PBL
MCID: PLS025
MIFTS: 45

Plasmablastic Lymphoma (PBL) malady

Blood, Cancer, Immune categories

Summaries for Plasmablastic Lymphoma

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33MalaCards
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MalaCards: Plasmablastic Lymphoma, also known as immunoblastic large-cell lymphoma, is related to lymphoma, diffuse large cell and central nervous system lymphoma. An important gene associated with Plasmablastic Lymphoma is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Cell cycle and Thyroid cancer. The compounds serine and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are tumorigenesis and nervous system.

Aliases & Classifications for Plasmablastic Lymphoma

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Aliases & Descriptions:

plasmablastic lymphoma 49
immunoblastic large-cell lymphoma 61
pbl 49


External Ids:

ICD10 via Orphanet26 C83.3

Related Diseases for Plasmablastic Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Plasmablastic Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma, diffuse large cell30.4BCL6, PTPRC, MS4A1, MYC
2central nervous system lymphoma30.3BCL6
3gastric lymphoma30.3IGH, BCL6
4plasma cell leukemia30.1CCND1
5mantle cell lymphoma30.1CCND1, BCL6
6b-cell chronic lymphocytic leukemia30.1MS4A1, IGH, CCND1
7t-cell leukemia30.1PTPRC, NOTCH1, MYC, IGH, IRF4
8follicular lymphoma30.1CCND1, IRF4, IGH, MYC, MS4A1, PTPRC
9chronic myeloid leukemia29.9PTPRC, ABCB1, MYC, IRF4
10squamous cell carcinoma29.9CCND1, MTOR, MYC, CDKN2A, ABCB1, NOTCH1
11orbit lymphoma10.4
12lymphoma, large-cell, immunoblastic10.4
13liver lymphoma10.3
14spinal cord lymphoma10.3
15bone lymphoma10.2
16lung lymphoma10.2
17central nervous system lymphoma, primary10.2
18crohn's disease10.1
19cecum lymphoma10.1
20colon lymphoma10.1
21richter's syndrome10.1
22hepatitis c10.1
23hepatitis e10.1
24orbital cellulitis10.1
25cellulitis10.1
26acquired immunodeficiency syndrome10.1
27hepatitis d10.1
28kaposi's sarcoma10.1
29breast lymphoma10.1
30pediatric lymphoma10.1
31n syndrome10.1
32small intestine lymphoma10.1
33epidermodysplasia verruciformis10.1
34spinal cord disease10.1
35primary effusion lymphoma10.1
36castleman's disease10.1
37leukemia, b-cell, chronic10.1
38leukemia, t-cell, chronic10.1
39essential thrombocythemia10.1
40oral cancer10.1
41leukemia/lymphoma, t-cell10.1
42hepatitis c virus10.1
43parkinson's disease10.0
44arthritis10.0
45toxoplasmosis10.0
46esophageal squamous cell carcinoma10.0
47testicular lymphoma10.0BCL6
48rhabdoid tumor10.0PTPRC
49asthma10.0CD38
50neuroblastoma10.0MYC

Graphical network of the top 20 diseases related to Plasmablastic Lymphoma:



Diseases related to plasmablastic lymphoma

Clinical Features for Plasmablastic Lymphoma

Drugs & Therapeutics for Plasmablastic Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Plasmablastic Lymphoma

Drug clinical trials:

Search ClinicalTrials for Plasmablastic Lymphoma

Search NIH Clinical Center for Plasmablastic Lymphoma

Search CenterWatch for Plasmablastic Lymphoma

Genetic Tests for Plasmablastic Lymphoma

Anatomical Context for Plasmablastic Lymphoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Plasmablastic Lymphoma:

33
Bone marrow, Lymph node, Spleen, Spinal cord, Small intestine, Colon, Liver, Lung, Breast, Skin, Uterus, Testis, Cervix, T cells, B cells

Animal Models for Plasmablastic Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Plasmablastic Lymphoma

Sources:
51PubMed
See all sources

Articles related to Plasmablastic Lymphoma:

(show top 50)    (show all 192)
idTitleAuthorsYear
1
Plasmablastic lymphoma of the oral cavity in a human immunodeficiency virus-negative patient: A case report with literature review. (23791544)
2014
2
Brentuximab vedotin demonstrates activity in a patient with plasmablastic lymphoma arising from a background of chronic lymphocytic leukemia. (23509308)
2013
3
Bortezomib in plasmablastic lymphoma: a case report and review of the literature. (23689224)
2013
4
A case of plasmablastic lymphoma diagnosed on liquid-based pap test. (24273019)
2013
5
Cutaneous plasmablastic lymphoma in an immunocompetent patient with long-term pyrimethamine use for essential thrombocythemia: a case report and literature review. (23476834)
2013
6
Plasmablastic lymphoma following transplantation. (23543973)
2013
7
Post-transplant plasmablastic lymphoma of the skin. (22897322)
2013
8
Oral plasmablastic lymphoma in an HIV-positive patient with an unusual survival rate. (22653612)
2013
9
Plasmablastic lymphoma after standard-dose temozolomide for newly diagnosed glioblastoma. (23685934)
2013
10
Plasmablastic lymphoma versus anaplastic myeloma in a human immunodeficiency virus negative male: a diagnostic quandary. (24093145)
2013
11
Poor outcome of HIV-infected patients with plasmablastic lymphoma: results from the German AIDS-related lymphoma cohort study. (23574794)
2013
12
Multifocal cranial plasmablastic lymphoma as a rare manifestation of posttransplant lymphoproliferative disorder. (22976265)
2012
13
Plasmablastic Lymphoma presenting as small intestinal polyposis: A case-report. (23285420)
2012
14
Plasmablastic lymphoma in an elderly immunocompetent patient. (22524665)
2012
15
Plasmablastic lymphoma of the stomach in an HIV-negative patient. (23121609)
2012
16
Oral and extraoral plasmablastic lymphoma: similarities and differences in clinicopathologic characteristics. (21571968)
2011
17
Case of relapsed AIDS-related plasmablastic lymphoma treated with autologous stem cell transplantation and highly active antiretroviral therapy. (21464873)
2011
18
Dominant genetic aberrations and coexistent EBV infection in HIV-related oral plasmablastic lymphomas. (21783402)
2011
19
Identification of loss of p16 expression and upregulation of MDR-1 as genetic events resulting from two novel chromosomal translocations found in a plasmablastic lymphoma of the uterus. (21325069)
2011
20
Plasmablastic lymphoma of the cecum: report of a case with cytologic findings. (20607680)
2011
21
Primary leptomeningeal plasmablastic lymphoma. (21359853)
2011
22
Plasmablastic lymphoma associated to Crohn's disease and hepatitis C virus chronic infection. (22115386)
2011
23
Plasmablastic lymphoma: are more intensive regimens needed? (21788074)
2011
24
Plasmablastic lymphoma with MYC translocation: evidence for a common pathway in the generation of plasmablastic features. (20348882)
2010
25
Diagnosis and treatment of myelo-osteolytic plasmablastic lymphoma of the femur in a domestic ferret. (20707751)
2010
26
Prognostic factors in chemotherapy-treated patients with HIV-associated Plasmablastic lymphoma. (20167839)
2010
27
Patient with HIV-associated plasmablastic lymphoma responding to bortezomib alone and in combination with dexamethasone, gemcitabine, oxaliplatin, cytarabine, and pegfilgrastim chemotherapy and lenalidomide alone. (20823416)
2010
28
Plasmablastic plasma cell myeloma mimicking plasmablastic lymphoma. (21253422)
2010
29
Plasmablastic lymphoma of the oral cavity: a review. (20138565)
2010
30
CD3- and CD4-positive plasmablastic lymphoma: a literature review of Japanese plasmablastic lymphoma cases. (20720363)
2010
31
Plasmablastic lymphoma in the anal canal. (19809569)
2009
32
Plasmablastic lymphoma of the oral cavity in an HIV-positive patient: a case report and review of literature. (19443181)
2009
33
Plasmablastic lymphoma: a review. (18939960)
2009
34
Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma. (19909553)
2009
35
Plasmablastic lymphoma involving breast: a case diagnosed by fine-needle aspiration and core needle biopsy. (18335555)
2008
36
Plasmablastic lymphoma in the orbit: case report. (18569836)
2008
37
Plasmablastic lymphoma with small lymphocytic lymphoma: clinico-pathologic features, and review of the literature. (18720210)
2008
38
HHV8 in plasmablastic lymphoma. (18162787)
2008
39
Editorial comment: plasmablastic lymphoma--a diagnostic and therapeutic puzzle. (17902227)
2007
40
Prolonged survival of an HIV-infected patient with plasmablastic lymphoma of the oral cavity. (17094093)
2007
41
AIDS-associated plasmablastic lymphoma presenting at the insertion site of a peritoneal dialysis catheter. (17634499)
2007
42
Extra-oral plasmablastic lymphoma: report of a case and review of literature. (16938530)
2006
43
KSHV/HHV8-associated primary cutaneous plasmablastic lymphoma in a patient with Castleman's disease and Kaposi's sarcoma. (16972955)
2006
44
Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm. (16327436)
2005
45
Tissue inhibitor of metalloproteinase 1 (TIMP-1) promotes plasmablastic differentiation of a Burkitt lymphoma cell line: implications in the pathogenesis of plasmacytic/plasmablastic tumors. (15479729)
2005
46
Oral plasmablastic lymphoma in an HIV-negative patient: a case report and review of the literature. (16037778)
2005
47
Plasmablastic lymphoma of the cervical lymph nodes in a human immunodeficiency virus-negative patient: a case report and review of the literature. (15086296)
2004
48
Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts. (12531789)
2003
49
Plasmablastic lymphoma of the lung: report of a unique case and review of the literature. (11175653)
2001
50
Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. (9028965)
1997

Genetic Variations for Plasmablastic Lymphoma

Expression for genes affiliated with Plasmablastic Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Plasmablastic Lymphoma

Search GEO for disease gene expression data for Plasmablastic Lymphoma.

Pathways for genes affiliated with Plasmablastic Lymphoma

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 54Reactome, 53R&D Systems, 50PharmGKB
See all sources

Pathways related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0CDKN2A
29.7MYC, CCND1
39.7MTOR, IRF4
49.6CDKN2A, MYC
59.6CDKN2A, MYC
6
Hide members
9.6MYC, MTOR
79.3NOTCH1, MYC, CCND1
89.3CCND1, MYC, NOTCH1
9
Hide members
9.3IRF4, MYC, CDKN2A
10
Cell cycle Cell cycle (generic schema)
Hide members
9.2CCND1, MYC, CDKN2A
119.2CCND1, MYC, CDKN2A
12
Hide members
9.2CCND1, MYC, CDKN2A
13
Hide members
9.2CDKN2A, MYC, CCND1
14
Hide members
9.2CDKN2A, MYC, CCND1
159.2CCND1, MTOR, MYC
16
Development Prolactin receptor signaling
Hide members
9.2CCND1, MTOR, MYC
179.2CCND1, MTOR, MYC
189.2CCND1, MTOR, MYC
19
Hide members
9.2MYC, MTOR, CCND1
20
Hide members
9.2MYC, MTOR, CCND1
21
Hide members
9.2MYC, MTOR, CCND1
22
Hide members
9.2MYC, MTOR, CCND1
239.1ABCB1, MYC, CCND1
248.7CCND1, MTOR, MYC, CDKN2A
25
Hide members
8.4CCND1, MYC, CDKN2A, BCL6
26
Hide members
8.3MTOR, IGH, PTPRC, BCL6
278.0BCL6, NOTCH1, MYC, MTOR, CCND1
287.7CCND1, MTOR, MYC, CDKN2A, ABCB1, NOTCH1

Compounds for genes affiliated with Plasmablastic Lymphoma

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1serine4510.4CCND1
2depsipeptide4510.0CCND1, CDKN2A
3tachyplesin i4510.0CDKN2A, MYC
4pga2459.9CCND1, MYC
5tamoxifen45 50 29 1112.9CCND1, MTOR
6hematoxylin459.8CDKN2A, MS4A1, PTPRC
7farnesylthiosalicylic acid45 2910.7CCND1, MTOR
8cyclopamine45 6010.7MYC, CCND1
9trimetrexate45 1110.7CDKN2A, ABCB1
10roscovitine459.6CCND1, MYC, CDKN2A
11temsirolimus45 1110.6MTOR, ABCB1
12everolimus50 45 1111.6CCND1, MTOR, MYC
13acnu459.6CDKN2A, ABCB1
14melphalan45 1110.4CCND1, MYC, ABCB1
15sirolimus50 1110.4MTOR, ABCB1
16daunorubicin45 50 1111.3ABCB1, CDKN2A, MYC
17erlotinib45 50 1111.3CCND1, MTOR, ABCB1
18sorafenib45 50 1111.3ABCB1, MTOR, CCND1
19n acetylcysteine459.3PTPRC, CDKN2A, MYC, CCND1
20agarose459.2IGH, MYC, CDKN2A, PTPRC
21gefitinib45 50 1111.2ABCB1, MTOR, CCND1
22droloxifene459.2ABCB1, MYC
23paraffin459.1MYC, MS4A1, PTPRC, BCL6
24gemcitabine45 50 1111.1ABCB1, MYC, CCND1
25rapamycin459.1NOTCH1, MYC, MTOR, CCND1
26adriamycin459.0CCND1, MYC, CDKN2A, ABCB1
27rituximab45 50 1111.0MTOR, CD38, MS4A1, BCL6
28tacrolimus45 50 1110.9ABCB1, MYC, MTOR, CCND1
29ly294002458.9NOTCH1, MYC, MTOR, CCND1
30glycogen45 249.9PTPRC, NOTCH1, MYC, MTOR, CCND1
31docetaxel45 50 60 1111.9MTOR, MYC, CDKN2A, ABCB1
32paclitaxel45 50 1110.9CCND1, MYC, CDKN2A, ABCB1
33arsenite45 249.9ABCB1, CDKN2A, MTOR, CCND1
3412-o-tetradecanoylphorbol 13-acetate458.8BCL6, PTPRC, MYC, MTOR
35cyclophosphamide45 50 1110.6BCL6, MS4A1, ABCB1, MTOR
36actinomycin d458.6MYC, CDKN2A, CD38, ABCB1
37phosphatidylinositol458.6CCND1, MTOR, MYC, CD38, NOTCH1, PTPRC
38lipid458.6MTOR, CDKN2A, CD38, NOTCH1, MS4A1, PTPRC
39vegf458.5CCND1, MTOR, MYC, CDKN2A, NOTCH1
40testosterone45 60 11 2411.5CCND1, MTOR, CDKN2A, ABCB1, PTPRC
41cisplatin45 50 60 1111.5CCND1, MTOR, MYC, CDKN2A, ABCB1
42threonine458.5CCND1, MTOR, MYC, CDKN2A, NOTCH1, PTPRC
43vincristine45 50 1110.2CCND1, MYC, CDKN2A, ABCB1, BCL6
44imatinib45 50 1110.2BCL6, ABCB1, MYC, MTOR, CCND1
45dexamethasone45 50 29 1111.0MTOR, MYC, CDKN2A, CD38, ABCB1, NOTCH1
46genistein45 29 60 2 11 2412.9CCND1, MTOR, MYC, CDKN2A, ABCB1, NOTCH1
47tyrosine457.8CCND1, MTOR, MYC, CD38, NOTCH1, PTPRC
48retinoic acid45 248.7CCND1, MTOR, MYC, CDKN2A, CD38, NOTCH1
49estrogen457.7CCND1, MTOR, MYC, CDKN2A, NOTCH1, PTPRC
50doxorubicin45 50 119.4BCL6, CCND1, MTOR, MYC, CDKN2A, ABCB1

GO Terms for genes affiliated with Plasmablastic Lymphoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:0508539.9PTPRC, CD38
2somatic stem cell divisionGO:0481039.7CDKN2A, NOTCH1
3positive regulation of B cell proliferationGO:0308909.2BCL6, PTPRC, CD38
4negative regulation of cell-matrix adhesionGO:0019539.2BCL6, CDKN2A
5response to drugGO:0424938.9ABCB1, CD38, MYC, CCND1
6positive regulation of transcription, DNA-dependentGO:0458938.9IRF4, MYC, CDKN2A, CD38, NOTCH1
7response to DNA damage stimulusGO:0069748.6BCL6, MYC, CCND1
8negative regulation of transcription, DNA-dependentGO:0458928.5CDKN2A, CD38, NOTCH1, BCL6

Molecular functions related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin DNA bindingGO:0314909.3BCL6, NOTCH1
2protein bindingGO:0055156.0BCL6, CCND1, IRF4, MTOR, MYC, CDKN2A

Products for genes affiliated with Plasmablastic Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Plasmablastic Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet