MCID: PLC006
MIFTS: 35

Placental Choriocarcinoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Placental Choriocarcinoma

MalaCards integrated aliases for Placental Choriocarcinoma:

Name: Placental Choriocarcinoma 12 14 69
Choriocarcinoma of the Placenta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2024
NCIt 46 C8893
SNOMED-CT 64 448401007
UMLS 69 C0855173

Summaries for Placental Choriocarcinoma

MalaCards based summary : Placental Choriocarcinoma, also known as choriocarcinoma of the placenta, is related to choriocarcinoma and gestational choriocarcinoma. An important gene associated with Placental Choriocarcinoma is SLC19A1 (Solute Carrier Family 19 Member 1), and among its related pathways/superpathways are Selenium Micronutrient Network and Gefitinib Pathway, Pharmacokinetics. The drugs nivolumab and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and breast, and related phenotypes are homeostasis/metabolism and behavior/neurological

Related Diseases for Placental Choriocarcinoma

Graphical network of the top 20 diseases related to Placental Choriocarcinoma:



Diseases related to Placental Choriocarcinoma

Symptoms & Phenotypes for Placental Choriocarcinoma

MGI Mouse Phenotypes related to Placental Choriocarcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 PLIN2 SLC19A1 ABCG2 SLC22A2 SLC6A4 LEP
2 behavior/neurological MP:0005386 9.87 PLIN2 ABCG2 SLC6A4 LEP MAF MTHFD1
3 integument MP:0010771 9.7 PLIN2 SLC19A1 ABCG2 SLC6A4 LEP MAF
4 liver/biliary system MP:0005370 9.35 PLIN2 SLC19A1 ABCG2 LEP PLIN1
5 renal/urinary system MP:0005367 9.02 SLC19A1 SLC22A2 ABCG2 LEP MAF

Drugs & Therapeutics for Placental Choriocarcinoma

Drugs for Placental Choriocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies, Monoclonal Phase 2
3 Immunoglobulins Phase 2
4 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Placental Choriocarcinoma

Genetic Tests for Placental Choriocarcinoma

Anatomical Context for Placental Choriocarcinoma

MalaCards organs/tissues related to Placental Choriocarcinoma:

38
Placenta, Brain, Breast

Publications for Placental Choriocarcinoma

Articles related to Placental Choriocarcinoma:

(show top 50) (show all 64)
# Title Authors Year
1
Activation of Peroxisome Proliferator-Activated Receptor Gamma and Disruption of Progesterone Synthesis of 2-Ethylhexyl Diphenyl Phosphate in Human Placental Choriocarcinoma Cells: Comparison with Triphenyl Phosphate. ( 28282128 )
2017
2
Myricetin suppresses invasion and promotes cell death in human placental choriocarcinoma cells through induction of oxidative stress. ( 28428076 )
2017
3
Fatty acid-binding protein3 expression in BeWo cells, a human placental choriocarcinoma cell line. ( 28515017 )
2017
4
Treatment of Human Placental Choriocarcinoma Cells with Formaldehyde and Benzene Induced Growth and Epithelial Mesenchymal Transition via Induction of an Antioxidant Effect. ( 28758930 )
2017
5
Coumestrol induces mitochondrial dysfunction by stimulating ROS production and calcium ion influx into mitochondria in human placental choriocarcinoma cells. ( 29040664 )
2017
6
Evaluation of the effects of antiepileptic drugs on folic acid uptake by human placental choriocarcinoma cells. ( 29223574 )
2017
7
Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. ( 26917260 )
2016
8
Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways. ( 27580989 )
2016
9
Corrigendum to "Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (Bewo) cells" [Placenta (2009) 1037-1044]. ( 27623544 )
2016
10
Involvement of l-type amino acid transporter 1 in the transport of gabapentin into human placental choriocarcinoma cells. ( 27818298 )
2016
11
Luteolin Inhibits Proliferation and Induces Apoptosis of Human Placental Choriocarcinoma Cells by Blocking the PI3K/AKT Pathway and Regulating Sterol Regulatory Element Binding Protein Activity. ( 27580988 )
2016
12
Green tea (-)-epigallocatechin gallate induced growth inhibition of human placental choriocarcinoma cells. ( 27208402 )
2016
13
Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells. ( 26299783 )
2015
14
Activation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor gene expression following DNA demethylation in placental choriocarcinoma and transformed cell lines. ( 26014898 )
2015
15
Quantification of new antiepileptic drugs by liquid chromatography/electrospray ionization tandem mass spectrometry and its application to cellular uptake experiment using human placental choriocarcinoma BeWo cells. ( 26343016 )
2015
16
Role of protein kinase A in regulating steroid sulfate uptake for estrogen production in human placental choriocarcinoma cells. ( 24969759 )
2014
17
Activation of endocrine-related gene expression in placental choriocarcinoma cell lines following DNA methylation knock-down. ( 24623739 )
2014
18
The impact of TGF-I^1 on the mRNA expression of TI^R I, TI^R II, Smad4 and the invasiveness of the JEG-3 placental choriocarcinoma cell line. ( 23205135 )
2012
19
Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERI^/MTA3/Snail/E-cadherin pathway. ( 22866146 )
2011
20
Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization. ( 21455559 )
2011
21
Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell. ( 21993263 )
2011
22
Expression of mTOR and downstream signalling components in the JEG-3 and BeWo human placental choriocarcinoma cell lines. ( 19956903 )
2010
23
Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. ( 20736774 )
2010
24
Nitrofurantoin transport by placental choriocarcinoma JAr cells: involvement of BCRP, OATP2B1 and other MDR transporters. ( 19924425 )
2010
25
Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. ( 19880178 )
2009
26
Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells. ( 19010540 )
2009
27
Incidental placental choriocarcinoma in a term pregnancy: a case report. ( 18922186 )
2008
28
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. ( 18042733 )
2008
29
Induction of endogenous Nrf2/small maf heterodimers by arsenic-mediated stress in placental choriocarcinoma cells. ( 16487037 )
2006
30
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. ( 16632463 )
2006
31
Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling. ( 17026960 )
2006
32
Comparison of folic acid uptake characteristics by human placental choriocarcinoma cells at acidic and physiological pH. ( 16900951 )
2006
33
Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. ( 16391323 )
2006
34
Insulin and leptin do not affect fatty acid uptake and metabolism in human placental choriocarcinoma (BeWo) cells. ( 15919610 )
2005
35
Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. ( 15316089 )
2005
36
Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. ( 12538089 )
2003
37
Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine. ( 12657510 )
2003
38
Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells. ( 12445819 )
2002
39
Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. ( 12175968 )
2002
40
Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells. ( 12050258 )
2002
41
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). ( 11334847 )
2001
42
Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line. ( 9528682 )
1998
43
Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. ( 9746226 )
1998
44
Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell proliferation and c-myc and growth factor expression in human placental choriocarcinoma JEG-3 cells. ( 9070231 )
1997
45
Tyrosine phosphorylation-and epidermal growth factor-dependent regulation of the sodium-coupled amino acid transporter B0 in the human placental choriocarcinoma cell line JAR. ( 9194569 )
1997
46
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. ( 9290147 )
1997
47
Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells: role of plasma membrane fatty acid-binding protein. ( 9458279 )
1997
48
Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. ( 8702519 )
1996
49
JAR human placental choriocarcinoma cells actively synthesize, take up and release polyamines. ( 8888570 )
1996
50
Sodium-dependent carnitine transport in human placental choriocarcinoma cells. ( 8865821 )
1996

Variations for Placental Choriocarcinoma

Expression for Placental Choriocarcinoma

Search GEO for disease gene expression data for Placental Choriocarcinoma.

Pathways for Placental Choriocarcinoma

Pathways related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.94 MTHFD1 MTR SLC19A1
2
Show member pathways
11.27 ABCG2 SLC22A2
3 11.25 LEP PLIN1 PLIN2
4 11.1 MAF MAFF
5 10.9 ABCG2 SLC19A1
6
Show member pathways
10.78 SLC22A2 SLC6A4
7
Show member pathways
10.62 ABCG2 SLC22A2
8 10.61 ABCG2 LEP PLIN2
9
Show member pathways
10.56 ABCG2 SLC19A1
10 10.41 ABCG2 SLC22A2

GO Terms for Placental Choriocarcinoma

Biological processes related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.61 ABCG2 PLIN2 SLC6A4
2 neurotransmitter transport GO:0006836 9.4 SLC22A2 SLC6A4
3 cellular amino acid biosynthetic process GO:0008652 9.37 MTHFD1 MTR
4 drug transmembrane transport GO:0006855 9.32 ABCG2 SLC22A2
5 folic acid metabolic process GO:0046655 9.26 MTHFD1 SLC19A1
6 neurotransmitter biosynthetic process GO:0042136 9.16 SLC22A2 SLC6A4
7 ammonium transmembrane transport GO:0072488 8.96 SLC22A2 SLC6A4
8 methionine biosynthetic process GO:0009086 8.62 MTHFD1 MTR

Sources for Placental Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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