MCID: PLC006
MIFTS: 37

Placental Choriocarcinoma malady

Summaries for Placental Choriocarcinoma

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33MalaCards
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MalaCards: Placental Choriocarcinoma, also known as choriocarcinoma of the placenta, is related to cholera and progesterone resistance. An important gene associated with Placental Choriocarcinoma is PGRMC1 (progesterone receptor membrane component 1), and among its related pathways are Organic cation/anion/zwitterion transport and Abacavir transport and metabolism. The compounds hdmtx and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and breast, and related mouse phenotypes are renal/urinary system and growth/size.

Aliases & Classifications for Placental Choriocarcinoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt
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Aliases & Descriptions:

placental choriocarcinoma 8 61
choriocarcinoma of the placenta 8


External Ids:

Disease Ontology8 DOID:2024
NCIt40 C8893

Related Diseases for Placental Choriocarcinoma

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Placental Choriocarcinoma:



Diseases related to placental choriocarcinoma

Clinical Features for Placental Choriocarcinoma

Drugs & Therapeutics for Placental Choriocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Placental Choriocarcinoma

Drug clinical trials:

Search ClinicalTrials for Placental Choriocarcinoma

Search NIH Clinical Center for Placental Choriocarcinoma

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Genetic Tests for Placental Choriocarcinoma

Anatomical Context for Placental Choriocarcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Placental Choriocarcinoma:

33
Brain, Thyroid, Breast, Placenta, Testis, B cells

Animal Models for Placental Choriocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Placental Choriocarcinoma

Sources:
51PubMed
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Articles related to Placental Choriocarcinoma:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
The impact of TGF-I^1 on the mRNA expression of TI^R I, TI^R II, Smad4 and the invasiveness of the JEG-3 placental choriocarcinoma cell line. (23205135)
2012
2
Efflux transporter mRNA expression profiles in differentiating JEG-3 human choriocarcinoma cells as a placental transport model. (22393837)
2012
3
In vitro approaches to evaluate placental drug transport by using differentiating JEG-3 human choriocarcinoma cells. (20955359)
2011
4
Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell. (21993263)
2011
5
Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization. (21455559)
2011
6
Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERI^/MTA3/Snail/E-cadherin pathway. (22866146)
2011
7
Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. (20736774)
2010
8
Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. (19880178)
2009
9
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. (18042733)
2008
10
Incidental placental choriocarcinoma in a term pregnancy: a case report. (18922186)
2008
11
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. (16632463)
2006
12
Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. (16391323)
2006
13
Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling. (17026960)
2006
14
Comparison of folic acid uptake characteristics by human placental choriocarcinoma cells at acidic and physiological pH. (16900951)
2006
15
Insulin and leptin do not affect fatty acid uptake and metabolism in human placental choriocarcinoma (BeWo) cells. (15919610)
2005
16
Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. (15316089)
2005
17
Insulin stimulates placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase expression in BeWo choriocarcinoma cells. (14749039)
2004
18
Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine. (12657510)
2003
19
Interleukin-1beta stimulates placental leucine aminopeptidase/oxytocinase expression in BeWo choriocarcinoma cells. (12569180)
2003
20
Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. (12538089)
2003
21
Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells. (12445819)
2002
22
Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells. (12050258)
2002
23
Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. (12175968)
2002
24
Expression of adrenomedullin by human placental cytotrophoblasts and choriocarcinoma JAr cells. (11502838)
2001
25
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). (11334847)
2001
26
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
27
Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line. (9528682)
1998
28
Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. (9746226)
1998
29
Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. (9808132)
1998
30
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. (9290147)
1997
31
Tyrosine phosphorylation-and epidermal growth factor-dependent regulation of the sodium-coupled amino acid transporter B0 in the human placental choriocarcinoma cell line JAR. (9194569)
1997
32
Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters. (8193164)
1994
33
Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. (8182048)
1994
34
Functional characterization of L-alanine transport in a placental choriocarcinoma cell line (BeWo). (7886021)
1994
35
Characterization of the glycine transport system GLYT 1 in human placental choriocarcinoma cells (JAR). (8075134)
1994
36
Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. (8031869)
1994
37
Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. (8061055)
1994
38
Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. (7691711)
1993
39
Differential expression of human placental growth hormone variant and chorionic somatomammotropin genes in choriocarcinoma cells treated with methotrexate. (8472847)
1993
40
Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. (8408014)
1993
41
D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells. (8406465)
1993
42
In vitro study of placental trophoblast calcium uptake using JEG-3 human choriocarcinoma cells. (1829088)
1991
43
Transport of taurine and its regulation by protein kinase C in the JAR human placental choriocarcinoma cell line. (1854347)
1991
44
Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR). (1714897)
1991
45
Tissue-specific expression and thyroid hormone regulation of the endogenous placental growth hormone variant and chorionic somatomammotropin genes in a human choriocarcinoma cell line. (1708334)
1991
46
Retinoic acid stimulates placental hormone secretion by choriocarcinoma cell lines in vitro. (1702702)
1991
47
Synthesis and secretion of human chorionic gonadotropin and its subunits in choriocarcinoma cells: a comparative study with normal placental cells. (1691720)
1990
48
Trophoblastic tumors: ultrastructural comparison of choriocarcinoma and placental-site trophoblastic tumor. (2539322)
1989
49
Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells. (3459156)
1986
50
The prognostic application of HL-A and ABO typing in placental choriocarcinoma. (5377697)
1969

Genetic Variations for Placental Choriocarcinoma

Expression for genes affiliated with Placental Choriocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Placental Choriocarcinoma

Search GEO for disease gene expression data for Placental Choriocarcinoma.

Pathways for genes affiliated with Placental Choriocarcinoma

Sources:
54Reactome, 50PharmGKB, 4Cell Signaling Technology
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Compounds for genes affiliated with Placental Choriocarcinoma

Sources:
45Novoseek, 11DrugBank, 2BitterDB, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Placental Choriocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1hdmtx4510.5SLC19A1, ABCG2
2Dactinomycin1110.5SLC22A5, ABCG2
3cirazoline4510.4SLC22A5, SLC22A2, SLC22A3
4moxa4510.4SLC22A3, SLC22A5, SLC22A2
5moxonidine4510.4SLC22A5, SLC22A2, SLC22A3
6Histamine Phosphate1110.4SLC22A5, SLC22A3, SLC22A2
7procainamide45 1111.4SLC22A5, SLC22A2, SLC22A3
8thiamine45 2 11 2413.4SLC22A5, SLC22A2, SLC19A1
91 methyl 4 phenylpyridinium4510.4SLC22A2, SLC22A3, SLC6A4
10agmatine45 29 11 2413.4ODC1, SLC22A3, SLC22A2
11guanidine45 11 2412.4SLC22A3, SLC22A5, SLC22A2
12prazosin45 29 50 1113.4SLC22A2, ABCG2, SLC22A3
13chlorpheniramine45 2 11 2413.3SLC6A4, SLC22A2, ODC1
14lamivudine45 1111.3ABCG2, SLC22A3, SLC22A2
15tetraethylammonium45 29 1112.3SLC22A3, SLC22A5, SLC22A2
16probenecid45 29 60 50 1114.3SLC22A2, ABCG2, SLC22A5, SLC19A1
17methamphetamine45 50 1112.3SLC22A5, SLC22A3, SLC6A4
18desipramine45 50 1112.3SLC6A4, SLC22A5, SLC22A3, SLC22A2
19amphetamine45 1111.2SLC22A3, SLC22A5, SLC6A4
20putrescine45 29 11 2413.2SLC22A2, SLC22A3, SLC22A5, ODC1
21cimetidine45 29 1112.2SLC22A2, SLC22A5, SLC22A3, ABCG2
22clonidine45 29 1112.2SLC22A5, SLC6A4, SLC22A3
23corticosterone45 60 2412.2SLC22A5, SLC22A3, SLC22A2, SLC6A4
24oxaliplatin45 50 1112.2ABCG2, SLC22A2, SLC22A3, ODC1
25dopamine45 29 11 2413.2SLC6A4, ODC1, SLC22A5
26nifedipine45 50 29 1113.2SLC22A3, ABCG2, SLC22A5, SLC22A2
27grepafloxacin45 1111.2SLC22A2, SLC22A5
28carnitine4510.2PLIN2, SLC22A3, SLC22A2, SLC22A5
29choline45 11 2412.2SLC6A4, SLC22A3, SLC22A5, SLC22A2
30nicotine45 50 29 1113.2SLC22A5, SLC22A3, SLC22A2, SLC6A4
31glutamate4510.1SLC6A4, SLC6A19, SLC1A5, ERVW-1
32imipramine45 50 29 11 2414.1SLC22A3, SLC22A2, SLC6A4
33verapamil45 50 29 11 2414.1SLC22A2, SLC22A5, SLC22A3, ABCG2, SLC6A4
34norepinephrine45 11 2412.1PLIN1, SLC22A3, SLC6A4, SLC22A5, SLC22A2
35vincristine45 50 1112.1ABCG2, SLC19A1, CGB, ODC1, SLC22A3
36epinephrine45 11 2412.0SLC22A2, SLC22A5, SLC6A4, SLC22A3, ABCG2
37estrogen4510.0SLC6A4
38methotrexate45 50 1112.0CGB, ODC1, SLC19A1, ABCG2
39estradiol45 11 2412.0SLC22A2, SLC22A3, ABCG2, CGB, RPS6KB1
40cisplatin45 50 60 1112.9ABCG2, RPS6KB1, SLC19A1, CGB, SLC22A2
41zidovudine45 1110.9ABCG2, SLC22A2, ERVW-1
42glutamine459.9SLC19A1, SLC1A5, RPS6KB1, ODC1, ABCG2
43vinblastine45 50 1111.8ODC1, ABCG2, SLC22A2
44progesterone45 60 29 11 2413.8DKK1, SLC22A2, SLC22A3, ABCG2, PGRMC1, CGB
45sodium45 2410.8SLC22A2, SLC6A19, SLC22A5, SLC6A4, SLC1A5
46testosterone45 60 11 2412.8SLC22A3, PGRMC1, ABCG2, SLC6A4, CGB, ODC1
47lysine459.8ABCG2, ODC1, SLC19A1, ERVW-1, SLC6A4
48leucine459.6RPS6KB1, ERVW-1, MAF, MAFF, ABCG2
49alanine459.5ERVW-1, SLC1A5, CGB, ABCG2, SLC6A4, SLC19A1
50arginine459.4SLC22A2, ODC1, MAF, ABCG2, SLC22A3, SLC6A4

GO Terms for genes affiliated with Placental Choriocarcinoma

Sources:
16Gene Ontology
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Cellular components related to Placental Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.5SLC6A19, SLC6A4, SLC22A2, SLC19A1, SLC1A5, SLC22A3
2plasma membraneGO:0058868.1ERVW-1, DKK1, ABCG2, PLIN2, SLC22A3, SLC6A19

Biological processes related to Placental Choriocarcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1quaternary ammonium group transportGO:01569710.2SLC22A5, SLC22A3
2response to nutrientGO:00758410.0RPS6KB1, SLC6A19, SLC6A4
3drug transmembrane transportGO:00685510.0SLC22A2, SLC22A5, SLC22A3, ABCG2
4organic cation transportGO:0156959.9SLC22A2, SLC22A3
5response to drugGO:0424939.7SLC6A4, PLIN2, ABCG2, RPS6KB1
6transmembrane transportGO:0550859.6ABCG2, SLC22A3, SLC6A19, SLC22A5, SLC22A2, SLC1A5
7small molecule metabolic processGO:0442819.2ODC1, ABCG2, PLIN2, PLIN1, SLC22A3, SLC22A2

Molecular functions related to Placental Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neutral amino acid transmembrane transporter activityGO:01517510.1SLC1A5, SLC6A19
2quaternary ammonium group transmembrane transporter activityGO:0156519.9SLC22A2, SLC22A5, SLC22A3
3organic cation transmembrane transporter activityGO:0151019.9SLC22A2, SLC22A3

Products for genes affiliated with Placental Choriocarcinoma

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Sources for Placental Choriocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet