PSST
MCID: PLC003
MIFTS: 58

Placental Site Trophoblastic Tumor (PSST) malady

Rare diseases, Cancer diseases, Reproductive diseases categories
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Summaries for Placental Site Trophoblastic Tumor

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65Wikipedia, 33MalaCards
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Wikipedia:65 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards: Placental Site Trophoblastic Tumor, also known as trophoblastic tumor placental site, is related to epithelioid trophoblastic tumor and choriocarcinoma, and has symptoms including spontaneous abortions, neoplasms/tumors and central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer. An important gene associated with Placental Site Trophoblastic Tumor is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Alzheimers Disease Pathway and Agrin Interactions at Neuromuscular Junction. The compounds griseofulvin and 11-ketotestosterone have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and lung, and related mouse phenotypes are reproductive system and embryogenesis.

Aliases & Classifications for Placental Site Trophoblastic Tumor

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

49
placental site trophoblastic tumor:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


Aliases & Descriptions:

placental site trophoblastic tumor 8 10 49
trophoblastic tumor placental site 43 45
placental-site gestational trophoblastic neoplasm 8
trophoblastic tumor, placental site 62
neoplasm of placenta 62
placenta neoplasm 43
psst 49


External Ids:

Disease Ontology8 DOID:3596
NCIt40 C3757
MeSH35 D018245
MESH via Orphanet36 D018245
SNOMED-CT58 75320001, 237252008
ICD10 via Orphanet26 D39.2
SNOMED-CT via Orphanet59 237252008, 75320001
UMLS via Orphanet63 C0206666
ICD1025 C58

Related Diseases for Placental Site Trophoblastic Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid trophoblastic tumor30.9MCAM
2choriocarcinoma30.8KRT18, CGB, CGB5, ALPP, GPC3, CGA
3ectopic pregnancy30.8CGB, CGA, CGB5
4trophoblastic neoplasm30.8CGA, CGB5
5gestational trophoblastic neoplasm30.7ALPP, CGB, CGA, CGB5
6teratoma30.6CGA, CGB5, CGB, ALPP, GPC3
7precocious puberty30.6CGA, CGB5
8cervicitis10.5
9leiomyoma10.5
10germ cell tumors10.5
11arteriovenous fistula10.3
12placental abruption10.3
13infertility10.3
14placenta accreta10.3
15alopecia10.3
16alopecia areata10.3
17pneumothorax10.3
18proteinuria10.3
19vaginitis10.3
20nonseminomatous germ cell tumor10.3
21erythrocytosis10.3
22testicular germ cell tumor10.3
23invasive mole10.3
24extragonadal germ cell tumor10.1CGB5
25superior vena cava syndrome10.1CGB
26anencephaly10.1CGA
27cryptococcosis10.1CGB, CGB5
28ovarian cyst10.1CGB5, CGA
29ovarian hyperstimulation syndrome10.1CGA, CGB5
30gynecomastia10.1CGB5, CGA
31oligospermia10.1CGA, CGB5
32germ cell cancer10.1ALPP, CGA
33kallmann syndrome10.1CGA, CGB5
34turner syndrome10.1CGA, CGB
35polycystic ovary syndrome10.1CGA, CGB5
36leydig cell tumor10.1CGB5, CGA
37thymus cancer10.1ALPP, KRT18
38klinefelter's syndrome10.1CGA, CGB
39hyperandrogenism10.0CGA, CGB5
40endodermal sinus tumor10.0CGB5, CGB, ALPP
41gestational trophoblastic tumor10.0CGA, CGB, CGB5
42hyperprolactinemia10.0CGB5, CGA, CGB
43pregnancy loss10.0CGB5, CGA, CGB
44neural tube defects10.0CGB, CGA, CGB5
45deficiency anemia10.0ALPP, CGB, CGB5
46down syndrome10.0CGB5, CGB, CGA
47dysgerminoma10.0ALPP, CGA, CGB5
48cryptorchidism10.0CGB5, ALPP, CGA
49prolactinoma10.0CGA, CGB
50brain cancer10.0EGFR, CGB, CGB5

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Symptoms for Placental Site Trophoblastic Tumor

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Sources:
49Orphanet
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Symptoms:

49 (show all 9)
  • spontaneous abortions
  • neoplasms/tumors
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • antenatal period/pregnancy anomalies
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Placental Site Trophoblastic Tumor

Search NIH Clinical Center for Placental Site Trophoblastic Tumor

Genetic Tests for Placental Site Trophoblastic Tumor

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Anatomical Context for Placental Site Trophoblastic Tumor

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33MalaCards
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MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

33
Placenta, Uterus, Lung, Cervix, Liver, Ovary, Testis, Brain, Adrenal gland, Kidney, Testes, Lymph node

Animal Models for Placental Site Trophoblastic Tumor or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2CGA, EGFR, ERBB2, ALPP, GPC3
2MP:00053808.1EGFR, KRT18, ERBB2, ALPP, GPC3
3MP:00053787.5GPC3, ALPP, ERBB2, KRT18, EGFR, CGA

Publications for Placental Site Trophoblastic Tumor

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52PubMed
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Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 143)
idTitleAuthorsYear
1
Unsuccessful planned conservative resection of placental site trophoblastic tumor. (23344410)
2013
2
Placental site trophoblastic tumor, report of a case with unusual presentation. (23478075)
2013
3
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. (23040933)
2012
4
Clinical features of 17 cases of placental site trophoblastic tumor. (21862010)
2011
5
Kidney involvement in a patient affected by placental site trophoblastic tumor. (21257242)
2011
6
Two cases of placental site trophoblastic tumor. (22030056)
2011
7
Placental site trophoblastic tumor--a challenging, rare entity. (21199764)
2010
8
Placental site trophoblastic tumor presenting as a friable cervical mass. (21061804)
2010
9
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. (20381116)
2010
10
Placental site trophoblastic tumor: lymphatic spread and possible target markers. (19910023)
2010
11
Placental site trophoblastic tumor. (19935163)
2009
12
Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. (19366068)
2009
13
Survival of placental-site trophoblastic tumor patients strongly linked with time since related pregnancy. (19670504)
2009
14
Placental-site trophoblastic tumors: a case of resistant pulmonary metastasis. (18227827)
2008
15
Absence of Y chromosome in human placental site trophoblastic tumor. (17643092)
2007
16
Fertility sparing therapy in a patient with placental site trophoblastic tumor: a case report. (17007914)
2006
17
Exclusion of lung metastases in placental site trophoblastic tumor using [18F]fluorodeoxyglucose positron emission tomography: a case report. (16051337)
2005
18
Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature. (15958158)
2005
19
Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor. (16127165)
2005
20
p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. (15316317)
2004
21
Placental site trophoblastic tumor in a postmenopausal female--a case report. (15099979)
2004
22
Placental site trophoblastic tumor: an overview. (15457847)
2004
23
Placental site trophoblastic tumor of the uterine cervix occurring from undetermined antecedent pregnancy. (15009614)
2004
24
Ultrasound diagnosis of uterine arteriovenous fistula associated with placental site trophoblastic tumor. (12808680)
2003
25
Adrenal metastatic placental site trophoblastic tumor. Case report. (12744102)
2003
26
Placental site trophoblastic tumor. (12832940)
2003
27
Successful management of metastatic placental site trophoblastic tumor with multiple pulmonary resections. (12468357)
2002
28
Placental site trophoblastic tumor (PSTT) in mother and child: first report of PSTT in infancy. (11836719)
2002
29
Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center. (11520134)
2001
30
Spontaneous uterine perforation mimicking ectopic pregnancy as the initial presentation of placental site trophoblastic tumor. (11768287)
2001
31
Prolonged remission of recurrent, metastatic placental site trophoblastic tumor after chemotherapy. (10620452)
2000
32
Placental site trophoblastic tumor. Clinical and pathological report of two cases. (11173663)
2000
33
Pathogenesis of placental site trophoblastic tumor may require the presence of a paternally derived X chromosome. (10879746)
2000
34
Failure of high-dose chemotherapy with peripheral blood stem cell support for refractory placental site trophoblastic tumor. (10087421)
1999
35
MR appearance of placental site trophoblastic tumor: a report of three cases. (9456970)
1998
36
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
37
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
38
Metastatic placental site trophoblastic tumor: long-term remission in a patient treated with EMA/CO chemotherapy. (9454662)
1998
39
Unusual endovaginal ultrasonography and magnetic resonance imaging of placental site trophoblastic tumor. (8141195)
1994
40
Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. (7691711)
1993
41
Metastasizing placental site trophoblastic tumor. An immunohistochemical and flow cytometric study of two cases. (8396853)
1993
42
Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor. (11576278)
1992
43
Erythrocytosis associated with a placental-site trophoblastic tumor. (1314361)
1992
44
Placental site trophoblastic tumor associated with immature ovarian teratoma. (1972122)
1990
45
Sonographic appearance of placental site trophoblastic tumor. (2170669)
1990
46
Clinical characteristics of placental site trophoblastic tumor (PSTT). (2842238)
1988
47
Malignant placental site trophoblastic tumor. (2991836)
1985
48
&quot;Fibrinothrombotic glomerulopathy&quot; in patients with placental site trophoblastic tumor and nephrotic proteinuria. (2997021)
1985
49
Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. (6329973)
1984
50
Placental site trophoblastic tumor of the uterus: an ultrastructural and immunohistochemical study. (6091306)
1984

Variations for Placental Site Trophoblastic Tumor

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Expression for genes affiliated with Placental Site Trophoblastic Tumor

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Placental Site Trophoblastic Tumor

Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

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50PathCards, 53QIAGEN, 57SinoBiological, 55Reactome, 38NCBI BioSystems Database, 60Thomson Reuters, 30KEGG
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Pathways related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5EGFR, ERBB2
29.5EGFR, ERBB2
39.5EGFR, ERBB2
4
Show member pathways
9.5EGFR, ERBB2
59.5ERBB2, EGFR
6
Show member pathways
9.2CGB5, CGA, CGB
7
Show member pathways
9.2CGA, EGFR, ERBB2
89.1GPC3, ERBB2, EGFR

Compounds for genes affiliated with Placental Site Trophoblastic Tumor

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Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1griseofulvin45 1110.9KRT18, CGA
211-ketotestosterone459.9CGB5, CGA
3ag 1478 hydrochloride619.8ERBB2, EGFR
4iressa619.8ERBB2, EGFR
5ag 490619.8ERBB2, EGFR
6pd158780459.8ERBB2, EGFR
7afatinib51 1110.8EGFR, ERBB2
8jnj 28871063 hydrochloride619.8ERBB2, EGFR
9pertuzumab45 51 1111.7ERBB2, EGFR
10oestriol459.6CGB5, CGB, CGA
11ctp459.6CGA, CGB5, CGB
12clomiphene citrate459.6CGB5, CGA, CGB
13anastrozole45 51 1111.6CGA, EGFR, ERBB2
14ifosfamide45 1110.6CGB, CGA, CGB5
15letrozole45 51 61 1112.5EGFR, ERBB2, CGA
16fulvestrant45 51 29 1112.5ERBB2, EGFR, KRT18
17hrgbeta1459.5EGFR, ERBB2
18quinazoline459.5EGFR, ERBB2
19bleomycin45 1110.5CGA, CGB5, CGB
20androstenedione45 2410.4CGA, CGB5, CGB
21organon459.4CGB5, CGA
22cetrorelix45 29 1111.4EGFR, CGB5, CGA
23tetracycline45 1110.3ERBB2, KRT18, EGFR
24carboplatin45 51 1111.3EGFR, ERBB2, CGA
25mifepristone45 29 61 1112.3CGB, CGB5, CGA
26pki-166459.2ERBB2, EGFR
27gnrh459.1ERBB2, CGB5, CGB, CGA
28methotrexate51 45 1111.1ERBB2, CGA, CGB5, CGB
29etoposide45 51 61 1112.1ERBB2, CGB, CGA, CGB5
30dmso459.0ALPP, KRT18, CGA, CGB5
31leucovorin45 51 1111.0CGB, CGB5, EGFR, ERBB2
32ascorbic acid45 2410.0ALPP, KRT18, CGA, CGB5
33folate458.9ERBB2, CGA, CGB5, ALPP
34cyclophosphamide45 51 1110.8ERBB2, CGA, CGB5, CGB, KRT18
35alanine458.8CGA, ERBB2, ALPP, KRT18, CGB
36creatinine458.7CGB, ALPP, KRT18, CGB5, CGA
37doxorubicin45 51 1110.6EGFR, CGB5, CGA, KRT18, ERBB2
38genistein45 29 61 3 24 1113.6ALPP, ERBB2, EGFR, CGB5
39pge2458.5EGFR, CGA, CGB5, ALPP
40progestin458.5ALPP, CGB5, CGA, EGFR, ERBB2
41tamoxifen45 51 29 1111.4CGB5, ERBB2, ALPP, EGFR, CGA
42cycloheximide458.4CGA, CGB5, ERBB2, EGFR, ALPP
43lactate458.3KRT18, CGB5, CGA, CGB, ALPP, ERBB2
44progesterone45 29 61 24 1112.3CGB5, CGB, EGFR, ERBB2, KRT18, CGA
45cisplatin45 51 61 1111.1CGB, CGA, CGB5, ALPP, ERBB2, EGFR
46paraffin458.1ALPP, KRT18, EGFR, CGA, CGB5, ERBB2
47serine458.0EGFR, CGA, CGB5, KRT18, ALPP, ERBB2
48testosterone45 61 24 1110.8ALPP, ERBB2, KRT18, EGFR, CGB, CGA
49vegf457.8CGB5, CGA, CGB, EGFR, KRT18, ERBB2
50estrogen457.8EGFR, ALPP, CGB, CGA, CGB5, ERBB2

GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

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16Gene Ontology
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Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.8CGA, CGB
2positive regulation of epithelial cell proliferationGO:0506799.5EGFR, ERBB2
3positive regulation of MAP kinase activityGO:0434069.2EGFR, ERBB2
4anatomical structure morphogenesisGO:0096538.9KRT18, MCAM, GPC3
5signal transductionGO:0071658.7ERBB2, EGFR, CGB, CGA

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.5EGFR, ERBB2
2protein phosphatase bindingGO:0199039.5EGFR, ERBB2
3receptor signaling protein tyrosine kinase activityGO:0047169.4EGFR, ERBB2
4transmembrane receptor protein tyrosine kinase activityGO:0047149.2EGFR, ERBB2

Products for genes affiliated with Placental Site Trophoblastic Tumor

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  • Antibodies
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Sources for Placental Site Trophoblastic Tumor

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet