PBL
MCID: PLS025
MIFTS: 53

Plasmablastic Lymphoma (PBL) malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Plasmablastic Lymphoma

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34MalaCards
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MalaCards: Plasmablastic Lymphoma, also known as immunoblastic large-cell lymphoma, is related to plasmacytoma and chronic lymphocytic leukemia. An important gene associated with Plasmablastic Lymphoma is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Interferon type I and Pre-NOTCH Expression and Processing. The compounds temsirolimus and tachyplesin i have been mentioned in the context of this disorder. Affiliated tissues include b cells, spinal cord and liver, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Plasmablastic Lymphoma

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44NIH Rare Diseases, 50Orphanet, 63UMLS, 64UMLS via Orphanet, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Aliases & Descriptions:

plasmablastic lymphoma 44 50
immunoblastic large-cell lymphoma 63
pbl 50


External Ids:

UMLS via Orphanet64 C3472614
SNOMED-CT via Orphanet60 450909005
ICD10 via Orphanet27 C83.3

Related Diseases for Plasmablastic Lymphoma

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18GeneCards, 19GeneDecks
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Diseases related to Plasmablastic Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1plasmacytoma30.3BCL6, PTPRC, IGH, MYC, IRF4
2chronic lymphocytic leukemia30.3PTPRC, IGH, ABCB1, MS4A1, CCND1, BCL6
3b-cell lymphomas30.2IGH, PTPRC, MYC, IRF4, MS4A1, CCND1
4mantle cell lymphoma30.2BCL6, CCND1
5hodgkin's lymphoma30.2BCL6, MS4A1, IGH, PTPRC, IRF4
6sarcoma30.1MTOR, PTPRC, ABCB1
7myeloma30.1MTOR, CCND1, IRF4, MYC, PTPRC, IGH
8leukemia30.0ABCB1, CD38, CDKN2A, NOTCH1, BCL6, CCND1
9follicular lymphoma30.0CCND1, PTPRC, IGH, MYC, IRF4, MS4A1
10chronic myeloid leukemia29.9ABCB1, PTPRC, MYC, IRF4
11myeloid leukemia29.9PTPRC, MYC, ABCB1, CD38
12t-cell leukemia29.9PTPRC, IGH, MYC, IRF4, NOTCH1
13lung cancer29.7CDKN2A, ABCB1, CCND1, MTOR, NOTCH1, MYC
14crohn's disease10.4
15diffuse large b-cell lymphoma10.3
16gingivitis10.3
17hiv-110.3
18hepatitis10.3
19hiv/aids10.3
20testicular lymphoma10.1BCL6
21hepatitis c10.1
22richter's syndrome10.1
23acquired immunodeficiency syndrome10.1
24hepatitis b10.1
25kaposi's sarcoma10.1
26epidermodysplasia verruciformis10.1
27orbital cellulitis10.1
28cellulitis10.1
29cervicitis10.1
30esophagitis10.1
31peritonitis10.1
32rectal disease10.1
33castleman's disease10.1
34essential thrombocythemia10.1
35primary effusion lymphoma10.1
36hepatitis c virus10.1
37hepatitis b virus infection10.1
38gastric lymphoma10.1IGH, BCL6
39lymphosarcoma10.1BCL6, IGH
40lymphoma aidsrelated10.1BCL6, MYC
41angiomyolipoma10.1PTPRC, MTOR
42reticulosarcoma10.1BCL6, IGH, PTPRC
43peripheral t-cell lymphoma10.0BCL6, PTPRC, MS4A1
44anaplastic large cell lymphoma10.0BCL6, PTPRC
45immunodeficiency with hyper igm type 210.0BCL6, PTPRC, CD38
46burkitt's lymphoma10.0BCL6, CCND1
47b-cell chronic lymphocytic leukemia10.0CCND1, MS4A1, IGH
48malignant peripheral nerve sheath tumor10.0CDKN2A, ABCB1
49polycystic kidney disease, autosomal dominant10.0MYC, MTOR
50lymphoblastic lymphoma10.0MS4A1, BCL6, PTPRC, NOTCH1

Graphical network of the top 20 diseases related to Plasmablastic Lymphoma:



Diseases related to plasmablastic lymphoma

Symptoms for Plasmablastic Lymphoma

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Drugs & Therapeutics for Plasmablastic Lymphoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Plasmablastic Lymphoma

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Anatomical Context for Plasmablastic Lymphoma

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34MalaCards
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MalaCards organs/tissues related to Plasmablastic Lymphoma:

34
B cells, Spinal cord, Liver, Testes, Skin, Lung, Small intestine, Lymph node, Bone, Colon, Breast, Uterus, Testis, Cervix, Bone marrow

Animal Models for Plasmablastic Lymphoma or affiliated genes

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38MGI
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Publications for Plasmablastic Lymphoma

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53PubMed
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Articles related to Plasmablastic Lymphoma:

(show top 50)    (show all 183)
idTitleAuthorsYear
1
Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation. (24349055)
2013
2
Brentuximab vedotin demonstrates activity in a patient with plasmablastic lymphoma arising from a background of chronic lymphocytic leukemia. (23509308)
2013
3
An uncommon case of epidural plasmablastic lymphoma presents as spinal cord compression. (23993656)
2013
4
Primary cutaneous plasmablastic lymphoma in an immunocompetent patient. (24124865)
2013
5
Bortezomib in plasmablastic lymphoma: a case report and review of the literature. (23689224)
2013
6
Plasmablastic lymphoma of the maxillary sinus in an HIV-negative patient: a case report and literature review. (23667804)
2013
7
Multifocal cranial plasmablastic lymphoma as a rare manifestation of posttransplant lymphoproliferative disorder. (22976265)
2012
8
Quantification of plasma Epstein-Barr virus DNA for assessing treatment response in a patient with plasmablastic lymphoma. (21881823)
2012
9
Lack and/or aberrant localization of major histocompatibility class II (MHCII) protein in plasmablastic lymphoma. (22689685)
2012
10
Plasmablastic Lymphoma presenting as small intestinal polyposis: A case-report. (23285420)
2012
11
Unusual presentation of gastric plasmablastic lymphoma in HIV-negative patient. (21476144)
2012
12
Plasmablastic lymphoma of the retroperitoneum in an HIV- and HCV-positive patient: hard to diagnose and harder to treat. (22562157)
2012
13
Oral and extraoral plasmablastic lymphoma: similarities and differences in clinicopathologic characteristics. (21571968)
2011
14
Oral plasmablastic lymphoma: a case report. (21884151)
2011
15
Uniform expression of Notch1, suppressor of B-cell-specific gene expression, in plasmablastic lymphoma. (21631271)
2011
16
Surgical resection of small bowel plasmablastic lymphoma for chronic bleeding. (21944334)
2011
17
Plasmablastic lymphoma of the right testis. (21073544)
2011
18
Interesting image. Assessment of plasmablastic lymphoma by F-18 FDG PET/CT: case report. (20940549)
2010
19
Plasmablastic lymphoma with MYC translocation: evidence for a common pathway in the generation of plasmablastic features. (20348882)
2010
20
Plasmablastic lymphoma in a human immunodeficiency virus negative patient. (20551562)
2010
21
Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement. (21088162)
2010
22
Diagnosis and treatment of myelo-osteolytic plasmablastic lymphoma of the femur in a domestic ferret. (20707751)
2010
23
Clinical and pathological differences between human immunodeficiency virus-positive and human immunodeficiency virus-negative patients with plasmablastic lymphoma. (20919850)
2010
24
Plasmablastic lymphoma in the anal canal. (19809569)
2009
25
Plasmablastic lymphoma in an immunocompetent patient. (19581534)
2009
26
Multifocal cutaneous and systemic plasmablastic lymphoma in an infant with combined living donor small bowel and liver transplant. (19067927)
2009
27
Plasmablastic lymphoma of the retroperitoneum in an HIV-negative patient. (20021612)
2009
28
Cutaneous nodules as diagnostic key of an extraoral plasmablastic lymphoma in an human immunodeficiency virus-infected patient. (18028356)
2008
29
Plasmablastic lymphoma involving breast: a case diagnosed by fine-needle aspiration and core needle biopsy. (18335555)
2008
30
Sonographic appearance of plasmablastic lymphoma of the testes. (18499857)
2008
31
Plasmablastic lymphoma mimicking orbital cellulitis. (18597126)
2008
32
EBV detection in HIV-related oral plasmablastic lymphoma. (17944673)
2007
33
Images in HIV/AIDS. Oral plasmablastic lymphoma. (17902226)
2007
34
Extranodal plasmablastic lymphoma arising in mantle cell lymphoma. (17903200)
2007
35
Plasmablastic lymphoma of head and neck: report of two new cases and correlation with c-myc and IgVH gene mutation status. (20614267)
2007
36
Editorial comment: plasmablastic lymphoma--a diagnostic and therapeutic puzzle. (17902227)
2007
37
Plasmablastic lymphoma of visceral cranium, cervix and thorax in an HIV-negative woman. (17361427)
2007
38
Extra-oral plasmablastic lymphoma: report of a case and review of literature. (16938530)
2006
39
Incidental oral plasmablastic lymphoma with aberrant expression of CD4 in an elderly HIV-negative patient: how a gingival polyp can cause confusion. (15720425)
2005
40
Cytologic features of plasmablastic lymphoma. (15803491)
2005
41
Improved outcome of human immunodeficiency virus-associated plasmablastic lymphoma of the oral cavity in the era of highly active antiretroviral therapy: a report of two cases. (15223650)
2004
42
Cutaneous plasmablastic lymphoma in an HIV-positive male: an unrecognized cutaneous manifestation. (15118393)
2004
43
Plasmablastic lymphoma of the cervical lymph nodes in a human immunodeficiency virus-negative patient: a case report and review of the literature. (15086296)
2004
44
Plasmablastic lymphoma presenting in a human immunodeficiency virus-negative patient: a case report. (12783213)
2003
45
Plasmablastic lymphoma of the oral cavity and jaws. (12351965)
2002
46
Molecular histogenesis of plasmablastic lymphoma of the oral cavity. (12437635)
2002
47
Plasmablastic lymphoma of the lung: report of a unique case and review of the literature. (11175653)
2001
48
HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. (10666218)
2000
49
Plasmablastic lymphoma of the stomach. A case report. (9542326)
1998
50
Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. (9028965)
1997

Variations for Plasmablastic Lymphoma

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Expression for genes affiliated with Plasmablastic Lymphoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plasmablastic Lymphoma

Search GEO for disease gene expression data for Plasmablastic Lymphoma.

Pathways for genes affiliated with Plasmablastic Lymphoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 31KEGG, 61Thomson Reuters, 52PharmGKB, 55R&D Systems, 13EMD Millipore
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Pathways related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MTOR, PTPRC
2
Show member pathways
9.6NOTCH1, CCND1
39.5MTOR, MYC
49.5MYC, MTOR
59.4MYC, CDKN2A
6
Show member pathways
9.4MYC, CDKN2A
79.3MYC, CCND1
89.3CCND1, MYC
99.3CCND1, MYC
109.3CCND1, MYC
119.3BCL6, MTOR, IRF4
12
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.2CDKN2A, IRF4, MYC
13
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.0MTOR, CCND1, MYC
14
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.0MTOR, CCND1, MYC
15
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.0MTOR, CCND1, MYC
16
Show member pathways
Signal transduction PTEN pathway61
9.0MTOR, CCND1, MYC
179.0MTOR, CCND1, MYC
189.0MYC, CCND1, MTOR
19
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.0MYC, CCND1, MTOR
209.0MYC, CCND1, MTOR
21
Show member pathways
Notch signaling pathway39
9.0NOTCH1, CCND1, MYC
229.0MYC, CCND1, NOTCH1
23
Show member pathways
9.0MYC, CCND1, NOTCH1
248.9CDKN2A, CCND1, MYC
25
Show member pathways
8.9CDKN2A, CCND1, MYC
268.9MYC, CCND1, CDKN2A
27
Show member pathways
Cell cycle39
8.9MYC, CCND1, CDKN2A
28
Show member pathways
8.9MYC, CCND1, CDKN2A
29
Show member pathways
DNA damage response39
8.9MYC, CCND1, CDKN2A
308.9CCND1, MYC, ABCB1
31
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
8.8IGH, PTPRC, BCL6
328.6NOTCH1, MTOR, CCND1, MYC
33
Show member pathways
Signaling Pathways in Glioblastoma39
8.6CDKN2A, MTOR, CCND1, MYC
348.6CDKN2A, MTOR, CCND1, MYC
35
Show member pathways
8.5CDKN2A, NOTCH1, CCND1, MYC
36
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
8.4MYC, CCND1, BCL6, CDKN2A
37
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
8.2IGH, MYC, CCND1, MTOR
388.1NOTCH1, BCL6, MTOR, CCND1, MYC
397.7ABCB1, MYC, CCND1, MTOR, NOTCH1, CDKN2A

Compounds for genes affiliated with Plasmablastic Lymphoma

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46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1temsirolimus46 1210.9ABCB1, MTOR
2tachyplesin i469.8CDKN2A, MYC
3hematoxylin469.8MS4A1, CDKN2A, PTPRC
4trimetrexate46 1210.8ABCB1, CDKN2A
5farnesylthiosalicylic acid30 4610.7CCND1, MTOR
6acnu469.6CDKN2A, ABCB1
7erlotinib46 52 1211.5ABCB1, CCND1, MTOR
8sorafenib46 52 1211.5CCND1, MTOR, ABCB1
9rituximab46 52 1211.5CD38, BCL6, MS4A1, MTOR
10everolimus46 52 1211.4MTOR, CCND1, MYC
11gefitinib46 52 1211.4MTOR, CCND1, ABCB1
12roscovitine469.3CDKN2A, CCND1, MYC
13cyclophosphamide46 52 1211.3ABCB1, MS4A1, MTOR, BCL6
14daunorubicin46 52 1211.3MYC, CDKN2A, ABCB1
15pga2469.2MYC, CCND1
16melphalan46 52 1211.2ABCB1, CCND1, MYC
17docetaxel46 52 62 1212.0ABCB1, CDKN2A, MTOR, MYC
1812-o-tetradecanoylphorbol 13-acetate469.0PTPRC, MTOR, MYC, BCL6
19gemcitabine46 52 1211.0ABCB1, CCND1, MYC
20n acetylcysteine468.9MYC, CDKN2A, CCND1, PTPRC
21tacrolimus46 52 1210.9MTOR, MYC, ABCB1, CCND1
22depsipeptide468.9ABCB1, MYC, CCND1, CDKN2A
23actinomycin d468.9CD38, CDKN2A, MYC, ABCB1
24adriamycin468.9ABCB1, CCND1, CDKN2A, MYC
25rapamycin468.9CCND1, MTOR, NOTCH1, MYC
26ly294002468.9MTOR, MYC, CCND1, NOTCH1
27tamoxifen46 52 30 1211.9CCND1, MTOR, MYC, ABCB1
28lipid468.8MTOR, NOTCH1, MS4A1, CD38, PTPRC, CDKN2A
29testosterone46 62 25 1211.8ABCB1, MTOR, CDKN2A, CCND1, PTPRC
30lovastatin46 52 62 30 1212.8CCND1, CDKN2A, ABCB1
31paclitaxel46 52 1210.8ABCB1, CDKN2A, CCND1, MYC
32cyclosporin a46 30 6210.7ABCB1, PTPRC, MYC, MTOR
33glycogen46 259.7MYC, CCND1, MTOR, NOTCH1, PTPRC
34agarose468.7MYC, PTPRC, IGH, CDKN2A
35arsenite46 259.6MYC, CCND1, MTOR, CDKN2A, ABCB1
36cisplatin46 52 62 1211.5CCND1, MYC, CDKN2A, ABCB1, MTOR
37vegf468.5NOTCH1, CCND1, MYC, CDKN2A, MTOR
38cycloheximide468.5MYC, CCND1, BCL6, CDKN2A, PTPRC
39imatinib46 52 1210.4BCL6, MTOR, CCND1, MYC, ABCB1
40phosphatidylinositol468.4PTPRC, MYC, MTOR, CD38, NOTCH1, CCND1
41vincristine46 52 1210.4ABCB1, MYC, CDKN2A, BCL6, CCND1
42threonine468.3PTPRC, CCND1, MYC, CDKN2A, MTOR, NOTCH1
43paraffin468.3MS4A1, CCND1, BCL6, PTPRC, MYC, CDKN2A
44dexamethasone46 52 30 1211.1MTOR, CD38, CDKN2A, NOTCH1, MYC, ABCB1
45genistein46 30 62 3 25 1212.9CCND1, PTPRC, MYC, MTOR, NOTCH1, CDKN2A
46tyrosine467.9BCL6, MTOR, CD38, CCND1, PTPRC, MYC
47retinoic acid46 258.8MYC, CCND1, NOTCH1, MTOR, BCL6, CD38
48estrogen467.8CCND1, NOTCH1, MTOR, MYC, PTPRC, CDKN2A
49serine467.8CCND1, PTPRC, MYC, MTOR, CDKN2A, NOTCH1
50doxorubicin46 52 129.7CCND1, ABCB1, CDKN2A, MYC, MTOR, BCL6

GO Terms for genes affiliated with Plasmablastic Lymphoma

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17Gene Ontology
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Cellular components related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:0160208.9CD38, MTOR, CCND1, ABCB1

Biological processes related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1somatic stem cell divisionGO:0481039.9CDKN2A, NOTCH1
2B cell receptor signaling pathwayGO:0508539.9PTPRC, CD38
3B cell proliferationGO:0421009.8PTPRC, MS4A1
4negative regulation of cell-matrix adhesionGO:0019539.7BCL6, CDKN2A
5positive regulation of B cell proliferationGO:0308909.6CD38, BCL6, PTPRC
6Notch signaling pathwayGO:0072199.2MYC, CCND1, NOTCH1
7negative regulation of transcription, DNA-templatedGO:0458929.0CD38, CDKN2A, NOTCH1, BCL6
8cellular response to DNA damage stimulusGO:0069748.9BCL6, CCND1, MYC
9response to drugGO:0424938.8ABCB1, MYC, CCND1, CD38
10positive regulation of transcription, DNA-templatedGO:0458938.7MYC, IRF4, NOTCH1, CDKN2A, CD38
11negative regulation of transcription from RNA polymerase II promoterGO:0001228.5MYC, CCND1, BCL6, NOTCH1
12positive regulation of transcription from RNA polymerase II promoterGO:0459448.5MYC, IRF4, NOTCH1, CDKN2A
13transcription, DNA-templatedGO:0063518.1CDKN2A, BCL6, CCND1, IRF4, MYC

Molecular functions related to Plasmablastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin DNA bindingGO:0314909.3NOTCH1, BCL6
2protein kinase bindingGO:0199019.2CDKN2A, CCND1, PTPRC
3transcription factor bindingGO:0081348.6CDKN2A, CCND1, IRF4, MYC
4protein bindingGO:0055156.5ABCB1, PTPRC, MYC, IRF4, CCND1, MTOR

Products for genes affiliated with Plasmablastic Lymphoma

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  • Antibodies
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Sources for Plasmablastic Lymphoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet