PSST
MCID: PLC003
MIFTS: 56

Placental Site Trophoblastic Tumor (PSST) malady

Cancer diseases, Reproductive diseases categories

Summaries for Placental Site Trophoblastic Tumor

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63Wikipedia, 32MalaCards
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Wikipedia:63 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards: Placental Site Trophoblastic Tumor, also known as trophoblastic tumor placental site, is related to choriocarcinoma and epithelioid trophoblastic tumor, and has symptoms including neoplasms/tumors, central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer and metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea. An important gene associated with Placental Site Trophoblastic Tumor is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Glycoprotein hormones and G-protein signaling K-RAS regulation pathway. The compounds griseofulvin and Afatinib have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and lung, and related mouse phenotype embryogenesis.

Aliases & Classifications for Placental Site Trophoblastic Tumor

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

48
placental site trophoblastic tumor:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


Aliases & Descriptions:

placental site trophoblastic tumor 8 10 48
trophoblastic tumor placental site 42 44
placental-site gestational trophoblastic neoplasm 8
trophoblastic tumor, placental site 60
neoplasm of placenta 60
placenta neoplasm 42
psst 48


External Ids:

Disease Ontology8 DOID:3596
MeSH34 D018245
NCIt39 C3757
MESH via Orphanet35 D018245
SNOMED-CT56 237252008, 75320001
ICD10 via Orphanet26 D39.2
SNOMED-CT via Orphanet57 237252008, 75320001
UMLS via Orphanet61 C0206666
ICD1025 C58

Related Diseases for Placental Site Trophoblastic Tumor

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1choriocarcinoma30.9ALPP, KRT18, GPC3, CGB, CGB5, CGA
2epithelioid trophoblastic tumor30.8MCAM
3gestational trophoblastic neoplasm30.6CGA, CGB5, CGB, ALPP
4trophoblastic neoplasm30.4CGA, CGB5
5placental choriocarcinoma10.6
6cervicitis10.4
7leiomyoma10.4
8arteriovenous fistula10.3
9placenta accreta10.3
10placental abruption10.3
11infertility10.3
12alopecia10.3
13alopecia areata10.3
14choriocarcinoma of the testis10.3
15pneumothorax10.3
16proteinuria10.3
17vaginitis10.3
18gestational choriocarcinoma10.1
19extragonadal germ cell tumor10.0CGB5
20thyroiditis10.0CGA
21pituitary adenoma10.0CGA
22endometriosis10.0CGA
23hypothyroidism10.0CGA
24viral hepatitis10.0KRT18
25hepatitis c10.0KRT18
26sertoli cell tumor10.0ALPP
27anencephaly10.0CGA
28arthritis10.0ALPP
29pancreatitis10.0ALPP
30hydrops fetalis10.0GPC3
31alpha thalassemia10.0EPO
32gingivitis10.0ALPP
33wilms tumor10.0GPC3
34sarcoma10.0CGB, CGB5
35gynecomastia10.0CGA, CGB5
36leydig cell tumor10.0CGA, CGB5
37hypogonadism10.0CGA, CGB5
38rheumatoid arthritis10.0KRT18
39ovarian hyperstimulation syndrome10.0CGB5, CGA
40klinefelter's syndrome10.0CGB, CGA
41prolactinoma10.0CGB, CGA
42ovarian cyst10.0CGA, CGB5
43gonadoblastoma10.0ALPP
44cryptococcosis10.0CGB, CGB5
45esophageal cancer10.0EGFR
46thymus cancer10.0ALPP, KRT18
47oligospermia10.0CGB5, CGA
48hepatitis b10.0ALPP, CGB
49osteosarcoma10.0CGB, ALPP
50kidney cancer10.0EGFR

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Clinical Features for Placental Site Trophoblastic Tumor

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Sources:
48Orphanet
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Symptoms:

48 (show all 9)
  • neoplasms/tumors
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • antenatal period/pregnancy anomalies
  • uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • spontaneous abortions
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Placental Site Trophoblastic Tumor

Drug clinical trials:

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Search NIH Clinical Center for Placental Site Trophoblastic Tumor

Search CenterWatch for Placental Site Trophoblastic Tumor

Genetic Tests for Placental Site Trophoblastic Tumor

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Anatomical Context for Placental Site Trophoblastic Tumor

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32MalaCards
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MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

32
Placenta, Uterus, Lung, Cervix, Liver, Ovary, Testis, Brain, Kidney, Adrenal gland, Testes, Lymph node

Animal Models for Placental Site Trophoblastic Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053807.9ALPP, ERBB2, KRT18, GPC3, EPO, EGFR

Publications for Placental Site Trophoblastic Tumor

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50PubMed
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Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 146)
idTitleAuthorsYear
1
Unsuccessful planned conservative resection of placental site trophoblastic tumor. (23344410)
2013
2
Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report. (23688193)
2013
3
Long-term outcome of placental site trophoblastic tumor in The Netherlands. (23763007)
2013
4
Sonographic characteristics of placental site trophoblastic tumor. (22807194)
2013
5
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. (23040933)
2012
6
Two cases of placental site trophoblastic tumor. (22030056)
2011
7
Placental site trophoblastic tumor diagnosed on transvaginal sonography. (19644948)
2009
8
Placental site trophoblastic tumor (PSTT) with multiple metastases and extremely poor prognosis. (19856056)
2009
9
Lack of genetic association between exaggerated placental site reaction and placental site trophoblastic tumor. (18753963)
2008
10
Human chorionic gonadotropin free beta-subunit measurement as a marker of placental site trophoblastic tumors. (18773632)
2008
11
Placental site trophoblastic tumor with antecedent molar pregnancy in association with human immunodeficiency virus infection. (17944923)
2008
12
Blood test for placental site trophoblastic tumor and nontrophoblastic malignancy for evaluating patients with low positive human chorionic gonadotropin results. (18720919)
2008
13
Absence of Y chromosome in human placental site trophoblastic tumor. (17643092)
2007
14
Fertility sparing therapy in a patient with placental site trophoblastic tumor: a case report. (17007914)
2006
15
Placental site trophoblastic tumor: A study of 55 cases and review of the literature emphasizing factors of prognostic significance. (16246400)
2006
16
Placental site trophoblastic tumor--a challenging rare entity. (17290581)
2006
17
Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature. (15958158)
2005
18
Placental site trophoblastic tumor presenting as subaponeurotic metastasis. (15823131)
2005
19
Placental site trophoblastic tumor: outcome of five cases including fertility preserving management. (15589580)
2005
20
Placental site trophoblastic tumor in a postmenopausal female--a case report. (15099979)
2004
21
Clinicopathological study of intermediate trophoblastic non-tumor lesions: exaggerated placental site and placental site nodule]. (15498215)
2004
22
Placental site trophoblastic tumor of the uterine cervix occurring from undetermined antecedent pregnancy. (15009614)
2004
23
Clinical-pathologic conference in general thoracic surgery: metastatic placental site trophoblastic tumor. (15001921)
2004
24
Placental site trophoblastic tumor arising from antecedent molar pregnancy. (14766272)
2004
25
Placental site trophoblastic tumor in a patient with brain and lung metastases. (15228435)
2004
26
Ultrasound diagnosis of uterine arteriovenous fistula associated with placental site trophoblastic tumor. (12808680)
2003
27
Placental site trophoblastic tumor. (12832940)
2003
28
Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center. (11520134)
2001
29
Placental site trophoblastic tumor metastasizing to the brain. Case illustration. (11147884)
2001
30
Pregnancy with primary tubal placental site trophoblastic tumor--A case report and literature review. (10329055)
1999
31
Successful treatment of malignant placental site trophoblastic tumor with combined cytostatic-surgical approach: case report and review of literature. (10502447)
1999
32
Placental site trophoblastic tumor: imaging findings. (10646979)
1999
33
Following metastatic placental site trophoblastic tumor with urine beta-core fragment. (10419751)
1999
34
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
35
Placental site trophoblastic tumor: human placental lactogen and pregnancy-associated major basic protein as immunohistologic markers. (9496832)
1998
36
Metastatic placental site trophoblastic tumor. (9833615)
1998
37
Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. (9808132)
1998
38
Immunohistochemical analysis of cell cycle regulatory gene products in normal trophoblast and placental site trophoblastic tumor. (9656119)
1998
39
Trophoblastic tumors of the testis other than classic choriocarcinoma: &quot;monophasic&quot; choriocarcinoma and placental site trophoblastic tumor: a report of two cases. (9060597)
1997
40
P53 gene product and EGF-receptor are highly expressed in placental site trophoblastic tumor. (9385938)
1997
41
Placental-site trophoblastic tumor. Principles of diagnosis, clinical behaviour and treatment. (7556286)
1995
42
Placental site trophoblastic tumor. Report of three cases and review of the literature. (11578484)
1995
43
Unusual endovaginal ultrasonography and magnetic resonance imaging of placental site trophoblastic tumor. (8141195)
1994
44
Metastasizing placental site trophoblastic tumor. An immunohistochemical and flow cytometric study of two cases. (8396853)
1993
45
Placental site trophoblastic tumor: a report of radiologic, surgical, and pathologic methods of evaluating the extent of disease. (8394275)
1993
46
Placental site trophoblastic tumor. Diagnosis, clinical behavior and treatment. (1848895)
1991
47
Placental site trophoblastic tumor associated with immature ovarian teratoma. (1972122)
1990
48
Ovarian conservation in placental site trophoblastic tumor. (2160904)
1990
49
Malignant placental site trophoblastic tumor. (2991836)
1985
50
Placental site trophoblastic tumor of the uterus: an ultrastructural and immunohistochemical study. (6091306)
1984

Genetic Variations for Placental Site Trophoblastic Tumor

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Expression for genes affiliated with Placental Site Trophoblastic Tumor

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Placental Site Trophoblastic Tumor

Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

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53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8CGB, CGA
29.6EGFR, EPO
39.6ERBB2, EGFR
4
Hide members
9.6ERBB2, EGFR
59.2ERBB2, EPO, EGFR
69.1ERBB2, GPC3, EGFR

Compounds for genes affiliated with Placental Site Trophoblastic Tumor

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1griseofulvin44 1111.0KRT18, CGA
2Afatinib119.9ERBB2, EGFR
3jnj 28871063 hydrochloride599.9EGFR, ERBB2
4ag 490599.9EGFR, ERBB2
5ag 1478 hydrochloride599.9EGFR, ERBB2
6iressa599.9EGFR, ERBB2
711-ketotestosterone449.9CGB5, CGA
8pd158780449.9EGFR, ERBB2
9pertuzumab44 49 1111.8ERBB2, EGFR
10pki-166449.7EGFR, ERBB2
11cycloheximide449.7ALPP, CGB5
12fulvestrant44 49 28 1112.7ERBB2, KRT18, EGFR
13anastrozole44 1110.7EGFR, CGA, ERBB2
14oestriol449.6CGB, CGB5, CGA
15letrozole44 49 59 1112.6ERBB2, CGA, EGFR
16quinazoline449.6ERBB2, EGFR
17vinorelbine44 1110.6EGFR, EPO, ERBB2
18ctp449.6CGB, CGB5, CGA
19clomiphene citrate449.6CGB, CGB5, CGA
20topotecan44 1110.6EGFR, EPO, ERBB2
21ifosfamide44 1110.6CGA, CGB5, CGB
22hrgbeta1449.5EGFR, ERBB2
23organon449.5CGA, CGB5
24cetrorelix44 28 1111.5CGB5, CGA, EGFR
25celecoxib44 59 28 49 11 2414.4EGFR, EPO, ERBB2
26tetracycline44 1110.4EGFR, KRT18, ERBB2
27androstenedione44 2410.4CGB, CGB5, CGA
28carboplatin44 49 1111.3ERBB2, EPO, CGA, EGFR
29bleomycin44 1110.2CGA, CGB5, CGB, EPO
30leucovorin44 49 1111.1EGFR, CGB5, CGB, ERBB2
31etoposide44 49 59 1112.1CGA, CGB5, CGB, ERBB2
32vitamin d449.1CGA, EPO, ERBB2, ALPP
33dmso449.0ALPP, KRT18, CGB5, CGA
34cyclophosphamide44 49 1110.9CGA, CGB5, CGB, KRT18, ERBB2
35aspartate448.9CGA, EPO, KRT18, ERBB2, ALPP
36methotrexate44 49 1110.8CGA, CGB5, CGB, EPO, ERBB2
37gnrh448.8CGA, CGB5, CGB, EPO, ERBB2
38doxorubicin44 49 1110.7EGFR, CGA, CGB5, KRT18, ERBB2
39ascorbic acid44 249.7CGA, CGB5, EPO, KRT18, ALPP
40folate448.6CGA, CGB5, EPO, ERBB2, ALPP
41progestin448.6EGFR, CGA, CGB5, ERBB2, ALPP
42tamoxifen44 49 28 1111.5EGFR, CGA, CGB5, ERBB2, ALPP
43progesterone44 59 28 11 2412.4EGFR, CGA, CGB5, CGB, KRT18, ERBB2
44creatinine448.4CGA, CGB5, CGB, EPO, KRT18, ALPP
45alanine448.3CGA, CGB, KRT18, ERBB2, ALPP
46paraffin448.2EGFR, CGA, CGB5, KRT18, ERBB2, ALPP
47lactate448.0CGA, CGB5, CGB, EPO, KRT18, ERBB2
48cisplatin44 49 59 1110.9EGFR, CGA, CGB5, CGB, EPO, ERBB2
49testosterone44 59 11 2410.6ALPP, EGFR, CGA, CGB5, CGB, EPO
50vegf447.6EGFR, CGA, CGB5, CGB, EPO, KRT18

GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

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16Gene Ontology
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Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.8CGB, CGA
2anatomical structure morphogenesisGO:0096538.7KRT18, GPC3, MCAM
3signal transductionGO:0071658.3EGFR, CGA, CGB, EPO, ERBB2

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.6ERBB2, EGFR
2transmembrane receptor protein tyrosine kinase activityGO:0047149.6ERBB2, EGFR
3hormone activityGO:0051799.4EPO, CGB, CGA
4receptor signaling protein tyrosine kinase activityGO:0047169.3ERBB2, EGFR

Products for genes affiliated with Placental Site Trophoblastic Tumor

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  • Antibodies
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  • Antibodies

Sources for Placental Site Trophoblastic Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet