MCID: PLC006
MIFTS: 41

Placental Choriocarcinoma malady

Summaries for Placental Choriocarcinoma

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32MalaCards
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MalaCards: Placental Choriocarcinoma, also known as choriocarcinoma of the placenta, is related to choriocarcinoma and breast cancer. An important gene associated with Placental Choriocarcinoma is PGRMC1 (progesterone receptor membrane component 1), and among its related pathways are Organic cation/anion/zwitterion transport and Abacavir transport and metabolism. The compounds hdmtx and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and thyroid, and related mouse phenotypes are renal/urinary system and growth/size.

Aliases & Classifications for Placental Choriocarcinoma

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8Disease Ontology, 60UMLS, 39NCIt
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Aliases & Descriptions:

placental choriocarcinoma 8 60
choriocarcinoma of the placenta 8


External Ids:

Disease Ontology8 DOID:2024
NCIt39 C8893

Related Diseases for Placental Choriocarcinoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Placental Choriocarcinoma:



Diseases related to placental choriocarcinoma

Clinical Features for Placental Choriocarcinoma

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Drugs & Therapeutics for Placental Choriocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Placental Choriocarcinoma

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Genetic Tests for Placental Choriocarcinoma

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Anatomical Context for Placental Choriocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Placental Choriocarcinoma:

32
Placenta, Brain, Thyroid, Breast, Testis

Animal Models for Placental Choriocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Placental Choriocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.2MAF, DKK1, SLC6A19, SLC22A5, SLC22A2, SLC19A1
2MP:00053789.0MAF, PLIN2, PLIN1, SLC22A3, SLC6A19, SLC6A4
3MP:00053768.3SLC19A1, RPS6KB1, MAF, DKK1, ABCG2, PLIN2

Publications for Placental Choriocarcinoma

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50PubMed
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Articles related to Placental Choriocarcinoma:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
The impact of TGF-I^1 on the mRNA expression of TI^R I, TI^R II, Smad4 and the invasiveness of the JEG-3 placental choriocarcinoma cell line. (23205135)
2012
2
Efflux transporter mRNA expression profiles in differentiating JEG-3 human choriocarcinoma cells as a placental transport model. (22393837)
2012
3
Inhibition of Akt activity and calcium channel function coordinately drive cell-cell fusion in the BeWO choriocarcinoma placental cell line. (22276109)
2012
4
In vitro approaches to evaluate placental drug transport by using differentiating JEG-3 human choriocarcinoma cells. (20955359)
2011
5
Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell. (21993263)
2011
6
Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERI^/MTA3/Snail/E-cadherin pathway. (22866146)
2011
7
Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. (20736774)
2010
8
Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. (19880178)
2009
9
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. (18042733)
2008
10
Incidental placental choriocarcinoma in a term pregnancy: a case report. (18922186)
2008
11
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. (16632463)
2006
12
Induction of endogenous Nrf2/small maf heterodimers by arsenic-mediated stress in placental choriocarcinoma cells. (16487037)
2006
13
Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling. (17026960)
2006
14
Comparison of folic acid uptake characteristics by human placental choriocarcinoma cells at acidic and physiological pH. (16900951)
2006
15
Effect of pro-inflammatory cytokines on expression and activity of 11beta-hydroxysteroid dehydrogenase type 2 in cultured human term placental trophoblast and human choriocarcinoma JEG-3 cells. (15979541)
2005
16
Insulin and leptin do not affect fatty acid uptake and metabolism in human placental choriocarcinoma (BeWo) cells. (15919610)
2005
17
Insulin stimulates placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase expression in BeWo choriocarcinoma cells. (14749039)
2004
18
Interleukin-1beta stimulates placental leucine aminopeptidase/oxytocinase expression in BeWo choriocarcinoma cells. (12569180)
2003
19
Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. (12538089)
2003
20
Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells. (12445819)
2002
21
Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells. (12050258)
2002
22
Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. (12175968)
2002
23
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). (11334847)
2001
24
Interleukin-12 augments cytolytic activity of peripheral and decidual lymphocytes against choriocarcinoma cell lines and primary culture human placental trophoblasts. (10378027)
1999
25
Expression of CD1D mRNA transcripts in human choriocarcinoma cell lines and placentally derived trophoblast cells. (10233754)
1999
26
Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells. (10502498)
1999
27
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
28
Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line. (9528682)
1998
29
Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. (9746226)
1998
30
Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. (9808132)
1998
31
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. (9290147)
1997
32
Tyrosine phosphorylation-and epidermal growth factor-dependent regulation of the sodium-coupled amino acid transporter B0 in the human placental choriocarcinoma cell line JAR. (9194569)
1997
33
Trophoblastic tumors of the testis other than classic choriocarcinoma: "monophasic" choriocarcinoma and placental site trophoblastic tumor: a report of two cases. (9060597)
1997
34
Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. (8702519)
1996
35
Sodium-dependent carnitine transport in human placental choriocarcinoma cells. (8865821)
1996
36
JAR human placental choriocarcinoma cells actively synthesize, take up and release polyamines. (8888570)
1996
37
Substrate-specific regulation of the taurine transporter in human placental choriocarcinoma cells (JAR). (7756345)
1995
38
Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters. (8193164)
1994
39
Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. (8182048)
1994
40
Functional characterization of L-alanine transport in a placental choriocarcinoma cell line (BeWo). (7886021)
1994
41
Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. (8031869)
1994
42
Calmodulin-dependent modulation of pH sensitivity of the amino acid transport system L in human placental choriocarcinoma cells. (8018698)
1994
43
Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. (8061055)
1994
44
Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. (7691711)
1993
45
Differential expression of human placental growth hormone variant and chorionic somatomammotropin genes in choriocarcinoma cells treated with methotrexate. (8472847)
1993
46
Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. (8408014)
1993
47
Modulation of the activity of amino acid transport system L by phorbol esters and calmodulin antagonists in a human placental choriocarcinoma cell line. (1324010)
1992
48
Transport of taurine and its regulation by protein kinase C in the JAR human placental choriocarcinoma cell line. (1854347)
1991
49
Trophoblastic tumors: ultrastructural comparison of choriocarcinoma and placental-site trophoblastic tumor. (2539322)
1989
50
Successful treatment of placental choriocarcinoma metastatic to brain followed by primary brain glioblastoma. (7060984)
1982

Genetic Variations for Placental Choriocarcinoma

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Expression for genes affiliated with Placental Choriocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Placental Choriocarcinoma

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Pathways for genes affiliated with Placental Choriocarcinoma

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53Reactome, 49PharmGKB, 4Cell Signaling Technology
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Compounds for genes affiliated with Placental Choriocarcinoma

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44Novoseek, 11DrugBank, 2BitterDB, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Placental Choriocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1hdmtx4410.5SLC19A1, ABCG2
2Dactinomycin1110.5SLC22A5, ABCG2
3cirazoline4410.4SLC22A5, SLC22A2, SLC22A3
4moxa4410.4SLC22A3, SLC22A5, SLC22A2
5moxonidine4410.4SLC22A5, SLC22A2, SLC22A3
6Histamine Phosphate1110.4SLC22A5, SLC22A3, SLC22A2
7procainamide44 1111.4SLC22A5, SLC22A2, SLC22A3
8thiamine44 2 11 2413.4SLC22A5, SLC22A2, SLC19A1
91 methyl 4 phenylpyridinium4410.4SLC22A2, SLC22A3, SLC6A4
10agmatine44 28 11 2413.4ODC1, SLC22A3, SLC22A2
11guanidine44 11 2412.4SLC22A3, SLC22A5, SLC22A2
12prazosin44 28 49 1113.4SLC22A2, ABCG2, SLC22A3
13chlorpheniramine44 2 11 2413.3SLC6A4, SLC22A2, ODC1
14lamivudine44 1111.3ABCG2, SLC22A3, SLC22A2
15tetraethylammonium44 28 1112.3SLC22A3, SLC22A5, SLC22A2
16probenecid44 28 59 49 1114.3SLC22A2, ABCG2, SLC22A5, SLC19A1
17methamphetamine44 49 1112.3SLC22A5, SLC22A3, SLC6A4
18desipramine44 49 1112.3SLC6A4, SLC22A5, SLC22A3, SLC22A2
19amphetamine44 1111.2SLC22A3, SLC22A5, SLC6A4
20putrescine44 28 11 2413.2SLC22A2, SLC22A3, SLC22A5, ODC1
21cimetidine44 28 1112.2SLC22A2, SLC22A5, SLC22A3, ABCG2
22clonidine44 28 1112.2SLC22A5, SLC6A4, SLC22A3
23corticosterone44 59 2412.2SLC22A5, SLC22A3, SLC22A2, SLC6A4
24oxaliplatin44 49 1112.2ABCG2, SLC22A2, SLC22A3, ODC1
25dopamine44 28 11 2413.2SLC6A4, ODC1, SLC22A5
26nifedipine44 49 28 1113.2SLC22A3, ABCG2, SLC22A5, SLC22A2
27grepafloxacin44 1111.2SLC22A2, SLC22A5
28carnitine4410.2PLIN2, SLC22A3, SLC22A2, SLC22A5
29choline44 11 2412.2SLC6A4, SLC22A3, SLC22A5, SLC22A2
30nicotine44 49 28 1113.2SLC22A5, SLC22A3, SLC22A2, SLC6A4
31glutamate4410.1SLC6A4, SLC6A19, SLC1A5, ERVW-1
32imipramine44 49 28 11 2414.1SLC22A3, SLC22A2, SLC6A4
33verapamil44 49 28 11 2414.1SLC22A2, SLC22A5, SLC22A3, ABCG2, SLC6A4
34norepinephrine44 11 2412.1PLIN1, SLC22A3, SLC6A4, SLC22A5, SLC22A2
35vincristine44 49 1112.1ABCG2, SLC19A1, CGB, ODC1, SLC22A3
36epinephrine44 11 2412.0SLC22A2, SLC22A5, SLC6A4, SLC22A3, ABCG2
37estrogen4410.0SLC6A4
38methotrexate44 49 1112.0CGB, ODC1, SLC19A1, ABCG2
39estradiol44 11 2412.0SLC22A2, SLC22A3, ABCG2, CGB, RPS6KB1
40cisplatin44 49 59 1112.9ABCG2, RPS6KB1, SLC19A1, CGB, SLC22A2
41zidovudine44 1110.9ABCG2, SLC22A2, ERVW-1
42glutamine449.9SLC19A1, SLC1A5, RPS6KB1, ODC1, ABCG2
43vinblastine44 49 1111.8ODC1, ABCG2, SLC22A2
44progesterone44 59 28 11 2413.8DKK1, SLC22A2, SLC22A3, ABCG2, PGRMC1, CGB
45sodium44 2410.8SLC22A2, SLC6A19, SLC22A5, SLC6A4, SLC1A5
46testosterone44 59 11 2412.8SLC22A3, PGRMC1, ABCG2, SLC6A4, CGB, ODC1
47lysine449.8ABCG2, ODC1, SLC19A1, ERVW-1, SLC6A4
48leucine449.6RPS6KB1, ERVW-1, MAF, MAFF, ABCG2
49alanine449.5ERVW-1, SLC1A5, CGB, ABCG2, SLC6A4, SLC19A1
50arginine449.4SLC22A2, ODC1, MAF, ABCG2, SLC22A3, SLC6A4

GO Terms for genes affiliated with Placental Choriocarcinoma

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16Gene Ontology
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Cellular components related to Placental Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.5SLC6A19, SLC6A4, SLC22A2, SLC19A1, SLC1A5, SLC22A3
2plasma membraneGO:0058868.1ERVW-1, DKK1, ABCG2, PLIN2, SLC22A3, SLC6A19

Biological processes related to Placental Choriocarcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1quaternary ammonium group transportGO:01569710.2SLC22A5, SLC22A3
2response to nutrientGO:00758410.0RPS6KB1, SLC6A19, SLC6A4
3drug transmembrane transportGO:00685510.0SLC22A2, SLC22A5, SLC22A3, ABCG2
4organic cation transportGO:0156959.9SLC22A2, SLC22A3
5response to drugGO:0424939.7SLC6A4, PLIN2, ABCG2, RPS6KB1
6transmembrane transportGO:0550859.6ABCG2, SLC22A3, SLC6A19, SLC22A5, SLC22A2, SLC1A5
7small molecule metabolic processGO:0442819.2ODC1, ABCG2, PLIN2, PLIN1, SLC22A3, SLC22A2

Molecular functions related to Placental Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neutral amino acid transmembrane transporter activityGO:01517510.1SLC1A5, SLC6A19
2quaternary ammonium group transmembrane transporter activityGO:0156519.9SLC22A2, SLC22A5, SLC22A3
3organic cation transmembrane transporter activityGO:0151019.9SLC22A2, SLC22A3

Products for genes affiliated with Placental Choriocarcinoma

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Sources for Placental Choriocarcinoma

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3CDC
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14FMA
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23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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