MCID: PLC003
MIFTS: 51

Placental Site Trophoblastic Tumor malady

Rare diseases, Cancer diseases, Reproductive diseases categories

Summaries for Placental Site Trophoblastic Tumor

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Wikipedia:63 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards based summary: Placental Site Trophoblastic Tumor, also known as trophoblastic tumor placental site, is related to epithelioid trophoblastic tumor and trophoblastic neoplasm, and has symptoms including abnormality of the menstrual cycle, spontaneous abortion and uterine neoplasm. An important gene associated with Placental Site Trophoblastic Tumor is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Alzheimers Disease Pathway and Agrin Interactions at Neuromuscular Junction. The compounds griseofulvin and 11-ketotestosterone have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and liver, and related mouse phenotypes are reproductive system and embryogenesis.

Aliases & Classifications for Placental Site Trophoblastic Tumor

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Placental Site Trophoblastic Tumor, Aliases & Descriptions:

Name: Placental Site Trophoblastic Tumor 9 11 47
Trophoblastic Tumor Placental Site 41 43
Placental-Site Gestational Trophoblastic Neoplasm 9
Trophoblastic Tumor, Placental Site 60
 
Placenta Neoplasm 41
Deciduoma 60
Psst 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

47
placental site trophoblastic tumor:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Adult


External Ids:

Disease Ontology9 DOID:3596
NCIt38 C3757
MeSH33 D018245
Orphanet47 99928
SNOMED-CT55 75320001, 237252008
MESH via Orphanet34 D018245
ICD10 via Orphanet26 D39.2
UMLS via Orphanet61 C0206666
ICD1025 C58

Related Diseases for Placental Site Trophoblastic Tumor

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Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid trophoblastic tumor31.5MCAM
2trophoblastic neoplasm31.2CGA, CGB5
3ectopic pregnancy31.0CGB, CGA, CGB5
4precocious puberty30.9CGB5, CGA
5gestational trophoblastic neoplasm30.7CGB5, CGA, CGB, ALPP
6teratoma30.5GPC3, ALPP, CGB, CGA, CGB5
7choriocarcinoma30.3GPC3, ALPP, KRT18, CGB, CGA, CGB5
8extragonadal germ cell tumor10.5CGB5
9superior vena cava syndrome10.5CGB
10cervicitis10.5
11leiomyoma10.5
12anencephaly10.4CGA
13testicular germ cell tumor10.3
14alopecia10.3
15arteriovenous fistula10.3
16placental abruption10.3
17infertility10.3
18placenta accreta10.3
19alopecia areata10.3
20pneumothorax10.3
21vaginitis10.3
22lupus nephritis10.3
23nonseminomatous germ cell tumor10.3
24nephritis10.3
25proteinuria10.3
26invasive mole10.3
27cryptococcosis10.3CGB5, CGB
28ovarian cyst10.3CGB5, CGA
29ovarian hyperstimulation syndrome10.3CGB5, CGA
30gynecomastia10.3CGA, CGB5
31oligospermia10.3CGB5, CGA
32germ cell cancer10.3ALPP, CGA
33kallmann syndrome10.3CGA, CGB5
34turner syndrome10.3CGB, CGA
35polycystic ovary syndrome10.3CGA, CGB5
36pregnancy loss, recurrent 110.2CGB5, CGA
37leydig cell tumor10.2CGB5, CGA
38leigh syndrome10.2
39thymic carcinoma10.2KRT18, ALPP
40klinefelter's syndrome10.2CGB, CGA
41hyperandrogenism10.2CGB5, CGA
42endodermal sinus tumor10.2ALPP, CGB, CGB5
43gestational trophoblastic tumor10.2CGB, CGA, CGB5
44hyperprolactinemia10.2CGB5, CGA, CGB
45neural tube defects10.2CGB5, CGA, CGB
46chromosomal triplication10.2CGB, CGA, CGB5
47deficiency anemia10.2CGB5, CGB, ALPP
48down syndrome10.2CGB, CGA, CGB5
49dysgerminoma10.2ALPP, CGA, CGB5
50cryptorchidism10.1ALPP, CGA, CGB5

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Symptoms for Placental Site Trophoblastic Tumor

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Symptoms:

 47 (show all 9)
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • neoplasms/tumors
  • uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer
  • antenatal period/pregnancy anomalies
  • spontaneous abortions
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Placental Site Trophoblastic Tumor:

(show all 7)
id Description Frequency HPO Source Accession
1 abnormality of the menstrual cycle hallmark (90%) HP:0000140
2 spontaneous abortion hallmark (90%) HP:0005268
3 uterine neoplasm hallmark (90%) HP:0010784
4 neoplasm of the liver occasional (7.5%) HP:0002896
5 neoplasm of the nervous system occasional (7.5%) HP:0004375
6 neoplasm of the lung occasional (7.5%) HP:0100526
7 vaginal neoplasm occasional (7.5%) HP:0100650

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

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Drug clinical trials:

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Search NIH Clinical Center for Placental Site Trophoblastic Tumor

Genetic Tests for Placental Site Trophoblastic Tumor

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Anatomical Context for Placental Site Trophoblastic Tumor

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MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

31
Placenta, Lung, Liver, Uterus, Cervix, Ovary, Brain, Testis, Lymph node, Kidney, Adrenal gland, Testes

Animal Models for Placental Site Trophoblastic Tumor or affiliated genes

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MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2GPC3, ALPP, ERBB2, EGFR, CGA
2MP:00053808.1GPC3, ALPP, ERBB2, KRT18, EGFR
3MP:00053787.5GPC3, ALPP, ERBB2, KRT18, EGFR, CGA

Publications for Placental Site Trophoblastic Tumor

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Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 154)
idTitleAuthorsYear
1
Lupus nephritis associated with placental site trophoblastic tumor: A case report and review of the literature. (24944882)
2014
2
Unsuccessful planned conservative resection of placental site trophoblastic tumor. (23344410)
2013
3
Diagnosis and treatment of placental site trophoblastic tumor. (23826431)
2013
4
Placental site trophoblastic tumor, report of a case with unusual presentation. (23478075)
2013
5
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. (23040933)
2012
6
Clinical features of 17 cases of placental site trophoblastic tumor. (21862010)
2011
7
Kidney involvement in a patient affected by placental site trophoblastic tumor. (21257242)
2011
8
Two cases of placental site trophoblastic tumor. (22030056)
2011
9
Placental site trophoblastic tumor--a challenging, rare entity. (21199764)
2010
10
Placental site trophoblastic tumor presenting as a friable cervical mass. (21061804)
2010
11
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. (20381116)
2010
12
Placental site trophoblastic tumor: lymphatic spread and possible target markers. (19910023)
2010
13
Placental site trophoblastic tumor. (19935163)
2009
14
Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. (19366068)
2009
15
Survival of placental-site trophoblastic tumor patients strongly linked with time since related pregnancy. (19670504)
2009
16
Placental-site trophoblastic tumors: a case of resistant pulmonary metastasis. (18227827)
2008
17
Absence of Y chromosome in human placental site trophoblastic tumor. (17643092)
2007
18
Fertility sparing therapy in a patient with placental site trophoblastic tumor: a case report. (17007914)
2006
19
Exclusion of lung metastases in placental site trophoblastic tumor using [18F]fluorodeoxyglucose positron emission tomography: a case report. (16051337)
2005
20
Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature. (15958158)
2005
21
Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor. (16127165)
2005
22
p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. (15316317)
2004
23
Placental site trophoblastic tumor in a postmenopausal female--a case report. (15099979)
2004
24
Placental site trophoblastic tumor: an overview. (15457847)
2004
25
Placental site trophoblastic tumor of the uterine cervix occurring from undetermined antecedent pregnancy. (15009614)
2004
26
Ultrasound diagnosis of uterine arteriovenous fistula associated with placental site trophoblastic tumor. (12808680)
2003
27
Adrenal metastatic placental site trophoblastic tumor. Case report. (12744102)
2003
28
Placental site trophoblastic tumor. (12832940)
2003
29
Successful management of metastatic placental site trophoblastic tumor with multiple pulmonary resections. (12468357)
2002
30
Placental site trophoblastic tumor (PSTT) in mother and child: first report of PSTT in infancy. (11836719)
2002
31
Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center. (11520134)
2001
32
Spontaneous uterine perforation mimicking ectopic pregnancy as the initial presentation of placental site trophoblastic tumor. (11768287)
2001
33
Prolonged remission of recurrent, metastatic placental site trophoblastic tumor after chemotherapy. (10620452)
2000
34
Placental site trophoblastic tumor. Clinical and pathological report of two cases. (11173663)
2000
35
Failure of high-dose chemotherapy with peripheral blood stem cell support for refractory placental site trophoblastic tumor. (10087421)
1999
36
MR appearance of placental site trophoblastic tumor: a report of three cases. (9456970)
1998
37
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
38
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
39
Metastatic placental site trophoblastic tumor: long-term remission in a patient treated with EMA/CO chemotherapy. (9454662)
1998
40
Unusual endovaginal ultrasonography and magnetic resonance imaging of placental site trophoblastic tumor. (8141195)
1994
41
Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. (7691711)
1993
42
Metastasizing placental site trophoblastic tumor. An immunohistochemical and flow cytometric study of two cases. (8396853)
1993
43
Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor. (11576278)
1992
44
Erythrocytosis associated with a placental-site trophoblastic tumor. (1314361)
1992
45
Placental site trophoblastic tumor associated with immature ovarian teratoma. (1972122)
1990
46
Sonographic appearance of placental site trophoblastic tumor. (2170669)
1990
47
Clinical characteristics of placental site trophoblastic tumor (PSTT). (2842238)
1988
48
Malignant placental site trophoblastic tumor. (2991836)
1985
49
Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. (6329973)
1984
50
Placental site trophoblastic tumor of the uterus: an ultrastructural and immunohistochemical study. (6091306)
1984

Variations for Placental Site Trophoblastic Tumor

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Expression for genes affiliated with Placental Site Trophoblastic Tumor

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Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

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Pathways related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5EGFR, ERBB2
29.5ERBB2, EGFR
39.5EGFR, ERBB2
4
Show member pathways
9.5EGFR, ERBB2
59.5ERBB2, EGFR
6
Show member pathways
9.2CGB5, CGA, CGB
7
Show member pathways
9.2ERBB2, EGFR, CGA
89.1ERBB2, GPC3, EGFR

Compounds for genes affiliated with Placental Site Trophoblastic Tumor

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Compounds related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1griseofulvin43 1210.9KRT18, CGA
211-ketotestosterone439.9CGB5, CGA
3ag 1478 hydrochloride599.8ERBB2, EGFR
4iressa599.8ERBB2, EGFR
5ag 490599.8ERBB2, EGFR
6pd158780439.8ERBB2, EGFR
7afatinib49 1210.8EGFR, ERBB2
8jnj 28871063 hydrochloride599.8ERBB2, EGFR
9pertuzumab43 49 1211.7ERBB2, EGFR
10oestriol439.6CGB5, CGB, CGA
11ctp439.6CGA, CGB5, CGB
12clomiphene citrate439.6CGB5, CGA, CGB
13anastrozole43 49 1211.6CGA, EGFR, ERBB2
14ifosfamide43 1210.6CGB, CGA, CGB5
15letrozole43 49 59 1212.5EGFR, ERBB2, CGA
16fulvestrant43 49 28 1212.5ERBB2, EGFR, KRT18
17hrgbeta1439.5EGFR, ERBB2
18quinazoline439.5EGFR, ERBB2
19bleomycin43 1210.5CGA, CGB5, CGB
20androstenedione43 2410.4CGA, CGB5, CGB
21organon439.4CGB5, CGA
22cetrorelix43 28 1211.4EGFR, CGB5, CGA
23tetracycline43 1210.3ERBB2, KRT18, EGFR
24carboplatin43 49 1211.3EGFR, ERBB2, CGA
25mifepristone43 28 59 1212.3CGB, CGB5, CGA
26pki-166439.2ERBB2, EGFR
27gnrh439.1ERBB2, CGB5, CGB, CGA
28methotrexate49 43 1211.1ERBB2, CGA, CGB5, CGB
29etoposide43 49 59 1212.1ERBB2, CGB, CGA, CGB5
30dmso439.0ALPP, KRT18, CGA, CGB5
31leucovorin43 49 1211.0CGB, CGB5, EGFR, ERBB2
32ascorbic acid43 2410.0ALPP, KRT18, CGA, CGB5
33folate438.9ERBB2, CGA, CGB5, ALPP
34cyclophosphamide43 49 1210.8ERBB2, CGA, CGB5, CGB, KRT18
35alanine438.8CGA, ERBB2, ALPP, KRT18, CGB
36creatinine438.7CGB, ALPP, KRT18, CGB5, CGA
37doxorubicin43 49 1210.6EGFR, CGB5, CGA, KRT18, ERBB2
38genistein43 28 59 2 24 1213.6ALPP, ERBB2, EGFR, CGB5
39pge2438.5EGFR, CGA, CGB5, ALPP
40progestin438.5ALPP, CGB5, CGA, EGFR, ERBB2
41tamoxifen43 49 28 1211.4CGB5, ERBB2, ALPP, EGFR, CGA
42cycloheximide438.4CGA, CGB5, ERBB2, EGFR, ALPP
43lactate438.3KRT18, CGB5, CGA, CGB, ALPP, ERBB2
44progesterone43 28 59 24 1212.3CGB5, CGB, EGFR, ERBB2, KRT18, CGA
45cisplatin43 49 59 1211.1CGB, CGA, CGB5, ALPP, ERBB2, EGFR
46paraffin438.1ALPP, KRT18, EGFR, CGA, CGB5, ERBB2
47serine438.0EGFR, CGA, CGB5, KRT18, ALPP, ERBB2
48testosterone43 59 24 1210.8ALPP, ERBB2, KRT18, EGFR, CGB, CGA
49vegf437.8CGB5, CGA, CGB, EGFR, KRT18, ERBB2
50estrogen437.8EGFR, ALPP, CGB, CGA, CGB5, ERBB2

GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

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Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:00164869.8CGB, CGA
2positive regulation of epithelial cell proliferationGO:00506799.5EGFR, ERBB2
3positive regulation of MAP kinase activityGO:00434069.2EGFR, ERBB2
4anatomical structure morphogenesisGO:00096538.9GPC3, KRT18, MCAM
5signal transductionGO:00071658.7CGA, ERBB2, EGFR, CGB

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00050069.5EGFR, ERBB2
2protein phosphatase bindingGO:00199039.5EGFR, ERBB2
3receptor signaling protein tyrosine kinase activityGO:00047169.4EGFR, ERBB2
4transmembrane receptor protein tyrosine kinase activityGO:00047149.2EGFR, ERBB2

Products for genes affiliated with Placental Site Trophoblastic Tumor

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Sources for Placental Site Trophoblastic Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet