MCID: PLC003
MIFTS: 45

Placental Site Trophoblastic Tumor malady

Rare diseases, Cancer diseases, Reproductive diseases categories

Aliases & Classifications for Placental Site Trophoblastic Tumor

About this section
Sources:
10Disease Ontology, 51Orphanet, 45NIH Rare Diseases, 47Novoseek, 65UMLS, 36MeSH, 59SNOMED-CT, 42NCIt, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Placental Site Trophoblastic Tumor:

Name: Placental Site Trophoblastic Tumor 10 51
Trophoblastic Tumor, Placental Site 65 36
Trophoblastic Tumor Placental Site 45 47
Placental-Site Gestational Trophoblastic Neoplasm 10
 
Placenta Neoplasm 45
Deciduoma 65
Psst 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
placental site trophoblastic tumor:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Adult


External Ids:

Disease Ontology10 DOID:3596
NCIt42 C3757
MeSH36 D018245
Orphanet51 99928
SNOMED-CT59 75320001, 237252008
ICD10 via Orphanet28 D39.2
MESH via Orphanet37 D018245
UMLS via Orphanet66 C0206666
ICD1027 C58

Summaries for Placental Site Trophoblastic Tumor

About this section
Wikipedia:68 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards based summary: Placental Site Trophoblastic Tumor, also known as trophoblastic tumor, placental site, is related to choriocarcinoma and epithelioid trophoblastic tumor, and has symptoms including abnormality of the menstrual cycle, spontaneous abortion and uterine neoplasm. An important gene associated with Placental Site Trophoblastic Tumor is INHA (Inhibin, Alpha), and among its related pathways are Signaling events mediated by TCPTP and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include placenta, lung and uterus, and related mouse phenotypes are limbs/digits/tail and skeleton.

Related Diseases for Placental Site Trophoblastic Tumor

About this section

Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1choriocarcinoma10.7
2epithelioid trophoblastic tumor10.6
3teratoma10.6
4ectopic pregnancy10.5
5cervicitis10.5
6vaginitis10.5
7gestational trophoblastic neoplasm10.5
8trophoblastic neoplasm10.5
9testicular germ cell tumor10.3
10alopecia10.3
11arteriovenous fistula10.3
12placental abruption10.3
13placenta accreta10.3
14infertility10.3
15alopecia areata10.3
16leiomyoma10.3
17pneumothorax10.3
18nonseminomatous germ cell tumor10.3
19precocious puberty10.3
20invasive mole10.3
21leigh syndrome10.3
22supernumerary nipples10.3CGB, EGFR
23breast metaplastic carcinoma10.2EGFR, ERBB2
24extrasystoles short stature hyperpigmentation microcephaly10.2CGB, CGB5
25enophthalmos10.2EGFR, ERBB2
26estrogen-receptor negative breast cancer10.2EGFR, ERBB2
27malignant cystic nephroma10.2EGFR, ERBB2
28vagina leiomyosarcoma10.2EGFR, ERBB2
29bilirubin metabolic disorder10.2EGFR, ERBB2
30microscopic colitis10.2EGFR, ERBB2
31esophageal adenoid cystic carcinoma10.2EGFR, ERBB2
32cystic basal cell carcinoma10.2EGFR, ERBB2
33bronchial disease10.2EGFR, ERBB2
34scrotum basal cell carcinoma10.2EGFR, ERBB2
35familial cold autoinflammatory syndrome 210.2CGB, CGB5
36nonsyndromic hereditary sensorineural hearing loss10.2CGB5, ERBB2
37nontoxic goiter10.2EGFR, ERBB2
38follicular dendritic cell sarcoma10.2EGFR, ERBB2
39familial renal papillary carcinoma10.2EGFR, ERBB2
40erdheim-chester disease10.2EGFR, ERBB2
41high molecular weight kininogen deficiency10.2EGFR, ERBB2
42placental site trophoblastic tumor10.2CGB, INHA
43gallbladder cancer10.2EGFR, ERBB2
44scrotum paget's disease10.2EGFR, ERBB2
45retinal dystrophies primarily involving bruch's membrane10.2CGB, INHA
46excessive tearing10.2EGFR, ERBB2
47precursor lymphoblastic lymphoma/leukemia10.1EGFR, ERBB2
48her2-receptor positive breast cancer10.1EGFR, ERBB2
49polyvesicular vitelline pattern ovarian yolk sac tumor10.1EGFR, ERBB2
50fallopian tube adenofibroma10.1ERBB2, INHA

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Symptoms for Placental Site Trophoblastic Tumor

About this section

Symptoms:

 51 (show all 9)
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • neoplasms/tumors
  • uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer
  • antenatal period/pregnancy anomalies
  • spontaneous abortions
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Placental Site Trophoblastic Tumor:

(show all 7)
id Description Frequency HPO Source Accession
1 abnormality of the menstrual cycle hallmark (90%) HP:0000140
2 spontaneous abortion hallmark (90%) HP:0005268
3 uterine neoplasm hallmark (90%) HP:0010784
4 neoplasm of the liver occasional (7.5%) HP:0002896
5 neoplasm of the nervous system occasional (7.5%) HP:0004375
6 neoplasm of the lung occasional (7.5%) HP:0100526
7 vaginal neoplasm occasional (7.5%) HP:0100650

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

About this section

Drugs for Placental Site Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Chorionic GonadotropinPhase 4164

Interventional clinical trials:

idNameStatusNCT IDPhase
1Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for ChoriocarcinomaNot yet recruitingNCT00294177Phase 4
2Second Curettage in Treating Patients With Persistent Non-Metastatic Gestational Trophoblastic TumorRecruitingNCT00521118Phase 2
3Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)Not yet recruitingNCT02664961Phase 2

Search NIH Clinical Center for Placental Site Trophoblastic Tumor


Cochrane evidence based reviews: Trophoblastic Tumor, Placental Site

Genetic Tests for Placental Site Trophoblastic Tumor

About this section

Anatomical Context for Placental Site Trophoblastic Tumor

About this section

MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

33
Placenta, Lung, Uterus, Liver, Cervix, Ovary, Testis

Animal Models for Placental Site Trophoblastic Tumor or affiliated genes

About this section

MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.2EGFR, ERBB2, GPC3, VEGFA
2MP:00053907.9EGFR, ERBB2, GPC3, INHA, VEGFA
3MP:00020067.9EGFR, ERBB2, INHA, VEGFA
4MP:00053817.8EGFR, ERBB2, GPC3, INHA, VEGFA
5MP:00053897.7EGFR, ERBB2, GPC3, INHA, VEGFA
6MP:00053857.2EGFR, ERBB2, GPC3, INHA, LNPEP, VEGFA

Publications for Placental Site Trophoblastic Tumor

About this section

Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. (26261623)
2015
2
Placental site trophoblastic tumor presented with vaginal metastasis. (25932270)
2015
3
Lupus nephritis associated with placental site trophoblastic tumor: A case report and review of the literature. (24944882)
2014
4
Unsuccessful planned conservative resection of placental site trophoblastic tumor. (23344410)
2013
5
Diagnosis and treatment of placental site trophoblastic tumor. (23826431)
2013
6
Placental site trophoblastic tumor, report of a case with unusual presentation. (23478075)
2013
7
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. (23040933)
2012
8
Clinical features of 17 cases of placental site trophoblastic tumor. (21862010)
2011
9
Kidney involvement in a patient affected by placental site trophoblastic tumor. (21257242)
2011
10
Two cases of placental site trophoblastic tumor. (22030056)
2011
11
Placental site trophoblastic tumor--a challenging, rare entity. (21199764)
2010
12
Placental site trophoblastic tumor presenting as a friable cervical mass. (21061804)
2010
13
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. (20381116)
2010
14
Placental site trophoblastic tumor: lymphatic spread and possible target markers. (19910023)
2010
15
Placental site trophoblastic tumor. (19935163)
2009
16
Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. (19366068)
2009
17
Survival of placental-site trophoblastic tumor patients strongly linked with time since related pregnancy. (19670504)
2009
18
Placental-site trophoblastic tumors: a case of resistant pulmonary metastasis. (18227827)
2008
19
Absence of Y chromosome in human placental site trophoblastic tumor. (17643092)
2007
20
Fertility sparing therapy in a patient with placental site trophoblastic tumor: a case report. (17007914)
2006
21
Exclusion of lung metastases in placental site trophoblastic tumor using [18F]fluorodeoxyglucose positron emission tomography: a case report. (16051337)
2005
22
Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature. (15958158)
2005
23
p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. (15316317)
2004
24
Placental site trophoblastic tumor in a postmenopausal female--a case report. (15099979)
2004
25
Placental site trophoblastic tumor: an overview. (15457847)
2004
26
Placental site trophoblastic tumor of the uterine cervix occurring from undetermined antecedent pregnancy. (15009614)
2004
27
Ultrasound diagnosis of uterine arteriovenous fistula associated with placental site trophoblastic tumor. (12808680)
2003
28
Adrenal metastatic placental site trophoblastic tumor. Case report. (12744102)
2003
29
Placental site trophoblastic tumor. (12832940)
2003
30
Successful management of metastatic placental site trophoblastic tumor with multiple pulmonary resections. (12468357)
2002
31
Placental site trophoblastic tumor (PSTT) in mother and child: first report of PSTT in infancy. (11836719)
2002
32
Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center. (11520134)
2001
33
Spontaneous uterine perforation mimicking ectopic pregnancy as the initial presentation of placental site trophoblastic tumor. (11768287)
2001
34
Prolonged remission of recurrent, metastatic placental site trophoblastic tumor after chemotherapy. (10620452)
2000
35
Placental site trophoblastic tumor. Clinical and pathological report of two cases. (11173663)
2000
36
Failure of high-dose chemotherapy with peripheral blood stem cell support for refractory placental site trophoblastic tumor. (10087421)
1999
37
MR appearance of placental site trophoblastic tumor: a report of three cases. (9456970)
1998
38
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
39
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
40
Metastatic placental site trophoblastic tumor: long-term remission in a patient treated with EMA/CO chemotherapy. (9454662)
1998
41
Unusual endovaginal ultrasonography and magnetic resonance imaging of placental site trophoblastic tumor. (8141195)
1994
42
Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. (7691711)
1993
43
Metastasizing placental site trophoblastic tumor. An immunohistochemical and flow cytometric study of two cases. (8396853)
1993
44
Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor. (11576278)
1992
45
Erythrocytosis associated with a placental-site trophoblastic tumor. (1314361)
1992
46
Placental site trophoblastic tumor associated with immature ovarian teratoma. (1972122)
1990
47
Clinical characteristics of placental site trophoblastic tumor (PSTT). (2842238)
1988
48
Malignant placental site trophoblastic tumor. (2991836)
1985
49
Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. (6329973)
1984
50
Placental site trophoblastic tumor of the uterus: an ultrastructural and immunohistochemical study. (6091306)
1984

Variations for Placental Site Trophoblastic Tumor

About this section

Expression for genes affiliated with Placental Site Trophoblastic Tumor

About this section
Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

About this section

GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

About this section

Cellular components related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.3CGB, CGB5, INHA, LNPEP, VEGFA

Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:001648610.1CGB, CGB5
2ovarian follicle developmentGO:00015419.9INHA, VEGFA
3female gamete generationGO:00072929.8CGB, CGB5
4positive regulation of cell adhesionGO:00457859.5ERBB2, VEGFA
5cell-cell signalingGO:00072679.2CGB, CGB5, INHA, LNPEP
6positive regulation of epithelial cell proliferationGO:00506799.1EGFR, ERBB2, VEGFA
7cell surface receptor signaling pathwayGO:00071669.1EGFR, ERBB2, INHA
8positive regulation of protein phosphorylationGO:00019348.9EGFR, ERBB2, VEGFA
9nervous system developmentGO:00073998.9ERBB2, INHA, VEGFA
10positive regulation of MAP kinase activityGO:00434068.8EGFR, ERBB2, VEGFA
11vascular endothelial growth factor receptor signaling pathwayGO:00480108.2EGFR, ERBB2, VEGFA
12signal transductionGO:00071657.4CGB, CGB5, EGFR, ERBB2, INHA, LNPEP

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:00047169.5EGFR, ERBB2
2hormone activityGO:00051799.5CGB, CGB5, INHA
3transmembrane receptor protein tyrosine kinase activityGO:00047149.1EGFR, ERBB2
4protein heterodimerization activityGO:00469828.2EGFR, ERBB2, INHA, VEGFA

Sources for Placental Site Trophoblastic Tumor

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet