MCID: PLC003
MIFTS: 50

Placental Site Trophoblastic Tumor malady

Categories: Rare diseases, Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Placental Site Trophoblastic Tumor

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Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 45NIH Rare Diseases, 47Novoseek, 36MeSH, 65UMLS, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Placental Site Trophoblastic Tumor:

Name: Placental Site Trophoblastic Tumor 10 12 51
Trophoblastic Tumor, Placental Site 36 65
Trophoblastic Tumor Placental Site 45 47
Placental-Site Gestational Trophoblastic Neoplasm 10
 
Placenta Neoplasm 45
Deciduoma 65
Psst 51

Characteristics:

Orphanet epidemiological data:

51
placental site trophoblastic tumor:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Disease Ontology10 DOID:3596
MeSH36 D018245
NCIt42 C3757
Orphanet51 99928
SNOMED-CT59 237252008, 75320001
UMLS via Orphanet66 C0206666
ICD10 via Orphanet28 D39.2
MESH via Orphanet37 D018245
ICD1027 C58
UMLS65 C0206666, C0524541

Summaries for Placental Site Trophoblastic Tumor

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Wikipedia:68 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

MalaCards based summary: Placental Site Trophoblastic Tumor, also known as trophoblastic tumor, placental site, is related to epithelioid trophoblastic tumor and flat ductal epithelial atypia, and has symptoms including abnormality of the menstrual cycle, spontaneous abortion and uterine neoplasm. An important gene associated with Placental Site Trophoblastic Tumor is INHA (Inhibin Alpha), and among its related pathways are Agrin Interactions at Neuromuscular Junction and Alzheimers Disease Pathway. Affiliated tissues include placenta, breast and lung, and related mouse phenotype cardiovascular system.

Related Diseases for Placental Site Trophoblastic Tumor

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Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid trophoblastic tumor30.6INHA, PAM
2flat ductal epithelial atypia10.5EGFR, ERBB2
3adenofibroma10.5EGFR, ERBB2
4her2-receptor positive breast cancer10.5EGFR, ERBB2
5situs inversus10.5EGFR, ERBB2
6spondylitis10.5EGFR, ERBB2
7high molecular weight kininogen deficiency10.5EGFR, ERBB2
8eccrine papillary adenocarcinoma10.5EGFR, ERBB2
9protein-deficiency anemia10.5EGFR, ERBB2
10nasal cavity squamous cell carcinoma10.5EGFR, ERBB2
11gastric cardia carcinoma10.4EGFR, ERBB2
12supernumerary nipples10.4CGB3, EGFR
13mediastinal neurilemmoma10.4EGFR, ERBB2
14lymphoepithelioma-like carcinoma10.4EGFR, ERBB2
15nonsyndromic hereditary sensorineural hearing loss10.4CGB5, ERBB2
16peritoneal cystic mesothelioma10.4EGFR, ERBB2
17cavernous hemangioma10.4EGFR, ERBB2
18scrotum paget's disease10.4EGFR, ERBB2
19nasal cavity adenocarcinoma10.4EGFR, ERBB2
20ampullary signet ring cell adenocarcinoma10.4EGFR, ERBB2
21epidermal nevus vitamin d resistant rickets10.4EGFR, ERBB2
22lymphatic system cancer10.4EGFR, ERBB2
23choriocarcinoma10.4
24sclerosing hemangioma10.4EGFR, ERBB2
25bacterial exanthem10.4EGFR, ERBB2
26progesterone-receptor negative breast cancer10.4EGFR, ERBB2
27eye carcinoma in situ10.3EGFR, ERBB2
28vascular dementia10.3EGFR, ERBB2
29familial cold autoinflammatory syndrome 210.3CGB3, CGB5
30ovary epithelial cancer10.3EGFR, ERBB2
31ovarian wilms' cancer10.3EGFR, ERBB2
32bronchogenic lung adenocarcinoma10.3EGFR, GPC3
33lupus erythematosus10.3EGFR, ERBB2
34ovarian primitive germ cell tumor10.3GPC3, INHA
35paroxysmal choreoathetosis10.3EGFR, ERBB2
36estrogen-receptor positive breast cancer10.2EGFR, ERBB2
37autosomal dominant sideroblastic anemia10.2CGB3, CGB5
38endometrial mucinous adenocarcinoma10.2ERBB2, INHA
39teratoma10.2
40gestational trophoblastic neoplasm10.1
41trophoblastic neoplasm10.1
42leigh syndrome10.1
43tenosynovitis of foot and ankle10.1EGFR, ERBB2, GPC3
44tracheal lymphoma10.1EGFR, ERBB2
45fallopian tube leiomyosarcoma10.1ERBB2, INHA
46breast hemangioma10.1CGB3, INHA
47ectopic pregnancy10.1
48leiomyoma10.1
49vaginitis10.1
50cervicitis10.1

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to placental site trophoblastic tumor

Symptoms for Placental Site Trophoblastic Tumor

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Symptoms:

 51 (show all 9)
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • neoplasms/tumors
  • uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer
  • antenatal period/pregnancy anomalies
  • spontaneous abortions
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Placental Site Trophoblastic Tumor:

(show all 7)
id Description Frequency HPO Source Accession
1 abnormality of the menstrual cycle hallmark (90%) HP:0000140
2 spontaneous abortion hallmark (90%) HP:0005268
3 uterine neoplasm hallmark (90%) HP:0010784
4 neoplasm of the liver occasional (7.5%) HP:0002896
5 neoplasm of the nervous system occasional (7.5%) HP:0004375
6 neoplasm of the lung occasional (7.5%) HP:0100526
7 vaginal neoplasm occasional (7.5%) HP:0100650

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

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Drugs for Placental Site Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Chorionic GonadotropinPhase 4173
2
Nitroglycerinapproved, investigationalPhase 213955-63-04510
Synonyms:
1,2,3-Propanetrioltrinitrate
1,2,3-Propanetriyl nitrate
100292-13-5
105469-31-6
55-63-0
80066-48-4
8013-23-8
9010-02-0
AC1L1IBV
Adesitrin
Aldonitrin
Angibid
Angiolingual
Angiplex
Anglix
Angonist
Angorin
Anogesic
Aquo-Trimitrosan
BIDD:GT0142
BRN 1802063
Blasting gelatin
Blasting oil
Buccal
Buccard
C07455
C3H5N3O9
CCRIS 4089
CHEBI:28787
CHEMBL730
CID4510
CPD-143
Cardabid
Cardamist
Cardinit
Cardiodisco
Cellegesic
Chitamite
Colenitral
Cordipatch
Corditrine
Coro-Nitro
D00515
D005996
DB00727
Dauxona
Deponit
Deponit 5
Deponit TTS 10
Deponit TTS 5
Deponit-5
Diafusor
Discotrine
Dynamite
EINECS 200-240-8
Epinitril
GTN
GTN-Pohl
Gepan Nitroglicerin
Gilucor nitro
Gilustenon
Glonoin
Glycerin trinitrate
Glycerine trinitrate
Glycerintrinitrate
Glycerol trinitrate
Glycerol, nitric acid triester
Glyceroli trinitratis
Glyceroltrinitraat
Glyceroltrinitrat
Glyceryl
Glyceryl nitrate
Glyceryl trinitrate
Glycerylnitrat
Glytrin
HMS2094M15
HSDB 30
Herwicard
Herzer
IMX-150
Klavikordal
LS-7741
Lenitral
Lentonitrina
MED-2002
MQX-503
Mi-Trates
Millisrol
Minitram
Minitran
Minitran (TN)
Minitro
Mionitrat
Myocon
Myoglycerin
Myovin
NG
NITRO IV
NK-843
NTG
Natispray
Neos nitro OPT
Niglin
Niglycon
Niong
Niong Retard
Nirmin
Nit-Ret
Nitora
Nitradisc
Nitradisc Pad
Nitradisc TTS
Nitrangin
Nitrek
Nitriderm
Nitriderm TTS
Nitrine-TDC
Nitro Bid
Nitro Dur
Nitro Dur TTS
Nitro Mack Retard
Nitro Retard
Nitro Rorer
Nitro-Bid
Nitro-Dur 10
Nitro-Dur 5
Nitro-Gesanit Retard
Nitro-M-Bid
Nitro-Mack Retard
Nitro-Par
Nitro-Pflaster
Nitro-Span
Nitro-Time
Nitro-bid
Nitro-bid (TN)
Nitro-dur
Nitro-dur (TN)
Nitro-lent
NitroBid
NitroCor
NitroDur
NitroMist
NitroQuick
 
NitroQuik
Nitroard
Nitrobaat
Nitrobid Oint
Nitrobukal
Nitrocap
NitrocapT.D
NitrocapT.D.
Nitrocard
Nitrocerin
Nitrocine
Nitrocine 5
Nitroclyn
Nitrocontin
Nitrocontin Continus
Nitrocot
Nitroderm
Nitroderm TTS
Nitroderm TTS Ext
Nitroderm TTS-5
Nitrodisc
Nitrodyl
Nitrodyl TTS
Nitrogard
Nitrogard-SR
Nitroglicerina
Nitrogliceryna
Nitroglin
Nitroglycerin
Nitroglycerin (NG)
Nitroglycerin ER
Nitroglycerin Lingual
Nitroglycerin Transdermal Delivery System
Nitroglycerin Transdermal System
Nitroglycerin ointment
Nitroglycerin-ACC
Nitroglycerine
Nitroglycerol
Nitroglyn
Nitroject
Nitrol Ointment
Nitrolan
Nitroletten
Nitrolin
Nitrolingual
Nitrolingual Pumpspray
Nitrolingual Spray
Nitrolowe
Nitromack Retard
Nitromed
Nitromel
Nitromex
Nitromint
Nitromint Aerosol
Nitromint Retard
Nitromist
Nitromist (TN)
Nitronal Aqueous
Nitronet
Nitrong
Nitrong Retard
Nitrong parenteral
Nitrong-SR
Nitropatch
Nitropen
Nitropercuten
Nitroperlinit
Nitroplast
Nitroprol
Nitropront
Nitroprontan
Nitrorectal
Nitroretard
Nitrorex
Nitrospan
Nitrostabilin
Nitrostat
Nitrovis
Nitrozell retard
Nysconitrine
Percutol
Percutol Oint
Percutol Oint.
Perganit
Perglottal
Perlinganit
Plastranit
Polnitrin
Propane-1,2,3-triyl trinitrate
RCRA waste no. P081
Ratiopharm
Rectiv
Rectogesic
SDM No. 17
SK-106N
SK-866
SK-878
Soup
Spirit of glonoin
Susadrin
Suscard
Sustac
Sustak
Sustonit
TNG
Temponitrin
Top-Nitro
Transderm Nitro
Transderm nitro
Transderm-N TTS
Transderm-Nitro TTS
Transderm-nitro
Transderm-nitro (TN)
Transiderm-nitro
Tridil
Tridil sublin
Trinalgon
Trinipatch
Triniplas
Trinitrate, Glyceryl
Trinitrin
Trinitrin Tablets
Trinitrina Erba
Trinitrine
Trinitroglycerin
Trinitroglycerol
Trinitrol
Trinitrolong
Trinitron
Trinitrosan
Turicard
UN0143
UN0144
UN1204
UN3064
UN3319
UNII-G59M7S0WS3
Vascana
Vasoglyn
Vasolator
Vernies
Willong
c0061
nitroglycerin
3
Bevacizumabapproved, investigationalPhase 21875216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
4ImmunoglobulinsPhase 24477
5AntibodiesPhase 24477
6Angiogenesis InhibitorsPhase 23688
7Angiogenesis Modulating AgentsPhase 23611

Interventional clinical trials:

idNameStatusNCT IDPhase
1Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for ChoriocarcinomaNot yet recruitingNCT00294177Phase 4
2Second Curettage in Treating Patients With Persistent Non-Metastatic Gestational Trophoblastic TumorRecruitingNCT00521118Phase 2
3Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)Not yet recruitingNCT02664961Phase 2

Search NIH Clinical Center for Placental Site Trophoblastic Tumor


Cochrane evidence based reviews: trophoblastic tumor, placental site

Genetic Tests for Placental Site Trophoblastic Tumor

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Anatomical Context for Placental Site Trophoblastic Tumor

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MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

33
Placenta, Breast, Lung, Liver, Uterus, Cervix, Heart

Animal Models for Placental Site Trophoblastic Tumor or affiliated genes

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MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.6EGFR, ERBB2, GPC3, INHA, LNPEP, PAM

Publications for Placental Site Trophoblastic Tumor

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Articles related to Placental Site Trophoblastic Tumor:

(show top 50)    (show all 163)
idTitleAuthorsYear
1
Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. (26261623)
2015
2
Placental site trophoblastic tumor presented with vaginal metastasis. (25932270)
2015
3
Lupus nephritis associated with placental site trophoblastic tumor: A case report and review of the literature. (24944882)
2014
4
Unsuccessful planned conservative resection of placental site trophoblastic tumor. (23344410)
2013
5
Diagnosis and treatment of placental site trophoblastic tumor. (23826431)
2013
6
Placental site trophoblastic tumor, report of a case with unusual presentation. (23478075)
2013
7
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. (23040933)
2012
8
Clinical features of 17 cases of placental site trophoblastic tumor. (21862010)
2011
9
Kidney involvement in a patient affected by placental site trophoblastic tumor. (21257242)
2011
10
Two cases of placental site trophoblastic tumor. (22030056)
2011
11
Placental site trophoblastic tumor--a challenging, rare entity. (21199764)
2010
12
Placental site trophoblastic tumor presenting as a friable cervical mass. (21061804)
2010
13
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. (20381116)
2010
14
Placental site trophoblastic tumor: lymphatic spread and possible target markers. (19910023)
2010
15
Placental site trophoblastic tumor. (19935163)
2009
16
Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. (19366068)
2009
17
Survival of placental-site trophoblastic tumor patients strongly linked with time since related pregnancy. (19670504)
2009
18
Placental-site trophoblastic tumors: a case of resistant pulmonary metastasis. (18227827)
2008
19
Absence of Y chromosome in human placental site trophoblastic tumor. (17643092)
2007
20
Fertility sparing therapy in a patient with placental site trophoblastic tumor: a case report. (17007914)
2006
21
Exclusion of lung metastases in placental site trophoblastic tumor using [18F]fluorodeoxyglucose positron emission tomography: a case report. (16051337)
2005
22
Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature. (15958158)
2005
23
p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. (15316317)
2004
24
Placental site trophoblastic tumor in a postmenopausal female--a case report. (15099979)
2004
25
Placental site trophoblastic tumor: an overview. (15457847)
2004
26
Placental site trophoblastic tumor of the uterine cervix occurring from undetermined antecedent pregnancy. (15009614)
2004
27
Ultrasound diagnosis of uterine arteriovenous fistula associated with placental site trophoblastic tumor. (12808680)
2003
28
Adrenal metastatic placental site trophoblastic tumor. Case report. (12744102)
2003
29
Placental site trophoblastic tumor. (12832940)
2003
30
Successful management of metastatic placental site trophoblastic tumor with multiple pulmonary resections. (12468357)
2002
31
Placental site trophoblastic tumor (PSTT) in mother and child: first report of PSTT in infancy. (11836719)
2002
32
Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center. (11520134)
2001
33
Spontaneous uterine perforation mimicking ectopic pregnancy as the initial presentation of placental site trophoblastic tumor. (11768287)
2001
34
Prolonged remission of recurrent, metastatic placental site trophoblastic tumor after chemotherapy. (10620452)
2000
35
Placental site trophoblastic tumor. Clinical and pathological report of two cases. (11173663)
2000
36
Failure of high-dose chemotherapy with peripheral blood stem cell support for refractory placental site trophoblastic tumor. (10087421)
1999
37
MR appearance of placental site trophoblastic tumor: a report of three cases. (9456970)
1998
38
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
39
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
40
Metastatic placental site trophoblastic tumor: long-term remission in a patient treated with EMA/CO chemotherapy. (9454662)
1998
41
Unusual endovaginal ultrasonography and magnetic resonance imaging of placental site trophoblastic tumor. (8141195)
1994
42
Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. (7691711)
1993
43
Metastasizing placental site trophoblastic tumor. An immunohistochemical and flow cytometric study of two cases. (8396853)
1993
44
Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor. (11576278)
1992
45
Erythrocytosis associated with a placental-site trophoblastic tumor. (1314361)
1992
46
Placental site trophoblastic tumor associated with immature ovarian teratoma. (1972122)
1990
47
Clinical characteristics of placental site trophoblastic tumor (PSTT). (2842238)
1988
48
Malignant placental site trophoblastic tumor. (2991836)
1985
49
Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. (6329973)
1984
50
Placental site trophoblastic tumor of the uterus: an ultrastructural and immunohistochemical study. (6091306)
1984

Variations for Placental Site Trophoblastic Tumor

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Expression for genes affiliated with Placental Site Trophoblastic Tumor

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Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for genes affiliated with Placental Site Trophoblastic Tumor

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GO Terms for genes affiliated with Placental Site Trophoblastic Tumor

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Cellular components related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:00163239.3EGFR, ERBB2

Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1SMAD protein signal transductionGO:00603959.9INHA, LNPEP
2peptide hormone processingGO:00164869.8CGB3, CGB5
3transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.6EGFR, ERBB2
4ERBB2 signaling pathwayGO:00381289.6EGFR, ERBB2
5positive regulation of cell growthGO:00303079.2EGFR, ERBB2
6cell-cell signalingGO:00072678.8CGB3, CGB5, INHA, LNPEP

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:00047169.3EGFR, ERBB2

Sources for Placental Site Trophoblastic Tumor

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet