PSST
MCID: PLC003
MIFTS: 56

Placental Site Trophoblastic Tumor (PSST) malady

Cancer diseases, Reproductive diseases categories

Summaries for Placental Site Trophoblastic Tumor

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63Wikipedia, 32MalaCards
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Wikipedia:63 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards: Placental Site Trophoblastic Tumor, also known as trophoblastic tumor placental site, is related to choriocarcinoma and epithelioid trophoblastic tumor, and has symptoms including neoplasms/tumors, uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer and antenatal period/pregnancy anomalies. An important gene associated with Placental Site Trophoblastic Tumor is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Glycoprotein hormones and G-protein signaling K-RAS regulation pathway. The compounds griseofulvin and Afatinib have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and lung, and related mouse phenotype embryogenesis.

Aliases & Classifications for Placental Site Trophoblastic Tumor

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

48
placental site trophoblastic tumor:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


Aliases & Descriptions:

placental site trophoblastic tumor 8 10 48
trophoblastic tumor placental site 42 44
placental-site gestational trophoblastic neoplasm 8
trophoblastic tumor, placental site 60
neoplasm of placenta 60
placenta neoplasm 42
psst 48


External Ids:

Disease Ontology8 DOID:3596
MeSH34 D018245
NCIt39 C3757
MESH via Orphanet35 D018245
SNOMED-CT56 237252008, 75320001
ICD10 via Orphanet26 D39.2
SNOMED-CT via Orphanet57 237252008, 75320001
UMLS via Orphanet61 C0206666
ICD1025 C58

Related Diseases for Placental Site Trophoblastic Tumor

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1choriocarcinoma30.9ALPP, KRT18, GPC3, CGB, CGB5, CGA
2epithelioid trophoblastic tumor30.8MCAM
3gestational trophoblastic neoplasm30.6CGA, CGB5, CGB, ALPP
4trophoblastic neoplasm30.4CGA, CGB5
5placental choriocarcinoma10.6
6cervicitis10.4
7leiomyoma10.4
8arteriovenous fistula10.3
9placenta accreta10.3
10placental abruption10.3
11infertility10.3
12alopecia10.3
13alopecia areata10.3
14choriocarcinoma of the testis10.3
15pneumothorax10.3
16proteinuria10.3
17vaginitis10.3
18gestational choriocarcinoma10.1
19extragonadal germ cell tumor10.0CGB5
20thyroiditis10.0CGA
21pituitary adenoma10.0CGA
22endometriosis10.0CGA
23hypothyroidism10.0CGA
24viral hepatitis10.0KRT18
25hepatitis c10.0KRT18
26sertoli cell tumor10.0ALPP
27anencephaly10.0CGA
28arthritis10.0ALPP
29pancreatitis10.0ALPP
30hydrops fetalis10.0GPC3
31alpha thalassemia10.0EPO
32gingivitis10.0ALPP
33wilms tumor10.0GPC3
34sarcoma10.0CGB, CGB5
35gynecomastia10.0CGA, CGB5
36leydig cell tumor10.0CGA, CGB5
37hypogonadism10.0CGA, CGB5
38rheumatoid arthritis10.0KRT18
39ovarian hyperstimulation syndrome10.0CGB5, CGA
40klinefelter's syndrome10.0CGB, CGA
41prolactinoma10.0CGB, CGA
42ovarian cyst10.0CGA, CGB5
43gonadoblastoma10.0ALPP
44cryptococcosis10.0CGB, CGB5
45esophageal cancer10.0EGFR
46thymus cancer10.0ALPP, KRT18
47oligospermia10.0CGB5, CGA
48hepatitis b10.0ALPP, CGB
49osteosarcoma10.0CGB, ALPP
50kidney cancer10.0EGFR

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Clinical Features for Placental Site Trophoblastic Tumor

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Sources:
48Orphanet
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Symptoms:

48 (show all 9)
  • neoplasms/tumors
  • uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer
  • antenatal period/pregnancy anomalies
  • spontaneous abortions
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Placental Site Trophoblastic Tumor

Drug clinical trials:

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Search CenterWatch for Placental Site Trophoblastic Tumor

Genetic Tests for Placental Site Trophoblastic Tumor

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Anatomical Context for Placental Site Trophoblastic Tumor

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32MalaCards
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MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

32
Placenta, Uterus, Lung, Cervix, Liver, Ovary, Testis, Brain, Adrenal gland, Lymph node, Testes, Kidney

Animal Models for Placental Site Trophoblastic Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053807.9ALPP, ERBB2, KRT18, GPC3, EPO, EGFR

Publications for Placental Site Trophoblastic Tumor

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50PubMed
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Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 146)
idTitleAuthorsYear
1
Placental site trophoblastic tumor, report of a case with unusual presentation. (23478075)
2013
2
Atypical recurrence of a placental site trophoblastic tumor four years after hysterectomy for benign condition: Case report and review of literature. (24371716)
2013
3
Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome. (23274560)
2013
4
Placental Site Trophoblastic Tumor with lung metastases as cause of death in a young patient: a case report. (22027660)
2011
5
Placental site trophoblastic tumor presenting as a friable cervical mass. (21061804)
2010
6
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. (20381116)
2010
7
Placental site trophoblastic tumor: lymphatic spread and possible target markers. (19910023)
2010
8
Expression of glypican 3 in placental site trophoblastic tumor. (20868507)
2010
9
Placental site trophoblastic tumor with unusual presentation in the uterine cervix. (19819607)
2010
10
Exaggerated placental site mimicking placental site trophoblastic tumor: case report and literature review. (21061810)
2010
11
Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. (19366068)
2009
12
Survival of placental-site trophoblastic tumor patients strongly linked with time since related pregnancy. (19670504)
2009
13
Placental site trophoblastic tumor with multiple metastases and complete response to salvage BEP regimen: a case report and review of the literature. (18506643)
2009
14
Diagnostic evaluation of metastatic placental site trophoblastic tumor. (19622963)
2009
15
Placental site trophoblastic tumor in the ovary of a young child with isosexual precocious puberty. (18671454)
2009
16
Placental site trophoblastic tumor. (17701427)
2008
17
Non-gestational malignant placental site trophoblastic tumor of the ovary in a 4-year-old rhesus monkey. (18487497)
2008
18
Placental site trophoblastic tumor: a case report. (16550983)
2006
19
Placental site trophoblastic tumor (PSTT) with metastases to lungs and adrenal glands. (16499815)
2006
20
Clinical and pathologic characteristics and prognosis of placental site trophoblastic tumor. (17253041)
2006
21
Exclusion of lung metastases in placental site trophoblastic tumor using [18F]fluorodeoxyglucose positron emission tomography: a case report. (16051337)
2005
22
Placental site trophoblastic tumor: an overview. (15457847)
2004
23
Pathologic quiz case: a 26-year-old woman with profuse vaginal bleeding. Metastatic placental site trophoblastic tumor. (14987132)
2004
24
Placental site trophoblastic tumor: a review of 7 cases and their implications for prognosis and treatment. (15283052)
2004
25
Adrenal metastatic placental site trophoblastic tumor. Case report. (12744102)
2003
26
Placental site trophoblastic tumor: p53 gene analysis. (12691312)
2003
27
Successful management of metastatic placental site trophoblastic tumor with multiple pulmonary resections. (12468357)
2002
28
Placental site trophoblastic tumor (PSTT) in mother and child: first report of PSTT in infancy. (11836719)
2002
29
Advances in the understanding of placental site trophoblastic tumor. (12063871)
2002
30
Placental site trophoblastic tumor presenting with a pneumothorax during pregnancy. (12423837)
2002
31
Placental site trophoblastic tumor--past as prologue. (11520133)
2001
32
Prolonged remission of recurrent, metastatic placental site trophoblastic tumor after chemotherapy. (10620452)
2000
33
Placental site trophoblastic tumor. Clinical and pathological report of two cases. (11173663)
2000
34
Case 2. Placental site trophoblastic tumor. (10954498)
2000
35
Failure of high-dose chemotherapy with peripheral blood stem cell support for refractory placental site trophoblastic tumor. (10087421)
1999
36
Prognostic factors and treatment for placental site trophoblastic tumor-report of 3 cases and analysis of 88 cases. (10329037)
1999
37
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
38
Metastatic placental site trophoblastic tumor: long-term remission in a patient treated with EMA/CO chemotherapy. (9454662)
1998
39
Placental site trophoblastic tumor (PSTT) initially misdiagnosed as cervical carcinoma. (9198108)
1997
40
Metastasizing placental site trophoblastic tumor: immunohistochemical and DNA analysis. 2 case reports and a review of the literature. (9059751)
1997
41
Placental site trophoblastic tumor: molecular analysis and clinical experience. (9816247)
1996
42
Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor. (11576278)
1992
43
Erythrocytosis associated with a placental-site trophoblastic tumor. (1314361)
1992
44
Invasive mole and placental site trophoblastic tumor. Two entities of gestational trophoblastic disease with a common ultrasonographic appearance. (1656062)
1991
45
Sonographic appearance of placental site trophoblastic tumor. (2170669)
1990
46
Placental site trophoblastic tumor: with features between an exaggerated placental site reaction and a placental site trophoblastic tumor. (2332271)
1990
47
Placental site trophoblastic tumor: immunohistochemical and nuclear DNA study. (2167284)
1990
48
Placental-site trophoblastic tumor of the uterus. Clinicopathological and immunohistochemical observations of a case. (2833063)
1987
49
Placental-site trophoblastic tumor: diagnosis, treatment, and biological behavior. (2852176)
1985
50
Placental-site trophoblastic tumor: current status. (6200262)
1984

Genetic Variations for Placental Site Trophoblastic Tumor

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Expression for genes affiliated with Placental Site Trophoblastic Tumor

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Placental Site Trophoblastic Tumor

Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8CGB, CGA
29.6EGFR, EPO
39.6ERBB2, EGFR
4
Hide members
9.6ERBB2, EGFR
59.2ERBB2, EPO, EGFR
69.1ERBB2, GPC3, EGFR

Compounds for genes affiliated with Placental Site Trophoblastic Tumor

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1griseofulvin44 1111.0KRT18, CGA
2Afatinib119.9EGFR, ERBB2
3pd158780449.9EGFR, ERBB2
4iressa599.9ERBB2, EGFR
5ag 1478 hydrochloride599.9ERBB2, EGFR
6ag 490599.9ERBB2, EGFR
711-ketotestosterone449.9CGB5, CGA
8jnj 28871063 hydrochloride599.9EGFR, ERBB2
9pertuzumab44 49 1111.8EGFR, ERBB2
10pki-166449.7ERBB2, EGFR
11cycloheximide449.7CGB5, ALPP
12fulvestrant44 49 28 1112.7KRT18, EGFR, ERBB2
13anastrozole44 1110.7ERBB2, EGFR, CGA
14oestriol449.6CGB, CGA, CGB5
15letrozole44 49 59 1112.6ERBB2, CGA, EGFR
16hrgbeta1449.6ERBB2, EGFR
17quinazoline449.6ERBB2, EGFR
18vinorelbine44 1110.6ERBB2, EGFR, EPO
19ctp449.6CGB, CGB5, CGA
20clomiphene citrate449.6CGB5, CGB, CGA
21topotecan44 1110.6EPO, ERBB2, EGFR
22ifosfamide44 1110.6CGA, CGB, CGB5
23cetrorelix44 28 1111.5EGFR, CGA, CGB5
24celecoxib44 59 28 49 11 2414.4EGFR, ERBB2, EPO
25organon449.4CGA, CGB5
26tetracycline44 1110.4EGFR, ERBB2, KRT18
27androstenedione44 2410.4CGA, CGB5, CGB
28carboplatin44 49 1111.3CGA, EGFR, EPO, ERBB2
29bleomycin44 1110.2CGB, CGA, EPO, CGB5
30leucovorin44 49 1111.1CGB5, EGFR, ERBB2, CGB
31etoposide44 49 59 1112.1CGB, ERBB2, CGB5, CGA
32vitamin d449.1ALPP, ERBB2, CGA, EPO
33dmso449.0ALPP, KRT18, CGB5, CGA
34cyclophosphamide44 49 1110.9CGB5, ERBB2, KRT18, CGB, CGA
35aspartate448.9EPO, CGA, KRT18, ERBB2, ALPP
36methotrexate44 49 1110.8ERBB2, CGA, CGB, CGB5, EPO
37gnrh448.8CGA, CGB5, CGB, EPO, ERBB2
38doxorubicin44 49 1110.7EGFR, ERBB2, CGA, KRT18, CGB5
39ascorbic acid44 249.7ALPP, CGB5, CGA, EPO, KRT18
40folate448.6ALPP, CGA, ERBB2, CGB5, EPO
41progestin448.6EGFR, CGA, CGB5, ERBB2, ALPP
42tamoxifen44 49 28 1111.5ERBB2, ALPP, CGB5, CGA, EGFR
43progesterone44 59 28 11 2412.4CGA, EGFR, CGB5, CGB, KRT18, ERBB2
44creatinine448.4EPO, KRT18, ALPP, CGA, CGB5, CGB
45alanine448.3CGA, ERBB2, KRT18, CGB, ALPP
46paraffin448.2CGB5, CGA, EGFR, KRT18, ERBB2, ALPP
47lactate448.0CGA, CGB5, CGB, EPO, KRT18, ERBB2
48cisplatin44 49 59 1110.9CGB5, CGA, EGFR, CGB, EPO, ERBB2
49testosterone44 59 11 2410.6EPO, KRT18, ERBB2, ALPP, CGB, CGB5
50vegf447.6EGFR, CGA, CGB5, CGB, EPO, KRT18

GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

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16Gene Ontology
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Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.8CGB, CGA
2anatomical structure morphogenesisGO:0096538.7KRT18, GPC3, MCAM
3signal transductionGO:0071658.3EGFR, CGA, CGB, EPO, ERBB2

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.6ERBB2, EGFR
2transmembrane receptor protein tyrosine kinase activityGO:0047149.6ERBB2, EGFR
3hormone activityGO:0051799.4EPO, CGB, CGA
4receptor signaling protein tyrosine kinase activityGO:0047169.3ERBB2, EGFR

Products for genes affiliated with Placental Site Trophoblastic Tumor

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  • Antibodies
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Sources for Placental Site Trophoblastic Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet