Aliases & Classifications for Plagiocephaly

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Summaries for Plagiocephaly

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Wikipedia:64 Plagiocephaly, also known as flat head syndrome, is a condition characterized by an asymmetrical... more...

MalaCards based summary: Plagiocephaly is related to strabismus and synostosis. An important gene associated with Plagiocephaly is TWIST1 (twist family bHLH transcription factor 1), and among its related pathways are Notch-mediated HES/HEY network and Endochondral Ossification. The compounds thalidomide and azathioprine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and eye, and related mouse phenotypes are renal/urinary system and hearing/vestibular/ear.

Related Diseases for Plagiocephaly

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Diseases related to Plagiocephaly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1strabismus30.7FGFR3, FGFR2
2synostosis30.4TWIST1, FGFR2, FGFR1, FGFR3
3craniosynostosis30.1TWIST1, FGFR2, FGFR1, FGFR3
4muenke syndrome29.7TWIST1, FGFR2, FGFR1, FGFR3
5crouzon syndrome29.7FGFR2, FGFR1, FGFR3
6saethre-chotzen syndrome29.0FGFR3, FGFR1, FGFR2, TWIST1, BGLAP
7lambdoid synostosis10.5
8beare-stevenson cutis gyrata syndrome10.4FGFR2
9antley-bixler syndrome10.4FGFR2
10osteochondroma10.4FGFR3
11isolated plagiocephaly10.4
12osteoglophonic dysplasia10.3FGFR1
13hyde forster mccarthy berry syndrome10.3
14plagiocephaly and x-linked mental retardation10.2
15achondroplasia10.2FGFR2, FGFR3
16ladd syndrome10.2FGFR3, FGFR2
17thanatophoric dysplasia, type i10.2FGFR3, FGFR2
18acanthosis nigricans10.2FGFR2, FGFR3
19syndactyly10.1FGFR3, FGFR2
20giant cell tumor10.1BGLAP, FGFR3
21osteogenesis imperfecta10.1FGFR3, BGLAP
22transitional cell carcinoma10.1FGFR3, FGFR2
23aicardi syndrome10.1
24fibrochondrogenesis10.1
25schimmelpenning-feuerstein-mims syndrome, somatic mosaic10.1
26craniofrontonasal dysplasia10.1
27aicardi-goutieres syndrome10.1
2849, xxxxx10.1
29anophthalmia megalocornea cardiopathy skeletal anomalies10.1
30chromosome 20p duplication10.1
31chromosome 6q25 microdeletion syndrome10.1
32faciocardiorenal syndrome10.1
33fetal brain disruption sequence10.1
34fine-lubinsky syndrome10.1
35genoa syndrome10.1
36malignant hyperthermia arthrogryposis torticollis10.1
37microgastria limb reduction defect10.1
38neurofaciodigitorenal syndrome10.1
39polydactyly postaxial dental and vertebral10.1
40rommen mueller sybert syndrome10.1
41splenogonadal fusion limb defects micrognatia10.1
42summitt syndrome10.1
43torticollis keloids cryptorchidism renal dysplasia10.1
44intellectual disability - cataracts - calcified pinnae - myopathy10.1
45auriculoocular anomalies - cleft lip10.1
46bresek syndrome10.1
47severe intellectual disability - epilepsy - anal anomalies - distal phalangeal hypoplasia10.1
48pfeiffer syndrome10.1FGFR2, FGFR1
49bladder cancer, somatic10.1FGFR3, FGFR2
50prostatic hypertrophy10.0FGFR2, FGFR1

Graphical network of the top 20 diseases related to Plagiocephaly:



Diseases related to plagiocephaly

Symptoms for Plagiocephaly

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Drugs & Therapeutics for Plagiocephaly

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Drug clinical trials:

Search ClinicalTrials for Plagiocephaly

Search NIH Clinical Center for Plagiocephaly

Genetic Tests for Plagiocephaly

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Anatomical Context for Plagiocephaly

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MalaCards organs/tissues related to Plagiocephaly:

31
Brain, Bone, Eye, Heart, Testes

Animal Models for Plagiocephaly or affiliated genes

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MGI Mouse Phenotypes related to Plagiocephaly:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.4FGFR3, FGFR2
2MP:00053778.7FGFR2, FGFR1, FGFR3
3MP:00053718.4FGFR3, FGFR1, FGFR2, TWIST1
4MP:00053828.4TWIST1, FGFR2, FGFR1, FGFR3
5MP:00053818.3TWIST1, FGFR2, FGFR1, FGFR3
6MP:00053908.3FGFR3, FGFR1, FGFR2, TWIST1
7MP:00053868.2FGFR3, FGFR1, FGFR2, TWIST1
8MP:00053848.2TWIST1, FGFR2, FGFR1, FGFR3
9MP:00036318.1TWIST1, FGFR2, FGFR1, FGFR3
10MP:00053787.9FGFR3, FGFR1, FGFR2, TWIST1

Publications for Plagiocephaly

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Articles related to Plagiocephaly:

(show top 50)    (show all 310)
idTitleAuthorsYear
1
Preventing deformational plagiocephaly through parent guidance: a randomized, controlled trial. (25823758)
2015
2
Argenta Clinical Classification of Deformational Plagiocephaly. (25901672)
2015
3
Isolated frontosphenoidal synostosis: a rare cause of synostotic frontal plagiocephaly. (24606403)
2014
4
Congenital muscular torticollis and positional plagiocephaly. (24488831)
2014
5
Management of positional plagiocephaly--helmet or no helmet? (24864022)
2014
6
A complicated case of plagiocephaly followed by delayed craniosynostosis. (23595804)
2013
7
Orthotic (helmet) therapy in the treatment of plagiocephaly. (24079781)
2013
8
A modified approach to surgical correction of anterior plagiocephaly. (23997494)
2012
9
Prevalence of positional plagiocephaly in teens born after the "Back to Sleep" campaign. (22241785)
2012
10
Craniosynostosis and deformational plagiocephaly: when and how to intervene. (22866500)
2012
11
Head orthesis therapy in infants with unilateral positional plagiocephaly: an interdisciplinary approach to broadening the range of orthodontic treatment. (22388713)
2012
12
Increased incidence of metopic suture abnormalities in children with positional plagiocephaly. (21187772)
2011
13
Investigation into an increase in plagiocephaly in Texas from 1999 to 2007. (21464373)
2011
14
Exploring the impact of osteopathic treatment on cranial asymmetries associated with nonsynostotic plagiocephaly in infants. (21982132)
2011
15
Severe deformational plagiocephaly: long-term results of surgical treatment. (21187754)
2011
16
Development in toddlers with and without deformational plagiocephaly. (21727278)
2011
17
Prevalence, risk factors, and natural history of positional plagiocephaly: a systematic review. (18754894)
2008
18
Plagiocephaly, brachycephaly and cranial orthotic devices: misshapen heads and helmets. (18719162)
2008
19
Plagiocephaly and awareness, prevention and treatment. (18497228)
2008
20
Comparison of a modifiable cranial cup versus repositioning and cervical stretching for the early correction of deformational posterior plagiocephaly. (18317143)
2008
21
Frontosphenoidal synostosis: a rare cause of unilateral anterior plagiocephaly. (17891404)
2007
22
Diagnostic value of skull x rays in infants with plagiocephaly. (17119094)
2006
23
Variable co-diagnosis of plagiocephaly and torticollis in Texas health care facilities. (16633168)
2006
24
Comparison of infant head shape changes in deformational plagiocephaly following treatment with a cranial remolding orthosis using a noninvasive laser shape digitizer. (17119410)
2006
25
Cranial distraction for plagiocephaly: quantitative morphologic analyses of cranium using three-dimensional computed tomography and a life-size model. (16077318)
2005
26
Conservative interventions for positional plagiocephaly: a systematic review. (16108460)
2005
27
Molding helmet therapy in the treatment of brachycephaly and plagiocephaly. (14704577)
2004
28
Plagiocephaly and brachycephaly in the first two years of life: a prospective cohort study. (15466093)
2004
29
Objective outcome analysis of soft shell helmet therapy in the treatment of deformational plagiocephaly. (15213546)
2004
30
Bipartite parietal bone: a rare cause of plagiocephaly. (15230767)
2004
31
Plagiocephaly: morphometry of skull base asymmetry. (14504821)
2003
32
Plagiocephaly--more questions than answers. (14581963)
2003
33
Determinants of nonsynostotic plagiocephaly: a case-control study. (14523218)
2003
34
Deformational posterior plagiocephaly: diagnosis and treatment. (12401104)
2002
35
Study of asymmetries of the cranial vault in plagiocephaly. (12218795)
2002
36
Ocular plagiocephaly: Author's reply (11097572)
2000
37
Update on craniofacial surgery: the differential diagnosis of lambdoid synostosis/posterior plagiocephaly. (11197708)
2000
38
Sternocleidomastoid imbalance versus congenital muscular torticollis: their relationship to positional plagiocephaly. (10342615)
1999
39
Positional plagiocephaly: a community approach to prevention and treatment. (10602685)
1999
40
Etiology of positional plagiocephaly in triplets and treatment using a dynamic orthotic cranioplasty device. Report of three cases. (15096018)
1997
41
Occipital plagiocephaly: an epidemic of craniosynostosis? (9314744)
1997
42
Diagnosis and management of posterior plagiocephaly. (9024443)
1997
43
A novel mutation (a886g) in exon 5 of FGFR2 in members of a family with Crouzon phenotype and plagiocephaly. (9152842)
1997
44
A prospective study of the relationship between strabismus and head posture in patients with frontal plagiocephaly. (8618990)
1996
45
Clinical presentation and management of 100 infants with occipital plagiocephaly. (9055327)
1996
46
Occipital plagiocephaly: deformation or lambdoid synostosis? II. A unifying theory regarding pathogenesis. (8841076)
1996
47
Refractive error and ocular motility in plagiocephaly. (7923229)
1994
48
Ocular manifestations of deformational frontal plagiocephaly. (8501624)
1993
49
Orbital expansion in plagiocephaly. (3345403)
1988
50
Helmet treatment for plagiocephaly and congenital muscular torticollis. (758420)
1979

Variations for Plagiocephaly

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Expression for genes affiliated with Plagiocephaly

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Search GEO for disease gene expression data for Plagiocephaly.

Pathways for genes affiliated with Plagiocephaly

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Pathways related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4BGLAP, TWIST1
29.1FGFR3, FGFR1
3
Show member pathways
9.1FGFR3, FGFR1
4
Show member pathways
8.6FGFR1, FGFR2, FGFR3
5
Show member pathways
8.6FGFR3, FGFR1, FGFR2
6
Show member pathways
8.6FGFR2, FGFR1, FGFR3
7
Show member pathways
8.6FGFR1, FGFR3, FGFR2
88.6FGFR3, FGFR1, FGFR2
9
Show member pathways
8.6FGFR2, FGFR3, FGFR1
108.6FGFR1, FGFR2, FGFR3
11
Show member pathways
8.6FGFR3, FGFR2, FGFR1
12
Show member pathways
8.6FGFR1, FGFR2, FGFR3
13
Show member pathways
8.6FGFR2, FGFR1, FGFR3
14
Show member pathways
8.6FGFR1, FGFR3, FGFR2
15
Show member pathways
8.6FGFR2, FGFR1, FGFR3
168.6FGFR3, FGFR1, FGFR2
17
Show member pathways
8.6FGFR1, FGFR3, FGFR2
18
Show member pathways
8.6FGFR1, FGFR2, FGFR3
19
Show member pathways
8.6FGFR3, FGFR1, FGFR2
20
Show member pathways
8.6FGFR1, FGFR3, FGFR2
21
Show member pathways
8.6FGFR3, FGFR1, FGFR2
22
Show member pathways
8.6FGFR3, FGFR1, FGFR2
23
Show member pathways
8.6FGFR2, FGFR3, FGFR1
248.6FGFR3, FGFR1, FGFR2
258.6FGFR1, FGFR3, FGFR2
268.6FGFR1, FGFR2, FGFR3
27
Show member pathways
8.6FGFR3, FGFR1, FGFR2
28
Show member pathways
8.6FGFR2, FGFR1, FGFR3
29
Show member pathways
8.6FGFR1, FGFR3, FGFR2
308.6FGFR3, FGFR1, FGFR2
31
Show member pathways
8.6FGFR2, FGFR1, FGFR3
32
Show member pathways
8.6FGFR1, FGFR3, FGFR2
33
Show member pathways
8.6FGFR3, FGFR2, FGFR1
34
Show member pathways
8.6FGFR3, FGFR1, FGFR2
35
Show member pathways
8.6FGFR3, FGFR2, FGFR1
36
Show member pathways
8.6FGFR2, FGFR1, FGFR3
37
Show member pathways
MAPK signaling pathway36
8.6FGFR2, FGFR3, FGFR1
38
Show member pathways
8.6FGFR2, FGFR1, FGFR3
39
Show member pathways
8.6FGFR3, FGFR1, FGFR2
40
Show member pathways
8.6FGFR1, FGFR2, FGFR3
41
Show member pathways
8.6FGFR2, FGFR3, FGFR1
42
Show member pathways
Signaling Pathways in Glioblastoma36
8.6FGFR1, FGFR2, FGFR3
438.5FGFR1, FGFR2, BGLAP
448.2FGFR3, FGFR1, FGFR2, TWIST1

Compounds for genes affiliated with Plagiocephaly

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Compounds related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 36)
idCompoundScoreTop Affiliating Genes
1thalidomide44 50 60 1112.7FGFR3, FGFR2
2azathioprine44 1 50 1112.5FGFR2, BGLAP
3sulfate44 2410.5FGFR2, FGFR3
4pazopanib50 1110.5FGFR3, FGFR1
5regorafenib50 1110.5FGFR2, FGFR1
6chondroitin sulfate44 2410.4FGFR1, FGFR2
7suramin44 28 1111.3FGFR2, FGFR1
8paraffin449.2FGFR3, BGLAP, FGFR2
9bromodeoxyuridine449.1FGFR2, FGFR1
10heparan sulfate44 2410.1FGFR1, FGFR2
11arginine449.0FGFR3, FGFR2, BGLAP
12paclitaxel44 50 1111.0TWIST1, FGFR1, FGFR2
13pd 161570609.0FGFR3, FGFR1, FGFR2
14su 5402609.0FGFR2, FGFR1, FGFR3
15fiin 1 hydrochloride609.0FGFR3, FGFR1, FGFR2
16su5402449.0FGFR3, FGFR1, FGFR2
17pd 17307444 6010.0FGFR1, FGFR2, FGFR3
18palifermin44 1110.0FGFR2, FGFR3, FGFR1
19ponatinib50 1110.0FGFR1, FGFR3, FGFR2
20phenylalanine449.0FGFR2, FGFR1, FGFR3
21phosphotyrosine449.0FGFR1, FGFR3, FGFR2
22lysine448.9FGFR3, FGFR1, FGFR2
23oligonucleotide448.9FGFR1, FGFR3, FGFR2
24imatinib44 50 1110.8FGFR3, FGFR1
25heparin44 28 24 1111.8FGFR2, BGLAP, FGFR1
26h2o2448.8FGFR1, BGLAP, FGFR2
27testosterone44 60 24 1111.8FGFR2, FGFR1, BGLAP
28threonine448.8FGFR1, FGFR2, FGFR3
29glutamate448.7FGFR2, FGFR1, FGFR3
30tyrosine448.5FGFR2, TWIST1, FGFR1, FGFR3
31estrogen448.4BGLAP, TWIST1, FGFR2, FGFR1
32retinoic acid44 249.4FGFR1, BGLAP, FGFR2
33vegf448.4FGFR2, FGFR3, BGLAP, FGFR1
34cysteine448.4BGLAP, FGFR2, FGFR1, FGFR3
35serine448.3FGFR3, BGLAP, FGFR1, FGFR2
36calcium44 50 24 1111.3BGLAP, FGFR2, FGFR1, FGFR3

GO Terms for genes affiliated with Plagiocephaly

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Cellular components related to Plagiocephaly according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.6FGFR3, FGFR1, FGFR2
2cytoplasmic membrane-bounded vesicleGO:00160238.5FGFR3, FGFR1, FGFR2
3extracellular regionGO:00055767.7BGLAP, FGFR2, FGFR1, FGFR3

Biological processes related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1lens fiber cell developmentGO:00703079.8FGFR2, FGFR3
2embryonic cranial skeleton morphogenesisGO:00487019.8TWIST1, FGFR2
3negative regulation of mitosisGO:00458399.8FGFR3, FGFR2
4bone morphogenesisGO:00603499.8FGFR3, FGFR2
5regulation of bone mineralizationGO:00305009.8TWIST1, BGLAP
6bone mineralizationGO:00302829.6FGFR2, BGLAP
7negative regulation of epithelial cell proliferationGO:00506809.6FGFR3, FGFR2
8bone developmentGO:00603489.6BGLAP, FGFR2
9cellular response to growth factor stimulusGO:00713639.6TWIST1, BGLAP
10outer ear morphogenesisGO:00424739.6TWIST1, FGFR1
11positive regulation of canonical Wnt signaling pathwayGO:00902639.6FGFR3, FGFR2
12osteoblast differentiationGO:00016499.6BGLAP, TWIST1
13fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:00356079.6FGFR1, FGFR2
14ventricular zone neuroblast divisionGO:00218479.6FGFR2, FGFR1
15positive regulation of epithelial cell proliferationGO:00506799.6FGFR2, TWIST1
16positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:00900809.6FGFR3, FGFR1
17mesenchymal cell differentiationGO:00487629.5FGFR1, FGFR2
18lung-associated mesenchyme developmentGO:00604849.5FGFR1, FGFR2
19branching involved in salivary gland morphogenesisGO:00604459.5FGFR1, FGFR2
20positive regulation of cardiac muscle cell proliferationGO:00600459.5FGFR1, FGFR2
21skeletal system morphogenesisGO:00487059.5FGFR1, FGFR2
22positive regulation of cell cycleGO:00457879.5FGFR2, FGFR1
23midbrain developmentGO:00309019.4FGFR2, FGFR1
24positive regulation of mesenchymal cell proliferationGO:00020539.4FGFR2, FGFR1
25chondrocyte differentiationGO:00020629.4FGFR1, FGFR3
26ureteric bud developmentGO:00016579.4FGFR2, FGFR1
27odontogenesisGO:00424769.3FGFR2, TWIST1, BGLAP
28inner ear morphogenesisGO:00424729.2FGFR2, FGFR1
29neuron migrationGO:00017649.2FGFR1, TWIST1
30MAPK cascadeGO:00001659.1FGFR3, FGFR1
31positive regulation of ERK1 and ERK2 cascadeGO:00703749.1FGFR2, FGFR3
32positive regulation of phospholipase activityGO:00105189.1FGFR3, FGFR1, FGFR2
33positive regulation of MAPK cascadeGO:00434109.0FGFR2, FGFR3, FGFR1
34in utero embryonic developmentGO:00017019.0FGFR2, TWIST1, FGFR1
35peptidyl-tyrosine phosphorylationGO:00181089.0FGFR2, FGFR1, FGFR3
36phosphatidylinositol-mediated signalingGO:00480159.0FGFR1, FGFR3, FGFR2
37insulin receptor signaling pathwayGO:00082869.0FGFR2, FGFR1, FGFR3
38protein autophosphorylationGO:00467779.0FGFR3, FGFR1, FGFR2
39fibroblast growth factor receptor signaling pathwayGO:00085439.0FGFR1, FGFR3, FGFR2
40Fc-epsilon receptor signaling pathwayGO:00380959.0FGFR2, FGFR1, FGFR3
41epidermal growth factor receptor signaling pathwayGO:00071739.0FGFR2, FGFR3, FGFR1
42neurotrophin TRK receptor signaling pathwayGO:00480119.0FGFR2, FGFR3, FGFR1
43skeletal system developmentGO:00015018.9FGFR1, FGFR3, BGLAP
44positive regulation of cell proliferationGO:00082848.8FGFR3, FGFR2, FGFR1
45negative regulation of transcription from RNA polymerase II promoterGO:00001228.6FGFR2, FGFR1, FGFR3, TWIST1
46innate immune responseGO:00450878.5FGFR2, FGFR3, FGFR1

Molecular functions related to Plagiocephaly according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.1FGFR1, FGFR2
2fibroblast growth factor-activated receptor activityGO:00050078.7FGFR3, FGFR1, FGFR2
3fibroblast growth factor bindingGO:00171348.6FGFR3, FGFR1, FGFR2
4protein tyrosine kinase activityGO:00047138.5FGFR2, FGFR1, FGFR3
5protein homodimerization activityGO:00428038.4FGFR1, FGFR2, TWIST1

Sources for Plagiocephaly

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet