MCID: PLS011
MIFTS: 52

Plasmacytoma malady

Cancer, Neuronal, Blood categories

Summaries for Plasmacytoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Plasmacytoma refers to a malignant plasma cell tumor growing within soft tissue or within the axial... more...

MalaCards: Plasmacytoma, also known as solitary plasmacytoma, is related to amyloidosis and adenoma. An important gene associated with Plasmacytoma is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Th17 Differentiation. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Classifications for Plasmacytoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal, Blood


Characteristics (Orphanet epidemiological data):

49
plasmacytoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

plasmacytoma 8 10 45 49 61
solitary plasmacytoma 8 49
myeloma - solitary 8
myeloma, solitary 8
solitary myeloma 8


External Ids:

Disease Ontology8 DOID:3721
MeSH35 D010954
NCIt40 C9349, C6932
MESH via Orphanet36 D010954
ICD10 via Orphanet26 C90.2
SNOMED-CT via Orphanet58 10639003, 415112005
UMLS via Orphanet62 C0032131
ICD1025 C90.3

Related Diseases for Plasmacytoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Plasmacytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis30.5IGKC, B2M
2adenoma30.0FST, IFI27, OSM, LIF
3hepatitis c29.8AICDA
4macroglobulinemia29.8B2M
5kaposi's sarcoma29.8IL6
6follicular lymphoma29.8CD27, CXCR5, AICDA
7arthritis29.8IL6ST, IL2RB, LIF, B2M, OSM, IL6
8extramedullary plasmacytoma11.2
9anaplastic plasmacytoma10.5
10solitary osseous plasmacytoma10.3
11plasma cell leukemia10.3
12extramedullary soft tissue plasmacytoma10.2
13poems syndrome10.2
14obstructive jaundice10.2
15t-cell leukemia10.2
16intussusception10.1
17solitary plasmacytoma of chest wall10.1
18castleman's disease10.1
19back pain10.1
20sinusitis10.0
21thyroid lymphoma10.0
22gastric lymphoma10.0
23chronic myeloid leukemia10.0
24adenocarcinoma10.0
25squamous cell carcinoma10.0
26thyroiditis10.0
27tuberculosis10.0
28post-transplant lymphoproliferative disease10.0
29plasmablastic lymphoma10.0
30primary plasmacytoma of the bone10.0
31multiple myeloma10.0IL6, B2M
32inflammatory bowel disease10.0IL6
33hepatitis10.0IL2RB
34uveitis10.0CXCR5
35pulmonary fibrosis10.0OSM
36galactosemia10.0IL6
37acquired immunodeficiency syndrome10.0B2M, IL6
38sjogren's syndrome10.0B2M
39lymphoma, malt, somatic10.0CXCR5, IGKC
40nephritis10.0LIF, B2M
41cervical intraepithelial neoplasia10.0IFI27
42peritonitis10.0B2M, LIF, IL6
43hypercalcemia10.0LIF, B2M
44anaplastic large cell lymphoma10.0IL2RB
45common variable immune deficiency10.0AICDA, IL2RB, CD27
46myelodysplastic syndromes10.0IL11
47sarcoidosis10.0CD27, IL2RB
48insulin resistance10.0FST, IL6
49myeloid leukemia10.0LIF, IL11, IL6ST
50sarcoma10.0STMN1, OSM

Graphical network of the top 20 diseases related to Plasmacytoma:



Diseases related to plasmacytoma

Clinical Features for Plasmacytoma

Drugs & Therapeutics for Plasmacytoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Plasmacytoma

Drug clinical trials:

Search ClinicalTrials for Plasmacytoma

Search NIH Clinical Center for Plasmacytoma

Search CenterWatch for Plasmacytoma

Genetic Tests for Plasmacytoma

Anatomical Context for Plasmacytoma

Animal Models for Plasmacytoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Plasmacytoma

Sources:
51PubMed
See all sources

Articles related to Plasmacytoma:

(show top 50)    (show all 859)
idTitleAuthorsYear
1
Extramedullary plasmacytoma in the lung of a Doberman pinscher dog. (24381343)
2014
2
Solitary plasmacytoma of the mandible - a rare entity. (24155610)
2013
3
A case of extramedullary plasmablastic plasmacytoma successfully treated using a combination of thalidomide and dexamethasone and a review of the medical literature. (23801130)
2013
4
Cranial plasmacytoma: a case series and review of the literature. (24426333)
2013
5
Plasmacytoma-like post-transplantation lymphoproliferative disorder confined to the renal allograft: a case report. (24034051)
2013
6
A rare cause of gastrointestinal bleeding. Multiple myeloma with extramedullary gastroduodenal plasmacytoma. (23900105)
2013
7
Cutaneous plasmacytoma. (23071470)
2012
8
Multicentric oral plasmacytoma in 3 dogs. (23008858)
2012
9
Primary isolated extramedullary plasmacytoma of mesentry: a rare case report. (22773223)
2012
10
Plasmacytoma-like post-transplantation lymphoproliferative disease occurring in a cardiac allograft: a case report and review of the literature. (22711849)
2012
11
Multi-institutional analysis of solitary extramedullary plasmacytoma of the head and neck treated with curative radiotherapy. (21277117)
2012
12
Atypical thoracic solitary plasmacytoma. (23185743)
2012
13
An aggressive extramedullary cutaneous plasmacytoma associated with extreme alterations in the innate immune system. (20215803)
2010
14
Aggressive and fatal extramedullary plasmacytoma: a report of two cases. (20477820)
2010
15
First report of a medullar cord compression secondary to osseous plasmacytoma successfully treated with bortezomib and dexamethasone. (19836836)
2010
16
Extramedullary plasmacytoma with a t(11;14)(q13;q32) and aggressive clinical course. (20496997)
2010
17
Cyclin D1 protein overexpression in extramedullary plasmacytoma: a clinicopathologic study of 11 cases. (19474518)
2009
18
Solitary extramedullary plasmacytoma of the vocal cord in an adolescent. (19858382)
2009
19
Mndal, a new interferon-inducible family member, is highly polymorphic, suppresses cell growth, and may modify plasmacytoma susceptibility. (19654412)
2009
20
Extramedullary plasmacytoma of the pancreas and jejunum. (19411034)
2009
21
Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report. (18291467)
2008
22
Solitary plasmacytoma of the upper cervical spine: therapeutic considerations. (18500219)
2008
23
Solitary plasmacytoma of the lung with coexisting sarcoid-like lesions. (17932670)
2008
24
Occult large epiphyseal solitary plasmacytoma at multidetector row computer tomography detected by magnetic resonance imaging. (19260386)
2008
25
Total and single doses influence the effectiveness of radiotherapy in palliative treatment of plasmacytoma. (19016025)
2008
26
Retroperitoneal plasmacytoma causing renal obstruction. (18188673)
2008
27
An extramedullary plasmacytoma originating from the thoracic spinal cord: magnetic resonance imaging findings. Case report. (17233292)
2007
28
Primary cutaneous plasmacytoma presenting with multiple subcutaneous nodules by F-18 FDG imaging. (17179817)
2007
29
Solitary extramedullary plasmacytoma of the liver without systemic monoclonal gammopathy. (17728524)
2007
30
Immunoglobulin free light chains and solitary plasmacytoma of bone. (16741249)
2006
31
Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma. (17119059)
2006
32
Primary cutaneous plasmacytoma (posttransplant lymphoproliferative disorder, plasmacytoma-like) in a heart transplant patient. (17012923)
2006
33
Plasmacytoma: an unusual cause of a pituitary mass lesion. A case report and a review of the literature. (16328566)
2004
34
Cavernous sinus involvement by extramedullary plasmacytoma of the sphenoid sinus. An argument for the use of adjuvant chemotherapy. (12481905)
2002
35
Extramedullary plasmacytoma in the nasal cavity. (12199164)
2002
36
Extramedullary plasmacytoma confined to the choroid. (11228316)
2001
37
Clinical outcome of extramedullary plasmacytoma. (10629591)
2000
38
Extramedullary plasmacytoma in a horse with ptyalism and dysphagia. (10826848)
2000
39
Polyradiculoneuropathy revealing a solitary plasmacytoma of the ilium. A new case-report. (10339780)
1999
40
MR characteristics of primary extramedullary plasmacytoma in the head and neck. (8871723)
1996
41
Solitary extramedullary plasmacytoma of the epiglottis: a case report and review of the literature. (7777365)
1995
42
IgG-kappa extramedullary plasmacytoma of the conjunctiva and orbit. (8494868)
1993
43
Extramedullary plasmacytoma of the larynx. (8288980)
1993
44
Extramedullary plasmacytoma producing biclonal gammopathy. (8400505)
1993
45
Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice. (1729694)
1992
46
Extramedullary plasmacytoma of the thyroid, associated with follicular colonization and stromal deposition of polytypic immunoglobulins and major histocompatibility antigens. Possible categorization in MALT lymphoma. (1476063)
1992
47
Extramedullary plasmacytoma (amyloid tumour) of the caruncle. (2663121)
1989
48
Anaplastic solitary extramedullary plasmacytoma of the cecum. Report of a case confirmed by immunoperoxidase staining. (3315510)
1987
49
Acute plasma cell leukaemia followed by extramedullary plasmacytoma. (7375811)
1980
50
Extramedullary plasmacytoma of the gastro-intestinal tract. (4502771)
1972

Genetic Variations for Plasmacytoma

Expression for genes affiliated with Plasmacytoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Plasmacytoma

Search GEO for disease gene expression data for Plasmacytoma.

Pathways for genes affiliated with Plasmacytoma

Sources:
54Reactome, 53R&D Systems, 12EMD Millipore, 4Cell Signaling Technology, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG
See all sources

Pathways related to Plasmacytoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3IL2RB, IL6ST, IL6
2
Hide members
10.3CXCR5, IL6, IL6ST
3
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
10.3IL6, IL6ST, OSM
410.3B2M, PRDM1, IL2RB, AICDA
510.3IL6ST, IL6, LIF, OSM
6
Hide members
10.3IL6, IL6ST, IL11, LIF
7
Hide members
10.2IL6, IL2RB, IL11, LIF, OSM
8
Hide members
10.2IL6, IL2RB, IL11, LIF, OSM
9
Hide members
10.2IL2RB, IL6ST, IFI27, IL6, B2M
10
Hide members
10.2IL6, STMN1, OSM, IL11, IL2RB, LIF
1110.2IL11, IL6ST, IL6, IL2RB, LIF, OSM
12
Hide members
10.1IL11, IL6ST, CXCR5, CD27, LIF, OSM
13
Hide members
10.1IFI27, B2M, IGKC, CD79B, IL2RB, IL6

Compounds for genes affiliated with Plasmacytoma

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 2BitterDB, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Plasmacytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.9IL2RB
2estrogen4510.9AICDA
3polyacrylonitrile4510.7B2M, LIF, IL2RB
4il 114510.7OSM, IL6, IL11, LIF
5filgrastim45 1111.7LIF, OSM, IL11, IL6
6endotoxin4510.7OSM, LIF, IL11
7cuprophan4510.7IL2RB, B2M, LIF
8creatinine4510.7FST, STMN1, IL2RB
9gm-csf45 2911.7LIF, IL11
10okt34510.7STMN1, IL2RB, IL6
11ifn-alpha4510.6IL6, IL6ST, IL2RB, OSM, LIF
12gp 1304510.6IL6ST, IL6, IL11, LIF, OSM
13azathioprine45 50 2 1113.6IL11, LIF, IL2RB, OSM
14tgf beta14510.6LIF, OSM, IL6, IL11, FST
151,25 dihydroxy vitamin d34510.6IL11, IL2RB, LIF, OSM
16calcitriol45 60 11 2413.6IL11, LIF, IFI27, B2M, IL6, CXCR5
17prostaglandin4510.6IL11, FST, OSM, IL6, LIF
18rantes4510.6LIF, IL6, IL2RB, IL11, CXCR5, OSM
192,5-oligoadenylate4510.6IL6, B2M, IL2RB
20cyclosporin a45 29 6012.6LIF, IL6, B2M, STMN1, IL11, IL2RB
21estradiol45 11 2412.6OSM, FST
22lactate4510.5IFI27, B2M, LIF, FST, IL6, IL2RB
23acth4510.5OSM, LIF, FST, IL2RB, IL6, IL6ST
24ribonucleic acid4510.5LIF, IL6ST, IL2RB, IL11, FST
25dexamethasone45 50 29 1113.5FST, IL6ST, OSM, IFI27, LIF, IL6
26vitamin d4510.5B2M, IL6ST, IL6, IL11, IFI27
27hyaluronic acid45 2411.5B2M, IL11, IL6, OSM
28pd 98,0594510.5IL6, LIF, IFI27, OSM, STMN1
29glucose4510.5IL11, LIF, FST, MPP1
30genistein45 29 60 2 11 2415.5IL2RB, LIF, B2M, OSM, FST, IFI27
31serine4510.5IL6ST, POU2F2, CD79B, IL2RB, OSM, STMN1
32thymidine45 2411.5OSM, STMN1, B2M, LIF, IL11, IL2RB
33progesterone45 60 29 11 2414.5FST, STMN1, IFI27, LIF, IL11, IL2RB
34phosphatidylinositol4510.4OSM, IFI27, IL11, CD79B, LIF, IL2RB
35etanercept45 50 1112.4IL2RB, IL11, IL6
36steroid4510.4POU2F2, LIF, IL11, IL2RB, FST, B2M
37cholesterol45 29 11 2413.4B2M, IL6, IL6ST, IL2RB, LIF, OSM
38vegf4510.4B2M, LIF, FST, IFI27, OSM, IL2RB
39threonine4510.4IL6ST, IL2RB, IL11, CD79B, STMN1, OSM
40txb24510.4B2M, LIF, IL11
41cysteine4510.4IL11, CD27, OSM, IGKC, LIF, B2M
42cdp5714510.4IL11, IL6
43forskolin45 50 1112.3LIF, FST, IL11, STMN1, OSM
44retinoic acid45 2411.3FST, IFI27, OSM, STMN1, B2M, LIF
45methylcellulose4510.3IL6, IL11, LIF
46oligonucleotide4510.3POU2F2, IFI27, IL11, STMN1, LIF, IL6ST
47calcium45 50 11 2413.3IFI27, IL6ST, FST, CD79B, CD27, LIF
48tyrosine4510.3IL6, IL6ST, FST, IL2RB, IL11, CD79B
49il 104510.2IL6, IL2RB, LIF
50infliximab45 50 1112.0IL2RB, IL11, IL6

GO Terms for genes affiliated with Plasmacytoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oncostatin-M receptor complexGO:00590010.3OSM, IL6ST
2interleukin-6 receptor complexGO:00589610.3IL6, IL6ST
3external side of plasma membraneGO:00989710.3B2M, IL6ST, IL6, IL2RB, CD79B, CD27
4extracellular regionGO:00557610.1IL6ST, IL6, IL11, CD27, IGKC, B2M
5extracellular spaceGO:0056159.9OSM, B2M, LIF, IL11, IL6, IL6ST

Biological processes related to Plasmacytoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of acute inflammatory responseGO:00267510.6IL6ST, OSM, IL6
2negative regulation of hormone secretionGO:04688810.6LIF, IL6, IL11, OSM
3positive regulation of peptidyl-serine phosphorylationGO:03313810.6IL6, IL11, LIF, OSM
4positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.5LIF, IL6, IL6ST
5positive regulation of MAPK cascadeGO:04341010.5IL11, IL6, OSM, LIF
6leukemia inhibitory factor signaling pathwayGO:04886110.5LIF, IL6ST
7positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5OSM, LIF, IL6, IL11
8tyrosine phosphorylation of Stat3 proteinGO:04250310.5LIF, OSM
9cytokine-mediated signaling pathwayGO:01922110.5IFI27, B2M, IL2RB, IL6, IL6ST
10interleukin-6-mediated signaling pathwayGO:07010210.4IL6ST, IL6
11immune responseGO:00695510.4LIF, OSM, IGKC, CD79B, CXCR5
12negative regulation of meiosisGO:04583510.4LIF, OSM
13positive regulation of B cell differentiationGO:04557910.4PRDM1, CD27
14positive regulation of cell proliferationGO:00828410.3IL6ST, IL6, IL11, LIF, OSM
15positive regulation of astrocyte differentiationGO:04871110.3LIF, IL6ST
16positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.1LIF, IL6ST

Molecular functions related to Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor bindingGO:00513810.4IL6ST, IL6
2growth factor activityGO:00808310.2OSM, LIF, IL11, IL6
3cytokine activityGO:00512510.0IL6, OSM, LIF, IL11

Products for genes affiliated with Plasmacytoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Plasmacytoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet