MCID: PLS016
MIFTS: 49

Plasma Cell Leukemia malady

Rare diseases, Cancer diseases categories
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Summaries for Plasma Cell Leukemia

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NIH Rare Diseases:42 Plasma cell leukemia (pcl) is a rare and aggressive form of multiple myeloma that involves high levels of plasma cells circulating in the peripheral blood. the signs and symptoms of pcl include aggressive clinical features, such as extramedullary disease, bone marrow failure, advanced stage disease and expression of distinct immunophenotypic markers. different types of treatments are available for patients with pcl. some treatments are standard (the currently used treatment), and some are being tested in clinical trials. for detailed information on the available treatment options, please visit the following link. http://www.cancer.gov/cancertopics/pdq/treatment/myeloma/patient/page4 last updated: 2/20/2014

MalaCards based summary: Plasma Cell Leukemia, also known as leukemia, plasma cell, is related to leukemia and multiple myeloma. An important gene associated with Plasma Cell Leukemia is MAF (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog), and among its related pathways are Leishmaniasis and Transcriptional misregulation in cancer. The compounds dl 111it and pga2 have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and testes, and related mouse phenotypes are renal/urinary system and craniofacial.

Wikipedia:65 Plasma cell leukemia (PCL), a lymphoproliferative disorder, is a rare cancer involving a subtype of... more...

Aliases & Classifications for Plasma Cell Leukemia

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS, 25ICD10
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Plasma Cell Leukemia, Aliases & Descriptions:

Name: Plasma Cell Leukemia 42 44
 
Leukemia, Plasma Cell 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

ICD1025 C90.1

Related Diseases for Plasma Cell Leukemia

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Diseases related to Plasma Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.4CD40, CDK4, CCND1, TP73
2multiple myeloma31.3CD40, CCND1, MAF
3chronic lymphocytic leukemia30.3CD40, CCND1
4t-cell leukemia30.1CDK4, CD40
5myeloma11.0
6plasmacytoma10.4
7esophageal cancer10.4CCND1
8hematopoietic stem cell transplantation10.2
9myelofibrosis10.2
10macroglobulinemia10.2
11amyloidosis10.2
12meningitis10.2
13osteosclerosis10.2
14macroglobulinemia, waldenstrom, somatic10.2CD40, CCND1
15hairy cell leukemia10.2CD40, CCND1
16malt lymphoma10.2CD40, CCND1
17esophageal squamous cell carcinoma10.2CCND1, CDK4
18follicular lymphoma10.2CD40, CCND1
19adult t-cell leukemia10.1
20hepatitis10.1
21hypertension10.1
22pulmonary hypertension10.1
23acalculous cholecystitis10.1
24hepatitis c10.1
25ovarian serous cystadenocarcinoma10.1
26plasmacytic leukemia10.1
27measles10.1
28leukemoid reaction10.1
29serous cystadenocarcinoma10.1
30extramedullary plasmacytoma10.1
31cholecystitis10.1
32cranial nerve palsy10.1
33cystadenocarcinoma10.1
34disseminated intravascular coagulation10.1
35pancreatitis10.1
36paraplegia10.1
37pneumonia10.1
38proteinuria10.1
39restrictive cardiomyopathy10.1
40angioimmunoblastic t-cell lymphoma10.1
41chronic neutrophilic leukemia10.1
42splenomegaly10.1
43back pain10.1
44hepatitis c virus10.1
45sepsis10.1
46burkitt's lymphoma10.1TP73, CCND1
47cervical squamous cell carcinoma10.1CD40, TP73
48laryngeal squamous cell carcinoma10.0TP73, CCND1
49pilocytic astrocytoma10.0TP73, CDK4
50breast cancer10.0CDK4, CCND1

Graphical network of the top 20 diseases related to Plasma Cell Leukemia:



Diseases related to plasma cell leukemia

Symptoms for Plasma Cell Leukemia

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Drugs & Therapeutics for Plasma Cell Leukemia

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Drug clinical trials:

Search ClinicalTrials for Plasma Cell Leukemia

Search NIH Clinical Center for Plasma Cell Leukemia

Genetic Tests for Plasma Cell Leukemia

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Anatomical Context for Plasma Cell Leukemia

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MalaCards organs/tissues related to Plasma Cell Leukemia:

32
Bone marrow, Bone, Testes, T cells, Spleen, Liver, Breast, Skin, B cells, Atrioventricular node

Animal Models for Plasma Cell Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Plasma Cell Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9CD40, CDK4, MAF
2MP:00053828.6TP73, CCND1, MAF
3MP:00020068.5CDK4, CCND1, TP73
4MP:00053918.2TP73, CCND1, MAF, CDK4
5MP:00053868.1TP73, CCND1, MAF, CDK4
6MP:00053978.1TP73, CCND1, CDK4, CD40
7MP:00053787.8CDK4, MAF, CCND1, TP73
8MP:00053877.8CD40, CDK4, MAF, CCND1, TP73
9MP:00036317.7TP73, CCND1, MAF, CDK4, CD40
10MP:00053767.7CD40, CDK4, MAF, CCND1, TP73

Publications for Plasma Cell Leukemia

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Articles related to Plasma Cell Leukemia:

(show top 50)    (show all 327)
idTitleAuthorsYear
1
Two cases of nonsecretory multiple myeloma presenting as primary plasma cell leukemia. (25224200)
2014
2
Plasma cell leukemia: a retrospective study of 10 cases. (24947090)
2014
3
A case of secondary plasma cell leukemia resistant to novel agents, in which stringent complete remission was achieved and maintained for a long period of time after VAD therapy and tandem autologous transplantation. (25337285)
2014
4
Lenalidomide (Revlimid), bortezomib (Velcade) and dexamethasone for the treatment of secondary plasma cell leukemia. (24884320)
2014
5
Lenalidomide and low-dose dexamethasone for newly diagnosed primary plasma cell leukemia. (23958922)
2014
6
Multiple myeloma patients with low proportion of circulating plasma cells had similar survival with primary plasma cell leukemia patients. (25231928)
2014
7
Plasma cell leukemia: three case-reports and review of literature. (24342791)
2013
8
Cell cycle genes co-expression in multiple myeloma and plasma cell leukemia. (23831116)
2013
9
Plasma cell leukemia masquerading as carcinocythemia. (24137759)
2013
10
Secondary plasma cell leukemia. (23303035)
2012
11
Primary plasma cell leukemia followed by testicular plasmacytoma. (21229400)
2011
12
Splenic rupture in a plasma cell leukemia, mobilized with G-CSF for autologous stem cell transplant. (20818717)
2010
13
Prozone effect of serum IgE levels in a case of plasma cell leukemia. (20828419)
2010
14
A rare case of plasma cell leukemia in a 35 year old. (22885320)
2010
15
Primary plasma cell leukemia and autologous stem cell transplantation. (20442444)
2010
16
Frequent upregulation of MYC in plasma cell leukemia. (19396865)
2009
17
Plasma cell leukemia with myelofibrosis. (19039200)
2008
18
Efficacy of bortezomib in combination chemotherapy on secondary plasma cell leukemia. (17613776)
2007
19
Thalidomide does not modify the prognosis of plasma cell leukemia patients: experience of a single center. (17325863)
2007
20
Bortezomib is effective in primary plasma cell leukemia. (16966282)
2006
21
Genomic aberrations in plasma cell leukemia shown by interphase fluorescence in situ hybridization. (15642395)
2005
22
Bortezomib is an efficient agent in plasma cell leukemias. (15609327)
2005
23
Plasma cell leukemia occurring in a patient with thrombocythemia treated with hydroxyurea and busulphan. (15160964)
2004
24
Cytogenetic and fluorescence in situ hybridization studies in 60 patients with multiple myeloma and plasma cell leukemia. (14697644)
2004
25
Primary plasma cell leukemia. (15645969)
2004
26
Thalidomide administration for the treatment of resistant plasma cell leukemia. (12747371)
2003
27
Long-term disease-free survival in a primary plasma cell leukemia treated by VAD, autologous PBSC transplantation, and IFN-alpha. (12221683)
2002
28
Intermediate doses of melphalan and dexamethasone are better than vincristine, adriamycin, and dexamethasone (VAD) and polychemotherapy for the treatment of primary plasma cell leukemia. (12185504)
2002
29
Long-lasting complete remission in plasma cell leukemia after aggressive chemotherapy and CD34-selected autologous peripheral blood progenitor cell transplant: molecular follow-up of minimal residual disease. (9827984)
1998
30
Plasma cell leukemia evolving into aggressive extramedullary plasmacytoma by clonal selection. (9256296)
1997
31
Non-random chromosomal rearrangements and their implications in clinical features and outcome of multiple myeloma and plasma cell leukemia. (8907265)
1996
32
Acute exacerbation of plasma cell leukemia associated with bacterial infection. (7604827)
1995
33
Analysis of the B-cell compartment in plasma cell leukemia and multiple myeloma: immunoglobulin gene rearrangement of EBV-infected B-cell lines. (7681918)
1993
34
The establishment of an interleukin-6-dependent myeloma cell line (FLAM-76) carrying t(11;14)(q13;q32) chromosome abnormality from an aggressive nonsecretory plasma cell leukemia. (1516003)
1992
35
Autologous bone marrow transplantation for plasma cell leukemia: report of a case. (1496648)
1992
36
Plasma cell leukemia with an unusual karyotype and prolonged survival with oral alkylating agent therapy. (3680365)
1987
37
Cytoplasmic fibrils in plasma cell leukemia. (7223338)
1980
38
Synthesis of abnormal heavy chains in Bence-Jones plasma cell leukemia with intracellular IgG. (6777000)
1980
39
Transplantable murine plasma cell leukemia with polyclonal gammopathy. (6451145)
1980
40
Hyperviscosity syndrome in a patient with plasma cell leukemia. (119405)
1979
41
Plasma cell leukemia following treatment with radiotherapy and melphalan. (907952)
1977
42
Transmission and scanning electron microscopy study on plasma cell leukemia. (890142)
1977
43
Plasma cell leukemia with excretion of half-molecules of immunoglobulin A (alpha1 lambda1). (403845)
1977
44
Recovery from acute renal failure in plasma cell leukemia. (4127974)
1973
45
Ultrastructural aspects of bone marrow and peripheral blood cells in a case of plasma cell leukemia. (4996561)
1971
46
Plasma cell leukemia with IgD paraprotein. (4171442)
1968
47
Plasma cell leukemia and leukemoid reaction in multiple myeloma. (13953371)
1962
48
Acute plasma cell leukemia. (13559239)
1958
49
Subleukemic plasma cell leukemia. (14923071)
1952
50
Leukemic myelomatosis (plasma cell leukemia); a review with report of four cases. (14933193)
1952

Variations for Plasma Cell Leukemia

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Expression for genes affiliated with Plasma Cell Leukemia

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Expression patterns in normal tissues for genes affiliated with Plasma Cell Leukemia

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Pathways for genes affiliated with Plasma Cell Leukemia

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Pathways related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CD40, MAF
29.5CD40, MAF
39.5MAF, CCND1
4
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.4MAF, CDK4
5
Show member pathways
9.3CCND1, CDK4
69.3CCND1, CDK4
7
Show member pathways
9.3CCND1, CDK4
8
Show member pathways
Cell cycle37
9.3CCND1, CDK4
99.3CDK4, CCND1
10
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.3CDK4, CCND1
11
Show member pathways
9.3CDK4, CCND1
12
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.3CDK4, CCND1
139.3CDK4, CCND1
149.3CDK4, CCND1
15
Show member pathways
9.3CDK4, CCND1
16
Show member pathways
9.3CDK4, CCND1
179.3CDK4, CCND1
189.3CDK4, CCND1
199.3CDK4, CCND1
209.3CDK4, CCND1
219.3CDK4, CCND1
22
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.3CDK4, CCND1
23
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.3CDK4, CCND1
24
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.1TP73, CCND1
259.1CCND1, TP73
26
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.8CD40, CDK4, CCND1
278.8CD40, CDK4, CCND1
28
Show member pathways
8.5TP73, CCND1, CDK4
29
Show member pathways
8.5TP73, CCND1, CDK4
308.5CDK4, CCND1, TP73
31
Show member pathways
DNA damage response37
8.5CDK4, CCND1, TP73

Compounds for genes affiliated with Plasma Cell Leukemia

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Compounds related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1dl 111it449.8CCND1, CDK4
2pga2449.8CCND1, CDK4
3ag-126449.8CDK4, CCND1
4berberine449.8CCND1, CDK4
5gossypol449.7CCND1, CDK4
6apigenin44 2810.7CDK4, CCND1
7olomoucine44 1110.7CDK4, CCND1
8lycopene44 2410.7CDK4, CCND1
9eb 108944 6110.7CCND1, CDK4
1017-(allylamino)-17-demethoxygeldanamycin449.7CDK4, CCND1
11indole-3-carbinol449.7CDK4, CCND1
12silymarin449.7CCND1, CDK4
13n-(4-hydroxyphenyl)retinamide449.6CCND1, CDK4
14roscovitine449.6CCND1, CDK4
15fludarabine44 50 1111.6CDK4, CD40
16flavopiridol44 1110.6CDK4, CCND1
17trastuzumab44 50 1111.6CDK4, CCND1
18gefitinib44 50 1111.5CDK4, CCND1
19progestin449.5CDK4, CCND1
20adpribose449.5CDK4, CCND1
21geldanamycin44 50 61 1112.4CDK4, CCND1
22lactacystin449.3CDK4, CCND1
23lovastatin44 50 61 28 1113.3CD40, CDK4, CCND1
24sp 60012544 6110.3CDK4, CCND1, CD40
25tacrolimus44 50 1111.2CDK4, CCND1, CD40
26n acetylcysteine449.2CDK4, CD40, CCND1
27sb 20358044 6110.2CD40, CDK4, CCND1
28butyrate449.2CD40, CDK4, CCND1
29paclitaxel44 50 1111.2CD40, CCND1, CDK4
30rapamycin449.2CDK4, CD40, CCND1
31pd 98,059449.2CD40, CDK4, CCND1
32ly294002449.2CCND1, CDK4, CD40
33glycogen44 2410.2CD40, CCND1, CDK4
34genistein44 28 61 2 24 1114.2CD40, CCND1, CDK4
35thymidine44 2410.1CDK4, CCND1, CD40
36cycloheximide449.1CD40, CDK4, CCND1
37steroid449.0CDK4, CCND1, CD40
38cisplatin44 50 61 1111.8TP73, CDK4, CCND1
39gemcitabine44 50 1110.8CCND1, TP73
40phosphatidylinositol448.8CCND1, CD40, CDK4
41arginine448.6MAF, CDK4, TP73
42doxorubicin44 50 1110.4TP73, CCND1, CDK4, CD40
43paraffin448.4CD40, CDK4, CCND1, TP73
44progesterone44 28 61 24 1112.4TP73, CCND1, CDK4, CD40
45oligonucleotide448.4TP73, CCND1, CD40, CDK4
46vegf448.4CD40, CDK4, TP73, CCND1
47threonine448.4TP73, CDK4, CD40, CCND1
48zinc44 249.4CD40, CDK4, TP73
49retinoic acid44 249.4CDK4, CCND1, TP73, CD40
50tyrosine448.3CCND1, CDK4, CD40, TP73

GO Terms for genes affiliated with Plasma Cell Leukemia

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Cellular components related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:0059239.3CDK4, CCND1
2cyclin-dependent protein kinase holoenzyme complexGO:0003079.0CDK4, CCND1
3chromatinGO:0007858.5CDK4, MAF, TP73

Biological processes related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of G2/M transition of mitotic cell cycleGO:0109719.6CDK4, CCND1
2negative regulation of cell cycle arrestGO:0711579.6CCND1, CDK4
3organ regenerationGO:0311009.5CDK4, CCND1
4cell divisionGO:0513019.4CDK4, CCND1
5mitotic G1 DNA damage checkpointGO:0315719.4CCND1, TP73
6positive regulation of protein phosphorylationGO:0019349.3CCND1, CD40
7response to organonitrogen compoundGO:0102439.3CCND1, TP73
8response to X-rayGO:0101659.3CCND1, TP73
9positive regulation of cell sizeGO:0457939.3CDK4, TP73
10cellular response to DNA damage stimulusGO:0069749.1CCND1, TP73
11G1/S transition of mitotic cell cycleGO:0000829.0CDK4, CCND1
12negative regulation of transcription from RNA polymerase II promoterGO:0001228.8TP73, CCND1, MAF
13positive regulation of transcription from RNA polymerase II promoterGO:0459448.7CD40, MAF, TP73

Molecular functions related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:0324039.3CDK4, CCND1

Products for genes affiliated with Plasma Cell Leukemia

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  • Antibodies
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Sources for Plasma Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet