MCID: PLG002
MIFTS: 47

Plague malady

Infectious diseases, Rare diseases categories

Aliases & Classifications for Plague

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Sources:
9Disease Ontology, 11DISEASES, 47Orphanet, 32MedlinePlus, 3CDC, 60UMLS, 55SNOMED-CT, 38NCIt, 27ICD9CM, 33MeSH, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet, 25ICD10
See all sources

Plague, Aliases & Descriptions:

Name: Plague 9 11 47 32 3 60
Yersiniosis 47 3
 
Yersinia Infections 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

47
plague:
Age of onset: All ages


External Ids:

Disease Ontology9 DOID:3482
NCIt38 C85015
ICD9CM27 020, 020.9
MeSH33 D010930
Orphanet47 707
ICD10 via Orphanet26 A20.2, A20.3, A20.7 A20.8, A20.9, A20.0, A20.1, more
UMLS via Orphanet61 C0032064, C0043407
MESH via Orphanet34 D010930, D015009
ICD1025 A20, A20.9

Summaries for Plague

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MedlinePlus:32 Plague is an infection caused by the bacterium yersinia pestis. the bacteria are found mainly in rats and in the fleas that feed on them. people and other animals can get plague from rat or flea bites. in the past, plague destroyed entire civilizations. today plague is uncommon, due to better living conditions and antibiotics. there are three forms of plague: bubonic plague causes the tonsils, adenoids, spleen, and thymus to become inflamed. symptoms include fever, aches, chills, and tender lymph glands. in septicemic plague, bacteria multiply in the blood. it causes fever, chills, shock, and bleeding under the skin or other organs. pneumonic plague is the most serious form. bacteria enter the lungs and cause pneumonia. people with the infection can spread this form to others. this type could be a bioterror agent. lab tests can diagnose plague. treatment is a strong antibiotic. there is no vaccine. nih: national institute of allergy and infectious diseases

MalaCards based summary: Plague, also known as yersiniosis, is related to bubonic plague and pneumonic plague. An important gene associated with Plague is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways is Phosphatases. The compounds molybdate and lactone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, vasculature or and lung, and related mouse phenotypes are cardiovascular system and endocrine/exocrine gland.

Disease Ontology:9 A primary bacterial infectious disease that results in infection, located in lymph node, located in vasculature or located in lungs, has material basis in yersinia pestis, which is transmitted by oriental rat flea (xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted by air, transmitted by direct contact or transmitted by ingestion of contaminated undercooked food.

Related Diseases for Plague

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Graphical network of the top 20 diseases related to Plague:



Diseases related to plague

Symptoms for Plague

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Drugs & Therapeutics for Plague

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Drug clinical trials:

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Genetic Tests for Plague

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Anatomical Context for Plague

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MalaCards organs/tissues related to Plague:

31
Lung, Lymph node, Testes, Spleen, Skin, Thymus, Tonsil, Neutrophil, T cells, Colon, Liver, B cells

FMA organs/tissues related to Plague:

14
Lymph node, Vasculature or

Animal Models for Plague or affiliated genes

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MGI Mouse Phenotypes related to Plague:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1NEU1, PTS, FURIN, MGAT1
2MP:00053797.8MGAT1, PTPN1, PTS, CDC25C
3MP:00053787.1CDC25C, NEU1, PTS, PTPN1, FURIN, MGAT1
4MP:00107687.0MGAT1, FURIN, PTPN1, PTS, NEU1, CDC25C

Publications for Plague

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Articles related to Plague:

(show top 50)    (show all 768)
idTitleAuthorsYear
1
Effects of Land Use on Plague (Yersinia pestis) Activity in Rodents in Tanzania. (25711606)
2015
2
Primary case of human pneumonic plague occurring in a Himalayan marmot natural focus area Gansu Province, China. (25555623)
2015
3
Yersinia pestis and the three plague pandemics. (25253400)
2014
4
Globalism of Outbreak and Prevalence of Cattle Plague(Rinderpest) around Byengjahoran (1636-1638). (23695749)
2013
5
Plague outbreak in Libya, 2009, unrelated to plague in Algeria. (23347743)
2013
6
Magical and natural amulets in early modern plague treatises. (24195335)
2013
7
History of infectious diseases development in the Old and the Middle Ages with the emphasis on the plague and leprosy. (23984623)
2013
8
Commentary: An experimental theatre for vaccines--Bombay in the time of plague. (23918847)
2013
9
Timing and quantifying Aphanomyces astaci sporulation from the noble crayfish suffering from the crayfish plague. (23102971)
2013
10
Phagocytes and humoral immunity to pneumonic plague. (22782760)
2012
11
The in vitro evaluation of anti-plague cellular immunity by quantitative analysis of IFN-I^ synthesis and the appearance of activation molecules on the surface of T-helper cells. (22782761)
2012
12
Resistance to plague among black-tailed prairie dog populations. (21923261)
2012
13
Officials act to secure cattle-plague virus. (22859179)
2012
14
An encapsulated Yersinia pseudotuberculosis is a highly efficient vaccine against pneumonic plague. (22348169)
2012
15
Progress on plague vaccine development. (21670978)
2011
16
Lessons learned about pneumonic plague diagnosis from two outbreaks, Democratic Republic of the Congo. (21529384)
2011
17
Rinderpest: the end of cattle plague. (21783268)
2011
18
Detection of Yersinia pestis using real-time PCR in patients with suspected bubonicA plague. (20933595)
2011
19
Emergence, spread, persistence and fade-out of sylvatic plague in Kazakhstan. (21345866)
2011
20
Analysis of HmsH and its role in plague biofilm formation. (20093287)
2010
21
Modeling the epidemiological history of plague in Central Asia: palaeoclimatic forcing on a disease system over the past millennium. (20799946)
2010
22
Amino acid residues 196-225 of LcrV represent a plague protective epitope. (20005318)
2010
23
The smpB-ssrA mutant of Yersinia pestis functions as a live attenuated vaccine to protect mice against pulmonary plague infection. (20065026)
2010
24
Paleoclimate and bubonic plague: a forewarning of future risk? (24576348)
2010
25
Modelling the black death. A historical case study and implications for the epidemiology of bubonic plague. (19560967)
2009
26
A forgotten plague: making sense of dancing mania. (19238695)
2009
27
Tularemia, plague, yersiniosis, and Tyzzer's disease in wild rodents and lagomorphs in Canada: a review. (20190973)
2009
28
Complete nucleotide sequence of the duck plague virus gE gene. (19089586)
2009
29
Oropsylla hirsuta (Siphonaptera: Ceratophyllidae) can support plague epizootics in black-tailed prairie dogs (Cynomys ludovicianus) by early-phase transmission of Yersinia pestis. (18454591)
2008
30
Effective plague vaccination via oral delivery of plant cells expressing F1-V antigens in chloroplasts. (18505806)
2008
31
Transverse--Harris--lines in a skeletal population from the 1711 Danish plague site. (18712153)
2008
32
Ocular plague (Yersinia pestis) in mule deer (Odocoileus hemionus) from Wyoming and Oregon. (18957655)
2008
33
Oral vaccination against bubonic plague using a live avirulent Yersinia pseudotuberculosis strain. (18505804)
2008
34
Prevalence and abundance of fleas in black-tailed prairie dog burrows: implications for the transmission of plague (Yersinia pestis). (18605787)
2008
35
Waldemar Mordecai Haffkine, CIE (1860-1930): prophylactic vaccination against cholera and bubonic plague in British India. (17356724)
2007
36
Pneumonic plague. (16737113)
2006
37
Respiratory immunity is an important component of protection elicited by subunit vaccination against pneumonic plague. (16377037)
2006
38
Pestis redux: the initial years of the third bubonic plague pandemic, 1894-1901. (20712094)
2002
39
Richard Pearson Strong and the Manchurian epidemic of pneumonic plague, 1910-1911. (2671146)
1989
40
Bubonic plague in nineteenth-century China. (11620272)
1988
41
Bubonic plague--extinct disease or present danger? (335361)
1977
42
Bubonic plague misdiagnosed as tularemia. Retrospective serologic diagnosis. (4678367)
1972
43
Bubonic plague in the Southwestern United States. A review of recent experience. (4924535)
1970
44
Pneumonic plague in mice; the effect of polyvinylpyrrolidone. (13626940)
1959
45
A case of anthrax septicaemia resembling bubonic plague. (13231799)
1954
46
Concerning Costs of Bubonic Plague Control. (18746967)
1945
47
The Thermoprecipitin Method in the Diagnosis of Bubonic Plague in Cadavers. (20474584)
1914
48
FOUR CASES OF PNEUMONIC PLAGUE. (20765317)
1910
49
Protection of India from Invasion by Bubonic Plague. (19973330)
1908
50
Report of a Case of Bubonic Plague. (18732733)
1902

Variations for Plague

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Expression for genes affiliated with Plague

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Search GEO for disease gene expression data for Plague.

Pathways for genes affiliated with Plague

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Pathways related to Plague according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CDC25C, PTPN1

Compounds for genes affiliated with Plague

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Compounds related to Plague according to GeneCards Suite gene sharing:

(show all 49)
idCompoundScoreTop Affiliating Genes
1molybdate439.9CDC25C, PTPN1
2lactone439.9NEU1, PTPN1
3con a439.9NEU1, FURIN
4peroxynitrite439.9CDC25C, PTPN1
5tunicamycin43 5910.8NEU1, PTPN1
6mannose 6-phosphate43 2410.7FURIN, NEU1
7n-ethylmaleimide43 1210.7NEU1, CDC25C
82-(oxalyl-amino)-benzoic acid43 1210.7PTPN1, PTS
9iodoacetate439.6PTPN1, PTS
10n-acetylglucosamine439.6NEU1, MGAT1
11phosphonate439.6PTS, PTPN1
12cl 100439.5PTS, CDC25C
13fluorescein43 1210.5NEU1, PTS
14suramin43 28 1211.5PTS, PTPN1
15polyacrylamide439.5NEU1, PTPN1, FURIN
16phenylarsine oxide439.5CDC25C, PTS
17asparagine439.5PTS, FURIN
18superoxide43 2410.4FURIN, PTPN1, CDC25C
19Water249.3PTPN1, NEU1, CDC25C
20mannose439.2NEU1, MGAT1
21dithiothreitol439.2FURIN, PTPN1, PTS
22alanine439.2CDC25C, PTPN1, FURIN
23cgmp43 2810.2CDC25C, PTS
24p-nitrophenyl phosphate439.2CDC25C, PTS, PTPN1
25phosphothreonine439.2PTPN1, PTS, CDC25C
26sodium orthovanadate43 5910.2CDC25C, PTS, PTPN1
27phosphoserine43 2410.2CDC25C, PTS, PTPN1
28vanadate439.1CDC25C, PTS, PTPN1
29cytochalasin d43 5910.1NEU1, PTS, PTPN1
30phosphotyrosine439.1CDC25C, PTS, PTPN1
31proline439.1PTPN1, PTS, CDC25C
32aspartate439.0CDC25C, PTS, FURIN
33heparin43 28 24 1212.0NEU1, PTS, FURIN
34zinc43 2410.0FURIN, PTPN1, PTS
35hydrogen43 2410.0PTS, PTPN1, MGAT1
36nitric oxide43 24 1210.9CDC25C, PTS, PTPN1
37estrogen438.8NEU1, PTPN1, FURIN
38oxygen43 249.7PTPN1, PTS, CDC25C
39atp43 289.7CDC25C, PTS, PTPN1
40phenylalanine438.7CDC25C, PTS, PTPN1, FURIN
41arginine438.7FURIN, PTPN1, PTS, CDC25C
42threonine438.7FURIN, PTPN1, PTS, CDC25C
43h2o2438.6PTPN1, PTS, NEU1, CDC25C
44tyrosine438.6FURIN, PTPN1, PTS, CDC25C
45calcium43 49 24 1211.4FURIN, PTPN1, PTS, CDC25C
46cysteine438.2FURIN, PTPN1, PTS, NEU1, CDC25C
47serine438.2CDC25C, NEU1, PTS, PTPN1, FURIN
48cholesterol43 28 24 1211.1CDC25C, PTS, PTPN1, FURIN, MGAT1
49lipid438.1MGAT1, FURIN, PTPN1, PTS, CDC25C

GO Terms for genes affiliated with Plague

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Biological processes related to Plague according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine dephosphorylationGO:00353359.5CDC25C, PTPN1
2regulation of signal transductionGO:00099669.3PTPN1, FURIN

Molecular functions related to Plague according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine phosphatase activityGO:00047259.5CDC25C, PTPN1

Products for genes affiliated with Plague

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Sources for Plague

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet