MCID: PLG002
MIFTS: 56

Plague malady

Infectious diseases category

Summaries for Plague

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Plague is an infection caused by the bacterium yersinia pestis. the bacteria are found mainly in rats and in the fleas that feed on them. people and other animals can get plague from rat or flea bites. in the past, plague destroyed entire civilizations. today plague is uncommon, due to better living conditions and antibiotics. there are three forms of plague: bubonic plague causes the tonsils, adenoids, spleen, and thymus to become inflamed. symptoms include fever, aches, chills, and tender lymph glands. in septicemic plague, bacteria multiply in the blood. it causes fever, chills, shock, and bleeding under the skin or other organs. pneumonic plague is the most serious form. bacteria enter the lungs and cause pneumonia. people with the infection can spread this form to others. this type could be a bioterror agent. lab tests can diagnose plague. treatment is a strong antibiotic. there is no vaccine. nih: national institute of allergy and infectious diseases

MalaCards: Plague, also known as yersinia infections, is related to bubonic plague and pneumonic plague. An important gene associated with Plague is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways are Peroxisomal lipid metabolism and PDGFR-beta signaling pathway. The compounds 2-(oxalyl-amino)-benzoic acid and raytide have been mentioned in the context of this disorder. Affiliated tissues include vasculature or, lymph node and lung, and related mouse phenotype endocrine/exocrine gland.

Disease Ontology:8 A primary bacterial infectious disease that results in infection, located in lymph node, located in vasculature or located in lungs, has material basis in yersinia pestis, which is transmitted by oriental rat flea (xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted by air, transmitted by direct contact or transmitted by ingestion of contaminated undercooked food.

CDC:3 Plague is a disease that affects humans and other mammals. It is caused by the bacterium, Yersinia pestis. Humans usually get plague after being bitten by a rodent flea that is carrying the plague bacterium or by handling an animal infected with plague. Plague is infamous for killing millions of people in Europe during the Middle Ages. Today, modern antibiotics are effective in treating plague. Without prompt treatment, the disease can cause serious illness or death. Presently, human plague infections continue to occur in the western United States, but significantly more cases occur in parts of Africa and Asia.

Wikipedia:63 Plague or The plague is a disease that has a high mortality rate or a calamity with widespread and... more...

Aliases & Classifications for Plague

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8Disease Ontology, 10DISEASES, 48Orphanet, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
plague:
Age of onset: Variable


Aliases & Descriptions:

plague 8 10 48 33 60
yersinia infections 60
yersiniosis 48


External Ids:

Disease Ontology8 DOID:3482
ICD9CM27 020.9, 020
MeSH34 D010930
NCIt39 C85015
SNOMED-CT via Orphanet57 58750007, 83436008
ICD10 via Orphanet26 A20.0, A20.1, A20.2 A20.3, A20.7, A20.8, A20.9, more
UMLS via Orphanet61 C0032064, C0043407
MESH via Orphanet35 D010930, D015009
ICD1025 A20, A20.9

Related Diseases for Plague

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17GeneCards, 18GeneDecks
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Diseases related to Plague via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1bubonic plague31.5PTPN1, ACP1, CDKN3
2pneumonic plague31.5CLEC4A
3tuberculosis30.3CXCR2, CDKN3, ACP1
4hepatitis29.8TYMP
5leishmaniasis29.8PTPN1, ACP1
6septicemic plague10.5
7tularemia10.4
8cholera10.2
9smallpox10.2
10typhus10.2
11uveitis10.2
12ecthyma10.1
13pestis minor10.1
14influenza10.1
15pneumonia10.1
16listeriosis10.1
17brucellosis10.1
18measles10.0
19legionnaires' disease10.0
20typhoid fever10.0
21anthrax disease10.0
22relapsing fever10.0
23ankylosing spondylitis10.0
24reactive arthritis10.0
25arthritis10.0
26spondylitis10.0
27noonan syndrome10.0ACP1
28leopard syndrome10.0CDKN3, ACP1
29polycythemia vera10.0ACP1
30diabetes mellitus10.0PTS, ACP1, PTPN1
31malaria10.0CDC25C, CDKN3, ACP1
32leiomyoma10.0TYMP
33insulin resistance10.0CDKN3, PTS, PTPN1, ACP1
34pancreatic cancer10.0CDH3, CXCR2, TYMP
35ischemia10.0PRKCD, CDKN3, PTPRU
36campylobacteriosis10.0
37shigellosis10.0
38toxoplasmosis10.0
39ovarian cancer10.0ACP1, CDKN3, CDC25C, TYMP, PTPN1
40colorectal cancer10.0CDH3, TYMP, CDC25C, PTS
41endometrial carcinoma10.0CDKN3, TYMP, CDC25C, CDH3
42prostate cancer10.0CDKN3, CDC25C, CDH3, ACP1
43type 2 diabetes mellitus10.0PTPN1, PTS, CDC25C, ACP1, TYMP
44melanoma10.0CXCR2, CDH3, ACP1, CLEC4A, PTS
45alzheimer's disease10.0PTPRU, CXCR2, CDKN3, PTPN1, PTS
46hyperglycemia10.0CDKN3, ACP1
47hepatocellular carcinoma10.0TYMP, ACP1, CXCR2, CDH3
48stomach cancer10.0ACP1, PTS, CDH3, TYMP, CXCR2
49burkitt's lymphoma10.0ACP1, CXCR2, CDC25C
50malignant glioma10.0ACP1, CDKN3, PTPN1, PRKCD, TYMP

Graphical network of the top 20 diseases related to Plague:



Diseases related to plague

Clinical Features for Plague

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Drugs & Therapeutics for Plague

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Plague

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Anatomical Context for Plague

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Plague:

32
Lung, Lymph node, Testes, Spleen, Skin, Thymus, Tonsil, T cells, Colon, B cells, Liver

FMA organs/tissues related to Plague:

14
Vasculature or, Lymph node

Animal Models for Plague or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Plague:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.2PTPN1, PTS, CXCR2, CDH3, CDC25C, AGPS

Publications for Plague

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Sources:
50PubMed
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Articles related to Plague:

(show top 50)    (show all 726)
idTitleAuthorsYear
1
The comprehensive diagnosis and prevention of duck plague in northwest Shandong province of China. (24135592)
2013
2
A non-invasive in vivo imaging system to study dissemination of bioluminescent Yersinia pestis CO92 in a mouse model of pneumonic plague. (23063826)
2013
3
The plague under Commodus as an unintended consequence of Roman grain market regulation. (22611582)
2012
4
Lipopolysaccharide of Yersinia pestis, the Cause of Plague: Structure, Genetics, Biological Properties. (23150803)
2012
5
A curve of thresholds governs plague epizootics in Central Asia. (22449078)
2012
6
Construction and screening of attenuated I9phoP/Q Salmonella typhimurium vectored plague vaccine candidates. (22327496)
2012
7
Local persistence and extinction of plague in a metapopulation of great gerbil burrows, Kazakhstan. (23351373)
2012
8
Hfq-dependent, co-ordinate control of cyclic diguanylate synthesis and catabolism in the plague pathogen Yersinia pestis. (22924957)
2012
9
The model of Kermack and McKendrick for the plague epidemic in Bombay and the type reproduction number with seasonality. (21404076)
2012
10
Identification of Chinese plague foci from long-term epidemiological data. (22570501)
2012
11
Lessons learned about pneumonic plague diagnosis from two outbreaks, Democratic Republic of the Congo. (21529384)
2011
12
The white plague returns to London--with a vengeance. (21168203)
2011
13
Distinct CCR2(+) Gr1(+) cells control growth of the Yersinia pestis I9yopM mutant in liver and spleen during systemic plague. (21149593)
2011
14
Diabetes and tuberculosis: a twenty-first century plague? (22008751)
2011
15
Notes from the field: two cases of human plague--Oregon, 2010. (21346709)
2011
16
Amino acid residues 196-225 of LcrV represent a plague protective epitope. (20005318)
2010
17
Comparison of mouse, guinea pig and rabbit models for evaluation of plague subunit vaccine F1+rV270. (20079562)
2010
18
Behavioural phase change in the Australian plague locust, Chortoicetes terminifera, is triggered by tactile stimulation of the antennae. (20438734)
2010
19
Plague studies in California: a review of long-term disease activity, flea-host relationships and plague ecology in the coniferous forests of the Southern Cascades and northern Sierra Nevada mountains. (20618641)
2010
20
Plague and theatre in ancient Athens. (19189430)
2009
21
A historical vignette (15). "Be proud of yourself: you have a history!" The nose and the plague. (19902859)
2009
22
His6-tagged UL35 protein of duck plague virus: expression, purification, and production of polyclonal antibody. (19478528)
2009
23
Primary pneumonic plague contracted from a mountain lion carcass. (19555287)
2009
24
The plague that won't simply go away: acanthamoeba keratitis. (19426402)
2009
25
Yersinia pestis caf1 variants and the limits of plague vaccine protection. (18347051)
2008
26
Was the 'Hittite plague' an epidemic of tularemia? (18321655)
2008
27
Pestilential complexities: understanding medieval plague. (18575079)
2008
28
Modelling outbreak control for pneumonic plague. (17121692)
2007
29
Oral vaccination with salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague. (17202369)
2007
30
A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. (17913308)
2007
31
Plague reappearance in Algeria after 50 years, 2003. (18257987)
2007
32
Paradise -- not without its plagues: overwhelming Blastomycosis pneumonia after visit to lakeside cottages in Northeastern Ontario. (15871735)
2005
33
Pestis redux: the initial years of the third bubonic plague pandemic, 1894-1901. (20712094)
2002
34
Vaccination against bubonic and pneumonic plague. (11457543)
2001
35
Diagnosis of bubonic plague by PCR in Madagascar under field conditions. (10618097)
2000
36
Antibiotic treatment of experimental pneumonic plague in mice. (9517950)
1998
37
Urban epidemic of bubonic plague in Majunga, Madagascar: epidemiological aspects. (9217697)
1997
38
A sub-unit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunized animals against pneumonic plague. (9269050)
1997
39
Cat-transmitted fatal pneumonic plague in a person who traveled from Colorado to Arizona. (8059908)
1994
40
Bubonic plague in a child presenting with fever and altered mental status. (2301801)
1990
41
Possible pneumonic plague. (511127)
1979
42
Bubonic plague--extinct disease or present danger? (335361)
1977
43
Immunity in plague: protection of the vervet (Cercopithecus aethips) against pneumonic plague by the oral administration of live attenuated Yersinia pestis. (402428)
1977
44
Bubonic plague. Report from Arizona State Department of Health. (5891377)
1965
45
Pneumonic plague in mice; the effect of polyvinylpyrrolidone. (13626940)
1959
46
Antibiotics in the treatment of bubonic and pneumonic plague in man. (13139207)
1952
47
Bubonic plague. (14880263)
1951
48
An Historical Retrospect: Bubonic Plague in 1901. (18745551)
1940
49
Bubonic Plague Outbreak in San Francisco-Year 1900. (18745023)
1939
50
Bubonic Plague in California Rodents. (18742892)
1934

Genetic Variations for Plague

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Expression for genes affiliated with Plague

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plague

Search GEO for disease gene expression data for Plague.

Pathways for genes affiliated with Plague

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Sources:
53Reactome, 37NCBI BioSystems Database
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Pathways related to Plague according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ACOT8, AGPS
210.0PTPN1, ACP1, PRKCD

Compounds for genes affiliated with Plague

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Plague according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
12-(oxalyl-amino)-benzoic acid44 1111.6PTPN1, PTS
2raytide4410.5PTPN1, ACP1
3tungstate4410.5PTPN1, ACP1
4phenylphosphate44 1111.5PTPN1, ACP1
5ammonium molybdate4410.4CDC25C, ACP1
6iodoacetate4410.4PTPN1, PTS, ACP1
7bpv(phen)4410.4CDC25C, ACP1
8phosphonate4410.4ACP1, PTS, PTPN1
9cgp42112a4410.4CDC25C, ACP1
10vanadium4410.4ACP1, PTPN1
11sodium stibogluconate44 1111.4ACP1, CDKN3
12molybdate4410.3CDC25C, ACP1, PTPN1
13diphenyleneiodonium4410.3CDKN3, ACP1, PTPN1
14cycloheximide4410.3CDC25C, TYMP
15cytochalasin d44 5911.3PTPN1, PTS, ACP1, CDKN3
16cl 1004410.2CDKN3, CDC25C, ACP1, PTS
17n-acetylglucosamine4410.2CLEC4A, CHST3, MGAT1
18inositol4410.2PTS, ACP1, CXCR2, CDKN3
19p-nitrophenyl phosphate4410.1PTPN1, PTS, ACP1, CDC25C, CDKN3
20phosphothreonine4410.1CDKN3, CDC25C, ACP1, PTS, PTPN1
21sodium orthovanadate44 5911.1CDKN3, CDC25C, ACP1, PTS, PTPN1
22phosphoserine44 2411.1CDKN3, CDC25C, ACP1, PTS, PTPN1
23dithiothreitol4410.0PTPN1, PTS, ACP1
24herbimycin a44 5911.0CDKN3, CDC25C, CXCR2, ACP1
25n-ethylmaleimide44 1111.0ACP1, CDC25C, CDKN3
26glucose4410.0TYMP, CDC25C, CLEC4A
27suramin44 28 1111.9ACP1, PTS, PTPN1
28phenylarsine oxide449.9CDKN3, CDC25C, ACP1, PTPRU, PTS
29phosphoinositide449.9PRKCD, CDKN3, CDC25C, CXCR2, ACP1
30cholesterol44 28 11 2412.8MGAT1, PRKCD, CDC25C, CLEC4A, PTS, PTPN1
31cisplatin44 49 59 1112.8PRKCD, TYMP, CDKN3, CDC25C, ACP1
32superoxide44 2410.8PRKCD, CDC25C, CLEC4A, CXCR2, PTPN1
33vanadate449.8CDKN3, CDC25C, ACP1, PTPRU, PTS, PTPN1
34wortmannin449.8PRKCD, TYMP, CDKN3, CDC25C, CXCR2, ACP1
35okadaic acid44 5910.8PRKCD, CDKN3, CDC25C, ACP1, PTPRU, PTPN1
36phosphotyrosine449.8CDKN3, CDC25C, ACP1, PTPRU, PTS, PTPN1
37doxorubicin44 49 1111.8ACP1, CDC25C, TYMP, PRKCD
38sodium fluoride449.8CDC25C, CDKN3
39genistein44 28 59 2 11 2414.8PTPRU, ACP1, CXCR2, CDC25C, CDKN3
40phosphatidylinositol449.7PTPN1, ACP1, CXCR2, CDC25C, CDKN3, PRKCD
41alanine449.7PRKCD, AGPS, CDKN3, CDC25C, CXCR2, ACP1
42atp44 2810.6PRKCD, TYMP, CDKN3, CDC25C, PTPRU, PTS
43nitric oxide44 11 2411.5PRKCD, TYMP, CDC25C, CDH3, CLEC4A, CXCR2
44h2o2449.5PRKCD, AGPS, CDKN3, CDC25C, ACP1, PTPRU
45threonine449.3PRKCD, AGPS, CDKN3, CDC25C, CXCR2, ACP1
46oxygen44 2410.3PRKCD, TYMP, CDC25C, CLEC4A, CXCR2, ACP1
47calcium44 49 11 2412.1PRKCD, CDKN3, CDC25C, CDH3, CLEC4A, CXCR2
48cysteine449.1CDC25C, CDKN3, TYMP, PRKCD, CLEC4A, CXCR2
49tyrosine449.1PRKCD, TYMP, CDKN3, CDC25C, CDH3, CXCR2
50serine449.0PRKCD, AGPS, TYMP, CDKN3, CDC25C, CLEC4A

GO Terms for genes affiliated with Plague

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16Gene Ontology
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Biological processes related to Plague according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neutrophil activationGO:04211910.1CXCR2, PRKCD
2peptidyl-tyrosine dephosphorylationGO:0353359.4PTPN1, PTPRU, CDC25C, CDKN3

Molecular functions related to Plague according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine phosphatase activityGO:0047259.7PTPN1, PTPRU, CDC25C, CDKN3

Products for genes affiliated with Plague

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Sources for Plague

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet