Plasma Cell Neoplasm disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Plasma Cell Neoplasm

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⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Plasma cell dyscrasias are cancers of the plasma cells. Plasma cell dyscrasias are produced as a result... more...

MalaCards: Plasma Cell Neoplasm, also known as plasma cell dyscrasia, is related to plasmacytoma and leukemia. An important gene associated with Plasma Cell Neoplasm is PIGA (phosphatidylinositol glycan anchor biosynthesis, class A), and among its related pathways are Busulfan Pathway, Pharmacodynamics and IL6-mediated signaling events. The compounds cytidine and methylcellulose have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and bone marrow, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Plasma Cell Neoplasm

Sources:
⁸Disease Ontology, ⁶⁰UMLS, ⁵⁶SNOMED-CT, ³⁹NCIt, ³⁴MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases

Aliases & Descriptions:

plasma cell neoplasm ⁸ ⁶⁰

plasma cell dyscrasia ⁸ ⁶⁰

plasma cell tumour ⁸

plasmacytic tumor ⁸

External Ids:

Disease Ontology⁸ DOID:6536

NCIt³⁹ C4665

SNOMED-CT⁵⁶ 71390001, 277576009

MeSH³⁴ D010265

UMLS⁶⁰ C1136084

Related Diseases for Plasma Cell Neoplasm

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¹⁷GeneCards, ¹⁸GeneDecks
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Diseases related to Plasma Cell Neoplasm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 56)

id	Related Disease	Score	Top Affiliating Genes
1	plasmacytoma	30.4	AICDA, MYC, IL6
2	leukemia	30.0	PIGA, MYC, IL6, AICDA
3	polyneuropathy	10.6
4	amyloidosis	10.5
5	systemic mastocytosis	10.4
6	multiple myeloma	10.3
7	myeloma	10.3
8	pure red-cell aplasia	10.3
9	von willebrand's disease	10.3
10	fanconi syndrome	10.3
11	angiodysplasia	10.3
12	vitamin b12 deficiency	10.3
13	refractory plasma cell neoplasm	10.3
14	thyroiditis	10.2
15	polycythemia vera	10.2
16	cutis laxa	10.2
17	macroglobulinemia	10.2
18	factor x deficiency	10.2
19	smoldering myeloma	10.2
20	tuberculoid leprosy	10.2
21	osteoporosis	10.2
22	agammaglobulinemia	10.2
23	arthritis	10.2
24	demyelinating polyneuropathy	10.2
25	diabetes mellitus	10.2
26	hypertrichosis	10.2
27	interstitial nephritis	10.2
28	leprosy	10.2
29	mediastinitis	10.2
30	myelofibrosis	10.2
31	nephrotic syndrome	10.2
32	polycythemia	10.2
33	rheumatoid arthritis	10.2
34	scleroderma	10.2
35	stomatitis	10.2
36	ulcerative stomatitis	10.2
37	histiocytosis	10.0
38	conus medullaris neoplasm	10.0
39	bone lymphoma	10.0
40	composite lymphoma	10.0
41	extramedullary plasmacytoma	10.0
42	poems syndrome	10.0
43	conjunctivitis	10.0
44	heavy chain disease	10.0
45	neuropathy	10.0
46	peripheral neuropathy	10.0
47	proteinuria	10.0
48	plasma cell leukemia	10.0
49	extramedullary soft tissue plasmacytoma	10.0
50	primary plasmacytoma of the bone	10.0

Graphical network of the top 20 diseases related to Plasma Cell Neoplasm:

Clinical Features for Plasma Cell Neoplasm

Drugs & Therapeutics for Plasma Cell Neoplasm

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⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Plasma Cell Neoplasm

Anatomical Context for Plasma Cell Neoplasm

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³²MalaCards
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MalaCards organs/tissues related to Plasma Cell Neoplasm:

³²

Bone, B cells, Bone marrow, Thyroid, Nk cells

Animal Models for Plasma Cell Neoplasm or affiliated genes

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³⁶MGI
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MGI Mouse Phenotypes related to Plasma Cell Neoplasm:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary phenotype	MP:0005381	8.2	IL6, MYC, AICDA, PIGA
2	tumorigenesis	MP:0002006	7.9	PIGA, AICDA, MYC, IL6
3	integument phenotype	MP:0010771	7.5	IL6, MYC, AICDA, PIGA, CASP14

Publications for Plasma Cell Neoplasm

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⁵⁰PubMed
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Articles related to Plasma Cell Neoplasm:

(show all 42)

id	Title	Authors	Year
1	Epstein-Barr virus-driven bone marrow aplasia and plasmacytosis mimicking a plasma cell neoplasm. (24405048)	Desborough M.J.... Grech H.	2014
2	Practical diagnostic approaches to composite plasma cell neoplasm and low grade B-cell lymphoma/clonal infiltrates in the bone marrow. (24395190)	Hussein S.... Alobeid B.	2014
3	Dysmegakaryocytopoiesis and maintaining platelet count in patients with plasma cell neoplasm. (23814762)	Mair Y.... Cai D.	2013
4	Plasma cell neoplasm associated chronic neutrophilic leukemia with membrane proximal and truncating CSF3R mutations. (24033109)	Blombery P.... Khwaja A.	2013
5	Low levels of interleukin-1 receptor antagonist (IL-1RA) predict engraftment syndrome after autologous stem cell transplantation in POEMS syndrome and other plasma cell neoplasms. (23792270)	Keyzner A.... Dispenzieri A.	2013
6	Intracellular and extracellular immunoglobulin crystals assuming a multitude of geometric shapes in an IgG-I> plasma cell neoplasm. (23720061)	Srivastava S.... Ornstein D.L.	2013
7	CD3 expression in plasma cell neoplasm (multiple myeloma): a diagnostic pitfall. (23172088)	Tang Y.L.... Chuah K.L.	2012
8	Risk stratification of plasma cell neoplasm: insights from plasma cell-specific cytoplasmic immunoglobulin fluorescence in situ hybridization (cIg FISH) vs. conventional FISH. (22658896)	Dong H.... Chari A.	2012
9	Scleromyxoedema due to a plasma cell neoplasm: rapid remission with bortezomib, thalidomide and dexamethasone. (22429092)	Yeung C.K.... Kwong Y.L.	2012
10	Familial haemophagocytic lymphohistiocytosis-related plasma cell neoplasm: a case report. (22774220)	Pizzi M.... Pileri S.A.	2012
11	Lower incidence of plasma cell neoplasm is maintained in migrant Chinese to British Columbia: findings from a 30-year survey. (21851219)	Chan V.... Au W.Y.	2011
12	Plasma cell neoplasm in conjunction with glioblastoma of the conus medullaris. (21325257)	Williams S.R.... Parker J.C.	2011
13	Marginal zone B cell lymphomas with extensive plasmacytic differentiation are neoplasms of precursor plasma cells. (21337490)	Meyerson H.J.... Olobatuyi F.	2011
14	A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene. (20060400)	Araten D.J.... Sanders K.J.	2010
15	Mandibular radiolucency. Plasma cell neoplasm. (19906620)	Damm D.D.	2009
16	Ophthalmic presentation of plasma cell neoplasm. (19617795)	Person E.A.... Rupani M.K.	2009
17	Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. (17363561)	Qi C.F.... Morse H.C.	2007
18	Myc translocations in B cell and plasma cell neoplasms. (16815105)	Janz S.	2006
19	CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms. (16759389)	Han S.S.... Janz S.	2006
20	Clinical implication of centrosome amplification in plasma cell neoplasm. (16373658)	Chng W.J.... Fonseca R.	2006
21	Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. (15735016)	Park S.S.... Janz S.	2005
22	Expression of T/NK-cell and plasma cell antigens in nonhematopoietic epithelioid neoplasms. An immunohistochemical study of 447 cases. (12866374)	Chu P.G.... Weiss L.M.	2003
23	Multiple Endocrine Neoplasms in a Patient with AL Amyloidosis-Associated Plasma Cell Dyscrasia. (12114636)	Seki K.... Sano T.	1997
24	Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse. (3029337)	Nemni R.... Canal N.	1987
25	Treatment of plasma cell neoplasm with recombinant leukocyte A interferon and human lymphoblastoid interferon. (3917376)	Ohno R.... Morishima Y.	1985
26	Thyroid-gland plasma cell neoplasm (plasmacytoma). (7027992)	Macpherson T.A.... Kapadia S.B.	1981
27	An unusual case of a plasma cell neoplasm with an IgG3lambda myeloma and a gamma3 heavy chain disease protein. (412532)	Adlersberg J.B.... Franklin E.C.	1978
28	Plasma cell neoplasm involving the thyroid. (638958)	Shimaoka K.... Barcos M.	1978
29	Tumor cell invasion of hepatocytes in transplantable plasma cell neoplasm of mice. (4344454)	Sarkar K.	1972
30	Ploidy fluctuations of mouse plasma-cell neoplasm MSPC-1 during serial transplantation. (5157581)	Moriwaki K.... Yosida T.H.	1971
31	Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine. (4254308)	Everson R.... Hall T.C.	1970
32	Studies on the murine plasma-cell neoplasm, X5563. II. Accelerated immunologic reactivity to transplanted tumor induced in C3H mice by transferred immune rabbit cells. (6053557)	Gordon BL I.I.... Fong J.	1967
33	PLASMA CELL NEOPLASM ARISING IN A CAF MOUSE. CHARACTERISTICS AND RESPONSE TO CERTAIN CHEMOTHERAPEUTIC AGENTS. (14207853)	YANCEY S.T.	1964
34	BIOCHEMICAL EFFECTS OF DUAZOMYCIN A IN THE MOUSE PLASMA CELL NEOPLASM 70429. (14096421)	ANDERSON E.P.... Brockman R.W.	1963
35	Azaserine resistance in a plasma-cell neoplasm without change in active transport of the inhibitor. (13861221)	ANDERSON E.P.... JACQUEZ J.A.	1962
36	A study on globulin formation by plasma-cell neoplasm (5563) transplantable in mice. (13684805)	ASKONAS B.A.	1961
37	Distinctive myeloma globulins associated with a new plasma cell neoplasm of strain C3H mice. (13821296)	Fahey J.L.... Dunn T.B.	1960
38	Alterations of gamma globulin with plasma cell neoplasm in mice. (13675239)	COBAU C.D.... KORST D.R.	1959
39	Bence Jones proteinuria associated with a transplantable mouse plasma-cell neoplasm. (13821298)	Fahey J.L.... Potter M.	1959
40	Growth inhibition of homografts of a plasma-cell neoplasm in cell-impenetrable diffusion chambers placed in hyperimmunized mice. (13792639)	ALGIRE G.H.	1959
41	Studies of a plasma-cell neoplasm of the mouse. I. Characterization of neoplasm 70429, including its sensitivity to various antimetabolites with the rapid development of resistance to azaserine, DON, and N-methylformamide. (13406561)	Potter M.... Law L.W.	1957
42	Abnormal serum protein and bone destruction in transmissible mouse plasma cell neoplasm (multiple myeloma). (13408249)	Potter M.... PILGRIM H.I.	1957

Genes related to Plasma Cell Neoplasm

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Plasma Cell Neoplasm:

id	Symbol	Description	Score	Implication
1	PIGA	phosphatidylinositol glycan anchor biosynthesis, class A	21.70	GeneCards inferred : Publications, Disorders (show sections)
2	AICDA	activation-induced cytidine deaminase	18.37	GeneCards inferred : Publications, Disorders (show sections)
3	FMO4	flavin containing monooxygenase 4	15.03	GeneCards inferred : Publications, Disorders (show sections)
4	MYC	v-myc avian myelocytomatosis viral oncogene homolog	11.70	GeneCards inferred : Publications, Disorders (show sections)
5	IL6	interleukin 6 (interferon, beta 2)	8.37	GeneCards inferred : Publications, Disorders (show sections)
6	CASP14	caspase 14, apoptosis-related cysteine peptidase	5.03	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Plasma Cell Neoplasm disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	6	6	6
2	LSBio	-	-	6

Genetic Variations for Plasma Cell Neoplasm

Expression for genes affiliated with Plasma Cell Neoplasm

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plasma Cell Neoplasm

Search GEO for disease gene expression data for Plasma Cell Neoplasm.

Pathways for genes affiliated with Plasma Cell Neoplasm

Sources:
⁴⁹PharmGKB, ³⁷NCBI BioSystems Database, ⁵¹QIAGEN
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Pathways related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Busulfan Pathway, Pharmacodynamics⁴⁹	9.3	MYC, FMO4
2	IL6-mediated signaling events³⁷	9.0	IL6, MYC
3	TSLP Signaling Pathway³⁷	9.0	IL6, MYC
4	IL-10 Pathway⁵¹	9.0	IL6, MYC

Compounds for genes affiliated with Plasma Cell Neoplasm

Sources:
⁴⁴Novoseek, ¹¹DrugBank, ²⁴HMDB
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Compounds related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	cytidine⁴⁴ ¹¹ ²⁴	11.5	MYC, AICDA
2	methylcellulose⁴⁴	9.4	IL6, PIGA
3	ivig⁴⁴	9.3	AICDA, IL6
4	vesnarinone⁴⁴	9.2	IL6, MYC
5	2,5-oligoadenylate⁴⁴	9.2	IL6, MYC
6	melphalan⁴⁴ ¹¹	10.0	IL6, MYC
7	anisomycin⁴⁴ ¹¹	10.0	IL6, MYC
8	15-deoxy-delta-12,14-prostaglandin j2⁴⁴	8.9	IL6, MYC
9	bortezomib⁴⁴ ¹¹	9.7	IL6, MYC