MCID: PLC006
MIFTS: 41

Placental Choriocarcinoma malady

Summaries for Placental Choriocarcinoma

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32MalaCards
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MalaCards: Placental Choriocarcinoma, also known as choriocarcinoma of the placenta, is related to choriocarcinoma and breast cancer. An important gene associated with Placental Choriocarcinoma is PGRMC1 (progesterone receptor membrane component 1), and among its related pathways are Organic cation/anion/zwitterion transport and Abacavir transport and metabolism. The compounds hdmtx and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and thyroid, and related mouse phenotypes are renal/urinary system and growth/size.

Aliases & Classifications for Placental Choriocarcinoma

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8Disease Ontology, 60UMLS, 39NCIt
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Aliases & Descriptions:

placental choriocarcinoma 8 60
choriocarcinoma of the placenta 8


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Disease Ontology8 DOID:2024
NCIt39 C8893

Related Diseases for Placental Choriocarcinoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Placental Choriocarcinoma:



Diseases related to placental choriocarcinoma

Clinical Features for Placental Choriocarcinoma

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Drugs & Therapeutics for Placental Choriocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Placental Choriocarcinoma

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Anatomical Context for Placental Choriocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Placental Choriocarcinoma:

32
Placenta, Brain, Thyroid, Breast, Testis

Animal Models for Placental Choriocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Placental Choriocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.2SLC19A1, SLC22A2, SLC22A5, SLC6A19, DKK1, MAF
2MP:00053789.0SLC22A5, SLC6A4, SLC6A19, SLC22A3, PLIN1, PLIN2
3MP:00053768.3SLC6A19, PLIN1, SLC22A3, ABCG2, SLC6A4, SLC22A5

Publications for Placental Choriocarcinoma

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50PubMed
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Articles related to Placental Choriocarcinoma:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Efflux transporter mRNA expression profiles in differentiating JEG-3 human choriocarcinoma cells as a placental transport model. (22393837)
2012
2
Stimulation of serotonergic 5-HT2A receptor signaling increases placental aromatase (CYP19) activity and expression in BeWo and JEG-3 human choriocarcinoma cells. (21703684)
2011
3
In vitro approaches to evaluate placental drug transport by using differentiating JEG-3 human choriocarcinoma cells. (20955359)
2011
4
Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell. (21993263)
2011
5
Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization. (21455559)
2011
6
Nitrofurantoin transport by placental choriocarcinoma JAr cells: involvement of BCRP, OATP2B1 and other MDR transporters. (19924425)
2010
7
Expression of mTOR and downstream signalling components in the JEG-3 and BeWo human placental choriocarcinoma cell lines. (19956903)
2010
8
Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells. (19010540)
2009
9
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. (18042733)
2008
10
Induction of endogenous Nrf2/small maf heterodimers by arsenic-mediated stress in placental choriocarcinoma cells. (16487037)
2006
11
Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. (16391323)
2006
12
Comparison of folic acid uptake characteristics by human placental choriocarcinoma cells at acidic and physiological pH. (16900951)
2006
13
Effect of pro-inflammatory cytokines on expression and activity of 11beta-hydroxysteroid dehydrogenase type 2 in cultured human term placental trophoblast and human choriocarcinoma JEG-3 cells. (15979541)
2005
14
Insulin and leptin do not affect fatty acid uptake and metabolism in human placental choriocarcinoma (BeWo) cells. (15919610)
2005
15
Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. (15316089)
2005
16
Insulin stimulates placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase expression in BeWo choriocarcinoma cells. (14749039)
2004
17
Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine. (12657510)
2003
18
Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells. (12445819)
2002
19
Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. (12175968)
2002
20
Expression of adrenomedullin by human placental cytotrophoblasts and choriocarcinoma JAr cells. (11502838)
2001
21
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). (11334847)
2001
22
Interleukin-12 augments cytolytic activity of peripheral and decidual lymphocytes against choriocarcinoma cell lines and primary culture human placental trophoblasts. (10378027)
1999
23
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
24
Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line. (9528682)
1998
25
Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. (9746226)
1998
26
Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. (9808132)
1998
27
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. (9290147)
1997
28
Tyrosine phosphorylation-and epidermal growth factor-dependent regulation of the sodium-coupled amino acid transporter B0 in the human placental choriocarcinoma cell line JAR. (9194569)
1997
29
Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells: role of plasma membrane fatty acid-binding protein. (9458279)
1997
30
Trophoblastic tumors of the testis other than classic choriocarcinoma: "monophasic" choriocarcinoma and placental site trophoblastic tumor: a report of two cases. (9060597)
1997
31
Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell proliferation and c-myc and growth factor expression in human placental choriocarcinoma JEG-3 cells. (9070231)
1997
32
Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. (8702519)
1996
33
Sodium-dependent carnitine transport in human placental choriocarcinoma cells. (8865821)
1996
34
Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters. (8193164)
1994
35
Functional characterization of L-alanine transport in a placental choriocarcinoma cell line (BeWo). (7886021)
1994
36
Characterization of the glycine transport system GLYT 1 in human placental choriocarcinoma cells (JAR). (8075134)
1994
37
Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. (8031869)
1994
38
Calmodulin-dependent modulation of pH sensitivity of the amino acid transport system L in human placental choriocarcinoma cells. (8018698)
1994
39
Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. (8061055)
1994
40
D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells. (8406465)
1993
41
Modulation of the activity of amino acid transport system L by phorbol esters and calmodulin antagonists in a human placental choriocarcinoma cell line. (1324010)
1992
42
In vitro study of placental trophoblast calcium uptake using JEG-3 human choriocarcinoma cells. (1829088)
1991
43
Transport of taurine and its regulation by protein kinase C in the JAR human placental choriocarcinoma cell line. (1854347)
1991
44
Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR). (1714897)
1991
45
Tissue-specific expression and thyroid hormone regulation of the endogenous placental growth hormone variant and chorionic somatomammotropin genes in a human choriocarcinoma cell line. (1708334)
1991
46
Retinoic acid stimulates placental hormone secretion by choriocarcinoma cell lines in vitro. (1702702)
1991
47
Synthesis and secretion of human chorionic gonadotropin and its subunits in choriocarcinoma cells: a comparative study with normal placental cells. (1691720)
1990
48
Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells. (3459156)
1986
49
The prognostic application of HL-A and ABO typing in placental choriocarcinoma. (5377697)
1969
50
IMMUNOLOGICAL STUDIES IN PATIENTS WITH PLACENTAL CHORIOCARCINOMA. (14207839)
1964

Genetic Variations for Placental Choriocarcinoma

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Expression for genes affiliated with Placental Choriocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Placental Choriocarcinoma

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Pathways for genes affiliated with Placental Choriocarcinoma

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53Reactome, 49PharmGKB, 4Cell Signaling Technology
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Compounds for genes affiliated with Placental Choriocarcinoma

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44Novoseek, 11DrugBank, 2BitterDB, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Placental Choriocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1hdmtx4410.5SLC19A1, ABCG2
2Dactinomycin1110.5SLC22A5, ABCG2
3cirazoline4410.4SLC22A5, SLC22A2, SLC22A3
4moxa4410.4SLC22A3, SLC22A5, SLC22A2
5moxonidine4410.4SLC22A5, SLC22A2, SLC22A3
6Histamine Phosphate1110.4SLC22A5, SLC22A3, SLC22A2
7procainamide44 1111.4SLC22A5, SLC22A2, SLC22A3
8thiamine44 2 11 2413.4SLC22A5, SLC22A2, SLC19A1
91 methyl 4 phenylpyridinium4410.4SLC22A2, SLC22A3, SLC6A4
10agmatine44 28 11 2413.4ODC1, SLC22A3, SLC22A2
11guanidine44 11 2412.4SLC22A3, SLC22A5, SLC22A2
12prazosin44 28 49 1113.4SLC22A2, ABCG2, SLC22A3
13chlorpheniramine44 2 11 2413.3SLC6A4, SLC22A2, ODC1
14lamivudine44 1111.3ABCG2, SLC22A3, SLC22A2
15tetraethylammonium44 28 1112.3SLC22A3, SLC22A5, SLC22A2
16probenecid44 28 59 49 1114.3SLC22A2, ABCG2, SLC22A5, SLC19A1
17methamphetamine44 49 1112.3SLC22A5, SLC22A3, SLC6A4
18desipramine44 49 1112.3SLC6A4, SLC22A5, SLC22A3, SLC22A2
19amphetamine44 1111.2SLC22A3, SLC22A5, SLC6A4
20putrescine44 28 11 2413.2SLC22A2, SLC22A3, SLC22A5, ODC1
21cimetidine44 28 1112.2SLC22A2, SLC22A5, SLC22A3, ABCG2
22clonidine44 28 1112.2SLC22A5, SLC6A4, SLC22A3
23corticosterone44 59 2412.2SLC22A5, SLC22A3, SLC22A2, SLC6A4
24oxaliplatin44 49 1112.2ABCG2, SLC22A2, SLC22A3, ODC1
25dopamine44 28 11 2413.2SLC6A4, ODC1, SLC22A5
26nifedipine44 49 28 1113.2SLC22A3, ABCG2, SLC22A5, SLC22A2
27grepafloxacin44 1111.2SLC22A2, SLC22A5
28carnitine4410.2PLIN2, SLC22A3, SLC22A2, SLC22A5
29choline44 11 2412.2SLC6A4, SLC22A3, SLC22A5, SLC22A2
30nicotine44 49 28 1113.2SLC22A5, SLC22A3, SLC22A2, SLC6A4
31glutamate4410.1SLC6A4, SLC6A19, SLC1A5, ERVW-1
32imipramine44 49 28 11 2414.1SLC22A3, SLC22A2, SLC6A4
33verapamil44 49 28 11 2414.1SLC22A2, SLC22A5, SLC22A3, ABCG2, SLC6A4
34norepinephrine44 11 2412.1PLIN1, SLC22A3, SLC6A4, SLC22A5, SLC22A2
35vincristine44 49 1112.1ABCG2, SLC19A1, CGB, ODC1, SLC22A3
36epinephrine44 11 2412.0SLC22A2, SLC22A5, SLC6A4, SLC22A3, ABCG2
37estrogen4410.0SLC6A4
38methotrexate44 49 1112.0CGB, ODC1, SLC19A1, ABCG2
39estradiol44 11 2412.0SLC22A2, SLC22A3, ABCG2, CGB, RPS6KB1
40cisplatin44 49 59 1112.9ABCG2, RPS6KB1, SLC19A1, CGB, SLC22A2
41zidovudine44 1110.9ABCG2, SLC22A2, ERVW-1
42glutamine449.9SLC19A1, SLC1A5, RPS6KB1, ODC1, ABCG2
43vinblastine44 49 1111.8ODC1, ABCG2, SLC22A2
44progesterone44 59 28 11 2413.8DKK1, SLC22A2, SLC22A3, ABCG2, PGRMC1, CGB
45sodium44 2410.8SLC22A2, SLC6A19, SLC22A5, SLC6A4, SLC1A5
46testosterone44 59 11 2412.8SLC22A3, PGRMC1, ABCG2, SLC6A4, CGB, ODC1
47lysine449.8ABCG2, ODC1, SLC19A1, ERVW-1, SLC6A4
48leucine449.6RPS6KB1, ERVW-1, MAF, MAFF, ABCG2
49alanine449.5ERVW-1, SLC1A5, CGB, ABCG2, SLC6A4, SLC19A1
50arginine449.4SLC22A2, ODC1, MAF, ABCG2, SLC22A3, SLC6A4

GO Terms for genes affiliated with Placental Choriocarcinoma

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16Gene Ontology
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Cellular components related to Placental Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.5SLC6A19, SLC6A4, SLC22A2, SLC19A1, SLC1A5, SLC22A3
2plasma membraneGO:0058868.1ERVW-1, DKK1, ABCG2, PLIN2, SLC22A3, SLC6A19

Biological processes related to Placental Choriocarcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1quaternary ammonium group transportGO:01569710.2SLC22A5, SLC22A3
2response to nutrientGO:00758410.0RPS6KB1, SLC6A19, SLC6A4
3drug transmembrane transportGO:00685510.0SLC22A2, SLC22A5, SLC22A3, ABCG2
4organic cation transportGO:0156959.9SLC22A2, SLC22A3
5response to drugGO:0424939.7SLC6A4, PLIN2, ABCG2, RPS6KB1
6transmembrane transportGO:0550859.6ABCG2, SLC22A3, SLC6A19, SLC22A5, SLC22A2, SLC1A5
7small molecule metabolic processGO:0442819.2ODC1, ABCG2, PLIN2, PLIN1, SLC22A3, SLC22A2

Molecular functions related to Placental Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neutral amino acid transmembrane transporter activityGO:01517510.1SLC1A5, SLC6A19
2quaternary ammonium group transmembrane transporter activityGO:0156519.9SLC22A2, SLC22A5, SLC22A3
3organic cation transmembrane transporter activityGO:0151019.9SLC22A2, SLC22A3

Products for genes affiliated with Placental Choriocarcinoma

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Sources for Placental Choriocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet