MCID: PLS016
MIFTS: 49

Plasma Cell Leukemia malady

Rare diseases, Cancer diseases categories

Summaries for Plasma Cell Leukemia

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Plasma cell leukemia (pcl) is a rare and aggressive form of multiple myeloma that involves high levels of plasma cells circulating in the peripheral blood. the signs and symptoms of pcl include aggressive clinical features, such as extramedullary disease, bone marrow failure, advanced stage disease and expression of distinct immunophenotypic markers. different types of treatments are available for patients with pcl. some treatments are standard (the currently used treatment), and some are being tested in clinical trials. for detailed information on the available treatment options, please visit the following link. http://www.cancer.gov/cancertopics/pdq/treatment/myeloma/patient/page4 last updated: 2/20/2014

MalaCards: Plasma Cell Leukemia, also known as leukemia, plasma cell, is related to leukemia and multiple myeloma. An important gene associated with Plasma Cell Leukemia is MAF (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog), and among its related pathways are Leishmaniasis and Transcriptional misregulation in cancer. The compounds dl 111it and pga2 have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and testes, and related mouse phenotypes are renal/urinary system and craniofacial.

Wikipedia:66 Plasma cell leukemia (PCL), a lymphoproliferative disorder, is a rare cancer involving a subtype of... more...

Aliases & Classifications for Plasma Cell Leukemia

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44NIH Rare Diseases, 46Novoseek, 63UMLS, 26ICD10
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Related Diseases for Plasma Cell Leukemia

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18GeneCards, 19GeneDecks
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Diseases related to Plasma Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.8CD40, CDK4, CCND1, TP73
2multiple myeloma31.3CD40, CCND1, MAF
3t-cell leukemia30.1CDK4, CD40
4chronic lymphocytic leukemia30.1CD40, CDK4, CCND1
5myeloma10.9
6plasmacytoma10.4
7macroglobulinemia10.2
8amyloidosis10.2
9meningitis10.2
10myelofibrosis10.2
11osteosclerosis10.2
12hematopoietic stem cell transplantation10.2
13esophageal cancer10.1CCND1
14hepatitis c10.1
15acalculous cholecystitis10.1
16plasmacytic leukemia10.1
17measles10.1
18leukemoid reaction10.1
19serous cystadenocarcinoma10.1
20adult t-cell leukemia10.1
21ovarian serous cystadenocarcinoma10.1
22extramedullary plasmacytoma10.1
23cholecystitis10.1
24cranial nerve palsy10.1
25cystadenocarcinoma10.1
26disseminated intravascular coagulation10.1
27hepatitis10.1
28pancreatitis10.1
29paraplegia10.1
30pneumonia10.1
31proteinuria10.1
32restrictive cardiomyopathy10.1
33angioimmunoblastic t-cell lymphoma10.1
34chronic neutrophilic leukemia10.1
35splenomegaly10.1
36back pain10.1
37hepatitis c virus10.1
38sepsis10.1
39macroglobulinemia, waldenstrom, somatic10.0CD40, CCND1
40hairy cell leukemia10.0CD40, CCND1
41malt lymphoma10.0CD40, CCND1
42esophageal squamous cell carcinoma10.0CCND1, CDK4
43follicular lymphoma10.0CD40, CCND1
44b-cell chronic lymphocytic leukemia10.0CD40, CCND1
45burkitt's lymphoma10.0TP73, CCND1
46cervical squamous cell carcinoma10.0CD40, TP73
47laryngeal squamous cell carcinoma10.0TP73, CCND1
48pilocytic astrocytoma10.0TP73, CDK4
49breast cancer10.0CDK4, CCND1
50anaplastic astrocytoma10.0CDK4, TP73

Graphical network of the top 20 diseases related to Plasma Cell Leukemia:



Diseases related to plasma cell leukemia

Symptoms for Plasma Cell Leukemia

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Drugs & Therapeutics for Plasma Cell Leukemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Plasma Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Plasma Cell Leukemia

Search NIH Clinical Center for Plasma Cell Leukemia

Search CenterWatch for Plasma Cell Leukemia

Genetic Tests for Plasma Cell Leukemia

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Anatomical Context for Plasma Cell Leukemia

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34MalaCards
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MalaCards organs/tissues related to Plasma Cell Leukemia:

34
Bone marrow, Bone, Testes, T cells, Spleen, B cells, Skin, Breast, Liver, Atrioventricular node

Animal Models for Plasma Cell Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Plasma Cell Leukemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9CD40, CDK4, MAF
2MP:00053828.6TP73, CCND1, MAF
3MP:00020068.5CDK4, CCND1, TP73
4MP:00053918.2TP73, CCND1, MAF, CDK4
5MP:00053868.1TP73, CCND1, MAF, CDK4
6MP:00053978.1TP73, CCND1, CDK4, CD40
7MP:00053787.8CDK4, MAF, CCND1, TP73
8MP:00053877.8CD40, CDK4, MAF, CCND1, TP73
9MP:00036317.7TP73, CCND1, MAF, CDK4, CD40
10MP:00053767.7CD40, CDK4, MAF, CCND1, TP73

Publications for Plasma Cell Leukemia

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53PubMed
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Articles related to Plasma Cell Leukemia:

(show top 50)    (show all 311)
idTitleAuthorsYear
1
Lenalidomide and low-dose dexamethasone for newly diagnosed primary plasma cell leukemia. (23958922)
2014
2
Cell cycle genes co-expression in multiple myeloma and plasma cell leukemia. (23831116)
2013
3
Plasma cell leukemia masquerading as carcinocythemia. (24137759)
2013
4
Acquired del(9)(p22.3) in a primary plasma cell leukemia. (23985162)
2013
5
Secondary plasma cell leukemia. (23303035)
2012
6
Therapeutic effect of bortezomib for primary plasma cell leukemia followed by auto/allo stem cell transplantation. (23754921)
2012
7
Primary plasma cell leukemia followed by testicular plasmacytoma. (21229400)
2011
8
Splenic rupture in a plasma cell leukemia, mobilized with G-CSF for autologous stem cell transplant. (20818717)
2010
9
Prozone effect of serum IgE levels in a case of plasma cell leukemia. (20828419)
2010
10
A rare case of plasma cell leukemia in a 35 year old. (22885320)
2010
11
Primary plasma cell leukemia and autologous stem cell transplantation. (20442444)
2010
12
Frequent upregulation of MYC in plasma cell leukemia. (19396865)
2009
13
Plasma cell leukemia: a highly aggressive monoclonal gammopathy with a very poor prognosis. (19326058)
2009
14
Plasma cell leukemia with myelofibrosis. (19039200)
2008
15
Efficacy of bortezomib in combination chemotherapy on secondary plasma cell leukemia. (17613776)
2007
16
Thalidomide does not modify the prognosis of plasma cell leukemia patients: experience of a single center. (17325863)
2007
17
Bortezomib is effective in primary plasma cell leukemia. (16966282)
2006
18
Genomic aberrations in plasma cell leukemia shown by interphase fluorescence in situ hybridization. (15642395)
2005
19
Bortezomib is an efficient agent in plasma cell leukemias. (15609327)
2005
20
Plasma cell leukemia occurring in a patient with thrombocythemia treated with hydroxyurea and busulphan. (15160964)
2004
21
Cytogenetic and fluorescence in situ hybridization studies in 60 patients with multiple myeloma and plasma cell leukemia. (14697644)
2004
22
Primary plasma cell leukemia. (15645969)
2004
23
Thalidomide administration for the treatment of resistant plasma cell leukemia. (12747371)
2003
24
Long-term disease-free survival in a primary plasma cell leukemia treated by VAD, autologous PBSC transplantation, and IFN-alpha. (12221683)
2002
25
Intermediate doses of melphalan and dexamethasone are better than vincristine, adriamycin, and dexamethasone (VAD) and polychemotherapy for the treatment of primary plasma cell leukemia. (12185504)
2002
26
Long-lasting complete remission in plasma cell leukemia after aggressive chemotherapy and CD34-selected autologous peripheral blood progenitor cell transplant: molecular follow-up of minimal residual disease. (9827984)
1998
27
Plasma cell leukemia evolving into aggressive extramedullary plasmacytoma by clonal selection. (9256296)
1997
28
Non-random chromosomal rearrangements and their implications in clinical features and outcome of multiple myeloma and plasma cell leukemia. (8907265)
1996
29
Acute exacerbation of plasma cell leukemia associated with bacterial infection. (7604827)
1995
30
Analysis of the B-cell compartment in plasma cell leukemia and multiple myeloma: immunoglobulin gene rearrangement of EBV-infected B-cell lines. (7681918)
1993
31
The establishment of an interleukin-6-dependent myeloma cell line (FLAM-76) carrying t(11;14)(q13;q32) chromosome abnormality from an aggressive nonsecretory plasma cell leukemia. (1516003)
1992
32
Autologous bone marrow transplantation for plasma cell leukemia: report of a case. (1496648)
1992
33
Parasellar syndrome caused by plasma cell leukemia. (2624915)
1989
34
Plasma cell leukemia with an unusual karyotype and prolonged survival with oral alkylating agent therapy. (3680365)
1987
35
Cytoplasmic fibrils in plasma cell leukemia. (7223338)
1980
36
Synthesis of abnormal heavy chains in Bence-Jones plasma cell leukemia with intracellular IgG. (6777000)
1980
37
Transplantable murine plasma cell leukemia with polyclonal gammopathy. (6451145)
1980
38
Hyperviscosity syndrome in a patient with plasma cell leukemia. (119405)
1979
39
Plasma cell leukemia following treatment with radiotherapy and melphalan. (907952)
1977
40
Transmission and scanning electron microscopy study on plasma cell leukemia. (890142)
1977
41
Plasma cell leukemia with excretion of half-molecules of immunoglobulin A (alpha1 lambda1). (403845)
1977
42
Recovery from acute renal failure in plasma cell leukemia. (4127974)
1973
43
Ultrastructural aspects of bone marrow and peripheral blood cells in a case of plasma cell leukemia. (4996561)
1971
44
Plasma cell leukemia with IgD paraprotein. (4171442)
1968
45
Plasma cell leukemia in BALB-c mice inoculated with subcellular material. II. Serological changes. (4174912)
1968
46
Plasma cell leukemia and leukemoid reaction in multiple myeloma. (13953371)
1962
47
Acute plasma cell leukemia. (13559239)
1958
48
Subleukemic plasma cell leukemia. (14923071)
1952
49
Leukemic myelomatosis (plasma cell leukemia); a review with report of four cases. (14933193)
1952
50
Unusual remission after radiophosphorus therapy in a case of acute plasma cell leukemia. (18875364)
1948

Variations for Plasma Cell Leukemia

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Expression for genes affiliated with Plasma Cell Leukemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plasma Cell Leukemia

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Pathways for genes affiliated with Plasma Cell Leukemia

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51PathCards, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 55R&D Systems, 61Thomson Reuters, 58SinoBiological, 5Cell Signaling Technology
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Pathways related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CD40, MAF
29.5CD40, MAF
39.5MAF, CCND1
4
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.4MAF, CDK4
5
Show member pathways
9.3CCND1, CDK4
69.3CCND1, CDK4
7
Show member pathways
9.3CCND1, CDK4
8
Show member pathways
Cell cycle39
9.3CCND1, CDK4
99.3CDK4, CCND1
10
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.3CDK4, CCND1
11
Show member pathways
9.3CDK4, CCND1
12
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.3CDK4, CCND1
139.3CDK4, CCND1
149.3CDK4, CCND1
15
Show member pathways
9.3CDK4, CCND1
16
Show member pathways
9.3CDK4, CCND1
179.3CDK4, CCND1
189.3CDK4, CCND1
199.3CDK4, CCND1
209.3CDK4, CCND1
219.3CDK4, CCND1
22
Show member pathways
Cell cycle ESR1 regulation of G1 S transition61
Immune response MIF JAB1 signaling61
Cell cycle Cell cycle generic schema 61
9.3CDK4, CCND1
23
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation61
9.3CDK4, CCND1
24
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.1TP73, CCND1
259.1CCND1, TP73
26
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.8CD40, CDK4, CCND1
278.8CD40, CDK4, CCND1
28
Show member pathways
8.5TP73, CCND1, CDK4
29
Show member pathways
8.5TP73, CCND1, CDK4
308.5CDK4, CCND1, TP73
31
Show member pathways
DNA damage response39
8.5CDK4, CCND1, TP73

Compounds for genes affiliated with Plasma Cell Leukemia

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB, 62Tocris Bioscience, 52PharmGKB, 3BitterDB
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Compounds related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1dl 111it469.8CDK4, CCND1
2pga2469.8CCND1, CDK4
3berberine469.8CDK4, CCND1
4ag-126469.8CDK4, CCND1
5gossypol469.7CDK4, CCND1
6apigenin46 3010.7CDK4, CCND1
7olomoucine46 1210.7CCND1, CDK4
8lycopene46 2510.7CCND1, CDK4
9eb 108946 6210.7CDK4, CCND1
1017-(allylamino)-17-demethoxygeldanamycin469.7CDK4, CCND1
11indole-3-carbinol469.7CCND1, CDK4
12silymarin469.7CCND1, CDK4
13n-(4-hydroxyphenyl)retinamide469.6CDK4, CCND1
14roscovitine469.6CCND1, CDK4
15fludarabine46 52 1211.6CD40, CDK4
16flavopiridol46 1210.6CDK4, CCND1
17trastuzumab46 52 1211.6CCND1, CDK4
18gefitinib46 52 1211.5CDK4, CCND1
19progestin469.5CDK4, CCND1
20adpribose469.5CCND1, CDK4
21geldanamycin46 52 62 1212.4CDK4, CCND1
22lactacystin469.3CDK4, CCND1
23lovastatin46 52 62 30 1213.3CD40, CDK4, CCND1
24sp 60012546 6210.3CCND1, CDK4, CD40
25tacrolimus46 52 1211.2CCND1, CDK4, CD40
26n acetylcysteine469.2CCND1, CDK4, CD40
27sb 20358046 6210.2CD40, CDK4, CCND1
28butyrate469.2CCND1, CDK4, CD40
29paclitaxel46 52 1211.2CD40, CDK4, CCND1
30rapamycin469.2CD40, CDK4, CCND1
31pd 98,059469.2CD40, CDK4, CCND1
32ly294002469.2CD40, CDK4, CCND1
33glycogen46 2510.2CCND1, CDK4, CD40
34genistein46 30 62 3 25 1214.2CD40, CDK4, CCND1
35thymidine46 2510.1CD40, CDK4, CCND1
36cycloheximide469.1CD40, CDK4, CCND1
37steroid469.0CD40, CDK4, CCND1
38cisplatin46 52 62 1211.8CDK4, CCND1, TP73
39gemcitabine46 52 1210.8CCND1, TP73
40phosphatidylinositol468.8CCND1, CDK4, CD40
41arginine468.6CDK4, MAF, TP73
42doxorubicin46 52 1210.4CD40, CDK4, CCND1, TP73
43paraffin468.4TP73, CCND1, CDK4, CD40
44progesterone46 30 62 25 1212.4TP73, CCND1, CDK4, CD40
45oligonucleotide468.4CD40, CDK4, CCND1, TP73
46vegf468.4CD40, CDK4, CCND1, TP73
47threonine468.4TP73, CCND1, CDK4, CD40
48zinc46 259.4CD40, CDK4, TP73
49retinoic acid46 259.4CD40, CDK4, CCND1, TP73
50tyrosine468.3CD40, CDK4, CCND1, TP73

GO Terms for genes affiliated with Plasma Cell Leukemia

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17Gene Ontology
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Cellular components related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:0059239.3CDK4, CCND1
2cyclin-dependent protein kinase holoenzyme complexGO:0003079.0CDK4, CCND1
3chromatinGO:0007858.5CDK4, MAF, TP73

Biological processes related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of G2/M transition of mitotic cell cycleGO:0109719.6CDK4, CCND1
2negative regulation of cell cycle arrestGO:0711579.6CCND1, CDK4
3organ regenerationGO:0311009.5CDK4, CCND1
4cell divisionGO:0513019.4CDK4, CCND1
5mitotic G1 DNA damage checkpointGO:0315719.4CCND1, TP73
6positive regulation of protein phosphorylationGO:0019349.3CCND1, CD40
7response to organonitrogen compoundGO:0102439.3CCND1, TP73
8response to X-rayGO:0101659.3CCND1, TP73
9positive regulation of cell sizeGO:0457939.3CDK4, TP73
10cellular response to DNA damage stimulusGO:0069749.1CCND1, TP73
11G1/S transition of mitotic cell cycleGO:0000829.0CDK4, CCND1
12negative regulation of transcription from RNA polymerase II promoterGO:0001228.8TP73, CCND1, MAF
13positive regulation of transcription from RNA polymerase II promoterGO:0459448.7CD40, MAF, TP73

Molecular functions related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:0324039.3CDK4, CCND1

Products for genes affiliated with Plasma Cell Leukemia

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  • Antibodies
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Sources for Plasma Cell Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet