PSST
MCID: PLC003
MIFTS: 47

Placental Site Trophoblastic Tumor (PSST) malady

Categories: Rare diseases, Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Placental Site Trophoblastic Tumor

About this section
Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Placental Site Trophoblastic Tumor:

Name: Placental Site Trophoblastic Tumor 11 54 13
Trophoblastic Tumor, Placental Site 39 68
Trophoblastic Tumor Placental Site 48 50
Placental-Site Gestational Trophoblastic Neoplasm 11
 
Placenta Neoplasm 48
Deciduoma 68
Psst 54

Characteristics:

Orphanet epidemiological data:

54
placental site trophoblastic tumor:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Disease Ontology11 DOID:3596
MeSH39 D018245
NCIt45 C3757
Orphanet54 ORPHA99928
SNOMED-CT62 237252008, 75320001
MESH via Orphanet40 D018245
ICD10 via Orphanet31 D39.2
UMLS via Orphanet69 C0206666
ICD1030 C58

Summaries for Placental Site Trophoblastic Tumor

About this section
Wikipedia:71 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards based summary: Placental Site Trophoblastic Tumor, also known as trophoblastic tumor, placental site, is related to choriocarcinoma and liddle syndrome, scnn1g-related, and has symptoms including Array, Array and Array. An important gene associated with Placental Site Trophoblastic Tumor is INHA (Inhibin Alpha Subunit), and among its related pathways are Signaling events mediated by TCPTP and Aryl Hydrocarbon Receptor. Affiliated tissues include placenta, uterus and lung, and related mouse phenotypes are Decreased viability with paclitaxel and cardiovascular system.

Related Diseases for Placental Site Trophoblastic Tumor

About this section

Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1choriocarcinoma10.2
2liddle syndrome, scnn1g-related10.2EGFR, VEGFA
3mucinous cystadenocarcinoma10.2CSH1, INHA
4spastic paraplegia 110.1EGFR, VEGFA
5pineal region mature teratoma10.1EGFR, ERBB2
6novak syndrome10.1CGB5, ERBB2
7triple-receptor negative breast cancer10.1EGFR, ERBB2
8tumor of exocrine pancreas10.1EGFR, VEGFA
9skin sarcoma10.1EGFR, ERBB2
10cervical lymphoepithelioma-like carcinoma10.1EGFR, ERBB2
11epithelioid trophoblastic tumor10.1
12benign familial neonatal epilepsy10.1EGFR, VEGFA
13nervous system hibernoma10.1EGFR, ERBB2
14basaloid squamous cell carcinoma10.1EGFR, ERBB2
15combined t cell and b cell immunodeficiency10.1EGFR, ERBB2
16anomalous left coronary artery from the pulmonary artery10.1EGFR, ERBB2
17reactive arthritis10.1EGFR, ERBB2
18prostate signet ring cell adenocarcinoma10.1EGFR, ERBB2
19growth retardation hydrocephaly lung hypoplasia10.1ERBB2, INHA
20anus adenocarcinoma10.1EGFR, ERBB2
21teratoma10.1
22spongiotic dermatitis10.1EGFR, ERBB2
23sclerosing hemangioma10.1EGFR, ERBB2
24vascular hemostatic disease10.0EGFR, ERBB2
25anaerobic meningitis10.0EGFR, VEGFA
26retinal disease10.0EGFR, ERBB2
27spastic diplegia infantile type10.0EGFR, ERBB2
28gestational trophoblastic neoplasm10.0
29trophoblastic neoplasm10.0
30fallopian tube carcinosarcoma10.0ERBB2, VEGFA
31leigh syndrome10.0
32ectopic pregnancy10.0
33leiomyoma10.0
34vaginitis10.0
35cervicitis10.0
36his bundle tachycardia10.0EGFR, ERBB2
37estrogen-receptor positive breast cancer10.0EGFR, ERBB2
38immunodeficiency due to a late component of complement deficiency9.9EGFR, ERBB2, VEGFA
39multinodular goiter9.9EGFR, ERBB2, VEGFA
40dental caries9.9EGFR, ERBB2, VEGFA
41nasal cavity disease9.9EGFR, ERBB2, VEGFA
42uvula cancer9.9EGFR, ERBB2, VEGFA
43pearson syndrome9.9EGFR, ERBB2, VEGFA
44trachea squamous cell carcinoma9.9EGFR, ERBB2, VEGFA
45pulmonary fibrosis and/or bone marrow failure, telomere-related, 19.9EGFR, ERBB2, VEGFA
46bardet-biedl syndrome9.9EGFR, ERBB2, VEGFA
47malignant pleural solitary fibrous tumor9.9EGFR, ERBB2, VEGFA
48nevoid hypermelanosis, linear and whorled9.9EGFR, ERBB2, VEGFA
49placenta praevia9.9EGFR, ERBB2, VEGFA
50glucose-6-phosphate translocase deficiency9.9EGFR, ERBB2, VEGFA

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Symptoms & Phenotypes for Placental Site Trophoblastic Tumor

About this section

Human phenotypes related to Placental Site Trophoblastic Tumor:

 54 64
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 amenorrhea64 54 Very frequent (99-80%) HP:0000141
2 spontaneous abortion64 54 Very frequent (99-80%) HP:0005268
3 low maternal serum chorionic gonadotropin64 54 Very frequent (99-80%) HP:0011434
4 metrorrhagia64 54 Very frequent (99-80%) HP:0100608

GenomeRNAi Phenotypes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00293-A9.8EGFR, ERBB2

MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1EGFR, ERBB2, GPC3, INHA, LNPEP, VEGFA
2MP:00053817.8EGFR, ERBB2, GPC3, INHA, VEGFA

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

About this section

Drugs for Placental Site Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Chorionic GonadotropinPhase 4196
2
Bevacizumabapproved, investigationalPhase 22020216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
3
Nitroglycerinapproved, investigationalPhase 215655-63-04510
Synonyms:
1,2,3-Propanetrioltrinitrate
1,2,3-Propanetriyl nitrate
100292-13-5
105469-31-6
55-63-0
80066-48-4
8013-23-8
9010-02-0
AC1L1IBV
Adesitrin
Aldonitrin
Angibid
Angiolingual
Angiplex
Anglix
Angonist
Angorin
Anogesic
Aquo-Trimitrosan
BIDD:GT0142
BRN 1802063
Blasting gelatin
Blasting oil
Buccal
Buccard
C07455
C3H5N3O9
CCRIS 4089
CHEBI:28787
CHEMBL730
CID4510
CPD-143
Cardabid
Cardamist
Cardinit
Cardiodisco
Cellegesic
Chitamite
Colenitral
Cordipatch
Corditrine
Coro-Nitro
D00515
D005996
DB00727
Dauxona
Deponit
Deponit 5
Deponit TTS 10
Deponit TTS 5
Deponit-5
Diafusor
Discotrine
Dynamite
EINECS 200-240-8
Epinitril
GTN
GTN-Pohl
Gepan Nitroglicerin
Gilucor nitro
Gilustenon
Glonoin
Glycerin trinitrate
Glycerine trinitrate
Glycerintrinitrate
Glycerol trinitrate
Glycerol, nitric acid triester
Glyceroli trinitratis
Glyceroltrinitraat
Glyceroltrinitrat
Glyceryl
Glyceryl nitrate
Glyceryl trinitrate
Glycerylnitrat
Glytrin
HMS2094M15
HSDB 30
Herwicard
Herzer
IMX-150
Klavikordal
LS-7741
Lenitral
Lentonitrina
MED-2002
MQX-503
Mi-Trates
Millisrol
Minitram
Minitran
Minitran (TN)
Minitro
Mionitrat
Myocon
Myoglycerin
Myovin
NG
NITRO IV
NK-843
NTG
Natispray
Neos nitro OPT
Niglin
Niglycon
Niong
Niong Retard
Nirmin
Nit-Ret
Nitora
Nitradisc
Nitradisc Pad
Nitradisc TTS
Nitrangin
Nitrek
Nitriderm
Nitriderm TTS
Nitrine-TDC
Nitro Bid
Nitro Dur
Nitro Dur TTS
Nitro Mack Retard
Nitro Retard
Nitro Rorer
Nitro-Bid
Nitro-Dur 10
Nitro-Dur 5
Nitro-Gesanit Retard
Nitro-M-Bid
Nitro-Mack Retard
Nitro-Par
Nitro-Pflaster
Nitro-Span
Nitro-Time
Nitro-bid (TN)
Nitro-dur
Nitro-dur (TN)
Nitro-lent
NitroBid
NitroCor
 
NitroDur
NitroMist
NitroQuick
NitroQuik
Nitroard
Nitrobaat
Nitrobid Oint
Nitrobukal
Nitrocap
NitrocapT.D
NitrocapT.D.
Nitrocard
Nitrocerin
Nitrocine
Nitrocine 5
Nitroclyn
Nitrocontin
Nitrocontin Continus
Nitrocot
Nitroderm
Nitroderm TTS
Nitroderm TTS Ext
Nitroderm TTS-5
Nitrodisc
Nitrodyl
Nitrodyl TTS
Nitrogard
Nitrogard-SR
Nitroglicerina
Nitrogliceryna
Nitroglin
Nitroglycerin
Nitroglycerin (NG)
Nitroglycerin ointment
Nitroglycerin-ACC
Nitroglycerine
Nitroglycerol
Nitroglyn
Nitroject
Nitrol Ointment
Nitrolan
Nitroletten
Nitrolin
Nitrolingual
Nitrolingual Spray
Nitrolowe
Nitromack Retard
Nitromed
Nitromel
Nitromex
Nitromint
Nitromint Aerosol
Nitromint Retard
Nitromist
Nitromist (TN)
Nitronal Aqueous
Nitronet
Nitrong
Nitrong Retard
Nitrong parenteral
Nitrong-SR
Nitropatch
Nitropen
Nitropercuten
Nitroperlinit
Nitroplast
Nitroprol
Nitropront
Nitroprontan
Nitrorectal
Nitroretard
Nitrorex
Nitrospan
Nitrostabilin
Nitrostat
Nitrovis
Nitrozell retard
Nysconitrine
Percutol
Percutol Oint
Percutol Oint.
Perganit
Perglottal
Perlinganit
Plastranit
Polnitrin
Propane-1,2,3-triyl trinitrate
RCRA waste no. P081
Ratiopharm
Rectogesic
SDM No. 17
SK-106N
SK-866
SK-878
Soup
Spirit of glonoin
Susadrin
Suscard
Sustac
Sustak
Sustonit
TNG
Temponitrin
Top-Nitro
Transderm Nitro
Transderm nitro
Transderm-N TTS
Transderm-Nitro TTS
Transderm-nitro
Transderm-nitro (TN)
Transiderm-nitro
Tridil
Tridil sublin
Trinalgon
Trinipatch
Triniplas
Trinitrate, Glyceryl
Trinitrin
Trinitrin Tablets
Trinitrina Erba
Trinitrine
Trinitroglycerin
Trinitroglycerol
Trinitrol
Trinitrolong
Trinitron
Trinitrosan
Turicard
UN0143
UN0144
UN1204
UN3064
UN3319
UNII-G59M7S0WS3
Vascana
Vasoglyn
Vasolator
Vernies
Willong
c0061
nitroglycerin
4
nivolumabapprovedPhase 2424946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
5ImmunoglobulinsPhase 26394
6Antibodies, MonoclonalPhase 24039
7Angiogenesis InhibitorsPhase 24257
8Angiogenesis Modulating AgentsPhase 24185
9AntibodiesPhase 26394

Interventional clinical trials:

idNameStatusNCT IDPhase
1Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for ChoriocarcinomaUnknown statusNCT00294177Phase 4
2Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic TumorsCompletedNCT00521118Phase 2
3Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)RecruitingNCT02664961Phase 2
4Nivolumab and Ipilimumab in Treating Patients With Rare TumorsRecruitingNCT02834013Phase 2
5The French National Reference Centre of GTDRecruitingNCT02892877

Search NIH Clinical Center for Placental Site Trophoblastic Tumor


Cochrane evidence based reviews: trophoblastic tumor, placental site

Genetic Tests for Placental Site Trophoblastic Tumor

About this section

Anatomical Context for Placental Site Trophoblastic Tumor

About this section

MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

36
Placenta, Uterus, Lung, Ovary, Cervix, Testis, Brain

Publications for Placental Site Trophoblastic Tumor

About this section

Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
SALL4 expression in gestational trophoblastic tumors: a useful tool to distinguish choriocarcinoma from placental site trophoblastic tumor and epithelioid trophoblastic tumor. (27068524)
2016
2
Placental site trophoblastic tumor: A review of 108 cases and their implications for prognosis and treatment. (27168005)
2016
3
Diagnosis and management of a rare case with placental site trophoblastic tumor. (27751424)
2016
4
Imaging and Clinical Data of Placental Site Trophoblastic Tumor: A Case Report. (27679689)
2016
5
Extrauterine Placental Site Trophoblastic Tumor Involving the Vagina. (27513078)
2016
6
Placental site trophoblastic tumor and choriocarcinoma: an unusual presentation. (26597227)
2015
7
Placental site trophoblastic tumor: report of a tertiary center experience. (26775357)
2015
8
Placental site trophoblastic tumor: a case report and review of the literature. (26622924)
2015
9
Placental site trophoblastic tumor: A case report and literature review. (26361566)
2015
10
Retrospective analysis of the clinicopathologic and prognostic characteristics of stage I placental site trophoblastic tumor in China. (25572983)
2015
11
Placental site trophoblastic tumor presented with vaginal metastasis. (25932270)
2015
12
Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. (26261623)
2015
13
Placental-site trophoblastic tumor and fluorine-18- fluorodeoxyglucose positron emission tomography/ computed tomography. (26574698)
2015
14
Single synchronous pulmonary metastasis from placental site trophoblastic tumor and teratoma. (25908040)
2015
15
Attempted conservative management of a placental site trophoblastic tumor: a case report. (25314886)
2014
16
Exaggerated placental site/placental site trophoblastic tumor: an underestimated risk factor for emergency peripartum hysterectomy. (25551954)
2014
17
Placental site trophoblastic tumor: Immunohistochemistry algorithm key to diagnosis and review of literature. (24624322)
2014
18
Placental site trophoblastic tumor: a case report and review of the literature. (25593955)
2014
19
Lupus nephritis associated with placental site trophoblastic tumor: A case report and review of the literature. (24944882)
2014
20
Placental site trophoblastic tumor on endometrial polyp: a case report. (24654471)
2014
21
Sonographic characteristics of placental site trophoblastic tumor. (22807194)
2013
22
Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report. (23688193)
2013
23
Placental site trophoblastic tumor in the pelvic wall: a case report and review of the literature. (24152517)
2013
24
Unsuccessful planned conservative resection of placental site trophoblastic tumor. (23344410)
2013
25
Placental site trophoblastic tumor, report of a case with unusual presentation. (23478075)
2013
26
Placental site trophoblastic tumor with metastasis - A case report. (24532939)
2013
27
Diagnosis and treatment of placental site trophoblastic tumor. (23826431)
2013
28
Atypical recurrence of a placental site trophoblastic tumor four years after hysterectomy for benign condition: Case report and review of literature. (24371716)
2013
29
Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome. (23274560)
2013
30
Long-term outcome of placental site trophoblastic tumor in The Netherlands. (23763007)
2013
31
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. (23040933)
2012
32
Placental Site Trophoblastic Tumor with lung metastases as cause of death in a young patient: a case report. (22027660)
2011
33
Two cases of placental site trophoblastic tumor. (22030056)
2011
34
Clinical features of 17 cases of placental site trophoblastic tumor. (21862010)
2011
35
Kidney involvement in a patient affected by placental site trophoblastic tumor. (21257242)
2011
36
Placental site trophoblastic tumor: lymphatic spread and possible target markers. (19910023)
2010
37
Placental site trophoblastic tumor--a challenging, rare entity. (21199764)
2010
38
Placental site trophoblastic tumor with unusual presentation in the uterine cervix. (19819607)
2010
39
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. (20381116)
2010
40
Expression of glypican 3 in placental site trophoblastic tumor. (20868507)
2010
41
Exaggerated placental site mimicking placental site trophoblastic tumor: case report and literature review. (21061810)
2010
42
Placental site trophoblastic tumor presenting as a friable cervical mass. (21061804)
2010
43
Diagnostic evaluation of metastatic placental site trophoblastic tumor. (19622963)
2009
44
Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. (19366068)
2009
45
Placental site trophoblastic tumor. (19935163)
2009
46
Placental site trophoblastic tumor with multiple metastases and complete response to salvage BEP regimen: a case report and review of the literature. (18506643)
2009
47
Placental site trophoblastic tumor (PSTT) with multiple metastases and extremely poor prognosis. (19856056)
2009
48
Survival of placental-site trophoblastic tumor patients strongly linked with time since related pregnancy. (19670504)
2009
49
Placental site trophoblastic tumor diagnosed on transvaginal sonography. (19644948)
2009
50
Placental site trophoblastic tumor in the ovary of a young child with isosexual precocious puberty. (18671454)
2009

Variations for Placental Site Trophoblastic Tumor

About this section

Expression for genes affiliated with Placental Site Trophoblastic Tumor

About this section
Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

About this section

Pathways related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.3EGFR, VEGFA
29.3EGFR, VEGFA
39.1EGFR, ERBB2
49.1EGFR, ERBB2
59.1EGFR, ERBB2
69.1EGFR, ERBB2
78.8CSH1, EGFR, VEGFA
8
Show member pathways
8.8EGFR, ERBB2, GPC3
9
Show member pathways
8.5EGFR, ERBB2, VEGFA
10
Show member pathways
8.5EGFR, ERBB2, VEGFA
118.5EGFR, ERBB2, VEGFA
128.5EGFR, ERBB2, VEGFA
138.1EGFR, ERBB2, GPC3, VEGFA
14
Show member pathways
8.1CGB5, EGFR, ERBB2, VEGFA

GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

About this section

Cellular components related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.2CGB5, CSH1, EGFR, GPC3, INHA, LNPEP

Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1ovarian follicle developmentGO:000154110.2INHA, VEGFA
2cell-cell signalingGO:000726710.0CGB5, INHA, LNPEP
3cellular response to epidermal growth factor stimulusGO:00713649.8EGFR, ERBB2
4cellular response to growth factor stimulusGO:00713639.8EGFR, ERBB2
5ERBB2 signaling pathwayGO:00381289.8EGFR, ERBB2
6negative regulation of ERBB signaling pathwayGO:19011859.8EGFR, ERBB2
7regulation of cell motilityGO:20001459.8EGFR, ERBB2
8regulation of ERK1 and ERK2 cascadeGO:00703729.8EGFR, ERBB2
9positive regulation of cell adhesionGO:00457859.7ERBB2, VEGFA
10lung developmentGO:00303249.7EGFR, GPC3, VEGFA
11cell surface receptor signaling pathwayGO:00071669.5EGFR, ERBB2, INHA
12positive regulation of epithelial cell proliferationGO:00506799.2EGFR, ERBB2, VEGFA
13positive regulation of MAP kinase activityGO:00434069.2EGFR, ERBB2, VEGFA
14positive regulation of protein phosphorylationGO:00019349.2EGFR, ERBB2, VEGFA
15regulation of transcription from RNA polymerase II promoterGO:00063578.1CGB5, EGFR, ERBB2, VEGFA

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1signal transducer, downstream of receptor, with protein tyrosine kinase activityGO:00047169.6EGFR, ERBB2
2transmembrane receptor protein tyrosine kinase activityGO:00047149.1EGFR, ERBB2
3protein heterodimerization activityGO:00469828.6EGFR, ERBB2, INHA, VEGFA

Sources for Placental Site Trophoblastic Tumor

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet