MCID: PLC003
MIFTS: 44

Placental Site Trophoblastic Tumor malady

Categories: Rare diseases, Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Placental Site Trophoblastic Tumor

About this section
Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 45NIH Rare Diseases, 47Novoseek, 36MeSH, 65UMLS, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Placental Site Trophoblastic Tumor:

Name: Placental Site Trophoblastic Tumor 10 12 51
Trophoblastic Tumor, Placental Site 36 65
Trophoblastic Tumor Placental Site 45 47
Placental-Site Gestational Trophoblastic Neoplasm 10
 
Placenta Neoplasm 45
Deciduoma 65
Psst 51

Characteristics:

Orphanet epidemiological data:

51
placental site trophoblastic tumor:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Disease Ontology10 DOID:3596
MeSH36 D018245
NCIt42 C3757
Orphanet51 99928
SNOMED-CT59 237252008, 75320001
UMLS via Orphanet66 C0206666
ICD10 via Orphanet28 D39.2
MESH via Orphanet37 D018245
ICD1027 C58
UMLS65 C0206666, C0524541

Summaries for Placental Site Trophoblastic Tumor

About this section
Wikipedia:68 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards based summary: Placental Site Trophoblastic Tumor, also known as trophoblastic tumor, placental site, is related to spondylitis and pancreatitis, and has symptoms including abnormality of the menstrual cycle, spontaneous abortion and uterine neoplasm. An important gene associated with Placental Site Trophoblastic Tumor is INHA (Inhibin Alpha), and among its related pathways are Agrin Interactions at Neuromuscular Junction and Alzheimers Disease Pathway. Affiliated tissues include placenta, liver and lung, and related mouse phenotype cardiovascular system.

Related Diseases for Placental Site Trophoblastic Tumor

About this section

Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1spondylitis30.6EGFR, ERBB2
2pancreatitis10.4
3flat ductal epithelial atypia10.3EGFR, ERBB2
4adenofibroma10.3EGFR, ERBB2
5her2-receptor positive breast cancer10.3EGFR, ERBB2
6situs inversus10.3EGFR, ERBB2
7high molecular weight kininogen deficiency10.3EGFR, ERBB2
8eccrine papillary adenocarcinoma10.3EGFR, ERBB2
9protein-deficiency anemia10.3EGFR, ERBB2
10nasal cavity squamous cell carcinoma10.3EGFR, ERBB2
11gastric cardia carcinoma10.3EGFR, ERBB2
12supernumerary nipples10.3CGB3, EGFR
13mediastinal neurilemmoma10.3EGFR, ERBB2
14lymphoepithelioma-like carcinoma10.3EGFR, ERBB2
15nonsyndromic hereditary sensorineural hearing loss10.3CGB5, ERBB2
16peritoneal cystic mesothelioma10.3EGFR, ERBB2
17cavernous hemangioma10.3EGFR, ERBB2
18scrotum paget's disease10.3EGFR, ERBB2
19alcohol abuse10.3
20hepatitis10.3
21hepatitis b10.3
22infantile myofibromatosis10.3
23goiter10.3
24nodular goiter10.3
25nasal cavity adenocarcinoma10.3EGFR, ERBB2
26ampullary signet ring cell adenocarcinoma10.3EGFR, ERBB2
27epidermal nevus vitamin d resistant rickets10.3EGFR, ERBB2
28lymphatic system cancer10.3EGFR, ERBB2
29sclerosing hemangioma10.2EGFR, ERBB2
30bacterial exanthem10.2EGFR, ERBB2
31progesterone-receptor negative breast cancer10.2EGFR, ERBB2
32eye carcinoma in situ10.2EGFR, ERBB2
33pheochromocytoma10.2
34breast cancer10.2
35cystic fibrosis10.2
36heart disease10.2
37gout10.2
38neuroendocrine tumor10.2
39retinitis10.2
40neuronitis10.2
41multiple endocrine neoplasia10.2
42endotheliitis10.2
43vascular dementia10.2EGFR, ERBB2
44familial cold autoinflammatory syndrome 210.2CGB3, CGB5
45ovary epithelial cancer10.2EGFR, ERBB2
46ovarian wilms' cancer10.2EGFR, ERBB2
47bronchogenic lung adenocarcinoma10.2EGFR, GPC3
48lupus erythematosus10.2EGFR, ERBB2
49ovarian primitive germ cell tumor10.2GPC3, INHA
50paroxysmal choreoathetosis10.2EGFR, ERBB2

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Symptoms for Placental Site Trophoblastic Tumor

About this section

Symptoms:

 51 (show all 9)
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • neoplasms/tumors
  • uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer
  • antenatal period/pregnancy anomalies
  • spontaneous abortions
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Placental Site Trophoblastic Tumor:

(show all 7)
id Description Frequency HPO Source Accession
1 abnormality of the menstrual cycle hallmark (90%) HP:0000140
2 spontaneous abortion hallmark (90%) HP:0005268
3 uterine neoplasm hallmark (90%) HP:0010784
4 neoplasm of the liver occasional (7.5%) HP:0002896
5 neoplasm of the nervous system occasional (7.5%) HP:0004375
6 neoplasm of the lung occasional (7.5%) HP:0100526
7 vaginal neoplasm occasional (7.5%) HP:0100650

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

About this section

Drugs for Placental Site Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Chorionic GonadotropinPhase 4173
2
Nitroglycerinapproved, investigationalPhase 213955-63-04510
Synonyms:
1,2,3-Propanetrioltrinitrate
1,2,3-Propanetriyl nitrate
100292-13-5
105469-31-6
55-63-0
80066-48-4
8013-23-8
9010-02-0
AC1L1IBV
Adesitrin
Aldonitrin
Angibid
Angiolingual
Angiplex
Anglix
Angonist
Angorin
Anogesic
Aquo-Trimitrosan
BIDD:GT0142
BRN 1802063
Blasting gelatin
Blasting oil
Buccal
Buccard
C07455
C3H5N3O9
CCRIS 4089
CHEBI:28787
CHEMBL730
CID4510
CPD-143
Cardabid
Cardamist
Cardinit
Cardiodisco
Cellegesic
Chitamite
Colenitral
Cordipatch
Corditrine
Coro-Nitro
D00515
D005996
DB00727
Dauxona
Deponit
Deponit 5
Deponit TTS 10
Deponit TTS 5
Deponit-5
Diafusor
Discotrine
Dynamite
EINECS 200-240-8
Epinitril
GTN
GTN-Pohl
Gepan Nitroglicerin
Gilucor nitro
Gilustenon
Glonoin
Glycerin trinitrate
Glycerine trinitrate
Glycerintrinitrate
Glycerol trinitrate
Glycerol, nitric acid triester
Glyceroli trinitratis
Glyceroltrinitraat
Glyceroltrinitrat
Glyceryl
Glyceryl nitrate
Glyceryl trinitrate
Glycerylnitrat
Glytrin
HMS2094M15
HSDB 30
Herwicard
Herzer
IMX-150
Klavikordal
LS-7741
Lenitral
Lentonitrina
MED-2002
MQX-503
Mi-Trates
Millisrol
Minitram
Minitran
Minitran (TN)
Minitro
Mionitrat
Myocon
Myoglycerin
Myovin
NG
NITRO IV
NK-843
NTG
Natispray
Neos nitro OPT
Niglin
Niglycon
Niong
Niong Retard
Nirmin
Nit-Ret
Nitora
Nitradisc
Nitradisc Pad
Nitradisc TTS
Nitrangin
Nitrek
Nitriderm
Nitriderm TTS
Nitrine-TDC
Nitro Bid
Nitro Dur
Nitro Dur TTS
Nitro Mack Retard
Nitro Retard
Nitro Rorer
Nitro-Bid
Nitro-Dur 10
Nitro-Dur 5
Nitro-Gesanit Retard
Nitro-M-Bid
Nitro-Mack Retard
Nitro-Par
Nitro-Pflaster
Nitro-Span
Nitro-Time
Nitro-bid
Nitro-bid (TN)
Nitro-dur
Nitro-dur (TN)
Nitro-lent
NitroBid
NitroCor
NitroDur
NitroMist
NitroQuick
 
NitroQuik
Nitroard
Nitrobaat
Nitrobid Oint
Nitrobukal
Nitrocap
NitrocapT.D
NitrocapT.D.
Nitrocard
Nitrocerin
Nitrocine
Nitrocine 5
Nitroclyn
Nitrocontin
Nitrocontin Continus
Nitrocot
Nitroderm
Nitroderm TTS
Nitroderm TTS Ext
Nitroderm TTS-5
Nitrodisc
Nitrodyl
Nitrodyl TTS
Nitrogard
Nitrogard-SR
Nitroglicerina
Nitrogliceryna
Nitroglin
Nitroglycerin
Nitroglycerin (NG)
Nitroglycerin ER
Nitroglycerin Lingual
Nitroglycerin Transdermal Delivery System
Nitroglycerin Transdermal System
Nitroglycerin ointment
Nitroglycerin-ACC
Nitroglycerine
Nitroglycerol
Nitroglyn
Nitroject
Nitrol Ointment
Nitrolan
Nitroletten
Nitrolin
Nitrolingual
Nitrolingual Pumpspray
Nitrolingual Spray
Nitrolowe
Nitromack Retard
Nitromed
Nitromel
Nitromex
Nitromint
Nitromint Aerosol
Nitromint Retard
Nitromist
Nitromist (TN)
Nitronal Aqueous
Nitronet
Nitrong
Nitrong Retard
Nitrong parenteral
Nitrong-SR
Nitropatch
Nitropen
Nitropercuten
Nitroperlinit
Nitroplast
Nitroprol
Nitropront
Nitroprontan
Nitrorectal
Nitroretard
Nitrorex
Nitrospan
Nitrostabilin
Nitrostat
Nitrovis
Nitrozell retard
Nysconitrine
Percutol
Percutol Oint
Percutol Oint.
Perganit
Perglottal
Perlinganit
Plastranit
Polnitrin
Propane-1,2,3-triyl trinitrate
RCRA waste no. P081
Ratiopharm
Rectiv
Rectogesic
SDM No. 17
SK-106N
SK-866
SK-878
Soup
Spirit of glonoin
Susadrin
Suscard
Sustac
Sustak
Sustonit
TNG
Temponitrin
Top-Nitro
Transderm Nitro
Transderm nitro
Transderm-N TTS
Transderm-Nitro TTS
Transderm-nitro
Transderm-nitro (TN)
Transiderm-nitro
Tridil
Tridil sublin
Trinalgon
Trinipatch
Triniplas
Trinitrate, Glyceryl
Trinitrin
Trinitrin Tablets
Trinitrina Erba
Trinitrine
Trinitroglycerin
Trinitroglycerol
Trinitrol
Trinitrolong
Trinitron
Trinitrosan
Turicard
UN0143
UN0144
UN1204
UN3064
UN3319
UNII-G59M7S0WS3
Vascana
Vasoglyn
Vasolator
Vernies
Willong
c0061
nitroglycerin
3
Bevacizumabapproved, investigationalPhase 21875216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
4ImmunoglobulinsPhase 24477
5AntibodiesPhase 24477
6Angiogenesis InhibitorsPhase 23688
7Angiogenesis Modulating AgentsPhase 23611

Interventional clinical trials:

idNameStatusNCT IDPhase
1Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for ChoriocarcinomaNot yet recruitingNCT00294177Phase 4
2Second Curettage in Treating Patients With Persistent Non-Metastatic Gestational Trophoblastic TumorRecruitingNCT00521118Phase 2
3Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)Not yet recruitingNCT02664961Phase 2

Search NIH Clinical Center for Placental Site Trophoblastic Tumor


Cochrane evidence based reviews: trophoblastic tumor, placental site

Genetic Tests for Placental Site Trophoblastic Tumor

About this section

Anatomical Context for Placental Site Trophoblastic Tumor

About this section

MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

33
Placenta, Liver, Lung, Uterus, Cervix, Breast, Brain

Animal Models for Placental Site Trophoblastic Tumor or affiliated genes

About this section

MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.6EGFR, ERBB2, GPC3, INHA, LNPEP, PAM

Publications for Placental Site Trophoblastic Tumor

About this section

Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 158)
idTitleAuthorsYear
1
Lithium therapy in Kleine-Levin syndrome: An open-label, controlled study in 130 patients. (26453648)
2015
2
Effectiveness of Use of Button-Operated Electronic Devices Among Persons With BA!lint Syndrome. (26122689)
2015
3
Erdheim-Chester disease and knee pain in a dialysis patient. (25852919)
2014
4
Hemochromatosis and the heart-Heavier than iron? (24331117)
2014
5
Longitudinal monitoring of the serotonin transporter gene expression to assess major depressive episode evolution. (25592385)
2014
6
Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. (23792957)
2013
7
Abnormalities of brain response during encoding into verbal working memory among euthymic patients with bipolar disorder. (24119150)
2013
8
Helping men cope with penile cancer. (23592452)
2013
9
Comparison of lymphedema in patients with axillary lymph node dissections to those with sentinel lymph node biopsy followed by immediate and delayed ALND. (22157215)
2013
10
Trends in immediate breast reconstruction across insurance groups after enactment of breast cancer legislation. (23585144)
2013
11
SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells. (23079621)
2012
12
Riedel's thyroiditis - a case report with genes' expression studies. (22397327)
2012
13
NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis. (22198715)
2012
14
Relationship between metabolic syndrome and multinodular non-toxic goiter in an inpatient population from a geographic area with moderate iodine deficiency. (21737999)
2012
15
Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4 downregulation and efficient T cell transformation. (21849449)
2011
16
ALK-1-negative anaplastic large cell lymphoma associated with breast implants: a new clinical entity. (21729665)
2011
17
Diffuse xanthomatosis as a presenting feature of multiple myeloma. (20015339)
2010
18
Novel perspectives on drug addiction and reward. (20493904)
2010
19
Cerebro-spinal and renal ochronosis: A rare case report. (23105912)
2010
20
Variable number of tandem repeat polymorphisms (VNTRs) in the ACAN gene associated with pectus excavatum. (21039430)
2010
21
beta- and gamma-catenin expression in oral dysplasia. (18715817)
2009
22
TMP21 transmembrane domain regulates gamma-secretase cleavage. (19710022)
2009
23
Effectiveness of ultrasonographic evaluation of the cranial sutures in children with suspected craniosynostosis. (18941755)
2009
24
Expression and immune effect of toll-like receptor 4 in human trophoblast cells. (19513622)
2009
25
Deletion of 8p23.1 with features of Cornelia de Lange syndrome and congenital diaphragmatic hernia and a review of deletions of 8p23.1 to 8pter? A further locus for Cornelia de Lange syndrome. (18470924)
2008
26
Tubulo-interstitial nephritis with Fanconi syndrome in BehAset disease. (17405783)
2007
27
Cooperative effects of cofilin (ADF) on actin structure suggest allosteric mechanism of cofilin function. (16375920)
2006
28
Adenoviral-mediated gene delivery to trophoblast cells. (16251760)
2006
29
Pseudoaneurysm embolization and vasopressin infusion for lower gastrointestinal bleeding due to recurrence of urinary bladder carcinoma. (16958402)
2006
30
Screening of tumor necrosis factor receptor-associated factor 6 as a candidate gene for inflammatory bowel disease. (16635910)
2006
31
Composition changes in gingival crevicular fluid during orthodontic tooth movement: comparisons between tension and compression sides. (17026508)
2006
32
Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma. (16461357)
2006
33
Long-term and frequent cellular phone use and risk of acoustic neuroma. (17260880)
2006
34
Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease. (15172744)
2004
35
Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma. (15239346)
2004
36
The role of glycation in the pathogenesis of diabetic polyneuropathy. (11724915)
2001
37
A completely foreign receptor can mediate an interferon-gamma-like response. (11574475)
2001
38
Molecular expression analysis of restrictive receptor for interleukin 13, a brain tumor-associated cancer/testis antigen. (10952023)
2000
39
Structure/function studies of human decay-accelerating factor. (11012760)
2000
40
Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons. (10814675)
2000
41
A school-based approach to the control of urinary schistosomiasis and intestinal helminth infections in children in Matuga, Kenya: impact of a two-year chemotherapy programme on prevalence and intensity of infections. (9315040)
1997
42
Activity of ternary gelatinase A-TIMP-2-matrix metallo-proteinase complexes. (7840900)
1994
43
Clear cell basal cell carcinoma: an unusual degenerative variant. (8227606)
1993
44
Paronychia: a sign heralding an exacerbation of pemphigus vulgaris. (8349873)
1993
45
Cyclic AMP increases electrical capacitance of apical membrane of toad urinary bladder. (1725741)
1991
46
Clinical and pathological study of tumor marker in benign prostatic hypertrophy and incidental prostatic cancer]. (1716409)
1991
47
Insulin-like growth factor-binding protein-1 inhibits binding of IGF-I on fetal skin fibroblasts but stimulates their DNA synthesis. (2175183)
1990
48
Induction of matrix Gla protein synthesis during prolonged 1,25-dihydroxyvitamin D3 treatment of osteosarcoma cells. (2108798)
1990
49
Enamel erosion...multiple cases with a common cause (?). (6951962)
1982
50
CHROMOBLASTOMYCOSIS. (14213455)
1964

Variations for Placental Site Trophoblastic Tumor

About this section

Expression for genes affiliated with Placental Site Trophoblastic Tumor

About this section
Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

About this section

GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

About this section

Cellular components related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:00163239.3EGFR, ERBB2

Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1SMAD protein signal transductionGO:00603959.9INHA, LNPEP
2peptide hormone processingGO:00164869.8CGB3, CGB5
3transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.6EGFR, ERBB2
4ERBB2 signaling pathwayGO:00381289.6EGFR, ERBB2
5positive regulation of cell growthGO:00303079.2EGFR, ERBB2
6cell-cell signalingGO:00072678.8CGB3, CGB5, INHA, LNPEP

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:00047169.3EGFR, ERBB2

Sources for Placental Site Trophoblastic Tumor

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet