MCID: PLC003
MIFTS: 46

Placental Site Trophoblastic Tumor

Categories: Rare diseases, Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Placental Site Trophoblastic Tumor

MalaCards integrated aliases for Placental Site Trophoblastic Tumor:

Name: Placental Site Trophoblastic Tumor 12 55 14
Trophoblastic Tumor, Placental Site 41 69
Trophoblastic Tumor Placental Site 49 51
Placental-Site Gestational Trophoblastic Neoplasm 12
Placenta Neoplasm 49
Deciduoma 69
Psst 55

Characteristics:

Orphanet epidemiological data:

55
placental site trophoblastic tumor
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:3596
MeSH 41 D018245
NCIt 46 C3757
SNOMED-CT 64 237252008 75320001
Orphanet 55 ORPHA99928
MESH via Orphanet 42 D018245
UMLS via Orphanet 70 C0206666
ICD10 via Orphanet 33 D39.2
ICD10 32 C58

Summaries for Placental Site Trophoblastic Tumor

MalaCards based summary : Placental Site Trophoblastic Tumor, also known as trophoblastic tumor, placental site, is related to ectopic pregnancy and epithelioid trophoblastic tumor, and has symptoms including amenorrhea, spontaneous abortion and low maternal serum chorionic gonadotropin. An important gene associated with Placental Site Trophoblastic Tumor is INHA (Inhibin Alpha Subunit), and among its related pathways/superpathways are Peptide hormone metabolism and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Chorionic Gonadotropin and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

Related Diseases for Placental Site Trophoblastic Tumor

Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 ectopic pregnancy 30.3 CGB3 CGB5
2 epithelioid trophoblastic tumor 29.5 CGB3 CSH1 INHA SALL4
3 trophoblastic neoplasm 29.3 CSH1 INHA LNPEP
4 choriocarcinoma 28.7 CGB3 CGB5 CSH1 GPC3 LNPEP
5 gestational trophoblastic tumor 11.8
6 hydatidiform mole, recurrent, 1 10.2 CGB3 CGB5
7 teratoma 10.1
8 germ cells tumors 10.1
9 leigh syndrome 10.1
10 endodermal sinus tumor 10.1 CGB3 SALL4
11 gestational trophoblastic neoplasm 10.1
12 testicular cancer 10.1 CGB3 CGB5
13 leiomyoma 10.1
14 vaginitis 10.1
15 cervicitis 10.1
16 breast metaplastic carcinoma 10.0 CSH1 EGFR
17 placenta disease 10.0 CGB3 CSH1
18 ovarian endodermal sinus tumor 9.9 GPC3 SALL4
19 seminoma 9.9 CGB3 CGB5 INHA
20 ovarian primitive germ cell tumor 9.9 GPC3 SALL4
21 cataract 5, multiple types 9.9
22 suppressor of tumorigenicity 3 9.9
23 testicular germ cell tumor 9.9
24 testicular germ cell tumor 1 9.9
25 alopecia 9.9
26 arteriovenous fistula 9.9
27 amenorrhea 9.9
28 pneumothorax 9.9
29 placenta accreta 9.9
30 infertility 9.9
31 ovarian germ cell teratoma 9.9
32 placental abruption 9.9
33 alopecia areata 9.9
34 nonseminomatous germ cell tumor 9.9
35 precocious puberty 9.9
36 mixed germ cell tumor 9.9
37 invasive mole 9.9
38 testicular yolk sac tumor 9.9 GPC3 SALL4
39 intrahepatic cholangiocarcinoma 9.7 EGFR GPC3
40 endometrial adenocarcinoma 9.7 EGFR LNPEP
41 gastrointestinal system cancer 9.6 EGFR GPC3

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to Placental Site Trophoblastic Tumor

Symptoms & Phenotypes for Placental Site Trophoblastic Tumor

Human phenotypes related to Placental Site Trophoblastic Tumor:

55 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 amenorrhea 55 31 hallmark (90%) Very frequent (99-80%) HP:0000141
2 spontaneous abortion 55 31 hallmark (90%) Very frequent (99-80%) HP:0005268
3 low maternal serum chorionic gonadotropin 55 31 hallmark (90%) Very frequent (99-80%) HP:0011434
4 metrorrhagia 55 31 hallmark (90%) Very frequent (99-80%) HP:0100608

GenomeRNAi Phenotypes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.44 EGFR CGB3 CGB5
2 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.44 EGFR
3 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.44 EGFR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.44 EGFR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.44 EGFR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.44 CGB3 CGB5
7 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.44 CGB3 CGB5
8 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.44 EGFR
9 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.44 EGFR

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

Drugs for Placental Site Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Chorionic Gonadotropin Phase 4
2
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2
3
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
5
leucovorin Approved, Nutraceutical Phase 2, Phase 3 58-05-9 143 6006
6 Antidotes Phase 2, Phase 3
7 Antimetabolites Phase 2, Phase 3
8 Antimetabolites, Antineoplastic Phase 2, Phase 3
9 Antirheumatic Agents Phase 2, Phase 3
10 Dermatologic Agents Phase 2, Phase 3
11 Folic Acid Antagonists Phase 2, Phase 3
12 Hematinics Phase 2, Phase 3
13 Immunosuppressive Agents Phase 2, Phase 3
14 Micronutrients Phase 2, Phase 3
15 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
16 Protective Agents Phase 2, Phase 3
17 Trace Elements Phase 2, Phase 3
18 Vitamin B Complex Phase 2, Phase 3
19 Vitamins Phase 2, Phase 3
20 Folate Nutraceutical Phase 2, Phase 3
21 Vitamin B9 Nutraceutical Phase 2, Phase 3
22
Bevacizumab Approved, Investigational Phase 2 216974-75-3
23
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
24
nivolumab Approved Phase 2 946414-94-4
25 Angiogenesis Inhibitors Phase 2
26 Angiogenesis Modulating Agents Phase 2
27 Antibodies Phase 2
28 Antibodies, Monoclonal Phase 2
29 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177 Phase 4
2 Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia Not yet recruiting NCT03280979 Phase 2, Phase 3 rescue regimen;high dose methotrxate
3 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
4 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2 TRC105;Bevacizumab
5 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
6 The French National Reference Centre of GTD Recruiting NCT02892877

Search NIH Clinical Center for Placental Site Trophoblastic Tumor

Cochrane evidence based reviews: trophoblastic tumor, placental site

Genetic Tests for Placental Site Trophoblastic Tumor

Anatomical Context for Placental Site Trophoblastic Tumor

MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

38
Placenta, Uterus, Lung, Ovary, Testis, Cervix, Brain

Publications for Placental Site Trophoblastic Tumor

Articles related to Placental Site Trophoblastic Tumor:

(show top 50) (show all 170)
# Title Authors Year
1
Fertility Sparing Strategies in Patients Affected by Placental Site Trophoblastic Tumor. ( 28840513 )
2017
2
Placental Site Trophoblastic Tumor in Nonseminomatous Mixed Germ Cell Tumors of the Testis: a Case Report and Review of the Literature. ( 29395947 )
2017
3
Placental site trophoblastic tumor with sole metastasis to breast: A case report. ( 28795129 )
2017
4
Presentation of Placental Site Trophoblastic Tumor with Amenorrhea. ( 28401076 )
2017
5
Diagnosis and management of a rare case with placental site trophoblastic tumor. ( 27751424 )
2016
6
Extrauterine Placental Site Trophoblastic Tumor Involving the Vagina. ( 27513078 )
2016
7
Imaging and Clinical Data of Placental Site Trophoblastic Tumor: A Case Report. ( 27679689 )
2016
8
Placental site trophoblastic tumor: A review of 108 cases and their implications for prognosis and treatment. ( 27168005 )
2016
9
SALL4 expression in gestational trophoblastic tumors: a useful tool to distinguish choriocarcinoma from placental site trophoblastic tumor and epithelioid trophoblastic tumor. ( 27068524 )
2016
10
Placental site trophoblastic tumor: a case report and review of the literature. ( 26622924 )
2015
11
Placental site trophoblastic tumor presented with vaginal metastasis. ( 25932270 )
2015
12
Placental site trophoblastic tumor: A case report and literature review. ( 26361566 )
2015
13
Placental-site trophoblastic tumor and fluorine-18- fluorodeoxyglucose positron emission tomography/ computed tomography. ( 26574698 )
2015
14
Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. ( 26261623 )
2015
15
Placental site trophoblastic tumor and choriocarcinoma: an unusual presentation. ( 26597227 )
2015
16
Retrospective analysis of the clinicopathologic and prognostic characteristics of stage I placental site trophoblastic tumor in China. ( 25572983 )
2015
17
Single synchronous pulmonary metastasis from placental site trophoblastic tumor and teratoma. ( 25908040 )
2015
18
Placental site trophoblastic tumor: report of a tertiary center experience. ( 26775357 )
2015
19
Attempted conservative management of a placental site trophoblastic tumor: a case report. ( 25314886 )
2014
20
Placental site trophoblastic tumor: a case report and review of the literature. ( 25593955 )
2014
21
Placental site trophoblastic tumor: Immunohistochemistry algorithm key to diagnosis and review of literature. ( 24624322 )
2014
22
Lupus nephritis associated with placental site trophoblastic tumor: A case report and review of the literature. ( 24944882 )
2014
23
Placental site trophoblastic tumor on endometrial polyp: a case report. ( 24654471 )
2014
24
Exaggerated placental site/placental site trophoblastic tumor: an underestimated risk factor for emergency peripartum hysterectomy. ( 25551954 )
2014
25
Placental site trophoblastic tumor with metastasis - A case report. ( 24532939 )
2013
26
Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome. ( 23274560 )
2013
27
Sonographic characteristics of placental site trophoblastic tumor. ( 22807194 )
2013
28
Placental site trophoblastic tumor, report of a case with unusual presentation. ( 23478075 )
2013
29
Diagnosis and treatment of placental site trophoblastic tumor. ( 23826431 )
2013
30
Atypical recurrence of a placental site trophoblastic tumor four years after hysterectomy for benign condition: Case report and review of literature. ( 24371716 )
2013
31
Long-term outcome of placental site trophoblastic tumor in The Netherlands. ( 23763007 )
2013
32
Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report. ( 23688193 )
2013
33
Unsuccessful planned conservative resection of placental site trophoblastic tumor. ( 23344410 )
2013
34
Placental site trophoblastic tumor in the pelvic wall: a case report and review of the literature. ( 24152517 )
2013
35
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. ( 23040933 )
2012
36
Clinical features of 17 cases of placental site trophoblastic tumor. ( 21862010 )
2011
37
Kidney involvement in a patient affected by placental site trophoblastic tumor. ( 21257242 )
2011
38
Two cases of placental site trophoblastic tumor. ( 22030056 )
2011
39
Placental Site Trophoblastic Tumor with lung metastases as cause of death in a young patient: a case report. ( 22027660 )
2011
40
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. ( 20381116 )
2010
41
Placental site trophoblastic tumor presenting as a friable cervical mass. ( 21061804 )
2010
42
Expression of glypican 3 in placental site trophoblastic tumor. ( 20868507 )
2010
43
Exaggerated placental site mimicking placental site trophoblastic tumor: case report and literature review. ( 21061810 )
2010
44
Placental site trophoblastic tumor: lymphatic spread and possible target markers. ( 19910023 )
2010
45
Placental site trophoblastic tumor--a challenging, rare entity. ( 21199764 )
2010
46
Placental site trophoblastic tumor with unusual presentation in the uterine cervix. ( 19819607 )
2010
47
Diagnostic evaluation of metastatic placental site trophoblastic tumor. ( 19622963 )
2009
48
Placental site trophoblastic tumor diagnosed on transvaginal sonography. ( 19644948 )
2009
49
Placental site trophoblastic tumor (PSTT) with multiple metastases and extremely poor prognosis. ( 19856056 )
2009
50
Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. ( 19366068 )
2009

Variations for Placental Site Trophoblastic Tumor

Expression for Placental Site Trophoblastic Tumor

Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for Placental Site Trophoblastic Tumor

GO Terms for Placental Site Trophoblastic Tumor

Cellular components related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 CGB3 CGB5 CSH1 EGFR GPC3 INHA

Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.63 CGB3 CGB5 EGFR INHA LNPEP SALL4
2 lung development GO:0030324 9.4 EGFR GPC3
3 SMAD protein signal transduction GO:0060395 9.37 INHA LNPEP
4 peptide hormone processing GO:0016486 9.32 CGB3 CGB5
5 female gamete generation GO:0007292 9.26 CGB3 CGB5
6 regulation of receptor activity GO:0010469 9.26 CGB3 CGB5 CSH1 INHA
7 cell-cell signaling GO:0007267 8.92 CGB3 CGB5 INHA LNPEP

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CGB3 CSH1 INHA

Sources for Placental Site Trophoblastic Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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