MCID: PLS009
MIFTS: 40

Plasma Cell Neoplasm malady

Cancer diseases category

Summaries for Plasma Cell Neoplasm

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66Wikipedia, 34MalaCards
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Wikipedia:66 Plasma cell dyscrasias are cancers of the plasma cells. Plasma cell dyscrasias are produced as a result... more...

MalaCards: Plasma Cell Neoplasm, also known as plasma cell dyscrasia, is related to plasmacytoma and b-cell lymphomas. An important gene associated with Plasma Cell Neoplasm is FMO4 (flavin containing monooxygenase 4), and among its related pathways are Busulfan Pathway, Pharmacodynamics and Apoptosis and Autophagy. The compounds cytidine and ivig have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and bone marrow, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Plasma Cell Neoplasm

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9Disease Ontology, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

plasma cell neoplasm 9 63
plasma cell dyscrasia 9 63
plasma cell tumour 9
plasmacytic tumor 9


External Ids:

Disease Ontology9 DOID:6536
MeSH36 D010265
SNOMED-CT59 71390001, 277576009
NCIt41 C4665

Related Diseases for Plasma Cell Neoplasm

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Plasma Cell Neoplasm:



Diseases related to plasma cell neoplasm

Symptoms for Plasma Cell Neoplasm

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Drugs & Therapeutics for Plasma Cell Neoplasm

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Plasma Cell Neoplasm

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Anatomical Context for Plasma Cell Neoplasm

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34MalaCards
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MalaCards organs/tissues related to Plasma Cell Neoplasm:

34
Bone, B cells, Bone marrow, Thyroid

Animal Models for Plasma Cell Neoplasm or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Plasma Cell Neoplasm:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1PIGA, MYC, IL6, AICDA
2MP:00053848.1AICDA, PIGA, MYC, IL6
3MP:00053818.0AICDA, PIGA, MYC, IL6
4MP:00053977.8AICDA, PIGA, MYC, IL6
5MP:00107717.6MYC, AICDA, PIGA, IL6, CASP14

Publications for Plasma Cell Neoplasm

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53PubMed
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Articles related to Plasma Cell Neoplasm:

(show all 39)
idTitleAuthorsYear
1
Epstein-Barr virus-driven bone marrow aplasia and plasmacytosis mimicking a plasma cell neoplasm. (24405048)
2014
2
Practical diagnostic approaches to composite plasma cell neoplasm and low grade B-cell lymphoma/clonal infiltrates in the bone marrow. (24395190)
2014
3
Dysmegakaryocytopoiesis and maintaining platelet count in patients with plasma cell neoplasm. (23814762)
2013
4
Plasma cell neoplasm associated chronic neutrophilic leukemia with membrane proximal and truncating CSF3R mutations. (24033109)
2013
5
Low levels of interleukin-1 receptor antagonist (IL-1RA) predict engraftment syndrome after autologous stem cell transplantation in POEMS syndrome and other plasma cell neoplasms. (23792270)
2013
6
Intracellular and extracellular immunoglobulin crystals assuming a multitude of geometric shapes in an IgG-I> plasma cell neoplasm. (23720061)
2013
7
CD3 expression in plasma cell neoplasm (multiple myeloma): a diagnostic pitfall. (23172088)
2012
8
Risk stratification of plasma cell neoplasm: insights from plasma cell-specific cytoplasmic immunoglobulin fluorescence in situ hybridization (cIg FISH) vs. conventional FISH. (22658896)
2012
9
Scleromyxoedema due to a plasma cell neoplasm: rapid remission with bortezomib, thalidomide and dexamethasone. (22429092)
2012
10
Familial haemophagocytic lymphohistiocytosis-related plasma cell neoplasm: a case report. (22774220)
2012
11
Lower incidence of plasma cell neoplasm is maintained in migrant Chinese to British Columbia: findings from a 30-year survey. (21851219)
2011
12
Plasma cell neoplasm in conjunction with glioblastoma of the conus medullaris. (21325257)
2011
13
A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene. (20060400)
2010
14
Mandibular radiolucency. Plasma cell neoplasm. (19906620)
2009
15
Ophthalmic presentation of plasma cell neoplasm. (19617795)
2009
16
Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. (17363561)
2007
17
Myc translocations in B cell and plasma cell neoplasms. (16815105)
2006
18
CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms. (16759389)
2006
19
Clinical implication of centrosome amplification in plasma cell neoplasm. (16373658)
2006
20
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. (15735016)
2005
21
Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse. (3029337)
1987
22
Treatment of plasma cell neoplasm with recombinant leukocyte A interferon and human lymphoblastoid interferon. (3917376)
1985
23
Thyroid-gland plasma cell neoplasm (plasmacytoma). (7027992)
1981
24
An unusual case of a plasma cell neoplasm with an IgG3lambda myeloma and a gamma3 heavy chain disease protein. (412532)
1978
25
Plasma cell neoplasm involving the thyroid. (638958)
1978
26
Tumor cell invasion of hepatocytes in transplantable plasma cell neoplasm of mice. (4344454)
1972
27
Ploidy fluctuations of mouse plasma-cell neoplasm MSPC-1 during serial transplantation. (5157581)
1971
28
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine. (4254308)
1970
29
Studies on the murine plasma-cell neoplasm, X5563. II. Accelerated immunologic reactivity to transplanted tumor induced in C3H mice by transferred immune rabbit cells. (6053557)
1967
30
PLASMA CELL NEOPLASM ARISING IN A CAF MOUSE. CHARACTERISTICS AND RESPONSE TO CERTAIN CHEMOTHERAPEUTIC AGENTS. (14207853)
1964
31
BIOCHEMICAL EFFECTS OF DUAZOMYCIN A IN THE MOUSE PLASMA CELL NEOPLASM 70429. (14096421)
1963
32
Azaserine resistance in a plasma-cell neoplasm without change in active transport of the inhibitor. (13861221)
1962
33
A study on globulin formation by plasma-cell neoplasm (5563) transplantable in mice. (13684805)
1961
34
Distinctive myeloma globulins associated with a new plasma cell neoplasm of strain C3H mice. (13821296)
1960
35
Alterations of gamma globulin with plasma cell neoplasm in mice. (13675239)
1959
36
Bence Jones proteinuria associated with a transplantable mouse plasma-cell neoplasm. (13821298)
1959
37
Growth inhibition of homografts of a plasma-cell neoplasm in cell-impenetrable diffusion chambers placed in hyperimmunized mice. (13792639)
1959
38
Studies of a plasma-cell neoplasm of the mouse. I. Characterization of neoplasm 70429, including its sensitivity to various antimetabolites with the rapid development of resistance to azaserine, DON, and N-methylformamide. (13406561)
1957
39
Abnormal serum protein and bone destruction in transmissible mouse plasma cell neoplasm (multiple myeloma). (13408249)
1957

Variations for Plasma Cell Neoplasm

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Expression for genes affiliated with Plasma Cell Neoplasm

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plasma Cell Neoplasm

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Pathways for genes affiliated with Plasma Cell Neoplasm

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51PathCards, 52PharmGKB, 39NCBI BioSystems Database, 56Reactome, 5Cell Signaling Technology, 31KEGG, 54QIAGEN, 55R&D Systems, 61Thomson Reuters
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Pathways related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Catalytic cycle of mammalian FMOs39
9.4FMO4, MYC
29.3MYC, CASP14
3
Show member pathways
9.2IL6, AICDA
4
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.0IL6, MYC
5
Show member pathways
Type III interferon signaling39
9.0IL6, MYC
69.0IL6, MYC
7
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.0IL6, MYC
89.0IL6, MYC
99.0MYC, IL6
109.0IL6, MYC
119.0IL6, MYC
129.0MYC, IL6

Compounds for genes affiliated with Plasma Cell Neoplasm

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46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1cytidine46 25 1211.7MYC, AICDA
2ivig469.5AICDA, IL6
3methylcellulose469.4IL6, PIGA
4vesnarinone469.3IL6, MYC
52,5-oligoadenylate469.3IL6, MYC
6melphalan46 52 1211.3IL6, MYC
715-deoxy-delta-12,14-prostaglandin j2469.3IL6, MYC
8bortezomib46 52 1211.2MYC, IL6
9anisomycin46 1210.2IL6, MYC
10prednisolone46 30 1211.2IL6, MYC
11herbimycin a46 6210.1MYC, IL6
12hyaluronic acid46 2510.1IL6, MYC
13calcitriol46 62 25 1212.0IL6, MYC
14cycloheximide468.8IL6, MYC, AICDA
15curcumin468.7IL6, MYC
16estrogen468.6AICDA, MYC, IL6
17retinoic acid46 259.4CASP14, IL6, MYC

GO Terms for genes affiliated with Plasma Cell Neoplasm

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17Gene Ontology
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Biological processes related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of epithelial cell proliferationGO:0506799.0IL6, MYC

Products for genes affiliated with Plasma Cell Neoplasm

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  • Antibodies
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Sources for Plasma Cell Neoplasm

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet