PBL
MCID: PLS025
MIFTS: 52

Plasmablastic Lymphoma (PBL) malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories
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Summaries for Plasmablastic Lymphoma

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MalaCards based summary: Plasmablastic Lymphoma, also known as PBL, is related to chronic lymphocytic leukemia and mantle cell lymphoma. An important gene associated with Plasmablastic Lymphoma is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Interferon type I and Pre-NOTCH Expression and Processing. The compounds temsirolimus and tachyplesin i have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and spinal cord, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Plasmablastic Lymphoma

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42NIH Rare Diseases, 48Orphanet, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Plasmablastic Lymphoma, Aliases & Descriptions:

Name: Plasmablastic Lymphoma 42 48 62
 
Pbl 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


External Ids:

ICD10 via Orphanet26 C83.3
UMLS via Orphanet63 C3472614

Related Diseases for Plasmablastic Lymphoma

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Diseases related to Plasmablastic Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1chronic lymphocytic leukemia30.6CCND1, MS4A1, IGH
2mantle cell lymphoma30.4BCL6, CCND1
3plasmacytoma30.2BCL6, PTPRC, IGH, MYC, IRF4
4hodgkin's lymphoma30.2BCL6, MS4A1, IGH, PTPRC, IRF4
5sarcoma30.0MTOR, PTPRC, ABCB1
6chronic myeloid leukemia29.8ABCB1, PTPRC, MYC, IRF4
7myeloid leukemia29.8PTPRC, MYC, ABCB1, CD38
8t-cell leukemia29.7PTPRC, IGH, MYC, IRF4, NOTCH1
9b-cell lymphomas29.4IGH, PTPRC, MYC, IRF4, MS4A1, CCND1
10follicular lymphoma29.3CCND1, PTPRC, IGH, MYC, IRF4, MS4A1
11glioblastoma29.3CDKN2A, ABCB1, MYC, CCND1, MTOR
12lung cancer28.8CDKN2A, ABCB1, CCND1, MTOR, NOTCH1, MYC
13myeloma28.7MTOR, CCND1, IRF4, MYC, PTPRC, IGH
14leukemia28.3ABCB1, CD38, CDKN2A, NOTCH1, BCL6, CCND1
15testicular lymphoma10.5BCL6
16crohn's disease10.4
17diffuse large b-cell lymphoma10.4
18gastric lymphoma10.4IGH, BCL6
19gingivitis10.4
20lymphosarcoma10.4BCL6, IGH
21hiv-110.3
22hepatitis10.3
23hiv/aids10.3
24lymphoma aidsrelated10.3BCL6, MYC
25angiomyolipoma10.3PTPRC, MTOR
26reticulosarcoma10.2BCL6, IGH, PTPRC
27peripheral t-cell lymphoma10.2BCL6, PTPRC, MS4A1
28anaplastic large cell lymphoma10.2BCL6, PTPRC
29hepatitis b10.1
30hepatitis c10.1
31richter's syndrome10.1
32acquired immunodeficiency syndrome10.1
33epidermodysplasia verruciformis10.1
34kaposi's sarcoma10.1
35duodenitis10.1
36orbital cellulitis10.1
37cellulitis10.1
38cervicitis10.1
39esophagitis10.1
40peritonitis10.1
41rectal disease10.1
42castleman's disease10.1
43essential thrombocythemia10.1
44primary effusion lymphoma10.1
45hepatitis c virus10.1
46hepatitis b virus infection10.1
47immunodeficiency with hyper igm type 210.1BCL6, PTPRC, CD38
48burkitt's lymphoma10.1BCL6, CCND1
49malignant peripheral nerve sheath tumor10.1CDKN2A, ABCB1
50polycystic kidney disease, autosomal dominant10.1MYC, MTOR

Graphical network of the top 20 diseases related to Plasmablastic Lymphoma:



Diseases related to plasmablastic lymphoma

Symptoms for Plasmablastic Lymphoma

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Drugs & Therapeutics for Plasmablastic Lymphoma

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Drug clinical trials:

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Search NIH Clinical Center for Plasmablastic Lymphoma

Genetic Tests for Plasmablastic Lymphoma

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Anatomical Context for Plasmablastic Lymphoma

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MalaCards organs/tissues related to Plasmablastic Lymphoma:

32
B cells, Bone, Spinal cord, Liver, Lymph node, Small intestine, Lung, Breast, Skin, Testes, Bone marrow, Colon, Uterus, Testis, Cervix

Animal Models for Plasmablastic Lymphoma or affiliated genes

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Publications for Plasmablastic Lymphoma

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Articles related to Plasmablastic Lymphoma:

(show top 50)    (show all 200)
idTitleAuthorsYear
1
Manifestations of gastrointestinal plasmablastic lymphoma: a case series with literature review. (25206297)
2014
2
Extensive maxillofacial plasmablastic lymphoma in an immunocompetent patient. (25103486)
2014
3
Extraoral plasmablastic lymphoma detected using ascitic fluid cytology and flow cytometry: a case report with a review of the literature. (24685599)
2014
4
CD20-positive plasmablastic lymphoma with excellent response to bortezomib combined with rituximab. (24528507)
2014
5
Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation. (24349055)
2013
6
Brentuximab vedotin demonstrates activity in a patient with plasmablastic lymphoma arising from a background of chronic lymphocytic leukemia. (23509308)
2013
7
An uncommon case of epidural plasmablastic lymphoma presents as spinal cord compression. (23993656)
2013
8
Primary cutaneous plasmablastic lymphoma in an immunocompetent patient. (24124865)
2013
9
Bortezomib in plasmablastic lymphoma: a case report and review of the literature. (23689224)
2013
10
Multifocal cranial plasmablastic lymphoma as a rare manifestation of posttransplant lymphoproliferative disorder. (22976265)
2012
11
Quantification of plasma Epstein-Barr virus DNA for assessing treatment response in a patient with plasmablastic lymphoma. (21881823)
2012
12
Lack and/or aberrant localization of major histocompatibility class II (MHCII) protein in plasmablastic lymphoma. (22689685)
2012
13
Plasmablastic Lymphoma presenting as small intestinal polyposis: A case-report. (23285420)
2012
14
Unusual presentation of gastric plasmablastic lymphoma in HIV-negative patient. (21476144)
2012
15
Plasmablastic lymphoma of the retroperitoneum in an HIV- and HCV-positive patient: hard to diagnose and harder to treat. (22562157)
2012
16
Oral and extraoral plasmablastic lymphoma: similarities and differences in clinicopathologic characteristics. (21571968)
2011
17
Oral plasmablastic lymphoma: a case report. (21884151)
2011
18
Uniform expression of Notch1, suppressor of B-cell-specific gene expression, in plasmablastic lymphoma. (21631271)
2011
19
Surgical resection of small bowel plasmablastic lymphoma for chronic bleeding. (21944334)
2011
20
Interesting image. Assessment of plasmablastic lymphoma by F-18 FDG PET/CT: case report. (20940549)
2010
21
Plasmablastic lymphoma with MYC translocation: evidence for a common pathway in the generation of plasmablastic features. (20348882)
2010
22
Plasmablastic lymphoma in a human immunodeficiency virus negative patient. (20551562)
2010
23
Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement. (21088162)
2010
24
Diagnosis and treatment of myelo-osteolytic plasmablastic lymphoma of the femur in a domestic ferret. (20707751)
2010
25
Plasmablastic lymphoma in the anal canal. (19809569)
2009
26
Plasmablastic lymphoma in an immunocompetent patient. (19581534)
2009
27
Multifocal cutaneous and systemic plasmablastic lymphoma in an infant with combined living donor small bowel and liver transplant. (19067927)
2009
28
Cutaneous nodules as diagnostic key of an extraoral plasmablastic lymphoma in an human immunodeficiency virus-infected patient. (18028356)
2008
29
Plasmablastic lymphoma involving breast: a case diagnosed by fine-needle aspiration and core needle biopsy. (18335555)
2008
30
Sonographic appearance of plasmablastic lymphoma of the testes. (18499857)
2008
31
Plasmablastic lymphoma mimicking orbital cellulitis. (18597126)
2008
32
EBV detection in HIV-related oral plasmablastic lymphoma. (17944673)
2007
33
Images in HIV/AIDS. Oral plasmablastic lymphoma. (17902226)
2007
34
Extranodal plasmablastic lymphoma arising in mantle cell lymphoma. (17903200)
2007
35
Plasmablastic lymphoma of head and neck: report of two new cases and correlation with c-myc and IgVH gene mutation status. (20614267)
2007
36
Editorial comment: plasmablastic lymphoma--a diagnostic and therapeutic puzzle. (17902227)
2007
37
Plasmablastic lymphoma of visceral cranium, cervix and thorax in an HIV-negative woman. (17361427)
2007
38
Extra-oral plasmablastic lymphoma: report of a case and review of literature. (16938530)
2006
39
Incidental oral plasmablastic lymphoma with aberrant expression of CD4 in an elderly HIV-negative patient: how a gingival polyp can cause confusion. (15720425)
2005
40
Cytologic features of plasmablastic lymphoma. (15803491)
2005
41
Improved outcome of human immunodeficiency virus-associated plasmablastic lymphoma of the oral cavity in the era of highly active antiretroviral therapy: a report of two cases. (15223650)
2004
42
Cutaneous plasmablastic lymphoma in an HIV-positive male: an unrecognized cutaneous manifestation. (15118393)
2004
43
Plasmablastic lymphoma of the cervical lymph nodes in a human immunodeficiency virus-negative patient: a case report and review of the literature. (15086296)
2004
44
Plasmablastic lymphoma presenting in a human immunodeficiency virus-negative patient: a case report. (12783213)
2003
45
Plasmablastic lymphoma of the oral cavity and jaws. (12351965)
2002
46
Molecular histogenesis of plasmablastic lymphoma of the oral cavity. (12437635)
2002
47
Plasmablastic lymphoma of the lung: report of a unique case and review of the literature. (11175653)
2001
48
HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. (10666218)
2000
49
Plasmablastic lymphoma of the stomach. A case report. (9542326)
1998
50
Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. (9028965)
1997

Variations for Plasmablastic Lymphoma

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Expression for genes affiliated with Plasmablastic Lymphoma

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Expression patterns in normal tissues for genes affiliated with Plasmablastic Lymphoma

Search GEO for disease gene expression data for Plasmablastic Lymphoma.

Pathways for genes affiliated with Plasmablastic Lymphoma

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Pathways related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MTOR, PTPRC
2
Show member pathways
9.6NOTCH1, CCND1
39.5MTOR, MYC
49.5MYC, MTOR
59.4MYC, CDKN2A
6
Show member pathways
9.4MYC, CDKN2A
79.3MYC, CCND1
89.3CCND1, MYC
99.3CCND1, MYC
109.3CCND1, MYC
119.3BCL6, MTOR, IRF4
12
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.2CDKN2A, IRF4, MYC
13
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.0MTOR, CCND1, MYC
14
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.0MTOR, CCND1, MYC
15
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.0MTOR, CCND1, MYC
16
Show member pathways
Signal transduction PTEN pathway60
9.0MTOR, CCND1, MYC
179.0MTOR, CCND1, MYC
189.0MYC, CCND1, MTOR
19
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.0MYC, CCND1, MTOR
209.0MYC, CCND1, MTOR
21
Show member pathways
Notch signaling pathway37
9.0NOTCH1, CCND1, MYC
229.0MYC, CCND1, NOTCH1
23
Show member pathways
9.0MYC, CCND1, NOTCH1
248.9CDKN2A, CCND1, MYC
25
Show member pathways
8.9CDKN2A, CCND1, MYC
268.9MYC, CCND1, CDKN2A
27
Show member pathways
Cell cycle37
8.9MYC, CCND1, CDKN2A
28
Show member pathways
8.9MYC, CCND1, CDKN2A
29
Show member pathways
DNA damage response37
8.9MYC, CCND1, CDKN2A
308.9CCND1, MYC, ABCB1
31
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
8.8IGH, PTPRC, BCL6
328.6NOTCH1, MTOR, CCND1, MYC
33
Show member pathways
Signaling Pathways in Glioblastoma37
8.6CDKN2A, MTOR, CCND1, MYC
348.6CDKN2A, MTOR, CCND1, MYC
35
Show member pathways
8.5CDKN2A, NOTCH1, CCND1, MYC
36
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
8.4MYC, CCND1, BCL6, CDKN2A
37
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
8.2IGH, MYC, CCND1, MTOR
388.1NOTCH1, BCL6, MTOR, CCND1, MYC
397.7ABCB1, MYC, CCND1, MTOR, NOTCH1, CDKN2A

Compounds for genes affiliated with Plasmablastic Lymphoma

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Compounds related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1temsirolimus44 1110.9ABCB1, MTOR
2tachyplesin i449.8CDKN2A, MYC
3hematoxylin449.8MS4A1, CDKN2A, PTPRC
4trimetrexate44 1110.8ABCB1, CDKN2A
5farnesylthiosalicylic acid28 4410.7CCND1, MTOR
6acnu449.6CDKN2A, ABCB1
7erlotinib44 50 1111.5ABCB1, CCND1, MTOR
8sorafenib44 50 1111.5CCND1, MTOR, ABCB1
9rituximab44 50 1111.5CD38, BCL6, MS4A1, MTOR
10everolimus44 50 1111.4MTOR, CCND1, MYC
11gefitinib44 50 1111.4MTOR, CCND1, ABCB1
12roscovitine449.3CDKN2A, CCND1, MYC
13cyclophosphamide44 50 1111.3ABCB1, MS4A1, MTOR, BCL6
14daunorubicin44 50 1111.3MYC, CDKN2A, ABCB1
15pga2449.2MYC, CCND1
16melphalan44 50 1111.2ABCB1, CCND1, MYC
17docetaxel44 50 61 1112.0ABCB1, CDKN2A, MTOR, MYC
1812-o-tetradecanoylphorbol 13-acetate449.0PTPRC, MTOR, MYC, BCL6
19gemcitabine44 50 1111.0ABCB1, CCND1, MYC
20n acetylcysteine448.9MYC, CDKN2A, CCND1, PTPRC
21tacrolimus44 50 1110.9MTOR, MYC, ABCB1, CCND1
22depsipeptide448.9ABCB1, MYC, CCND1, CDKN2A
23actinomycin d448.9CD38, CDKN2A, MYC, ABCB1
24adriamycin448.9ABCB1, CCND1, CDKN2A, MYC
25rapamycin448.9CCND1, MTOR, NOTCH1, MYC
26ly294002448.9MTOR, MYC, CCND1, NOTCH1
27tamoxifen44 50 28 1111.9CCND1, MTOR, MYC, ABCB1
28lipid448.8MTOR, NOTCH1, MS4A1, CD38, PTPRC, CDKN2A
29testosterone44 61 24 1111.8ABCB1, MTOR, CDKN2A, CCND1, PTPRC
30lovastatin44 50 61 28 1112.8CCND1, CDKN2A, ABCB1
31paclitaxel44 50 1110.8ABCB1, CDKN2A, CCND1, MYC
32cyclosporin a44 28 6110.7ABCB1, PTPRC, MYC, MTOR
33glycogen44 249.7MYC, CCND1, MTOR, NOTCH1, PTPRC
34agarose448.7MYC, PTPRC, IGH, CDKN2A
35arsenite44 249.6MYC, CCND1, MTOR, CDKN2A, ABCB1
36cisplatin44 50 61 1111.5CCND1, MYC, CDKN2A, ABCB1, MTOR
37vegf448.5NOTCH1, CCND1, MYC, CDKN2A, MTOR
38cycloheximide448.5MYC, CCND1, BCL6, CDKN2A, PTPRC
39imatinib44 50 1110.4BCL6, MTOR, CCND1, MYC, ABCB1
40phosphatidylinositol448.4PTPRC, MYC, MTOR, CD38, NOTCH1, CCND1
41vincristine44 50 1110.4ABCB1, MYC, CDKN2A, BCL6, CCND1
42threonine448.3PTPRC, CCND1, MYC, CDKN2A, MTOR, NOTCH1
43paraffin448.3MS4A1, CCND1, BCL6, PTPRC, MYC, CDKN2A
44dexamethasone44 50 28 1111.1MTOR, CD38, CDKN2A, NOTCH1, MYC, ABCB1
45genistein44 28 61 2 24 1112.9CCND1, PTPRC, MYC, MTOR, NOTCH1, CDKN2A
46tyrosine447.9BCL6, MTOR, CD38, CCND1, PTPRC, MYC
47retinoic acid44 248.8MYC, CCND1, NOTCH1, MTOR, BCL6, CD38
48estrogen447.8CCND1, NOTCH1, MTOR, MYC, PTPRC, CDKN2A
49serine447.8CCND1, PTPRC, MYC, MTOR, CDKN2A, NOTCH1
50doxorubicin44 50 119.7CCND1, ABCB1, CDKN2A, MYC, MTOR, BCL6

GO Terms for genes affiliated with Plasmablastic Lymphoma

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Cellular components related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:0160208.9CD38, MTOR, CCND1, ABCB1

Biological processes related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1somatic stem cell divisionGO:0481039.9CDKN2A, NOTCH1
2B cell receptor signaling pathwayGO:0508539.9PTPRC, CD38
3B cell proliferationGO:0421009.8PTPRC, MS4A1
4negative regulation of cell-matrix adhesionGO:0019539.7BCL6, CDKN2A
5positive regulation of B cell proliferationGO:0308909.6CD38, BCL6, PTPRC
6Notch signaling pathwayGO:0072199.2MYC, CCND1, NOTCH1
7negative regulation of transcription, DNA-templatedGO:0458929.0CD38, CDKN2A, NOTCH1, BCL6
8cellular response to DNA damage stimulusGO:0069748.9BCL6, CCND1, MYC
9response to drugGO:0424938.8ABCB1, MYC, CCND1, CD38
10positive regulation of transcription, DNA-templatedGO:0458938.7MYC, IRF4, NOTCH1, CDKN2A, CD38
11negative regulation of transcription from RNA polymerase II promoterGO:0001228.5MYC, CCND1, BCL6, NOTCH1
12positive regulation of transcription from RNA polymerase II promoterGO:0459448.5MYC, IRF4, NOTCH1, CDKN2A
13transcription, DNA-templatedGO:0063518.1CDKN2A, BCL6, CCND1, IRF4, MYC

Molecular functions related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin DNA bindingGO:0314909.3NOTCH1, BCL6
2protein kinase bindingGO:0199019.2CDKN2A, CCND1, PTPRC
3transcription factor bindingGO:0081348.6CDKN2A, CCND1, IRF4, MYC
4protein bindingGO:0055156.5ABCB1, PTPRC, MYC, IRF4, CCND1, MTOR

Products for genes affiliated with Plasmablastic Lymphoma

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Sources for Plasmablastic Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet