MCID: PLS016
MIFTS: 49

Plasma Cell Leukemia malady

Cancer category

Summaries for Plasma Cell Leukemia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Plasma cell leukemia (PCL), a lymphoproliferative disorder, is a rare cancer involving a subtype of... more...

MalaCards: Plasma Cell Leukemia, also known as leukemia, plasma cell, is related to t-cell leukemia and acute leukemia. An important gene associated with Plasma Cell Leukemia is MAF (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog), and among its related pathways are Cell cycle and DNA damage ATM/ATR regulation of G1/S checkpoint. The compounds cycloheximide and butyrate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotypes are vision/eye and renal/urinary system.

Aliases & Classifications for Plasma Cell Leukemia

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

plasma cell leukemia 43 45
leukemia, plasma cell 43 61


External Ids:

ICD1025 C90.1

Related Diseases for Plasma Cell Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Plasma Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1t-cell leukemia31.5CCND3, IRF4, CD40, CDK4
2acute leukemia30.8CSF1, NCAM1, KRAS
3measles30.0CSF1, CD40LG
4hepatitis c30.0ITGB1, CD40LG, KRAS
5testicular leukemia10.3
6macroglobulinemia10.2
7acute t cell leukemia10.2
8amyloidosis10.2
9hematopoietic stem cell transplantation10.2
10acalculous cholecystitis10.1
11leukemoid reaction10.1
12serous cystadenocarcinoma10.1
13ovarian serous cystadenocarcinoma10.1
14plasmacytic leukemia10.1
15subleukemic leukemia10.1
16hepatitis d10.1
17adult lymphoma10.1
18extramedullary plasmacytoma10.1
19t-cell large granular lymphocyte leukemia10.1
20chronic neutrophilic leukemia10.1
21leukemia, t-cell, chronic10.1
22large granular lymphocyte leukemia10.1
23splenomegaly10.1
24back pain10.1
25hepatitis c virus10.1
26sepsis10.1
27hepatoblastoma10.0NCAM1
28neuroblastoma10.0NCAM1
29nephrotic syndrome10.0ITGB1
30inflammatory bowel disease10.0IL6
31gastric lymphoma10.0BCL10
32galactosemia10.0IL6
33hypercalcemia10.0CSF1
34paraganglioma10.0NCAM1
35myopathy10.0NCAM1
36skin disease10.0IL6
37pheochromocytoma10.0NCAM1
38meningitis10.0IL6
39giant cell tumor10.0CSF1
40hepatitis b10.0KRAS
41neurofibromatosis10.0KRAS
42pilocytic astrocytoma10.0TP73, CDK4
43proteinuria10.0CD40LG
44monoclonal gammopathy of uncertain significance10.0FGFR3
45lupus erythematosus10.0CD40LG
46rhabdomyosarcoma10.0CDK4, NCAM1
47parathyroid adenoma10.0CCND1
48vascular disease10.0IL6
49pituitary tumors10.0NCAM1
50testicular cancer10.0KRAS

Graphical network of the top 20 diseases related to Plasma Cell Leukemia:



Diseases related to plasma cell leukemia

Clinical Features for Plasma Cell Leukemia

Drugs & Therapeutics for Plasma Cell Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Plasma Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Plasma Cell Leukemia

Search NIH Clinical Center for Plasma Cell Leukemia

Search CenterWatch for Plasma Cell Leukemia

Genetic Tests for Plasma Cell Leukemia

Anatomical Context for Plasma Cell Leukemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Plasma Cell Leukemia:

33
Bone marrow, Whole blood, Spleen, Liver, Breast, Skin, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Atrioventricular node

Animal Models for Plasma Cell Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Plasma Cell Leukemia:

37 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.4MAF, FGFR3
2MP:000536710.2FGFR3, MAF
3MP:000538010.0BCL10, ITGB1
4MP:00036319.6CSF1, MAF, CDK4, CD40LG, BCL10, TP73
5MP:00053959.4TP73, CD40LG, ITGB1, CSF1
6MP:00053908.9CCND1, CSF1, ITGB1, CD40, CD40LG, FGFR3
7MP:00053888.9CCND3, CCND1, ITGB1, FGFR3, IL6, KRAS
8MP:00053698.8BRAF, CSF1, ITGB1, CDKN2A, CDK4
9MP:00053828.8CCND1, BRAF, CSF1, ITGB1, MAF, FGFR3
10MP:00107718.6CCND1, ITGB1, NRAS, MAF, CDKN2A, CDK4
11MP:00053798.5CCND1, CSF1, ITGB1, CDKN2A, CDK4, CD40LG
12MP:00053898.5CCND1, BRAF, CSF1, ITGB1, CDKN2A, FGFR3
13MP:00053708.3CCND3, BRAF, CSF1, ITGB1, NRAS, CDKN2A
14MP:00028738.2CCND3, CCND1, BRAF, ITGB1, NRAS, CD40
15MP:00053818.2CCND1, BRAF, ITGB1, NRAS, CDKN2A, CDK4
16MP:00053768.1CCND3, CSF1, ITGB1, NRAS, IGHG1, MAF
17MP:00020067.9CCND3, CCND1, BRAF, NRAS, IGHG1, CDKN2A
18MP:00053857.9CCND3, CCND1, BRAF, CSF1, ITGB1, NRAS
19MP:00053867.6CCND3, CCND1, BRAF, CSF1, ITGB1, NCAM1
20MP:00053787.3NCAM1, ITGB1, CSF1, BRAF, CCND1, CCND3
21MP:00107686.4NRAS, NCAM1, ITGB1, CSF1, BRAF, CCND1
22MP:00053976.4CCND3, BCL10, KRAS, IL6, FGFR3, CD40LG
23MP:00053876.2CCND3, CCND1, TP73, BCL10, KRAS, IL6
24MP:00053846.2NRAS, NCAM1, ITGB1, IRF4, CSF1, BRAF

Publications for Plasma Cell Leukemia

Sources:
51PubMed
See all sources

Articles related to Plasma Cell Leukemia:

(show top 50)    (show all 378)
idTitleAuthorsYear
1
Induction of apoptosis in human myeloid leukemia cells by remote exposure of resistive barrier cold plasma. (24022746)
2014
2
Enrichment of IL-12-producing plasmacytoid dendritic cells in donor bone marrow grafts enhances graft-versus-leukemia activity in allogeneic hematopoietic stem cell transplantation. (23810844)
2013
3
Cell cycle genes co-expression in multiple myeloma and plasma cell leukemia. (23831116)
2013
4
Plasma cell leukemia. (23579759)
2013
5
Stringent complete remission of primary plasma cell leukemia with reduced-dose bortezomib, lenalidomide and dexamethasone: a case report and review of the literature. (23728562)
2013
6
Treatment with bortezomib-based regimens improves overall response and predicts for survival in patients with primary or secondary plasma cell leukemia: Analysis of the Greek myeloma study group. (24123068)
2013
7
Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia. (23037626)
2012
8
Frontline chemotherapy with bortezomib-containing combinations improves response rate and survival in primary plasma cell leukemia: a retrospective study from GIMEMA Multiple Myeloma Working Party. (22039089)
2012
9
Cytogenetic and therapeutic characterization of primary plasma cell leukemia: the IFM experience. (21799511)
2012
10
Primary plasma cell leukemia and autologous stem cell transplantation. (20442444)
2010
11
Primary plasma cell leukemia mimicking an adult T-cell leukemia-lymphoma: a case report. (20391976)
2010
12
Lenalidomide can induce graft versus leukemia effect in primary plasma cell leukemia: a case report. (19476997)
2009
13
Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose thalidomide maintenance therapy. (19834277)
2009
14
Genetic aberrations including chromosome 1 abnormalities and clinical features of plasma cell leukemia. (18676019)
2009
15
Response of primary plasma cell leukemia to the combination of bortezomib and dexamethasone: do specific cytogenetic and immunophenotypic characteristics influence treatment outcome? (18083228)
2008
16
Thirty patients with primary plasma cell leukemia: a single center experience. (18488157)
2008
17
Genetic aberrations and survival in plasma cell leukemia. (18216867)
2008
18
Reactive plasmacytoses can mimick plasma cell leukemia: therapeutical implications. (17325872)
2007
19
Successful treatment of multi-agent chemotherapy with rituximab for IgM plasma cell leukemia. (16540168)
2006
20
Tumor lysis syndrome after bortezomib therapy for plasma cell leukemia. (16305302)
2005
21
Plasma cell leukemia: case report of a rare and aggressive variant of multiple myeloma. (16304856)
2005
22
Plasma-cell leukemia and human herpesvirus 8 infection. (15385930)
2004
23
Long-term disease-free survival in a primary plasma cell leukemia treated by VAD, autologous PBSC transplantation, and IFN-alpha. (12221683)
2002
24
Intermediate doses of melphalan and dexamethasone are better than vincristine, adriamycin, and dexamethasone (VAD) and polychemotherapy for the treatment of primary plasma cell leukemia. (12185504)
2002
25
Primary plasma cell leukemia: clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics. (9920853)
1999
26
Biclonal primary plasma cell leukemia. (9714592)
1998
27
cCD79a expression in a case of plasma cell leukemia. (9680117)
1998
28
Plasmacytosis in acute myeloid leukemia: two cases of plasmacytosis and increased IL-6 production in the AML blast cells. (9692816)
1998
29
Molecular cytogenetic abnormalities in multiple myeloma and plasma cell leukemia measured using comparative genomic hybridization. (9172003)
1997
30
Plasma cell leukemia associated with monocytosis]. (9267165)
1997
31
Characterization of p16(INK4A) expression in multiple myeloma and plasma cell leukemia. (9815612)
1997
32
The establishment of an interleukin-6-dependent myeloma cell line (FLAM-76) carrying t(11;14)(q13;q32) chromosome abnormality from an aggressive nonsecretory plasma cell leukemia. (1516003)
1992
33
Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. (1715218)
1991
34
Similar cytogenetic abnormalities in two cases of plasma cell leukemia. (2009507)
1991
35
A patient with primary plasma cell leukemia accompanied by an extensive polypoid infiltration of the gastrointestinal tract. (1770327)
1991
36
Ring chromosomes in hypodiploid and hypotetraploid clones from an elderly patient with plasma cell leukemia. (2357687)
1990
37
Replication of measles virus in the human plasma cell leukemia-derived LICR-LON-HMy2 cell line. (2760166)
1989
38
Allogeneic bone marrow transplantation for plasma cell leukemia following melphalan, cyclophosphamide and total body irradiation. (2659119)
1989
39
Plasma cell leukemia with an unusual karyotype and prolonged survival following oral alkylating agent therapy. (3624303)
1987
40
Kappa-chain nephropathy associated with plasma cell leukemia. (6431919)
1984
41
IgD plasma cell leukemia and uterine malignant mixed MA1llerian tumor. (6433634)
1984
42
A human-hybridoma system based on a fast-growing mutant of the ARH-77 plasma cell leukemia-derived line. (7140810)
1982
43
Cytoplasmic fibrils in plasma cell leukemia. (7223338)
1980
44
Leukemic myelomatosis (plasma cell leukemia). (707428)
1978
45
Transmission and scanning electron microscopy study on plasma cell leukemia. (890142)
1977
46
Plasma cell leukemia. Report on 17 cases. (4821776)
1974
47
Leukemic form of immunocytic dyscrasia (plasma cell leukemia). A study of ten cases and a review of the literature. (4183356)
1969
48
Acute plasma cell leukemia. (13559239)
1958
49
An unusual case of acute plasma-cell leukemia treated with a folic acid antagonist and urethane. (14879373)
1951
50
Case of leukemic myelomatosis (plasma cell leukemia). (21013572)
1945

Genetic Variations for Plasma Cell Leukemia

Expression for genes affiliated with Plasma Cell Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Plasma Cell Leukemia

Search GEO for disease gene expression data for Plasma Cell Leukemia.

Pathways for genes affiliated with Plasma Cell Leukemia

Sources:
30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 54Reactome, 50PharmGKB, 53R&D Systems, 60Tocris Bioscience, 4Cell Signaling Technology
See all sources

Pathways related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CDKN2A
29.8CCND3, CCND1, CDK4
39.8CCND3, CCND1, CDK4
49.7CCND1, IL6, CCND3
5
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9.7KRAS, NRAS, FGFR3
6
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9.7BRAF, KRAS, NRAS
7
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9.7KRAS, NRAS, BRAF
8
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9.7BRAF, FGFR3, NRAS
9
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9.6MAF, CDK4, IRF4, CD40LG
10
Hide members
9.6CSF1, NRAS, CD40, FGFR3
119.6CCND1, CDK4, BRAF, KRAS
129.5KRAS, BRAF, CCND1, NRAS
13
Hide members
9.5KRAS, NRAS, BRAF, CCND1
149.5ITGB1, NCAM1, CD40LG, CD40
159.4CCND3, BCL10, CDK4, BRAF
16
Hide members
9.4CDK4, CDKN2A, CCND1, CCND3
17
Cell cycle Cell cycle (generic schema)
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9.4CDK4, CDKN2A, CCND3, CCND1
18
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9.4CDK4, CCND1, CCND3, CDKN2A
19
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9.4CDKN2A, CCND1, CCND3, TP73
20
Development Prolactin receptor signaling
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9.4CCND1, ITGB1, NRAS, KRAS
21
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9.4BRAF, KRAS, FGFR3, NRAS
22
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9.4CCND3, CDK4, IL6, TP73, CCND1
23
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9.4KRAS, IRF4, NCAM1, NRAS, IL6
24
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9.4CCND1, KRAS, IL6, BRAF, CDK4
25
Hide members
9.3FGFR3, ITGB1, NRAS, KRAS
26
Hide members
9.3IL6, ITGB1, MAF, CD40, CD40LG
279.3CDK4, NRAS, CCND1, BRAF, CDKN2A
28
Hide members
9.3KRAS, CD40, NRAS, BRAF, CD40LG
29
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9.3KRAS, CCND1, CDK4, IL6, CD40, NRAS
30
Hide members
9.3CCND1, TP73, CDK4, CCND3, CDKN2A
31
Hide members
9.3TP73, CDKN2A, CCND1, CCND3, CDK4
329.2KRAS, FGFR3, CDKN2A, NRAS, CCND1
33
Hide members
9.1TP73, KRAS, NRAS, ITGB1, BRAF
34
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9.1CCND1, BRAF, ITGB1, NRAS, KRAS
359.1CCND1, BRAF, ITGB1, KRAS, NRAS
36
Hide members
9.1BRAF, ITGB1, NRAS, FGFR3, IL6
37
Development Endothelin-1/EDNRA signaling
Hide members
9.1CCND3, CCND1, ITGB1, NRAS, KRAS
38
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9.0NRAS, BRAF, ITGB1, FGFR3, KRAS
39
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9.0ITGB1, BRAF, CCND1, CCND3, NRAS
40
Hide members
9.0NRAS, CDKN2A, CDK4, KRAS, CCND1, BRAF
419.0CCND3, KRAS, CDK4, CDKN2A, NRAS, CCND1
42
Hide members
8.9CD40LG, NRAS, IL6, IRF4, CDK4, KRAS
43
Hide members
8.8BRAF, ITGB1, NRAS, CDKN2A, FGFR3, IL6
44
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8.7BCL10, IL6, FGFR3, CDK4, NRAS, BRAF
45
Hide members
8.6IL6, CCND3, CSF1, ITGB1, NRAS, FGFR3
468.6IL6, CD40, CCND3, NRAS, CCND1, KRAS
478.2CSF1, CCND3, CCND1, ITGB1, NRAS, CDK4
488.2FGFR3, KRAS, IL6, CDK4, CDKN2A, NRAS
49
Hide members
8.1ITGB1, IRF4, NCAM1, NRAS, CD40LG, FGFR3
50
Hide members
7.8CDKN2A, CCND3, NRAS, ITGB1, FGFR3, IL6

Compounds for genes affiliated with Plasma Cell Leukemia

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5CCND3
2butyrate4510.5CD40, CSF1
3ivig4510.1CD40, CD40LG, CSF1
4fludarabine45 1110.8CD40, CCND3, CD40LG, CDK4
5neopterin459.8CSF1, CD40, CD40LG, IL6
6o6-methylguanine459.8CDKN2A, TP73, BRAF, KRAS
7rituximab45 50 1111.8CD40, CD40LG, IL6, CSF1
8crcs459.7CCND1, KRAS, CDKN2A, BRAF
9ionomycin459.7CSF1, BCL10, CD40, CDK4, CD40LG
10sp 60012545 6010.7ITGB1, CD40, CDK4, IL6, CCND1
11valine459.7KRAS, BRAF, CDKN2A, CDK4
12creatinine459.7NCAM1, MUC16, CSF1, CDKN2A
13melphalan45 1110.6IL6, FGFR3, MUC16, CCND1
14herbimycin a45 6010.6ITGB1, CD40LG, CD40, CDK4, IL6
15bortezomib45 1110.6CD40LG, CCND1, IL6, FGFR3
16ganglioside459.5ITGB1, NCAM1, CD40, CD40LG
17sb 20358045 6010.4CCND1, BRAF, ITGB1, CD40, CDK4, IL6
18actinomycin d459.4CDKN2A, CD40LG, TP73, IL6, CSF1, CD40
19methotrexate45 50 1111.4IL6, CD40, CCND3, CDKN2A, CCND1
20n acetylcysteine459.3IL6, CD40LG, CDK4, CD40, CDKN2A, CSF1
21wortmannin459.3ITGB1, KRAS, CSF1, BRAF, CCND1, CD40
22thalidomide45 50 60 1112.2CCND1, CD40LG, FGFR3, IL6
235fluorouracil459.2CDKN2A, CDK4, KRAS, TP73, CSF1
24agar459.2CCND1, NRAS, BRAF, CSF1, CDKN2A, CDK4
25dexamethasone45 50 29 1112.2ITGB1, MUC16, CDKN2A, CDK4, CD40LG, IL6
26thymidine45 2410.1IL6, CDK4, CD40, ITGB1, CSF1, CCND1
27imatinib45 50 1111.1CCND3, CCND1, TP73, KRAS, FGFR3, CSF1
2812-o-tetradecanoylphorbol 13-acetate459.1ITGB1, CDK4, NCAM1, CCND3, BRAF, CSF1
29ly294002459.0CDK4, IL6, CCND3, CCND1, BRAF, CSF1
30paclitaxel45 50 1111.0CSF1, BRAF, MUC16, CDKN2A, CCND1, CDK4
31rapamycin459.0BRAF, CCND1, CCND3, CSF1, CD40, KRAS
32genistein45 29 60 2 11 2414.0IL6, CDK4, CD40, ITGB1, CSF1, CCND1
33pd 98,059458.9CCND1, CCND3, IL6, CDK4, CD40, ITGB1
34testosterone45 60 11 2411.9IL6, CD40LG, CDK4, CDKN2A, NCAM1, CSF1
35serine458.8NCAM1, ITGB1, CSF1, CCND1, MUC16, FGFR3
36cysteine458.7CD40LG, CDK4, FGFR3, CDKN2A, NCAM1, ITGB1
37steroid458.7CCND3, CDK4, CD40, CDKN2A, MUC16, ITGB1
38threonine458.6BRAF, CDK4, CD40, CDKN2A, MUC16, NCAM1
39phosphatidylinositol458.6BRAF, KRAS, CDK4, CCND1, CD40, NCAM1
40alanine458.6BRAF, NCAM1, IL6, CD40LG, BCL10, CDK4
41arginine458.6CSF1, BRAF, CCND3, CDKN2A, CDK4, CD40LG
42oligonucleotide458.5TP73, KRAS, CDK4, CD40, CDKN2A, NRAS
43lipid458.4FGFR3, ITGB1, BRAF, TP73, NCAM1, CDKN2A
44cisplatin45 50 60 1111.2MUC16, CSF1, CDKN2A, CDK4, CD40LG, TP73
45doxorubicin45 50 1110.2CCND3, CCND1, CSF1, NCAM1, MUC16, CDKN2A
46progesterone45 60 29 11 2412.0NCAM1, CCND3, CCND1, BRAF, ITGB1, MUC16
47retinoic acid45 248.7KRAS, ITGB1, IL6, CD40LG, CDK4, CD40
48paraffin457.6CD40, CDK4, TP73, KRAS, FGFR3, CD40LG
49tyrosine457.4TP73, KRAS, IL6, CCND3, FGFR3, CDK4
50vegf457.4CDKN2A, CD40, CDK4, CD40LG, FGFR3, IL6

GO Terms for genes affiliated with Plasma Cell Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:00078510.0MAF, CDK4, TP73
2cyclin-dependent protein kinase holoenzyme complexGO:0003079.8CDK4, CCND1, CCND3
3external side of plasma membraneGO:0098979.2NCAM1, CD40, CD40LG, IL6, ITGB1
4plasma membraneGO:0058867.3FGFR3, BCL10, BRAF, CSF1, ITGB1, NCAM1

Biological processes related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell sizeGO:04579310.4CDK4, TP73
2regulation of immunoglobulin secretionGO:05102310.4CD40LG, CD40
3positive regulation of Rac protein signal transductionGO:03502210.4KRAS, NRAS
4mitotic G1 DNA damage checkpointGO:03157110.3TP73, CCND1
5positive regulation of endothelial cell apoptotic processGO:200035310.3CD40, CD40LG
6regulation of synaptic transmission, GABAergicGO:03222810.3NRAS, KRAS
7positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.2CD40, FGFR3
8positive regulation of cyclin-dependent protein kinase activityGO:04573710.2CCND3, CCND1
9striated muscle cell differentiationGO:05114610.2KRAS, NRAS
10activation of MAPKK activityGO:00018610.1KRAS, NRAS, BRAF
11cellular response to mechanical stimulusGO:07126010.1ITGB1, CD40, BCL10
12B cell proliferationGO:04210010.0CD40LG, CD40
13MAPK cascadeGO:00016510.0KRAS, FGFR3, NRAS
14positive regulation of NF-kappaB transcription factor activityGO:05109210.0BCL10, KRAS, IL6, CD40
15positive regulation of MAPK cascadeGO:0434109.9IL6, FGFR3, ITGB1
16Ras protein signal transductionGO:0072659.9KRAS, CDKN2A, NRAS
17positive regulation of protein phosphorylationGO:0019349.9KRAS, CD40, CCND1, CCND3
18cytokine-mediated signaling pathwayGO:0192219.9KRAS, IL6, NCAM1, IRF4
19Fc-epsilon receptor signaling pathwayGO:0380959.8NRAS, FGFR3, KRAS, BCL10
20negative regulation of neuron apoptotic processGO:0435249.8TP73, KRAS, NRAS
21inflammatory responseGO:0069549.8CSF1, CD40, CD40LG, IL6, TP73
22fibroblast growth factor receptor signaling pathwayGO:0085439.8BRAF, NRAS, FGFR3, KRAS
23positive regulation of apoptotic processGO:0430659.7ITGB1, CDK4, FGFR3, IL6, TP73
24response to drugGO:0424939.6CCND1, ITGB1, CDK4, IL6
25positive regulation of transcription, DNA-dependentGO:0458939.6IRF4, CDKN2A, IL6, BCL10, TP73
26positive regulation of ERK1 and ERK2 cascadeGO:0703749.6BRAF, FGFR3, IL6
27positive regulation of transcription from RNA polymerase II promoterGO:0459449.6IRF4, MAF, CDKN2A, CD40, IL6, TP73
28neurotrophin TRK receptor signaling pathwayGO:0480119.5BRAF, NRAS, FGFR3, KRAS
29regulation of immune responseGO:0507769.4ITGB1, CD40, CD40LG
30innate immune responseGO:0450879.2CSF1, NRAS, IGHG1, FGFR3, KRAS, BCL10
31positive regulation of cell proliferationGO:0082849.1KRAS, CSF1, ITGB1, NRAS, CDK4, FGFR3

Molecular functions related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:0081349.5CDKN2A, BCL10, TP73, IRF4
2protein kinase bindingGO:0199018.8CCND3, TP73, BCL10, CDKN2A, ITGB1, CCND1
3protein bindingGO:0055156.3CCND3, CCND1, BRAF, IRF4, ITGB1, BCL10

Products for genes affiliated with Plasma Cell Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Plasma Cell Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet