MCID: PLC006
MIFTS: 26

Placental Choriocarcinoma malady

Cancer diseases category

Aliases & Classifications for Placental Choriocarcinoma

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Aliases & Descriptions for Placental Choriocarcinoma:

Name: Placental Choriocarcinoma 10 65
 
Choriocarcinoma of the Placenta 10


Classifications:



External Ids:

Disease Ontology10 DOID:2024
NCIt42 C8893

Summaries for Placental Choriocarcinoma

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MalaCards based summary: Placental Choriocarcinoma, also known as choriocarcinoma of the placenta, is related to choriocarcinoma and breast cancer. An important gene associated with Placental Choriocarcinoma is SLC19A1 (Solute Carrier Family 19 (Folate Transporter), Member 1), and among its related pathways are Methotrexate Pathway, Pharmacokinetics and Abacavir transport and metabolism. Affiliated tissues include placenta, brain and breast, and related mouse phenotypes are renal/urinary system and integument.

Related Diseases for Placental Choriocarcinoma

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Diseases related to Placental Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1choriocarcinoma11.0
2breast cancer10.1
3cholera10.1
4glioblastoma10.1
5dental fluorosis10.0LEP, SLC6A4
6eccrine adenocarcinoma10.0LEP, SLC6A4
7periventricular nodular heterotopia9.9LEP, PLIN1
8choriocarcinoma of ovary9.9ABCG2, GPC3, SLC19A1
9pica disease9.9LEP, SLC6A4
10fibrosarcoma of bone8.5ABCG2, DKK1, GPC3, LEP, MAF, MAFF

Graphical network of diseases related to Placental Choriocarcinoma:



Diseases related to placental choriocarcinoma

Symptoms for Placental Choriocarcinoma

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Drugs & Therapeutics for Placental Choriocarcinoma

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Drugs for Placental Choriocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Chorionic GonadotropinPhase 4164

Interventional clinical trials:

idNameStatusNCT IDPhase
1Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for ChoriocarcinomaNot yet recruitingNCT00294177Phase 4
2Second Curettage in Treating Patients With Persistent Non-Metastatic Gestational Trophoblastic TumorRecruitingNCT00521118Phase 2
3Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)Not yet recruitingNCT02664961Phase 2

Search NIH Clinical Center for Placental Choriocarcinoma

Genetic Tests for Placental Choriocarcinoma

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Anatomical Context for Placental Choriocarcinoma

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MalaCards organs/tissues related to Placental Choriocarcinoma:

33
Placenta, Brain, Breast

Animal Models for Placental Choriocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Placental Choriocarcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.6DKK1, GPC3, LEP, MAF, SLC19A1, SLC22A2
2MP:00107717.3ABCG2, GPC3, LEP, MAF, PLIN1, SLC19A1
3MP:00053766.4ABCG2, DKK1, GPC3, LEP, MAF, PLIN1

Publications for Placental Choriocarcinoma

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Articles related to Placental Choriocarcinoma:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells. (26299783)
2015
2
Activation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor gene expression following DNA demethylation in placental choriocarcinoma and transformed cell lines. (26014898)
2015
3
Quantification of new antiepileptic drugs by liquid chromatography/electrospray ionization tandem mass spectrometry and its application to cellular uptake experiment using human placental choriocarcinoma BeWo cells. (26343016)
2015
4
Activation of endocrine-related gene expression in placental choriocarcinoma cell lines following DNA methylation knock-down. (24623739)
2014
5
Role of protein kinase A in regulating steroid sulfate uptake for estrogen production in human placental choriocarcinoma cells. (24969759)
2014
6
The impact of TGF-I^1 on the mRNA expression of TI^R I, TI^R II, Smad4 and the invasiveness of the JEG-3 placental choriocarcinoma cell line. (23205135)
2012
7
Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell. (21993263)
2011
8
Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization. (21455559)
2011
9
Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERI^/MTA3/Snail/E-cadherin pathway. (22866146)
2011
10
Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. (20736774)
2010
11
Nitrofurantoin transport by placental choriocarcinoma JAr cells: involvement of BCRP, OATP2B1 and other MDR transporters. (19924425)
2010
12
Expression of mTOR and downstream signalling components in the JEG-3 and BeWo human placental choriocarcinoma cell lines. (19956903)
2010
13
Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells. (19010540)
2009
14
Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. (19880178)
2009
15
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. (18042733)
2008
16
Incidental placental choriocarcinoma in a term pregnancy: a case report. (18922186)
2008
17
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. (16632463)
2006
18
Induction of endogenous Nrf2/small maf heterodimers by arsenic-mediated stress in placental choriocarcinoma cells. (16487037)
2006
19
Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. (16391323)
2006
20
Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling. (17026960)
2006
21
Insulin and leptin do not affect fatty acid uptake and metabolism in human placental choriocarcinoma (BeWo) cells. (15919610)
2005
22
Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. (15316089)
2005
23
Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine. (12657510)
2003
24
Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. (12538089)
2003
25
Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells. (12445819)
2002
26
Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells. (12050258)
2002
27
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). (11334847)
2001
28
Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line. (9528682)
1998
29
Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. (9746226)
1998
30
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. (9290147)
1997
31
Tyrosine phosphorylation-and epidermal growth factor-dependent regulation of the sodium-coupled amino acid transporter B0 in the human placental choriocarcinoma cell line JAR. (9194569)
1997
32
Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells: role of plasma membrane fatty acid-binding protein. (9458279)
1997
33
Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell proliferation and c-myc and growth factor expression in human placental choriocarcinoma JEG-3 cells. (9070231)
1997
34
Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. (8702519)
1996
35
Sodium-dependent carnitine transport in human placental choriocarcinoma cells. (8865821)
1996
36
JAR human placental choriocarcinoma cells actively synthesize, take up and release polyamines. (8888570)
1996
37
Substrate-specific regulation of the taurine transporter in human placental choriocarcinoma cells (JAR). (7756345)
1995
38
Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters. (8193164)
1994
39
Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. (8182048)
1994
40
Functional characterization of L-alanine transport in a placental choriocarcinoma cell line (BeWo). (7886021)
1994
41
Characterization of the glycine transport system GLYT 1 in human placental choriocarcinoma cells (JAR). (8075134)
1994
42
Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. (8031869)
1994
43
Calmodulin-dependent modulation of pH sensitivity of the amino acid transport system L in human placental choriocarcinoma cells. (8018698)
1994
44
Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. (8408014)
1993
45
Modulation of the activity of amino acid transport system L by phorbol esters and calmodulin antagonists in a human placental choriocarcinoma cell line. (1324010)
1992
46
Transport of taurine and its regulation by protein kinase C in the JAR human placental choriocarcinoma cell line. (1854347)
1991
47
Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR). (1714897)
1991
48
Successful treatment of placental choriocarcinoma metastatic to brain followed by primary brain glioblastoma. (7060984)
1982
49
The prognostic application of HL-A and ABO typing in placental choriocarcinoma. (5377697)
1969
50
IMMUNOLOGICAL STUDIES IN PATIENTS WITH PLACENTAL CHORIOCARCINOMA. (14207839)
1964

Variations for Placental Choriocarcinoma

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Expression for genes affiliated with Placental Choriocarcinoma

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Search GEO for disease gene expression data for Placental Choriocarcinoma.

Pathways for genes affiliated with Placental Choriocarcinoma

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Pathways related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8ABCG2, SLC19A1
2
Show member pathways
9.8ABCG2, SLC22A2
39.8ABCG2, SLC22A2
49.4MAF, MAFF

GO Terms for genes affiliated with Placental Choriocarcinoma

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Biological processes related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1drug transmembrane transportGO:000685510.3ABCG2, SLC22A2
2cellular response to retinoic acidGO:007130010.3LEP, SLC6A4
3transmembrane transportGO:00550859.4ABCG2, SLC19A1, SLC22A2, SLC6A4
4small molecule metabolic processGO:00442818.4ABCG2, GPC3, PLIN1, SLC19A1, SLC22A2

Sources for Placental Choriocarcinoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet