PBL
MCID: PLS025
MIFTS: 38

Plasmablastic Lymphoma (PBL) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Plasmablastic Lymphoma

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Plasmablastic Lymphoma, also known as immunoblastic large-cell lymphoma, is related to chronic lymphocytic leukemia and myeloma. An important gene associated with Plasmablastic Lymphoma is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Cell cycle and Thyroid cancer. The compounds serine and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include b cells, and related mouse phenotypes are tumorigenesis and nervous system.

Aliases & Classifications for Plasmablastic Lymphoma

About this section
Sources:
48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Aliases & Descriptions:

plasmablastic lymphoma 48
immunoblastic large-cell lymphoma 60
pbl 48


External Ids:

SNOMED-CT via Orphanet57 450909005
ICD10 via Orphanet26 C83.3

Related Diseases for Plasmablastic Lymphoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Plasmablastic Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1chronic lymphocytic leukemia30.4CCND1, IGH, CD38, ABCB1, MS4A1, PTPRC
2myeloma30.4BCL6, CCND1, IRF4, MTOR, IGH, MYC
3leukemia30.4CCND1, IRF4, MTOR, IGH, MYC, CDKN2A
4central nervous system lymphoma30.3BCL6
5gastric lymphoma30.3IGH, BCL6
6plasmacytoma30.3IRF4, IGH, MYC, PTPRC, BCL6
7esophageal cancer30.1CDKN2A, CCND1
8t-cell leukemia30.1PTPRC, NOTCH1, MYC, IGH, IRF4
9mantle cell lymphoma30.1CCND1, BCL6
10hodgkin's lymphoma30.0IRF4, IGH, MS4A1, PTPRC, BCL6
11sarcoma30.0MTOR, ABCB1, PTPRC
12rheumatoid arthritis29.9PTPRC
13severe combined immunodeficiency29.9CD38, PTPRC
14myeloid leukemia29.8MYC, CD38, ABCB1, PTPRC
15chronic myeloid leukemia29.8PTPRC, ABCB1, MYC, IRF4
16lung cancer29.8CCND1, MTOR, MYC, CDKN2A, ABCB1, NOTCH1
17squamous cell carcinoma29.8CCND1, MTOR, MYC, CDKN2A, ABCB1, NOTCH1
18orbit lymphoma10.4
19crohn's disease10.4
20liver lymphoma10.3
21spinal cord lymphoma10.3
22diffuse large b-cell lymphoma10.3
23gingivitis10.3
24lymphoma, large-cell, immunoblastic10.3
25bone lymphoma10.2
26lung lymphoma10.2
27small intestine lymphoma10.2
28hepatitis10.2
29adult t-cell leukemia10.1
30cecum lymphoma10.1
31colon lymphoma10.1
32richter's syndrome10.1
33hepatitis c10.1
34orbital cellulitis10.1
35cellulitis10.1
36acquired immunodeficiency syndrome10.1
37hepatitis b10.1
38kaposi's sarcoma10.1
39breast lymphoma10.1
40pediatric lymphoma10.1
41epidermodysplasia verruciformis10.1
42cervicitis10.1
43colonic disease10.1
44esophagitis10.1
45orbital disease10.1
46peritonitis10.1
47rectal disease10.1
48spinal cord disease10.1
49testicular lymphoma10.0BCL6
50rhabdoid tumor10.0PTPRC

Graphical network of the top 20 diseases related to Plasmablastic Lymphoma:



Diseases related to plasmablastic lymphoma

Clinical Features for Plasmablastic Lymphoma

About this section

Drugs & Therapeutics for Plasmablastic Lymphoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Plasmablastic Lymphoma

Drug clinical trials:

Search ClinicalTrials for Plasmablastic Lymphoma

Search NIH Clinical Center for Plasmablastic Lymphoma

Search CenterWatch for Plasmablastic Lymphoma

Genetic Tests for Plasmablastic Lymphoma

About this section

Anatomical Context for Plasmablastic Lymphoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Plasmablastic Lymphoma:

32
B cells

Animal Models for Plasmablastic Lymphoma or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Plasmablastic Lymphoma

About this section

Genetic Variations for Plasmablastic Lymphoma

About this section

Expression for genes affiliated with Plasmablastic Lymphoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Plasmablastic Lymphoma

Search GEO for disease gene expression data for Plasmablastic Lymphoma.

Pathways for genes affiliated with Plasmablastic Lymphoma

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 53Reactome, 52R&D Systems, 49PharmGKB
See all sources

Pathways related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0CDKN2A
29.7MYC, CCND1
39.7MTOR, IRF4
49.6CDKN2A, MYC
59.6CDKN2A, MYC
6
Hide members
9.6MYC, MTOR
79.3NOTCH1, MYC, CCND1
89.3CCND1, MYC, NOTCH1
9
Hide members
9.3IRF4, MYC, CDKN2A
10
Cell cycle Cell cycle (generic schema)
Hide members
9.2CCND1, MYC, CDKN2A
119.2CCND1, MYC, CDKN2A
12
Hide members
9.2CCND1, MYC, CDKN2A
13
Hide members
9.2CDKN2A, MYC, CCND1
14
Hide members
9.2CDKN2A, MYC, CCND1
159.2CCND1, MTOR, MYC
16
Development Prolactin receptor signaling
Hide members
9.2CCND1, MTOR, MYC
179.2CCND1, MTOR, MYC
189.2CCND1, MTOR, MYC
19
Hide members
9.2MYC, MTOR, CCND1
20
Hide members
9.2MYC, MTOR, CCND1
21
Hide members
9.2MYC, MTOR, CCND1
22
Hide members
9.2MYC, MTOR, CCND1
239.1ABCB1, MYC, CCND1
248.7CCND1, MTOR, MYC, CDKN2A
25
Hide members
8.4CCND1, MYC, CDKN2A, BCL6
26
Hide members
8.3MTOR, IGH, PTPRC, BCL6
278.0BCL6, NOTCH1, MYC, MTOR, CCND1
287.7CCND1, MTOR, MYC, CDKN2A, ABCB1, NOTCH1

Compounds for genes affiliated with Plasmablastic Lymphoma

About this section
Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1serine4410.4CCND1
2depsipeptide4410.0CCND1, CDKN2A
3tachyplesin i4410.0CDKN2A, MYC
4pga2449.9CCND1, MYC
5tamoxifen44 49 28 1112.9CCND1, MTOR
6hematoxylin449.8CDKN2A, MS4A1, PTPRC
7farnesylthiosalicylic acid44 2810.7CCND1, MTOR
8cyclopamine44 5910.7MYC, CCND1
9trimetrexate44 1110.7CDKN2A, ABCB1
10roscovitine449.6CCND1, MYC, CDKN2A
11temsirolimus44 1110.6MTOR, ABCB1
12everolimus49 44 1111.6CCND1, MTOR, MYC
13acnu449.6CDKN2A, ABCB1
14melphalan44 1110.4CCND1, MYC, ABCB1
15sirolimus49 1110.4MTOR, ABCB1
16daunorubicin44 49 1111.3ABCB1, CDKN2A, MYC
17erlotinib44 49 1111.3CCND1, MTOR, ABCB1
18sorafenib44 49 1111.3ABCB1, MTOR, CCND1
19n acetylcysteine449.3PTPRC, CDKN2A, MYC, CCND1
20agarose449.2IGH, MYC, CDKN2A, PTPRC
21gefitinib44 49 1111.2ABCB1, MTOR, CCND1
22droloxifene449.2ABCB1, MYC
23paraffin449.1MYC, MS4A1, PTPRC, BCL6
24gemcitabine44 49 1111.1ABCB1, MYC, CCND1
25rapamycin449.1NOTCH1, MYC, MTOR, CCND1
26adriamycin449.0CCND1, MYC, CDKN2A, ABCB1
27rituximab44 49 1111.0MTOR, CD38, MS4A1, BCL6
28tacrolimus44 49 1110.9ABCB1, MYC, MTOR, CCND1
29ly294002448.9NOTCH1, MYC, MTOR, CCND1
30glycogen44 249.9PTPRC, NOTCH1, MYC, MTOR, CCND1
31docetaxel44 49 59 1111.9MTOR, MYC, CDKN2A, ABCB1
32paclitaxel44 49 1110.9CCND1, MYC, CDKN2A, ABCB1
33arsenite44 249.9ABCB1, CDKN2A, MTOR, CCND1
3412-o-tetradecanoylphorbol 13-acetate448.8BCL6, PTPRC, MYC, MTOR
35cyclophosphamide44 49 1110.6BCL6, MS4A1, ABCB1, MTOR
36actinomycin d448.6MYC, CDKN2A, CD38, ABCB1
37phosphatidylinositol448.6CCND1, MTOR, MYC, CD38, NOTCH1, PTPRC
38lipid448.6MTOR, CDKN2A, CD38, NOTCH1, MS4A1, PTPRC
39vegf448.5CCND1, MTOR, MYC, CDKN2A, NOTCH1
40testosterone44 59 11 2411.5CCND1, MTOR, CDKN2A, ABCB1, PTPRC
41cisplatin44 49 59 1111.5CCND1, MTOR, MYC, CDKN2A, ABCB1
42threonine448.5CCND1, MTOR, MYC, CDKN2A, NOTCH1, PTPRC
43vincristine44 49 1110.2CCND1, MYC, CDKN2A, ABCB1, BCL6
44imatinib44 49 1110.2BCL6, ABCB1, MYC, MTOR, CCND1
45dexamethasone44 49 28 1111.0MTOR, MYC, CDKN2A, CD38, ABCB1, NOTCH1
46genistein44 28 59 2 11 2412.9CCND1, MTOR, MYC, CDKN2A, ABCB1, NOTCH1
47tyrosine447.8CCND1, MTOR, MYC, CD38, NOTCH1, PTPRC
48retinoic acid44 248.7CCND1, MTOR, MYC, CDKN2A, CD38, NOTCH1
49estrogen447.7CCND1, MTOR, MYC, CDKN2A, NOTCH1, PTPRC
50doxorubicin44 49 119.4BCL6, CCND1, MTOR, MYC, CDKN2A, ABCB1

GO Terms for genes affiliated with Plasmablastic Lymphoma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:0508539.9PTPRC, CD38
2somatic stem cell divisionGO:0481039.7CDKN2A, NOTCH1
3positive regulation of B cell proliferationGO:0308909.2BCL6, PTPRC, CD38
4negative regulation of cell-matrix adhesionGO:0019539.2BCL6, CDKN2A
5response to drugGO:0424938.9ABCB1, CD38, MYC, CCND1
6positive regulation of transcription, DNA-dependentGO:0458938.9IRF4, MYC, CDKN2A, CD38, NOTCH1
7response to DNA damage stimulusGO:0069748.6BCL6, MYC, CCND1
8negative regulation of transcription, DNA-dependentGO:0458928.5CDKN2A, CD38, NOTCH1, BCL6

Molecular functions related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin DNA bindingGO:0314909.3BCL6, NOTCH1
2protein bindingGO:0055156.0BCL6, CCND1, IRF4, MTOR, MYC, CDKN2A

Products for genes affiliated with Plasmablastic Lymphoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Plasmablastic Lymphoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet