Aliases & Classifications for Plagiocephaly

Summaries for Plagiocephaly

MalaCards based summary : Plagiocephaly is related to isolated plagiocephaly and plagiocephaly and x-linked mental retardation. An important gene associated with Plagiocephaly is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Phospholipase-C Pathway. The drug Salicylic acid has been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotypes are Decreased human cytomegalovirus (HCMV) strain AD169 replication and Decreased substrate adherent cell growth

Wikipedia : 72 Plagiocephaly, also known as flat head syndrome, is a condition characterized by an asymmetrical... more...

Related Diseases for Plagiocephaly

Diseases related to Plagiocephaly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Related Disease Score Top Affiliating Genes
1 isolated plagiocephaly 12.0
2 plagiocephaly and x-linked mental retardation 11.8
3 hyde forster mccarthy berry syndrome 10.9
4 mental retardation, x-linked, with craniofacial dysmorphism 10.8
5 muenke syndrome 10.8
6 faciocardiorenal syndrome 10.8
7 brachycephaly, deafness, cataract, microstomia, and mental retardation 10.8
8 iqsec2 10.8
9 synostosis 10.4
10 craniosynostosis 10.2
11 lambdoid synostosis 10.2
12 gastric linitis plastica 10.2 FGFR3 TWIST1
13 acute opioid poisoning 10.2 FGFR3 TWIST1
14 ocular hypotension 10.0 FGFR2 FGFR3
15 strabismus 10.0
16 apert syndrome 10.0 FGFR2 FGFR3
17 esotropia 10.0 FGFR2 FGFR3
18 crouzon syndrome with acanthosis nigricans 10.0 FGFR2 FGFR3
19 mucinoses 10.0 FGFR2 FGFR3
20 simosa craniofacial syndrome 9.9 FGFR2 FGFR3
21 cervicitis 9.9
22 slc6a4-related altered drug metabolism 9.9 FGFR2 FGFR3
23 central nervous system chondroma 9.9 FGFR2 FGFR3
24 syringobulbia 9.8 FGFR1 FGFR3
25 y-linked disease 9.8 FGFR2 FGFR3
26 osteopetrosis and infantile neuroaxonal dystrophy 9.8 FGFR1 FGFR3
27 phkg2-related phosphorylase kinase deficiency 9.7 FGFR1 FGFR2
28 uterus bicornis bicollis with partial vaginal septum and unilateral hematocolpos with ipsilateral renal agenesis 9.7 FGFR1 FGFR2
29 juvenile astrocytoma 9.7 FGFR1 FGFR3
30 paget's disease of bone 9.7 FGFR2 FGFR3
31 ichthyosis lamellar 1 9.7 FGFR2 FGFR3
32 sudden infant death syndrome 9.7
33 crouzon syndrome 9.7
34 otitis media 9.7
35 hemifacial microsomia 9.7
36 hemangioma 9.7
37 scoliosis 9.7
38 astigmatism 9.7
39 dysostosis 9.7
40 refractive error 9.7
41 weill-marchesani syndrome 9.7 FGFR1 FGFR2
42 pancreatic serous cystic neoplasm 9.5 FGFR1 FGFR2
43 grade iii astrocytoma 9.3 FGFR1 FGFR3 TWIST1
44 myasthenic syndrome, congenital, 2a, slow-channel 9.3 FGFR1 FGFR2
45 trigonocephaly 1 9.3 FGFR1 FGFR2 FGFR3
46 hypogonadotropic hypogonadism 2 with or without anosmia 9.3 FGFR1 FGFR2 FGFR3
47 thanatophoric dysplasia, type i 9.3 FGFR1 FGFR2 FGFR3
48 beare-stevenson cutis gyrata syndrome 9.3 FGFR1 FGFR2 FGFR3
49 thanatophoric dysplasia, type ii 9.3 FGFR1 FGFR2 FGFR3
50 hypochondroplasia 9.2 FGFR1 FGFR2 FGFR3

Graphical network of the top 20 diseases related to Plagiocephaly:



Diseases related to Plagiocephaly

Symptoms & Phenotypes for Plagiocephaly

GenomeRNAi Phenotypes related to Plagiocephaly according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.13 FGFR1 FGFR2 FGFR3
2 Decreased substrate adherent cell growth GR00193-A-2 8.8 FGFR2
3 Decreased substrate adherent cell growth GR00193-A-3 8.8 FGFR2 FGFR3

MGI Mouse Phenotypes related to Plagiocephaly:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.62 FGFR1 FGFR2 FGFR3 TWIST1
2 digestive/alimentary MP:0005381 9.56 FGFR1 FGFR2 FGFR3 TWIST1
3 hearing/vestibular/ear MP:0005377 9.33 FGFR1 FGFR2 FGFR3
4 limbs/digits/tail MP:0005371 9.26 FGFR1 FGFR2 FGFR3 TWIST1
5 skeleton MP:0005390 8.92 FGFR1 FGFR2 FGFR3 TWIST1

Drugs & Therapeutics for Plagiocephaly

Drugs for Plagiocephaly (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salicylic acid Approved, Vet_approved 69-72-7 338

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Postural Assessment in Plagiocephaly Completed NCT01989286
2 Investigating the Effectiveness of Mobilization on Congenital Muscular Torticollis and Deformational Plagiocephaly Recruiting NCT02403011
3 Premie Pouch to Manage Deformational Plagiocephaly in Very Low Birth Weight Infants Active, not recruiting NCT03184441
4 Newborn Head Molding and Later Asymmetries Active, not recruiting NCT02283229
5 Brain Characteristics Noted Prior to and Following Treatment Active, not recruiting NCT02392195
6 Osteopathic Approach Into Neonatology Ward: the NE-O Model Available NCT01902563
7 Investigating the Effectiveness of Control Frequency on and Deformational Plagiocephaly Not yet recruiting NCT02607969
8 Cranial Orthotic Device Versus Repositioning Techniques for the Management of Plagiocephaly: the CRANIO Randomized Trial Not yet recruiting NCT02370901
9 Cranial Cup Use for the Prevention of Positional Head Shape Deformity in the NICU Terminated NCT01218087
10 Hanger Helmet Study Withdrawn NCT02561728

Search NIH Clinical Center for Plagiocephaly

Genetic Tests for Plagiocephaly

Genetic tests related to Plagiocephaly:

id Genetic test Affiliating Genes
1 Plagiocephaly 29

Anatomical Context for Plagiocephaly

MalaCards organs/tissues related to Plagiocephaly:

39
Brain, Bone, Testes, Eye, Heart

Publications for Plagiocephaly

Articles related to Plagiocephaly:

(show top 50) (show all 372)
id Title Authors Year
1
Plagiocephaly Severity Scale to Aid in Clinical Treatment Recommendations. ( 28468155 )
2017
2
Discussion: Head Orthosis Therapy in Positional Plagiocephaly: Influence of Age and Severity of Asymmetry on Effect and Duration of Therapy. ( 28746284 )
2017
3
Factors influencing outcomes of the treatment of positional plagiocephaly in infants: a 7-year experience. ( 28084921 )
2017
4
Plagiocephaly and Developmental Delay: A Systematic Review. ( 28009719 )
2017
5
Comparison of endocranial morphology according to age in one-piece fronto-orbital advancement using a distraction in craniosynostotic plagiocephaly. ( 28724507 )
2017
6
Positional plagiocephaly is associated with sternocleidomastoid muscle activation in healthy term infants. ( 28236068 )
2017
7
The Role of Age and Initial Deformation on Final Cranial Asymmetry in Infants with Plagiocephaly Treated with Helmet Therapy. ( 28850946 )
2017
8
The health belief model and factors associated with adherence to treatment recommendations for positional plagiocephaly. ( 28084919 )
2017
9
Accuracy of measurements used to quantify cranial asymmetry inA deformational plagiocephaly. ( 28615136 )
2017
10
Head Orthosis Therapy in Positional Plagiocephaly: Influence of Age and Severity of Asymmetry on Effect and Duration of Therapy. ( 28746283 )
2017
11
Impact of Parent Practices of Infant Positioning on Head Orientation Profile and Development of Positional Plagiocephaly in Healthy Term Infants. ( 28375778 )
2017
12
Relationship between starting age of cranial-remolding-orthosis therapy and effectiveness of treatment in children with deformational plagiocephaly. ( 28484866 )
2017
13
Does shape affect function? Articulatory skills in babbling of infants with deformational plagiocephaly. ( 28875353 )
2017
14
Unicoronal Craniosynostosis and Plagiocephaly Correction with Fronto-orbital Bone Remodeling and Advancement. ( 28713746 )
2017
15
Deformational plagiocephaly in normal infants: a systematic review of causes and hypotheses. ( 28104626 )
2017
16
Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Management of Patients With Positional Plagiocephaly: The Role of Repositioning. ( 27759673 )
2016
17
Impact of severity and therapy onset on helmet therapy in positional plagiocephaly. ( 26724211 )
2016
18
Plagiocephaly due to Frontosphenoidal Suture Synostosis: Report of 2 Cases and Literature Review. ( 26960206 )
2016
19
Long-Term Assessment of Suturectomy in Trigonocephaly and Anterior Plagiocephaly. ( 27092924 )
2016
20
Therapy effects of head orthoses in positional plagiocephaly. ( 27595189 )
2016
21
Evidence for Use of Frontozygomaticus and Contralateral Eurion as Hand-Caliper Landmarks for Assessment of Deformational Plagiocephaly. ( 27428906 )
2016
22
Neurological assessment of Chinese infants with positional plagiocephaly using a Chinese version of the Infant Neurological International Battery (INFANIB). ( 27718070 )
2016
23
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Role of Cranial Molding Orthosis (Helmet) Therapy for Patients With Positional Plagiocephaly. ( 27776089 )
2016
24
Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Role of Cranial Molding Orthosis (Helmet) Therapy for Patients With Positional Plagiocephaly. ( 27759675 )
2016
25
An Evidence-Based Approach to Nonsynostotic Plagiocephaly. ( 27673539 )
2016
26
Plagiocephaly and Developmental Delay: The Expanding Role of the Craniofacial Surgeon. ( 27428923 )
2016
27
Malocclusion in the primary dentition in children with and without deformational plagiocephaly. ( 26795625 )
2016
28
Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Management of Patients With Positional Plagiocephaly: The Role of Physical Therapy. ( 27759674 )
2016
29
Diagnostic Yield of Routine Skull Radiographs in Infants With Deformational Plagiocephaly. ( 27136073 )
2016
30
Positional plagiocephaly following ventriculoperitoneal shunting in neonates and infancy-how serious is it? ( 27848003 )
2016
31
Clinical assessment of head orientation profile development and its relationship with positional plagiocephaly in healthy term infants - A prospective study. ( 27031440 )
2016
32
Assessment of Deformational Plagiocephaly Severity and Neonatal Developmental Delay. ( 28005729 )
2016
33
Use of external orthotic helmet therapy in positional plagiocephaly. ( 26947339 )
2016
34
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Diagnosis of Patients With Positional Plagiocephaly: The Role of Imaging. ( 27776086 )
2016
35
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Management of Patients With Positional Plagiocephaly: The Role of Physical Therapy. ( 27776088 )
2016
36
Effects of manual therapy on treatment duration and motor development in infants with severe nonsynostotic plagiocephaly: a randomised controlled pilot study. ( 27465676 )
2016
37
Positional plagiocephaly reduces parental adherence to SIDS Guidelines and inundates the health system. ( 27504717 )
2016
38
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Management of Patients With Positional Plagiocephaly: The Role of Repositioning. ( 27776087 )
2016
39
Assessment of Deformational Plagiocephaly Severity and Neonatal Developmental Delay. ( 27557465 )
2016
40
Quantitative analysis of craniofacial dysmorphology in infants with anterior synostotic plagiocephaly. ( 27541866 )
2016
41
Sonographic Analysis of Changes in Skull Shape After Cranial Molding Helmet Therapy in Infants With Deformational Plagiocephaly. ( 26928929 )
2016
42
Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Diagnosis of Patients With Positional Plagiocephaly: The Role of Imaging. ( 27759672 )
2016
43
Systematic Review and Evidence-Based Guidelines for the Management of Patients with Positional Plagiocephaly. ( 27940801 )
2016
44
Effect of fronto-orbital advancement on astigmatism in patients with anterior plagiocephaly. ( 27567360 )
2016
45
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Management of Patients With Positional Plagiocephaly: Executive Summary. ( 27759671 )
2016
46
Assessing the Cervical Range of Motion in Infants With Positional Plagiocephaly. ( 27192654 )
2016
47
Repercussions of plagiocephaly on posture, muscle flexibility and balance in children aged 3-5a88years old. ( 27329908 )
2016
48
Isolated Unilateral Frontosphenoidal Craniosynostosis: A Rare Cause of Anterior Plagiocephaly. ( 26267563 )
2015
49
Comparison of Direct and Digital Measures of Cranial Vault Asymmetry for Assessment of Plagiocephaly. ( 26267578 )
2015
50
Prevalence and Consequences of Positional Plagiocephaly and Brachycephaly. ( 26595002 )
2015

Variations for Plagiocephaly

Expression for Plagiocephaly

Search GEO for disease gene expression data for Plagiocephaly.

Pathways for Plagiocephaly

Pathways related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 34)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 FGFR1 FGFR2 FGFR3 TWIST1
2
Show member pathways
12.73 FGFR1 FGFR2 FGFR3
3
Show member pathways
12.71 FGFR1 FGFR2 FGFR3
4
Show member pathways
12.66 FGFR1 FGFR2 FGFR3
5
Show member pathways
12.55 FGFR1 FGFR2 FGFR3
6
Show member pathways
12.54 FGFR1 FGFR2 FGFR3
7
Show member pathways
12.44 FGFR1 FGFR2 FGFR3
8
Show member pathways
12.43 FGFR1 FGFR2 FGFR3
9 12.41 FGFR1 FGFR2 FGFR3
10
Show member pathways
12.39 FGFR1 FGFR2 FGFR3
11 12.36 FGFR1 FGFR2 FGFR3
12 12.36 FGFR1 FGFR2 FGFR3
13 12.32 FGFR1 FGFR2 FGFR3
14
Show member pathways
12.28 FGFR1 FGFR2 FGFR3
15
Show member pathways
12.19 FGFR1 FGFR2 FGFR3
16
Show member pathways
12.18 FGFR1 FGFR2 FGFR3
17
Show member pathways
12.11 FGFR1 FGFR2 FGFR3
18
Show member pathways
12.11 FGFR1 FGFR2 FGFR3
19
Show member pathways
12.05 FGFR1 FGFR2 FGFR3
20
Show member pathways
12.05 FGFR1 FGFR2 FGFR3
21
Show member pathways
11.94 FGFR1 FGFR2 FGFR3
22
Show member pathways
11.92 FGFR1 FGFR2 FGFR3
23
Show member pathways
11.86 FGFR1 FGFR2 FGFR3
24
Show member pathways
11.78 FGFR1 FGFR2 FGFR3
25 11.7 FGFR1 FGFR2 FGFR3
26 11.64 FGFR1 FGFR2 FGFR3
27 11.55 FGFR1 FGFR3
28 11.44 FGFR1 FGFR3
29 11.43 FGFR1 FGFR2 FGFR3
30 11.37 FGFR1 FGFR2 FGFR3
31 11.28 FGFR1 FGFR2
32 11.14 FGFR1 FGFR2 FGFR3
33 10.93 FGFR1 FGFR2 FGFR3 TWIST1
34 10.79 FGFR1 FGFR2 FGFR3

GO Terms for Plagiocephaly

Cellular components related to Plagiocephaly according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 8.8 FGFR1 FGFR2 FGFR3

Biological processes related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 41)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.86 FGFR1 FGFR2 TWIST1
2 phosphorylation GO:0016310 9.85 FGFR1 FGFR2 FGFR3
3 protein phosphorylation GO:0006468 9.85 FGFR1 FGFR2 FGFR3
4 positive regulation of GTPase activity GO:0043547 9.85 FGFR1 FGFR2 FGFR3
5 positive regulation of cell proliferation GO:0008284 9.83 FGFR1 FGFR2 FGFR3
6 MAPK cascade GO:0000165 9.76 FGFR1 FGFR2 FGFR3
7 in utero embryonic development GO:0001701 9.75 FGFR1 FGFR2 TWIST1
8 protein autophosphorylation GO:0046777 9.74 FGFR1 FGFR2 FGFR3
9 peptidyl-tyrosine phosphorylation GO:0018108 9.72 FGFR1 FGFR2 FGFR3
10 neuron migration GO:0001764 9.68 FGFR1 TWIST1
11 lung development GO:0030324 9.68 FGFR1 FGFR2
12 positive regulation of epithelial cell proliferation GO:0050679 9.67 FGFR2 TWIST1
13 inner ear morphogenesis GO:0042472 9.66 FGFR1 FGFR2
14 embryonic limb morphogenesis GO:0030326 9.65 FGFR1 TWIST1
15 bone development GO:0060348 9.65 FGFR2 TWIST1
16 ureteric bud development GO:0001657 9.65 FGFR1 FGFR2
17 phosphatidylinositol-mediated signaling GO:0048015 9.65 FGFR1 FGFR2 FGFR3
18 skeletal system morphogenesis GO:0048705 9.64 FGFR1 FGFR2
19 chondrocyte differentiation GO:0002062 9.64 FGFR1 FGFR3
20 positive regulation of cell cycle GO:0045787 9.63 FGFR1 FGFR2
21 midbrain development GO:0030901 9.63 FGFR1 FGFR2
22 phosphatidylinositol phosphorylation GO:0046854 9.63 FGFR1 FGFR2 FGFR3
23 positive regulation of cardiac muscle cell proliferation GO:0060045 9.62 FGFR1 FGFR2
24 bone mineralization GO:0030282 9.62 FGFR2 FGFR3
25 embryonic cranial skeleton morphogenesis GO:0048701 9.61 FGFR2 TWIST1
26 odontogenesis GO:0042476 9.61 FGFR2 TWIST1
27 positive regulation of MAPK cascade GO:0043410 9.61 FGFR1 FGFR2 FGFR3
28 bone morphogenesis GO:0060349 9.6 FGFR2 FGFR3
29 positive regulation of mesenchymal cell proliferation GO:0002053 9.59 FGFR1 FGFR2
30 fibroblast growth factor receptor signaling pathway GO:0008543 9.58 FGFR1 FGFR2 FGFR3
31 branching involved in salivary gland morphogenesis GO:0060445 9.56 FGFR1 FGFR2
32 lung-associated mesenchyme development GO:0060484 9.54 FGFR1 FGFR2
33 mesenchymal cell differentiation GO:0048762 9.52 FGFR1 FGFR2
34 outer ear morphogenesis GO:0042473 9.51 FGFR1 TWIST1
35 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.5 FGFR1 FGFR2 FGFR3
36 endochondral bone growth GO:0003416 9.49 FGFR2 FGFR3
37 orbitofrontal cortex development GO:0021769 9.37 FGFR1 FGFR2
38 ventricular zone neuroblast division GO:0021847 9.26 FGFR1 FGFR2
39 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0035607 9.16 FGFR1 FGFR2
40 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.13 FGFR1 FGFR2 FGFR3
41 positive regulation of phospholipase activity GO:0010518 8.8 FGFR1 FGFR2 FGFR3

Molecular functions related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.67 FGFR1 FGFR2 TWIST1
2 kinase activity GO:0016301 9.65 FGFR1 FGFR2 FGFR3
3 protein kinase activity GO:0004672 9.63 FGFR1 FGFR2 FGFR3
4 nucleotide binding GO:0000166 9.61 FGFR1 FGFR2 FGFR3
5 protein tyrosine kinase activity GO:0004713 9.58 FGFR1 FGFR2 FGFR3
6 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 FGFR1 FGFR2 FGFR3
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.5 FGFR1 FGFR2 FGFR3
8 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.43 FGFR1 FGFR2 FGFR3
9 1-phosphatidylinositol-3-kinase activity GO:0016303 9.33 FGFR1 FGFR2 FGFR3
10 fibroblast growth factor binding GO:0017134 9.13 FGFR1 FGFR2 FGFR3
11 fibroblast growth factor-activated receptor activity GO:0005007 8.8 FGFR1 FGFR2 FGFR3

Sources for Plagiocephaly

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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