MCID: PLG002
MIFTS: 56

Plague malady

Infectious diseases, Rare diseases categories
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Summaries for Plague

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MedlinePlus:33 Plague is an infection caused by the bacterium yersinia pestis. the bacteria are found mainly in rats and in the fleas that feed on them. people and other animals can get plague from rat or flea bites. in the past, plague destroyed entire civilizations. today plague is uncommon, due to better living conditions and antibiotics. there are three forms of plague: bubonic plague causes the tonsils, adenoids, spleen, and thymus to become inflamed. symptoms include fever, aches, chills, and tender lymph glands. in septicemic plague, bacteria multiply in the blood. it causes fever, chills, shock, and bleeding under the skin or other organs. pneumonic plague is the most serious form. bacteria enter the lungs and cause pneumonia. people with the infection can spread this form to others. this type could be a bioterror agent. lab tests can diagnose plague. treatment is a strong antibiotic. there is no vaccine. nih: national institute of allergy and infectious diseases

MalaCards based summary: Plague, also known as yersinia infections, is related to bubonic plague and pneumonic plague. An important gene associated with Plague is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways is Phosphatases. The compounds molybdate and lactone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, vasculature or and lung, and related mouse phenotypes are cardiovascular system and endocrine/exocrine gland.

Disease Ontology:8 A primary bacterial infectious disease that results in infection, located in lymph node, located in vasculature or located in lungs, has material basis in yersinia pestis, which is transmitted by oriental rat flea (xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted by air, transmitted by direct contact or transmitted by ingestion of contaminated undercooked food.

CDC:3 Plague is a disease that affects humans and other mammals. It is caused by the bacterium, Yersinia pestis. Humans usually get plague after being bitten by a rodent flea that is carrying the plague bacterium or by handling an animal infected with plague. Plague is infamous for killing millions of people in Europe during the Middle Ages. Today, modern antibiotics are effective in treating plague. Without prompt treatment, the disease can cause serious illness or death. Presently, human plague infections continue to occur in the western United States, but significantly more cases occur in parts of Africa and Asia.

Wikipedia:65 Plague or The plague is a disease that has a high mortality rate or a calamity with widespread and... more...

Aliases & Classifications for Plague

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 33MedlinePlus, 62UMLS, 27ICD9CM, 57SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 63UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Plague, Aliases & Descriptions:

Name: Plague 8 10 48 33 62
Yersinia Infections 62
 
Yersiniosis 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

48
plague:
Age of onset: Variable


External Ids:

Disease Ontology8 DOID:3482
ICD9CM27 020, 020.9
NCIt39 C85015
MeSH34 D010930
ICD10 via Orphanet26 A20.2, A20.3, A20.7 A20.8, A20.9, A20.0, A20.1, more
UMLS via Orphanet63 C0032064, C0043407
MESH via Orphanet35 D010930, D015009
ICD1025 A20, A20.9

Related Diseases for Plague

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Diseases related to Plague via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1bubonic plague11.1
2pneumonic plague11.0
3septicemic plague10.5
4tularemia10.5
5tuberculosis10.3
6cholera10.2
7smallpox10.2
8typhus10.2
9listeriosis10.2
10brucellosis10.2
11typhoid fever10.2
12ecthyma10.2
13pestis minor10.2
14influenza10.2
15pneumonia10.2
16measles10.1
17legionnaires' disease10.1
18relapsing fever10.1
19campylobacteriosis10.0
20shigellosis10.0
21toxoplasmosis10.0
22endotheliitis10.0
23crohn's disease9.9
24hepatitis9.9
25hiv-19.9
26variola minor9.9
27leptospirosis9.9
28hemochromatosis9.9
29hantavirus pulmonary syndrome9.9
30scurvy9.9
31scrub typhus9.9
32yellow fever9.9
33blastomycosis9.9
34laryngotracheitis9.9
35swine influenza9.9
36variola major9.9
37pellagra9.9
38vaccinia9.9
39q fever9.9
40anthrax disease9.9
41botulism9.9
42keratitis9.9
43leishmaniasis9.9
44leprosy9.9
45mediastinitis9.9
46migraine9.9
47mouth disease9.9
48schistosomiasis9.9
49headache9.9
50septic shock9.9

Graphical network of the top 20 diseases related to Plague:



Diseases related to plague

Symptoms for Plague

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Drugs & Therapeutics for Plague

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Drug clinical trials:

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Genetic Tests for Plague

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Anatomical Context for Plague

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MalaCards organs/tissues related to Plague:

32
Lung, Lymph node, Testes, Spleen, Skin, Thymus, Tonsil, Neutrophil, T cells, Colon, Liver, B cells

FMA organs/tissues related to Plague:

14
Lymph node, Vasculature or

Animal Models for Plague or affiliated genes

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MGI Mouse Phenotypes related to Plague:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1NEU1, PTS, FURIN, MGAT1
2MP:00053797.8MGAT1, PTPN1, PTS, CDC25C
3MP:00053787.1CDC25C, NEU1, PTS, PTPN1, FURIN, MGAT1
4MP:00107687.0MGAT1, FURIN, PTPN1, PTS, NEU1, CDC25C

Publications for Plague

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Articles related to Plague:

(show top 50)    (show all 752)
idTitleAuthorsYear
1
Yersinia pestis and the three plague pandemics. (25253400)
2014
2
Globalism of Outbreak and Prevalence of Cattle Plague(Rinderpest) around Byengjahoran (1636-1638). (23695749)
2013
3
Plague outbreak in Libya, 2009, unrelated to plague in Algeria. (23347743)
2013
4
Magical and natural amulets in early modern plague treatises. (24195335)
2013
5
History of infectious diseases development in the Old and the Middle Ages with the emphasis on the plague and leprosy. (23984623)
2013
6
Commentary: An experimental theatre for vaccines--Bombay in the time of plague. (23918847)
2013
7
Timing and quantifying Aphanomyces astaci sporulation from the noble crayfish suffering from the crayfish plague. (23102971)
2013
8
Phagocytes and humoral immunity to pneumonic plague. (22782760)
2012
9
The in vitro evaluation of anti-plague cellular immunity by quantitative analysis of IFN-I^ synthesis and the appearance of activation molecules on the surface of T-helper cells. (22782761)
2012
10
Resistance to plague among black-tailed prairie dog populations. (21923261)
2012
11
Officials act to secure cattle-plague virus. (22859179)
2012
12
An encapsulated Yersinia pseudotuberculosis is a highly efficient vaccine against pneumonic plague. (22348169)
2012
13
The plague under Commodus as an unintended consequence of Roman grain market regulation. (22611582)
2012
14
Progress on plague vaccine development. (21670978)
2011
15
Lessons learned about pneumonic plague diagnosis from two outbreaks, Democratic Republic of the Congo. (21529384)
2011
16
Rinderpest: the end of cattle plague. (21783268)
2011
17
Detection of Yersinia pestis using real-time PCR in patients with suspected bubonicA plague. (20933595)
2011
18
Emergence, spread, persistence and fade-out of sylvatic plague in Kazakhstan. (21345866)
2011
19
Analysis of HmsH and its role in plague biofilm formation. (20093287)
2010
20
Modeling the epidemiological history of plague in Central Asia: palaeoclimatic forcing on a disease system over the past millennium. (20799946)
2010
21
Amino acid residues 196-225 of LcrV represent a plague protective epitope. (20005318)
2010
22
The smpB-ssrA mutant of Yersinia pestis functions as a live attenuated vaccine to protect mice against pulmonary plague infection. (20065026)
2010
23
Paleoclimate and bubonic plague: a forewarning of future risk? (24576348)
2010
24
Modelling the black death. A historical case study and implications for the epidemiology of bubonic plague. (19560967)
2009
25
A forgotten plague: making sense of dancing mania. (19238695)
2009
26
Tularemia, plague, yersiniosis, and Tyzzer's disease in wild rodents and lagomorphs in Canada: a review. (20190973)
2009
27
Complete nucleotide sequence of the duck plague virus gE gene. (19089586)
2009
28
Oropsylla hirsuta (Siphonaptera: Ceratophyllidae) can support plague epizootics in black-tailed prairie dogs (Cynomys ludovicianus) by early-phase transmission of Yersinia pestis. (18454591)
2008
29
Effective plague vaccination via oral delivery of plant cells expressing F1-V antigens in chloroplasts. (18505806)
2008
30
Transverse--Harris--lines in a skeletal population from the 1711 Danish plague site. (18712153)
2008
31
Ocular plague (Yersinia pestis) in mule deer (Odocoileus hemionus) from Wyoming and Oregon. (18957655)
2008
32
Oral vaccination against bubonic plague using a live avirulent Yersinia pseudotuberculosis strain. (18505804)
2008
33
Prevalence and abundance of fleas in black-tailed prairie dog burrows: implications for the transmission of plague (Yersinia pestis). (18605787)
2008
34
Waldemar Mordecai Haffkine, CIE (1860-1930): prophylactic vaccination against cholera and bubonic plague in British India. (17356724)
2007
35
Pneumonic plague. (16737113)
2006
36
Respiratory immunity is an important component of protection elicited by subunit vaccination against pneumonic plague. (16377037)
2006
37
Pestis redux: the initial years of the third bubonic plague pandemic, 1894-1901. (20712094)
2002
38
Richard Pearson Strong and the Manchurian epidemic of pneumonic plague, 1910-1911. (2671146)
1989
39
Bubonic plague in nineteenth-century China. (11620272)
1988
40
Bubonic plague--extinct disease or present danger? (335361)
1977
41
Bubonic plague misdiagnosed as tularemia. Retrospective serologic diagnosis. (4678367)
1972
42
Bubonic plague in the Southwestern United States. A review of recent experience. (4924535)
1970
43
The Black Death. New insights into 18th century attitudes toward Bubonic Plague. (4876738)
1968
44
Pneumonic plague in mice; the effect of polyvinylpyrrolidone. (13626940)
1959
45
A case of anthrax septicaemia resembling bubonic plague. (13231799)
1954
46
Concerning Costs of Bubonic Plague Control. (18746967)
1945
47
The Thermoprecipitin Method in the Diagnosis of Bubonic Plague in Cadavers. (20474584)
1914
48
FOUR CASES OF PNEUMONIC PLAGUE. (20765317)
1910
49
Protection of India from Invasion by Bubonic Plague. (19973330)
1908
50
Report of a Case of Bubonic Plague. (18732733)
1902

Variations for Plague

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Expression for genes affiliated with Plague

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Expression patterns in normal tissues for genes affiliated with Plague

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Pathways for genes affiliated with Plague

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Pathways related to Plague according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CDC25C, PTPN1

Compounds for genes affiliated with Plague

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Compounds related to Plague according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1molybdate449.9CDC25C, PTPN1
2lactone449.9NEU1, PTPN1
3con a449.9NEU1, FURIN
4peroxynitrite449.9CDC25C, PTPN1
5tunicamycin44 6110.8NEU1, PTPN1
6mannose 6-phosphate44 2410.7FURIN, NEU1
7n-ethylmaleimide44 1110.7NEU1, CDC25C
82-(oxalyl-amino)-benzoic acid44 1110.7PTPN1, PTS
9iodoacetate449.6PTPN1, PTS
10n-acetylglucosamine449.6NEU1, MGAT1
11phosphonate449.6PTS, PTPN1
12cl 100449.5PTS, CDC25C
13fluorescein44 1110.5NEU1, PTS
14suramin44 28 1111.5PTS, PTPN1
15polyacrylamide449.5NEU1, PTPN1, FURIN
16phenylarsine oxide449.5CDC25C, PTS
17asparagine449.5PTS, FURIN
18superoxide44 2410.4FURIN, PTPN1, CDC25C
19Water249.3PTPN1, NEU1, CDC25C
20mannose449.2NEU1, MGAT1
21dithiothreitol449.2FURIN, PTPN1, PTS
22alanine449.2CDC25C, PTPN1, FURIN
23cgmp44 2810.2CDC25C, PTS
24p-nitrophenyl phosphate449.2CDC25C, PTS, PTPN1
25phosphothreonine449.2PTPN1, PTS, CDC25C
26sodium orthovanadate44 6110.2CDC25C, PTS, PTPN1
27phosphoserine44 2410.2CDC25C, PTS, PTPN1
28vanadate449.1CDC25C, PTS, PTPN1
29cytochalasin d44 6110.1NEU1, PTS, PTPN1
30phosphotyrosine449.1CDC25C, PTS, PTPN1
31proline449.1PTPN1, PTS, CDC25C
32aspartate449.0CDC25C, PTS, FURIN
33heparin44 28 24 1112.0NEU1, PTS, FURIN
34zinc44 2410.0FURIN, PTPN1, PTS
35hydrogen44 2410.0PTS, PTPN1, MGAT1
36nitric oxide44 24 1110.9CDC25C, PTS, PTPN1
37estrogen448.8NEU1, PTPN1, FURIN
38oxygen44 249.7PTPN1, PTS, CDC25C
39atp44 289.7CDC25C, PTS, PTPN1
40phenylalanine448.7CDC25C, PTS, PTPN1, FURIN
41arginine448.7FURIN, PTPN1, PTS, CDC25C
42threonine448.7FURIN, PTPN1, PTS, CDC25C
43h2o2448.6PTPN1, PTS, NEU1, CDC25C
44tyrosine448.6FURIN, PTPN1, PTS, CDC25C
45calcium44 50 24 1111.4FURIN, PTPN1, PTS, CDC25C
46cysteine448.2FURIN, PTPN1, PTS, NEU1, CDC25C
47serine448.2CDC25C, NEU1, PTS, PTPN1, FURIN
48cholesterol44 28 24 1111.1CDC25C, PTS, PTPN1, FURIN, MGAT1
49lipid448.1MGAT1, FURIN, PTPN1, PTS, CDC25C

GO Terms for genes affiliated with Plague

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Biological processes related to Plague according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine dephosphorylationGO:0353359.5CDC25C, PTPN1
2regulation of signal transductionGO:0099669.3PTPN1, FURIN

Molecular functions related to Plague according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine phosphatase activityGO:0047259.5CDC25C, PTPN1

Products for genes affiliated with Plague

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Sources for Plague

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet