PSST
MCID: PLC003
MIFTS: 58

Placental Site Trophoblastic Tumor (PSST) malady

Rare diseases, Cancer diseases, Reproductive diseases categories

Summaries for Placental Site Trophoblastic Tumor

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66Wikipedia, 34MalaCards
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Wikipedia:66 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards: Placental Site Trophoblastic Tumor, also known as trophoblastic tumor placental site, is related to epithelioid trophoblastic tumor and choriocarcinoma, and has symptoms including spontaneous abortions, neoplasms/tumors and central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer. An important gene associated with Placental Site Trophoblastic Tumor is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Alzheimers Disease Pathway and Agrin Interactions at Neuromuscular Junction. The compounds griseofulvin and 11-ketotestosterone have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and lung, and related mouse phenotypes are reproductive system and embryogenesis.

Aliases & Classifications for Placental Site Trophoblastic Tumor

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

50
placental site trophoblastic tumor:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


Aliases & Descriptions:

placental site trophoblastic tumor 9 11 50
trophoblastic tumor placental site 44 46
placental-site gestational trophoblastic neoplasm 9
trophoblastic tumor, placental site 63
neoplasm of placenta 63
placenta neoplasm 44
psst 50


External Ids:

Disease Ontology9 DOID:3596
NCIt41 C3757
MeSH36 D018245
MESH via Orphanet37 D018245
SNOMED-CT59 75320001, 237252008
ICD10 via Orphanet27 D39.2
SNOMED-CT via Orphanet60 237252008, 75320001
UMLS via Orphanet64 C0206666
ICD1026 C58

Related Diseases for Placental Site Trophoblastic Tumor

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18GeneCards, 19GeneDecks
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Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid trophoblastic tumor30.9MCAM
2choriocarcinoma30.8KRT18, CGB, CGB5, ALPP, GPC3, CGA
3ectopic pregnancy30.8CGB, CGA, CGB5
4trophoblastic neoplasm30.8CGA, CGB5
5gestational trophoblastic neoplasm30.7ALPP, CGB, CGA, CGB5
6teratoma30.6CGA, CGB5, CGB, ALPP, GPC3
7precocious puberty30.6CGA, CGB5
8cervicitis10.5
9leiomyoma10.5
10germ cell tumors10.5
11arteriovenous fistula10.3
12placental abruption10.3
13infertility10.3
14placenta accreta10.3
15alopecia10.3
16alopecia areata10.3
17pneumothorax10.3
18proteinuria10.3
19vaginitis10.3
20nonseminomatous germ cell tumor10.3
21erythrocytosis10.3
22testicular germ cell tumor10.3
23invasive mole10.3
24extragonadal germ cell tumor10.1CGB5
25superior vena cava syndrome10.1CGB
26anencephaly10.1CGA
27cryptococcosis10.1CGB, CGB5
28ovarian cyst10.1CGB5, CGA
29ovarian hyperstimulation syndrome10.1CGA, CGB5
30gynecomastia10.1CGB5, CGA
31oligospermia10.1CGA, CGB5
32germ cell cancer10.1ALPP, CGA
33kallmann syndrome10.1CGA, CGB5
34turner syndrome10.1CGA, CGB
35polycystic ovary syndrome10.1CGA, CGB5
36leydig cell tumor10.1CGB5, CGA
37thymus cancer10.1ALPP, KRT18
38klinefelter's syndrome10.1CGA, CGB
39hyperandrogenism10.0CGA, CGB5
40endodermal sinus tumor10.0CGB5, CGB, ALPP
41gestational trophoblastic tumor10.0CGA, CGB, CGB5
42hyperprolactinemia10.0CGB5, CGA, CGB
43pregnancy loss10.0CGB5, CGA, CGB
44neural tube defects10.0CGB, CGA, CGB5
45deficiency anemia10.0ALPP, CGB, CGB5
46down syndrome10.0CGB5, CGB, CGA
47dysgerminoma10.0ALPP, CGA, CGB5
48cryptorchidism10.0CGB5, ALPP, CGA
49prolactinoma10.0CGA, CGB
50brain cancer10.0EGFR, CGB, CGB5

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Symptoms for Placental Site Trophoblastic Tumor

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Sources:
50Orphanet
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Symptoms:

50 (show all 9)
  • spontaneous abortions
  • neoplasms/tumors
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • antenatal period/pregnancy anomalies
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Placental Site Trophoblastic Tumor

Drug clinical trials:

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Search NIH Clinical Center for Placental Site Trophoblastic Tumor

Search CenterWatch for Placental Site Trophoblastic Tumor

Genetic Tests for Placental Site Trophoblastic Tumor

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Anatomical Context for Placental Site Trophoblastic Tumor

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34MalaCards
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MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

34
Placenta, Uterus, Lung, Cervix, Liver, Ovary, Testis, Brain, Adrenal gland, Kidney, Testes, Lymph node

Animal Models for Placental Site Trophoblastic Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2CGA, EGFR, ERBB2, ALPP, GPC3
2MP:00053808.1EGFR, KRT18, ERBB2, ALPP, GPC3
3MP:00053787.5GPC3, ALPP, ERBB2, KRT18, EGFR, CGA

Publications for Placental Site Trophoblastic Tumor

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53PubMed
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Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 143)
idTitleAuthorsYear
1
Unsuccessful planned conservative resection of placental site trophoblastic tumor. (23344410)
2013
2
Placental site trophoblastic tumor, report of a case with unusual presentation. (23478075)
2013
3
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. (23040933)
2012
4
Clinical features of 17 cases of placental site trophoblastic tumor. (21862010)
2011
5
Kidney involvement in a patient affected by placental site trophoblastic tumor. (21257242)
2011
6
Two cases of placental site trophoblastic tumor. (22030056)
2011
7
Placental site trophoblastic tumor--a challenging, rare entity. (21199764)
2010
8
Placental site trophoblastic tumor presenting as a friable cervical mass. (21061804)
2010
9
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. (20381116)
2010
10
Placental site trophoblastic tumor: lymphatic spread and possible target markers. (19910023)
2010
11
Placental site trophoblastic tumor. (19935163)
2009
12
Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. (19366068)
2009
13
Survival of placental-site trophoblastic tumor patients strongly linked with time since related pregnancy. (19670504)
2009
14
Placental-site trophoblastic tumors: a case of resistant pulmonary metastasis. (18227827)
2008
15
Absence of Y chromosome in human placental site trophoblastic tumor. (17643092)
2007
16
Fertility sparing therapy in a patient with placental site trophoblastic tumor: a case report. (17007914)
2006
17
Exclusion of lung metastases in placental site trophoblastic tumor using [18F]fluorodeoxyglucose positron emission tomography: a case report. (16051337)
2005
18
Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature. (15958158)
2005
19
Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor. (16127165)
2005
20
p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. (15316317)
2004
21
Placental site trophoblastic tumor in a postmenopausal female--a case report. (15099979)
2004
22
Placental site trophoblastic tumor: an overview. (15457847)
2004
23
Placental site trophoblastic tumor of the uterine cervix occurring from undetermined antecedent pregnancy. (15009614)
2004
24
Ultrasound diagnosis of uterine arteriovenous fistula associated with placental site trophoblastic tumor. (12808680)
2003
25
Adrenal metastatic placental site trophoblastic tumor. Case report. (12744102)
2003
26
Placental site trophoblastic tumor. (12832940)
2003
27
Successful management of metastatic placental site trophoblastic tumor with multiple pulmonary resections. (12468357)
2002
28
Placental site trophoblastic tumor (PSTT) in mother and child: first report of PSTT in infancy. (11836719)
2002
29
Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center. (11520134)
2001
30
Spontaneous uterine perforation mimicking ectopic pregnancy as the initial presentation of placental site trophoblastic tumor. (11768287)
2001
31
Prolonged remission of recurrent, metastatic placental site trophoblastic tumor after chemotherapy. (10620452)
2000
32
Placental site trophoblastic tumor. Clinical and pathological report of two cases. (11173663)
2000
33
Pathogenesis of placental site trophoblastic tumor may require the presence of a paternally derived X chromosome. (10879746)
2000
34
Failure of high-dose chemotherapy with peripheral blood stem cell support for refractory placental site trophoblastic tumor. (10087421)
1999
35
MR appearance of placental site trophoblastic tumor: a report of three cases. (9456970)
1998
36
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
37
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
38
Metastatic placental site trophoblastic tumor: long-term remission in a patient treated with EMA/CO chemotherapy. (9454662)
1998
39
Unusual endovaginal ultrasonography and magnetic resonance imaging of placental site trophoblastic tumor. (8141195)
1994
40
Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. (7691711)
1993
41
Metastasizing placental site trophoblastic tumor. An immunohistochemical and flow cytometric study of two cases. (8396853)
1993
42
Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor. (11576278)
1992
43
Erythrocytosis associated with a placental-site trophoblastic tumor. (1314361)
1992
44
Placental site trophoblastic tumor associated with immature ovarian teratoma. (1972122)
1990
45
Sonographic appearance of placental site trophoblastic tumor. (2170669)
1990
46
Clinical characteristics of placental site trophoblastic tumor (PSTT). (2842238)
1988
47
Malignant placental site trophoblastic tumor. (2991836)
1985
48
&quot;Fibrinothrombotic glomerulopathy&quot; in patients with placental site trophoblastic tumor and nephrotic proteinuria. (2997021)
1985
49
Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. (6329973)
1984
50
Placental site trophoblastic tumor of the uterus: an ultrastructural and immunohistochemical study. (6091306)
1984

Variations for Placental Site Trophoblastic Tumor

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Expression for genes affiliated with Placental Site Trophoblastic Tumor

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Placental Site Trophoblastic Tumor

Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

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Sources:
51PathCards, 54QIAGEN, 58SinoBiological, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG
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Pathways related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5EGFR, ERBB2
29.5EGFR, ERBB2
39.5EGFR, ERBB2
4
Show member pathways
9.5EGFR, ERBB2
59.5ERBB2, EGFR
6
Show member pathways
9.2CGB5, CGA, CGB
7
Show member pathways
9.2CGA, EGFR, ERBB2
89.1GPC3, ERBB2, EGFR

Compounds for genes affiliated with Placental Site Trophoblastic Tumor

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1griseofulvin46 1210.9KRT18, CGA
211-ketotestosterone469.9CGB5, CGA
3ag 1478 hydrochloride629.8ERBB2, EGFR
4iressa629.8ERBB2, EGFR
5ag 490629.8ERBB2, EGFR
6pd158780469.8ERBB2, EGFR
7afatinib52 1210.8EGFR, ERBB2
8jnj 28871063 hydrochloride629.8ERBB2, EGFR
9pertuzumab46 52 1211.7ERBB2, EGFR
10oestriol469.6CGB5, CGB, CGA
11ctp469.6CGA, CGB5, CGB
12clomiphene citrate469.6CGB5, CGA, CGB
13anastrozole46 52 1211.6CGA, EGFR, ERBB2
14ifosfamide46 1210.6CGB, CGA, CGB5
15letrozole46 52 62 1212.5EGFR, ERBB2, CGA
16fulvestrant46 52 30 1212.5ERBB2, EGFR, KRT18
17hrgbeta1469.5EGFR, ERBB2
18quinazoline469.5EGFR, ERBB2
19bleomycin46 1210.5CGA, CGB5, CGB
20androstenedione46 2510.4CGA, CGB5, CGB
21organon469.4CGB5, CGA
22cetrorelix46 30 1211.4EGFR, CGB5, CGA
23tetracycline46 1210.3ERBB2, KRT18, EGFR
24carboplatin46 52 1211.3EGFR, ERBB2, CGA
25mifepristone46 30 62 1212.3CGB, CGB5, CGA
26pki-166469.2ERBB2, EGFR
27gnrh469.1ERBB2, CGB5, CGB, CGA
28methotrexate52 46 1211.1ERBB2, CGA, CGB5, CGB
29etoposide46 52 62 1212.1ERBB2, CGB, CGA, CGB5
30dmso469.0ALPP, KRT18, CGA, CGB5
31leucovorin46 52 1211.0CGB, CGB5, EGFR, ERBB2
32ascorbic acid46 2510.0ALPP, KRT18, CGA, CGB5
33folate468.9ERBB2, CGA, CGB5, ALPP
34cyclophosphamide46 52 1210.8ERBB2, CGA, CGB5, CGB, KRT18
35alanine468.8CGA, ERBB2, ALPP, KRT18, CGB
36creatinine468.7CGB, ALPP, KRT18, CGB5, CGA
37doxorubicin46 52 1210.6EGFR, CGB5, CGA, KRT18, ERBB2
38genistein46 30 62 3 25 1213.6ALPP, ERBB2, EGFR, CGB5
39pge2468.5EGFR, CGA, CGB5, ALPP
40progestin468.5ALPP, CGB5, CGA, EGFR, ERBB2
41tamoxifen46 52 30 1211.4CGB5, ERBB2, ALPP, EGFR, CGA
42cycloheximide468.4CGA, CGB5, ERBB2, EGFR, ALPP
43lactate468.3KRT18, CGB5, CGA, CGB, ALPP, ERBB2
44progesterone46 30 62 25 1212.3CGB5, CGB, EGFR, ERBB2, KRT18, CGA
45cisplatin46 52 62 1211.1CGB, CGA, CGB5, ALPP, ERBB2, EGFR
46paraffin468.1ALPP, KRT18, EGFR, CGA, CGB5, ERBB2
47serine468.0EGFR, CGA, CGB5, KRT18, ALPP, ERBB2
48testosterone46 62 25 1210.8ALPP, ERBB2, KRT18, EGFR, CGB, CGA
49vegf467.8CGB5, CGA, CGB, EGFR, KRT18, ERBB2
50estrogen467.8EGFR, ALPP, CGB, CGA, CGB5, ERBB2

GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

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17Gene Ontology
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Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.8CGA, CGB
2positive regulation of epithelial cell proliferationGO:0506799.5EGFR, ERBB2
3positive regulation of MAP kinase activityGO:0434069.2EGFR, ERBB2
4anatomical structure morphogenesisGO:0096538.9KRT18, MCAM, GPC3
5signal transductionGO:0071658.7ERBB2, EGFR, CGB, CGA

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.5EGFR, ERBB2
2protein phosphatase bindingGO:0199039.5EGFR, ERBB2
3receptor signaling protein tyrosine kinase activityGO:0047169.4EGFR, ERBB2
4transmembrane receptor protein tyrosine kinase activityGO:0047149.2EGFR, ERBB2

Products for genes affiliated with Placental Site Trophoblastic Tumor

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  • Antibodies
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Sources for Placental Site Trophoblastic Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet