MCID: PLC006
MIFTS: 33

Placental Choriocarcinoma malady

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Placental Choriocarcinoma

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Aliases & Descriptions for Placental Choriocarcinoma:

Name: Placental Choriocarcinoma 11 13 66
 
Choriocarcinoma of the Placenta 11

Classifications:



External Ids:

Disease Ontology11 DOID:2024
SNOMED-CT60 448401007
NCIt43 C8893

Summaries for Placental Choriocarcinoma

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MalaCards based summary: Placental Choriocarcinoma, also known as choriocarcinoma of the placenta, is related to choriocarcinoma and dental fluorosis. An important gene associated with Placental Choriocarcinoma is SLC19A1 (Solute Carrier Family 19 Member 1), and among its related pathways are Methotrexate Pathway, Pharmacokinetics and Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include placenta, brain and breast, and related mouse phenotypes are liver/biliary system and adipose tissue.

Related Diseases for Placental Choriocarcinoma

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Graphical network of the top 20 diseases related to Placental Choriocarcinoma:



Diseases related to placental choriocarcinoma

Symptoms for Placental Choriocarcinoma

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Drugs & Therapeutics for Placental Choriocarcinoma

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Drugs for Placental Choriocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BevacizumabPhase 21938216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
2
NitroglycerinPhase 214655-63-04510
Synonyms:
1,2,3-Propanetrioltrinitrate
1,2,3-Propanetriyl nitrate
100292-13-5
105469-31-6
55-63-0
80066-48-4
8013-23-8
9010-02-0
AC1L1IBV
Adesitrin
Aldonitrin
Angibid
Angiolingual
Angiplex
Anglix
Angonist
Angorin
Anogesic
Aquo-Trimitrosan
BIDD:GT0142
BRN 1802063
Blasting gelatin
Blasting oil
Buccal
Buccard
C07455
C3H5N3O9
CCRIS 4089
CHEBI:28787
CHEMBL730
CID4510
CPD-143
Cardabid
Cardamist
Cardinit
Cardiodisco
Cellegesic
Chitamite
Colenitral
Cordipatch
Corditrine
Coro-Nitro
D00515
D005996
DB00727
Dauxona
Deponit
Deponit 5
Deponit TTS 10
Deponit TTS 5
Deponit-5
Diafusor
Discotrine
Dynamite
EINECS 200-240-8
Epinitril
GTN
GTN-Pohl
Gepan Nitroglicerin
Gilucor nitro
Gilustenon
Glonoin
Glycerin trinitrate
Glycerine trinitrate
Glycerintrinitrate
Glycerol trinitrate
Glycerol, nitric acid triester
Glyceroli trinitratis
Glyceroltrinitraat
Glyceroltrinitrat
Glyceryl
Glyceryl nitrate
Glyceryl trinitrate
Glycerylnitrat
Glytrin
HMS2094M15
HSDB 30
Herwicard
Herzer
IMX-150
Klavikordal
LS-7741
Lenitral
Lentonitrina
MED-2002
MQX-503
Mi-Trates
Millisrol
Minitram
Minitran
Minitran (TN)
Minitro
Mionitrat
Myocon
Myoglycerin
Myovin
NG
NITRO IV
NK-843
NTG
Natispray
Neos nitro OPT
Niglin
Niglycon
Niong
Niong Retard
Nirmin
Nit-Ret
Nitora
Nitradisc
Nitradisc Pad
Nitradisc TTS
Nitrangin
Nitrek
Nitriderm
Nitriderm TTS
Nitrine-TDC
Nitro Bid
Nitro Dur
Nitro Dur TTS
Nitro Mack Retard
Nitro Retard
Nitro Rorer
Nitro-Bid
Nitro-Dur 10
Nitro-Dur 5
Nitro-Gesanit Retard
Nitro-M-Bid
Nitro-Mack Retard
Nitro-Par
Nitro-Pflaster
Nitro-Span
Nitro-Time
Nitro-bid (TN)
Nitro-dur
Nitro-dur (TN)
Nitro-lent
NitroBid
NitroCor
 
NitroDur
NitroMist
NitroQuick
NitroQuik
Nitroard
Nitrobaat
Nitrobid Oint
Nitrobukal
Nitrocap
NitrocapT.D
NitrocapT.D.
Nitrocard
Nitrocerin
Nitrocine
Nitrocine 5
Nitroclyn
Nitrocontin
Nitrocontin Continus
Nitrocot
Nitroderm
Nitroderm TTS
Nitroderm TTS Ext
Nitroderm TTS-5
Nitrodisc
Nitrodyl
Nitrodyl TTS
Nitrogard
Nitrogard-SR
Nitroglicerina
Nitrogliceryna
Nitroglin
Nitroglycerin
Nitroglycerin (NG)
Nitroglycerin ointment
Nitroglycerin-ACC
Nitroglycerine
Nitroglycerol
Nitroglyn
Nitroject
Nitrol Ointment
Nitrolan
Nitroletten
Nitrolin
Nitrolingual
Nitrolingual Spray
Nitrolowe
Nitromack Retard
Nitromed
Nitromel
Nitromex
Nitromint
Nitromint Aerosol
Nitromint Retard
Nitromist
Nitromist (TN)
Nitronal Aqueous
Nitronet
Nitrong
Nitrong Retard
Nitrong parenteral
Nitrong-SR
Nitropatch
Nitropen
Nitropercuten
Nitroperlinit
Nitroplast
Nitroprol
Nitropront
Nitroprontan
Nitrorectal
Nitroretard
Nitrorex
Nitrospan
Nitrostabilin
Nitrostat
Nitrovis
Nitrozell retard
Nysconitrine
Percutol
Percutol Oint
Percutol Oint.
Perganit
Perglottal
Perlinganit
Plastranit
Polnitrin
Propane-1,2,3-triyl trinitrate
RCRA waste no. P081
Ratiopharm
Rectogesic
SDM No. 17
SK-106N
SK-866
SK-878
Soup
Spirit of glonoin
Susadrin
Suscard
Sustac
Sustak
Sustonit
TNG
Temponitrin
Top-Nitro
Transderm Nitro
Transderm nitro
Transderm-N TTS
Transderm-Nitro TTS
Transderm-nitro
Transderm-nitro (TN)
Transiderm-nitro
Tridil
Tridil sublin
Trinalgon
Trinipatch
Triniplas
Trinitrate, Glyceryl
Trinitrin
Trinitrin Tablets
Trinitrina Erba
Trinitrine
Trinitroglycerin
Trinitroglycerol
Trinitrol
Trinitrolong
Trinitron
Trinitrosan
Turicard
UN0143
UN0144
UN1204
UN3064
UN3319
UNII-G59M7S0WS3
Vascana
Vasoglyn
Vasolator
Vernies
Willong
c0061
nitroglycerin
3
nivolumab254946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab

Interventional clinical trials:

idNameStatusNCT IDPhase
1Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for ChoriocarcinomaNot yet recruitingNCT00294177Phase 4
2Second Curettage in Treating Patients With Persistent Non-Metastatic Gestational Trophoblastic TumorRecruitingNCT00521118Phase 2
3Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)Not yet recruitingNCT02664961Phase 2
4The French National Reference Centre of GTDRecruitingNCT02892877
5Nivolumab and Ipilimumab in Treating Patients With Rare TumorsNot yet recruitingNCT02834013

Search NIH Clinical Center for Placental Choriocarcinoma

Genetic Tests for Placental Choriocarcinoma

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Anatomical Context for Placental Choriocarcinoma

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MalaCards organs/tissues related to Placental Choriocarcinoma:

34
Placenta, Brain, Breast

Animal Models for Placental Choriocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Placental Choriocarcinoma:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6ABCG2, LEP, PLIN1, PLIN2, SLC19A1
2MP:00053758.6ABCG2, LEP, PLIN1, PLIN2
3MP:00053678.3ABCG2, LEP, MAF, SLC19A1, SLC22A2
4MP:00107717.9ABCG2, LEP, MAF, PLIN1, PLIN2, SLC19A1
5MP:00053787.0LEP, MAF, MTHFD1, PLIN1, PLIN2, SLC19A1
6MP:00053765.8ABCG2, LEP, MAF, MTHFD1, MTR, PLIN1

Publications for Placental Choriocarcinoma

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Articles related to Placental Choriocarcinoma:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. (26917260)
2016
2
Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways. (27580989)
2016
3
Green tea (-)-epigallocatechin gallate induced growth inhibition of human placental choriocarcinoma cells. (27208402)
2016
4
Luteolin Inhibits Proliferation and Induces Apoptosis of Human Placental Choriocarcinoma Cells by Blocking the PI3K/AKT Pathway and Regulating Sterol Regulatory Element Binding Protein Activity. (27580988)
2016
5
Activation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor gene expression following DNA demethylation in placental choriocarcinoma and transformed cell lines. (26014898)
2015
6
Quantification of new antiepileptic drugs by liquid chromatography/electrospray ionization tandem mass spectrometry and its application to cellular uptake experiment using human placental choriocarcinoma BeWo cells. (26343016)
2015
7
Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells. (26299783)
2015
8
The impact of TGF-I^1 on the mRNA expression of TI^R I, TI^R II, Smad4 and the invasiveness of the JEG-3 placental choriocarcinoma cell line. (23205135)
2012
9
Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization. (21455559)
2011
10
Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERI^/MTA3/Snail/E-cadherin pathway. (22866146)
2011
11
Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell. (21993263)
2011
12
Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. (20736774)
2010
13
Nitrofurantoin transport by placental choriocarcinoma JAr cells: involvement of BCRP, OATP2B1 and other MDR transporters. (19924425)
2010
14
Expression of mTOR and downstream signalling components in the JEG-3 and BeWo human placental choriocarcinoma cell lines. (19956903)
2010
15
Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells. (19010540)
2009
16
Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. (19880178)
2009
17
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. (18042733)
2008
18
Incidental placental choriocarcinoma in a term pregnancy: a case report. (18922186)
2008
19
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. (16632463)
2006
20
Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. (16391323)
2006
21
Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling. (17026960)
2006
22
Induction of endogenous Nrf2/small maf heterodimers by arsenic-mediated stress in placental choriocarcinoma cells. (16487037)
2006
23
Insulin and leptin do not affect fatty acid uptake and metabolism in human placental choriocarcinoma (BeWo) cells. (15919610)
2005
24
Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. (15316089)
2005
25
Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine. (12657510)
2003
26
Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. (12538089)
2003
27
Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells. (12445819)
2002
28
Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells. (12050258)
2002
29
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). (11334847)
2001
30
Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line. (9528682)
1998
31
Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. (9746226)
1998
32
Tyrosine phosphorylation-and epidermal growth factor-dependent regulation of the sodium-coupled amino acid transporter B0 in the human placental choriocarcinoma cell line JAR. (9194569)
1997
33
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. (9290147)
1997
34
Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells: role of plasma membrane fatty acid-binding protein. (9458279)
1997
35
Sodium-dependent carnitine transport in human placental choriocarcinoma cells. (8865821)
1996
36
JAR human placental choriocarcinoma cells actively synthesize, take up and release polyamines. (8888570)
1996
37
Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. (8702519)
1996
38
Substrate-specific regulation of the taurine transporter in human placental choriocarcinoma cells (JAR). (7756345)
1995
39
Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters. (8193164)
1994
40
Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. (8182048)
1994
41
Functional characterization of L-alanine transport in a placental choriocarcinoma cell line (BeWo). (7886021)
1994
42
Characterization of the glycine transport system GLYT 1 in human placental choriocarcinoma cells (JAR). (8075134)
1994
43
Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. (8031869)
1994
44
Calmodulin-dependent modulation of pH sensitivity of the amino acid transport system L in human placental choriocarcinoma cells. (8018698)
1994
45
Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. (8408014)
1993
46
Transport of taurine and its regulation by protein kinase C in the JAR human placental choriocarcinoma cell line. (1854347)
1991
47
Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR). (1714897)
1991
48
Successful treatment of placental choriocarcinoma metastatic to brain followed by primary brain glioblastoma. (7060984)
1982
49
The prognostic application of HL-A and ABO typing in placental choriocarcinoma. (5377697)
1969
50
IMMUNOLOGICAL STUDIES IN PATIENTS WITH PLACENTAL CHORIOCARCINOMA. (14207839)
1964

Variations for Placental Choriocarcinoma

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Expression for genes affiliated with Placental Choriocarcinoma

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Search GEO for disease gene expression data for Placental Choriocarcinoma.

Pathways for genes affiliated with Placental Choriocarcinoma

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Pathways related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.9ABCG2, SLC19A1
29.8ABCG2, SLC22A2
3
Show member pathways
9.8ABCG2, SLC22A2
49.1ABCG2, LEP, PLIN2
58.9LEP, PLIN1, PLIN2
6
Show member pathways
8.8MTHFD1, MTR, SLC19A1
7
Show member pathways
7.2ABCG2, MTHFD1, MTR, PLIN1, PLIN2, SLC19A1

GO Terms for genes affiliated with Placental Choriocarcinoma

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Cellular components related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1presynapseGO:00987939.8SLC22A2, SLC6A4
2lipid particleGO:00058119.2PLIN1, PLIN2

Biological processes related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1drug transmembrane transportGO:000685510.3ABCG2, SLC22A2
2folic acid metabolic processGO:00466559.8MTHFD1, SLC19A1
3methionine biosynthetic processGO:00090869.8MTHFD1, MTR
4cellular response to retinoic acidGO:00713009.7LEP, SLC6A4
5response to drugGO:00424939.4ABCG2, PLIN2, SLC6A4

Sources for Placental Choriocarcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet