers Recruiting NCT02754635
47 Omission of Controlled Cord Traction During Active Management of Third Stage of Labor Recruiting NCT02656108
48 Delayed Clamping and Milking the Umbilical Cord in Preterm Infants Recruiting NCT02092103
49 Magnesium Sulfate vs Placebo for Placental Abruption Active, not recruiting NCT00186069 Magnesium Sulfate
50 China Obstetrics Alliance Cohort Study Enrolling by invitation NCT03038555

Search NIH Clinical Center for Placental Abruption

Cochrane evidence based reviews: abortion, threatened

Genetic Tests for Placental Abruption

Anatomical Context for Placental Abruption

MalaCards organs/tissues related to Placental Abruption:

39
Placenta, Uterus, Heart, Testes, Brain, Liver, Thyroid

Publications for Placental Abruption

Articles related to Placental Abruption:

(show top 50) (show all 352)
id Title Authors Year
1
Placental Abruption With Delayed Fetal Compromise in Maternal Acetaminophen Toxicity. ( 28594770 )
2017
2
Vaginal delivery after placental abruption with intrauterine fetal death: A 20-year single-center experience. ( 28370793 )
2017
3
Neonatal Outcomes Associated with Placental Abruption. ( 28595292 )
2017
4
Clinical significance of primary symptoms in women with placental abruption. ( 28629246 )
2017
5
Correction to: Clinical significance of primary symptoms in women with placental abruption. ( 28756712 )
2017
6
Mortality and causes of death among women with a history of placental abruption. ( 28832915 )
2017
7
First-Trimester and Second-Trimester Maternal Serum Biomarkers as Predictors of Placental Abruption. ( 28178056 )
2017
8
Circadian Variation in the Onset of Placental Abruption. ( 28163931 )
2017
9
Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review. ( 28329897 )
2017
10
Increased risk of placental abruption after solomon laser treatment of twin-twin transfusion syndrome. ( 28487021 )
2017
11
Cardiovascular Disease in Relation to Placental Abruption: AA Population-Based Cohort Study from Denmark. ( 28221677 )
2017
12
Placental abruption in parents who were born small: registry-based cohort study. ( 28755463 )
2017
13
Core curriculum case illustration: placental abruption. ( 28439745 )
2017
14
Does apoptotic activity have a role in the development of the placental abruption? ( 27893299 )
2016
15
A Rare Cause of Placental Abruption: Uterine Torsion. ( 26894131 )
2016
16
The Necessity of Awareness of Early Symptoms of Placental Abruption Among Pregnant Japanese Women. ( 27540442 )
2016
17
Placental abruption possibly due to parvovirus B19 infection. ( 27547655 )
2016
18
Randomized, Double-Blinded Trial of Magnesium Sulfate Tocolysis versus Intravenous Normal Saline for Preterm Nonsevere Placental Abruption. ( 26871905 )
2016
19
Neurodevelopmental outcomes in children in relation to placental abruption. ( 27102365 )
2016
20
Pre-delivery fibrinogen predicts adverse maternal or neonatal outcomes in patients with placental abruption. ( 27075198 )
2016
21
Use of uterine artery embolization toA prevent peripartum hemorrhage of placental abruption with fetal demise & severe DIC. ( 27589544 )
2016
22
Ambient PM2.5 Aluminum and Elemental Carbon and Placental Abruption Morbidity. ( 28002353 )
2016
23
Maternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Study. ( 27300725 )
2016
24
Diagnosis of placental abruption: a legal issue for physicians. ( 26866304 )
2016
25
Air Pollutant Exposure within a Few Days of Delivery and Placental Abruption in Japan. ( 27922526 )
2016
26
Fetal cerebral and umbilical Doppler in pregnancies complicated by late-onset placental abruption. ( 27484964 )
2016
27
Circulating Levels of Pregnancy-Associated, Placenta-Specific microRNAs in Pregnant Women With Placental Abruption. ( 27297699 )
2016
28
Developmental outcomes in children following placental abruption: novel methods to disentangle causes and mediators. ( 27132247 )
2016
29
Placental Abruption Revealed by Hemoperitoneum: A Case Report. ( 27994944 )
2016
30
Placental genetic variations in circadian clock-related genes increase the risk of placental abruption. ( 27186326 )
2016
31
ASSOCIATION BETWEEN PLACENTAL ABRUPTION AND CAESAREAN SECTION AMONG PATIENTS AT KHYBER TEACHING HOSPITAL PESHAWAR. ( 27323587 )
2016
32
Trauma in pregnant women: assessing detection of post-traumatic placental abruption on contrast-enhanced CT versus ultrasound. ( 27853848 )
2016
33
Poster 46 Multiple Amputations Including Bilateral Transtibial Amputations in a 29-Year-Old Female After Suffering Placental Abruption, GBS Septicemia and DIC: AA Case Report. ( 27672813 )
2016
34
The role of mean platelet volume and platelet distribution width in the prediction of placental abruption. ( 27184035 )
2016
35
Association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with preterm delivery and placental abruption: a systematic review and meta-analysis. ( 26439908 )
2015
36
Severe placental abruption: clinical definition and associations with maternal complications. ( 26393335 )
2015
37
Placental mitochondrial DNA content and placental abruption: a pilot study. ( 26377917 )
2015
38
Coagulopathy and placental abruption: changing management with ROTEM-guided fibrinogen concentrate therapy. ( 25659517 )
2015
39
[231-POS]: Recurrent abruption in hypertensive pregnancy; a case report and historical control study for the mode of delivery after fetal death by placental abruption. ( 25787581 )
2015
40
Spontaneous Splenic Rupture Mimicking Placental Abruption in the Second Trimester: a Case Report and Review of the Literature. ( 27132334 )
2015
41
Placental abruption and long-term maternal cardiovascular disease mortality: a population-based registry study in Norway and Sweden. ( 26177801 )
2015
42
Re: Prenatal vitamin C and E supplementation in smokers is associated with reduced placental abruption and preterm birth: a secondary analysis. ( 25892472 )
2015
43
An international contrast of rates of placental abruption: an age-period-cohort analysis. ( 26018653 )
2015
44
Nonlinear analysis of fetal heart rate dynamics in fetuses compromised by asymptomatic partial placental abruption. ( 26602608 )
2015
45
[186-POS]: Role of coagulation factors in placental abruption in the Chinese population. ( 25787537 )
2015
46
Cesarean Delivery for a Life-threatening Preterm Placental Abruption. ( 27057388 )
2015
47
Change in paternity, risk of placental abruption and confounding by birth interval: a population-based prospective cohort study in Norway, 1967-2009. ( 25670732 )
2015
48
Incidence and recurrence rate of placental abruption: a longitudinal linked national cohort study in the Netherlands. ( 26071916 )
2015
49
Rapid-Sequence Intubation in the Left-Lateral Tilt Position in a Pregnant Woman with Premature Placental Abruption Utilizing a Videolaryngoscope. ( 26199794 )
2015
50
Factor V Leiden, Prothrombin and MTHFR Mutation in Patients with Preeclamsia, Intrauterine Growth Restriction and Placental Abruption. ( 27275292 )
2015

Variations for Placental Abruption

Expression for Placental Abruption

Search GEO for disease gene expression data for Placental Abruption.

Pathways for Placental Abruption

GO Terms for Placental Abruption

Cellular components related to Placental Abruption according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 AGT APOH F2 F5 FLT1 PGF
2 blood microparticle GO:0072562 9.33 AGT F2 SERPINC1
3 extracellular space GO:0005615 9.28 AGT APOH ENG F2 F5 FLT1

Biological processes related to Placental Abruption according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.84 AGT F2 FLT1 PGF
2 angiogenesis GO:0001525 9.74 ENG FLT1 PGF
3 cellular protein metabolic process GO:0044267 9.73 F2 F5 SERPINC1
4 positive regulation of angiogenesis GO:0045766 9.65 ENG FLT1 PGF
5 female pregnancy GO:0007565 9.58 AGT PGF THBD
6 blood coagulation GO:0007596 9.56 F2 F5 SERPINC1 THBD
7 positive regulation of reactive oxygen species metabolic process GO:2000379 9.55 AGT F2
8 sprouting angiogenesis GO:0002040 9.52 ENG PGF
9 positive regulation of collagen biosynthetic process GO:0032967 9.51 ENG F2
10 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.5 AGT F2 FLT1
11 blood coagulation, intrinsic pathway GO:0007597 9.49 APOH F2
12 negative regulation of blood coagulation GO:0030195 9.46 APOH THBD
13 positive regulation of blood coagulation GO:0030194 9.43 APOH F2
14 negative regulation of platelet activation GO:0010544 9.37 F2 THBD
15 regulation of blood coagulation GO:0030193 9.33 APOH F2 SERPINC1
16 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 THBD
17 hemostasis GO:0007599 8.92 F2 F5 SERPINC1 THBD

Molecular functions related to Placental Abruption according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 AGT F2 PGF
2 heparin binding GO:0008201 8.92 APOH F2 PGF SERPINC1

Sources for Placental Abruption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
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60 QIAGEN
65 SNOMED-CT via HPO
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