MCID: PLS009
MIFTS: 37

Plasma Cell Neoplasm malady

Cancer diseases category

Summaries for Plasma Cell Neoplasm

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63Wikipedia, 32MalaCards
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Wikipedia:63 Plasma cell dyscrasias are cancers of the plasma cells. Plasma cell dyscrasias are produced as a result... more...

MalaCards: Plasma Cell Neoplasm, also known as plasma cell dyscrasia, is related to plasmacytoma and leukemia. An important gene associated with Plasma Cell Neoplasm is PIGA (phosphatidylinositol glycan anchor biosynthesis, class A), and among its related pathways are Busulfan Pathway, Pharmacodynamics and IL6-mediated signaling events. The compounds cytidine and methylcellulose have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and bone marrow, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Plasma Cell Neoplasm

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

plasma cell neoplasm 8 60
plasma cell dyscrasia 8 60
plasma cell tumour 8
plasmacytic tumor 8


External Ids:

Disease Ontology8 DOID:6536
NCIt39 C4665
SNOMED-CT56 71390001, 277576009
MeSH34 D010265

Related Diseases for Plasma Cell Neoplasm

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Plasma Cell Neoplasm:



Diseases related to plasma cell neoplasm

Clinical Features for Plasma Cell Neoplasm

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Drugs & Therapeutics for Plasma Cell Neoplasm

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Plasma Cell Neoplasm

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Anatomical Context for Plasma Cell Neoplasm

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32MalaCards
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MalaCards organs/tissues related to Plasma Cell Neoplasm:

32
Bone, B cells, Bone marrow, Thyroid, Nk cells

Animal Models for Plasma Cell Neoplasm or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Plasma Cell Neoplasm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2IL6, MYC, AICDA, PIGA
2MP:00020067.9PIGA, AICDA, MYC, IL6
3MP:00107717.5IL6, MYC, AICDA, PIGA, CASP14

Publications for Plasma Cell Neoplasm

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50PubMed
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Articles related to Plasma Cell Neoplasm:

(show all 42)
idTitleAuthorsYear
1
Epstein-Barr virus-driven bone marrow aplasia and plasmacytosis mimicking a plasma cell neoplasm. (24405048)
2014
2
Practical diagnostic approaches to composite plasma cell neoplasm and low grade B-cell lymphoma/clonal infiltrates in the bone marrow. (24395190)
2014
3
Dysmegakaryocytopoiesis and maintaining platelet count in patients with plasma cell neoplasm. (23814762)
2013
4
Plasma cell neoplasm associated chronic neutrophilic leukemia with membrane proximal and truncating CSF3R mutations. (24033109)
2013
5
Low levels of interleukin-1 receptor antagonist (IL-1RA) predict engraftment syndrome after autologous stem cell transplantation in POEMS syndrome and other plasma cell neoplasms. (23792270)
2013
6
Intracellular and extracellular immunoglobulin crystals assuming a multitude of geometric shapes in an IgG-I> plasma cell neoplasm. (23720061)
2013
7
CD3 expression in plasma cell neoplasm (multiple myeloma): a diagnostic pitfall. (23172088)
2012
8
Risk stratification of plasma cell neoplasm: insights from plasma cell-specific cytoplasmic immunoglobulin fluorescence in situ hybridization (cIg FISH) vs. conventional FISH. (22658896)
2012
9
Scleromyxoedema due to a plasma cell neoplasm: rapid remission with bortezomib, thalidomide and dexamethasone. (22429092)
2012
10
Familial haemophagocytic lymphohistiocytosis-related plasma cell neoplasm: a case report. (22774220)
2012
11
Lower incidence of plasma cell neoplasm is maintained in migrant Chinese to British Columbia: findings from a 30-year survey. (21851219)
2011
12
Plasma cell neoplasm in conjunction with glioblastoma of the conus medullaris. (21325257)
2011
13
Marginal zone B cell lymphomas with extensive plasmacytic differentiation are neoplasms of precursor plasma cells. (21337490)
2011
14
A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene. (20060400)
2010
15
Mandibular radiolucency. Plasma cell neoplasm. (19906620)
2009
16
Ophthalmic presentation of plasma cell neoplasm. (19617795)
2009
17
Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. (17363561)
2007
18
Myc translocations in B cell and plasma cell neoplasms. (16815105)
2006
19
CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms. (16759389)
2006
20
Clinical implication of centrosome amplification in plasma cell neoplasm. (16373658)
2006
21
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. (15735016)
2005
22
Expression of T/NK-cell and plasma cell antigens in nonhematopoietic epithelioid neoplasms. An immunohistochemical study of 447 cases. (12866374)
2003
23
Multiple Endocrine Neoplasms in a Patient with AL Amyloidosis-Associated Plasma Cell Dyscrasia. (12114636)
1997
24
Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse. (3029337)
1987
25
Treatment of plasma cell neoplasm with recombinant leukocyte A interferon and human lymphoblastoid interferon. (3917376)
1985
26
Thyroid-gland plasma cell neoplasm (plasmacytoma). (7027992)
1981
27
An unusual case of a plasma cell neoplasm with an IgG3lambda myeloma and a gamma3 heavy chain disease protein. (412532)
1978
28
Plasma cell neoplasm involving the thyroid. (638958)
1978
29
Tumor cell invasion of hepatocytes in transplantable plasma cell neoplasm of mice. (4344454)
1972
30
Ploidy fluctuations of mouse plasma-cell neoplasm MSPC-1 during serial transplantation. (5157581)
1971
31
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine. (4254308)
1970
32
Studies on the murine plasma-cell neoplasm, X5563. II. Accelerated immunologic reactivity to transplanted tumor induced in C3H mice by transferred immune rabbit cells. (6053557)
1967
33
PLASMA CELL NEOPLASM ARISING IN A CAF MOUSE. CHARACTERISTICS AND RESPONSE TO CERTAIN CHEMOTHERAPEUTIC AGENTS. (14207853)
1964
34
BIOCHEMICAL EFFECTS OF DUAZOMYCIN A IN THE MOUSE PLASMA CELL NEOPLASM 70429. (14096421)
1963
35
Azaserine resistance in a plasma-cell neoplasm without change in active transport of the inhibitor. (13861221)
1962
36
A study on globulin formation by plasma-cell neoplasm (5563) transplantable in mice. (13684805)
1961
37
Distinctive myeloma globulins associated with a new plasma cell neoplasm of strain C3H mice. (13821296)
1960
38
Alterations of gamma globulin with plasma cell neoplasm in mice. (13675239)
1959
39
Bence Jones proteinuria associated with a transplantable mouse plasma-cell neoplasm. (13821298)
1959
40
Growth inhibition of homografts of a plasma-cell neoplasm in cell-impenetrable diffusion chambers placed in hyperimmunized mice. (13792639)
1959
41
Studies of a plasma-cell neoplasm of the mouse. I. Characterization of neoplasm 70429, including its sensitivity to various antimetabolites with the rapid development of resistance to azaserine, DON, and N-methylformamide. (13406561)
1957
42
Abnormal serum protein and bone destruction in transmissible mouse plasma cell neoplasm (multiple myeloma). (13408249)
1957

Genetic Variations for Plasma Cell Neoplasm

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Expression for genes affiliated with Plasma Cell Neoplasm

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plasma Cell Neoplasm

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Pathways for genes affiliated with Plasma Cell Neoplasm

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49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MYC, FMO4
29.0IL6, MYC
39.0IL6, MYC
49.0IL6, MYC

Compounds for genes affiliated with Plasma Cell Neoplasm

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cytidine44 11 2411.5MYC, AICDA
2methylcellulose449.4IL6, PIGA
3ivig449.3AICDA, IL6
4vesnarinone449.2IL6, MYC
52,5-oligoadenylate449.2IL6, MYC
6melphalan44 1110.0IL6, MYC
7anisomycin44 1110.0IL6, MYC
815-deoxy-delta-12,14-prostaglandin j2448.9IL6, MYC
9bortezomib44 119.7IL6, MYC

GO Terms for genes affiliated with Plasma Cell Neoplasm

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16Gene Ontology
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Biological processes related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of epithelial cell proliferationGO:0506799.0IL6, MYC

Products for genes affiliated with Plasma Cell Neoplasm

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Sources for Plasma Cell Neoplasm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet