MCID: PLS011
MIFTS: 63

Plasmacytoma malady

Cancer diseases, Neuronal diseases, Blood diseases categories

Summaries for Plasmacytoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Plasmacytoma refers to a malignant plasma cell tumor growing within soft tissue or within the axial... more...

MalaCards: Plasmacytoma, also known as solitary plasmacytoma, is related to myeloma and multiple myeloma. An important gene associated with Plasmacytoma is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Th17 Differentiation. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and thyroid, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Classifications for Plasmacytoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

48
plasmacytoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

plasmacytoma 8 10 44 48 60
solitary plasmacytoma 8 48
myeloma - solitary 8
myeloma, solitary 8
solitary myeloma 8


External Ids:

Disease Ontology8 DOID:3721
MeSH34 D010954
NCIt39 C9349, C6932
MESH via Orphanet35 D010954
ICD10 via Orphanet26 C90.2
SNOMED-CT via Orphanet57 10639003, 415112005
UMLS via Orphanet61 C0032131
ICD1025 C90.3

Related Diseases for Plasmacytoma

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17GeneCards, 18GeneDecks
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Diseases related to Plasmacytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma31.2IFI27, IL6ST, IL6, IL11, OSM, B2M
2multiple myeloma31.1B2M, IL6
3amyloidosis30.4IGKC, B2M
4leukemia30.4IFI27, OSM, STMN1, B2M, PRDM1, LIF
5pancreatitis30.4IL6, IL11
6sarcoma30.1STMN1, OSM
7peritonitis29.9IL6, LIF, B2M
8sarcoidosis29.9CD27, IL2RB
9myeloid leukemia29.9LIF, IL11, IL6ST
10pituitary adenoma29.9IFI27, LIF, FST
11burkitt's lymphoma29.9IFI27, MPP1, AICDA, CD27, CXCR5
12adenoma29.9FST, LIF, OSM, IFI27
13hodgkin's lymphoma29.9STMN1, MPP1, PRDM1, AICDA, POU2F2, IL2RB
14hepatitis29.7IL2RB
15hepatitis c29.7AICDA
16macroglobulinemia29.7B2M
17kaposi's sarcoma29.7IL6
18arthritis29.7OSM, B2M, LIF, IL2RB, IL6, IL6ST
19hepatocellular carcinoma29.7IFI27, STMN1, AICDA, IL6, FST
20breast cancer29.7IFI27, OSM, STMN1, LIF, IL11, IL6ST
21melanoma29.7IFI27, OSM, STMN1, MPP1, CD27, IL2RB
22myelofibrosis29.7IL11, LIF
23extramedullary plasmacytoma11.1
24thyroiditis10.5
25cervicitis10.3
26anaplastic plasmacytoma10.3
27tonsillitis10.3
28solitary osseous plasmacytoma10.3
29mediastinitis10.3
30obstructive jaundice10.2
31poems syndrome10.2
32meningioma10.2
33plasma cell neoplasm10.2
34polyneuropathy10.1
35intussusception10.0
36duodenitis10.0
37solitary plasmacytoma of chest wall10.0
38marginal zone b-cell lymphoma10.0
39extramedullary soft tissue plasmacytoma10.0
40primary plasmacytoma of the bone10.0
41frontal sinusitis10.0
42inflammatory bowel disease10.0IL6
43uveitis10.0CXCR5
44pulmonary fibrosis10.0OSM
45galactosemia10.0IL6
46acquired immunodeficiency syndrome10.0B2M, IL6
47sjogren's syndrome10.0B2M
48malt lymphoma10.0IGKC, CXCR5
49nephritis10.0LIF, B2M
50cervical intraepithelial neoplasia10.0IFI27

Graphical network of the top 20 diseases related to Plasmacytoma:



Diseases related to plasmacytoma

Clinical Features for Plasmacytoma

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Drugs & Therapeutics for Plasmacytoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Plasmacytoma

Drug clinical trials:

Search ClinicalTrials for Plasmacytoma

Search NIH Clinical Center for Plasmacytoma

Search CenterWatch for Plasmacytoma

Genetic Tests for Plasmacytoma

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Anatomical Context for Plasmacytoma

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32MalaCards
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MalaCards organs/tissues related to Plasmacytoma:

32
Bone, Bone marrow, Thyroid, Breast, Colon, Skin, Lung, Lymph node, Pancreas, B cells, Liver, Tonsil, Kidney, Tongue, Heart, Small intestine, Testis, Brain, Salivary gland, Trachea, T cells, Ovary, Pituitary, Cervix, Adrenal gland, Spinal cord, Skeletal muscle, Endothelial, Myeloid, Prostate, Nk cells

Animal Models for Plasmacytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Plasmacytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.1PRDM1, LIF, IL2RB, IL6, IL6ST, FST
2MP:00053879.9IL6ST, B2M, MPP1, PRDM1, LIF, IGKC
3MP:00053979.9AICDA, IGKC, LIF, PRDM1, B2M, POU2F2
4MP:00107719.9OSM, LIF, AICDA, IL6, IL6ST, FST
5MP:00053849.7IGKC, LIF, PRDM1, MPP1, B2M, AICDA

Publications for Plasmacytoma

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50PubMed
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Articles related to Plasmacytoma:

(show top 50)    (show all 857)
idTitleAuthorsYear
1
A variant of AESOP syndrome (adenopathy and extensive skin patch overlying a plasmacytoma)--reply. (24048432)
2013
2
(18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging of extra-medullary plasmacytoma of the ovary. (24250033)
2013
3
Primary cutaneous plasmacytoma occurring after pacemaker implantation and recurring in scar tissue. (23473273)
2013
4
Isolated Peritoneal Donor-Related Plasmacytoma 3 Years After Liver Transplantation: A Case Report. (24373189)
2013
5
Extramedullary Plasmacytoma of the Trachea. (24046059)
2013
6
Gastric recurrence of a primary colon plasmacytoma: staging and evaluating response to therapy with 18F-FDG PET/CT. (22190759)
2012
7
Pulmonary plasmacytoma. (22722793)
2012
8
Plasmacytoma of the skull. (22082085)
2012
9
Polyclonal rabbit anti-murine plasmacytoma cell globulins induce myeloma cells apoptosis and inhibit tumour growth in mice. (21197579)
2011
10
Relapsed multiple myeloma presenting as an orbital plasmacytoma. (22072197)
2011
11
Development of POEMS syndrome after an initial manifestation of solitary plasmacytoma. (21553018)
2011
12
Paratesticular solitary plasmacytoma. (22184545)
2011
13
Solitary extramedullary plasmacytoma of the thyroid gland associated with multinodular goiter: case report and review of the literature. (22007566)
2011
14
An unusual case of IgE-multiple myeloma presenting with systemic amyloidosis 2 years after cervical plasmacytoma resection. (20697853)
2010
15
Primary pulmonary plasmacytoma with diffuse alveolar consolidation: a case report. (21151727)
2010
16
Recurrent multiple myeloma presenting as a breast plasmacytoma. (21939175)
2010
17
Solitary plasmacytoma of the jaw. (22282681)
2010
18
Clinical features and differential diagnoses of solitary extramedullary plasmacytoma of the thyroid: a case report. (19302961)
2009
19
A rare case of solitary plasmacytoma mimicking a primary lung tumor. (19324112)
2009
20
Dural plasmacytoma mimicking meningioma in a young patient with multiple myeloma. (21611030)
2009
21
Plasmacytoma with amyloidosis masquerding as tuberculosis on cytology. (21938185)
2009
22
A pleural effusion due to extramedullary pleural plasmacytoma: a case report. (18265936)
2008
23
Primary plasmacytoma of the uterine cervix treated with three-dimensional conformal radiotherapy. (19122936)
2008
24
Extramedullary plasmacytoma presenting as a nasal mass in an immunosuppressed patient: treatment after failed primary radiotherapy. (18478798)
2008
25
Solitary extramedullary plasmacytoma of the canine larynx. (17425696)
2007
26
Plasmacytoma of the clivus: a case report. (17183858)
2006
27
Highly vascular solitary plasmacytoma of the calvarium. (16512823)
2006
28
Gastric involvement of plasmacytoma associated with t(4:14) and chromosome 13 deletion. (17065017)
2006
29
Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. (15586381)
2005
30
CT and MRI findings of a solitary extramedullary plasmacytoma of the oropharynx: case report. (16555568)
2005
31
Radiotherapy in the management of solitary extramedullary plasmacytoma. (15836498)
2005
32
Extramedullary plasmacytoma presenting as a primary mass in the breast. A case report. (14674091)
2003
33
Congo red-positive cardiac kappa-AL amyloidosis in plasmacytoma -- case report and review of the literature. (12558564)
2003
34
Primary marginal zone B-cell lymphoma of the lymph node resembling plasmacytoma arising from a plasma cell variant of Castleman's disease. A clinicopathological and immunohistochemical study of seven patients. (12645666)
2002
35
Extramedullary plasmacytoma of the hand: a case report. (11466658)
2001
36
Metastatic cutaneous plasmacytoma: a case report associated with IgA lambda multiple myeloma and a review of the literature of metastatic cutaneous plasmacytomas associated with multiple myeloma and primary cutaneous plasmacytomas. (10535253)
1999
37
Plasma cell leukemia evolving into aggressive extramedullary plasmacytoma by clonal selection. (9256296)
1997
38
Endobronchial extramedullary plasmacytoma. Report of one case. (9017589)
1996
39
Persistent growth of BALB/C mouse plasmacytoma and human myeloma cell lines in the presence of phorbol myristate acetate is associated with continued expression of Lap18 (stathmin). (7750926)
1995
40
Fine-needle aspiration of pancreatic extramedullary plasmacytoma: possible confusion with islet cell tumor. (7924813)
1994
41
Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. (7958890)
1994
42
Unusual presentations of extramedullary plasmacytoma in the head and neck. (3343553)
1988
43
Cutaneous involvement of multiple myeloma and extramedullary plasmacytoma. (2461399)
1988
44
Immunoperoxidase characterization of extramedullary plasmacytoma of the head and neck. (3305425)
1987
45
Extramedullary plasmacytoma in the head and neck: report of 10 cases. (3938383)
1985
46
Extramedullary plasmacytoma of the upper respiratory passages. (893174)
1977
47
Solitary extramedullary plasmacytoma of the skin. A review of the world literature and the report of an addiional case. (5424538)
1970
48
Extramedullary plasmacytoma of the head and neck. (5659409)
1968
49
Gastric myeloma: case report of extramedullary plasmacytoma and review of literature. (5294854)
1966
50
Extramedullary plasmacytoma of the upper air passages. (13773743)
1960

Genetic Variations for Plasmacytoma

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Expression for genes affiliated with Plasmacytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plasmacytoma

Search GEO for disease gene expression data for Plasmacytoma.

Pathways for genes affiliated with Plasmacytoma

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Sources:
53Reactome, 52R&D Systems, 12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG
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Pathways related to Plasmacytoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3IL6ST, IL6, IL2RB
2
Hide members
10.3CXCR5, IL6, IL6ST
3
Immune response Oncostatin M signaling via JAK-Stat in human cells
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10.3OSM, IL6, IL6ST
410.3IL2RB, AICDA, PRDM1, B2M
510.3OSM, LIF, IL6, IL6ST
6
Hide members
10.3IL6ST, IL6, IL11, LIF
7
Hide members
10.2OSM, LIF, IL11, IL2RB, IL6
8
Hide members
10.2IL2RB, IL11, LIF, OSM, IL6
9
Hide members
10.2IL6ST, IL6, IL2RB, B2M, IFI27
10
Hide members
10.2OSM, STMN1, LIF, IL11, IL2RB, IL6
1110.2IL6ST, IL6, IL2RB, IL11, LIF, OSM
12
Hide members
10.1OSM, LIF, CD27, CXCR5, IL11, IL6ST
13
Hide members
10.1IFI27, B2M, IGKC, CD79B, IL2RB, IL6

Compounds for genes affiliated with Plasmacytoma

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44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Plasmacytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.9IL2RB
2estrogen4410.9AICDA
3polyacrylonitrile4410.7B2M, LIF, IL2RB
4il 114410.7OSM, LIF, IL11, IL6
5filgrastim44 1111.7OSM, LIF, IL11, IL6
6endotoxin4410.7OSM, LIF, IL11
7cuprophan4410.7IL2RB, LIF, B2M
8creatinine4410.7FST, IL2RB, STMN1
9gm-csf44 2811.7IL11, LIF
10okt34410.7STMN1, IL2RB, IL6
11ifn-alpha4410.6OSM, LIF, IL2RB, IL6, IL6ST
12gp 1304410.6OSM, LIF, IL11, IL6, IL6ST
13azathioprine44 49 2 1113.6IL2RB, IL11, LIF, OSM
14tgf beta14410.6FST, IL6, IL11, LIF, OSM
151,25 dihydroxy vitamin d34410.6OSM, LIF, IL11, IL2RB
16calcitriol44 59 11 2413.6IFI27, B2M, LIF, CXCR5, IL11, IL6
17prostaglandin4410.6FST, IL6, IL11, LIF, OSM
18rantes4410.6OSM, LIF, CXCR5, IL11, IL2RB, IL6
192,5-oligoadenylate4410.6B2M, IL2RB, IL6
20cyclosporin a44 28 5912.6STMN1, B2M, LIF, IL11, IL2RB, IL6
21estradiol44 11 2412.6FST, OSM
22lactate4410.5IFI27, B2M, LIF, IL2RB, IL6, FST
23acth4410.5OSM, LIF, IL11, IL2RB, IL6, IL6ST
24ribonucleic acid4410.5LIF, IL11, IL2RB, IL6ST, FST
25dexamethasone44 49 28 1113.5IFI27, OSM, LIF, IL6, IL6ST, FST
26vitamin d4410.5IFI27, B2M, IL11, IL6, IL6ST
27hyaluronic acid44 2411.5IL6, IL11, B2M, OSM
28pd 98,0594410.5IFI27, OSM, STMN1, LIF, IL6
29glucose4410.5MPP1, LIF, IL11, FST
30genistein44 28 59 2 11 2415.5IFI27, OSM, B2M, LIF, IL2RB, IL6
31serine4410.5OSM, STMN1, B2M, LIF, POU2F2, CD79B
32thymidine44 2411.5IFI27, OSM, STMN1, B2M, LIF, IL11
33progesterone44 59 28 11 2414.5IFI27, STMN1, LIF, IL11, IL2RB, IL6ST
34phosphatidylinositol4410.4IFI27, OSM, LIF, CD79B, IL11, IL2RB
35etanercept44 49 1112.4IL11, IL2RB, IL6
36steroid4410.4IFI27, OSM, B2M, LIF, POU2F2, IL11
37cholesterol44 28 11 2413.4OSM, B2M, LIF, IL2RB, IL6, IL6ST
38vegf4410.4IFI27, OSM, B2M, LIF, IL11, IL2RB
39threonine4410.4IFI27, OSM, STMN1, CD79B, IL11, IL2RB
40txb24410.4IL11, LIF, B2M
41cysteine4410.4OSM, B2M, LIF, IGKC, CD27, IL11
42cdp5714410.4IL6, IL11
43forskolin44 49 1112.3FST, IL11, LIF, STMN1, OSM
44retinoic acid44 2411.3FST, IFI27, OSM, STMN1, B2M, LIF
45methylcellulose4410.3IL6, IL11, LIF
46oligonucleotide4410.3IFI27, STMN1, LIF, POU2F2, IL11, IL6ST
47calcium44 49 11 2413.3IFI27, OSM, STMN1, B2M, LIF, CD27
48tyrosine4410.3LIF, MPP1, STMN1, OSM, IFI27, POU2F2
49il 104410.2LIF, IL2RB, IL6
50infliximab44 49 1112.0IL6, IL2RB, IL11

GO Terms for genes affiliated with Plasmacytoma

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16Gene Ontology
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Cellular components related to Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oncostatin-M receptor complexGO:00590010.3OSM, IL6ST
2interleukin-6 receptor complexGO:00589610.3IL6, IL6ST
3external side of plasma membraneGO:00989710.3IL6ST, IL6, IL2RB, CD79B, CD27, B2M
4extracellular regionGO:00557610.1IGKC, CD27, IL11, IL6, IL6ST, FST
5extracellular spaceGO:0056159.9OSM, B2M, LIF, IL11, IL6, IL6ST

Biological processes related to Plasmacytoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of acute inflammatory responseGO:00267510.6OSM, IL6, IL6ST
2negative regulation of hormone secretionGO:04688810.6IL6, IL11, LIF, OSM
3positive regulation of peptidyl-serine phosphorylationGO:03313810.6IL6, IL11, LIF, OSM
4positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.5LIF, IL6, IL6ST
5positive regulation of MAPK cascadeGO:04341010.5OSM, LIF, IL11, IL6
6leukemia inhibitory factor signaling pathwayGO:04886110.5LIF, IL6ST
7positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5IL6, IL11, LIF, OSM
8tyrosine phosphorylation of Stat3 proteinGO:04250310.5LIF, OSM
9cytokine-mediated signaling pathwayGO:01922110.5IFI27, B2M, IL2RB, IL6, IL6ST
10negative regulation of meiosisGO:04583510.4LIF, OSM
11immune responseGO:00695510.4CXCR5, CD79B, IGKC, LIF, OSM
12interleukin-6-mediated signaling pathwayGO:07010210.4IL6ST, IL6
13positive regulation of B cell differentiationGO:04557910.4CD27, PRDM1
14positive regulation of cell proliferationGO:00828410.3OSM, LIF, IL11, IL6, IL6ST
15positive regulation of astrocyte differentiationGO:04871110.3LIF, IL6ST
16positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.1LIF, IL6ST

Molecular functions related to Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor bindingGO:00513810.4IL6ST, IL6
2growth factor activityGO:00808310.2IL6, IL11, LIF, OSM
3cytokine activityGO:00512510.0OSM, LIF, IL11, IL6

Products for genes affiliated with Plasmacytoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Plasmacytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet