MCID: PLS016
MIFTS: 42

Plasma Cell Leukemia malady

Cancer diseases category

Summaries for Plasma Cell Leukemia

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Plasma cell leukemia (pcl) is a rare and aggressive form of multiple myeloma that involves high levels of plasma cells circulating in the peripheral blood. the signs and symptoms of pcl include aggressive clinical features, such as extramedullary disease, bone marrow failure, advanced stage disease and expression of distinct immunophenotypic markers. different types of treatments are available for patients with pcl. some treatments are standard (the currently used treatment), and some are being tested in clinical trials. for detailed information on the available treatment options, please visit the following link. http://www.cancer.gov/cancertopics/pdq/treatment/myeloma/patient/page4 last updated: 2/20/2014

MalaCards: Plasma Cell Leukemia, also known as leukemia, plasma cell, is related to leukemia and myeloma. An important gene associated with Plasma Cell Leukemia is MAF (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog), and among its related pathways are Cell cycle and DNA damage ATM/ATR regulation of G1/S checkpoint. The compounds cycloheximide and butyrate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and testes, and related mouse phenotypes are vision/eye and renal/urinary system.

Wikipedia:63 Plasma cell leukemia (PCL), a lymphoproliferative disorder, is a rare cancer involving a subtype of... more...

Aliases & Classifications for Plasma Cell Leukemia

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42NIH Rare Diseases, 44Novoseek, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

plasma cell leukemia 42 44
leukemia, plasma cell 42 60


External Ids:

ICD1025 C90.1

Related Diseases for Plasma Cell Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Plasma Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.9CDKN2A, CD40, CDK4, CD40LG, FGFR3, IL6
2myeloma31.3CCND3, IL6, FGFR3, CD40LG, NCAM1, CD40
3multiple myeloma31.2IL6, CCND3, CCND1, NCAM1, FGFR3
4acute leukemia30.8KRAS, NCAM1, CSF1
5plasmacytoma30.5IL6, CD40, IRF4
6t-cell leukemia30.4CD40, IRF4, CCND3, CDK4
7meningitis30.3IL6
8proteinuria30.0CD40LG
9measles30.0CD40LG, CSF1
10hepatitis30.0CD40LG, KRAS
11pancreatitis30.0NRAS, IL6, KRAS
12hepatitis c30.0ITGB1, CD40LG, KRAS
13chronic lymphocytic leukemia30.0CCND1, CCND3, BCL10, CDK4, CD40LG, CD40
14testicular leukemia10.3
15macroglobulinemia10.2
16amyloidosis10.2
17myelofibrosis10.2
18osteosclerosis10.2
19acalculous cholecystitis10.0
20leukemoid reaction10.0
21serous cystadenocarcinoma10.0
22adult t-cell leukemia10.0
23ovarian serous cystadenocarcinoma10.0
24non-secretory myeloma10.0
25plasmacytic leukemia10.0
26subleukemic leukemia10.0
27adult lymphoma10.0
28extramedullary plasmacytoma10.0
29cholecystitis10.0
30cranial nerve palsy10.0
31cystadenocarcinoma10.0
32disseminated intravascular coagulation10.0
33hairy cell leukemia10.0
34lymphoblastic leukemia10.0
35ovarian cystadenocarcinoma10.0
36paraplegia10.0
37pneumonia10.0
38restrictive cardiomyopathy10.0
39hepatoblastoma10.0NCAM1
40neuroblastoma10.0NCAM1
41nephrotic syndrome10.0ITGB1
42inflammatory bowel disease10.0IL6
43gastric lymphoma10.0BCL10
44galactosemia10.0IL6
45hypercalcemia10.0CSF1
46paraganglioma10.0NCAM1
47myopathy10.0NCAM1
48skin disease10.0IL6
49pheochromocytoma10.0NCAM1
50giant cell tumor10.0CSF1

Graphical network of the top 20 diseases related to Plasma Cell Leukemia:



Diseases related to plasma cell leukemia

Clinical Features for Plasma Cell Leukemia

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Drugs & Therapeutics for Plasma Cell Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Plasma Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Plasma Cell Leukemia

Search NIH Clinical Center for Plasma Cell Leukemia

Search CenterWatch for Plasma Cell Leukemia

Genetic Tests for Plasma Cell Leukemia

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Anatomical Context for Plasma Cell Leukemia

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32MalaCards
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MalaCards organs/tissues related to Plasma Cell Leukemia:

32
Bone marrow, Bone, Testes

Animal Models for Plasma Cell Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Plasma Cell Leukemia:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.4MAF, FGFR3
2MP:000536710.2FGFR3, MAF
3MP:000538010.0BCL10, ITGB1
4MP:00036319.6CSF1, MAF, CDK4, CD40LG, BCL10, TP73
5MP:00053959.4TP73, CD40LG, ITGB1, CSF1
6MP:00053908.9CCND1, CSF1, ITGB1, CD40, CD40LG, FGFR3
7MP:00053888.9CCND3, CCND1, ITGB1, FGFR3, IL6, KRAS
8MP:00053698.8BRAF, CSF1, ITGB1, CDKN2A, CDK4
9MP:00053828.8CCND1, BRAF, CSF1, ITGB1, MAF, FGFR3
10MP:00107718.6CCND1, ITGB1, NRAS, MAF, CDKN2A, CDK4
11MP:00053798.5CCND1, CSF1, ITGB1, CDKN2A, CDK4, CD40LG
12MP:00053898.5CCND1, BRAF, CSF1, ITGB1, CDKN2A, FGFR3
13MP:00053708.3CCND3, BRAF, CSF1, ITGB1, NRAS, CDKN2A
14MP:00028738.2CCND3, CCND1, BRAF, ITGB1, NRAS, CD40
15MP:00053818.2CCND1, BRAF, ITGB1, NRAS, CDKN2A, CDK4
16MP:00053768.1CCND3, CSF1, ITGB1, NRAS, IGHG1, MAF
17MP:00020067.9CCND3, CCND1, BRAF, NRAS, IGHG1, CDKN2A
18MP:00053857.9CCND3, CCND1, BRAF, CSF1, ITGB1, NRAS
19MP:00053867.6CCND3, CCND1, BRAF, CSF1, ITGB1, NCAM1
20MP:00053787.3NCAM1, ITGB1, CSF1, BRAF, CCND1, CCND3
21MP:00107686.4NRAS, NCAM1, ITGB1, CSF1, BRAF, CCND1
22MP:00053976.4CCND3, BCL10, KRAS, IL6, FGFR3, CD40LG
23MP:00053876.2CCND3, CCND1, TP73, BCL10, KRAS, IL6
24MP:00053846.2NRAS, NCAM1, ITGB1, IRF4, CSF1, BRAF

Publications for Plasma Cell Leukemia

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Genetic Variations for Plasma Cell Leukemia

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Expression for genes affiliated with Plasma Cell Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plasma Cell Leukemia

Search GEO for disease gene expression data for Plasma Cell Leukemia.

Pathways for genes affiliated with Plasma Cell Leukemia

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Sources:
29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 53Reactome, 49PharmGKB, 52R&D Systems, 59Tocris Bioscience, 4Cell Signaling Technology
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Pathways related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2CDKN2A
29.8CCND3, CCND1, CDK4
39.8CCND3, CCND1, CDK4
49.7CCND1, IL6, CCND3
5
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9.7KRAS, NRAS, FGFR3
6
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9.7BRAF, KRAS, NRAS
7
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9.7KRAS, NRAS, BRAF
8
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9.7BRAF, FGFR3, NRAS
9
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9.6MAF, CDK4, IRF4, CD40LG
10
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9.6CSF1, NRAS, CD40, FGFR3
119.6CCND1, CDK4, BRAF, KRAS
129.5KRAS, BRAF, CCND1, NRAS
13
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9.5KRAS, NRAS, BRAF, CCND1
149.5ITGB1, NCAM1, CD40LG, CD40
159.4CCND3, BCL10, CDK4, BRAF
16
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9.4CDK4, CDKN2A, CCND1, CCND3
17
Cell cycle Cell cycle (generic schema)
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9.4CDK4, CDKN2A, CCND3, CCND1
18
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9.4CDK4, CCND1, CCND3, CDKN2A
19
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9.4CDKN2A, CCND1, CCND3, TP73
20
Development Prolactin receptor signaling
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9.4CCND1, ITGB1, NRAS, KRAS
21
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9.4BRAF, KRAS, FGFR3, NRAS
22
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9.4CCND3, CDK4, IL6, TP73, CCND1
23
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9.4KRAS, IRF4, NCAM1, NRAS, IL6
24
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9.4CCND1, KRAS, IL6, BRAF, CDK4
25
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9.3FGFR3, ITGB1, NRAS, KRAS
26
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9.3IL6, ITGB1, MAF, CD40, CD40LG
279.3CDK4, NRAS, CCND1, BRAF, CDKN2A
28
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9.3KRAS, CD40, NRAS, BRAF, CD40LG
29
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9.3KRAS, CCND1, CDK4, IL6, CD40, NRAS
30
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9.3CCND1, TP73, CDK4, CCND3, CDKN2A
31
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9.3TP73, CDKN2A, CCND1, CCND3, CDK4
329.2KRAS, FGFR3, CDKN2A, NRAS, CCND1
33
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9.1TP73, KRAS, NRAS, ITGB1, BRAF
34
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9.1CCND1, BRAF, ITGB1, NRAS, KRAS
359.1CCND1, BRAF, ITGB1, KRAS, NRAS
36
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9.1BRAF, ITGB1, NRAS, FGFR3, IL6
37
Development Endothelin-1/EDNRA signaling
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9.1CCND3, CCND1, ITGB1, NRAS, KRAS
38
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9.0NRAS, BRAF, ITGB1, FGFR3, KRAS
39
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9.0ITGB1, BRAF, CCND1, CCND3, NRAS
40
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9.0NRAS, CDKN2A, CDK4, KRAS, CCND1, BRAF
419.0CCND3, KRAS, CDK4, CDKN2A, NRAS, CCND1
42
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8.9CD40LG, NRAS, IL6, IRF4, CDK4, KRAS
43
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8.8BRAF, ITGB1, NRAS, CDKN2A, FGFR3, IL6
44
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8.7BCL10, IL6, FGFR3, CDK4, NRAS, BRAF
45
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8.6IL6, CCND3, CSF1, ITGB1, NRAS, FGFR3
468.6IL6, CD40, CCND3, NRAS, CCND1, KRAS
478.2CSF1, CCND3, CCND1, ITGB1, NRAS, CDK4
488.2FGFR3, KRAS, IL6, CDK4, CDKN2A, NRAS
49
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8.1ITGB1, IRF4, NCAM1, NRAS, CD40LG, FGFR3
50
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7.8CDKN2A, CCND3, NRAS, ITGB1, FGFR3, IL6

Compounds for genes affiliated with Plasma Cell Leukemia

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5CCND3
2butyrate4410.5CD40, CSF1
3ivig4410.1CD40, CD40LG, CSF1
4fludarabine44 1110.8CD40, CCND3, CD40LG, CDK4
5neopterin449.8CSF1, CD40, CD40LG, IL6
6o6-methylguanine449.8CDKN2A, TP73, BRAF, KRAS
7rituximab44 49 1111.8CD40, CD40LG, IL6, CSF1
8crcs449.7CCND1, KRAS, CDKN2A, BRAF
9ionomycin449.7CSF1, BCL10, CD40, CDK4, CD40LG
10sp 60012544 5910.7ITGB1, CD40, CDK4, IL6, CCND1
11valine449.7KRAS, BRAF, CDKN2A, CDK4
12creatinine449.7NCAM1, MUC16, CSF1, CDKN2A
13melphalan44 1110.6IL6, FGFR3, MUC16, CCND1
14herbimycin a44 5910.6ITGB1, CD40LG, CD40, CDK4, IL6
15bortezomib44 1110.6CD40LG, CCND1, IL6, FGFR3
16ganglioside449.5ITGB1, NCAM1, CD40, CD40LG
17sb 20358044 5910.4CCND1, BRAF, ITGB1, CD40, CDK4, IL6
18actinomycin d449.4CDKN2A, CD40LG, TP73, IL6, CSF1, CD40
19methotrexate44 49 1111.4IL6, CD40, CCND3, CDKN2A, CCND1
20n acetylcysteine449.3IL6, CD40LG, CDK4, CD40, CDKN2A, CSF1
21wortmannin449.3ITGB1, KRAS, CSF1, BRAF, CCND1, CD40
22thalidomide44 49 59 1112.2CCND1, CD40LG, FGFR3, IL6
235fluorouracil449.2CDKN2A, CDK4, KRAS, TP73, CSF1
24agar449.2CCND1, NRAS, BRAF, CSF1, CDKN2A, CDK4
25dexamethasone44 49 28 1112.2ITGB1, MUC16, CDKN2A, CDK4, CD40LG, IL6
26thymidine44 2410.1IL6, CDK4, CD40, ITGB1, CSF1, CCND1
27imatinib44 49 1111.1CCND3, CCND1, TP73, KRAS, FGFR3, CSF1
2812-o-tetradecanoylphorbol 13-acetate449.1ITGB1, CDK4, NCAM1, CCND3, BRAF, CSF1
29ly294002449.0CDK4, IL6, CCND3, CCND1, BRAF, CSF1
30paclitaxel44 49 1111.0CSF1, BRAF, MUC16, CDKN2A, CCND1, CDK4
31rapamycin449.0BRAF, CCND1, CCND3, CSF1, CD40, KRAS
32genistein44 28 59 2 11 2414.0IL6, CDK4, CD40, ITGB1, CSF1, CCND1
33pd 98,059448.9CCND1, CCND3, IL6, CDK4, CD40, ITGB1
34testosterone44 59 11 2411.9IL6, CD40LG, CDK4, CDKN2A, NCAM1, CSF1
35serine448.8NCAM1, ITGB1, CSF1, CCND1, MUC16, FGFR3
36cysteine448.7CD40LG, CDK4, FGFR3, CDKN2A, NCAM1, ITGB1
37steroid448.7CCND3, CDK4, CD40, CDKN2A, MUC16, ITGB1
38threonine448.6BRAF, CDK4, CD40, CDKN2A, MUC16, NCAM1
39phosphatidylinositol448.6BRAF, KRAS, CDK4, CCND1, CD40, NCAM1
40alanine448.6BRAF, NCAM1, IL6, CD40LG, BCL10, CDK4
41arginine448.6CSF1, BRAF, CCND3, CDKN2A, CDK4, CD40LG
42oligonucleotide448.5TP73, KRAS, CDK4, CD40, CDKN2A, NRAS
43lipid448.4FGFR3, ITGB1, BRAF, TP73, NCAM1, CDKN2A
44cisplatin44 49 59 1111.2MUC16, CSF1, CDKN2A, CDK4, CD40LG, TP73
45doxorubicin44 49 1110.2CCND3, CCND1, CSF1, NCAM1, MUC16, CDKN2A
46progesterone44 59 28 11 2412.0NCAM1, CCND3, CCND1, BRAF, ITGB1, MUC16
47retinoic acid44 248.7KRAS, ITGB1, IL6, CD40LG, CDK4, CD40
48paraffin447.6CD40, CDK4, TP73, KRAS, FGFR3, CD40LG
49tyrosine447.4TP73, KRAS, IL6, CCND3, FGFR3, CDK4
50vegf447.4CDKN2A, CD40, CDK4, CD40LG, FGFR3, IL6

GO Terms for genes affiliated with Plasma Cell Leukemia

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16Gene Ontology
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Cellular components related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:00078510.0TP73, CDK4, MAF
2cyclin-dependent protein kinase holoenzyme complexGO:0003079.8CDK4, CCND1, CCND3
3external side of plasma membraneGO:0098979.2ITGB1, NCAM1, CD40, CD40LG, IL6
4plasma membraneGO:0058867.3BRAF, CSF1, ITGB1, NCAM1, NRAS, MUC16

Biological processes related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell sizeGO:04579310.4CDK4, TP73
2regulation of immunoglobulin secretionGO:05102310.4CD40LG, CD40
3positive regulation of Rac protein signal transductionGO:03502210.4KRAS, NRAS
4mitotic G1 DNA damage checkpointGO:03157110.3TP73, CCND1
5positive regulation of endothelial cell apoptotic processGO:200035310.3CD40, CD40LG
6regulation of synaptic transmission, GABAergicGO:03222810.3NRAS, KRAS
7positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.2CD40, FGFR3
8positive regulation of cyclin-dependent protein kinase activityGO:04573710.2CCND3, CCND1
9striated muscle cell differentiationGO:05114610.2KRAS, NRAS
10activation of MAPKK activityGO:00018610.1KRAS, NRAS, BRAF
11cellular response to mechanical stimulusGO:07126010.1ITGB1, CD40, BCL10
12B cell proliferationGO:04210010.0CD40LG, CD40
13MAPK cascadeGO:00016510.0KRAS, FGFR3, NRAS
14positive regulation of NF-kappaB transcription factor activityGO:05109210.0BCL10, KRAS, IL6, CD40
15positive regulation of MAPK cascadeGO:0434109.9IL6, FGFR3, ITGB1
16Ras protein signal transductionGO:0072659.9KRAS, CDKN2A, NRAS
17positive regulation of protein phosphorylationGO:0019349.9KRAS, CD40, CCND1, CCND3
18cytokine-mediated signaling pathwayGO:0192219.9KRAS, IL6, NCAM1, IRF4
19Fc-epsilon receptor signaling pathwayGO:0380959.8NRAS, FGFR3, KRAS, BCL10
20negative regulation of neuron apoptotic processGO:0435249.8TP73, KRAS, NRAS
21inflammatory responseGO:0069549.8CSF1, CD40, CD40LG, IL6, TP73
22fibroblast growth factor receptor signaling pathwayGO:0085439.8BRAF, NRAS, FGFR3, KRAS
23positive regulation of apoptotic processGO:0430659.7ITGB1, CDK4, FGFR3, IL6, TP73
24response to drugGO:0424939.6CCND1, ITGB1, CDK4, IL6
25positive regulation of transcription, DNA-dependentGO:0458939.6IRF4, CDKN2A, IL6, BCL10, TP73
26positive regulation of ERK1 and ERK2 cascadeGO:0703749.6BRAF, FGFR3, IL6
27positive regulation of transcription from RNA polymerase II promoterGO:0459449.6IRF4, MAF, CDKN2A, CD40, IL6, TP73
28neurotrophin TRK receptor signaling pathwayGO:0480119.5BRAF, NRAS, FGFR3, KRAS
29regulation of immune responseGO:0507769.4ITGB1, CD40, CD40LG
30innate immune responseGO:0450879.2CSF1, NRAS, IGHG1, FGFR3, KRAS, BCL10
31positive regulation of cell proliferationGO:0082849.1KRAS, CSF1, ITGB1, NRAS, CDK4, FGFR3

Molecular functions related to Plasma Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:0081349.5TP73, BCL10, CDKN2A, IRF4
2protein kinase bindingGO:0199018.8TP73, BCL10, CDKN2A, ITGB1, CCND1, CCND3
3protein bindingGO:0055156.3IGHG1, ITGB1, IRF4, BRAF, CCND1, CCND3

Products for genes affiliated with Plasma Cell Leukemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Plasma Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet