MCID: PLS025
MIFTS: 46

Plasmablastic Lymphoma malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Plasmablastic Lymphoma

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MalaCards based summary: Plasmablastic Lymphoma, also known as pbl, is related to hiv-1 and primary effusion lymphoma. An important gene associated with Plasmablastic Lymphoma is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Interferon type I and Pre-NOTCH Expression and Processing. The compounds temsirolimus and tachyplesin i have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and spinal cord, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Plasmablastic Lymphoma

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Sources:
41NIH Rare Diseases, 47Orphanet, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Plasmablastic Lymphoma, Aliases & Descriptions:

Name: Plasmablastic Lymphoma 41 47 60
Pbl 41 47
 
Immunoblastic Large-Cell Lymphoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


External Ids:

Orphanet47 289666
ICD10 via Orphanet26 C83.3
UMLS via Orphanet61 C3472614

Related Diseases for Plasmablastic Lymphoma

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Diseases related to Plasmablastic Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1hiv-130.6CD38, BCL6, PTPRC
2primary effusion lymphoma30.6MYC, BCL6
3mantle cell lymphoma30.4BCL6, CCND1
4burkitt lymphoma30.3BCL6, CCND1
5plasmacytoma30.2IGH, PTPRC, MYC, IRF4, BCL6
6hodgkin lymphoma30.2IGH, PTPRC, IRF4, MS4A1, BCL6
7sarcoma30.0MTOR, PTPRC, ABCB1
8chronic lymphocytic leukemia29.8ABCB1, IGH, MS4A1, CCND1, BCL6, CD38
9myeloid leukemia29.8CD38, MYC, PTPRC, ABCB1
10t-cell leukemia29.7IGH, PTPRC, MYC, IRF4, NOTCH1
11b-cell lymphomas29.4IGH, PTPRC, MYC, IRF4, MS4A1, CCND1
12follicular lymphoma29.3IGH, PTPRC, MYC, IRF4, MS4A1, CCND1
13glioblastoma29.3ABCB1, MYC, CCND1, MTOR, CDKN2A
14lung cancer29.1ABCB1, MYC, CCND1, MTOR, CDKN2A
15myeloma28.7ABCB1, IGH, PTPRC, MYC, IRF4, CCND1
16leukemia28.3NOTCH1, CDKN2A, CD38, BCL6, MTOR, CCND1
17testicular lymphoma10.5BCL6
18crohn's disease10.4
19diffuse large b-cell lymphoma10.4
20gingivitis10.4
21gastric lymphoma10.4IGH, BCL6
22lymphosarcoma10.3IGH, BCL6
23angiomyolipoma10.3MTOR, PTPRC
24reticulosarcoma10.2IGH, PTPRC, BCL6
25peripheral t-cell lymphoma10.2BCL6, MS4A1, PTPRC
26anaplastic large cell lymphoma10.1BCL6, PTPRC
27hepatitis c virus10.1
28hematopoietic stem cell transplantation10.1
29hepatitis10.1
30hepatitis c10.1
31richter's syndrome10.1
32acquired immunodeficiency syndrome10.1
33duodenitis10.1
34orbital cellulitis10.1
35cellulitis10.1
36cervicitis10.1
37esophagitis10.1
38peritonitis10.1
39rectal disease10.1
40castleman's disease10.1
41essential thrombocythemia10.1
42tonsil squamous cell carcinoma10.1CCND1, CDKN2A
43malignant peripheral nerve sheath tumor10.1CDKN2A, ABCB1
44polycystic kidney disease, autosomal dominant10.1MYC, MTOR
45lymphoblastic lymphoma10.0PTPRC, MS4A1, BCL6, NOTCH1
46chromosomal triplication10.0IGH, MYC, BCL6, CD38
47ipex syndrome10.0PTPRC, MS4A1, BCL6, CD38
48rheumatoid arthritis10.0
49esophageal cancer10.0
50renal cell carcinoma10.0

Graphical network of the top 20 diseases related to Plasmablastic Lymphoma:



Diseases related to plasmablastic lymphoma

Symptoms for Plasmablastic Lymphoma

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Drugs & Therapeutics for Plasmablastic Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Plasmablastic Lymphoma

Search NIH Clinical Center for Plasmablastic Lymphoma

Genetic Tests for Plasmablastic Lymphoma

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Anatomical Context for Plasmablastic Lymphoma

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MalaCards organs/tissues related to Plasmablastic Lymphoma:

31
B cells, Bone, Spinal cord, Liver, Lymph node, Small intestine, Lung, Breast, Skin, Testes, Bone marrow, Colon, Uterus, Testis, Cervix

Animal Models for Plasmablastic Lymphoma or affiliated genes

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Publications for Plasmablastic Lymphoma

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Articles related to Plasmablastic Lymphoma:

(show top 50)    (show all 210)
idTitleAuthorsYear
1
A unique presentation of unilateral pleural effusion in a patient with plasmablastic lymphoma. (25686646)
2015
2
Plasmablastic lymphoma of the stomach with C-MYC rearrangement in an immunocompetent young adult: a case report. (25634193)
2015
3
Autologous Hematopoietic Stem Cell Transplantation for Plasmablastic Lymphoma: The European Society for Blood and Marrow Transplantation Experience. (25783635)
2015
4
Manifestations of gastrointestinal plasmablastic lymphoma: a case series with literature review. (25206297)
2014
5
Human immunodeficiency virus-negative plasmablastic lymphoma in the neck: a rare case report and literature review. (25416032)
2014
6
Extensive maxillofacial plasmablastic lymphoma in an immunocompetent patient. (25103486)
2014
7
Extraoral plasmablastic lymphoma detected using ascitic fluid cytology and flow cytometry: a case report with a review of the literature. (24685599)
2014
8
CD20-positive plasmablastic lymphoma with excellent response to bortezomib combined with rituximab. (24528507)
2014
9
Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation. (24349055)
2013
10
Brentuximab vedotin demonstrates activity in a patient with plasmablastic lymphoma arising from a background of chronic lymphocytic leukemia. (23509308)
2013
11
An uncommon case of epidural plasmablastic lymphoma presents as spinal cord compression. (23993656)
2013
12
Primary cutaneous plasmablastic lymphoma in an immunocompetent patient. (24124865)
2013
13
Bortezomib in plasmablastic lymphoma: a case report and review of the literature. (23689224)
2013
14
Multifocal cranial plasmablastic lymphoma as a rare manifestation of posttransplant lymphoproliferative disorder. (22976265)
2012
15
Quantification of plasma Epstein-Barr virus DNA for assessing treatment response in a patient with plasmablastic lymphoma. (21881823)
2012
16
Lack and/or aberrant localization of major histocompatibility class II (MHCII) protein in plasmablastic lymphoma. (22689685)
2012
17
Plasmablastic Lymphoma presenting as small intestinal polyposis: A case-report. (23285420)
2012
18
Unusual presentation of gastric plasmablastic lymphoma in HIV-negative patient. (21476144)
2012
19
Oral and extraoral plasmablastic lymphoma: similarities and differences in clinicopathologic characteristics. (21571968)
2011
20
Oral plasmablastic lymphoma: a case report. (21884151)
2011
21
Uniform expression of Notch1, suppressor of B-cell-specific gene expression, in plasmablastic lymphoma. (21631271)
2011
22
Interesting image. Assessment of plasmablastic lymphoma by F-18 FDG PET/CT: case report. (20940549)
2010
23
Rare AIDS-associated plasmablastic lymphoma as the initial presentation of AIDS. (20351683)
2010
24
Plasmablastic lymphoma with MYC translocation: evidence for a common pathway in the generation of plasmablastic features. (20348882)
2010
25
Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement. (21088162)
2010
26
Diagnosis and treatment of myelo-osteolytic plasmablastic lymphoma of the femur in a domestic ferret. (20707751)
2010
27
Plasmablastic lymphoma in the anal canal. (19809569)
2009
28
Plasmablastic lymphoma in an immunocompetent patient. (19581534)
2009
29
Cutaneous nodules as diagnostic key of an extraoral plasmablastic lymphoma in an human immunodeficiency virus-infected patient. (18028356)
2008
30
Plasmablastic lymphoma involving breast: a case diagnosed by fine-needle aspiration and core needle biopsy. (18335555)
2008
31
Sonographic appearance of plasmablastic lymphoma of the testes. (18499857)
2008
32
Plasmablastic lymphoma mimicking orbital cellulitis. (18597126)
2008
33
EBV detection in HIV-related oral plasmablastic lymphoma. (17944673)
2007
34
Images in HIV/AIDS. Oral plasmablastic lymphoma. (17902226)
2007
35
Extranodal plasmablastic lymphoma arising in mantle cell lymphoma. (17903200)
2007
36
Plasmablastic lymphoma of head and neck: report of two new cases and correlation with c-myc and IgVH gene mutation status. (20614267)
2007
37
Editorial comment: plasmablastic lymphoma--a diagnostic and therapeutic puzzle. (17902227)
2007
38
Extra-oral plasmablastic lymphoma: report of a case and review of literature. (16938530)
2006
39
Incidental oral plasmablastic lymphoma with aberrant expression of CD4 in an elderly HIV-negative patient: how a gingival polyp can cause confusion. (15720425)
2005
40
Cytologic features of plasmablastic lymphoma. (15803491)
2005
41
Improved outcome of human immunodeficiency virus-associated plasmablastic lymphoma of the oral cavity in the era of highly active antiretroviral therapy: a report of two cases. (15223650)
2004
42
Cutaneous plasmablastic lymphoma in an HIV-positive male: an unrecognized cutaneous manifestation. (15118393)
2004
43
Plasmablastic lymphoma of the cervical lymph nodes in a human immunodeficiency virus-negative patient: a case report and review of the literature. (15086296)
2004
44
Plasmablastic lymphoma presenting in a human immunodeficiency virus-negative patient: a case report. (12783213)
2003
45
Plasmablastic lymphoma of the oral cavity and jaws. (12351965)
2002
46
Molecular histogenesis of plasmablastic lymphoma of the oral cavity. (12437635)
2002
47
Plasmablastic lymphoma of the lung: report of a unique case and review of the literature. (11175653)
2001
48
HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. (10666218)
2000
49
Plasmablastic lymphoma of the stomach. A case report. (9542326)
1998
50
Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. (9028965)
1997

Variations for Plasmablastic Lymphoma

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Expression for genes affiliated with Plasmablastic Lymphoma

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Search GEO for disease gene expression data for Plasmablastic Lymphoma.

Pathways for genes affiliated with Plasmablastic Lymphoma

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Pathways related to Plasmablastic Lymphoma according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MTOR, PTPRC
2
Show member pathways
9.6NOTCH1, CCND1
39.5MTOR, MYC
49.5MYC, MTOR
59.4MYC, CDKN2A
6
Show member pathways
9.4MYC, CDKN2A
79.3MYC, CCND1
89.3CCND1, MYC
99.3CCND1, MYC
109.3CCND1, MYC
119.3BCL6, MTOR, IRF4
12
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.2CDKN2A, IRF4, MYC
13
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.0MTOR, CCND1, MYC
14
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.0MTOR, CCND1, MYC
15
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.0MTOR, CCND1, MYC
16
Show member pathways
Signal transduction PTEN pathway58
9.0MTOR, CCND1, MYC
179.0MTOR, CCND1, MYC
189.0MYC, CCND1, MTOR
19
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.0MYC, CCND1, MTOR
209.0MYC, CCND1, MTOR
21
Show member pathways
Notch signaling pathway36
9.0NOTCH1, CCND1, MYC
229.0MYC, CCND1, NOTCH1
23
Show member pathways
9.0MYC, CCND1, NOTCH1
248.9CDKN2A, CCND1, MYC
25
Show member pathways
8.9CDKN2A, CCND1, MYC
268.9MYC, CCND1, CDKN2A
27
Show member pathways
Cell cycle36
8.9MYC, CCND1, CDKN2A
28
Show member pathways
8.9MYC, CCND1, CDKN2A
29
Show member pathways
DNA damage response36
8.9MYC, CCND1, CDKN2A
308.9CCND1, MYC, ABCB1
31
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
8.8IGH, PTPRC, BCL6
328.6NOTCH1, MTOR, CCND1, MYC
33
Show member pathways
Signaling Pathways in Glioblastoma36
8.6CDKN2A, MTOR, CCND1, MYC
348.6CDKN2A, MTOR, CCND1, MYC
35
Show member pathways
8.5CDKN2A, NOTCH1, CCND1, MYC
36
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
8.4MYC, CCND1, BCL6, CDKN2A
37
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
8.2IGH, MYC, CCND1, MTOR
388.1NOTCH1, BCL6, MTOR, CCND1, MYC
397.7ABCB1, MYC, CCND1, MTOR, NOTCH1, CDKN2A

Compounds for genes affiliated with Plasmablastic Lymphoma

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Compounds related to Plasmablastic Lymphoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1temsirolimus43 1210.9ABCB1, MTOR
2tachyplesin i439.8CDKN2A, MYC
3hematoxylin439.8CDKN2A, MS4A1, PTPRC
4trimetrexate43 1210.8ABCB1, CDKN2A
5acnu439.7ABCB1, CDKN2A
6erlotinib43 49 1211.5MTOR, CCND1, ABCB1
7farnesylthiosalicylic acid28 4310.5CCND1, MTOR
8sorafenib43 49 1211.5ABCB1, CCND1, MTOR
9rituximab43 49 1211.5MS4A1, MTOR, BCL6, CD38
10everolimus43 49 1211.4MYC, CCND1, MTOR
11gefitinib43 49 1211.4ABCB1, CCND1, MTOR
12pga2439.3MYC, CCND1
13roscovitine439.3MYC, CCND1, CDKN2A
14cyclophosphamide43 49 1211.3BCL6, MTOR, MS4A1, ABCB1
15daunorubicin43 49 1211.3CDKN2A, MYC, ABCB1
16melphalan43 49 1211.2ABCB1, MYC, CCND1
17docetaxel43 49 59 1212.0CDKN2A, MTOR, MYC, ABCB1
1812-o-tetradecanoylphorbol 13-acetate439.0PTPRC, MYC, MTOR, BCL6
19gemcitabine43 49 1211.0CCND1, MYC, ABCB1
20n acetylcysteine438.9PTPRC, MYC, CCND1, CDKN2A
21tacrolimus43 49 1210.9MTOR, CCND1, MYC, ABCB1
22depsipeptide438.9CDKN2A, CCND1, MYC, ABCB1
23actinomycin d438.9CD38, CDKN2A, MYC, ABCB1
24adriamycin438.9ABCB1, MYC, CCND1, CDKN2A
25rapamycin438.9MYC, CCND1, MTOR, NOTCH1
26ly294002438.9NOTCH1, MTOR, CCND1, MYC
27tamoxifen43 49 28 1211.9MTOR, CCND1, MYC, ABCB1
28lipid438.8CD38, CDKN2A, NOTCH1, MTOR, MS4A1, PTPRC
29testosterone43 59 24 1211.8ABCB1, PTPRC, CCND1, MTOR, CDKN2A
30lovastatin43 49 59 28 1212.8ABCB1, CCND1, CDKN2A
31paclitaxel43 49 1210.8ABCB1, MYC, CCND1, CDKN2A
32cyclosporin a43 28 5910.7MTOR, MYC, PTPRC, ABCB1
33glycogen43 249.7NOTCH1, MTOR, CCND1, MYC, PTPRC
34agarose438.7IGH, PTPRC, MYC, CDKN2A
35arsenite43 249.6ABCB1, MYC, CCND1, MTOR, CDKN2A
36cisplatin43 49 59 1211.5ABCB1, MYC, CCND1, MTOR, CDKN2A
37vegf438.5MYC, CCND1, MTOR, NOTCH1, CDKN2A
38cycloheximide438.5PTPRC, MYC, CCND1, BCL6, CDKN2A
39imatinib43 49 1210.4ABCB1, MYC, CCND1, MTOR, BCL6
40phosphatidylinositol438.4PTPRC, MYC, CCND1, MTOR, NOTCH1, CD38
41vincristine43 49 1210.4ABCB1, MYC, CCND1, BCL6, CDKN2A
42threonine438.3PTPRC, MYC, CCND1, MTOR, NOTCH1, CDKN2A
43paraffin438.3PTPRC, MYC, MS4A1, CCND1, BCL6, CDKN2A
44dexamethasone43 49 28 1211.1ABCB1, PTPRC, MYC, MTOR, NOTCH1, CDKN2A
45genistein43 28 59 2 24 1212.9ABCB1, PTPRC, MYC, CCND1, MTOR, NOTCH1
46tyrosine437.9PTPRC, MYC, CCND1, MTOR, BCL6, NOTCH1
47retinoic acid43 248.8MYC, CCND1, MTOR, BCL6, NOTCH1, CDKN2A
48estrogen437.8PTPRC, MYC, CCND1, MTOR, BCL6, NOTCH1
49serine437.8PTPRC, MYC, CCND1, MTOR, BCL6, NOTCH1
50doxorubicin43 49 129.7CDKN2A, ABCB1, MYC, CCND1, MTOR, BCL6

GO Terms for genes affiliated with Plasmablastic Lymphoma

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Cellular components related to Plasmablastic Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:00160208.9CD38, MTOR, CCND1, ABCB1

Biological processes related to Plasmablastic Lymphoma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1somatic stem cell divisionGO:00481039.9CDKN2A, NOTCH1
2B cell receptor signaling pathwayGO:00508539.9PTPRC, CD38
3B cell proliferationGO:00421009.8PTPRC, MS4A1
4negative regulation of cell-matrix adhesionGO:00019539.7BCL6, CDKN2A
5positive regulation of B cell proliferationGO:00308909.6CD38, BCL6, PTPRC
6Notch signaling pathwayGO:00072199.2MYC, CCND1, NOTCH1
7negative regulation of transcription, DNA-templatedGO:00458929.0CD38, CDKN2A, NOTCH1, BCL6
8cellular response to DNA damage stimulusGO:00069748.9BCL6, CCND1, MYC
9response to drugGO:00424938.8ABCB1, MYC, CCND1, CD38
10positive regulation of transcription, DNA-templatedGO:00458938.7MYC, IRF4, NOTCH1, CDKN2A, CD38
11negative regulation of transcription from RNA polymerase II promoterGO:00001228.5MYC, CCND1, BCL6, NOTCH1
12positive regulation of transcription from RNA polymerase II promoterGO:00459448.5MYC, IRF4, NOTCH1, CDKN2A
13transcription, DNA-templatedGO:00063518.1CDKN2A, BCL6, CCND1, IRF4, MYC

Molecular functions related to Plasmablastic Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chromatin DNA bindingGO:00314909.3NOTCH1, BCL6
2protein kinase bindingGO:00199019.2CDKN2A, CCND1, PTPRC
3transcription factor bindingGO:00081348.6CDKN2A, CCND1, IRF4, MYC
4protein bindingGO:00055156.5ABCB1, PTPRC, MYC, IRF4, CCND1, MTOR

Products for genes affiliated with Plasmablastic Lymphoma

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Sources for Plasmablastic Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet