MCID: PLS011
MIFTS: 56

Plasmacytoma malady

Cancer diseases, Neuronal diseases, Blood diseases, Rare diseases categories

Summaries for Plasmacytoma

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Wikipedia:64 Plasmacytoma refers to a malignant plasma cell tumor growing within soft tissue or within the axial... more...

MalaCards based summary: Plasmacytoma, also known as solitary plasmacytoma, is related to multiple myeloma and myeloma. An important gene associated with Plasmacytoma is B2M (beta-2-microglobulin), and among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Cytokine production by Th17 cells in CF. The compounds pamidronate and pmma have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and thyroid, and related mouse phenotypes are tumorigenesis and normal.

Aliases & Classifications for Plasmacytoma

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Sources:
9Disease Ontology, 11DISEASES, 44Novoseek, 48Orphanet, 61UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet, 26ICD10
See all sources

Plasmacytoma, Aliases & Descriptions:

Name: Plasmacytoma 9 11 44 48 61
Solitary Plasmacytoma 9 48 61
Solitary Myeloma 9 61
 
Myeloma - Solitary 9
Myeloma, Solitary 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

48
plasmacytoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly


External Ids:

Disease Ontology9 DOID:3721
NCIt39 C9349, C6932
MeSH34 D010954
MESH via Orphanet35 D010954
ICD10 via Orphanet27 C90.2
UMLS via Orphanet62 C0032131
ICD1026 C90.3

Related Diseases for Plasmacytoma

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Diseases related to Plasmacytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1multiple myeloma31.3IL6, IRF4, B2M
2myeloma30.5B2M, IRF4, PRDM1, IL6, CD79B, CD27
3macroglobulinemia30.4B2M
4peritonitis30.4IL6, B2M
5b-cell lymphomas29.9AICDA, IRF4, PRDM1, CD79B
6burkitt's lymphoma29.9CD27, AICDA
7hodgkin's lymphoma29.3AICDA, IRF4, PRDM1, STMN1
8leukemia28.8AICDA, B2M, IRF4, PRDM1, STMN1, IL6
9extramedullary plasmacytoma11.2
10thyroiditis10.6
11anaplastic plasmacytoma10.5
12cervicitis10.4
13solitary osseous plasmacytoma10.4
14amyloidosis10.4
15tonsillitis10.3
16mediastinitis10.3
17pancreatitis10.3
18acquired immunodeficiency syndrome10.3IL6, B2M
19viral meningitis10.3B2M, IL6
20lymphopenia10.2IL6, B2M
21poems syndrome10.2
22solitary plasmacytoma of chest wall10.2
23meningioma10.2
24extramedullary soft tissue plasmacytoma10.2
25synovitis10.2B2M, IL6
26hypersensitivity reaction type ii disease10.2IL6, B2M
27sinusitis10.2
28obstructive jaundice10.2
29plasma cell neoplasm10.2
30polyneuropathy10.2
31sarcoma10.2
32castleman's disease10.2
33plasma cell leukemia10.2
34marginal zone b-cell lymphoma10.1
35intussusception10.1
36duodenitis10.1
37adenocarcinoma10.1
38back pain10.1
39primary plasmacytoma of the bone10.1
40frontal sinusitis10.1
41chronic myeloid leukemia10.0
42hemangioma10.0
43malt lymphoma10.0
44neuronitis10.0
45nasopharyngitis10.0
46gastroduodenitis10.0
47choroiditis10.0
48cerebritis10.0
49adenoma10.0
50dacryocystitis10.0

Graphical network of the top 20 diseases related to Plasmacytoma:



Diseases related to plasmacytoma

Symptoms for Plasmacytoma

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Drugs & Therapeutics for Plasmacytoma

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Drug clinical trials:

Search ClinicalTrials for Plasmacytoma

Search NIH Clinical Center for Plasmacytoma

Genetic Tests for Plasmacytoma

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Anatomical Context for Plasmacytoma

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MalaCards organs/tissues related to Plasmacytoma:

32
Bone, Bone marrow, Thyroid, Breast, Colon, Pancreas, Skin, Lymph node, Lung, B cells, Liver, Tonsil, Kidney, Tongue, Heart, Small intestine, Testis, Brain, Salivary gland, Skeletal muscle, Adrenal gland, Ovary, Cervix, T cells, Trachea, Pituitary, Spinal cord, Myeloid, Endothelial, Prostate, Nk cells

Animal Models for Plasmacytoma or affiliated genes

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MGI Mouse Phenotypes related to Plasmacytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3B2M, IRF4, IL6, AICDA
2MP:00028738.1CD79B, STMN1, PRDM1, AICDA
3MP:00053847.7IL6, PRDM1, B2M, AICDA, CD27
4MP:00053977.1CD27, CD79B, IL6, PRDM1, IRF4, B2M
5MP:00053877.0AICDA, B2M, PRDM1, IL6, CD79B, CD27

Publications for Plasmacytoma

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Articles related to Plasmacytoma:

(show top 50)    (show all 882)
idTitleAuthorsYear
1
Gradenigo's syndrome as first presentation of solitary osseous plasmacytoma of the petrous apex. (24979569)
2014
2
Extramedullary plasmacytoma in the lung of a Doberman pinscher dog. (24381343)
2014
3
Solitary plasmacytoma of the mandible - a rare entity. (24155610)
2013
4
Multiple myeloma presenting as plasmacytoma of the jaws showing prominent bone formation during chemotherapy. (23520399)
2013
5
A variant of AESOP syndrome (adenopathy and extensive skin patch overlying a plasmacytoma)--reply. (24048432)
2013
6
Primary plasmacytoma of the kidney. (23936722)
2013
7
Plasmacytoma associated with canaliculitis. (21743365)
2012
8
Rib plasmacytoma and IgA multiple myeloma with hyperviscosity syndrome. (22827791)
2012
9
The role of helical tomotherapy in the treatment of bone plasmacytoma. (21705210)
2012
10
Plasmacytoma-like posttransplant lymphoproliferative disorder following orthotopic liver transplantation: a case report. (21911168)
2011
11
Anal canal plasmacytoma-An uncommon presentation site. (24376953)
2010
12
Images in clinical medicine. Plasmacytoma of the skull. (21105787)
2010
13
A rare case of primary gastric plasmacytoma: an unforeseen surprise. (21358099)
2010
14
Dacryocystitis provoked by recurrence of extramedullary plasmacytoma of the orbit: a case report. (20437877)
2010
15
Skeletal Plasmacytoma: progression of disease and impact of local treatment; an analysis of SEER database. (19778427)
2009
16
Radiotherapy for extramedullary plasmacytoma of the head and neck. (18707826)
2009
17
Port site and local recurrence of incidental solitary renal plasmacytoma after retroperitoneoscopic radical nephrectomy. (18336883)
2009
18
Synchronous oral squamous cell carcinoma and extramedullary plasmacytoma of the tonsil. (19570691)
2009
19
Successful treatment of extramedullary gastric plasmacytoma with the combination of bortezomib and dexamethasone: first reported case. (17560647)
2008
20
Incidental detection of concurrent extramedullary plasmacytoma and amyloidoma of the nasopharynx on [18F]fluorodeoxyglucose positron emission tomography/computed tomography. (19001338)
2008
21
Extramedullary plasmacytoma in the maxillary sinus. (19037537)
2008
22
Laryngeal plasmacytoma presenting as amyloid tumour: a case report. (17431662)
2007
23
Amyloid-depositing plasmacytoma of cervical spine masquerades as a granulomatous inflammatory reaction. (17206313)
2007
24
Cutaneous plasmacytoma in three golden hamsters (Mesocrietus auratus). (16466459)
2006
25
Multifocal extramedullary plasmacytoma with paraproteinemia, pleural involvement and retroperitoneal lymphadenopathy: an uncommon pattern of relapse of solitary osseous plasmacytoma. (16496148)
2006
26
Extramedullary plasmacytoma of the salivary gland in two Syrian hamsters (Mesocricetus auratus). (16301579)
2005
27
Uterine extramedullary plasmacytoma in a dog. (15200080)
2004
28
Insights into extramedullary tumour cell growth revealed by expression profiling of human plasmacytomas and multiple myeloma. (12930383)
2003
29
Unilateral exophthalmos caused by an extramedullary plasmacytoma: a case report. (23365508)
2003
30
Solitary extramedullary plasmacytoma of the premaxilla. (12780455)
2003
31
A case of retroperitoneal extramedullary plasmacytoma with multiple metastases. (11368939)
2000
32
Murine plasmacytomas, carrier of the t(12;15) chromosomal translocation, develop from immature/mature B cells not from differentiated plasma cells. (10223178)
1999
33
Primary gastric plasmacytoma: a rare cause of hypertrophic gastritis in an adolescent. (10512402)
1999
34
Extramedullary plasmacytoma of the head and neck associated with the human immunodeficiency virus. (9473836)
1998
35
Cleaved variant of plasmacytoma with myelomonocytic differentiation--immunohistochemical and ultrastructural studies. (9364303)
1997
36
Fine-needle aspiration of pancreatic extramedullary plasmacytoma: possible confusion with islet cell tumor. (7924813)
1994
37
Extramedullary plasmacytoma of the heart presenting as cardiac emergency. Review of literature. (8092116)
1994
38
Extramedullary plasmacytoma of the head and neck. (7850655)
1994
39
Primary cutaneous extramedullary plasmacytoma secreting lambda IgG. (8403475)
1993
40
A rare case of extramedullary plasmacytoma in the mediastinum. (1300172)
1992
41
Solitary conjunctival extramedullary plasmacytoma. (2350120)
1990
42
Extramedullary plasmacytoma of the testicle. Sonographic appearance and ultrasonically guided biopsy. (2198076)
1990
43
Anaplastic solitary extramedullary plasmacytoma of the cecum. Report of a case confirmed by immunoperoxidase staining. (3315510)
1987
44
Extramedullary plasmacytoma of the lung. (4005784)
1985
45
Extramedullary plasmacytoma of the bladder: a case report and review of literature. (7083118)
1982
46
Extramedullary plasmacytoma of the head and neck. (6792654)
1981
47
Extramedullary plasmacytoma of the parotid gland. (7359969)
1980
48
Mediastinal extramedullary plasmacytoma. (7375991)
1980
49
Extramedullary plasmacytoma of the gastrointestinal tract in a renal transplant recipient. (380262)
1979
50
Extramedullary plasmacytoma of the head and neck. (5659409)
1968

Variations for Plasmacytoma

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Expression for genes affiliated with Plasmacytoma

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Expression patterns in normal tissues for genes affiliated with Plasmacytoma

Search GEO for disease gene expression data for Plasmacytoma.

Pathways for genes affiliated with Plasmacytoma

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Pathways related to Plasmacytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6IL6, PRDM1
2
Show member pathways
9.6IL6, IRF4
3
Show member pathways
9.2IRF4, IL6, B2M
4
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.2CD79B, IRF4, IL6
59.1AICDA, IRF4
6
Show member pathways
9.1IL6, CD79B, STMN1
7
Show member pathways
8.9AICDA, B2M, IL6
88.8PRDM1, B2M, AICDA

Compounds for genes affiliated with Plasmacytoma

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Compounds related to Plasmacytoma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1pamidronate44 50 1212.1B2M, IL6
2pmma4410.0B2M, IL6
32,5-oligoadenylate4410.0IL6, B2M
4neopterin449.9B2M, IL6
5rituximab44 50 1211.8B2M, IL6
6okt3449.7STMN1, IL6
7pge1449.7IL6, B2M
8dcmp44 2510.6AICDA, B2M
9ivig449.5IL6, AICDA
10thalidomide44 50 60 1212.5B2M, IL6
11cyclosporin a44 29 6011.4IL6, STMN1, B2M
12cytidine44 25 1211.4PRDM1, AICDA
13thymidine44 2510.3B2M, STMN1, IL6
14creatinine449.3IL6, B2M, STMN1
15cycloheximide448.9IL6, AICDA, B2M
16serine448.6B2M, STMN1, CD79B, CD27
17estrogen448.6IL6, STMN1, B2M, AICDA

GO Terms for genes affiliated with Plasmacytoma

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Cellular components related to Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CD27, CD79B, IL6, B2M

Biological processes related to Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T-helper 17 cell lineage commitmentGO:0725409.7IRF4, IL6
2interferon-gamma-mediated signaling pathwayGO:0603339.6IRF4, B2M
3defense response to protozoanGO:0428329.6IL6, IRF4
4positive regulation of B cell differentiationGO:0455799.6PRDM1, CD27
5negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.3CD27, IL6
6cytokine-mediated signaling pathwayGO:0192219.1IL6, B2M, IRF4

Molecular functions related to Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.6CD27, CD79B
2protein bindingGO:0055157.1CD27, IL6, PRDM1, IRF4, B2M, AICDA

Products for genes affiliated with Plasmacytoma

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Sources for Plasmacytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet