MCID: PLG002
MIFTS: 56

Plague malady

Infectious diseases, Rare diseases categories
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Summaries for Plague

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8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Plague is an infection caused by the bacterium yersinia pestis. the bacteria are found mainly in rats and in the fleas that feed on them. people and other animals can get plague from rat or flea bites. in the past, plague destroyed entire civilizations. today plague is uncommon, due to better living conditions and antibiotics. there are three forms of plague: bubonic plague causes the tonsils, adenoids, spleen, and thymus to become inflamed. symptoms include fever, aches, chills, and tender lymph glands. in septicemic plague, bacteria multiply in the blood. it causes fever, chills, shock, and bleeding under the skin or other organs. pneumonic plague is the most serious form. bacteria enter the lungs and cause pneumonia. people with the infection can spread this form to others. this type could be a bioterror agent. lab tests can diagnose plague. treatment is a strong antibiotic. there is no vaccine. nih: national institute of allergy and infectious diseases

MalaCards: Plague, also known as yersinia infections, is related to bubonic plague and pneumonic plague. An important gene associated with Plague is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways is Phosphatases. The compounds molybdate and lactone have been mentioned in the context of this disorder. Affiliated tissues include vasculature or, lymph node and lung, and related mouse phenotypes are cardiovascular system and endocrine/exocrine gland.

Disease Ontology:8 A primary bacterial infectious disease that results in infection, located in lymph node, located in vasculature or located in lungs, has material basis in yersinia pestis, which is transmitted by oriental rat flea (xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted by air, transmitted by direct contact or transmitted by ingestion of contaminated undercooked food.

CDC:4 Plague is a disease that affects humans and other mammals. It is caused by the bacterium, Yersinia pestis. Humans usually get plague after being bitten by a rodent flea that is carrying the plague bacterium or by handling an animal infected with plague. Plague is infamous for killing millions of people in Europe during the Middle Ages. Today, modern antibiotics are effective in treating plague. Without prompt treatment, the disease can cause serious illness or death. Presently, human plague infections continue to occur in the western United States, but significantly more cases occur in parts of Africa and Asia.

Wikipedia:65 Plague or The plague is a disease that has a high mortality rate or a calamity with widespread and... more...

Aliases & Classifications for Plague

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8Disease Ontology, 10DISEASES, 49Orphanet, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 59SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

49
plague:
Age of onset: Variable


Aliases & Descriptions:

plague 8 10 49 34 62
yersinia infections 62
yersiniosis 49


External Ids:

Disease Ontology8 DOID:3482
ICD9CM27 020.9, 020
MeSH35 D010930
NCIt40 C85015
SNOMED-CT via Orphanet59 58750007, 83436008
ICD10 via Orphanet26 A20.0, A20.1, A20.2 A20.3, A20.7, A20.8, A20.9, more
UMLS via Orphanet63 C0032064, C0043407
MESH via Orphanet36 D010930, D015009
ICD1025 A20, A20.9

Related Diseases for Plague

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Plague:



Diseases related to plague

Symptoms for Plague

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Drugs & Therapeutics for Plague

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Plague

Search NIH Clinical Center for Plague

Genetic Tests for Plague

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Anatomical Context for Plague

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Plague:

33
Lung, Lymph node, Testes, Spleen, Skin, Thymus, Tonsil, T cells, Colon, B cells, Liver

FMA organs/tissues related to Plague:

14
Vasculature or, Lymph node

Animal Models for Plague or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Plague:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1MGAT1, FURIN, PTS, NEU1
2MP:00053797.8PTS, PTPN1, MGAT1, CDC25C
3MP:00053787.1MGAT1, FURIN, PTPN1, PTS, NEU1, CDC25C
4MP:00107687.0CDC25C, NEU1, PTS, PTPN1, MGAT1, FURIN

Publications for Plague

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52PubMed
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Articles related to Plague:

(show top 50)    (show all 715)
idTitleAuthorsYear
1
Globalism of Outbreak and Prevalence of Cattle Plague(Rinderpest) around Byengjahoran (1636-1638). (23695749)
2013
2
Plague outbreak in Libya, 2009, unrelated to plague in Algeria. (23347743)
2013
3
Magical and natural amulets in early modern plague treatises. (24195335)
2013
4
History of infectious diseases development in the Old and the Middle Ages with the emphasis on the plague and leprosy. (23984623)
2013
5
Commentary: An experimental theatre for vaccines--Bombay in the time of plague. (23918847)
2013
6
Timing and quantifying Aphanomyces astaci sporulation from the noble crayfish suffering from the crayfish plague. (23102971)
2013
7
Phagocytes and humoral immunity to pneumonic plague. (22782760)
2012
8
The in vitro evaluation of anti-plague cellular immunity by quantitative analysis of IFN-I^ synthesis and the appearance of activation molecules on the surface of T-helper cells. (22782761)
2012
9
Resistance to plague among black-tailed prairie dog populations. (21923261)
2012
10
Officials act to secure cattle-plague virus. (22859179)
2012
11
An encapsulated Yersinia pseudotuberculosis is a highly efficient vaccine against pneumonic plague. (22348169)
2012
12
The plague under Commodus as an unintended consequence of Roman grain market regulation. (22611582)
2012
13
Progress on plague vaccine development. (21670978)
2011
14
Lessons learned about pneumonic plague diagnosis from two outbreaks, Democratic Republic of the Congo. (21529384)
2011
15
Rinderpest: the end of cattle plague. (21783268)
2011
16
Detection of Yersinia pestis using real-time PCR in patients with suspected bubonicA plague. (20933595)
2011
17
Emergence, spread, persistence and fade-out of sylvatic plague in Kazakhstan. (21345866)
2011
18
Analysis of HmsH and its role in plague biofilm formation. (20093287)
2010
19
Modeling the epidemiological history of plague in Central Asia: palaeoclimatic forcing on a disease system over the past millennium. (20799946)
2010
20
Amino acid residues 196-225 of LcrV represent a plague protective epitope. (20005318)
2010
21
The smpB-ssrA mutant of Yersinia pestis functions as a live attenuated vaccine to protect mice against pulmonary plague infection. (20065026)
2010
22
Modelling the black death. A historical case study and implications for the epidemiology of bubonic plague. (19560967)
2009
23
A forgotten plague: making sense of dancing mania. (19238695)
2009
24
Tularemia, plague, yersiniosis, and Tyzzer's disease in wild rodents and lagomorphs in Canada: a review. (20190973)
2009
25
Complete nucleotide sequence of the duck plague virus gE gene. (19089586)
2009
26
The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plague. (19759820)
2009
27
Oropsylla hirsuta (Siphonaptera: Ceratophyllidae) can support plague epizootics in black-tailed prairie dogs (Cynomys ludovicianus) by early-phase transmission of Yersinia pestis. (18454591)
2008
28
Effective plague vaccination via oral delivery of plant cells expressing F1-V antigens in chloroplasts. (18505806)
2008
29
Transverse--Harris--lines in a skeletal population from the 1711 Danish plague site. (18712153)
2008
30
Ocular plague (Yersinia pestis) in mule deer (Odocoileus hemionus) from Wyoming and Oregon. (18957655)
2008
31
Oral vaccination against bubonic plague using a live avirulent Yersinia pseudotuberculosis strain. (18505804)
2008
32
Prevalence and abundance of fleas in black-tailed prairie dog burrows: implications for the transmission of plague (Yersinia pestis). (18605787)
2008
33
Waldemar Mordecai Haffkine, CIE (1860-1930): prophylactic vaccination against cholera and bubonic plague in British India. (17356724)
2007
34
Pneumonic plague. (16737113)
2006
35
Respiratory immunity is an important component of protection elicited by subunit vaccination against pneumonic plague. (16377037)
2006
36
Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV. (16861680)
2006
37
Pestis redux: the initial years of the third bubonic plague pandemic, 1894-1901. (20712094)
2002
38
Bubonic plague in a child presenting with fever and altered mental status. (2301801)
1990
39
Richard Pearson Strong and the Manchurian epidemic of pneumonic plague, 1910-1911. (2671146)
1989
40
Bubonic plague--extinct disease or present danger? (335361)
1977
41
Bubonic plague misdiagnosed as tularemia. Retrospective serologic diagnosis. (4678367)
1972
42
Bubonic plague in the Southwestern United States. A review of recent experience. (4924535)
1970
43
The Black Death. New insights into 18th century attitudes toward Bubonic Plague. (4876738)
1968
44
Pneumonic plague in mice; the effect of polyvinylpyrrolidone. (13626940)
1959
45
A case of anthrax septicaemia resembling bubonic plague. (13231799)
1954
46
Concerning Costs of Bubonic Plague Control. (18746967)
1945
47
The Thermoprecipitin Method in the Diagnosis of Bubonic Plague in Cadavers. (20474584)
1914
48
FOUR CASES OF PNEUMONIC PLAGUE. (20765317)
1910
49
Protection of India from Invasion by Bubonic Plague. (19973330)
1908
50
Report of a Case of Bubonic Plague. (18732733)
1902

Variations for Plague

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Expression for genes affiliated with Plague

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plague

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Pathways for genes affiliated with Plague

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50PathCards, 5Cell Signaling Technology
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Pathways related to Plague according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CDC25C, PTPN1

Compounds for genes affiliated with Plague

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Sources:
45Novoseek, 61Tocris Bioscience, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB
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Compounds related to Plague according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1molybdate459.9CDC25C, PTPN1
2lactone459.9NEU1, PTPN1
3con a459.9NEU1, FURIN
4peroxynitrite459.9CDC25C, PTPN1
5tunicamycin45 6110.8NEU1, PTPN1
6mannose 6-phosphate45 2410.7FURIN, NEU1
7n-ethylmaleimide45 1110.7NEU1, CDC25C
82-(oxalyl-amino)-benzoic acid45 1110.7PTPN1, PTS
9iodoacetate459.6PTPN1, PTS
10n-acetylglucosamine459.6NEU1, MGAT1
11phosphonate459.6PTS, PTPN1
12cl 100459.5PTS, CDC25C
13fluorescein45 1110.5NEU1, PTS
14suramin45 29 1111.5PTS, PTPN1
15polyacrylamide459.5NEU1, PTPN1, FURIN
16phenylarsine oxide459.5CDC25C, PTS
17asparagine459.5PTS, FURIN
18superoxide45 2410.4FURIN, PTPN1, CDC25C
19Water249.3PTPN1, NEU1, CDC25C
20mannose459.2NEU1, MGAT1
21dithiothreitol459.2FURIN, PTPN1, PTS
22alanine459.2CDC25C, PTPN1, FURIN
23cgmp45 2910.2CDC25C, PTS
24p-nitrophenyl phosphate459.2CDC25C, PTS, PTPN1
25phosphothreonine459.2PTPN1, PTS, CDC25C
26sodium orthovanadate45 6110.2CDC25C, PTS, PTPN1
27phosphoserine45 2410.2CDC25C, PTS, PTPN1
28vanadate459.1CDC25C, PTS, PTPN1
29cytochalasin d45 6110.1NEU1, PTS, PTPN1
30phosphotyrosine459.1CDC25C, PTS, PTPN1
31proline459.1PTPN1, PTS, CDC25C
32aspartate459.0CDC25C, PTS, FURIN
33heparin45 29 24 1112.0NEU1, PTS, FURIN
34zinc45 2410.0FURIN, PTPN1, PTS
35hydrogen45 2410.0PTS, PTPN1, MGAT1
36nitric oxide45 24 1110.9CDC25C, PTS, PTPN1
37estrogen458.8NEU1, PTPN1, FURIN
38oxygen45 249.7PTPN1, PTS, CDC25C
39atp45 299.7CDC25C, PTS, PTPN1
40phenylalanine458.7CDC25C, PTS, PTPN1, FURIN
41arginine458.7FURIN, PTPN1, PTS, CDC25C
42threonine458.7FURIN, PTPN1, PTS, CDC25C
43h2o2458.6PTPN1, PTS, NEU1, CDC25C
44tyrosine458.6FURIN, PTPN1, PTS, CDC25C
45calcium45 51 24 1111.4FURIN, PTPN1, PTS, CDC25C
46cysteine458.2FURIN, PTPN1, PTS, NEU1, CDC25C
47serine458.2CDC25C, NEU1, PTS, PTPN1, FURIN
48cholesterol45 29 24 1111.1CDC25C, PTS, PTPN1, FURIN, MGAT1
49lipid458.1MGAT1, FURIN, PTPN1, PTS, CDC25C

GO Terms for genes affiliated with Plague

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16Gene Ontology
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Biological processes related to Plague according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine dephosphorylationGO:0353359.5CDC25C, PTPN1
2regulation of signal transductionGO:0099669.3PTPN1, FURIN

Molecular functions related to Plague according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine phosphatase activityGO:0047259.5CDC25C, PTPN1

Products for genes affiliated with Plague

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  • Antibodies
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Sources for Plague

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet