MCID: PLS009
MIFTS: 44

Plasma Cell Neoplasm malady

Cancer diseases category

Summaries for Plasma Cell Neoplasm

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MalaCards based summary: Plasma Cell Neoplasm, also known as plasma cell dyscrasia, is related to plasmacytoma and b-cell lymphomas. An important gene associated with Plasma Cell Neoplasm is FMO4 (flavin containing monooxygenase 4), and among its related pathways are Busulfan Pathway, Pharmacodynamics and Apoptosis and Autophagy. The drugs cyclophosphamide and thalidomide and the compounds cytidine and ivig have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and bone marrow, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Plasma Cell Neoplasm

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Plasma Cell Neoplasm, Aliases & Descriptions:

Name: Plasma Cell Neoplasm 10 62
Plasma Cell Dyscrasia 10 62
 
Plasma Cell Tumour 10
Plasmacytic Tumor 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology10 DOID:6536
MeSH35 D010265
SNOMED-CT57 277576009, 71390001
NCIt40 C4665

Related Diseases for Plasma Cell Neoplasm

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Graphical network of the top 20 diseases related to Plasma Cell Neoplasm:



Diseases related to plasma cell neoplasm

Symptoms for Plasma Cell Neoplasm

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Drugs & Therapeutics for Plasma Cell Neoplasm

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Genetic Tests for Plasma Cell Neoplasm

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Anatomical Context for Plasma Cell Neoplasm

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MalaCards organs/tissues related to Plasma Cell Neoplasm:

33
B cells, Bone, Bone marrow, Thyroid, Neutrophil

Animal Models for Plasma Cell Neoplasm or affiliated genes

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MGI Mouse Phenotypes related to Plasma Cell Neoplasm:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1AICDA, PIGA, MYC, IL6
2MP:00053848.1IL6, MYC, PIGA, AICDA
3MP:00053818.0AICDA, PIGA, MYC, IL6
4MP:00053977.8AICDA, PIGA, MYC, IL6
5MP:00107717.6CASP14, IL6, MYC, PIGA, AICDA

Publications for Plasma Cell Neoplasm

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Articles related to Plasma Cell Neoplasm:

(show all 44)
idTitleAuthorsYear
1
Pediatric Pharyngeal IgD-positive Monoclonal Plasmacytoid and Plasma Cell Neoplasm. (25851555)
2015
2
Osseous plasma cell neoplasm of the mandible for initial diagnosis of multiple myeloma: case report and literature review. (25861199)
2015
3
Crystal-storing histiocytosis with IgD I_-associated plasma cell neoplasm. (25028748)
2014
4
Classical Hodgkin lymphoma with coexistant plasma cell neoplasm: A case report. (25308039)
2014
5
Epstein-Barr virus-driven bone marrow aplasia and plasmacytosis mimicking a plasma cell neoplasm. (24405048)
2014
6
Image of the month : a rare presentation of a plasma cell neoplasm. (25333092)
2014
7
Nodal involvement of extranodal marginal zone lymphoma with extreme plasmacytic differentiation (Mott cell formation) simulating plasma cell neoplasm and lymphoplasmacytic lymphoma. (25548763)
2014
8
Practical diagnostic approaches to composite plasma cell neoplasm and low grade B-cell lymphoma/clonal infiltrates in the bone marrow. (24395190)
2014
9
Dysmegakaryocytopoiesis and maintaining platelet count in patients with plasma cell neoplasm. (23814762)
2013
10
Plasma cell neoplasm associated chronic neutrophilic leukemia with membrane proximal and truncating CSF3R mutations. (24033109)
2013
11
Low levels of interleukin-1 receptor antagonist (IL-1RA) predict engraftment syndrome after autologous stem cell transplantation in POEMS syndrome and other plasma cell neoplasms. (23792270)
2013
12
Intracellular and extracellular immunoglobulin crystals assuming a multitude of geometric shapes in an IgG-I> plasma cell neoplasm. (23720061)
2013
13
CD3 expression in plasma cell neoplasm (multiple myeloma): a diagnostic pitfall. (23172088)
2012
14
Risk stratification of plasma cell neoplasm: insights from plasma cell-specific cytoplasmic immunoglobulin fluorescence in situ hybridization (cIg FISH) vs. conventional FISH. (22658896)
2012
15
Scleromyxoedema due to a plasma cell neoplasm: rapid remission with bortezomib, thalidomide and dexamethasone. (22429092)
2012
16
Familial haemophagocytic lymphohistiocytosis-related plasma cell neoplasm: a case report. (22774220)
2012
17
Lower incidence of plasma cell neoplasm is maintained in migrant Chinese to British Columbia: findings from a 30-year survey. (21851219)
2011
18
Plasma cell neoplasm in conjunction with glioblastoma of the conus medullaris. (21325257)
2011
19
A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene. (20060400)
2010
20
Mandibular radiolucency. Plasma cell neoplasm. (19906620)
2009
21
Ophthalmic presentation of plasma cell neoplasm. (19617795)
2009
22
Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. (17363561)
2007
23
Myc translocations in B cell and plasma cell neoplasms. (16815105)
2006
24
CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms. (16759389)
2006
25
Clinical implication of centrosome amplification in plasma cell neoplasm. (16373658)
2006
26
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. (15735016)
2005
27
Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse. (3029337)
1987
28
Treatment of plasma cell neoplasm with recombinant leukocyte A interferon and human lymphoblastoid interferon. (3917376)
1985
29
Thyroid-gland plasma cell neoplasm (plasmacytoma). (7027992)
1981
30
An unusual case of a plasma cell neoplasm with an IgG3lambda myeloma and a gamma3 heavy chain disease protein. (412532)
1978
31
Plasma cell neoplasm involving the thyroid. (638958)
1978
32
Tumor cell invasion of hepatocytes in transplantable plasma cell neoplasm of mice. (4344454)
1972
33
Ploidy fluctuations of mouse plasma-cell neoplasm MSPC-1 during serial transplantation. (5157581)
1971
34
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine. (4254308)
1970
35
PLASMA CELL NEOPLASM ARISING IN A CAF MOUSE. CHARACTERISTICS AND RESPONSE TO CERTAIN CHEMOTHERAPEUTIC AGENTS. (14207853)
1964
36
BIOCHEMICAL EFFECTS OF DUAZOMYCIN A IN THE MOUSE PLASMA CELL NEOPLASM 70429. (14096421)
1963
37
Azaserine resistance in a plasma-cell neoplasm without change in active transport of the inhibitor. (13861221)
1962
38
A study on globulin formation by plasma-cell neoplasm (5563) transplantable in mice. (13684805)
1961
39
Distinctive myeloma globulins associated with a new plasma cell neoplasm of strain C3H mice. (13821296)
1960
40
Alterations of gamma globulin with plasma cell neoplasm in mice. (13675239)
1959
41
Bence Jones proteinuria associated with a transplantable mouse plasma-cell neoplasm. (13821298)
1959
42
Growth inhibition of homografts of a plasma-cell neoplasm in cell-impenetrable diffusion chambers placed in hyperimmunized mice. (13792639)
1959
43
Studies of a plasma-cell neoplasm of the mouse. I. Characterization of neoplasm 70429, including its sensitivity to various antimetabolites with the rapid development of resistance to azaserine, DON, and N-methylformamide. (13406561)
1957
44
Abnormal serum protein and bone destruction in transmissible mouse plasma cell neoplasm (multiple myeloma). (13408249)
1957

Variations for Plasma Cell Neoplasm

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Expression for genes affiliated with Plasma Cell Neoplasm

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Search GEO for disease gene expression data for Plasma Cell Neoplasm.

Pathways for genes affiliated with Plasma Cell Neoplasm

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Pathways related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Catalytic cycle of mammalian FMOs38
9.4FMO4, MYC
29.3MYC, CASP14
3
Show member pathways
9.2IL6, AICDA
4
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.0IL6, MYC
5
Show member pathways
Type III interferon signaling38
9.0IL6, MYC
69.0IL6, MYC
7
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.0IL6, MYC
89.0IL6, MYC
99.0MYC, IL6
109.0IL6, MYC
119.0IL6, MYC
129.0MYC, IL6

Compounds for genes affiliated with Plasma Cell Neoplasm

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Compounds related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1cytidine45 26 1311.7MYC, AICDA
2ivig459.5AICDA, IL6
3methylcellulose459.4IL6, PIGA
4vesnarinone459.3IL6, MYC
52,5-oligoadenylate459.3IL6, MYC
6melphalan45 51 1311.3IL6, MYC
715-deoxy-delta-12,14-prostaglandin j2459.3IL6, MYC
8bortezomib45 51 1311.2MYC, IL6
9anisomycin45 1310.2IL6, MYC
10prednisolone45 30 1311.2IL6, MYC
11herbimycin a45 6110.1MYC, IL6
12hyaluronic acid45 2610.1IL6, MYC
13calcitriol45 61 26 1312.0IL6, MYC
14cycloheximide458.8IL6, MYC, AICDA
15curcumin458.7IL6, MYC
16estrogen458.6AICDA, MYC, IL6
17retinoic acid45 269.4CASP14, IL6, MYC

GO Terms for genes affiliated with Plasma Cell Neoplasm

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Biological processes related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of epithelial cell proliferationGO:00506799.0IL6, MYC

Products for genes affiliated with Plasma Cell Neoplasm

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  • Antibodies
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  • Kits and Assays

Sources for Plasma Cell Neoplasm

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet