Aliases & Classifications for Plasma Cell Neoplasm

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Plasma Cell Neoplasm, Aliases & Descriptions:

Name: Plasma Cell Neoplasm 9 60
Plasma Cell Dyscrasia 9 60
Plasma Cell Tumour 9
 
Plasmacytic Tumor 9
Multiple Myeloma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:6536
MeSH33 D010265
SNOMED-CT55 277576009, 71390001
NCIt38 C4665

Summaries for Plasma Cell Neoplasm

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MalaCards based summary: Plasma Cell Neoplasm, also known as plasma cell dyscrasia, is related to multiple myeloma and plasmacytoma. An important gene associated with Plasma Cell Neoplasm is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are Neural Crest Differentiation and Sorafenib Pharmacodynamics. The drugs carmustine and cisplatin and the compounds cytidine and ivig have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and bone marrow, and related mouse phenotypes are skeleton and tumorigenesis.

Related Diseases for Plasma Cell Neoplasm

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Graphical network of the top 20 diseases related to Plasma Cell Neoplasm:



Diseases related to plasma cell neoplasm

Symptoms for Plasma Cell Neoplasm

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Drugs & Therapeutics for Plasma Cell Neoplasm

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Genetic Tests for Plasma Cell Neoplasm

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Anatomical Context for Plasma Cell Neoplasm

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MalaCards organs/tissues related to Plasma Cell Neoplasm:

31
B cells, Bone, Bone marrow, Thyroid, Neutrophil

Animal Models for Plasma Cell Neoplasm or affiliated genes

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MGI Mouse Phenotypes related to Plasma Cell Neoplasm:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053907.8PIGA, MYC, IL6, FGFR3
2MP:00020067.8AICDA, PIGA, MYC, IL6, FGFR3
3MP:00053817.7FGFR3, IL6, MYC, PIGA, AICDA
4MP:00053977.7AICDA, PIGA, MYC, IL6, FGFR3
5MP:00107687.7FGFR3, IL6, MYC, PIGA, AICDA
6MP:00053847.6FGFR3, IL6, MYC, PIGA, AICDA
7MP:00107717.3FGFR3, CASP14, IL6, MYC, PIGA, AICDA

Publications for Plasma Cell Neoplasm

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Articles related to Plasma Cell Neoplasm:

(show all 44)
idTitleAuthorsYear
1
Pediatric Pharyngeal IgD-positive Monoclonal Plasmacytoid and Plasma Cell Neoplasm. (25851555)
2015
2
Osseous plasma cell neoplasm of the mandible for initial diagnosis of multiple myeloma: case report and literature review. (25861199)
2015
3
Crystal-storing histiocytosis with IgD I_-associated plasma cell neoplasm. (25028748)
2014
4
Classical Hodgkin lymphoma with coexistant plasma cell neoplasm: A case report. (25308039)
2014
5
Epstein-Barr virus-driven bone marrow aplasia and plasmacytosis mimicking a plasma cell neoplasm. (24405048)
2014
6
Image of the month : a rare presentation of a plasma cell neoplasm. (25333092)
2014
7
Nodal involvement of extranodal marginal zone lymphoma with extreme plasmacytic differentiation (Mott cell formation) simulating plasma cell neoplasm and lymphoplasmacytic lymphoma. (25548763)
2014
8
Practical diagnostic approaches to composite plasma cell neoplasm and low grade B-cell lymphoma/clonal infiltrates in the bone marrow. (24395190)
2014
9
Dysmegakaryocytopoiesis and maintaining platelet count in patients with plasma cell neoplasm. (23814762)
2013
10
Plasma cell neoplasm associated chronic neutrophilic leukemia with membrane proximal and truncating CSF3R mutations. (24033109)
2013
11
Low levels of interleukin-1 receptor antagonist (IL-1RA) predict engraftment syndrome after autologous stem cell transplantation in POEMS syndrome and other plasma cell neoplasms. (23792270)
2013
12
Intracellular and extracellular immunoglobulin crystals assuming a multitude of geometric shapes in an IgG-I> plasma cell neoplasm. (23720061)
2013
13
CD3 expression in plasma cell neoplasm (multiple myeloma): a diagnostic pitfall. (23172088)
2012
14
Risk stratification of plasma cell neoplasm: insights from plasma cell-specific cytoplasmic immunoglobulin fluorescence in situ hybridization (cIg FISH) vs. conventional FISH. (22658896)
2012
15
Scleromyxoedema due to a plasma cell neoplasm: rapid remission with bortezomib, thalidomide and dexamethasone. (22429092)
2012
16
Familial haemophagocytic lymphohistiocytosis-related plasma cell neoplasm: a case report. (22774220)
2012
17
Lower incidence of plasma cell neoplasm is maintained in migrant Chinese to British Columbia: findings from a 30-year survey. (21851219)
2011
18
Plasma cell neoplasm in conjunction with glioblastoma of the conus medullaris. (21325257)
2011
19
A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene. (20060400)
2010
20
Mandibular radiolucency. Plasma cell neoplasm. (19906620)
2009
21
Ophthalmic presentation of plasma cell neoplasm. (19617795)
2009
22
Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. (17363561)
2007
23
Myc translocations in B cell and plasma cell neoplasms. (16815105)
2006
24
CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms. (16759389)
2006
25
Clinical implication of centrosome amplification in plasma cell neoplasm. (16373658)
2006
26
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. (15735016)
2005
27
Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse. (3029337)
1987
28
Treatment of plasma cell neoplasm with recombinant leukocyte A interferon and human lymphoblastoid interferon. (3917376)
1985
29
Thyroid-gland plasma cell neoplasm (plasmacytoma). (7027992)
1981
30
An unusual case of a plasma cell neoplasm with an IgG3lambda myeloma and a gamma3 heavy chain disease protein. (412532)
1978
31
Plasma cell neoplasm involving the thyroid. (638958)
1978
32
Tumor cell invasion of hepatocytes in transplantable plasma cell neoplasm of mice. (4344454)
1972
33
Ploidy fluctuations of mouse plasma-cell neoplasm MSPC-1 during serial transplantation. (5157581)
1971
34
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine. (4254308)
1970
35
PLASMA CELL NEOPLASM ARISING IN A CAF MOUSE. CHARACTERISTICS AND RESPONSE TO CERTAIN CHEMOTHERAPEUTIC AGENTS. (14207853)
1964
36
BIOCHEMICAL EFFECTS OF DUAZOMYCIN A IN THE MOUSE PLASMA CELL NEOPLASM 70429. (14096421)
1963
37
Azaserine resistance in a plasma-cell neoplasm without change in active transport of the inhibitor. (13861221)
1962
38
A study on globulin formation by plasma-cell neoplasm (5563) transplantable in mice. (13684805)
1961
39
Distinctive myeloma globulins associated with a new plasma cell neoplasm of strain C3H mice. (13821296)
1960
40
Alterations of gamma globulin with plasma cell neoplasm in mice. (13675239)
1959
41
Bence Jones proteinuria associated with a transplantable mouse plasma-cell neoplasm. (13821298)
1959
42
Growth inhibition of homografts of a plasma-cell neoplasm in cell-impenetrable diffusion chambers placed in hyperimmunized mice. (13792639)
1959
43
Studies of a plasma-cell neoplasm of the mouse. I. Characterization of neoplasm 70429, including its sensitivity to various antimetabolites with the rapid development of resistance to azaserine, DON, and N-methylformamide. (13406561)
1957
44
Abnormal serum protein and bone destruction in transmissible mouse plasma cell neoplasm (multiple myeloma). (13408249)
1957

Variations for Plasma Cell Neoplasm

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Clinvar genetic disease variations for Plasma Cell Neoplasm:

6
id Gene Variation Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu)single nucleotide variantPathogenicrs78311289GRCh37Chr 4, 1807889: 1807889
2FGFR3NM_000142.4(FGFR3): c.742C> T (p.Arg248Cys)single nucleotide variantPathogenicrs121913482GRCh37Chr 4, 1803564: 1803564

Expression for genes affiliated with Plasma Cell Neoplasm

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Search GEO for disease gene expression data for Plasma Cell Neoplasm.

Pathways for genes affiliated with Plasma Cell Neoplasm

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Pathways related to Plasma Cell Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5FGFR3, MYC
2
Show member pathways
9.5FGFR3, MYC
39.5FGFR3, MYC
4
Show member pathways
Catalytic cycle of mammalian FMOs36
9.4FMO4, MYC
5
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.0IL6, MYC
69.0IL6, MYC
79.0IL6, MYC
89.0IL6, MYC
99.0IL6, MYC
109.0IL6, MYC
11
Show member pathways
8.7MYC, IL6, FGFR3
128.7MYC, IL6, FGFR3
13
Show member pathways
8.7FGFR3, IL6, MYC
148.7MYC, IL6, FGFR3
15
Show member pathways
8.7MYC, IL6, FGFR3
16
Show member pathways
8.7MYC, IL6, FGFR3

Compounds for genes affiliated with Plasma Cell Neoplasm

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Compounds related to Plasma Cell Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
idCompoundScoreTop Affiliating Genes
1cytidine43 24 1211.6MYC, AICDA
2ivig439.4AICDA, IL6
3thalidomide43 49 59 1212.4FGFR3, IL6
4methylcellulose439.4IL6, PIGA
5vesnarinone439.3IL6, MYC
62,5-oligoadenylate439.3MYC, IL6
715-deoxy-delta-12,14-prostaglandin j2439.2IL6, MYC
8anisomycin43 1210.2IL6, MYC
9prednisolone43 28 1211.0MYC, IL6
10hyaluronic acid43 2410.0IL6, MYC
11melphalan43 49 1211.0FGFR3, IL6, MYC
12bortezomib43 49 1211.0FGFR3, IL6, MYC
13cycloheximide438.8AICDA, MYC, IL6
14herbimycin a43 599.7IL6, MYC
15dexamethasone43 49 28 1211.7FGFR3, IL6, MYC
16vegf438.6FGFR3, IL6, MYC

GO Terms for genes affiliated with Plasma Cell Neoplasm

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Biological processes related to Plasma Cell Neoplasm according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.4FGFR3, IL6
2positive regulation of ERK1 and ERK2 cascadeGO:00703749.3FGFR3, IL6
3MAPK cascadeGO:00001659.2FGFR3, MYC
4positive regulation of MAPK cascadeGO:00434109.2FGFR3, IL6
5positive regulation of epithelial cell proliferationGO:00506799.0MYC, IL6
6positive regulation of cell proliferationGO:00082848.7FGFR3, IL6, MYC

Products for genes affiliated with Plasma Cell Neoplasm

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  • Antibodies
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  • Kits and Assays

Sources for Plasma Cell Neoplasm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet