MCID: PLC003
MIFTS: 48

Placental Site Trophoblastic Tumor malady

Categories: Rare diseases, Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Placental Site Trophoblastic Tumor

About this section
Sources:
11Disease Ontology, 13DISEASES, 52Orphanet, 46NIH Rare Diseases, 48Novoseek, 37MeSH, 66UMLS, 43NCIt, 67UMLS via Orphanet, 29ICD10 via Orphanet, 38MESH via Orphanet, 28ICD10, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Placental Site Trophoblastic Tumor:

Name: Placental Site Trophoblastic Tumor 11 13 52
Trophoblastic Tumor, Placental Site 37 66
Trophoblastic Tumor Placental Site 46 48
Placental-Site Gestational Trophoblastic Neoplasm 11
 
Placenta Neoplasm 46
Deciduoma 66
Psst 52

Characteristics:

Orphanet epidemiological data:

52
placental site trophoblastic tumor:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Disease Ontology11 DOID:3596
MeSH37 D018245
NCIt43 C3757
Orphanet52 ORPHA99928
SNOMED-CT60 237252008, 75320001
UMLS via Orphanet67 C0206666
ICD10 via Orphanet29 D39.2
MESH via Orphanet38 D018245
ICD1028 C58

Summaries for Placental Site Trophoblastic Tumor

About this section
Wikipedia:69 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards based summary: Placental Site Trophoblastic Tumor, also known as trophoblastic tumor, placental site, is related to choriocarcinoma and kidney pelvis sarcomatoid transitional cell carcinoma, and has symptoms including abnormality of the menstrual cycle, spontaneous abortion and uterine neoplasm. An important gene associated with Placental Site Trophoblastic Tumor is GPC3 (Glypican 3), and among its related pathways are Alzheimers Disease Pathway and Agrin Interactions at Neuromuscular Junction. Affiliated tissues include placenta, lung and uterus, and related mouse phenotypes are limbs/digits/tail and digestive/alimentary.

Related Diseases for Placental Site Trophoblastic Tumor

About this section

Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1choriocarcinoma29.6CSH1, NR0B1, PAM
2kidney pelvis sarcomatoid transitional cell carcinoma10.6EGFR, ERBB2
3ossifying fibromyxoid tumor10.5EGFR, ERBB2
4her2-receptor negative breast cancer10.5EGFR, ERBB2
5glottis verrucous carcinoma10.5EGFR, ERBB2
6bladder colonic type adenocarcinoma10.5EGFR, ERBB2
7animal phobia10.5EGFR, ERBB2
8gastric squamous cell carcinoma10.5EGFR, ERBB2
9breast papillary carcinoma10.5EGFR, ERBB2
10anomalous left coronary artery from the pulmonary artery10.5EGFR, ERBB2
11apocrine adenocarcinoma10.5EGFR, ERBB2
12ovarian small cell carcinoma10.5EGFR, ERBB2
13central centrifugal cicatricial alopecia10.5EGFR, ERBB2
14adenosquamous carcinoma10.5EGFR, ERBB2
15pleomorphic carcinoma10.5EGFR, ERBB2
16adenomyosis10.5EGFR, ERBB2
17scrotal carcinoma10.5EGFR, ERBB2
18novak syndrome10.5EGFR, ERBB2
19ampulla of vater adenocarcinoma10.4EGFR, ERBB2
20ductal carcinoma in situ10.4EGFR, ERBB2
21early congenital syphilis10.4EGFR, ERBB2
22lethal restrictive dermopathy, lmna-related10.4EGFR, VEGFA
23postpoliomyelitis syndrome10.4EGFR, ERBB2
24fallopian tube mucinous adenocarcinoma10.4EGFR, ERBB2
25calcaneonavicular coalition10.4EGFR, VEGFA
26stampe sorensen syndrome10.4EGFR, VEGFA
27milker's nodule10.4EGFR, ERBB2
28paranasal sinus cancer, adult10.4ERBB2, INHA
29weaver johnson syndrome10.3ERBB2, VEGFA
30prostate adenoid cystic carcinoma10.3EGFR, VEGFA
31charcot-marie-tooth disease, type 1e10.3ERBB2, NR0B1
32tonsil cancer10.3EGFR, ERBB2
33mantle cell lymphoma10.3EGFR, VEGFA
34leiomyosarcoma10.3ERBB2, VEGFA
35integumentary system cancer10.3EGFR, VEGFA
36progesterone-receptor positive breast cancer10.3EGFR, ERBB2
37epithelioid trophoblastic tumor10.2
38oral lichen planus10.2EGFR, VEGFA
39placental site trophoblastic tumor10.2CSH1, INHA
40dysgraphia10.2EGFR, ERBB2
41verloove vanhorick brubakk syndrome10.2EGFR, VEGFA
42lung carcinoma in situ10.2ERBB2, VEGFA
43progeria10.2EGFR, GPC3
44teratoma10.2
45gestational trophoblastic neoplasm10.1
46trophoblastic neoplasm10.1
47leigh syndrome10.1
48ectopic pregnancy10.1
49leiomyoma10.1
50vaginitis10.1

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Symptoms for Placental Site Trophoblastic Tumor

About this section

Symptoms:

 52
  • amenorrhea
  • spontaneous abortion
  • low maternal serum chorionic gonadotropin
  • metrorrhagia

HPO human phenotypes related to Placental Site Trophoblastic Tumor:

(show all 7)
id Description Frequency HPO Source Accession
1 abnormality of the menstrual cycle hallmark (90%) HP:0000140
2 spontaneous abortion hallmark (90%) HP:0005268
3 uterine neoplasm hallmark (90%) HP:0010784
4 neoplasm of the liver occasional (7.5%) HP:0002896
5 neoplasm of the nervous system occasional (7.5%) HP:0004375
6 neoplasm of the lung occasional (7.5%) HP:0100526
7 vaginal neoplasm occasional (7.5%) HP:0100650

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

About this section

Drugs for Placental Site Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BevacizumabPhase 21938216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
2
NitroglycerinPhase 214655-63-04510
Synonyms:
1,2,3-Propanetrioltrinitrate
1,2,3-Propanetriyl nitrate
100292-13-5
105469-31-6
55-63-0
80066-48-4
8013-23-8
9010-02-0
AC1L1IBV
Adesitrin
Aldonitrin
Angibid
Angiolingual
Angiplex
Anglix
Angonist
Angorin
Anogesic
Aquo-Trimitrosan
BIDD:GT0142
BRN 1802063
Blasting gelatin
Blasting oil
Buccal
Buccard
C07455
C3H5N3O9
CCRIS 4089
CHEBI:28787
CHEMBL730
CID4510
CPD-143
Cardabid
Cardamist
Cardinit
Cardiodisco
Cellegesic
Chitamite
Colenitral
Cordipatch
Corditrine
Coro-Nitro
D00515
D005996
DB00727
Dauxona
Deponit
Deponit 5
Deponit TTS 10
Deponit TTS 5
Deponit-5
Diafusor
Discotrine
Dynamite
EINECS 200-240-8
Epinitril
GTN
GTN-Pohl
Gepan Nitroglicerin
Gilucor nitro
Gilustenon
Glonoin
Glycerin trinitrate
Glycerine trinitrate
Glycerintrinitrate
Glycerol trinitrate
Glycerol, nitric acid triester
Glyceroli trinitratis
Glyceroltrinitraat
Glyceroltrinitrat
Glyceryl
Glyceryl nitrate
Glyceryl trinitrate
Glycerylnitrat
Glytrin
HMS2094M15
HSDB 30
Herwicard
Herzer
IMX-150
Klavikordal
LS-7741
Lenitral
Lentonitrina
MED-2002
MQX-503
Mi-Trates
Millisrol
Minitram
Minitran
Minitran (TN)
Minitro
Mionitrat
Myocon
Myoglycerin
Myovin
NG
NITRO IV
NK-843
NTG
Natispray
Neos nitro OPT
Niglin
Niglycon
Niong
Niong Retard
Nirmin
Nit-Ret
Nitora
Nitradisc
Nitradisc Pad
Nitradisc TTS
Nitrangin
Nitrek
Nitriderm
Nitriderm TTS
Nitrine-TDC
Nitro Bid
Nitro Dur
Nitro Dur TTS
Nitro Mack Retard
Nitro Retard
Nitro Rorer
Nitro-Bid
Nitro-Dur 10
Nitro-Dur 5
Nitro-Gesanit Retard
Nitro-M-Bid
Nitro-Mack Retard
Nitro-Par
Nitro-Pflaster
Nitro-Span
Nitro-Time
Nitro-bid (TN)
Nitro-dur
Nitro-dur (TN)
Nitro-lent
NitroBid
NitroCor
 
NitroDur
NitroMist
NitroQuick
NitroQuik
Nitroard
Nitrobaat
Nitrobid Oint
Nitrobukal
Nitrocap
NitrocapT.D
NitrocapT.D.
Nitrocard
Nitrocerin
Nitrocine
Nitrocine 5
Nitroclyn
Nitrocontin
Nitrocontin Continus
Nitrocot
Nitroderm
Nitroderm TTS
Nitroderm TTS Ext
Nitroderm TTS-5
Nitrodisc
Nitrodyl
Nitrodyl TTS
Nitrogard
Nitrogard-SR
Nitroglicerina
Nitrogliceryna
Nitroglin
Nitroglycerin
Nitroglycerin (NG)
Nitroglycerin ointment
Nitroglycerin-ACC
Nitroglycerine
Nitroglycerol
Nitroglyn
Nitroject
Nitrol Ointment
Nitrolan
Nitroletten
Nitrolin
Nitrolingual
Nitrolingual Spray
Nitrolowe
Nitromack Retard
Nitromed
Nitromel
Nitromex
Nitromint
Nitromint Aerosol
Nitromint Retard
Nitromist
Nitromist (TN)
Nitronal Aqueous
Nitronet
Nitrong
Nitrong Retard
Nitrong parenteral
Nitrong-SR
Nitropatch
Nitropen
Nitropercuten
Nitroperlinit
Nitroplast
Nitroprol
Nitropront
Nitroprontan
Nitrorectal
Nitroretard
Nitrorex
Nitrospan
Nitrostabilin
Nitrostat
Nitrovis
Nitrozell retard
Nysconitrine
Percutol
Percutol Oint
Percutol Oint.
Perganit
Perglottal
Perlinganit
Plastranit
Polnitrin
Propane-1,2,3-triyl trinitrate
RCRA waste no. P081
Ratiopharm
Rectogesic
SDM No. 17
SK-106N
SK-866
SK-878
Soup
Spirit of glonoin
Susadrin
Suscard
Sustac
Sustak
Sustonit
TNG
Temponitrin
Top-Nitro
Transderm Nitro
Transderm nitro
Transderm-N TTS
Transderm-Nitro TTS
Transderm-nitro
Transderm-nitro (TN)
Transiderm-nitro
Tridil
Tridil sublin
Trinalgon
Trinipatch
Triniplas
Trinitrate, Glyceryl
Trinitrin
Trinitrin Tablets
Trinitrina Erba
Trinitrine
Trinitroglycerin
Trinitroglycerol
Trinitrol
Trinitrolong
Trinitron
Trinitrosan
Turicard
UN0143
UN0144
UN1204
UN3064
UN3319
UNII-G59M7S0WS3
Vascana
Vasoglyn
Vasolator
Vernies
Willong
c0061
nitroglycerin
3
nivolumab254946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab

Interventional clinical trials:

idNameStatusNCT IDPhase
1Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for ChoriocarcinomaNot yet recruitingNCT00294177Phase 4
2Second Curettage in Treating Patients With Persistent Non-Metastatic Gestational Trophoblastic TumorRecruitingNCT00521118Phase 2
3Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)Not yet recruitingNCT02664961Phase 2
4The French National Reference Centre of GTDRecruitingNCT02892877
5Nivolumab and Ipilimumab in Treating Patients With Rare TumorsNot yet recruitingNCT02834013

Search NIH Clinical Center for Placental Site Trophoblastic Tumor


Cochrane evidence based reviews: trophoblastic tumor, placental site

Genetic Tests for Placental Site Trophoblastic Tumor

About this section

Anatomical Context for Placental Site Trophoblastic Tumor

About this section

MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

34
Placenta, Lung, Uterus, Liver, Ovary, Testis, Brain

Animal Models for Placental Site Trophoblastic Tumor or affiliated genes

About this section

MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6EGFR, ERBB2, GPC3, VEGFA
2MP:00053818.2EGFR, ERBB2, GPC3, INHA, VEGFA
3MP:00020068.2EGFR, ERBB2, INHA, NR0B1, VEGFA
4MP:00053888.1EGFR, ERBB2, GPC3, PAM, VEGFA
5MP:00053808.0EGFR, ERBB2, GPC3, PAM, VEGFA
6MP:00053897.9EGFR, ERBB2, GPC3, INHA, NR0B1, VEGFA
7MP:00053857.2EGFR, ERBB2, GPC3, INHA, PAM, VEGFA
8MP:00053766.5EGFR, ERBB2, GPC3, INHA, NR0B1, PAM

Publications for Placental Site Trophoblastic Tumor

About this section

Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 164)
idTitleAuthorsYear
1
Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. (26261623)
2015
2
Placental site trophoblastic tumor presented with vaginal metastasis. (25932270)
2015
3
Single synchronous pulmonary metastasis from placental site trophoblastic tumor and teratoma. (25908040)
2015
4
Placental site trophoblastic tumor: a case report and review of the literature. (26622924)
2015
5
Placental site trophoblastic tumor on endometrial polyp: a case report. (24654471)
2014
6
Placental site trophoblastic tumor: a case report and review of the literature. (25593955)
2014
7
Unsuccessful planned conservative resection of placental site trophoblastic tumor. (23344410)
2013
8
Placental site trophoblastic tumor, report of a case with unusual presentation. (23478075)
2013
9
Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report. (23688193)
2013
10
Clinical features of 17 cases of placental site trophoblastic tumor. (21862010)
2011
11
Placental site trophoblastic tumor--a challenging, rare entity. (21199764)
2010
12
Placental site trophoblastic tumor presenting as a friable cervical mass. (21061804)
2010
13
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. (20381116)
2010
14
Expression of glypican 3 in placental site trophoblastic tumor. (20868507)
2010
15
Placental site trophoblastic tumor. (19935163)
2009
16
Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. (19366068)
2009
17
Survival of placental-site trophoblastic tumor patients strongly linked with time since related pregnancy. (19670504)
2009
18
Absence of Y chromosome in human placental site trophoblastic tumor. (17643092)
2007
19
Placental site trophoblastic tumor: report of four cases and review of literature. (17291263)
2007
20
Fertility sparing therapy in a patient with placental site trophoblastic tumor: a case report. (17007914)
2006
21
Placental site trophoblastic tumor: a case report. (16550983)
2006
22
Placental site trophoblastic tumor originating in a tubal ectopic pregnancy. (16423444)
2006
23
Chemoresistant placental site trophoblastic tumor with hilar lymph node metastasis: an unusual site of involvement. (15661251)
2005
24
Placental site trophoblastic tumor in a postmenopausal female--a case report. (15099979)
2004
25
Placental site trophoblastic tumor: an overview. (15457847)
2004
26
Ultrasound diagnosis of uterine arteriovenous fistula associated with placental site trophoblastic tumor. (12808680)
2003
27
Adrenal metastatic placental site trophoblastic tumor. Case report. (12744102)
2003
28
Placental site trophoblastic tumor (PSTT) in mother and child: first report of PSTT in infancy. (11836719)
2002
29
Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center. (11520134)
2001
30
Spontaneous uterine perforation mimicking ectopic pregnancy as the initial presentation of placental site trophoblastic tumor. (11768287)
2001
31
Placental site trophoblastic tumor metastasizing to the brain. Case illustration. (11147884)
2001
32
Placental site trophoblastic tumor. Clinical and pathological report of two cases. (11173663)
2000
33
Failure of high-dose chemotherapy with peripheral blood stem cell support for refractory placental site trophoblastic tumor. (10087421)
1999
34
Successful treatment of malignant placental site trophoblastic tumor with combined cytostatic-surgical approach: case report and review of literature. (10502447)
1999
35
Prognostic factors and treatment for placental site trophoblastic tumor-report of 3 cases and analysis of 88 cases. (10329037)
1999
36
MR appearance of placental site trophoblastic tumor: a report of three cases. (9456970)
1998
37
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
38
Cytodiagnosis of placental site trophoblastic tumor. A report of two cases. (9622699)
1998
39
Placental site trophoblastic tumor (PSTT) initially misdiagnosed as cervical carcinoma. (9198108)
1997
40
Trophoblastic tumors of the testis other than classic choriocarcinoma: &quot;monophasic&quot; choriocarcinoma and placental site trophoblastic tumor: a report of two cases. (9060597)
1997
41
Placental site trophoblastic tumor: molecular analysis and clinical experience. (9816247)
1996
42
Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. (7691711)
1993
43
Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor. (11576278)
1992
44
Erythrocytosis associated with a placental-site trophoblastic tumor. (1314361)
1992
45
Malignant placental site trophoblastic tumor associated with placental abruption, fetal distress, and elevated CA-125. (1334939)
1992
46
Invasive mole and placental site trophoblastic tumor. Two entities of gestational trophoblastic disease with a common ultrasonographic appearance. (1656062)
1991
47
Placental site trophoblastic tumor: with features between an exaggerated placental site reaction and a placental site trophoblastic tumor. (2332271)
1990
48
Malignant placental site trophoblastic tumor. (2991836)
1985
49
Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. (6329973)
1984
50
Placental site trophoblastic tumor of the uterus: an ultrastructural and immunohistochemical study. (6091306)
1984

Variations for Placental Site Trophoblastic Tumor

About this section

Expression for genes affiliated with Placental Site Trophoblastic Tumor

About this section
Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

About this section

GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

About this section

Cellular components related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.8EGFR, GPC3, INHA, PAM, VEGFA

Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1ERBB2 signaling pathwayGO:003812810.1EGFR, ERBB2
2cellular response to epidermal growth factor stimulusGO:007136410.0EGFR, ERBB2
3regulation of cell motilityGO:200014510.0EGFR, ERBB2
4positive regulation of cell adhesionGO:00457859.8ERBB2, VEGFA
5ovarian follicle developmentGO:00015419.7INHA, VEGFA
6lung developmentGO:00303249.4EGFR, GPC3, VEGFA
7positive regulation of protein phosphorylationGO:00019349.4EGFR, ERBB2, VEGFA
8lactationGO:00075959.4PAM, VEGFA
9positive regulation of MAP kinase activityGO:00434069.3EGFR, ERBB2, VEGFA
10positive regulation of epithelial cell proliferationGO:00506799.2EGFR, ERBB2, VEGFA
11cell surface receptor signaling pathwayGO:00071669.2EGFR, ERBB2, INHA
12nervous system developmentGO:00073998.9ERBB2, INHA, VEGFA

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:000471610.1EGFR, ERBB2
2transmembrane receptor protein tyrosine kinase activityGO:00047149.8EGFR, ERBB2
3protein heterodimerization activityGO:00469828.5EGFR, ERBB2, INHA, VEGFA

Sources for Placental Site Trophoblastic Tumor

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet