Aliases & Classifications for Plagiocephaly

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Summaries for Plagiocephaly

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Wikipedia:69 Plagiocephaly, also known as flat head syndrome, is a condition characterized by an asymmetrical... more...

MalaCards based summary: Plagiocephaly is related to isolated plagiocephaly and plagiocephaly and x-linked mental retardation. An important gene associated with Plagiocephaly is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Endochondral Ossification. Affiliated tissues include brain, bone and testes, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Related Diseases for Plagiocephaly

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Diseases related to Plagiocephaly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1isolated plagiocephaly12.1
2plagiocephaly and x-linked mental retardation12.0
3mental retardation, x-linked, with craniofacial dysmorphism11.1
4hyde forster mccarthy berry syndrome10.9
5synostosis10.5
6craniosynostosis10.3
7lambdoid synostosis10.3
8strabismus10.2
9staphylococcal scarlet fever10.1FGFR3, TWIST1
10cervicitis10.1
11mite infestation10.0FGFR2, FGFR3
12apert syndrome10.0FGFR2, FGFR3
13accommodative esotropia10.0FGFR2, FGFR3
14muenke syndrome10.0
15brachycephaly, deafness, cataract, microstomia, and mental retardation10.0
16crouzon syndrome with acanthosis nigricans9.9FGFR2, FGFR3
17glaucomatocyclitic crisis9.9FGFR2, FGFR3
18scleredema adultorum9.9FGFR2, FGFR3
19sudden infant death syndrome9.8
20crouzon syndrome9.8
21otitis media9.8
22hemangioma9.8
23scoliosis9.8
24astigmatism9.8
25dysostosis9.8
26refractive error9.8
27osteopetrosis and infantile neuroaxonal dystrophy9.8FGFR1, FGFR3
28syphilitic myelopathy9.8FGFR1, FGFR3
29pfn1-related amyotrophic lateral sclerosis9.7FGFR1, FGFR2
30uterus bicornis bicollis with partial vaginal septum and unilateral hematocolpos with ipsilateral renal agenesis9.7FGFR1, FGFR2
31grade iii astrocytoma9.6FGFR1, FGFR3
32weill-marchesani syndrome9.6FGFR1, FGFR2
33serous conjunctivitis except viral9.6FGFR2, FGFR3
34progeria9.5FGFR1, FGFR2
35myasthenic syndrome, congenital, 2c, associated with acetylcholine receptor deficiency9.4FGFR1, FGFR2
36y-linked disease9.4FGFR2, FGFR3
37glycogen storage disease ix9.4FGFR1, FGFR2
38adult astrocytic tumour9.3FGFR1, FGFR3, TWIST1
39flnb-related disorders9.3FGFR1, FGFR2, FGFR3
40trigonocephaly 19.3FGFR1, FGFR2, FGFR3
41hypogonadotropic hypogonadism 2 with or without anosmia9.3FGFR1, FGFR2, FGFR3
42thanatophoric dysplasia, type i9.3FGFR1, FGFR2, FGFR3
43antley-bixler syndrome without genital anomalies or disordered steroidogenesis9.3FGFR1, FGFR2, FGFR3
44beare-stevenson cutis gyrata syndrome9.3FGFR1, FGFR2, FGFR3
45thanatophoric dysplasia, type ii9.3FGFR1, FGFR2, FGFR3
46hypochondroplasia9.2FGFR1, FGFR2, FGFR3
47plasmalogens synthesis deficiency isolated8.8FGFR1, FGFR2, FGFR3, TWIST1
48bladder cancer, somatic8.8FGFR1, FGFR2, FGFR3, TWIST1
49central nervous system leukemia8.8FGFR1, FGFR2, FGFR3, TWIST1
50ischemic bone disease8.8FGFR1, FGFR2, FGFR3, TWIST1

Graphical network of the top 20 diseases related to Plagiocephaly:



Diseases related to plagiocephaly

Symptoms for Plagiocephaly

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Drugs & Therapeutics for Plagiocephaly

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Drugs for Plagiocephaly (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Salicylic acid16569-72-7338
Synonyms:
105910_ALDRICH
105910_SIAL
2 Hydroxybenzoic Acid
2-Carboxyphenol
2-Hydroxybenzenecarboxylate
2-Hydroxybenzenecarboxylic acid
2-Hydroxybenzoate
2-Hydroxybenzoic acid
2-hydroxy(1-14c)benzoic acid
247588_SIAL
27301_SIAL
69-72-7
7681-06-3
8052-31-1
84210_FLUKA
84210_SIAL
AB1002436
AC1L190M
AC1Q1HCK
AC1Q72IF
AI3-02407
AKOS000118979
ALPHA/BETA HYDROXY ACIDS (SALICYLIC ACID) (SEE ALPHA/BETA HYDROXY ACIDS)
AR-1E2203
ATA fraction 10, ammonium salt
Acid, 2-Hydroxybenzoic
Acid, Salicylic
Acid, o-Hydroxybenzoic
Acid, ortho-Hydroxybenzoic
Acido o-idrossibenzoico
Acido o-idrossibenzoico [Italian]
Acido salicilico
Acido salicilico [Italian]
Acidum salicylicum
Advanced Pain Relief Callus Removers
Advanced Pain Relief Corn Removers
Advanced pain relief callus removers
Advanced pain relief corn removers
Akurza Cream
Akurza Lotion
Alpha/Beta Hydroxy Acids (Glycolic Acid, Salicylic Acid)
BENZOIC ACID,2-HYDROXY SALICYLIC ACID
BIDD:ER0602
BRN 0774890
Benzoic acid, 2-hydroxy- (9CI)
C00805
CCRIS 6714
CHEBI:16914
CHEMBL424
CID338
CMC_13852
Caswell No. 731
Clear away Wart Remover
Clear away wart remover
Compound W
Compound w
D00097
D020156
DB00936
DHS Sal Shampoo
DivK1c_000301
Domerine
Dr. Scholl'S Callus Removers
Dr. Scholl'S Corn Removers
Dr. Scholl'S Wart Remover Kit
Dr. Scholl's callus removers
Dr. Scholl's corn removers
Dr. Scholl's wart remover kit
DuoPlant Gel
Duofil Wart Remover
Duofil wart remover
Duofilm
Duoplant
E9A559BE-383B-4F83-BC02-3031D03D558A
EINECS 200-712-3
EPA Pesticide Chemical Code 076602
Freezone
H0206
HSDB 672
Hydrisalic Gel
I04-0192
IDI1_000301
InChI=1/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10
Ionil
Ionil Plus
Ionil plus
Ionil-Plus
 
K 537
K 557
KBio1_000301
KBio2_001428
KBio2_003996
KBio2_006564
KBioSS_001428
Keralyt
Kyselina 2-hydroxybenzoova
Kyselina 2-hydroxybenzoova [Czech]
Kyselina salicylova
Kyselina salicylova [Czech]
LS-2169
MLS000069653
Mediplast pads
MolPort-001-769-476
NCGC00159447-02
NCGC00159447-04
NINDS_000301
NSC 180
NSC180
NSC629474
O-Carboxyphenol
O-Hydroxybenzoate
O-Hydroxybenzoic acid
O-carboxyphenol
O-hydroxybenzoic acid
Occlusal
Oprea1_040343
Orthohydroxybenzoic acid
P&S Shampoo
Phenol-2-carboxylate
Phenol-2-carboxylic acid
Propa pH Peel-Off Acne Mask
Psoriacid-S-Stift
Psoriacid-S-stift
Retarder SAX
Retarder W
Rutranex
S5922_SIGMA
S7401_SIGMA
S8519_SIGMA
SALICYLIC ACID (SEE ALSO ALPHA HYDROXY ACIDS)
SALICYLIC ACID, ACS
SAX
SBB052826
SGCUT00012
SMP2_000145
SMR000059163
STK258681
Salex Cream
Salex Lotion
Salicyclic acid
Salicylate
Salicylic acid
Salicylic acid & Sulfur Soap
Salicylic acid (6CI,8CI)
Salicylic acid (JP15/USP)
Salicylic acid (TN)
Salicylic acid Soap
Salicylic acid [USAN:JAN]
Salicylic acid collodion
Salicylic acid soap
Salicylic acid, tech
Salicylic acid, tech.
Salicylic acid-ring-UL-14C
Saligel
Salonil
Sebucare
Sebulex
Spectrum_000948
Stri-Dex
Trans-Ver-Sal
UNII-O414PZ4LPZ
UPCMLD-DP126
UPCMLD-DP126:001
Verrugon
W398500_ALDRICH
WLN: QVR BQ
bmse000252
o Hydroxybenzoic Acid
o-Carboxyphenol
o-hydroxybenzoic acid
ortho Hydroxybenzoic Acid
ortho-Hydroxybenzoic Acid
phenol derivative, 7
salicylate
salicylic acid
to_000004

Interventional clinical trials:

idNameStatusNCT IDPhase
1Postural Assessment in PlagiocephalyCompletedNCT01989286
2Newborn Head Molding and Later AsymmetriesRecruitingNCT02283229
3Brain Characteristics Noted Prior to and Following TreatmentRecruitingNCT02392195
4Investigating the Effectiveness of Mobilization on Congenital Muscular Torticollis and Deformational PlagiocephalyRecruitingNCT02403011
5Osteopathic Approach Into Neonatology Ward: the NE-O ModelAvailableNCT01902563
6Investigating the Effectiveness of Control Frequency on and Deformational PlagiocephalyNot yet recruitingNCT02607969
7Cranial Orthotic Device Versus Repositioning Techniques for the Management of Plagiocephaly: the CRANIO Randomized TrialNot yet recruitingNCT02370901
8Cranial Cup Use for the Prevention of Positional Head Shape Deformity in the NICUTerminatedNCT01218087
9Hanger Helmet StudyWithdrawnNCT02561728

Search NIH Clinical Center for Plagiocephaly

Genetic Tests for Plagiocephaly

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Genetic tests related to Plagiocephaly:

id Genetic test Affiliating Genes
1 Plagiocephaly25

Anatomical Context for Plagiocephaly

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MalaCards organs/tissues related to Plagiocephaly:

34
Brain, Bone, Testes, Eye, Heart

Animal Models for Plagiocephaly or affiliated genes

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MGI Mouse Phenotypes related to Plagiocephaly:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.8FGFR1, FGFR2, FGFR3
2MP:00053828.2FGFR1, FGFR2, FGFR3, TWIST1
3MP:00053818.1FGFR1, FGFR2, FGFR3, TWIST1
4MP:00053908.0FGFR1, FGFR2, FGFR3, TWIST1
5MP:00053717.7FGFR1, FGFR2, FGFR3, TWIST1

Publications for Plagiocephaly

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Articles related to Plagiocephaly:

(show top 50)    (show all 343)
idTitleAuthorsYear
1
Malocclusion in the primary dentition in children with and without deformational plagiocephaly. (26795625)
2016
2
Therapy effects of head orthoses in positional plagiocephaly. (27595189)
2016
3
Clinical assessment of head orientation profile development and its relationship with positional plagiocephaly in healthy term infants - A prospective study. (27031440)
2016
4
Preventing deformational plagiocephaly through parent guidance: a randomized, controlled trial. (25823758)
2015
5
Lambdoid Synostosis Versus Positional Posterior Plagiocephaly, a Comparison of Skull Base and Shape of Calvarium Using Computed Tomography Imaging. (26335322)
2015
6
The usage of the three-dimension distractor in the NAVID system for plagiocephaly-three case reports. (26188775)
2015
7
Isolated frontosphenoidal synostosis: a rare cause of synostotic frontal plagiocephaly. (24606403)
2014
8
Management of positional plagiocephaly--helmet or no helmet? (24864022)
2014
9
A complicated case of plagiocephaly followed by delayed craniosynostosis. (23595804)
2013
10
Comparison of helmet therapy and counter positioning for deformational plagiocephaly. (24466513)
2013
11
Development at age 36 months in children with deformational plagiocephaly. (23266929)
2013
12
A modified approach to surgical correction of anterior plagiocephaly. (23997494)
2012
13
Positional plagiocephaly and excessive folic Acid intake during pregnancy. (21740174)
2012
14
Increased incidence of metopic suture abnormalities in children with positional plagiocephaly. (21187772)
2011
15
Exploring the impact of osteopathic treatment on cranial asymmetries associated with nonsynostotic plagiocephaly in infants. (21982132)
2011
16
Severe deformational plagiocephaly: long-term results of surgical treatment. (21187754)
2011
17
Developing guidelines for child health care nurses to prevent nonsynostotic plagiocephaly: searching for the evidence. (21726785)
2011
18
Prevalence, risk factors, and natural history of positional plagiocephaly: a systematic review. (18754894)
2008
19
Plagiocephaly, brachycephaly and cranial orthotic devices: misshapen heads and helmets. (18719162)
2008
20
Comparison of a modifiable cranial cup versus repositioning and cervical stretching for the early correction of deformational posterior plagiocephaly. (18317143)
2008
21
The misdiagnosis of craniosynostosis as deformational plagiocephaly. (18216678)
2008
22
Frontosphenoidal synostosis: a rare cause of unilateral anterior plagiocephaly. (17891404)
2007
23
Posterior positional plagiocephaly treated with cranial remodeling orthosis. (17629800)
2007
24
Postoperative cognitive outcome for synostotic frontal plagiocephaly. (16871865)
2006
25
Neurodevelopment delays in children with deformational plagiocephaly. (16932202)
2006
26
Quantifying positional plagiocephaly: reliability and validity of anthropometric measurements. (16770174)
2006
27
Cranial distraction for plagiocephaly: quantitative morphologic analyses of cranium using three-dimensional computed tomography and a life-size model. (16077318)
2005
28
Parental satisfaction with the CranioCap: a new cranial orthosis for deformational plagiocephaly. (16001912)
2005
29
Molding helmet therapy in the treatment of brachycephaly and plagiocephaly. (14704577)
2004
30
Determinants of nonsynostotic plagiocephaly: a case-control study. (14523218)
2003
31
Deformational posterior plagiocephaly: diagnosis and treatment. (12401104)
2002
32
Study of asymmetries of the cranial vault in plagiocephaly. (12218795)
2002
33
Multiple-birth infants at higher risk for development of deformational plagiocephaly: II. is one twin at greater risk? (11773537)
2002
34
Skeletal analysis of craniofacial deformities in brachycephaly: comparison with craniofacial deformities in plagiocephaly. (11484526)
2001
35
Neurodevelopment in children with single-suture craniosynostosis and plagiocephaly without synostosis. (11711916)
2001
36
Update on craniofacial surgery: the differential diagnosis of lambdoid synostosis/posterior plagiocephaly. (11197708)
2000
37
Ocular plagiocephaly: Author's reply (11097576)
2000
38
Positional plagiocephaly: a community approach to prevention and treatment. (10602685)
1999
39
Pediatric management problems. Plagiocephaly. (9555451)
1998
40
Diagnosis and management of posterior plagiocephaly. (9024443)
1997
41
A novel mutation (a886g) in exon 5 of FGFR2 in members of a family with Crouzon phenotype and plagiocephaly. (9152842)
1997
42
Synostotic frontal plagiocephaly: anthropometric comparison of three techniques for surgical correction. (9385949)
1997
43
Surgical correction of posterior plagiocephaly: original technique. (9105384)
1997
44
A prospective study of the relationship between strabismus and head posture in patients with frontal plagiocephaly. (8618990)
1996
45
Surgery for unilateral coronal synostosis (plagiocephaly): unilateral or bilateral correction? (9133833)
1996
46
Lambdoid stenosis (posterior plagiocephaly) and craniofacial asymmetry: long-term outcomes. (9118137)
1996
47
Refractive error and ocular motility in plagiocephaly. (7923229)
1994
48
Ocular manifestations of deformational frontal plagiocephaly. (8501624)
1993
49
Orbital expansion in plagiocephaly. (3345403)
1988
50
A Case of Plagiocephaly. (16692731)
1926

Variations for Plagiocephaly

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Expression for genes affiliated with Plagiocephaly

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Search GEO for disease gene expression data for Plagiocephaly.

Pathways for genes affiliated with Plagiocephaly

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Pathways related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathwaysScoreTop Affiliating Genes
19.1FGFR1, FGFR3
29.1FGFR1, FGFR3
39.0FGFR1, FGFR2
4
Show member pathways
8.5FGFR1, FGFR2, FGFR3
58.5FGFR1, FGFR2, FGFR3
68.5FGFR1, FGFR2, FGFR3
7
Show member pathways
8.5FGFR1, FGFR2, FGFR3
88.5FGFR1, FGFR2, FGFR3
9
Show member pathways
8.5FGFR1, FGFR2, FGFR3
10
Show member pathways
8.5FGFR1, FGFR2, FGFR3
11
Show member pathways
8.5FGFR1, FGFR2, FGFR3
12
Show member pathways
8.5FGFR1, FGFR2, FGFR3
13
Show member pathways
8.5FGFR1, FGFR2, FGFR3
14
Show member pathways
8.5FGFR1, FGFR2, FGFR3
15
Show member pathways
8.5FGFR1, FGFR2, FGFR3
16
Show member pathways
8.5FGFR1, FGFR2, FGFR3
178.5FGFR1, FGFR2, FGFR3
18
Show member pathways
8.5FGFR1, FGFR2, FGFR3
198.5FGFR1, FGFR2, FGFR3
208.5FGFR1, FGFR2, FGFR3
21
Show member pathways
8.5FGFR1, FGFR2, FGFR3
228.5FGFR1, FGFR2, FGFR3
238.5FGFR1, FGFR2, FGFR3
248.5FGFR1, FGFR2, FGFR3
258.5FGFR1, FGFR2, FGFR3
26
Show member pathways
8.5FGFR1, FGFR2, FGFR3
27
Show member pathways
8.5FGFR1, FGFR2, FGFR3
28
Show member pathways
8.5FGFR1, FGFR2, FGFR3
29
Show member pathways
8.5FGFR1, FGFR2, FGFR3
30
Show member pathways
8.5FGFR1, FGFR2, FGFR3
31
Show member pathways
8.5FGFR1, FGFR2, FGFR3
32
Show member pathways
8.5FGFR1, FGFR2, FGFR3
338.0FGFR1, FGFR2, FGFR3, TWIST1

GO Terms for genes affiliated with Plagiocephaly

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Cellular components related to Plagiocephaly according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic, membrane-bounded vesicleGO:00160239.0FGFR1, FGFR2

Biological processes related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1bone developmentGO:00603489.9FGFR2, TWIST1
2odontogenesisGO:00424769.9FGFR2, TWIST1
3outer ear morphogenesisGO:00424739.8FGFR1, TWIST1
4bone mineralizationGO:00302829.8FGFR2, FGFR3
5fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:00356079.8FGFR1, FGFR2
6embryonic cranial skeleton morphogenesisGO:00487019.8FGFR2, TWIST1
7negative regulation of osteoblast differentiationGO:00456689.7FGFR1, TWIST1
8bone morphogenesisGO:00603499.7FGFR2, FGFR3
9positive regulation of epithelial cell proliferationGO:00506799.7FGFR2, TWIST1
10mesenchymal cell differentiationGO:00487629.7FGFR1, FGFR2
11chondrocyte differentiationGO:00020629.7FGFR1, FGFR3
12positive regulation of cardiac muscle cell proliferationGO:00600459.7FGFR1, FGFR2
13positive regulation of cell cycleGO:00457879.6FGFR1, FGFR2
14skeletal system morphogenesisGO:00487059.6FGFR1, FGFR2
15branching involved in salivary gland morphogenesisGO:00604459.6FGFR1, FGFR2
16positive regulation of mesenchymal cell proliferationGO:00020539.6FGFR1, FGFR2
17ventricular zone neuroblast divisionGO:00218479.6FGFR1, FGFR2
18embryonic limb morphogenesisGO:00303269.5FGFR1, TWIST1
19midbrain developmentGO:00309019.5FGFR1, FGFR2
20skeletal system developmentGO:00015019.5FGFR1, FGFR3
21lung developmentGO:00303249.5FGFR1, FGFR2
22ureteric bud developmentGO:00016579.5FGFR1, FGFR2
23inner ear morphogenesisGO:00424729.4FGFR1, FGFR2
24lung-associated mesenchyme developmentGO:00604849.2FGFR1, FGFR2
25phosphatidylinositol-3-phosphate biosynthetic processGO:00360929.2FGFR1, FGFR2, FGFR3
26phosphatidylinositol phosphorylationGO:00468549.1FGFR1, FGFR2, FGFR3
27neuron migrationGO:00017649.1FGFR1, TWIST1
28regulation of phosphatidylinositol 3-kinase signalingGO:00140669.1FGFR1, FGFR2, FGFR3
29orbitofrontal cortex developmentGO:00217699.1FGFR1, FGFR2
30phosphatidylinositol-mediated signalingGO:00480159.1FGFR1, FGFR2, FGFR3
31fibroblast growth factor receptor signaling pathwayGO:00085439.1FGFR1, FGFR2, FGFR3
32positive regulation of phospholipase activityGO:00105189.1FGFR1, FGFR2, FGFR3
33in utero embryonic developmentGO:00017019.1FGFR1, FGFR2, TWIST1
34protein autophosphorylationGO:00467779.0FGFR1, FGFR2, FGFR3
35peptidyl-tyrosine phosphorylationGO:00181089.0FGFR1, FGFR2, FGFR3
36MAPK cascadeGO:00001658.9FGFR1, FGFR2, FGFR3
37positive regulation of MAPK cascadeGO:00434108.9FGFR1, FGFR2, FGFR3
38positive regulation of GTPase activityGO:00435478.6FGFR1, FGFR2, FGFR3
39negative regulation of transcription from RNA polymerase II promoterGO:00001228.4FGFR1, FGFR2, TWIST1
40positive regulation of cell proliferationGO:00082848.2FGFR1, FGFR2, FGFR3

Molecular functions related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:00050079.2FGFR1, FGFR2, FGFR3
21-phosphatidylinositol-3-kinase activityGO:00163039.1FGFR1, FGFR2, FGFR3
3phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.0FGFR1, FGFR2, FGFR3
4fibroblast growth factor bindingGO:00171348.9FGFR1, FGFR2, FGFR3
5protein tyrosine kinase activityGO:00047138.9FGFR1, FGFR2, FGFR3
6Ras guanyl-nucleotide exchange factor activityGO:00050888.8FGFR1, FGFR2, FGFR3
7protein homodimerization activityGO:00428038.5FGFR1, FGFR2, TWIST1

Sources for Plagiocephaly

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet