MCID: PLC003
MIFTS: 47

Placental Site Trophoblastic Tumor malady

Categories: Rare diseases, Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Placental Site Trophoblastic Tumor

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Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Placental Site Trophoblastic Tumor:

Name: Placental Site Trophoblastic Tumor 11 54 13
Trophoblastic Tumor, Placental Site 39 68
Trophoblastic Tumor Placental Site 48 50
Placental-Site Gestational Trophoblastic Neoplasm 11
 
Placenta Neoplasm 48
Deciduoma 68
Psst 54

Characteristics:

Orphanet epidemiological data:

54
placental site trophoblastic tumor:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Disease Ontology11 DOID:3596
MeSH39 D018245
NCIt45 C3757
Orphanet54 ORPHA99928
SNOMED-CT62 237252008, 75320001
MESH via Orphanet40 D018245
ICD10 via Orphanet31 D39.2
UMLS via Orphanet69 C0206666
ICD1030 C58

Summaries for Placental Site Trophoblastic Tumor

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Wikipedia:71 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards based summary: Placental Site Trophoblastic Tumor, also known as trophoblastic tumor, placental site, is related to lethal restrictive dermopathy, lmna-related and calcaneonavicular coalition, and has symptoms including abnormality of the menstrual cycle, spontaneous abortion and uterine neoplasm. An important gene associated with Placental Site Trophoblastic Tumor is INHA (Inhibin Alpha Subunit), and among its related pathways are Agrin Interactions at Neuromuscular Junction and Alzheimers Disease Pathway. Affiliated tissues include placenta, lung and uterus, and related mouse phenotypes are Decreased viability with paclitaxel and limbs/digits/tail.

Related Diseases for Placental Site Trophoblastic Tumor

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Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1lethal restrictive dermopathy, lmna-related10.3EGFR, VEGFA
2calcaneonavicular coalition10.3EGFR, VEGFA
3stampe sorensen syndrome10.3EGFR, VEGFA
4nonsyndromic hereditary sensorineural hearing loss10.3CGB5, ERBB2
5kidney pelvis sarcomatoid transitional cell carcinoma10.3EGFR, ERBB2
6prostate adenoid cystic carcinoma10.3EGFR, VEGFA
7choriocarcinoma10.3
8mantle cell lymphoma10.2EGFR, VEGFA
9ossifying fibromyxoid tumor10.2EGFR, ERBB2
10her2-receptor negative breast cancer10.2EGFR, ERBB2
11glottis verrucous carcinoma10.2EGFR, ERBB2
12integumentary system cancer10.2EGFR, VEGFA
13bladder colonic type adenocarcinoma10.2EGFR, ERBB2
14animal phobia10.2EGFR, ERBB2
15gastric squamous cell carcinoma10.2EGFR, ERBB2
16breast papillary carcinoma10.2EGFR, ERBB2
17anomalous left coronary artery from the pulmonary artery10.2EGFR, ERBB2
18apocrine adenocarcinoma10.2EGFR, ERBB2
19ovarian small cell carcinoma10.2EGFR, ERBB2
20oral lichen planus10.2EGFR, VEGFA
21central centrifugal cicatricial alopecia10.2EGFR, ERBB2
22adenosquamous carcinoma10.2EGFR, ERBB2
23pleomorphic carcinoma10.2EGFR, ERBB2
24adenomyosis10.2EGFR, ERBB2
25scrotal carcinoma10.2EGFR, ERBB2
26novak syndrome10.2EGFR, ERBB2
27paranasal sinus cancer, adult10.2ERBB2, INHA
28ampulla of vater adenocarcinoma10.2EGFR, ERBB2
29verloove vanhorick brubakk syndrome10.2EGFR, VEGFA
30ductal carcinoma in situ10.2EGFR, ERBB2
31early congenital syphilis10.2EGFR, ERBB2
32postpoliomyelitis syndrome10.1EGFR, ERBB2
33fallopian tube mucinous adenocarcinoma10.1EGFR, ERBB2
34epithelioid trophoblastic tumor10.1
35milker's nodule10.1EGFR, ERBB2
36tonsil cancer10.1EGFR, ERBB2
37weaver johnson syndrome10.1ERBB2, VEGFA
38richter's syndrome10.1EGFR, VEGFA
39teratoma10.1
40leiomyosarcoma10.1ERBB2, VEGFA
41progesterone-receptor positive breast cancer10.1EGFR, ERBB2
42cerebellar vermis medulloblastoma10.0EGFR, VEGFA
43lateral sclerosis10.0CSH1, VEGFA
44dysgraphia10.0EGFR, ERBB2
45trophoblastic neoplasm10.0
46leigh syndrome10.0
47duodenal somatostatinoma10.0EGFR, VEGFA
48lung carcinoma in situ10.0ERBB2, VEGFA
49ectopic pregnancy10.0
50leiomyoma10.0

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Symptoms & Phenotypes for Placental Site Trophoblastic Tumor

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Human phenotypes related to Placental Site Trophoblastic Tumor:

 64 54 (show all 10)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the menstrual cycle64 hallmark (90%) HP:0000140
2 spontaneous abortion64 54 hallmark (90%) Very frequent (99-80%) HP:0005268
3 uterine neoplasm64 hallmark (90%) HP:0010784
4 neoplasm of the liver64 occasional (7.5%) HP:0002896
5 neoplasm of the nervous system64 occasional (7.5%) HP:0004375
6 neoplasm of the lung64 occasional (7.5%) HP:0100526
7 vaginal neoplasm64 occasional (7.5%) HP:0100650
8 amenorrhea54 Very frequent (99-80%)
9 low maternal serum chorionic gonadotropin54 Very frequent (99-80%)
10 metrorrhagia54 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00293-A10.1EGFR, ERBB2

MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8EGFR, ERBB2, GPC3, VEGFA
2MP:00053818.5EGFR, ERBB2, GPC3, INHA, VEGFA
3MP:00020068.2EGFR, ERBB2, INHA, VEGFA
4MP:00053858.2EGFR, ERBB2, GPC3, INHA, LNPEP, VEGFA

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

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Drugs for Placental Site Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Chorionic GonadotropinPhase 4188
2
Bevacizumabapproved, investigationalPhase 21968216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
3
Nitroglycerinapproved, investigationalPhase 215055-63-04510
Synonyms:
1,2,3-Propanetrioltrinitrate
1,2,3-Propanetriyl nitrate
100292-13-5
105469-31-6
55-63-0
80066-48-4
8013-23-8
9010-02-0
AC1L1IBV
Adesitrin
Aldonitrin
Angibid
Angiolingual
Angiplex
Anglix
Angonist
Angorin
Anogesic
Aquo-Trimitrosan
BIDD:GT0142
BRN 1802063
Blasting gelatin
Blasting oil
Buccal
Buccard
C07455
C3H5N3O9
CCRIS 4089
CHEBI:28787
CHEMBL730
CID4510
CPD-143
Cardabid
Cardamist
Cardinit
Cardiodisco
Cellegesic
Chitamite
Colenitral
Cordipatch
Corditrine
Coro-Nitro
D00515
D005996
DB00727
Dauxona
Deponit
Deponit 5
Deponit TTS 10
Deponit TTS 5
Deponit-5
Diafusor
Discotrine
Dynamite
EINECS 200-240-8
Epinitril
GTN
GTN-Pohl
Gepan Nitroglicerin
Gilucor nitro
Gilustenon
Glonoin
Glycerin trinitrate
Glycerine trinitrate
Glycerintrinitrate
Glycerol trinitrate
Glycerol, nitric acid triester
Glyceroli trinitratis
Glyceroltrinitraat
Glyceroltrinitrat
Glyceryl
Glyceryl nitrate
Glyceryl trinitrate
Glycerylnitrat
Glytrin
HMS2094M15
HSDB 30
Herwicard
Herzer
IMX-150
Klavikordal
LS-7741
Lenitral
Lentonitrina
MED-2002
MQX-503
Mi-Trates
Millisrol
Minitram
Minitran
Minitran (TN)
Minitro
Mionitrat
Myocon
Myoglycerin
Myovin
NG
NITRO IV
NK-843
NTG
Natispray
Neos nitro OPT
Niglin
Niglycon
Niong
Niong Retard
Nirmin
Nit-Ret
Nitora
Nitradisc
Nitradisc Pad
Nitradisc TTS
Nitrangin
Nitrek
Nitriderm
Nitriderm TTS
Nitrine-TDC
Nitro Bid
Nitro Dur
Nitro Dur TTS
Nitro Mack Retard
Nitro Retard
Nitro Rorer
Nitro-Bid
Nitro-Dur 10
Nitro-Dur 5
Nitro-Gesanit Retard
Nitro-M-Bid
Nitro-Mack Retard
Nitro-Par
Nitro-Pflaster
Nitro-Span
Nitro-Time
Nitro-bid (TN)
Nitro-dur
Nitro-dur (TN)
Nitro-lent
NitroBid
NitroCor
 
NitroDur
NitroMist
NitroQuick
NitroQuik
Nitroard
Nitrobaat
Nitrobid Oint
Nitrobukal
Nitrocap
NitrocapT.D
NitrocapT.D.
Nitrocard
Nitrocerin
Nitrocine
Nitrocine 5
Nitroclyn
Nitrocontin
Nitrocontin Continus
Nitrocot
Nitroderm
Nitroderm TTS
Nitroderm TTS Ext
Nitroderm TTS-5
Nitrodisc
Nitrodyl
Nitrodyl TTS
Nitrogard
Nitrogard-SR
Nitroglicerina
Nitrogliceryna
Nitroglin
Nitroglycerin
Nitroglycerin (NG)
Nitroglycerin ointment
Nitroglycerin-ACC
Nitroglycerine
Nitroglycerol
Nitroglyn
Nitroject
Nitrol Ointment
Nitrolan
Nitroletten
Nitrolin
Nitrolingual
Nitrolingual Spray
Nitrolowe
Nitromack Retard
Nitromed
Nitromel
Nitromex
Nitromint
Nitromint Aerosol
Nitromint Retard
Nitromist
Nitromist (TN)
Nitronal Aqueous
Nitronet
Nitrong
Nitrong Retard
Nitrong parenteral
Nitrong-SR
Nitropatch
Nitropen
Nitropercuten
Nitroperlinit
Nitroplast
Nitroprol
Nitropront
Nitroprontan
Nitrorectal
Nitroretard
Nitrorex
Nitrospan
Nitrostabilin
Nitrostat
Nitrovis
Nitrozell retard
Nysconitrine
Percutol
Percutol Oint
Percutol Oint.
Perganit
Perglottal
Perlinganit
Plastranit
Polnitrin
Propane-1,2,3-triyl trinitrate
RCRA waste no. P081
Ratiopharm
Rectogesic
SDM No. 17
SK-106N
SK-866
SK-878
Soup
Spirit of glonoin
Susadrin
Suscard
Sustac
Sustak
Sustonit
TNG
Temponitrin
Top-Nitro
Transderm Nitro
Transderm nitro
Transderm-N TTS
Transderm-Nitro TTS
Transderm-nitro
Transderm-nitro (TN)
Transiderm-nitro
Tridil
Tridil sublin
Trinalgon
Trinipatch
Triniplas
Trinitrate, Glyceryl
Trinitrin
Trinitrin Tablets
Trinitrina Erba
Trinitrine
Trinitroglycerin
Trinitroglycerol
Trinitrol
Trinitrolong
Trinitron
Trinitrosan
Turicard
UN0143
UN0144
UN1204
UN3064
UN3319
UNII-G59M7S0WS3
Vascana
Vasoglyn
Vasolator
Vernies
Willong
c0061
nitroglycerin
4
nivolumabapprovedPhase 2326946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
5ImmunoglobulinsPhase 26045
6Antibodies, MonoclonalPhase 23795
7Angiogenesis InhibitorsPhase 24143
8Angiogenesis Modulating AgentsPhase 24072
9AntibodiesPhase 26045

Interventional clinical trials:

idNameStatusNCT IDPhase
1Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for ChoriocarcinomaUnknown statusNCT00294177Phase 4
2Second Curettage in Treating Patients With Persistent Non-Metastatic Gestational Trophoblastic TumorUnknown statusNCT00521118Phase 2
3Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)RecruitingNCT02664961Phase 2
4Nivolumab and Ipilimumab in Treating Patients With Rare TumorsRecruitingNCT02834013Phase 2
5The French National Reference Centre of GTDRecruitingNCT02892877

Search NIH Clinical Center for Placental Site Trophoblastic Tumor


Cochrane evidence based reviews: trophoblastic tumor, placental site

Genetic Tests for Placental Site Trophoblastic Tumor

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Anatomical Context for Placental Site Trophoblastic Tumor

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MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

36
Placenta, Lung, Uterus, Liver, Ovary, Testis, Brain

Publications for Placental Site Trophoblastic Tumor

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Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
Diagnosis and management of a rare case with placental site trophoblastic tumor. (27751424)
2016
2
SALL4 expression in gestational trophoblastic tumors: a useful tool to distinguish choriocarcinoma from placental site trophoblastic tumor and epithelioid trophoblastic tumor. (27068524)
2016
3
Extrauterine Placental Site Trophoblastic Tumor Involving the Vagina. (27513078)
2016
4
Placental site trophoblastic tumor: A review of 108 cases and their implications for prognosis and treatment. (27168005)
2016
5
Imaging and Clinical Data of Placental Site Trophoblastic Tumor: A Case Report. (27679689)
2016
6
Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. (26261623)
2015
7
Placental site trophoblastic tumor presented with vaginal metastasis. (25932270)
2015
8
Single synchronous pulmonary metastasis from placental site trophoblastic tumor and teratoma. (25908040)
2015
9
Placental site trophoblastic tumor: a case report and review of the literature. (26622924)
2015
10
Retrospective analysis of the clinicopathologic and prognostic characteristics of stage I placental site trophoblastic tumor in China. (25572983)
2015
11
Placental site trophoblastic tumor: report of a tertiary center experience. (26775357)
2015
12
Placental site trophoblastic tumor: A case report and literature review. (26361566)
2015
13
Placental-site trophoblastic tumor and fluorine-18- fluorodeoxyglucose positron emission tomography/ computed tomography. (26574698)
2015
14
Placental site trophoblastic tumor and choriocarcinoma: an unusual presentation. (26597227)
2015
15
Placental site trophoblastic tumor on endometrial polyp: a case report. (24654471)
2014
16
Placental site trophoblastic tumor: a case report and review of the literature. (25593955)
2014
17
Exaggerated placental site/placental site trophoblastic tumor: an underestimated risk factor for emergency peripartum hysterectomy. (25551954)
2014
18
Attempted conservative management of a placental site trophoblastic tumor: a case report. (25314886)
2014
19
Placental site trophoblastic tumor: Immunohistochemistry algorithm key to diagnosis and review of literature. (24624322)
2014
20
Lupus nephritis associated with placental site trophoblastic tumor: A case report and review of the literature. (24944882)
2014
21
Unsuccessful planned conservative resection of placental site trophoblastic tumor. (23344410)
2013
22
Placental site trophoblastic tumor, report of a case with unusual presentation. (23478075)
2013
23
Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report. (23688193)
2013
24
Placental site trophoblastic tumor in the pelvic wall: a case report and review of the literature. (24152517)
2013
25
Sonographic characteristics of placental site trophoblastic tumor. (22807194)
2013
26
Diagnosis and treatment of placental site trophoblastic tumor. (23826431)
2013
27
Atypical recurrence of a placental site trophoblastic tumor four years after hysterectomy for benign condition: Case report and review of literature. (24371716)
2013
28
Placental site trophoblastic tumor with metastasis - A case report. (24532939)
2013
29
Long-term outcome of placental site trophoblastic tumor in The Netherlands. (23763007)
2013
30
Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome. (23274560)
2013
31
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. (23040933)
2012
32
Clinical features of 17 cases of placental site trophoblastic tumor. (21862010)
2011
33
Kidney involvement in a patient affected by placental site trophoblastic tumor. (21257242)
2011
34
Two cases of placental site trophoblastic tumor. (22030056)
2011
35
Placental Site Trophoblastic Tumor with lung metastases as cause of death in a young patient: a case report. (22027660)
2011
36
Placental site trophoblastic tumor--a challenging, rare entity. (21199764)
2010
37
Placental site trophoblastic tumor presenting as a friable cervical mass. (21061804)
2010
38
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. (20381116)
2010
39
Expression of glypican 3 in placental site trophoblastic tumor. (20868507)
2010
40
Placental site trophoblastic tumor: lymphatic spread and possible target markers. (19910023)
2010
41
Placental site trophoblastic tumor with unusual presentation in the uterine cervix. (19819607)
2010
42
Exaggerated placental site mimicking placental site trophoblastic tumor: case report and literature review. (21061810)
2010
43
Placental site trophoblastic tumor. (19935163)
2009
44
Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. (19366068)
2009
45
Survival of placental-site trophoblastic tumor patients strongly linked with time since related pregnancy. (19670504)
2009
46
Placental site trophoblastic tumor diagnosed on transvaginal sonography. (19644948)
2009
47
Placental site trophoblastic tumor with multiple metastases and complete response to salvage BEP regimen: a case report and review of the literature. (18506643)
2009
48
Diagnostic evaluation of metastatic placental site trophoblastic tumor. (19622963)
2009
49
Placental site trophoblastic tumor (PSTT) with multiple metastases and extremely poor prognosis. (19856056)
2009
50
Placental site trophoblastic tumor in the ovary of a young child with isosexual precocious puberty. (18671454)
2009

Variations for Placental Site Trophoblastic Tumor

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Expression for genes affiliated with Placental Site Trophoblastic Tumor

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Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

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GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

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Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cellular response to epidermal growth factor stimulusGO:007136410.0EGFR, ERBB2
2ERBB2 signaling pathwayGO:003812810.0EGFR, ERBB2
3ovarian follicle developmentGO:00015419.9INHA, VEGFA
4positive regulation of cell adhesionGO:00457859.7ERBB2, VEGFA
5cell surface receptor signaling pathwayGO:00071669.7EGFR, ERBB2, INHA
6nervous system developmentGO:00073999.4ERBB2, INHA, VEGFA
7regulation of cell motilityGO:20001459.3EGFR, ERBB2
8lung developmentGO:00303249.3EGFR, GPC3, VEGFA
9positive regulation of epithelial cell proliferationGO:00506799.1EGFR, ERBB2, VEGFA
10positive regulation of MAP kinase activityGO:00434069.1EGFR, ERBB2, VEGFA
11positive regulation of protein phosphorylationGO:00019348.9EGFR, ERBB2, VEGFA

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:00047149.3EGFR, ERBB2
2protein heterodimerization activityGO:00469828.6EGFR, ERBB2, INHA, VEGFA

Sources for Placental Site Trophoblastic Tumor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet