MCID: PLC006
MIFTS: 33

Placental Choriocarcinoma

Categories: Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Placental Choriocarcinoma

MalaCards integrated aliases for Placental Choriocarcinoma:

Name: Placental Choriocarcinoma 12 14 69
Choriocarcinoma of the Placenta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2024
NCIt 47 C8893
SNOMED-CT 64 448401007
UMLS 69 C0855173

Summaries for Placental Choriocarcinoma

MalaCards based summary : Placental Choriocarcinoma, also known as choriocarcinoma of the placenta, is related to choriocarcinoma and encephalomalacia. An important gene associated with Placental Choriocarcinoma is SLC19A1 (Solute Carrier Family 19 Member 1), and among its related pathways/superpathways are Adipogenesis and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. The drugs Chorionic Gonadotropin and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include placenta and brain, and related phenotypes are homeostasis/metabolism and integument

Related Diseases for Placental Choriocarcinoma

Diseases related to Placental Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
id Related Disease Score Top Affiliating Genes
1 choriocarcinoma 10.6
2 encephalomalacia 10.4 ABCG2 SLC6A4
3 anodontia 10.3 LEP SLC6A4
4 adult t-cell leukemia 10.2 ABCG2 MTR
5 homologous wasting disease 10.2 MTR SLC19A1
6 perinatal necrotizing enterocolitis 10.1 LEP SLC6A4
7 fallopian tube germ cell cancer 10.0 PLIN1 PLIN2
8 lissencephaly 9.9 LEP PLIN1
9 celiac disease 9 9.8 PLIN1 PLIN2
10 chagas disease 9.8 LEP SLC6A4
11 breast cancer 9.7
12 cholera 9.7
13 glioblastoma 9.7
14 benign ependymoma 9.7 PLIN1 PLIN2
15 anxiety disorder 6.1 ABCG2 DKK1 LEP MAF MAFF MTR

Graphical network of the top 20 diseases related to Placental Choriocarcinoma:



Diseases related to Placental Choriocarcinoma

Symptoms & Phenotypes for Placental Choriocarcinoma

MGI Mouse Phenotypes related to Placental Choriocarcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 ABCG2 DKK1 LEP MAF MTR PLIN1
2 integument MP:0010771 9.7 ABCG2 LEP MAF PLIN1 PLIN2 SLC19A1
3 liver/biliary system MP:0005370 9.35 ABCG2 LEP PLIN1 PLIN2 SLC19A1
4 renal/urinary system MP:0005367 9.1 ABCG2 DKK1 LEP MAF SLC19A1 SLC22A2

Drugs & Therapeutics for Placental Choriocarcinoma

Drugs for Placental Choriocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Chorionic Gonadotropin Phase 4
2
Levoleucovorin Approved Phase 2, Phase 3 68538-85-2
3
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
5
leucovorin Approved, Nutraceutical Phase 2, Phase 3 58-05-9 143 6006
6 Antidotes Phase 2, Phase 3
7 Antimetabolites Phase 2, Phase 3
8 Antimetabolites, Antineoplastic Phase 2, Phase 3
9 Antirheumatic Agents Phase 2, Phase 3
10 Dermatologic Agents Phase 2, Phase 3
11 Folic Acid Antagonists Phase 2, Phase 3
12 Hematinics Phase 2, Phase 3
13 Immunosuppressive Agents Phase 2, Phase 3
14 Micronutrients Phase 2, Phase 3
15 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
16 Protective Agents Phase 2, Phase 3
17 Trace Elements Phase 2, Phase 3
18 Vitamin B Complex Phase 2, Phase 3
19 Vitamins Phase 2, Phase 3
20 Folate Nutraceutical Phase 2, Phase 3
21 Vitamin B9 Nutraceutical Phase 2, Phase 3
22
nivolumab Approved Phase 2 946414-94-4
23
Bevacizumab Approved, Investigational Phase 2 216974-75-3
24
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
25 Antibodies Phase 2
26 Antibodies, Monoclonal Phase 2
27 Immunoglobulins Phase 2
28 Angiogenesis Inhibitors Phase 2
29 Angiogenesis Modulating Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177 Phase 4
2 Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia Not yet recruiting NCT03280979 Phase 2, Phase 3 rescue regimen;high dose methotrxate
3 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
4 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2 TRC105;Bevacizumab
5 The French National Reference Centre of GTD Recruiting NCT02892877

Search NIH Clinical Center for Placental Choriocarcinoma

Genetic Tests for Placental Choriocarcinoma

Anatomical Context for Placental Choriocarcinoma

MalaCards organs/tissues related to Placental Choriocarcinoma:

39
Placenta, Brain

Publications for Placental Choriocarcinoma

Articles related to Placental Choriocarcinoma:

(show top 50) (show all 62)
id Title Authors Year
1
Activation of Peroxisome Proliferator-Activated Receptor Gamma and Disruption of Progesterone Synthesis of 2-Ethylhexyl Diphenyl Phosphate in Human Placental Choriocarcinoma Cells: Comparison with Triphenyl Phosphate. ( 28282128 )
2017
2
Treatment of Human Placental Choriocarcinoma Cells with Formaldehyde and Benzene Induced Growth and Epithelial Mesenchymal Transition via Induction of an Antioxidant Effect. ( 28758930 )
2017
3
Fatty acid-binding protein3 expression in BeWo cells, a human placental choriocarcinoma cell line. ( 28515017 )
2017
4
Myricetin suppresses invasion and promotes cell death in human placental choriocarcinoma cells through induction of oxidative stress. ( 28428076 )
2017
5
Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. ( 26917260 )
2016
6
Green tea (-)-epigallocatechin gallate induced growth inhibition of human placental choriocarcinoma cells. ( 27208402 )
2016
7
Involvement of l-type amino acid transporter 1 in the transport of gabapentin into human placental choriocarcinoma cells. ( 27818298 )
2016
8
Luteolin Inhibits Proliferation and Induces Apoptosis of Human Placental Choriocarcinoma Cells by Blocking the PI3K/AKT Pathway and Regulating Sterol Regulatory Element Binding Protein Activity. ( 27580988 )
2016
9
Corrigendum to "Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (Bewo) cells" [Placenta (2009) 1037-1044]. ( 27623544 )
2016
10
Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways. ( 27580989 )
2016
11
Activation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor gene expression following DNA demethylation in placental choriocarcinoma and transformed cell lines. ( 26014898 )
2015
12
Quantification of new antiepileptic drugs by liquid chromatography/electrospray ionization tandem mass spectrometry and its application to cellular uptake experiment using human placental choriocarcinoma BeWo cells. ( 26343016 )
2015
13
Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells. ( 26299783 )
2015
14
Activation of endocrine-related gene expression in placental choriocarcinoma cell lines following DNA methylation knock-down. ( 24623739 )
2014
15
Role of protein kinase A in regulating steroid sulfate uptake for estrogen production in human placental choriocarcinoma cells. ( 24969759 )
2014
16
The impact of TGF-I^1 on the mRNA expression of TI^R I, TI^R II, Smad4 and the invasiveness of the JEG-3 placental choriocarcinoma cell line. ( 23205135 )
2012
17
Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell. ( 21993263 )
2011
18
Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization. ( 21455559 )
2011
19
Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERI^/MTA3/Snail/E-cadherin pathway. ( 22866146 )
2011
20
Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. ( 20736774 )
2010
21
Nitrofurantoin transport by placental choriocarcinoma JAr cells: involvement of BCRP, OATP2B1 and other MDR transporters. ( 19924425 )
2010
22
Expression of mTOR and downstream signalling components in the JEG-3 and BeWo human placental choriocarcinoma cell lines. ( 19956903 )
2010
23
Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. ( 19880178 )
2009
24
Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells. ( 19010540 )
2009
25
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. ( 18042733 )
2008
26
Incidental placental choriocarcinoma in a term pregnancy: a case report. ( 18922186 )
2008
27
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. ( 16632463 )
2006
28
Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling. ( 17026960 )
2006
29
Comparison of folic acid uptake characteristics by human placental choriocarcinoma cells at acidic and physiological pH. ( 16900951 )
2006
30
Induction of endogenous Nrf2/small maf heterodimers by arsenic-mediated stress in placental choriocarcinoma cells. ( 16487037 )
2006
31
Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. ( 16391323 )
2006
32
Insulin and leptin do not affect fatty acid uptake and metabolism in human placental choriocarcinoma (BeWo) cells. ( 15919610 )
2005
33
Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. ( 15316089 )
2005
34
Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine. ( 12657510 )
2003
35
Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. ( 12538089 )
2003
36
Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. ( 12175968 )
2002
37
Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells. ( 12445819 )
2002
38
Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells. ( 12050258 )
2002
39
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). ( 11334847 )
2001
40
Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line. ( 9528682 )
1998
41
Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. ( 9746226 )
1998
42
Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell proliferation and c-myc and growth factor expression in human placental choriocarcinoma JEG-3 cells. ( 9070231 )
1997
43
Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells: role of plasma membrane fatty acid-binding protein. ( 9458279 )
1997
44
Tyrosine phosphorylation-and epidermal growth factor-dependent regulation of the sodium-coupled amino acid transporter B0 in the human placental choriocarcinoma cell line JAR. ( 9194569 )
1997
45
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. ( 9290147 )
1997
46
Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. ( 8702519 )
1996
47
Sodium-dependent carnitine transport in human placental choriocarcinoma cells. ( 8865821 )
1996
48
JAR human placental choriocarcinoma cells actively synthesize, take up and release polyamines. ( 8888570 )
1996
49
Substrate-specific regulation of the taurine transporter in human placental choriocarcinoma cells (JAR). ( 7756345 )
1995
50
Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters. ( 8193164 )
1994

Variations for Placental Choriocarcinoma

Expression for Placental Choriocarcinoma

Search GEO for disease gene expression data for Placental Choriocarcinoma.

Pathways for Placental Choriocarcinoma

GO Terms for Placental Choriocarcinoma

Biological processes related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.5 ABCG2 PLIN2 SLC6A4
2 neurotransmitter transport GO:0006836 9.26 SLC22A2 SLC6A4
3 drug transmembrane transport GO:0006855 9.16 ABCG2 SLC22A2
4 neurotransmitter biosynthetic process GO:0042136 8.96 SLC22A2 SLC6A4
5 ammonium transmembrane transport GO:0072488 8.62 SLC22A2 SLC6A4

Sources for Placental Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....