Aliases & Classifications for Plagiocephaly

Summaries for Plagiocephaly

MalaCards based summary : Plagiocephaly is related to isolated plagiocephaly and strabismus. An important gene associated with Plagiocephaly is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are Cytokine Signaling in Immune system and GAB1 signalosome. The drug Salicylic acid has been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotypes are Decreased human cytomegalovirus (HCMV) strain AD169 replication and Decreased substrate adherent cell growth

Wikipedia : 72 Plagiocephaly, also known as flat head syndrome, is a condition characterized by an asymmetrical... more...

Related Diseases for Plagiocephaly

Diseases related to Plagiocephaly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 isolated plagiocephaly 33.4 FGFR3 TWIST1
2 strabismus 30.0 FGFR2 FGFR3
3 muenke syndrome 29.9 FGFR1 FGFR2 FGFR3 TWIST1
4 dysostosis 29.3 FGFR2 FGFR3
5 synostosis 29.3 FGFR1 FGFR2 FGFR3 TWIST1
6 craniosynostosis 29.0 FGFR1 FGFR2 FGFR3 TWIST1
7 crouzon syndrome 28.8 FGFR1 FGFR2 FGFR3
8 x-linked intellectual disability-plagiocephaly syndrome 12.2
9 lambdoid synostosis 11.3
10 mental retardation, x-linked, with craniofacial dysmorphism 11.1
11 iqsec2 10.9
12 faciocardiorenal syndrome 10.9
13 brachycephaly, deafness, cataract, microstomia, and mental retardation 10.9
14 torticollis 10.4
15 aging 10.3
16 isolated brachycephaly 10.1 FGFR3 TWIST1
17 blood group, i system 10.0
18 cervicitis 10.0
19 luteoma 10.0 FGFR2 FGFR3
20 beare-stevenson cutis gyrata syndrome 10.0 FGFR2 FGFR3
21 hypertelorism 10.0 FGFR2 TWIST1
22 thanatophoric dysplasia, type i 10.0 FGFR2 FGFR3
23 hypertropia 10.0 FGFR2 FGFR3
24 acanthosis nigricans 9.9 FGFR2 FGFR3
25 chromosome 2q35 duplication syndrome 9.9 FGFR2 FGFR3
26 porokeratosis 9.9 FGFR2 FGFR3
27 autosomal dominant disease 9.9 FGFR2 FGFR3
28 synovial chondromatosis 9.8 FGFR1 FGFR3
29 osteochondroma 9.8 FGFR1 FGFR3
30 astigmatism 9.8
31 hemangioma 9.8
32 scoliosis 9.8
33 craniosynostosis 1 9.8
34 heart disease 9.8
35 hemifacial microsomia 9.8
36 otitis media 9.8
37 refractive error 9.8
38 sudden infant death syndrome 9.8
39 giant cell glioblastoma 9.8 FGFR1 FGFR3
40 radioulnar synostosis 9.8 FGFR1 FGFR2
41 antley-bixler syndrome 9.7 FGFR1 FGFR2
42 cleft palate, isolated 9.6 FGFR1 FGFR2
43 orofacial cleft 9.5 FGFR1 FGFR2
44 hydrocephalus 9.5 FGFR2 FGFR3
45 gliosarcoma 9.5 FGFR1 FGFR3 TWIST1
46 tooth agenesis 9.4 FGFR1 FGFR2
47 osteoglophonic dysplasia 9.4 FGFR1 FGFR2 FGFR3
48 jackson-weiss syndrome 9.4 FGFR1 FGFR2 FGFR3
49 hypochondroplasia 9.4 FGFR1 FGFR2 FGFR3
50 lacrimoauriculodentodigital syndrome 9.4 FGFR1 FGFR2 FGFR3

Graphical network of the top 20 diseases related to Plagiocephaly:



Diseases related to Plagiocephaly

Symptoms & Phenotypes for Plagiocephaly

GenomeRNAi Phenotypes related to Plagiocephaly according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.13 FGFR1 FGFR2 FGFR3
2 Decreased substrate adherent cell growth GR00193-A-2 8.8 FGFR2
3 Decreased substrate adherent cell growth GR00193-A-3 8.8 FGFR2 FGFR3

MGI Mouse Phenotypes related to Plagiocephaly:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.62 FGFR2 FGFR3 TWIST1 FGFR1
2 digestive/alimentary MP:0005381 9.56 FGFR1 FGFR2 FGFR3 TWIST1
3 hearing/vestibular/ear MP:0005377 9.33 FGFR1 FGFR2 FGFR3
4 limbs/digits/tail MP:0005371 9.26 FGFR2 FGFR3 TWIST1 FGFR1
5 skeleton MP:0005390 8.92 FGFR1 FGFR2 FGFR3 TWIST1

Drugs & Therapeutics for Plagiocephaly

Drugs for Plagiocephaly (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338

Interventional clinical trials:

(show all 11)

# Name Status NCT ID Phase Drugs
1 Investigating the Effectiveness of Control Frequency on and Deformational Plagiocephaly Unknown status NCT02607969
2 Investigating the Effectiveness of Mobilization on Congenital Muscular Torticollis and Deformational Plagiocephaly Unknown status NCT02403011
3 Postural Assessment in Plagiocephaly Completed NCT01989286
4 Premie Pouch to Manage Deformational Plagiocephaly in Very Low Birth Weight Infants Active, not recruiting NCT03184441
5 Newborn Head Molding and Later Asymmetries Active, not recruiting NCT02283229
6 Brain Characteristics Noted Prior to and Following Treatment Active, not recruiting NCT02392195
7 Osteopathic Approach Into Neonatology Ward: the NE-O Model Available NCT01902563
8 Effect of Usage Time of Helmet in Babies With Deformational Plagiocephaly Not yet recruiting NCT03430739
9 Cranial Orthotic Device Versus Repositioning Techniques for the Management of Plagiocephaly: the CRANIO Randomized Trial Not yet recruiting NCT02370901
10 Cranial Cup Use for the Prevention of Positional Head Shape Deformity in the NICU Terminated NCT01218087
11 Hanger Helmet Study Withdrawn NCT02561728

Search NIH Clinical Center for Plagiocephaly

Genetic Tests for Plagiocephaly

Genetic tests related to Plagiocephaly:

# Genetic test Affiliating Genes
1 Plagiocephaly 28

Anatomical Context for Plagiocephaly

MalaCards organs/tissues related to Plagiocephaly:

38
Brain, Bone, Testes, Eye, Heart

Publications for Plagiocephaly

Articles related to Plagiocephaly:

(show top 50) (show all 384)
# Title Authors Year
1
A Clinical Photographic Method to Evaluate the Need for Helmet Therapy in Deformational Plagiocephaly. ( 29194259 )
2018
2
Analysis of the correlation between deformational plagiocephaly and neurodevelopment delay: Methodological issues. ( 29246736 )
2018
3
Preventing "Flat-headed" Babies: A Commentary on "Impact of Parent Practices of Infant Positioning on Head Orientation Profile and Development of Positional Plagiocephaly in Healthy Term Infants". ( 29372872 )
2018
4
Craniofacial Distraction in the Management of Anterior Plagiocephaly: A Novel Idea and a Systematic Review of the Literature. ( 29408824 )
2018
5
Analysis of the correlation between deformational plagiocephaly and neurodevelopmental delay. ( 28958569 )
2018
6
Evaluation of positional plagiocephaly: Conventional anthropometric measurement versus laser scanning method. ( 29137851 )
2018
7
Analysis of the correlation between deformational plagiocephaly and neurodevelopment delay: Methodological issues. ( 29229424 )
2018
8
Facial asymmetry correction with moulded helmet therapy in infants with deformational skull base plagiocephaly. ( 29221913 )
2018
9
A New Operative One-Wing Technique to Correct Fronto-Orbital Region in Unilateral Nonsyndromic Plagiocephaly. ( 29065042 )
2018
10
Six month-old infants with deformational plagiocephaly do not differ from unaffected infants with respect to vocal control. ( 29106864 )
2017
11
Factors influencing outcomes of the treatment of positional plagiocephaly in infants: a 7-year experience. ( 28084921 )
2017
12
Does shape affect function? Articulatory skills in babbling of infants with deformational plagiocephaly. ( 28875353 )
2017
13
Plagiocephaly and Developmental Delay: A Systematic Review. ( 28009719 )
2017
14
Head Orthosis Therapy in Positional Plagiocephaly: Influence of Age and Severity of Asymmetry on Effect and Duration of Therapy. ( 28746283 )
2017
15
Plagiocephaly Severity Scale to Aid in Clinical Treatment Recommendations. ( 28468155 )
2017
16
Discussion: Head Orthosis Therapy in Positional Plagiocephaly: Influence of Age and Severity of Asymmetry on Effect and Duration of Therapy. ( 28746284 )
2017
17
The functional manual therapy intervention in infants with nonsynostotic plagiocephaly: a pilot study. ( 29072040 )
2017
18
Unicoronal Craniosynostosis and Plagiocephaly Correction with Fronto-orbital Bone Remodeling and Advancement. ( 28713746 )
2017
19
The Role of Age and Initial Deformation on Final Cranial Asymmetry in Infants with Plagiocephaly Treated with Helmet Therapy. ( 28850946 )
2017
20
The health belief model and factors associated with adherence to treatment recommendations for positional plagiocephaly. ( 28084919 )
2017
21
Deformational Plagiocephaly: A Review. ( 29394478 )
2017
22
Positional plagiocephaly is associated with sternocleidomastoid muscle activation in healthy term infants. ( 28236068 )
2017
23
Comparison of endocranial morphology according to age in one-piece fronto-orbital advancement using a distraction in craniosynostotic plagiocephaly. ( 28724507 )
2017
24
Deformational plagiocephaly in normal infants: a systematic review of causes and hypotheses. ( 28104626 )
2017
25
Accuracy of measurements used to quantify cranial asymmetry inA deformational plagiocephaly. ( 28615136 )
2017
26
Relationship between starting age of cranial-remolding-orthosis therapy and effectiveness of treatment in children with deformational plagiocephaly. ( 28484866 )
2017
27
Impact of Parent Practices of Infant Positioning on Head Orientation Profile and Development of Positional Plagiocephaly in Healthy Term Infants. ( 28375778 )
2017
28
Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Management of Patients With Positional Plagiocephaly: The Role of Physical Therapy. ( 27759674 )
2016
29
Therapy effects of head orthoses in positional plagiocephaly. ( 27595189 )
2016
30
Positional plagiocephaly following ventriculoperitoneal shunting in neonates and infancy-how serious is it? ( 27848003 )
2016
31
An Evidence-Based Approach to Nonsynostotic Plagiocephaly. ( 27673539 )
2016
32
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Management of Patients With Positional Plagiocephaly: The Role of Repositioning. ( 27776087 )
2016
33
Impact of severity and therapy onset on helmet therapy in positional plagiocephaly. ( 26724211 )
2016
34
Long-Term Assessment of Suturectomy in Trigonocephaly and Anterior Plagiocephaly. ( 27092924 )
2016
35
Malocclusion in the primary dentition in children with and without deformational plagiocephaly. ( 26795625 )
2016
36
Use of external orthotic helmet therapy in positional plagiocephaly. ( 26947339 )
2016
37
Evidence for Use of Frontozygomaticus and Contralateral Eurion as Hand-Caliper Landmarks for Assessment of Deformational Plagiocephaly. ( 27428906 )
2016
38
Assessment of Deformational Plagiocephaly Severity and Neonatal Developmental Delay. ( 27557465 )
2016
39
Systematic Review and Evidence-Based Guidelines for the Management of Patients with Positional Plagiocephaly. ( 27940801 )
2016
40
Clinical assessment of head orientation profile development and its relationship with positional plagiocephaly in healthy term infants - A prospective study. ( 27031440 )
2016
41
Repercussions of plagiocephaly on posture, muscle flexibility and balance in children aged 3-5a88years old. ( 27329908 )
2016
42
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Management of Patients With Positional Plagiocephaly: Executive Summary. ( 27759671 )
2016
43
Neurological assessment of Chinese infants with positional plagiocephaly using a Chinese version of the Infant Neurological International Battery (INFANIB). ( 27718070 )
2016
44
Effect of fronto-orbital advancement on astigmatism in patients with anterior plagiocephaly. ( 27567360 )
2016
45
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Diagnosis of Patients With Positional Plagiocephaly: The Role of Imaging. ( 27776086 )
2016
46
Sonographic Analysis of Changes in Skull Shape After Cranial Molding Helmet Therapy in Infants With Deformational Plagiocephaly. ( 26928929 )
2016
47
Quantitative analysis of craniofacial dysmorphology in infants with anterior synostotic plagiocephaly. ( 27541866 )
2016
48
Assessment of Deformational Plagiocephaly Severity and Neonatal Developmental Delay. ( 28005729 )
2016
49
Assessing the Cervical Range of Motion in Infants With Positional Plagiocephaly. ( 27192654 )
2016
50
Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Management of Patients With Positional Plagiocephaly: The Role of Repositioning. ( 27759673 )
2016

Variations for Plagiocephaly

Expression for Plagiocephaly

Search GEO for disease gene expression data for Plagiocephaly.

Pathways for Plagiocephaly

Pathways related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 FGFR1 FGFR2 FGFR3 TWIST1
2
Show member pathways
12.78 FGFR1 FGFR2 FGFR3
3
Show member pathways
12.73 FGFR1 FGFR2 FGFR3
4
Show member pathways
12.72 FGFR1 FGFR2 FGFR3
5
Show member pathways
12.71 FGFR1 FGFR2 FGFR3
6
Show member pathways
12.66 FGFR1 FGFR2 FGFR3
7
Show member pathways
12.65 FGFR1 FGFR2 FGFR3
8
Show member pathways
12.56 FGFR1 FGFR2 FGFR3
9 12.53 FGFR1 FGFR2 FGFR3
10 12.46 FGFR1 FGFR2 FGFR3
11
Show member pathways
12.43 FGFR1 FGFR2 FGFR3
12
Show member pathways
12.43 FGFR1 FGFR2 FGFR3
13
Show member pathways
12.39 FGFR1 FGFR2 FGFR3
14 12.33 FGFR1 FGFR2 FGFR3
15
Show member pathways
12.27 FGFR1 FGFR2 FGFR3
16
Show member pathways
12.2 FGFR1 FGFR2 FGFR3
17
Show member pathways
12.14 FGFR1 FGFR2 FGFR3
18
Show member pathways
12.12 FGFR1 FGFR2 FGFR3
19
Show member pathways
12.07 FGFR1 FGFR2 FGFR3
20
Show member pathways
12.07 FGFR1 FGFR2 FGFR3
21
Show member pathways
11.94 FGFR1 FGFR2 FGFR3
22
Show member pathways
11.93 FGFR1 FGFR2 FGFR3
23
Show member pathways
11.88 FGFR1 FGFR2 FGFR3
24
Show member pathways
11.81 FGFR1 FGFR2 FGFR3
25 11.74 FGFR1 FGFR2 FGFR3
26 11.69 FGFR1 FGFR2 FGFR3
27 11.54 FGFR1 FGFR3
28 11.45 FGFR1 FGFR3
29 11.44 FGFR1 FGFR2 FGFR3
30 11.28 FGFR1 FGFR2
31 11.25 FGFR1 FGFR2 FGFR3
32 11.09 FGFR1 FGFR2 FGFR3
33 10.99 FGFR1 FGFR2 FGFR3
34 10.93 FGFR1 FGFR2 FGFR3 TWIST1
35 10.76 FGFR1 FGFR2 FGFR3
36 10.72 FGFR1 FGFR2 FGFR3

GO Terms for Plagiocephaly

Cellular components related to Plagiocephaly according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 8.8 FGFR1 FGFR2 FGFR3

Biological processes related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.85 FGFR1 FGFR2 TWIST1
2 phosphorylation GO:0016310 9.85 FGFR1 FGFR2 FGFR3
3 protein phosphorylation GO:0006468 9.84 FGFR1 FGFR2 FGFR3
4 positive regulation of cell proliferation GO:0008284 9.84 FGFR1 FGFR2 FGFR3
5 MAPK cascade GO:0000165 9.75 FGFR1 FGFR2 FGFR3
6 in utero embryonic development GO:0001701 9.74 FGFR1 FGFR2 TWIST1
7 protein autophosphorylation GO:0046777 9.73 FGFR1 FGFR2 FGFR3
8 peptidyl-tyrosine phosphorylation GO:0018108 9.72 FGFR1 FGFR2 FGFR3
9 positive regulation of protein kinase B signaling GO:0051897 9.7 FGFR1 FGFR2 FGFR3
10 skeletal system development GO:0001501 9.68 FGFR1 FGFR3
11 neuron migration GO:0001764 9.68 FGFR1 TWIST1
12 lung development GO:0030324 9.67 FGFR1 FGFR2
13 positive regulation of epithelial cell proliferation GO:0050679 9.66 FGFR2 TWIST1
14 inner ear morphogenesis GO:0042472 9.65 FGFR1 FGFR2
15 bone development GO:0060348 9.65 FGFR2 TWIST1
16 embryonic limb morphogenesis GO:0030326 9.65 FGFR1 TWIST1
17 ureteric bud development GO:0001657 9.64 FGFR1 FGFR2
18 skeletal system morphogenesis GO:0048705 9.64 FGFR1 FGFR2
19 chondrocyte differentiation GO:0002062 9.63 FGFR1 FGFR3
20 positive regulation of cell cycle GO:0045787 9.63 FGFR1 FGFR2
21 midbrain development GO:0030901 9.62 FGFR1 FGFR2
22 positive regulation of cardiac muscle cell proliferation GO:0060045 9.62 FGFR1 FGFR2
23 embryonic cranial skeleton morphogenesis GO:0048701 9.61 FGFR2 TWIST1
24 bone mineralization GO:0030282 9.61 FGFR2 FGFR3
25 phosphatidylinositol phosphorylation GO:0046854 9.61 FGFR1 FGFR2 FGFR3
26 odontogenesis GO:0042476 9.6 FGFR2 TWIST1
27 bone morphogenesis GO:0060349 9.59 FGFR2 FGFR3
28 positive regulation of mesenchymal cell proliferation GO:0002053 9.58 FGFR1 FGFR2
29 positive regulation of MAPK cascade GO:0043410 9.58 FGFR1 FGFR2 FGFR3
30 branching involved in salivary gland morphogenesis GO:0060445 9.54 FGFR1 FGFR2
31 fibroblast growth factor receptor signaling pathway GO:0008543 9.54 FGFR1 FGFR2 FGFR3
32 mesenchymal cell differentiation GO:0048762 9.51 FGFR1 FGFR2
33 outer ear morphogenesis GO:0042473 9.49 FGFR1 TWIST1
34 lung-associated mesenchyme development GO:0060484 9.48 FGFR1 FGFR2
35 endochondral bone growth GO:0003416 9.46 FGFR2 FGFR3
36 orbitofrontal cortex development GO:0021769 9.32 FGFR1 FGFR2
37 ventricular zone neuroblast division GO:0021847 9.26 FGFR1 FGFR2
38 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0035607 9.16 FGFR1 FGFR2
39 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.13 FGFR1 FGFR2 FGFR3
40 positive regulation of phospholipase activity GO:0010518 8.8 FGFR1 FGFR2 FGFR3

Molecular functions related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.67 FGFR1 FGFR2 TWIST1
2 kinase activity GO:0016301 9.65 FGFR1 FGFR2 FGFR3
3 protein kinase activity GO:0004672 9.63 FGFR1 FGFR2 FGFR3
4 nucleotide binding GO:0000166 9.61 FGFR1 FGFR2 FGFR3
5 protein tyrosine kinase activity GO:0004713 9.58 FGFR1 FGFR2 FGFR3
6 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 FGFR1 FGFR2 FGFR3
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.5 FGFR1 FGFR2 FGFR3
8 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.43 FGFR1 FGFR2 FGFR3
9 1-phosphatidylinositol-3-kinase activity GO:0016303 9.33 FGFR1 FGFR2 FGFR3
10 fibroblast growth factor binding GO:0017134 9.13 FGFR1 FGFR2 FGFR3
11 fibroblast growth factor-activated receptor activity GO:0005007 8.8 FGFR1 FGFR2 FGFR3

Sources for Plagiocephaly

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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