Plasma Cell Neoplasm disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Plasma Cell Neoplasm

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⁶⁴Wikipedia, ³²MalaCards
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IL6 antibody
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Wikipedia:⁶⁴ Plasma cell dyscrasias are disorders of the plasma cells. Plasma cell dyscrasias are produced as a... more...

MalaCards based summary: Plasma Cell Neoplasm, also known as plasma cell dyscrasia, is related to plasmacytoma and b-cell lymphomas. An important gene associated with Plasma Cell Neoplasm is FMO4 (flavin containing monooxygenase 4), and among its related pathways are Busulfan Pathway, Pharmacodynamics and Apoptosis and Autophagy. The drugs carmustine and cisplatin and the compounds cytidine and ivig have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and bone marrow, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Plasma Cell Neoplasm

Sources:
⁹Disease Ontology, ⁶¹UMLS, ⁵⁶SNOMED-CT, ³⁴MeSH, ³⁹NCIt
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Plasma Cell Neoplasm, Aliases & Descriptions:

Name: Plasma Cell Neoplasm ⁹ ⁶¹

Plasma Cell Dyscrasia ⁹ ⁶¹

Plasma Cell Tumour ⁹

Plasmacytic Tumor ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases

External Ids:

Disease Ontology⁹ DOID:6536

MeSH³⁴ D010265

SNOMED-CT⁵⁶ 71390001, 277576009

NCIt³⁹ C4665

UMLS⁶¹ C1136084

Related Diseases for Plasma Cell Neoplasm

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
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Diseases related to Plasma Cell Neoplasm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 70)

id	Related Disease	Score	Top Affiliating Genes
1	plasmacytoma	30.2	AICDA, MYC, IL6
2	b-cell lymphomas	29.9	AICDA, MYC
3	leukemia	29.3	AICDA, MYC, IL6, PIGA
4	polyneuropathy	10.6
5	amyloidosis	10.5
6	systemic mastocytosis	10.4
7	mastocytosis	10.4
8	multiple myeloma	10.4
9	myeloma	10.4
10	angiodysplasia	10.3
11	pure red-cell aplasia	10.3
12	fanconi syndrome	10.3
13	von willebrand's disease	10.3
14	vitamin b12 deficiency	10.3
15	refractory plasma cell neoplasm	10.3
16	thyroiditis	10.2
17	arthritis	10.2
18	diabetes mellitus	10.2
19	myelofibrosis	10.2
20	osteoporosis	10.2
21	rheumatoid arthritis	10.2
22	factor x deficiency	10.2
23	tuberculoid leprosy	10.2
24	smoldering myeloma	10.2
25	macroglobulinemia	10.2
26	polycythemia vera	10.2
27	cutis laxa	10.2
28	agammaglobulinemia	10.2
29	demyelinating polyneuropathy	10.2
30	hypertrichosis	10.2
31	interstitial nephritis	10.2
32	leprosy	10.2
33	mediastinitis	10.2
34	nephrotic syndrome	10.2
35	polycythemia	10.2
36	scleroderma	10.2
37	stomatitis	10.2
38	ulcerative stomatitis	10.2
39	al amyloidosis	10.2
40	amyloid neuropathy	10.2
41	chromosome 12p deletion	10.2
42	erythema elevatum diutinum	10.2
43	immunotactoid glomerulopathy	10.2
44	necrobiotic xanthogranuloma	10.2
45	tempi syndrome	10.2
46	amyloidosis, secondary	10.2
47	erythrocytosis	10.2
48	nephritis	10.2
49	xanthoma disseminatum	10.2
50	acquired cutis laxa	10.2

Graphical network of the top 20 diseases related to Plasma Cell Neoplasm:

Symptoms for Plasma Cell Neoplasm

Drugs & Therapeutics for Plasma Cell Neoplasm

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Plasma Cell Neoplasm

Search NIH Clinical Center for Plasma Cell Neoplasm

Inferred drug relations via UMLS⁶¹/NDF-RT⁴⁰:

Genetic Tests for Plasma Cell Neoplasm

Anatomical Context for Plasma Cell Neoplasm

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³²MalaCards
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MalaCards organs/tissues related to Plasma Cell Neoplasm:

³²

Bone, B cells, Bone marrow, Thyroid, Neutrophil

Animal Models for Plasma Cell Neoplasm or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Plasma Cell Neoplasm:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	tumorigenesis	MP:0002006	8.1	PIGA, MYC, IL6, AICDA
2	cellular phenotype	MP:0005384	8.1	AICDA, PIGA, MYC, IL6
3	digestive/alimentary phenotype	MP:0005381	8.0	AICDA, PIGA, MYC, IL6
4	hematopoietic system phenotype	MP:0005397	7.8	AICDA, PIGA, MYC, IL6
5	integument phenotype	MP:0010771	7.6	MYC, AICDA, PIGA, IL6, CASP14

Publications for Plasma Cell Neoplasm

Sources:
⁵¹PubMed
See all sources

Articles related to Plasma Cell Neoplasm:

(show all 41)

id	Title	Authors	Year
1	Crystal-storing histiocytosis with IgD I_-associated plasma cell neoplasm. (25028748)	Thakral B.... Courville E.	2014
2	Classical Hodgkin lymphoma with coexistant plasma cell neoplasm: A case report. (25308039)	Arora N.... Nair R.	2014
3	Epstein-Barr virus-driven bone marrow aplasia and plasmacytosis mimicking a plasma cell neoplasm. (24405048)	Desborough M.J.... Grech H.	2014
4	Image of the month : a rare presentation of a plasma cell neoplasm. (25333092)		2014
5	Practical diagnostic approaches to composite plasma cell neoplasm and low grade B-cell lymphoma/clonal infiltrates in the bone marrow. (24395190)	Hussein S.... Alobeid B.	2014
6	Dysmegakaryocytopoiesis and maintaining platelet count in patients with plasma cell neoplasm. (23814762)	Mair Y.... Cai D.	2013
7	Plasma cell neoplasm associated chronic neutrophilic leukemia with membrane proximal and truncating CSF3R mutations. (24033109)	Blombery P.... Khwaja A.	2013
8	Low levels of interleukin-1 receptor antagonist (IL-1RA) predict engraftment syndrome after autologous stem cell transplantation in POEMS syndrome and other plasma cell neoplasms. (23792270)	Keyzner A.... Dispenzieri A.	2013
9	Intracellular and extracellular immunoglobulin crystals assuming a multitude of geometric shapes in an IgG-I> plasma cell neoplasm. (23720061)	Srivastava S.... Ornstein D.L.	2013
10	CD3 expression in plasma cell neoplasm (multiple myeloma): a diagnostic pitfall. (23172088)	Tang Y.L.... Chuah K.L.	2012
11	Risk stratification of plasma cell neoplasm: insights from plasma cell-specific cytoplasmic immunoglobulin fluorescence in situ hybridization (cIg FISH) vs. conventional FISH. (22658896)	Dong H.... Chari A.	2012
12	Scleromyxoedema due to a plasma cell neoplasm: rapid remission with bortezomib, thalidomide and dexamethasone. (22429092)	Yeung C.K.... Kwong Y.L.	2012
13	Familial haemophagocytic lymphohistiocytosis-related plasma cell neoplasm: a case report. (22774220)	Pizzi M.... Pileri S.A.	2012
14	Lower incidence of plasma cell neoplasm is maintained in migrant Chinese to British Columbia: findings from a 30-year survey. (21851219)	Chan V.... Au W.Y.	2011
15	Plasma cell neoplasm in conjunction with glioblastoma of the conus medullaris. (21325257)	Williams S.R.... Parker J.C.	2011
16	A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene. (20060400)	Araten D.J.... Sanders K.J.	2010
17	Mandibular radiolucency. Plasma cell neoplasm. (19906620)	Damm D.D.	2009
18	Ophthalmic presentation of plasma cell neoplasm. (19617795)	Person E.A.... Rupani M.K.	2009
19	Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. (17363561)	Qi C.F.... Morse H.C.	2007
20	Myc translocations in B cell and plasma cell neoplasms. (16815105)	Janz S.	2006
21	CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms. (16759389)	Han S.S.... Janz S.	2006
22	Clinical implication of centrosome amplification in plasma cell neoplasm. (16373658)	Chng W.J.... Fonseca R.	2006
23	Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. (15735016)	Park S.S.... Janz S.	2005
24	Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse. (3029337)	Nemni R.... Canal N.	1987
25	Treatment of plasma cell neoplasm with recombinant leukocyte A interferon and human lymphoblastoid interferon. (3917376)	Ohno R.... Morishima Y.	1985
26	Thyroid-gland plasma cell neoplasm (plasmacytoma). (7027992)	Macpherson T.A.... Kapadia S.B.	1981
27	An unusual case of a plasma cell neoplasm with an IgG3lambda myeloma and a gamma3 heavy chain disease protein. (412532)	Adlersberg J.B.... Franklin E.C.	1978
28	Plasma cell neoplasm involving the thyroid. (638958)	Shimaoka K.... Barcos M.	1978
29	Tumor cell invasion of hepatocytes in transplantable plasma cell neoplasm of mice. (4344454)	Sarkar K.	1972
30	Ploidy fluctuations of mouse plasma-cell neoplasm MSPC-1 during serial transplantation. (5157581)	Moriwaki K.... Yosida T.H.	1971
31	Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine. (4254308)	Everson R.... Hall T.C.	1970
32	Studies on the murine plasma-cell neoplasm, X5563. II. Accelerated immunologic reactivity to transplanted tumor induced in C3H mice by transferred immune rabbit cells. (6053557)	Gordon BL I.I.... Fong J.	1967
33	PLASMA CELL NEOPLASM ARISING IN A CAF MOUSE. CHARACTERISTICS AND RESPONSE TO CERTAIN CHEMOTHERAPEUTIC AGENTS. (14207853)	YANCEY S.T.	1964
34	Azaserine resistance in a plasma-cell neoplasm without change in active transport of the inhibitor. (13861221)	ANDERSON E.P.... JACQUEZ J.A.	1962
35	A study on globulin formation by plasma-cell neoplasm (5563) transplantable in mice. (13684805)	ASKONAS B.A.	1961
36	Distinctive myeloma globulins associated with a new plasma cell neoplasm of strain C3H mice. (13821296)	Fahey J.L.... Dunn T.B.	1960
37	Alterations of gamma globulin with plasma cell neoplasm in mice. (13675239)	COBAU C.D.... KORST D.R.	1959
38	Bence Jones proteinuria associated with a transplantable mouse plasma-cell neoplasm. (13821298)	Fahey J.L.... Potter M.	1959
39	Growth inhibition of homografts of a plasma-cell neoplasm in cell-impenetrable diffusion chambers placed in hyperimmunized mice. (13792639)	ALGIRE G.H.	1959
40	Studies of a plasma-cell neoplasm of the mouse. I. Characterization of neoplasm 70429, including its sensitivity to various antimetabolites with the rapid development of resistance to azaserine, DON, and N-methylformamide. (13406561)	Potter M.... Law L.W.	1957
41	Abnormal serum protein and bone destruction in transmissible mouse plasma cell neoplasm (multiple myeloma). (13408249)	Potter M.... PILGRIM H.I.	1957

Genes related to Plasma Cell Neoplasm

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
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Genes related to Plasma Cell Neoplasm:

- Elite gene

id	Symbol	Description	Score	Implication
1	FMO4	flavin containing monooxygenase 4	21.71	GeneCards inferred via : Publications (show sections)
2	AICDA	activation-induced cytidine deaminase	18.38	GeneCards inferred via : Publications (show sections)
3	PIGA	phosphatidylinositol glycan anchor biosynthesis, class A	15.04	GeneCards inferred via : Publications (show sections)
4	MYC	v-myc avian myelocytomatosis viral oncogene homolog	11.71	GeneCards inferred via : Publications (show sections)
5	IL6	interleukin 6 (interferon, beta 2)	8.38	GeneCards inferred via : Publications (show sections)
6	CASP14	caspase 14, apoptosis-related cysteine peptidase	5.04	GeneCards inferred via : Publications (show sections)

Products for genes related to Plasma Cell Neoplasm disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	6	-	6	6
2	Novus Biologicals	6	4	6	-

Variations for Plasma Cell Neoplasm

Expression for genes affiliated with Plasma Cell Neoplasm

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plasma Cell Neoplasm

Search GEO for disease gene expression data for Plasma Cell Neoplasm.

Pathways for genes affiliated with Plasma Cell Neoplasm

Sources:
⁴⁹PathCards, ⁵⁰PharmGKB, ³⁷NCBI BioSystems Database, ⁵⁴Reactome, ⁵Cell Signaling Technology, ³⁰KEGG, ⁵²QIAGEN, ⁵³R&D Systems, ⁵⁹Thomson Reuters
See all sources

Pathways related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

(show all 12)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Busulfan Pathway, Pharmacodynamics⁵⁰ Show member pathways Catalytic cycle of mammalian FMOs³⁷ FMO oxidizes nucleophiles⁵⁴	9.4	FMO4, MYC
2	Apoptosis and Autophagy⁵	9.3	MYC, CASP14
3	Allograft rejection³⁰ Show member pathways Autoimmune thyroid disease³⁰ Viral myocarditis³⁰ Intestinal immune network for IgA production³⁰ Allograft Rejection³⁷ Asthma³⁰ Type I diabetes mellitus³⁰ Graft-versus-host disease³⁰ CTL Mediated Apoptosis⁵² Antigen processing and presentation³⁰ THC Differentiation Pathway⁵²	9.2	IL6, AICDA
4	IL-9 Signaling Pathways⁵³ Show member pathways IL-21 Signaling Pathways⁵³ IL-9 Signaling Pathway³⁷ Common Cytokine Receptor Gamma-Chain Family Signaling Pathways⁵³ Development Thrombopoietin regulated cell processes⁵⁹ IL-15 Signaling Pathways⁵³ IL-7 Signaling Pathways⁵³ Adipocytokines and Insulin Signaling⁵³ IL-7 Signaling Pathway³⁷ IL-2 Signaling Pathways⁵³ Immune response IL 9 signaling pathway⁵⁹ IL-4 Signaling Pathways⁵³ IL-9 Pathway⁵²	9.0	IL6, MYC
5	Jak-STAT signaling pathway³⁰ Show member pathways Type III interferon signaling³⁷	9.0	IL6, MYC
6	Transcriptional misregulation in cancer³⁰	9.0	IL6, MYC
7	Immune response IL 23 signaling pathway⁵⁹ Show member pathways IL23-mediated signaling events³⁷ Angiopoietin-TIE2 Signaling⁵² Immune response IL 10 signaling pathway⁵⁹ Angiopoietin receptor Tie2-mediated signaling³⁷ Development PDGF signaling via STATs and NF kB⁵⁹ Development Angiopoietin Tie2 signaling⁵⁹	9.0	IL6, MYC
8	TSLP Signaling Pathway³⁷	9.0	IL6, MYC
9	IL6-mediated signaling events³⁷	9.0	MYC, IL6
10	Spinal Cord Injury³⁷	9.0	IL6, MYC
11	IL-10 Pathway⁵²	9.0	IL6, MYC
12	Colorectal Cancer Metastasis⁵²	9.0	MYC, IL6

Compounds for genes affiliated with Plasma Cell Neoplasm

Sources:
⁴⁴Novoseek, ²⁵HMDB, ¹²DrugBank, ⁵⁰PharmGKB, ²⁹IUPHAR, ⁶⁰Tocris Bioscience
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Compounds related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

(show all 17)

id	Compound	Score	Top Affiliating Genes
1	cytidine⁴⁴ ²⁵ ¹²	11.7	MYC, AICDA
2	ivig⁴⁴	9.5	AICDA, IL6
3	methylcellulose⁴⁴	9.4	IL6, PIGA
4	vesnarinone⁴⁴	9.3	IL6, MYC
5	2,5-oligoadenylate⁴⁴	9.3	IL6, MYC
6	melphalan⁴⁴ ⁵⁰ ¹²	11.3	IL6, MYC
7	15-deoxy-delta-12,14-prostaglandin j2⁴⁴	9.3	IL6, MYC
8	bortezomib⁴⁴ ⁵⁰ ¹²	11.2	MYC, IL6
9	anisomycin⁴⁴ ¹²	10.2	IL6, MYC
10	prednisolone⁴⁴ ²⁹ ¹²	11.2	IL6, MYC
11	herbimycin a⁴⁴ ⁶⁰	10.1	MYC, IL6
12	hyaluronic acid⁴⁴ ²⁵	10.1	IL6, MYC
13	calcitriol⁴⁴ ⁶⁰ ²⁵ ¹²	12.0	IL6, MYC
14	cycloheximide⁴⁴	8.8	IL6, MYC, AICDA
15	curcumin⁴⁴	8.7	IL6, MYC
16	estrogen⁴⁴	8.6	AICDA, MYC, IL6
17	retinoic acid⁴⁴ ²⁵	9.4	CASP14, IL6, MYC

GO Terms for genes affiliated with Plasma Cell Neoplasm

Sources:
¹⁷Gene Ontology
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Biological processes related to Plasma Cell Neoplasm according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of epithelial cell proliferation	GO:050679	9.0	IL6, MYC

Products for genes affiliated with Plasma Cell Neoplasm

Antibodies
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Sources for Plasma Cell Neoplasm

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: PLS009 MIFTS: 46	Plasma Cell Neoplasm malady Cancer diseases category
23 drugs, 6 genes, 5 tissues, 70 related diseases, clinical trials Download this MalaCard Expand all tables

Plasma Cell Neoplasm malady