PSST
MCID: PLC003
MIFTS: 47

Placental Site Trophoblastic Tumor (PSST) malady

Categories: Rare diseases, Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Placental Site Trophoblastic Tumor

Aliases & Descriptions for Placental Site Trophoblastic Tumor:

Name: Placental Site Trophoblastic Tumor 12 56 14
Trophoblastic Tumor, Placental Site 42 69
Trophoblastic Tumor Placental Site 50 52
Placental-Site Gestational Trophoblastic Neoplasm 12
Placenta Neoplasm 50
Deciduoma 69
Psst 56

Characteristics:

Orphanet epidemiological data:

56
placental site trophoblastic tumor
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:3596
MeSH 42 D018245
NCIt 47 C3757
SNOMED-CT 64 237252008 75320001
Orphanet 56 ORPHA99928
MESH via Orphanet 43 D018245
ICD10 via Orphanet 34 D39.2
UMLS via Orphanet 70 C0206666
ICD10 33 C58
UMLS 69 C0206666

Summaries for Placental Site Trophoblastic Tumor

MalaCards based summary : Placental Site Trophoblastic Tumor, also known as trophoblastic tumor, placental site, is related to choriocarcinoma and liddle syndrome, scnn1g-related, and has symptoms including metrorrhagia, amenorrhea and spontaneous abortion. An important gene associated with Placental Site Trophoblastic Tumor is INHA (Inhibin Alpha Subunit), and among its related pathways/superpathways are PI3K-Akt signaling pathway and MicroRNAs in cancer. The drugs Chorionic Gonadotropin and Nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and lung, and related phenotypes are Decreased viability with paclitaxel and cardiovascular system

Wikipedia : 71 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

Related Diseases for Placental Site Trophoblastic Tumor

Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
id Related Disease Score Top Affiliating Genes
1 choriocarcinoma 10.2
2 liddle syndrome, scnn1g-related 10.2 EGFR VEGFA
3 mucinous cystadenocarcinoma 10.2 CSH1 INHA
4 spastic paraplegia 1 10.1 EGFR VEGFA
5 pineal region mature teratoma 10.1 EGFR ERBB2
6 novak syndrome 10.1 CGB5 ERBB2
7 triple-receptor negative breast cancer 10.1 EGFR ERBB2
8 tumor of exocrine pancreas 10.1 EGFR VEGFA
9 skin sarcoma 10.1 EGFR ERBB2
10 cervical lymphoepithelioma-like carcinoma 10.1 EGFR ERBB2
11 epithelioid trophoblastic tumor 10.1
12 benign familial neonatal epilepsy 10.1 EGFR VEGFA
13 nervous system hibernoma 10.1 EGFR ERBB2
14 basaloid squamous cell carcinoma 10.1 EGFR ERBB2
15 combined t cell and b cell immunodeficiency 10.1 EGFR ERBB2
16 anomalous left coronary artery from the pulmonary artery 10.1 EGFR ERBB2
17 reactive arthritis 10.1 EGFR ERBB2
18 prostate signet ring cell adenocarcinoma 10.1 EGFR ERBB2
19 growth retardation hydrocephaly lung hypoplasia 10.1 ERBB2 INHA
20 anus adenocarcinoma 10.1 EGFR ERBB2
21 teratoma 10.1
22 spongiotic dermatitis 10.1 EGFR ERBB2
23 sclerosing hemangioma 10.1 EGFR ERBB2
24 vascular hemostatic disease 10.0 EGFR ERBB2
25 anaerobic meningitis 10.0 EGFR VEGFA
26 retinal disease 10.0 EGFR ERBB2
27 spastic diplegia infantile type 10.0 EGFR ERBB2
28 gestational trophoblastic neoplasm 10.0
29 trophoblastic neoplasm 10.0
30 fallopian tube carcinosarcoma 10.0 ERBB2 VEGFA
31 leigh syndrome 10.0
32 ectopic pregnancy 10.0
33 leiomyoma 10.0
34 vaginitis 10.0
35 cervicitis 10.0
36 his bundle tachycardia 10.0 EGFR ERBB2
37 estrogen-receptor positive breast cancer 10.0 EGFR ERBB2
38 immunodeficiency due to a late component of complement deficiency 9.9 EGFR ERBB2 VEGFA
39 multinodular goiter 9.9 EGFR ERBB2 VEGFA
40 dental caries 9.9 EGFR ERBB2 VEGFA
41 nasal cavity disease 9.9 EGFR ERBB2 VEGFA
42 uvula cancer 9.9 EGFR ERBB2 VEGFA
43 pearson syndrome 9.9 EGFR ERBB2 VEGFA
44 trachea squamous cell carcinoma 9.9 EGFR ERBB2 VEGFA
45 pulmonary fibrosis and/or bone marrow failure, telomere-related, 1 9.9 EGFR ERBB2 VEGFA
46 bardet-biedl syndrome 9.9 EGFR ERBB2 VEGFA
47 malignant pleural solitary fibrous tumor 9.9 EGFR ERBB2 VEGFA
48 nevoid hypermelanosis, linear and whorled 9.9 EGFR ERBB2 VEGFA
49 placenta praevia 9.9 EGFR ERBB2 VEGFA
50 glucose-6-phosphate translocase deficiency 9.9 EGFR ERBB2 VEGFA

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to Placental Site Trophoblastic Tumor

Symptoms & Phenotypes for Placental Site Trophoblastic Tumor

Human phenotypes related to Placental Site Trophoblastic Tumor:

56 32
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 metrorrhagia 56 32 Very frequent (99-80%) HP:0100608
2 amenorrhea 56 32 Very frequent (99-80%) HP:0000141
3 spontaneous abortion 56 32 Very frequent (99-80%) HP:0005268
4 low maternal serum chorionic gonadotropin 56 32 Very frequent (99-80%) HP:0011434

GenomeRNAi Phenotypes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.8 EGFR ERBB2
2 Decreased viability with paclitaxel GR00179-A-3 8.8 EGFR

MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 EGFR ERBB2 GPC3 INHA LNPEP VEGFA
2 digestive/alimentary MP:0005381 9.02 EGFR ERBB2 GPC3 INHA VEGFA

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

Drugs for Placental Site Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Chorionic Gonadotropin Phase 4
2
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
nivolumab Approved Phase 2 946414-94-4
5 Angiogenesis Inhibitors Phase 2
6 Angiogenesis Modulating Agents Phase 2
7 Immunoglobulins Phase 2
8 Antibodies, Monoclonal Phase 2
9 Antibodies Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177 Phase 4
2 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
3 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2
4 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
5 The French National Reference Centre of GTD Recruiting NCT02892877

Search NIH Clinical Center for Placental Site Trophoblastic Tumor

Cochrane evidence based reviews: trophoblastic tumor, placental site

Genetic Tests for Placental Site Trophoblastic Tumor

Anatomical Context for Placental Site Trophoblastic Tumor

MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

39
Placenta, Uterus, Lung, Ovary, Brain, Cervix, Testis

Publications for Placental Site Trophoblastic Tumor

Articles related to Placental Site Trophoblastic Tumor:

(show top 50) (show all 166)
id Title Authors Year
1
SALL4 expression in gestational trophoblastic tumors: a useful tool to distinguish choriocarcinoma from placental site trophoblastic tumor and epithelioid trophoblastic tumor. ( 27068524 )
2016
2
Placental site trophoblastic tumor: A review of 108 cases and their implications for prognosis and treatment. ( 27168005 )
2016
3
Diagnosis and management of a rare case with placental site trophoblastic tumor. ( 27751424 )
2016
4
Imaging and Clinical Data of Placental Site Trophoblastic Tumor: A Case Report. ( 27679689 )
2016
5
Extrauterine Placental Site Trophoblastic Tumor Involving the Vagina. ( 27513078 )
2016
6
Placental site trophoblastic tumor and choriocarcinoma: an unusual presentation. ( 26597227 )
2015
7
Placental site trophoblastic tumor: report of a tertiary center experience. ( 26775357 )
2015
8
Placental site trophoblastic tumor: a case report and review of the literature. ( 26622924 )
2015
9
Placental site trophoblastic tumor: A case report and literature review. ( 26361566 )
2015
10
Retrospective analysis of the clinicopathologic and prognostic characteristics of stage I placental site trophoblastic tumor in China. ( 25572983 )
2015
11
Placental site trophoblastic tumor presented with vaginal metastasis. ( 25932270 )
2015
12
Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. ( 26261623 )
2015
13
Placental-site trophoblastic tumor and fluorine-18- fluorodeoxyglucose positron emission tomography/ computed tomography. ( 26574698 )
2015
14
Single synchronous pulmonary metastasis from placental site trophoblastic tumor and teratoma. ( 25908040 )
2015
15
Attempted conservative management of a placental site trophoblastic tumor: a case report. ( 25314886 )
2014
16
Exaggerated placental site/placental site trophoblastic tumor: an underestimated risk factor for emergency peripartum hysterectomy. ( 25551954 )
2014
17
Placental site trophoblastic tumor: Immunohistochemistry algorithm key to diagnosis and review of literature. ( 24624322 )
2014
18
Placental site trophoblastic tumor: a case report and review of the literature. ( 25593955 )
2014
19
Lupus nephritis associated with placental site trophoblastic tumor: A case report and review of the literature. ( 24944882 )
2014
20
Placental site trophoblastic tumor on endometrial polyp: a case report. ( 24654471 )
2014
21
Sonographic characteristics of placental site trophoblastic tumor. ( 22807194 )
2013
22
Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report. ( 23688193 )
2013
23
Placental site trophoblastic tumor in the pelvic wall: a case report and review of the literature. ( 24152517 )
2013
24
Unsuccessful planned conservative resection of placental site trophoblastic tumor. ( 23344410 )
2013
25
Placental site trophoblastic tumor, report of a case with unusual presentation. ( 23478075 )
2013
26
Placental site trophoblastic tumor with metastasis - A case report. ( 24532939 )
2013
27
Diagnosis and treatment of placental site trophoblastic tumor. ( 23826431 )
2013
28
Atypical recurrence of a placental site trophoblastic tumor four years after hysterectomy for benign condition: Case report and review of literature. ( 24371716 )
2013
29
Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome. ( 23274560 )
2013
30
Long-term outcome of placental site trophoblastic tumor in The Netherlands. ( 23763007 )
2013
31
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. ( 23040933 )
2012
32
Placental Site Trophoblastic Tumor with lung metastases as cause of death in a young patient: a case report. ( 22027660 )
2011
33
Two cases of placental site trophoblastic tumor. ( 22030056 )
2011
34
Clinical features of 17 cases of placental site trophoblastic tumor. ( 21862010 )
2011
35
Kidney involvement in a patient affected by placental site trophoblastic tumor. ( 21257242 )
2011
36
Placental site trophoblastic tumor: lymphatic spread and possible target markers. ( 19910023 )
2010
37
Placental site trophoblastic tumor--a challenging, rare entity. ( 21199764 )
2010
38
Placental site trophoblastic tumor with unusual presentation in the uterine cervix. ( 19819607 )
2010
39
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. ( 20381116 )
2010
40
Expression of glypican 3 in placental site trophoblastic tumor. ( 20868507 )
2010
41
Exaggerated placental site mimicking placental site trophoblastic tumor: case report and literature review. ( 21061810 )
2010
42
Placental site trophoblastic tumor presenting as a friable cervical mass. ( 21061804 )
2010
43
Diagnostic evaluation of metastatic placental site trophoblastic tumor. ( 19622963 )
2009
44
Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. ( 19366068 )
2009
45
Placental site trophoblastic tumor. ( 19935163 )
2009
46
Placental site trophoblastic tumor with multiple metastases and complete response to salvage BEP regimen: a case report and review of the literature. ( 18506643 )
2009
47
Placental site trophoblastic tumor (PSTT) with multiple metastases and extremely poor prognosis. ( 19856056 )
2009
48
Survival of placental-site trophoblastic tumor patients strongly linked with time since related pregnancy. ( 19670504 )
2009
49
Placental site trophoblastic tumor diagnosed on transvaginal sonography. ( 19644948 )
2009
50
Placental site trophoblastic tumor in the ovary of a young child with isosexual precocious puberty. ( 18671454 )
2009

Variations for Placental Site Trophoblastic Tumor

Expression for Placental Site Trophoblastic Tumor

Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for Placental Site Trophoblastic Tumor

Pathways related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1 12.25 CSH1 EGFR VEGFA
2 12.15 EGFR ERBB2 VEGFA
3
Show member pathways
12.12 EGFR ERBB2 GPC3
4
Show member pathways
11.64 EGFR ERBB2 VEGFA
5 11.56 EGFR ERBB2 GPC3 VEGFA
6 11.43 EGFR ERBB2 VEGFA
7 11.27 EGFR ERBB2
8 11.2 EGFR ERBB2 VEGFA
9 11.19 EGFR VEGFA
10 11.11 EGFR ERBB2
11
Show member pathways
11.06 EGFR VEGFA
12 10.9 EGFR ERBB2
13
Show member pathways
10.89 CGB5 EGFR ERBB2 VEGFA
14 10.85 EGFR ERBB2

GO Terms for Placental Site Trophoblastic Tumor

Cellular components related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 CGB5 CSH1 EGFR GPC3 INHA LNPEP

Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.7 CGB5 INHA LNPEP
2 regulation of transcription from RNA polymerase II promoter GO:0006357 9.67 CGB5 EGFR ERBB2 VEGFA
3 cell surface receptor signaling pathway GO:0007166 9.65 EGFR ERBB2 INHA
4 cellular response to growth factor stimulus GO:0071363 9.55 EGFR ERBB2
5 positive regulation of cell adhesion GO:0045785 9.54 ERBB2 VEGFA
6 ovarian follicle development GO:0001541 9.51 INHA VEGFA
7 positive regulation of protein phosphorylation GO:0001934 9.5 EGFR ERBB2 VEGFA
8 cellular response to epidermal growth factor stimulus GO:0071364 9.49 EGFR ERBB2
9 ERBB2 signaling pathway GO:0038128 9.46 EGFR ERBB2
10 regulation of cell motility GO:2000145 9.43 EGFR ERBB2
11 regulation of ERK1 and ERK2 cascade GO:0070372 9.4 EGFR ERBB2
12 lung development GO:0030324 9.33 EGFR GPC3 VEGFA
13 negative regulation of ERBB signaling pathway GO:1901185 9.26 EGFR ERBB2
14 positive regulation of epithelial cell proliferation GO:0050679 9.13 EGFR ERBB2 VEGFA
15 positive regulation of MAP kinase activity GO:0043406 8.8 EGFR ERBB2 VEGFA

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.26 EGFR ERBB2 INHA VEGFA
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 EGFR ERBB2
3 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.62 EGFR ERBB2

Sources for Placental Site Trophoblastic Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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