MCID: PLG002
MIFTS: 46

Plague malady

Infectious category

Summaries for Plague

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Plague is an infection caused by the bacterium yersinia pestis. the bacteria are found mainly in rats and in the fleas that feed on them. people and other animals can get plague from rat or flea bites. in the past, plague destroyed entire civilizations. today plague is uncommon, due to better living conditions and antibiotics. there are three forms of plague: bubonic plague causes the tonsils, adenoids, spleen, and thymus to become inflamed. symptoms include fever, aches, chills, and tender lymph glands. in septicemic plague, bacteria multiply in the blood. it causes fever, chills, shock, and bleeding under the skin or other organs. pneumonic plague is the most serious form. bacteria enter the lungs and cause pneumonia. people with the infection can spread this form to others. this type could be a bioterror agent. lab tests can diagnose plague. treatment is a strong antibiotic. there is no vaccine. nih: national institute of allergy and infectious diseases

MalaCards: Plague, also known as yersinia infections, is related to pneumonic plague and tuberculosis. An important gene associated with Plague is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways are Peroxisomal lipid metabolism and PDGFR-beta signaling pathway. The compounds 2-(oxalyl-amino)-benzoic acid and raytide have been mentioned in the context of this disorder. Affiliated tissues include lymph node and vasculature or, and related mouse phenotype endocrine/exocrine gland.

Disease Ontology:8 A primary bacterial infectious disease that results in infection, located in lymph node, located in vasculature or located in lungs, has material basis in yersinia pestis, which is transmitted by oriental rat flea (xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted by air, transmitted by direct contact or transmitted by ingestion of contaminated undercooked food.

CDC:3 Plague is a disease that affects humans and other mammals. It is caused by the bacterium, Yersinia pestis. Humans usually get plague after being bitten by a rodent flea that is carrying the plague bacterium or by handling an animal infected with plague. Plague is infamous for killing millions of people in Europe during the Middle Ages. Today, modern antibiotics are effective in treating plague. Without prompt treatment, the disease can cause serious illness or death. Presently, human plague infections continue to occur in the western United States, but significantly more cases occur in parts of Africa and Asia.

Wikipedia:64 Plague or The plague is a disease that has a high mortality rate or a calamity with widespread and... more...

Aliases & Classifications for Plague

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 34MedlinePlus, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
plague:
Age of onset: Variable


Aliases & Descriptions:

plague 8 10 49 34 61
yersinia infections 61
yersiniosis 49


External Ids:

Disease Ontology8 DOID:3482
ICD9CM27 020.9, 020
MeSH35 D010930
NCIt40 C85015
ICD10 via Orphanet26 A20
SNOMED-CT via Orphanet58 58750007, 83436008
UMLS via Orphanet62 C0032064, C0043407
MESH via Orphanet36 D010930, D015009
ICD1025 A20, A20.9

Related Diseases for Plague

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Plague via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonic plague31.5CLEC4A
2tuberculosis30.4CXCR2, CDKN3, ACP1
3insulin resistance29.8CDKN3, PTS, PTPN1, ACP1
4septicemic plague10.5
5tularemia10.5
6cholera10.2
7smallpox10.2
8typhus10.2
9uveitis10.2
10anterior uveitis10.2
11listeriosis10.2
12ecthyma10.2
13pestis minor10.2
14measles10.1
15legionnaires' disease10.1
16typhoid fever10.1
17anthrax disease10.1
18pulmonary function10.1
19ankylosing spondylitis10.1
20reactive arthritis10.1
21arthritis10.1
22spondylitis10.1
23campylobacteriosis10.0
24shigellosis10.0
25toxoplasmosis10.0
26noonan syndrome10.0ACP1
27leopard syndrome10.0CDKN3, ACP1
28hepatitis10.0TYMP
29leishmaniasis10.0PTPN1, ACP1
30bubonic plague10.0PTPN1, ACP1, CDKN3
31polycythemia vera10.0ACP1
32diabetes mellitus10.0PTS, ACP1, PTPN1
33malaria10.0CDC25C, CDKN3, ACP1
34leiomyoma10.0TYMP
35pancreatic cancer10.0CDH3, CXCR2, TYMP
36ischemia10.0PRKCD, CDKN3, PTPRU
37ovarian cancer10.0ACP1, CDKN3, CDC25C, TYMP, PTPN1
38colorectal cancer10.0CDH3, TYMP, CDC25C, PTS
39endometrial carcinoma10.0CDKN3, TYMP, CDC25C, CDH3
40prostate cancer10.0CDKN3, CDC25C, CDH3, ACP1
41type 2 diabetes mellitus10.0PTPN1, PTS, CDC25C, ACP1, TYMP
42melanoma10.0CXCR2, CDH3, ACP1, CLEC4A, PTS
43alzheimer's disease10.0PTPRU, CXCR2, CDKN3, PTPN1, PTS
44hyperglycemia10.0CDKN3, ACP1
45hepatocellular carcinoma10.0TYMP, ACP1, CXCR2, CDH3
46stomach cancer10.0ACP1, PTS, CDH3, TYMP, CXCR2
47burkitt's lymphoma10.0ACP1, CXCR2, CDC25C
48malignant glioma10.0ACP1, CDKN3, PTPN1, PRKCD, TYMP
49ipex syndrome10.0CDC25C, PTS, CDKN3, ACOT8, ACP1
50glioblastoma multiforme10.0CXCR2, CDKN3, CDC25C, ACP1, TYMP, PTPRU

Graphical network of the top 20 diseases related to Plague:



Diseases related to plague

Clinical Features for Plague

Drugs & Therapeutics for Plague

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Plague

Drug clinical trials:

Search ClinicalTrials for Plague

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Search CenterWatch for Plague

Genetic Tests for Plague

Anatomical Context for Plague

Sources:
14FMA
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FMA organs/tissues related to Plague:

14
Lymph node, Vasculature or

Animal Models for Plague or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Plague:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.2PTPN1, PTS, CXCR2, CDH3, CDC25C, AGPS

Publications for Plague

Sources:
51PubMed
See all sources

Articles related to Plague:

(show top 50)    (show all 732)
idTitleAuthorsYear
1
Bacterial profiling of White Plague Disease in a comparative coral species framework. (23924783)
2014
2
History of infectious diseases development in the Old and the Middle Ages with the emphasis on the plague and leprosy. (23984623)
2013
3
Commentary: An experimental theatre for vaccines--Bombay in the time of plague. (23918847)
2013
4
Partial Retraction: yadBC of Yersinia pestis, a new virulence determinant for bubonic plague. (23335642)
2013
5
"Compulsive plague! pain without end!" How Richard Wagner played out his migraine in the opera Siegfried. (24336305)
2013
6
Prevalence of the crayfish plague pathogen Aphanomyces astaci in populations of the signal crayfish Pacifastacus leniusculus in France: evaluating the threat to native crayfish. (23894606)
2013
7
Distribution and epidemiology of genotypes of the crayfish plague agent Aphanomyces astaci from noble crayfish Astacus astacus in Finland. (23574706)
2013
8
A non-invasive in vivo imaging system to study dissemination of bioluminescent Yersinia pestis CO92 in a mouse model of pneumonic plague. (23063826)
2013
9
Do pathogens reduce genetic diversity of their hosts? Variable effects of sylvatic plague in black-tailed prairie dogs. (23452304)
2013
10
Officials act to secure cattle-plague virus. (22859179)
2012
11
PCR detection of the crayfish plague pathogen in narrow-clawed crayfish inhabiting Lake EA9irdir in Turkey. (22535876)
2012
12
Plague and cholera in the genomics era. (22369152)
2012
13
Roles of chaperone/usher pathways of Yersinia pestis in a murine model of plague and adhesion to host cells. (22851745)
2012
14
Construction and screening of attenuated I9phoP/Q Salmonella typhimurium vectored plague vaccine candidates. (22327496)
2012
15
Local persistence and extinction of plague in a metapopulation of great gerbil burrows, Kazakhstan. (23351373)
2012
16
Hfq-dependent, co-ordinate control of cyclic diguanylate synthesis and catabolism in the plague pathogen Yersinia pestis. (22924957)
2012
17
The long journey of cattle plague. (22467973)
2011
18
Diabetes and tuberculosis: a twenty-first century plague? (22008751)
2011
19
Notes from the field: two cases of human plague--Oregon, 2010. (21346709)
2011
20
Scurvy: historically a plague of the sailor that remains a consideration in the modern intensive care unit. (21426466)
2011
21
Plague and climate: scales matter. (21949648)
2011
22
The plague and macular degeneration. (20932580)
2010
23
Behavioural phase change in the Australian plague locust, Chortoicetes terminifera, is triggered by tactile stimulation of the antennae. (20438734)
2010
24
Plague studies in California: a review of long-term disease activity, flea-host relationships and plague ecology in the coniferous forests of the Southern Cascades and northern Sierra Nevada mountains. (20618641)
2010
25
TNFI+ and IFNI^ contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague. (20840834)
2010
26
Interannual variability of human plague occurrence in the Western United States explained by tropical and North Pacific Ocean climate variability. (20810830)
2010
27
Modelling the black death. A historical case study and implications for the epidemiology of bubonic plague. (19560967)
2009
28
The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plague. (19759820)
2009
29
Scavenging by mammalian carnivores on prairie dog colonies: implications for the spread of plague. (18945188)
2009
30
Insulin resistance. Prosperity's plague. (19608888)
2009
31
Misconceptions plague mammography. (19457849)
2009
32
Primary pneumonic plague contracted from a mountain lion carcass. (19555287)
2009
33
Prevalence of the crayfish plague pathogen Aphanomyces astaci in invasive American crayfishes in the Czech Republic. (19459897)
2009
34
An age-old paradigm challenged: old baboons generate vigorous humoral immune responses to LcrV, a plague antigen. (18566375)
2008
35
The archaeology of "plague". (18575084)
2008
36
Vaccination with F1-V fusion protein protects black-footed ferrets (Mustela nigripes) against plague upon oral challenge with Yersinia pestis. (18263816)
2008
37
Geographic distribution and ecological niche of plague in sub-Saharan Africa. (18947399)
2008
38
Waldemar Mordecai Haffkine, CIE (1860-1930): prophylactic vaccination against cholera and bubonic plague in British India. (17356724)
2007
39
Oral vaccination with salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague. (17202369)
2007
40
A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. (17913308)
2007
41
Treatments for bubonic plague: reports from seventeenth century British epidemics. (10911834)
2000
42
Cat-transmitted fatal pneumonic plague in a person who traveled from Colorado to Arizona. (8059908)
1994
43
From the Centers for Disease Control. Pneumonic plague--Arizona, 1992. (1404753)
1992
44
Possible pneumonic plague. (511127)
1979
45
Immunity in plague: protection of the vervet (Cercopithecus aethips) against pneumonic plague by the oral administration of live attenuated Yersinia pestis. (402428)
1977
46
Letter: Co-trimoxazole in bubonic plague. (4745331)
1973
47
Mediastinal lymphadenopathy in bubonic plague. (4641177)
1972
48
An Historical Retrospect: Bubonic Plague in 1901. (18745551)
1940
49
THREE CASES OF BUBONIC PLAGUE ARISING IN ENGLAND. (20768272)
1916
50
Report of a Case of Bubonic Plague. (18732733)
1902

Genetic Variations for Plague

Expression for genes affiliated with Plague

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plague

Search GEO for disease gene expression data for Plague.

Pathways for genes affiliated with Plague

Sources:
54Reactome, 38NCBI BioSystems Database
See all sources

Pathways related to Plague according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ACOT8, AGPS
210.0PTPN1, ACP1, PRKCD

Compounds for genes affiliated with Plague

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 24HMDB, 29IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Plague according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
12-(oxalyl-amino)-benzoic acid45 1111.6PTPN1, PTS
2raytide4510.5PTPN1, ACP1
3tungstate4510.5ACP1, PTPN1
4phenylphosphate45 1111.5PTPN1, ACP1
5bpv(phen)4510.4CDC25C, ACP1
6iodoacetate4510.4ACP1, PTS, PTPN1
7ammonium molybdate4510.4CDC25C, ACP1
8phosphonate4510.4PTPN1, ACP1, PTS
9cgp42112a4510.4CDC25C, ACP1
10vanadium4510.4PTPN1, ACP1
11sodium stibogluconate45 1111.4ACP1, CDKN3
12molybdate4510.3ACP1, PTPN1, CDC25C
13diphenyleneiodonium4510.3CDKN3, PTPN1, ACP1
14cycloheximide4510.3CDC25C, TYMP
15cytochalasin d45 6011.3PTPN1, PTS, ACP1, CDKN3
16cl 1004510.2PTS, ACP1, CDC25C, CDKN3
17n-acetylglucosamine4510.2CLEC4A, CHST3, MGAT1
18inositol4510.2CDKN3, CXCR2, ACP1, PTS
19p-nitrophenyl phosphate4510.1CDC25C, PTPN1, PTS, ACP1, CDKN3
20phosphothreonine4510.1PTS, CDKN3, CDC25C, ACP1, PTPN1
21sodium orthovanadate45 6011.1CDC25C, PTS, CDKN3, ACP1, PTPN1
22phosphoserine45 2411.1CDKN3, PTPN1, CDC25C, ACP1, PTS
23dithiothreitol4510.0ACP1, PTPN1, PTS
24herbimycin a45 6011.0CDKN3, CDC25C, ACP1, CXCR2
25n-ethylmaleimide45 1111.0CDC25C, CDKN3, ACP1
26glucose4510.0TYMP, CLEC4A, CDC25C
27suramin45 29 1111.9PTS, PTPN1, ACP1
28phenylarsine oxide459.9PTS, ACP1, CDC25C, CDKN3, PTPRU
29phosphoinositide459.9CDC25C, ACP1, PRKCD, CDKN3, CXCR2
30cholesterol45 29 11 2412.8MGAT1, PRKCD, CDC25C, CLEC4A, PTS, PTPN1
31cisplatin45 50 60 1112.8ACP1, PRKCD, CDKN3, TYMP, CDC25C
32superoxide45 2410.8CDC25C, CLEC4A, CXCR2, PTPN1, PRKCD
33vanadate459.8PTPRU, CDC25C, PTPN1, PTS, ACP1, CDKN3
34wortmannin459.8CDKN3, PRKCD, ACP1, CDC25C, CXCR2, TYMP
35okadaic acid45 6010.8CDC25C, ACP1, PTPN1, PTPRU, CDKN3, PRKCD
36phosphotyrosine459.8CDC25C, ACP1, PTPRU, CDKN3, PTPN1, PTS
37doxorubicin45 50 1111.8PRKCD, ACP1, TYMP, CDC25C
38sodium fluoride459.8CDKN3, CDC25C
39genistein45 29 60 2 11 2414.8CXCR2, ACP1, PTPRU, CDC25C, CDKN3
40phosphatidylinositol459.7PTPN1, ACP1, CXCR2, PRKCD, CDC25C, CDKN3
41alanine459.7CDKN3, CDC25C, CXCR2, AGPS, PTPN1, PRKCD
42atp45 2910.6PTPN1, CDKN3, TYMP, PTPRU, PRKCD, PTS
43nitric oxide45 11 2411.5CDH3, CDC25C, TYMP, PTPN1, PTS, CXCR2
44h2o2459.5PTPN1, PTS, ACP1, CDC25C, CDKN3, AGPS
45threonine459.3PRKCD, AGPS, PTS, CDKN3, PTPN1, CDC25C
46oxygen45 2410.3ACP1, PTPRU, TYMP, PTPN1, PTS, CXCR2
47calcium45 50 11 2412.1PRKCD, CDKN3, CDC25C, CDH3, CLEC4A, CXCR2
48cysteine459.1CDKN3, CDC25C, CXCR2, ACP1, PTPRU, PTS
49tyrosine459.1CDC25C, PTS, PTPN1, TYMP, CDH3, CDKN3
50serine459.0PTPRU, CXCR2, ACP1, PRKCD, PTPN1, PTS

GO Terms for genes affiliated with Plague

Sources:
16Gene Ontology
See all sources

Biological processes related to Plague according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neutrophil activationGO:04211910.1CXCR2, PRKCD
2peptidyl-tyrosine dephosphorylationGO:0353359.4PTPN1, PTPRU, CDC25C, CDKN3

Molecular functions related to Plague according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine phosphatase activityGO:0047259.7PTPN1, PTPRU, CDC25C, CDKN3

Products for genes affiliated with Plague

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Plague

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet