MCID: PLC006
MIFTS: 34

Placental Choriocarcinoma malady

Categories: Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Placental Choriocarcinoma

Aliases & Descriptions for Placental Choriocarcinoma:

Name: Placental Choriocarcinoma 12 14 69
Choriocarcinoma of the Placenta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2024
NCIt 47 C8893
SNOMED-CT 64 448401007
UMLS 69 C0855173

Summaries for Placental Choriocarcinoma

MalaCards based summary : Placental Choriocarcinoma, also known as choriocarcinoma of the placenta, is related to choriocarcinoma and anodontia. An important gene associated with Placental Choriocarcinoma is SLC19A1 (Solute Carrier Family 19 Member 1), and among its related pathways/superpathways are Folate Metabolism and Adipogenesis. The drugs Chorionic Gonadotropin and Nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and breast, and related phenotypes are homeostasis/metabolism and integument

Related Diseases for Placental Choriocarcinoma

Graphical network of the top 20 diseases related to Placental Choriocarcinoma:



Diseases related to Placental Choriocarcinoma

Symptoms & Phenotypes for Placental Choriocarcinoma

MGI Mouse Phenotypes related to Placental Choriocarcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 ABCG2 LEP MAF MTHFD1 MTR PLIN1
2 integument MP:0010771 9.7 ABCG2 LEP MAF PLIN1 PLIN2 SLC19A1
3 liver/biliary system MP:0005370 9.35 ABCG2 LEP PLIN1 PLIN2 SLC19A1
4 renal/urinary system MP:0005367 9.02 ABCG2 LEP MAF SLC19A1 SLC22A2

Drugs & Therapeutics for Placental Choriocarcinoma

Drugs for Placental Choriocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Chorionic Gonadotropin Phase 4
2
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
nivolumab Approved Phase 2 946414-94-4
5 Angiogenesis Inhibitors Phase 2
6 Angiogenesis Modulating Agents Phase 2
7 Immunoglobulins Phase 2
8 Antibodies, Monoclonal Phase 2
9 Antibodies Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177 Phase 4
2 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
3 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
4 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2
5 The French National Reference Centre of GTD Recruiting NCT02892877

Search NIH Clinical Center for Placental Choriocarcinoma

Genetic Tests for Placental Choriocarcinoma

Anatomical Context for Placental Choriocarcinoma

MalaCards organs/tissues related to Placental Choriocarcinoma:

39
Placenta, Brain, Breast

Publications for Placental Choriocarcinoma

Articles related to Placental Choriocarcinoma:

(show top 50) (show all 58)
id Title Authors Year
1
Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. ( 26917260 )
2016
2
Corrigendum to "Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (Bewo) cells" [Placenta (2009) 1037-1044]. ( 27623544 )
2016
3
Green tea (-)-epigallocatechin gallate induced growth inhibition of human placental choriocarcinoma cells. ( 27208402 )
2016
4
Involvement of l-type amino acid transporter 1 in the transport of gabapentin into human placental choriocarcinoma cells. ( 27818298 )
2016
5
Luteolin Inhibits Proliferation and Induces Apoptosis of Human Placental Choriocarcinoma Cells by Blocking the PI3K/AKT Pathway and Regulating Sterol Regulatory Element Binding Protein Activity. ( 27580988 )
2016
6
Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways. ( 27580989 )
2016
7
Quantification of new antiepileptic drugs by liquid chromatography/electrospray ionization tandem mass spectrometry and its application to cellular uptake experiment using human placental choriocarcinoma BeWo cells. ( 26343016 )
2015
8
Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells. ( 26299783 )
2015
9
Activation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor gene expression following DNA demethylation in placental choriocarcinoma and transformed cell lines. ( 26014898 )
2015
10
Role of protein kinase A in regulating steroid sulfate uptake for estrogen production in human placental choriocarcinoma cells. ( 24969759 )
2014
11
Activation of endocrine-related gene expression in placental choriocarcinoma cell lines following DNA methylation knock-down. ( 24623739 )
2014
12
The impact of TGF-I^1 on the mRNA expression of TI^R I, TI^R II, Smad4 and the invasiveness of the JEG-3 placental choriocarcinoma cell line. ( 23205135 )
2012
13
Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell. ( 21993263 )
2011
14
Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERI^/MTA3/Snail/E-cadherin pathway. ( 22866146 )
2011
15
Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization. ( 21455559 )
2011
16
Expression of mTOR and downstream signalling components in the JEG-3 and BeWo human placental choriocarcinoma cell lines. ( 19956903 )
2010
17
Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. ( 20736774 )
2010
18
Nitrofurantoin transport by placental choriocarcinoma JAr cells: involvement of BCRP, OATP2B1 and other MDR transporters. ( 19924425 )
2010
19
Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. ( 19880178 )
2009
20
Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells. ( 19010540 )
2009
21
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. ( 18042733 )
2008
22
Incidental placental choriocarcinoma in a term pregnancy: a case report. ( 18922186 )
2008
23
Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. ( 16391323 )
2006
24
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. ( 16632463 )
2006
25
Comparison of folic acid uptake characteristics by human placental choriocarcinoma cells at acidic and physiological pH. ( 16900951 )
2006
26
Induction of endogenous Nrf2/small maf heterodimers by arsenic-mediated stress in placental choriocarcinoma cells. ( 16487037 )
2006
27
Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling. ( 17026960 )
2006
28
Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. ( 15316089 )
2005
29
Insulin and leptin do not affect fatty acid uptake and metabolism in human placental choriocarcinoma (BeWo) cells. ( 15919610 )
2005
30
Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. ( 12538089 )
2003
31
Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine. ( 12657510 )
2003
32
Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells. ( 12050258 )
2002
33
Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. ( 12175968 )
2002
34
Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells. ( 12445819 )
2002
35
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). ( 11334847 )
2001
36
Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line. ( 9528682 )
1998
37
Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. ( 9746226 )
1998
38
Tyrosine phosphorylation-and epidermal growth factor-dependent regulation of the sodium-coupled amino acid transporter B0 in the human placental choriocarcinoma cell line JAR. ( 9194569 )
1997
39
Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells: role of plasma membrane fatty acid-binding protein. ( 9458279 )
1997
40
Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell proliferation and c-myc and growth factor expression in human placental choriocarcinoma JEG-3 cells. ( 9070231 )
1997
41
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. ( 9290147 )
1997
42
Sodium-dependent carnitine transport in human placental choriocarcinoma cells. ( 8865821 )
1996
43
Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. ( 8702519 )
1996
44
JAR human placental choriocarcinoma cells actively synthesize, take up and release polyamines. ( 8888570 )
1996
45
Substrate-specific regulation of the taurine transporter in human placental choriocarcinoma cells (JAR). ( 7756345 )
1995
46
Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. ( 8031869 )
1994
47
Characterization of the glycine transport system GLYT 1 in human placental choriocarcinoma cells (JAR). ( 8075134 )
1994
48
Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters. ( 8193164 )
1994
49
Calmodulin-dependent modulation of pH sensitivity of the amino acid transport system L in human placental choriocarcinoma cells. ( 8018698 )
1994
50
Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. ( 8182048 )
1994

Variations for Placental Choriocarcinoma

Expression for Placental Choriocarcinoma

Search GEO for disease gene expression data for Placental Choriocarcinoma.

Pathways for Placental Choriocarcinoma

GO Terms for Placental Choriocarcinoma

Biological processes related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.61 ABCG2 PLIN2 SLC6A4
2 neurotransmitter transport GO:0006836 9.4 SLC22A2 SLC6A4
3 cellular amino acid biosynthetic process GO:0008652 9.37 MTHFD1 MTR
4 drug transmembrane transport GO:0006855 9.32 ABCG2 SLC22A2
5 folic acid metabolic process GO:0046655 9.26 MTHFD1 SLC19A1
6 neurotransmitter biosynthetic process GO:0042136 9.16 SLC22A2 SLC6A4
7 ammonium transmembrane transport GO:0072488 8.96 SLC22A2 SLC6A4
8 methionine biosynthetic process GO:0009086 8.62 MTHFD1 MTR

Sources for Placental Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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