PSST
MCID: PLC003
MIFTS: 49

Placental Site Trophoblastic Tumor (PSST) malady

Reproductive, Cancer categories

Summaries for Placental Site Trophoblastic Tumor

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards: Placental Site Trophoblastic Tumor, also known as trophoblastic tumor placental site, is related to epithelioid trophoblastic tumor and gestational trophoblastic tumor, and has symptoms including lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer, neoplasms/tumors and central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer. An important gene associated with Placental Site Trophoblastic Tumor is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Glycoprotein hormones and G-protein signaling K-RAS regulation pathway. The compounds griseofulvin and Afatinib have been mentioned in the context of this disorder. Affiliated tissues include ovary, brain and kidney, and related mouse phenotype embryogenesis.

Aliases & Classifications for Placental Site Trophoblastic Tumor

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 43NIH Rare Diseases, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Reproductive


Characteristics (Orphanet epidemiological data):

49
placental site trophoblastic tumor:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


Aliases & Descriptions:

placental site trophoblastic tumor 8 10 49
trophoblastic tumor placental site 43 45
placental-site gestational trophoblastic neoplasm 8
trophoblastic tumor, placental site 61
neoplasm of placenta 61
placenta neoplasm 43
psst 49


External Ids:

Disease Ontology8 DOID:3596
MeSH35 D018245
NCIt40 C3757
MESH via Orphanet36 D018245
SNOMED-CT57 237252008, 75320001
ICD10 via Orphanet26 D39.2
SNOMED-CT via Orphanet58 237252008, 75320001
UMLS via Orphanet62 C0206666

Related Diseases for Placental Site Trophoblastic Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid trophoblastic tumor30.8MCAM
2gestational trophoblastic tumor30.8CGA, CGB5, CGB
3ectopic pregnancy30.7CGB, CGB5, CGA
4teratoma30.7CGA, CGB5, CGB, GPC3, ALPP
5gestational trophoblastic neoplasm30.6CGA, CGB5, CGB, ALPP
6trophoblastic neoplasm30.4CGA, CGB5
7precocious puberty30.4CGA, CGB5
8placental choriocarcinoma10.7
9placenta accreta10.3
10placental abruption10.3
11infertility10.3
12alopecia10.3
13alopecia areata10.3
14nonseminomatous germ cell tumor10.3
15erythrocytosis10.3
16testicular germ cell tumor10.3
17invasive mole10.3
18n syndrome10.0
19extragonadal germ cell tumor10.0CGB5
20thyroiditis10.0CGA
21pituitary adenoma10.0CGA
22endometriosis10.0CGA
23hypothyroidism10.0CGA
24viral hepatitis10.0KRT18
25hepatitis c10.0KRT18
26sertoli cell tumor10.0ALPP
27anencephaly10.0CGA
28arthritis10.0ALPP
29pancreatitis10.0ALPP
30hydrops fetalis10.0GPC3
31thalassemia10.0EPO
32gingivitis10.0ALPP
33wilms tumor10.0GPC3
34sarcoma10.0CGB, CGB5
35gynecomastia10.0CGA, CGB5
36leydig cell tumor10.0CGA, CGB5
37hypogonadism10.0CGA, CGB5
38rheumatoid arthritis10.0KRT18
39ovarian hyperstimulation syndrome10.0CGB5, CGA
40klinefelter's syndrome10.0CGB, CGA
41prolactinoma10.0CGB, CGA
42ovarian cyst10.0CGA, CGB5
43gonadoblastoma10.0ALPP
44cryptococcosis10.0CGB, CGB5
45esophageal cancer10.0EGFR
46thymic carcinoma10.0ALPP, KRT18
47oligospermia10.0CGB5, CGA
48hepatitis b10.0ALPP, CGB
49osteosarcoma10.0CGB, ALPP
50kidney cancer10.0EGFR

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Clinical Features for Placental Site Trophoblastic Tumor

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 9)
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • neoplasms/tumors
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • antenatal period/pregnancy anomalies
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • spontaneous abortions

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Placental Site Trophoblastic Tumor

Drug clinical trials:

Search ClinicalTrials for Placental Site Trophoblastic Tumor

Search NIH Clinical Center for Placental Site Trophoblastic Tumor

Search CenterWatch for Placental Site Trophoblastic Tumor

Genetic Tests for Placental Site Trophoblastic Tumor

Anatomical Context for Placental Site Trophoblastic Tumor

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

33
Ovary, Brain, Kidney, Lymph node, Lung, Uterus, Adrenal gland, Placenta, Testis, Cervix, Fetal brain, Fetal lung, Testis germ

Animal Models for Placental Site Trophoblastic Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053807.9ALPP, ERBB2, KRT18, GPC3, EPO, EGFR

Publications for Placental Site Trophoblastic Tumor

Sources:
51PubMed
See all sources

Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 147)
idTitleAuthorsYear
1
Unsuccessful planned conservative resection of placental site trophoblastic tumor. (23344410)
2013
2
Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report. (23688193)
2013
3
Long-term outcome of placental site trophoblastic tumor in The Netherlands. (23763007)
2013
4
Sonographic characteristics of placental site trophoblastic tumor. (22807194)
2013
5
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. (23040933)
2012
6
Two cases of placental site trophoblastic tumor. (22030056)
2011
7
Placental site trophoblastic tumor diagnosed on transvaginal sonography. (19644948)
2009
8
Placental site trophoblastic tumor (PSTT) with multiple metastases and extremely poor prognosis. (19856056)
2009
9
Lack of genetic association between exaggerated placental site reaction and placental site trophoblastic tumor. (18753963)
2008
10
Human chorionic gonadotropin free beta-subunit measurement as a marker of placental site trophoblastic tumors. (18773632)
2008
11
Placental site trophoblastic tumor with antecedent molar pregnancy in association with human immunodeficiency virus infection. (17944923)
2008
12
Absence of Y chromosome in human placental site trophoblastic tumor. (17643092)
2007
13
Fertility sparing therapy in a patient with placental site trophoblastic tumor: a case report. (17007914)
2006
14
Placental site trophoblastic tumor: A study of 55 cases and review of the literature emphasizing factors of prognostic significance. (16246400)
2006
15
Placental site trophoblastic tumor--a challenging rare entity. (17290581)
2006
16
Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature. (15958158)
2005
17
Placental site trophoblastic tumor presenting as subaponeurotic metastasis. (15823131)
2005
18
Placental site trophoblastic tumor in a postmenopausal female--a case report. (15099979)
2004
19
Clinicopathological study of intermediate trophoblastic non-tumor lesions: exaggerated placental site and placental site nodule]. (15498215)
2004
20
Placental site trophoblastic tumor of the uterine cervix occurring from undetermined antecedent pregnancy. (15009614)
2004
21
Clinical-pathologic conference in general thoracic surgery: metastatic placental site trophoblastic tumor. (15001921)
2004
22
Placental site trophoblastic tumor arising from antecedent molar pregnancy. (14766272)
2004
23
Placental site trophoblastic tumor in a patient with brain and lung metastases. (15228435)
2004
24
Placental site trophoblastic tumor in a late recurrence of a nonseminomatous germ cell tumor of the testis. (15166678)
2004
25
Ultrasound diagnosis of uterine arteriovenous fistula associated with placental site trophoblastic tumor. (12808680)
2003
26
Placental site trophoblastic tumor. (12832940)
2003
27
Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center. (11520134)
2001
28
Placental site trophoblastic tumor metastasizing to the brain. Case illustration. (11147884)
2001
29
Metastatic placental site trophoblastic tumor: a case report. (11330731)
2001
30
Pregnancy with primary tubal placental site trophoblastic tumor--A case report and literature review. (10329055)
1999
31
Successful treatment of malignant placental site trophoblastic tumor with combined cytostatic-surgical approach: case report and review of literature. (10502447)
1999
32
Placental site trophoblastic tumor: imaging findings. (10646979)
1999
33
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
34
Placental site trophoblastic tumor: human placental lactogen and pregnancy-associated major basic protein as immunohistologic markers. (9496832)
1998
35
Metastatic placental site trophoblastic tumor. (9833615)
1998
36
Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. (9808132)
1998
37
Immunohistochemical analysis of cell cycle regulatory gene products in normal trophoblast and placental site trophoblastic tumor. (9656119)
1998
38
Trophoblastic tumors of the testis other than classic choriocarcinoma: &quot;monophasic&quot; choriocarcinoma and placental site trophoblastic tumor: a report of two cases. (9060597)
1997
39
P53 gene product and EGF-receptor are highly expressed in placental site trophoblastic tumor. (9385938)
1997
40
Placental-site trophoblastic tumor. Principles of diagnosis, clinical behaviour and treatment. (7556286)
1995
41
Placental site trophoblastic tumor. Report of three cases and review of the literature. (11578484)
1995
42
Transvaginal ultrasound of &quot;placental-site trophoblastic tumor&quot;]. (7727973)
1995
43
Unusual endovaginal ultrasonography and magnetic resonance imaging of placental site trophoblastic tumor. (8141195)
1994
44
Metastasizing placental site trophoblastic tumor. An immunohistochemical and flow cytometric study of two cases. (8396853)
1993
45
Placental site trophoblastic tumor: a report of radiologic, surgical, and pathologic methods of evaluating the extent of disease. (8394275)
1993
46
Placental site trophoblastic tumor. Diagnosis, clinical behavior and treatment. (1848895)
1991
47
Placental site trophoblastic tumor associated with immature ovarian teratoma. (1972122)
1990
48
Ovarian conservation in placental site trophoblastic tumor. (2160904)
1990
49
Malignant placental site trophoblastic tumor. (2991836)
1985
50
Placental site trophoblastic tumor of the uterus: an ultrastructural and immunohistochemical study. (6091306)
1984

Genetic Variations for Placental Site Trophoblastic Tumor

Expression for genes affiliated with Placental Site Trophoblastic Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Placental Site Trophoblastic Tumor

Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8CGB, CGA
29.6EGFR, EPO
39.6ERBB2, EGFR
4
Hide members
9.6ERBB2, EGFR
59.2ERBB2, EPO, EGFR
69.1ERBB2, GPC3, EGFR

Compounds for genes affiliated with Placental Site Trophoblastic Tumor

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 24HMDB
See all sources

Compounds related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1griseofulvin45 1111.0KRT18, CGA
2Afatinib119.9EGFR, ERBB2
3pd158780459.9EGFR, ERBB2
4iressa609.9ERBB2, EGFR
5ag 1478 hydrochloride609.9ERBB2, EGFR
6ag 490609.9ERBB2, EGFR
711-ketotestosterone459.9CGB5, CGA
8jnj 28871063 hydrochloride609.9EGFR, ERBB2
9pertuzumab45 50 1111.8EGFR, ERBB2
10pki-166459.7ERBB2, EGFR
11cycloheximide459.7CGB5, ALPP
12fulvestrant45 50 29 1112.7KRT18, EGFR, ERBB2
13anastrozole45 1110.7ERBB2, EGFR, CGA
14oestriol459.6CGB, CGA, CGB5
15letrozole45 50 60 1112.6ERBB2, CGA, EGFR
16hrgbeta1459.6ERBB2, EGFR
17quinazoline459.6ERBB2, EGFR
18vinorelbine45 1110.6ERBB2, EGFR, EPO
19ctp459.6CGB, CGB5, CGA
20clomiphene citrate459.6CGB5, CGB, CGA
21topotecan45 1110.6EPO, ERBB2, EGFR
22ifosfamide45 1110.6CGA, CGB, CGB5
23cetrorelix45 29 1111.5EGFR, CGA, CGB5
24celecoxib45 60 29 50 11 2414.4EGFR, ERBB2, EPO
25organon459.4CGA, CGB5
26tetracycline45 1110.4EGFR, ERBB2, KRT18
27androstenedione45 2410.4CGA, CGB5, CGB
28carboplatin45 50 1111.3CGA, EGFR, EPO, ERBB2
29bleomycin45 1110.2CGB, CGA, EPO, CGB5
30leucovorin45 50 1111.1CGB5, EGFR, ERBB2, CGB
31etoposide45 50 60 1112.1CGB, ERBB2, CGB5, CGA
32vitamin d459.1ALPP, ERBB2, CGA, EPO
33dmso459.0ALPP, KRT18, CGB5, CGA
34cyclophosphamide45 50 1110.9CGB5, ERBB2, KRT18, CGB, CGA
35aspartate458.9EPO, CGA, KRT18, ERBB2, ALPP
36methotrexate45 50 1110.8ERBB2, CGA, CGB, CGB5, EPO
37gnrh458.8CGA, CGB5, CGB, EPO, ERBB2
38doxorubicin45 50 1110.7EGFR, ERBB2, CGA, KRT18, CGB5
39ascorbic acid45 249.7ALPP, CGB5, CGA, EPO, KRT18
40folate458.6ALPP, CGA, ERBB2, CGB5, EPO
41progestin458.6EGFR, CGA, CGB5, ERBB2, ALPP
42tamoxifen45 50 29 1111.5ERBB2, ALPP, CGB5, CGA, EGFR
43progesterone45 60 29 11 2412.4CGA, EGFR, CGB5, CGB, KRT18, ERBB2
44creatinine458.4EPO, KRT18, ALPP, CGA, CGB5, CGB
45alanine458.3CGA, ERBB2, KRT18, CGB, ALPP
46paraffin458.2CGB5, CGA, EGFR, KRT18, ERBB2, ALPP
47lactate458.0CGA, CGB5, CGB, EPO, KRT18, ERBB2
48cisplatin45 50 60 1110.9CGB5, CGA, EGFR, CGB, EPO, ERBB2
49testosterone45 60 11 2410.6EPO, KRT18, ERBB2, ALPP, CGB, CGB5
50vegf457.6EGFR, CGA, CGB5, CGB, EPO, KRT18

GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

Sources:
16Gene Ontology
See all sources

Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.8CGB, CGA
2anatomical structure morphogenesisGO:0096538.7KRT18, GPC3, MCAM
3signal transductionGO:0071658.3EGFR, CGA, CGB, EPO, ERBB2

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.6ERBB2, EGFR
2transmembrane receptor protein tyrosine kinase activityGO:0047149.6ERBB2, EGFR
3hormone activityGO:0051799.4EPO, CGB, CGA
4receptor signaling protein tyrosine kinase activityGO:0047169.3ERBB2, EGFR

Products for genes affiliated with Placental Site Trophoblastic Tumor

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Placental Site Trophoblastic Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet