PSST
MCID: PLC003
MIFTS: 59

Placental Site Trophoblastic Tumor (PSST) malady

Rare diseases, Cancer diseases, Reproductive diseases categories
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Summaries for Placental Site Trophoblastic Tumor

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Wikipedia:65 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards based summary: Placental Site Trophoblastic Tumor, also known as placental-site gestational trophoblastic neoplasm, is related to epithelioid trophoblastic tumor and trophoblastic neoplasm, and has symptoms including metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea, neoplasms/tumors and uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer. An important gene associated with Placental Site Trophoblastic Tumor is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Alzheimers Disease Pathway and Agrin Interactions at Neuromuscular Junction. The compounds griseofulvin and 11-ketotestosterone have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and uterus, and related mouse phenotypes are reproductive system and embryogenesis.

Aliases & Classifications for Placental Site Trophoblastic Tumor

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 62UMLS, 42NIH Rare Diseases, 44Novoseek, 57SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Placental Site Trophoblastic Tumor, Aliases & Descriptions:

Name: Placental Site Trophoblastic Tumor 8 10 48
Placental-Site Gestational Trophoblastic Neoplasm 8 62
Trophoblastic Tumor Placental Site 42 44
Trophoblastic Tumor, Placental Site 62
 
Neoplasm of Placenta 62
Placenta Neoplasm 42
Psst 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

48
placental site trophoblastic tumor:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:3596
MeSH34 D018245
NCIt39 C3757
MESH via Orphanet35 D018245
SNOMED-CT57 75320001, 237252008
ICD10 via Orphanet26 D39.2
UMLS via Orphanet63 C0206666
ICD1025 C58

Related Diseases for Placental Site Trophoblastic Tumor

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Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid trophoblastic tumor31.5MCAM
2trophoblastic neoplasm31.2CGA, CGB5
3ectopic pregnancy31.0CGB, CGA, CGB5
4precocious puberty30.9CGA, CGB5
5gestational trophoblastic neoplasm30.7ALPP, CGB, CGA, CGB5
6teratoma30.4CGA, CGB5, CGB, ALPP, GPC3
7choriocarcinoma30.3KRT18, CGB, CGB5, ALPP, GPC3, CGA
8extragonadal germ cell tumor10.5CGB5
9superior vena cava syndrome10.5CGB
10cervicitis10.5
11leiomyoma10.5
12germ cell tumors10.5
13anencephaly10.5CGA
14cryptococcosis10.3CGB, CGB5
15alopecia10.3
16arteriovenous fistula10.3
17placental abruption10.3
18infertility10.3
19placenta accreta10.3
20alopecia areata10.3
21pneumothorax10.3
22proteinuria10.3
23vaginitis10.3
24lupus nephritis10.3
25nonseminomatous germ cell tumor10.3
26erythrocytosis10.3
27testicular germ cell tumor10.3
28nephritis10.3
29invasive mole10.3
30ovarian cyst10.3CGB5, CGA
31ovarian hyperstimulation syndrome10.3CGA, CGB5
32gynecomastia10.3CGB5, CGA
33oligospermia10.3CGA, CGB5
34germ cell cancer10.3ALPP, CGA
35kallmann syndrome10.3CGA, CGB5
36turner syndrome10.3CGA, CGB
37polycystic ovary syndrome10.3CGA, CGB5
38leydig cell tumor10.2CGB5, CGA
39thymus cancer10.2ALPP, KRT18
40klinefelter's syndrome10.2CGA, CGB
41hyperandrogenism10.2CGA, CGB5
42endodermal sinus tumor10.2CGB5, CGB, ALPP
43gestational trophoblastic tumor10.2CGA, CGB, CGB5
44hyperprolactinemia10.2CGB5, CGA, CGB
45pregnancy loss10.2CGB5, CGA, CGB
46neural tube defects10.2CGB, CGA, CGB5
47deficiency anemia10.2ALPP, CGB, CGB5
48down syndrome10.2CGB5, CGB, CGA
49dysgerminoma10.2ALPP, CGA, CGB5
50cryptorchidism10.2CGB5, ALPP, CGA

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Symptoms for Placental Site Trophoblastic Tumor

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Symptoms:

48 (show all 9)
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • neoplasms/tumors
  • uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer
  • antenatal period/pregnancy anomalies
  • spontaneous abortions
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Placental Site Trophoblastic Tumor:

(show all 7)
id Description Frequency HPO Source Accession
1 abnormality of the menstrual cycle hallmark (90%) HP:0000140
2 spontaneous abortion hallmark (90%) HP:0005268
3 uterine neoplasm hallmark (90%) HP:0010784
4 neoplasm of the liver occasional (7.5%) HP:0002896
5 neoplasm of the nervous system occasional (7.5%) HP:0004375
6 neoplasm of the lung occasional (7.5%) HP:0100526
7 vaginal neoplasm occasional (7.5%) HP:0100650

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

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Drug clinical trials:

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Search NIH Clinical Center for Placental Site Trophoblastic Tumor

Genetic Tests for Placental Site Trophoblastic Tumor

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Anatomical Context for Placental Site Trophoblastic Tumor

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MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

32
Placenta, Lung, Uterus, Cervix, Liver, Ovary, Brain, Testis, Lymph node, Kidney, Adrenal gland, Testes

Animal Models for Placental Site Trophoblastic Tumor or affiliated genes

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MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2CGA, EGFR, ERBB2, ALPP, GPC3
2MP:00053808.1EGFR, KRT18, ERBB2, ALPP, GPC3
3MP:00053787.5GPC3, ALPP, ERBB2, KRT18, EGFR, CGA

Publications for Placental Site Trophoblastic Tumor

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Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 150)
idTitleAuthorsYear
1
Lupus nephritis associated with placental site trophoblastic tumor: A case report and review of the literature. (24944882)
2014
2
Unsuccessful planned conservative resection of placental site trophoblastic tumor. (23344410)
2013
3
Diagnosis and treatment of placental site trophoblastic tumor. (23826431)
2013
4
Placental site trophoblastic tumor, report of a case with unusual presentation. (23478075)
2013
5
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. (23040933)
2012
6
Clinical features of 17 cases of placental site trophoblastic tumor. (21862010)
2011
7
Kidney involvement in a patient affected by placental site trophoblastic tumor. (21257242)
2011
8
Two cases of placental site trophoblastic tumor. (22030056)
2011
9
Placental site trophoblastic tumor--a challenging, rare entity. (21199764)
2010
10
Placental site trophoblastic tumor presenting as a friable cervical mass. (21061804)
2010
11
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. (20381116)
2010
12
Placental site trophoblastic tumor: lymphatic spread and possible target markers. (19910023)
2010
13
Placental site trophoblastic tumor. (19935163)
2009
14
Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. (19366068)
2009
15
Survival of placental-site trophoblastic tumor patients strongly linked with time since related pregnancy. (19670504)
2009
16
Placental-site trophoblastic tumors: a case of resistant pulmonary metastasis. (18227827)
2008
17
Absence of Y chromosome in human placental site trophoblastic tumor. (17643092)
2007
18
Fertility sparing therapy in a patient with placental site trophoblastic tumor: a case report. (17007914)
2006
19
Exclusion of lung metastases in placental site trophoblastic tumor using [18F]fluorodeoxyglucose positron emission tomography: a case report. (16051337)
2005
20
Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature. (15958158)
2005
21
Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor. (16127165)
2005
22
p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. (15316317)
2004
23
Placental site trophoblastic tumor in a postmenopausal female--a case report. (15099979)
2004
24
Placental site trophoblastic tumor: an overview. (15457847)
2004
25
Placental site trophoblastic tumor of the uterine cervix occurring from undetermined antecedent pregnancy. (15009614)
2004
26
Ultrasound diagnosis of uterine arteriovenous fistula associated with placental site trophoblastic tumor. (12808680)
2003
27
Adrenal metastatic placental site trophoblastic tumor. Case report. (12744102)
2003
28
Placental site trophoblastic tumor. (12832940)
2003
29
Successful management of metastatic placental site trophoblastic tumor with multiple pulmonary resections. (12468357)
2002
30
Placental site trophoblastic tumor (PSTT) in mother and child: first report of PSTT in infancy. (11836719)
2002
31
Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center. (11520134)
2001
32
Spontaneous uterine perforation mimicking ectopic pregnancy as the initial presentation of placental site trophoblastic tumor. (11768287)
2001
33
Prolonged remission of recurrent, metastatic placental site trophoblastic tumor after chemotherapy. (10620452)
2000
34
Placental site trophoblastic tumor. Clinical and pathological report of two cases. (11173663)
2000
35
Failure of high-dose chemotherapy with peripheral blood stem cell support for refractory placental site trophoblastic tumor. (10087421)
1999
36
MR appearance of placental site trophoblastic tumor: a report of three cases. (9456970)
1998
37
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
38
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
39
Metastatic placental site trophoblastic tumor: long-term remission in a patient treated with EMA/CO chemotherapy. (9454662)
1998
40
Unusual endovaginal ultrasonography and magnetic resonance imaging of placental site trophoblastic tumor. (8141195)
1994
41
Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. (7691711)
1993
42
Metastasizing placental site trophoblastic tumor. An immunohistochemical and flow cytometric study of two cases. (8396853)
1993
43
Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor. (11576278)
1992
44
Erythrocytosis associated with a placental-site trophoblastic tumor. (1314361)
1992
45
Placental site trophoblastic tumor associated with immature ovarian teratoma. (1972122)
1990
46
Sonographic appearance of placental site trophoblastic tumor. (2170669)
1990
47
Clinical characteristics of placental site trophoblastic tumor (PSTT). (2842238)
1988
48
Malignant placental site trophoblastic tumor. (2991836)
1985
49
Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. (6329973)
1984
50
Placental site trophoblastic tumor of the uterus: an ultrastructural and immunohistochemical study. (6091306)
1984

Variations for Placental Site Trophoblastic Tumor

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Expression for genes affiliated with Placental Site Trophoblastic Tumor

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Expression patterns in normal tissues for genes affiliated with Placental Site Trophoblastic Tumor

Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

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Pathways related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5EGFR, ERBB2
29.5ERBB2, EGFR
39.5EGFR, ERBB2
4
Show member pathways
9.5EGFR, ERBB2
59.5ERBB2, EGFR
6
Show member pathways
9.2CGB5, CGA, CGB
7
Show member pathways
9.2ERBB2, EGFR, CGA
89.1ERBB2, GPC3, EGFR

Compounds for genes affiliated with Placental Site Trophoblastic Tumor

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Compounds related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1griseofulvin44 1110.9KRT18, CGA
211-ketotestosterone449.9CGB5, CGA
3ag 1478 hydrochloride619.8ERBB2, EGFR
4iressa619.8ERBB2, EGFR
5ag 490619.8ERBB2, EGFR
6pd158780449.8ERBB2, EGFR
7afatinib50 1110.8EGFR, ERBB2
8jnj 28871063 hydrochloride619.8ERBB2, EGFR
9pertuzumab44 50 1111.7ERBB2, EGFR
10oestriol449.6CGB5, CGB, CGA
11ctp449.6CGA, CGB5, CGB
12clomiphene citrate449.6CGB5, CGA, CGB
13anastrozole44 50 1111.6CGA, EGFR, ERBB2
14ifosfamide44 1110.6CGB, CGA, CGB5
15letrozole44 50 61 1112.5EGFR, ERBB2, CGA
16fulvestrant44 50 28 1112.5ERBB2, EGFR, KRT18
17hrgbeta1449.5EGFR, ERBB2
18quinazoline449.5EGFR, ERBB2
19bleomycin44 1110.5CGA, CGB5, CGB
20androstenedione44 2410.4CGA, CGB5, CGB
21organon449.4CGB5, CGA
22cetrorelix44 28 1111.4EGFR, CGB5, CGA
23tetracycline44 1110.3ERBB2, KRT18, EGFR
24carboplatin44 50 1111.3EGFR, ERBB2, CGA
25mifepristone44 28 61 1112.3CGB, CGB5, CGA
26pki-166449.2ERBB2, EGFR
27gnrh449.1ERBB2, CGB5, CGB, CGA
28methotrexate50 44 1111.1ERBB2, CGA, CGB5, CGB
29etoposide44 50 61 1112.1ERBB2, CGB, CGA, CGB5
30dmso449.0ALPP, KRT18, CGA, CGB5
31leucovorin44 50 1111.0CGB, CGB5, EGFR, ERBB2
32ascorbic acid44 2410.0ALPP, KRT18, CGA, CGB5
33folate448.9ERBB2, CGA, CGB5, ALPP
34cyclophosphamide44 50 1110.8ERBB2, CGA, CGB5, CGB, KRT18
35alanine448.8CGA, ERBB2, ALPP, KRT18, CGB
36creatinine448.7CGB, ALPP, KRT18, CGB5, CGA
37doxorubicin44 50 1110.6EGFR, CGB5, CGA, KRT18, ERBB2
38genistein44 28 61 2 24 1113.6ALPP, ERBB2, EGFR, CGB5
39pge2448.5EGFR, CGA, CGB5, ALPP
40progestin448.5ALPP, CGB5, CGA, EGFR, ERBB2
41tamoxifen44 50 28 1111.4CGB5, ERBB2, ALPP, EGFR, CGA
42cycloheximide448.4CGA, CGB5, ERBB2, EGFR, ALPP
43lactate448.3KRT18, CGB5, CGA, CGB, ALPP, ERBB2
44progesterone44 28 61 24 1112.3CGB5, CGB, EGFR, ERBB2, KRT18, CGA
45cisplatin44 50 61 1111.1CGB, CGA, CGB5, ALPP, ERBB2, EGFR
46paraffin448.1ALPP, KRT18, EGFR, CGA, CGB5, ERBB2
47serine448.0EGFR, CGA, CGB5, KRT18, ALPP, ERBB2
48testosterone44 61 24 1110.8ALPP, ERBB2, KRT18, EGFR, CGB, CGA
49vegf447.8CGB5, CGA, CGB, EGFR, KRT18, ERBB2
50estrogen447.8EGFR, ALPP, CGB, CGA, CGB5, ERBB2

GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

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Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.8CGA, CGB
2positive regulation of epithelial cell proliferationGO:0506799.5EGFR, ERBB2
3positive regulation of MAP kinase activityGO:0434069.2EGFR, ERBB2
4anatomical structure morphogenesisGO:0096538.9KRT18, MCAM, GPC3
5signal transductionGO:0071658.7ERBB2, EGFR, CGB, CGA

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.5EGFR, ERBB2
2protein phosphatase bindingGO:0199039.5EGFR, ERBB2
3receptor signaling protein tyrosine kinase activityGO:0047169.4EGFR, ERBB2
4transmembrane receptor protein tyrosine kinase activityGO:0047149.2EGFR, ERBB2

Products for genes affiliated with Placental Site Trophoblastic Tumor

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Sources for Placental Site Trophoblastic Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet