MCID: PLG004
MIFTS: 40

Plagiocephaly malady

Summaries for Plagiocephaly

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64Wikipedia, 33MalaCards
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Wikipedia:64 Plagiocephaly, also known as flat head syndrome, is a condition characterized by an asymmetrical... more...

MalaCards: Plagiocephaly is related to synostosis and strabismus. An important gene associated with Plagiocephaly is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are TGF-Beta Pathway and p70S6K Signaling. The compounds SU4984 and Regorafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skeletal muscle, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Aliases & Classifications for Plagiocephaly

Sources:
43NIH Rare Diseases, 25ICD10
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Related Diseases for Plagiocephaly

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Plagiocephaly via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1synostosis30.8FGFR2, FGFR1, FGFR3, TWIST1
2strabismus30.3FGFR2, FGFR3
3crouzon syndrome29.8FGFR3, FGFR1, FGFR2
4muenke syndrome29.8FGFR2, FGFR1, FGFR3, TWIST1
5lambdoid synostosis10.3
6intellectual deficit, x-linked - plagiocephaly10.2
7congenital torticollis10.2
8plagiocephaly and x-linked mental retardation10.2
9craniosynostosis 310.2
10monoclonal gammopathy of uncertain significance10.0FGFR3
11pseudohypoparathyroidism10.0BGLAP
12osteochondroma10.0FGFR3
13cervical cancer10.0FGFR3
14sarcoma10.0TWIST1
15osteoglophonic dysplasia10.0FGFR1
16cleft lip10.0FGFR1
17myelodysplastic syndromes10.0FGFR1
18beare-stevenson cutis gyrata syndrome10.0FGFR2
19antley-bixler syndrome10.0FGFR2
20short stature10.0FGFR3, BGLAP
21osteosarcoma10.0BGLAP, TWIST1
22parathyroid adenoma10.0FGFR2
23giant cell tumor10.0FGFR3, BGLAP
24osteogenesis imperfecta10.0FGFR3, BGLAP
25achondroplasia10.0FGFR2, FGFR3
26syndactyly10.0FGFR2, FGFR3
27ladd syndrome10.0FGFR2, FGFR3
28retinoblastoma10.0FGFR2, FGFR3
29thanatophoric dysplasia10.0FGFR3, FGFR2
30thyroid cancer10.0BGLAP, FGFR2
31acanthosis nigricans10.0FGFR3, FGFR2
32infectious mononucleosis10.0FGFR2, FGFR1
33bladder carcinoma10.0FGFR3, FGFR2
34adenocarcinoma10.0FGFR1, FGFR2
35nasopharynx carcinoma10.0FGFR1, TWIST1
36fgfr-related craniosynostosis syndromes10.0FGFR2, FGFR1, FGFR3
37jackson-weiss syndrome10.0FGFR2, FGFR1, FGFR3
38acrocephalosyndactylia10.0FGFR3, FGFR1, FGFR2
39hypochondroplasia10.0FGFR2, FGFR1, FGFR3
40skeletal dysplasias10.0FGFR3, FGFR1, FGFR2
41chondrosarcoma10.0FGFR3, FGFR1, FGFR2
42developmental disabilities10.0FGFR3, FGFR1, FGFR2
43dwarfism10.0FGFR3, FGFR1, FGFR2
44pancreatic cancer10.0TWIST1, FGFR1, FGFR2
45transitional cell carcinoma10.0FGFR3, FGFR2
46cleft palate10.0FGFR2, FGFR1, TWIST1
47stomach cancer10.0TWIST1, FGFR1, FGFR2
48leukemia10.0FGFR3, FGFR1, FGFR2
49prostate cancer10.0BGLAP, FGFR2, FGFR1
50breast cancer10.0TWIST1, FGFR1, FGFR2

Graphical network of the top 20 diseases related to Plagiocephaly:



Diseases related to plagiocephaly

Clinical Features for Plagiocephaly

Drugs & Therapeutics for Plagiocephaly

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Plagiocephaly

Drug clinical trials:

Search ClinicalTrials for Plagiocephaly

Search NIH Clinical Center for Plagiocephaly

Search CenterWatch for Plagiocephaly

Genetic Tests for Plagiocephaly

Anatomical Context for Plagiocephaly

Sources:
33MalaCards
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MalaCards organs/tissues related to Plagiocephaly:

33
Brain, Heart, Skeletal muscle

Animal Models for Plagiocephaly or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Plagiocephaly:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.6FGFR3, FGFR1, FGFR2
2MP:00053828.1TWIST1, FGFR3, FGFR1, FGFR2
3MP:00053818.0FGFR2, FGFR1, FGFR3, TWIST1
4MP:00053907.8TWIST1, FGFR3, FGFR1, FGFR2

Publications for Plagiocephaly

Sources:
51PubMed
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Articles related to Plagiocephaly:

(show top 50)    (show all 290)
idTitleAuthorsYear
1
Helmet treatment of deformational plagiocephaly: the relationship between age at initiation and rate of correction. (23271554)
2013
2
Efficacy of passive helmet therapy for deformational plagiocephaly: report of 1050 cases. (24079783)
2013
3
Clinical course of asymmetric motor performance and deformational plagiocephaly in very preterm infants. (23706356)
2013
4
Early neurodevelopment in infants with deformational plagiocephaly. (23851774)
2013
5
Treatment of deformational plagiocephaly and torticollis using a weight distribution ring: a report of three cases. (23358241)
2013
6
A modified approach to surgical correction of anterior plagiocephaly. (23997494)
2012
7
Prevalence of positional plagiocephaly in teens born after the "Back to Sleep" campaign. (22241785)
2012
8
Cosmetic and cognitive outcomes of positional plagiocephaly treatment. (23043707)
2012
9
Anterior plagiocephaly: epidemiology, clinical findings,diagnosis, and classification. A review. (22872257)
2012
10
Increased incidence of metopic suture abnormalities in children with positional plagiocephaly. (21187772)
2011
11
Severe deformational plagiocephaly: long-term results of surgical treatment. (21187754)
2011
12
Deformational plagiocephaly: a look into the future. (21239916)
2011
13
Testing guidelines for child health care nurses to prevent nonsynostotic plagiocephaly: a Swedish pilot study. (22055374)
2011
14
Treatment of plagiocephaly with helmet molding therapy: do actual results mimic perception? (20500064)
2011
15
Divided parietal bone in plagiocephaly. (21239935)
2011
16
Outcome analysis of helmet therapy for positional plagiocephaly using a three-dimensional surface scanning laser. (19258908)
2009
17
Risk factors associated with deformational plagiocephaly. (19917588)
2009
18
Plagiocephaly and awareness, prevention and treatment. (18497228)
2008
19
Physiotherapy reduces the risk of deformational plagiocephaly in infants who have a preferred head position when lying supine. (19025511)
2008
20
Nonsurgical treatment of deformational plagiocephaly: a systematic review. (18678803)
2008
21
Long-term treatment effectiveness of molding helmet therapy in the correction of posterior deformational plagiocephaly: a five-year follow-up. (18452353)
2008
22
New World cranial deformation practices: historical implications for pathophysiology of cognitive impairment in deformational plagiocephaly. (18216707)
2008
23
Frontosphenoidal synostosis: a rare cause of unilateral anterior plagiocephaly. (17891404)
2007
24
Anterior fontanelle morphology in unilateral coronal synostosis: a clear clinical (nonradiographic) sign for the diagnosis of frontal plagiocephaly. (17440369)
2007
25
Nonsynostotic occipital plagiocephaly: factors impacting onset, treatment, and outcomes. (17440367)
2007
26
Palpatory diagnosis of plagiocephaly. (16648087)
2006
27
MDCT diagnosis of the child with posterior plagiocephaly. (16247160)
2005
28
Visual field defects in deformational posterior plagiocephaly. (15956949)
2005
29
Bipartite parietal bone: a rare cause of plagiocephaly. (15230767)
2004
30
Anthropometric study of synostotic frontal plagiocephaly: before and after fronto-orbital advancement with correction of nasal angulation. (12960853)
2003
31
Multiple-birth infants at higher risk for development of deformational plagiocephaly: II. is one twin at greater risk? (11773537)
2002
32
The treatment of the positional plagiocephaly with a new thermoplastic orthotic device. (12172942)
2002
33
Re: Helmet versus nonhelmet treatment in nonsynostotic positional posterior plagiocephaly. (11314198)
2001
34
Coincident metopic synostosis and deformational plagiocephaly. (10726498)
1999
35
Pediatric management problems. Plagiocephaly. (9555451)
1998
36
Synostotic plagiocephaly causing pseudoparalysis of the superior oblique and ocular torticollis: report of a case with unique sensory findings. (9852441)
1998
37
Plagiocephaly--what is the cause? (9648309)
1998
38
Operative treatment of the anterior synostotic plagiocephaly: analysis of 45 cases. (9808253)
1998
39
Etiology of positional plagiocephaly in triplets and treatment using a dynamic orthotic cranioplasty device. Report of three cases. (15096018)
1997
40
Nonsurgical, nonorthotic treatment of occipital plagiocephaly: what is the natural history of the misshapen neonatal head? (15096019)
1997
41
Lambdoid stenosis (posterior plagiocephaly) and craniofacial asymmetry: long-term outcomes. (9118137)
1996
42
Quantitative analysis of cerebrospinal fluid spaces in children with occipital plagiocephaly. (8751628)
1996
43
The differential diagnosis of posterior plagiocephaly: true lambdoid synostosis versus positional molding. (8823012)
1996
44
Plagiocephaly--new classification and clinical study of a series of 100 patients. (8839328)
1995
45
Frontal plagiocephaly secondary to synostosis of the frontosphenoidal suture. Case report. (7674026)
1995
46
The operative treatment of isolated craniofacial dysostosis (plagiocephaly): a comparison of the unilateral and bilateral techniques. (2326350)
1990
47
Craniofacial growth in plagiocephaly and Crouzon syndrome. (7347002)
1981
48
Plagiocephaly and torticollis: etiology, natural history, and helmet treatment. (7452415)
1981
49
Plagiocephaly. (281247)
1978
50
PLAGIOCEPHALY AND VOMITING. (14061096)
1963

Genetic Variations for Plagiocephaly

Expression for genes affiliated with Plagiocephaly

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plagiocephaly

Search GEO for disease gene expression data for Plagiocephaly.

Pathways for genes affiliated with Plagiocephaly

Sources:
52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 54Reactome, 53R&D Systems, 4Cell Signaling Technology, 50PharmGKB, 12EMD Millipore, 60Tocris Bioscience
See all sources

Pathways related to Plagiocephaly according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7FGFR2
2
Hide members
9.7FGFR2
39.4TWIST1, BGLAP
49.4FGFR3, FGFR1
5
Hide members
9.0FGFR1, FGFR2
6
Hide members
8.6FGFR3, FGFR1, FGFR2
7
Hide members
8.6FGFR2, FGFR1, FGFR3
88.6FGFR3, FGFR1, FGFR2
98.6FGFR2, FGFR1, FGFR3
10
Hide members
8.6FGFR2, FGFR1, FGFR3
11
Hide members
8.6FGFR2, FGFR1, FGFR3
128.6FGFR3, FGFR1, FGFR2
13
Hide members
8.6FGFR2, FGFR1, FGFR3
14
Hide members
8.6FGFR2, FGFR1, FGFR3
15
Hide members
8.6FGFR2, FGFR1, FGFR3
16
Hide members
8.6FGFR2, FGFR1, FGFR3
17
Hide members
8.6FGFR2, FGFR1, FGFR3
18
Hide members
8.6FGFR3, FGFR1, FGFR2
19
Hide members
8.6FGFR3, FGFR1, FGFR2
20
Hide members
8.6FGFR3, FGFR1, FGFR2
21
Hide members
8.6FGFR3, FGFR1, FGFR2
228.6FGFR2, FGFR1, FGFR3
238.6FGFR3, FGFR1, FGFR2
24
Hide members
8.6FGFR2, FGFR1, FGFR3
258.6FGFR3, FGFR1, FGFR2
26
Hide members
8.6FGFR3, FGFR1, FGFR2
27
Hide members
8.6FGFR2, FGFR1, FGFR3
288.6FGFR2, FGFR1, FGFR3
29
Hide members
8.6FGFR3, FGFR1, FGFR2
308.6FGFR3, FGFR1, FGFR2
31
Development FGF-family signaling
Hide members
8.6FGFR3, FGFR1, FGFR2
32
Hide members
8.6FGFR2, FGFR1, FGFR3
33
Hide members
8.6FGFR3, FGFR1, FGFR2
34
Hide members
8.6FGFR2, FGFR1, FGFR3
35
Hide members
8.6FGFR3, FGFR1, FGFR2
36
Hide members
8.6FGFR3, FGFR1, FGFR2
37
Hide members
8.6FGFR2, FGFR1, FGFR3
38
Hide members
8.6FGFR3, FGFR1, FGFR2
39
Hide members
8.6FGFR2, FGFR1, FGFR3
408.5BGLAP, FGFR2, FGFR1
418.1TWIST1, FGFR3, FGFR1, FGFR2

Compounds for genes affiliated with Plagiocephaly

Sources:
11DrugBank, 45Novoseek, 50PharmGKB, 60Tocris Bioscience, 24HMDB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Plagiocephaly according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1SU4984119.4FGFR1, FGFR2
2Regorafenib119.3FGFR2, FGFR1
3thalidomide45 50 60 1112.3FGFR3, FGFR2
4chondroitin sulfate45 2410.0FGFR1, FGFR2
5suramin45 29 1111.0FGFR1, FGFR2
6su 5402608.9FGFR3, FGFR2, FGFR1
7pd 161570608.9FGFR2, FGFR1, FGFR3
8fiin 1 hydrochloride608.9FGFR2, FGFR1, FGFR3
9su5402458.9FGFR2, FGFR1, FGFR3
10paraffin458.9FGFR3, FGFR2, BGLAP
11pd 17307445 609.9FGFR3, FGFR1, FGFR2
12palifermin45 119.9FGFR3, FGFR1, FGFR2
13Ponatinib 118.9FGFR2, FGFR1, FGFR3
14phenylalanine458.9FGFR2, FGFR1, FGFR3
15phosphotyrosine458.9FGFR3, FGFR1, FGFR2
16azathioprine45 50 2 1111.8FGFR2, BGLAP
17lysine458.8FGFR2, FGFR1, FGFR3
18paclitaxel45 50 1110.8TWIST1, FGFR1, FGFR2
19heparin45 29 11 2411.7BGLAP, FGFR2, FGFR1
20h2o2458.7FGFR1, FGFR2, BGLAP
21testosterone45 60 11 2411.6BGLAP, FGFR2, FGFR1
22oligonucleotide458.5FGFR2, FGFR1, FGFR3
23vegf458.4FGFR3, FGFR1, FGFR2, BGLAP
24cysteine458.3FGFR3, FGFR1, FGFR2, BGLAP
25serine458.3FGFR3, FGFR1, FGFR2, BGLAP
26tyrosine458.2FGFR2, FGFR1, FGFR3, TWIST1

GO Terms for genes affiliated with Plagiocephaly

Sources:
16Gene Ontology
See all sources

Cellular components related to Plagiocephaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:0160238.3FGFR3, FGFR1, FGFR2
2extracellular regionGO:0055768.1FGFR3, FGFR1, FGFR2, BGLAP

Biological processes related to Plagiocephaly according to GeneCards/GeneDecks:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:0900809.8FGFR3, FGFR1
2regulation of bone mineralizationGO:0305009.8TWIST1, BGLAP
3outer ear morphogenesisGO:0424739.7FGFR1, TWIST1
4chondrocyte differentiationGO:0020629.7FGFR1, FGFR3
5negative regulation of mitosisGO:0458399.6FGFR3, FGFR2
6lens fiber cell developmentGO:0703079.6FGFR2, FGFR3
7osteoblast differentiationGO:0016499.5BGLAP, TWIST1
8bone morphogenesisGO:0603499.5FGFR3, FGFR2
9fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:0356079.5FGFR1, FGFR2
10ventricular zone neuroblast divisionGO:0218479.5FGFR2, FGFR1
11embryonic cranial skeleton morphogenesisGO:0487019.4FGFR2, TWIST1
12mesenchymal cell differentiationGO:0487629.4FGFR1, FGFR2
13bone developmentGO:0603489.4FGFR2, BGLAP
14lung-associated mesenchyme developmentGO:0604849.4FGFR1, FGFR2
15odontogenesisGO:0424769.4FGFR2, BGLAP
16branching involved in salivary gland morphogenesisGO:0604459.4FGFR1, FGFR2
17MAPK cascadeGO:0001659.4FGFR3, FGFR1
18positive regulation of cardiac muscle cell proliferationGO:0600459.4FGFR1, FGFR2
19bone mineralizationGO:0302829.4FGFR2, BGLAP
20skeletal system morphogenesisGO:0487059.4FGFR2, FGFR1
21positive regulation of canonical Wnt receptor signaling pathwayGO:0902639.3FGFR3, FGFR2
22positive regulation of cell cycleGO:0457879.3FGFR2, FGFR1
23neuron migrationGO:0017649.3TWIST1, FGFR1
24midbrain developmentGO:0309019.3FGFR2, FGFR1
25skeletal system developmentGO:0015019.3FGFR3, FGFR1, BGLAP
26positive regulation of mesenchymal cell proliferationGO:0020539.3FGFR1, FGFR2
27ureteric bud developmentGO:0016579.2FGFR2, FGFR1
28inner ear morphogenesisGO:0424729.1FGFR1, FGFR2
29positive regulation of phospholipase activityGO:0105189.0FGFR3, FGFR1, FGFR2
30peptidyl-tyrosine phosphorylationGO:0181089.0FGFR2, FGFR1, FGFR3
31positive regulation of MAPK cascadeGO:0434109.0FGFR3, FGFR1, FGFR2
32phosphatidylinositol-mediated signalingGO:0480159.0FGFR2, FGFR1, FGFR3
33insulin receptor signaling pathwayGO:0082869.0FGFR2, FGFR1, FGFR3
34protein autophosphorylationGO:0467779.0FGFR3, FGFR1, FGFR2
35fibroblast growth factor receptor signaling pathwayGO:0085439.0FGFR2, FGFR1, FGFR3
36Fc-epsilon receptor signaling pathwayGO:0380958.9FGFR3, FGFR1, FGFR2
37epidermal growth factor receptor signaling pathwayGO:0071738.9FGFR2, FGFR1, FGFR3
38neurotrophin TRK receptor signaling pathwayGO:0480118.9FGFR2, FGFR1, FGFR3
39positive regulation of ERK1 and ERK2 cascadeGO:0703748.9FGFR3, FGFR2
40in utero embryonic developmentGO:0017018.9FGFR2, FGFR1, TWIST1
41positive regulation of cell proliferationGO:0082848.8FGFR3, FGFR1, FGFR2
42innate immune responseGO:0450878.5FGFR2, FGFR1, FGFR3
43negative regulation of transcription from RNA polymerase II promoterGO:0001228.5FGFR2, FGFR1, FGFR3, TWIST1

Molecular functions related to Plagiocephaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:0050078.6FGFR3, FGFR1, FGFR2
2protein homodimerization activityGO:0428038.5TWIST1, FGFR1, FGFR2
3fibroblast growth factor bindingGO:0171348.5FGFR3, FGFR1, FGFR2
4protein tyrosine kinase activityGO:0047138.3FGFR2, FGFR1, FGFR3

Products for genes affiliated with Plagiocephaly

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Plagiocephaly

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet