PBL
MCID: PLS025
MIFTS: 38

Plasmablastic Lymphoma (PBL) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Plasmablastic Lymphoma

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32MalaCards
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MalaCards: Plasmablastic Lymphoma, also known as immunoblastic large-cell lymphoma, is related to chronic lymphocytic leukemia and myeloma. An important gene associated with Plasmablastic Lymphoma is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Cell cycle and Thyroid cancer. The compounds serine and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include b cells, and related mouse phenotypes are tumorigenesis and nervous system.

Aliases & Classifications for Plasmablastic Lymphoma

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48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Aliases & Descriptions:

plasmablastic lymphoma 48
immunoblastic large-cell lymphoma 60
pbl 48


External Ids:

SNOMED-CT via Orphanet57 450909005
ICD10 via Orphanet26 C83.3

Related Diseases for Plasmablastic Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Plasmablastic Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1chronic lymphocytic leukemia30.4CCND1, IGH, CD38, ABCB1, MS4A1, PTPRC
2myeloma30.4BCL6, CCND1, IRF4, MTOR, IGH, MYC
3leukemia30.4CCND1, IRF4, MTOR, IGH, MYC, CDKN2A
4central nervous system lymphoma30.3BCL6
5gastric lymphoma30.3IGH, BCL6
6plasmacytoma30.3IRF4, IGH, MYC, PTPRC, BCL6
7esophageal cancer30.1CDKN2A, CCND1
8t-cell leukemia30.1PTPRC, NOTCH1, MYC, IGH, IRF4
9mantle cell lymphoma30.1CCND1, BCL6
10hodgkin's lymphoma30.0IRF4, IGH, MS4A1, PTPRC, BCL6
11sarcoma30.0MTOR, ABCB1, PTPRC
12rheumatoid arthritis29.9PTPRC
13severe combined immunodeficiency29.9CD38, PTPRC
14myeloid leukemia29.8MYC, CD38, ABCB1, PTPRC
15chronic myeloid leukemia29.8PTPRC, ABCB1, MYC, IRF4
16lung cancer29.8CCND1, MTOR, MYC, CDKN2A, ABCB1, NOTCH1
17squamous cell carcinoma29.8CCND1, MTOR, MYC, CDKN2A, ABCB1, NOTCH1
18orbit lymphoma10.4
19crohn's disease10.4
20liver lymphoma10.3
21spinal cord lymphoma10.3
22diffuse large b-cell lymphoma10.3
23gingivitis10.3
24lymphoma, large-cell, immunoblastic10.3
25bone lymphoma10.2
26lung lymphoma10.2
27small intestine lymphoma10.2
28hepatitis10.2
29adult t-cell leukemia10.1
30cecum lymphoma10.1
31colon lymphoma10.1
32richter's syndrome10.1
33hepatitis c10.1
34orbital cellulitis10.1
35cellulitis10.1
36acquired immunodeficiency syndrome10.1
37hepatitis b10.1
38kaposi's sarcoma10.1
39breast lymphoma10.1
40pediatric lymphoma10.1
41epidermodysplasia verruciformis10.1
42cervicitis10.1
43colonic disease10.1
44esophagitis10.1
45orbital disease10.1
46peritonitis10.1
47rectal disease10.1
48spinal cord disease10.1
49testicular lymphoma10.0BCL6
50rhabdoid tumor10.0PTPRC

Graphical network of the top 20 diseases related to Plasmablastic Lymphoma:



Diseases related to plasmablastic lymphoma

Clinical Features for Plasmablastic Lymphoma

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Drugs & Therapeutics for Plasmablastic Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Plasmablastic Lymphoma

Drug clinical trials:

Search ClinicalTrials for Plasmablastic Lymphoma

Search NIH Clinical Center for Plasmablastic Lymphoma

Search CenterWatch for Plasmablastic Lymphoma

Genetic Tests for Plasmablastic Lymphoma

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Anatomical Context for Plasmablastic Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Plasmablastic Lymphoma:

32
B cells

Animal Models for Plasmablastic Lymphoma or affiliated genes

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36MGI
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Publications for Plasmablastic Lymphoma

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Genetic Variations for Plasmablastic Lymphoma

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Expression for genes affiliated with Plasmablastic Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plasmablastic Lymphoma

Search GEO for disease gene expression data for Plasmablastic Lymphoma.

Pathways for genes affiliated with Plasmablastic Lymphoma

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Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 53Reactome, 52R&D Systems, 49PharmGKB
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Pathways related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0CDKN2A
29.7MYC, CCND1
39.7MTOR, IRF4
49.6CDKN2A, MYC
59.6CDKN2A, MYC
6
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9.6MYC, MTOR
79.3NOTCH1, MYC, CCND1
89.3CCND1, MYC, NOTCH1
9
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9.3IRF4, MYC, CDKN2A
10
Cell cycle Cell cycle (generic schema)
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9.2CCND1, MYC, CDKN2A
119.2CCND1, MYC, CDKN2A
12
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9.2CCND1, MYC, CDKN2A
13
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9.2CDKN2A, MYC, CCND1
14
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9.2CDKN2A, MYC, CCND1
159.2CCND1, MTOR, MYC
16
Development Prolactin receptor signaling
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9.2CCND1, MTOR, MYC
179.2CCND1, MTOR, MYC
189.2CCND1, MTOR, MYC
19
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9.2MYC, MTOR, CCND1
20
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9.2MYC, MTOR, CCND1
21
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9.2MYC, MTOR, CCND1
22
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9.2MYC, MTOR, CCND1
239.1ABCB1, MYC, CCND1
248.7CCND1, MTOR, MYC, CDKN2A
25
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8.4CCND1, MYC, CDKN2A, BCL6
26
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8.3MTOR, IGH, PTPRC, BCL6
278.0BCL6, NOTCH1, MYC, MTOR, CCND1
287.7CCND1, MTOR, MYC, CDKN2A, ABCB1, NOTCH1

Compounds for genes affiliated with Plasmablastic Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1serine4410.4CCND1
2depsipeptide4410.0CCND1, CDKN2A
3tachyplesin i4410.0MYC, CDKN2A
4pga2449.9MYC, CCND1
5tamoxifen44 49 28 1112.9MTOR, CCND1
6farnesylthiosalicylic acid44 2810.8CCND1, MTOR
7hematoxylin449.8MS4A1, CDKN2A, PTPRC
8trimetrexate44 1110.7ABCB1, CDKN2A
9roscovitine449.6CCND1, CDKN2A, MYC
10temsirolimus44 1110.6MTOR, ABCB1
11everolimus49 44 1111.6MTOR, CCND1, MYC
12acnu449.6CDKN2A, ABCB1
13droloxifene449.5MYC, ABCB1
14melphalan44 1110.4MYC, CCND1, ABCB1
15sirolimus49 1110.4ABCB1, MTOR
16cyclopamine44 5910.4MYC, CCND1
17daunorubicin44 49 1111.3MYC, CDKN2A, ABCB1
18erlotinib44 49 1111.3MTOR, ABCB1, CCND1
19sorafenib44 49 1111.3MTOR, CCND1, ABCB1
20n acetylcysteine449.3MYC, CCND1, PTPRC, CDKN2A
21agarose449.2IGH, CDKN2A, PTPRC, MYC
22gefitinib44 49 1111.2MTOR, CCND1, ABCB1
23paraffin449.1PTPRC, BCL6, MS4A1, MYC
24gemcitabine44 49 1111.1MYC, CCND1, ABCB1
25rapamycin449.1MTOR, MYC, CCND1, NOTCH1
26adriamycin449.0ABCB1, CCND1, MYC, CDKN2A
27rituximab44 49 1111.0MS4A1, CD38, MTOR, BCL6
28tacrolimus44 49 1110.9MTOR, CCND1, ABCB1, MYC
29ly294002448.9CCND1, MTOR, NOTCH1, MYC
30glycogen44 249.9PTPRC, NOTCH1, CCND1, MYC, MTOR
31docetaxel44 49 59 1111.9ABCB1, MTOR, MYC, CDKN2A
32paclitaxel44 49 1110.9ABCB1, CDKN2A, CCND1, MYC
33arsenite44 249.9CDKN2A, ABCB1, MTOR, CCND1
3412-o-tetradecanoylphorbol 13-acetate448.8MTOR, BCL6, PTPRC, MYC
35cyclophosphamide44 49 1110.6MS4A1, BCL6, ABCB1, MTOR
36actinomycin d448.6CD38, CDKN2A, MYC, ABCB1
37phosphatidylinositol448.6CCND1, MTOR, MYC, CD38, PTPRC, NOTCH1
38lipid448.6MS4A1, PTPRC, NOTCH1, CD38, CDKN2A, MTOR
39vegf448.5CCND1, MTOR, CDKN2A, NOTCH1, MYC
40testosterone44 59 11 2411.5CCND1, CDKN2A, ABCB1, PTPRC, MTOR
41cisplatin44 49 59 1111.5ABCB1, CDKN2A, MYC, MTOR, CCND1
42threonine448.5MTOR, NOTCH1, CDKN2A, PTPRC, MYC, CCND1
43vincristine44 49 1110.2BCL6, CCND1, MYC, CDKN2A, ABCB1
44imatinib44 49 1110.2MYC, ABCB1, BCL6, MTOR, CCND1
45dexamethasone44 49 28 1111.0MTOR, PTPRC, ABCB1, MYC, CDKN2A, NOTCH1
46genistein44 28 59 2 11 2412.9MTOR, MYC, CCND1, CDKN2A, ABCB1, PTPRC
47tyrosine447.8CD38, NOTCH1, MTOR, PTPRC, MYC, CCND1
48retinoic acid44 248.7CDKN2A, NOTCH1, CD38, MYC, MTOR, CCND1
49estrogen447.7MYC, CCND1, MTOR, CDKN2A, BCL6, PTPRC
50doxorubicin44 49 119.4ABCB1, BCL6, NOTCH1, CCND1, CDKN2A, MTOR

GO Terms for genes affiliated with Plasmablastic Lymphoma

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16Gene Ontology
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Biological processes related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:0508539.9PTPRC, CD38
2somatic stem cell divisionGO:0481039.7CDKN2A, NOTCH1
3positive regulation of B cell proliferationGO:0308909.2BCL6, PTPRC, CD38
4negative regulation of cell-matrix adhesionGO:0019539.2BCL6, CDKN2A
5response to drugGO:0424938.9ABCB1, CD38, MYC, CCND1
6positive regulation of transcription, DNA-dependentGO:0458938.9IRF4, MYC, CDKN2A, CD38, NOTCH1
7response to DNA damage stimulusGO:0069748.6BCL6, MYC, CCND1
8negative regulation of transcription, DNA-dependentGO:0458928.5CDKN2A, CD38, NOTCH1, BCL6

Molecular functions related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin DNA bindingGO:0314909.3BCL6, NOTCH1
2protein bindingGO:0055156.0BCL6, CCND1, IRF4, MTOR, MYC, CDKN2A

Products for genes affiliated with Plasmablastic Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Plasmablastic Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet