MCID: PLS011
MIFTS: 57

Plasmacytoma malady

Cancer diseases, Neuronal diseases, Blood diseases, Rare diseases categories

Summaries for Plasmacytoma

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Plasmacytoma refers to a malignant plasma cell tumor growing within soft tissue or within the axial... more...

MalaCards: Plasmacytoma, also known as solitary plasmacytoma, is related to multiple myeloma and myeloma. An important gene associated with Plasmacytoma is B2M (beta-2-microglobulin), and among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Cytokine production by Th17 cells in CF. The compounds pamidronate and pmma have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and thyroid, and related mouse phenotypes are tumorigenesis and normal.

Aliases & Classifications for Plasmacytoma

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

50
plasmacytoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

plasmacytoma 9 11 46 50 63
solitary plasmacytoma 9 50
myeloma - solitary 9
myeloma, solitary 9
solitary myeloma 9


External Ids:

Disease Ontology9 DOID:3721
NCIt41 C9349, C6932
MeSH36 D010954
MESH via Orphanet37 D010954
ICD10 via Orphanet27 C90.2
SNOMED-CT via Orphanet60 10639003, 415112005
UMLS via Orphanet64 C0032131
ICD1026 C90.3

Related Diseases for Plasmacytoma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Plasmacytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1multiple myeloma31.2IRF4, B2M, IL6
2myeloma31.1CD27, B2M, CD79B, IL6, PRDM1, IRF4
3b-cell lymphomas30.2AICDA, PRDM1, IRF4, CD79B
4leukemia30.1CD27, IL6, STMN1, AICDA, B2M, IRF4
5peritonitis30.1B2M, IL6
6burkitt's lymphoma30.0CD27, AICDA
7macroglobulinemia29.9B2M
8hodgkin's lymphoma29.8AICDA, IRF4, PRDM1, STMN1
9hepatocellular carcinoma29.6STMN1, IL6, AICDA
10extramedullary plasmacytoma11.2
11thyroiditis10.5
12anaplastic plasmacytoma10.5
13cervicitis10.4
14amyloidosis10.3
15tonsillitis10.3
16solitary osseous plasmacytoma10.3
17mediastinitis10.3
18pancreatitis10.3
19poems syndrome10.2
20meningioma10.2
21extramedullary soft tissue plasmacytoma10.2
22obstructive jaundice10.2
23plasma cell neoplasm10.2
24polyneuropathy10.2
25sarcoma10.2
26castleman's disease10.2
27plasma cell leukemia10.2
28sinusitis10.2
29intussusception10.1
30duodenitis10.1
31solitary plasmacytoma of chest wall10.1
32marginal zone b-cell lymphoma10.1
33back pain10.1
34primary plasmacytoma of the bone10.1
35acquired immunodeficiency syndrome10.1IL6, B2M
36viral meningitis10.1IL6, B2M
37lymphopenia10.1B2M, IL6
38frontal sinusitis10.1
39synovitis10.0IL6, B2M
40hypersensitivity reaction type ii disease10.0IL6, B2M
41neuronitis10.0
42chronic myeloid leukemia10.0
43nasopharyngitis10.0
44gastroduodenitis10.0
45choroiditis10.0
46cerebritis10.0
47adenocarcinoma10.0
48adenoma10.0
49dacryocystitis10.0
50demyelinating polyneuropathy10.0

Graphical network of the top 20 diseases related to Plasmacytoma:



Diseases related to plasmacytoma

Symptoms for Plasmacytoma

About this section

Drugs & Therapeutics for Plasmacytoma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Plasmacytoma

Drug clinical trials:

Search ClinicalTrials for Plasmacytoma

Search NIH Clinical Center for Plasmacytoma

Search CenterWatch for Plasmacytoma

Genetic Tests for Plasmacytoma

About this section

Anatomical Context for Plasmacytoma

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Plasmacytoma:

34
Bone, Bone marrow, Thyroid, Colon, Breast, Skin, Pancreas, Lung, Lymph node, B cells, Liver, Tonsil, Kidney, Tongue, Heart, Testis, Small intestine, Salivary gland, Brain, T cells, Trachea, Cervix, Ovary, Adrenal gland, Pituitary, Myeloid, Endothelial, Skeletal muscle, Spinal cord, Prostate, Nk cells

Animal Models for Plasmacytoma or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Plasmacytoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3IL6, IRF4, B2M, AICDA
2MP:00028738.1CD79B, STMN1, PRDM1, AICDA
3MP:00053847.7AICDA, B2M, PRDM1, IL6, CD27
4MP:00053977.1CD27, AICDA, B2M, IRF4, PRDM1, IL6
5MP:00053877.0AICDA, B2M, IRF4, PRDM1, IL6, CD79B

Publications for Plasmacytoma

About this section
Sources:
53PubMed
See all sources

Articles related to Plasmacytoma:

(show top 50)    (show all 852)
idTitleAuthorsYear
1
Extramedullary plasmacytoma in the lung of a Doberman pinscher dog. (24381343)
2014
2
Solitary plasmacytoma of the mandible - a rare entity. (24155610)
2013
3
Multiple myeloma presenting as plasmacytoma of the jaws showing prominent bone formation during chemotherapy. (23520399)
2013
4
A variant of AESOP syndrome (adenopathy and extensive skin patch overlying a plasmacytoma)--reply. (24048432)
2013
5
Primary plasmacytoma of the kidney. (23936722)
2013
6
Plasmacytoma associated with canaliculitis. (21743365)
2012
7
Rib plasmacytoma and IgA multiple myeloma with hyperviscosity syndrome. (22827791)
2012
8
The role of helical tomotherapy in the treatment of bone plasmacytoma. (21705210)
2012
9
Plasmacytoma-like posttransplant lymphoproliferative disorder following orthotopic liver transplantation: a case report. (21911168)
2011
10
Anal canal plasmacytoma-An uncommon presentation site. (24376953)
2010
11
Images in clinical medicine. Plasmacytoma of the skull. (21105787)
2010
12
A rare case of primary gastric plasmacytoma: an unforeseen surprise. (21358099)
2010
13
Dacryocystitis provoked by recurrence of extramedullary plasmacytoma of the orbit: a case report. (20437877)
2010
14
Skeletal Plasmacytoma: progression of disease and impact of local treatment; an analysis of SEER database. (19778427)
2009
15
Radiotherapy for extramedullary plasmacytoma of the head and neck. (18707826)
2009
16
Port site and local recurrence of incidental solitary renal plasmacytoma after retroperitoneoscopic radical nephrectomy. (18336883)
2009
17
Synchronous oral squamous cell carcinoma and extramedullary plasmacytoma of the tonsil. (19570691)
2009
18
Successful treatment of extramedullary gastric plasmacytoma with the combination of bortezomib and dexamethasone: first reported case. (17560647)
2008
19
Incidental detection of concurrent extramedullary plasmacytoma and amyloidoma of the nasopharynx on [18F]fluorodeoxyglucose positron emission tomography/computed tomography. (19001338)
2008
20
Extramedullary plasmacytoma in the maxillary sinus. (19037537)
2008
21
Laryngeal plasmacytoma presenting as amyloid tumour: a case report. (17431662)
2007
22
Amyloid-depositing plasmacytoma of cervical spine masquerades as a granulomatous inflammatory reaction. (17206313)
2007
23
Cutaneous plasmacytoma in three golden hamsters (Mesocrietus auratus). (16466459)
2006
24
Multifocal extramedullary plasmacytoma with paraproteinemia, pleural involvement and retroperitoneal lymphadenopathy: an uncommon pattern of relapse of solitary osseous plasmacytoma. (16496148)
2006
25
Extramedullary plasmacytoma of the salivary gland in two Syrian hamsters (Mesocricetus auratus). (16301579)
2005
26
Uterine extramedullary plasmacytoma in a dog. (15200080)
2004
27
Insights into extramedullary tumour cell growth revealed by expression profiling of human plasmacytomas and multiple myeloma. (12930383)
2003
28
Unilateral exophthalmos caused by an extramedullary plasmacytoma: a case report. (23365508)
2003
29
Solitary extramedullary plasmacytoma of the premaxilla. (12780455)
2003
30
A case of retroperitoneal extramedullary plasmacytoma with multiple metastases. (11368939)
2000
31
Murine plasmacytomas, carrier of the t(12;15) chromosomal translocation, develop from immature/mature B cells not from differentiated plasma cells. (10223178)
1999
32
Primary gastric plasmacytoma: a rare cause of hypertrophic gastritis in an adolescent. (10512402)
1999
33
Extramedullary plasmacytoma of the head and neck associated with the human immunodeficiency virus. (9473836)
1998
34
Cleaved variant of plasmacytoma with myelomonocytic differentiation--immunohistochemical and ultrastructural studies. (9364303)
1997
35
Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. (8883660)
1996
36
Fine-needle aspiration of pancreatic extramedullary plasmacytoma: possible confusion with islet cell tumor. (7924813)
1994
37
Extramedullary plasmacytoma of the heart presenting as cardiac emergency. Review of literature. (8092116)
1994
38
Extramedullary plasmacytoma of the head and neck. (7850655)
1994
39
Primary cutaneous extramedullary plasmacytoma secreting lambda IgG. (8403475)
1993
40
A rare case of extramedullary plasmacytoma in the mediastinum. (1300172)
1992
41
Solitary conjunctival extramedullary plasmacytoma. (2350120)
1990
42
Extramedullary plasmacytoma of the testicle. Sonographic appearance and ultrasonically guided biopsy. (2198076)
1990
43
Anaplastic solitary extramedullary plasmacytoma of the cecum. Report of a case confirmed by immunoperoxidase staining. (3315510)
1987
44
Extramedullary plasmacytoma of the lung. (4005784)
1985
45
Extramedullary plasmacytoma of the bladder: a case report and review of literature. (7083118)
1982
46
Extramedullary plasmacytoma of the head and neck. (6792654)
1981
47
Extramedullary plasmacytoma of the parotid gland. (7359969)
1980
48
Mediastinal extramedullary plasmacytoma. (7375991)
1980
49
Extramedullary plasmacytoma of the gastrointestinal tract in a renal transplant recipient. (380262)
1979
50
Extramedullary plasmacytoma of the head and neck. (5659409)
1968

Variations for Plasmacytoma

About this section

Expression for genes affiliated with Plasmacytoma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Plasmacytoma

Search GEO for disease gene expression data for Plasmacytoma.

Pathways for genes affiliated with Plasmacytoma

About this section
Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 54QIAGEN, 5Cell Signaling Technology
See all sources

Pathways related to Plasmacytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6PRDM1, IL6
2
Show member pathways
9.6IL6, IRF4
3
Show member pathways
9.2B2M, IRF4, IL6
4
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.2IRF4, IL6, CD79B
59.1IRF4, AICDA
6
Show member pathways
9.1CD79B, IL6, STMN1
7
Show member pathways
8.9IL6, B2M, AICDA
88.8PRDM1, B2M, AICDA

Compounds for genes affiliated with Plasmacytoma

About this section
Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 62Tocris Bioscience, 30IUPHAR
See all sources

Compounds related to Plasmacytoma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1pamidronate46 52 1212.1IL6, B2M
2pmma4610.0B2M, IL6
32,5-oligoadenylate4610.0IL6, B2M
4neopterin469.9IL6, B2M
5rituximab46 52 1211.8IL6, B2M
6okt3469.7STMN1, IL6
7pge1469.7IL6, B2M
8dcmp46 2510.6B2M, AICDA
9ivig469.5IL6, AICDA
10thalidomide46 52 62 1212.5IL6, B2M
11cyclosporin a46 30 6211.4B2M, STMN1, IL6
12cytidine46 25 1211.4PRDM1, AICDA
13thymidine46 2510.3B2M, STMN1, IL6
14creatinine469.3IL6, STMN1, B2M
15cycloheximide468.9AICDA, B2M, IL6
16serine468.6CD27, CD79B, STMN1, B2M
17estrogen468.6IL6, STMN1, B2M, AICDA

GO Terms for genes affiliated with Plasmacytoma

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CD27, CD79B, IL6, B2M

Biological processes related to Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T-helper 17 cell lineage commitmentGO:0725409.7IL6, IRF4
2interferon-gamma-mediated signaling pathwayGO:0603339.6IRF4, B2M
3defense response to protozoanGO:0428329.6IL6, IRF4
4positive regulation of B cell differentiationGO:0455799.6CD27, PRDM1
5negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.3CD27, IL6
6cytokine-mediated signaling pathwayGO:0192219.1B2M, IRF4, IL6

Molecular functions related to Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.6CD27, CD79B
2protein bindingGO:0055157.1CD27, IL6, PRDM1, IRF4, B2M, AICDA

Products for genes affiliated with Plasmacytoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Plasmacytoma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet