Plasmacytoma malady

Wikipedia: Plasmacytoma refers to a malignant plasma cell tumor growing within soft tissue or within the skeleton....⁴⁴ more...

MalaCards: Plasmacytoma, also known as solitary plasmacytoma, is related to monoclonal gammopathy of undetermined significance and multiple myeloma. An important gene associated with Plasmacytoma is CNTN3 (contactin 3 (plasmacytoma associated)), and among its related pathways are Primary immunodeficiency and Immune response Oncostatin M signaling via JAK-Stat in human cells. The drugs zoledronic and carmustine and the compounds cyclophosphamide and threonine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, nk cells and t cells, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Aliases & Descriptions:

plasmacytoma 6 8 32 43 solitary plasmacytoma 6 myeloma - solitary 6

myeloma, solitary 6 solitary myeloma 6 multiple myeloma 43

Diseases related to plasmacytoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 615)

id	Related Disease	Score	Top Affiliating Genes
1	monoclonal gammopathy of undetermined significance	34.4	B2M, CD79A, CDKN2B, IL6, IL6R, CCL3
2	multiple myeloma	33.3	BCL2L1, ITGA4, IL6, CCND1
3	plasma cell leukemia	33.1	CD40, IRF4, IL6, CCND1, IGH@
4	hodgkin's lymphoma	33.1	BLZF1, PAX5, BCL2, BCL2L1, BCL6, MPP1
5	hypercalcemia	32.3	LIF, B2M, IRF4, IL2, IL2RB, IL6
6	non-hodgkin lymphoma	32.0	MYC, PAX5, BCL2, BCL2L1, BCL6, B2M
7	anaplastic plasmacytoma	32.0	MYC, IFI27, TNFRSF8
8	extramedullary plasmacytoma	31.6	ZNF347, VEGFA, BCL2, BCL2L1, ZBTB20, B2M
9	plasma cell neoplasm	31.4	MYC, IL6, AICDA
10	t-cell leukemia	31.3	MYC, BLZF1, BCL2, BCL2L1, XBP1, CD40
11	osteolysis	30.8	VEGFA, IL11, IL2, IL4, IL6, CCL3
12	mantle cell lymphoma	30.6	BCL2, BCL6, CCND1
13	chronic lymphocytic leukemia	30.3	BLZF1, PAX5, BCL2, BCL2L1, BCL6, B2M
14	pituitary tumor	29.9	VEGFA, MYC, LIF, FST, CDKN1A, IL6
15	paraproteinemia	29.5	VEGFA, CD79A, IL6
16	macroglobulinemia	29.2	VEGFA, PAX5, BCL2, MTOR, XBP1, B2M
17	thrombosis	29.0	VEGFA, MUC1, MPO, CD79A, CD40, IL2
18	waldenstrom macroglobulinemia	28.9	VEGFA, PAX5, BCL2, MTOR, XBP1, CD27
19	clostridium difficile	28.8	BCL2, CD79A, CDKN1A, IL11
20	hyperlipidemia	28.7	LIF, MPO, CD79A, ITGA4, IL6, CCL3
21	graft versus host disease	28.5	IL11, IL2, IL2RB, IL4
22	essential thrombocythemia	28.4	MYC, BCL2L1, MPO, IL11, IL6R, IL6ST
23	cryoglobulinemia	28.3	BCL2, CD79A, CD27, CD5, IL4
24	histiocytosis	28.1	LIF, CD40, IL11, IL2, IL4, IGKC
25	thrombocytosis	28.1	VEGFA, LIF, CD79A, IL11, IL4, IL6
26	measles	28.1	CIITA, CD79A, IL2, IL2RB, IL4, IL6
27	fanconi's anemia	28.0	BLZF1, BCL2, CD79A, CDKN1A, CD34, IL6
28	thrombocytopenia	27.9	CD79A, CDKN1A, CDKN2B, CD34, CD5, IL11
29	retinoblastoma	27.8	VEGFA, MYC, PAX5, BCL2, BCL2L1, MUC1
30	wilms tumor	27.5	VEGFA, MYC, BCL2, BCL2L1, MUC1, ITGA4
31	myelodysplastic syndrome	27.5	BTK, VEGFA, MYC, BCL2, BCL6, B2M
32	neutropenia	27.3	BTK, LIF, BLZF1, BCL2, MPO, CD79A
33	burkitt's lymphoma	27.2	MYC, PAX5, BCL2, BCL2L1, BCL6, MPP1
34	sepsis	27.1	BLZF1, CIITA, MPO, ITGA4, IL11, IL6
35	liver cancer	27.0	VEGFA, MYC, LIF, BCL2, BCL2L1, CDKN1A
36	celiac disease	26.7	CIITA, CD79A, ITGA4, IRF4, IL2, IL4
37	amyotrophic lateral sclerosis	26.7	CNTN4, CNTN6, VEGFA, LIF, BCL2, BCL2L1
38	lateral sclerosis	26.7	CNTN4, CNTN6, VEGFA, LIF, BCL2, BCL2L1
39	pemphigus	26.7	BLZF1, CIITA, MTOR, CD79A, CD40, IL2
40	hemochromatosis	26.6	B2M, MPO, IL6, HP, NOS2
41	amyloidosis	26.6	PCSK5, BCL2, B2M, CD79A, CD40, IRF4
42	b-cell non-hodgkin lymphoma	26.5	VEGFA, MYC, PAX5, BCL2, BCL2L1, BCL6
43	immunodeficiency	26.3	BTK, BLZF1, CIITA, CD79A, CD40, ITGA4
44	bladder carcinoma	26.1	VEGFA, MYC, PAX5, BCL2, BCL2L1, MUC1
45	leukemia/lymphoma	26.0	VEGFA, MYC, PAX5, BCL2, BCL6, MUC1
46	meningitis	25.6	BTK, VEGFA, MUC1, B2M, MPO, FST
47	chronic myeloid leukemia	25.6	MYC, BLZF1, BCL2, BCL2L1, MPO, CDKN1A
48	diffuse large b-cell lymphoma	25.3	VEGFA, MYC, PAX5, BCL2, BCL2L1, BCL6
49	lymphocytic leukemia	25.2	BTK, VEGFA, MYC, BLZF1, PAX5, BCL2
50	b-cell lymphomas	25.0	BTK, MYC, BLZF1, PAX5, BCL2, BCL2L1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 aldesleukin, bortezomib, carmustine, cisplatin, cisplatin pwdr [va product], cyclophosphamide, doxorubicin hydrochloride, interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, melphalan, melphalan hydrochloride, peginterferon alfa-2a, peginterferon alfa-2b, procarbazine, procarbazine hydrochloride, thalidomide, zoledronic, zoledronic acid

MalaCards organs/tissues related to plasmacytoma:

²²

MGI Mouse Phenotypes related to plasmacytoma:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.3	PRDM1, IL2RB, IL2, CDKN2B
2	respiratory system phenotype	MP:0005388	9.7	POU2F2, PTPRC, FST, BCL6, LIF, PCSK5
3	craniofacial phenotype	MP:0005382	9.3	PRDM1, SPI1, ITGA4, FST, PCSK5
4	liver/biliary system phenotype	MP:0005370	9.1	EBF1, SPI1, PTPRC, IL6, IL2, IRF8
5	renal/urinary system phenotype	MP:0005367	8.8	PTPRC, HRAS, CDKN2B, CDKN1A, MTOR, BCL2
6	no phenotypic analysis	MP:0003012	8.6	PRDM1, PVT1, SPI1, AICDA, HRAS, IGKC
7	adipose tissue phenotype	MP:0005375	8.4	NOS2, IL6R, IL6, CDKN1A, MTOR, BCL2
8	skeleton phenotype	MP:0005390	8.2	IL6ST, CCND1, HRAS, PTPRC, SPI1, EBF1
9	hematopoietic system phenotype	MP:0005397	8.2	BTK, BCL2, BCL2L1, XBP1, CDKN1A, CD27
10	reproductive system phenotype	MP:0005389	8.2	IL6, IL6ST, CCND1, HRAS, NOS2, IL4
11	normal phenotype	MP:0002873	7.8	IL6ST, HRAS, AICDA, PTPRC, SPI1, NOTCH4
12	integument phenotype	MP:0010771	7.8	IL2RB, IL4, IL6ST, MAEA, CCND1, HRAS
13	digestive/alimentary phenotype	MP:0005381	7.6	CDKN1A, IL6ST, CCL3, AICDA, PTPRC, NOS2
14	muscle phenotype	MP:0005369	7.5	CDKN1A, IL6, NOS2, STMN1, PRDM1, EEF1A2
15	nervous system phenotype	MP:0003631	7.5	CCND1, CCL3, HRAS, PTPRC, SPI1, NOTCH4
16	behavior/neurological phenotype	MP:0005386	7.2	IL6R, CCL3, HRAS, NOS2, OSM, POU2F2
17	tumorigenesis	MP:0002006	7.2	IL6, IL6ST, CCND1, HRAS, HP, AICDA
18	immune system phenotype	MP:0005387	7.1	PCSK5, CCL3, TNFRSF8, PTPRC, SPI1, PRDM1
19	cardiovascular system phenotype	MP:0005385	6.7	IL2, IL6, IL6ST, CCND1, HRAS, HP
20	growth/size phenotype	MP:0005378	6.6	CCND1, MAEA, IL6, IL2RB, IL2, HRAS
21	mortality/aging	MP:0010768	5.9	IL6ST, MAEA, CCND1, CCL3, HRAS, HP
22	homeostasis/metabolism phenotype	MP:0005376	4.7	BTK, VEGFA, MYC, CD40, FEV, IL6R
23	cellular phenotype	MP:0005384	4.2	CDKN1A, IGKC, HP, AICDA, TNFRSF8, PTPRC

Articles related to plasmacytoma:

(show top 50)    (show all 58)

id	Title	Authors	Year	Affiliating Genes
1	Functional characterization of the plasmacytoma varia nt translocation 1 gene (PVT1) in diabetic nephropathy. (21526116)	Alvarez M.L.... Distefano J.K.	2011	PVT1
2	Eef1a2 promotes cell growth, inhibits apoptosis and a ctivates JAK/STAT and AKT signaling in mouse plasmacytomas. (20505761)	Li Z.... Morse H.C.	2010	EEF1A2
3	Biological impact of vascular endothelial growth fact or on vessel density and survival in multiple myeloma and plasmacytoma. (20709463)	Swelam W.M.... Al Tamimi D.M.	2010	VEGFA
4	Mouse plasmacytoma-expressed transcript 1 knock out i nduced 5-HT disruption results in a lack of cognitive deficits and an anxiety p henotype complicated by hypoactivity and defensiveness. (19786075)	Schaefer T.L.... Williams M.T.	2009	FEV
5	Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. (17363561)	Qi C.F.... Morse H.C.	2007	IL6
6	Variants in the plasmacytoma variant translocation gene (PVT1) are associated with end-stage renal disease attributed to type 1 diabetes. (17881614)	Millis M.P.... Wolford J.K.	2007	PVT1
7	Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma. (17119059)	Cozen W.... Ingles S.A.	2006	IL6
8	Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. (15586381)	Kremer M.... Fend F.	2005	BCL2, CCND1, BCL2L1
9	Up-date on solitary plasmacytoma and its main differences with multiple myeloma. (15812350)	Di Micco P.... Di Micco B.	2005	B2M
10	Extraosseous IL-6 transgenic mouse plasmacytoma sometimes lacks Myc-activating chromosomal translocation. (15751044)	McNeil N.... Janz S.	2005	MYC, IL6
11	Insights into extramedullary tumour cell growth revealed by expression profiling of human plasmacytomas and multiple myeloma. (12930383)	Hedvat C.V.... Nimer S.D.	2003	NOTCH4
12	A case of Crow-Fukase syndrome with extramedullary plasmacytoma: marked clinical deterioration following a biopsy to plasmacytoma (12884826)	Takakura Y.... Miyoshi T.	2003	VEGFA
13	Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene. (14634209)	Bliskovsky V.... Mock B.A.	2003	MTOR
14	A nitric oxide synthase inhibitor, N(G)-nitro-l-argin ine-methyl-ester, exerts potent antiangiogenic effects on plasmacytoma in a new ly established multiple myeloma severe combined immunodeficient mouse model. (12580953)	Uneda S.... Mitsuya H.	2003	NOS2
15	IL-6 transgenic mouse model for extraosseous plasmacytoma. (11805288)	Kovalchuk A.L.... Janz S.	2002	IL6
16	Vascular endothelial growth factor (VEGF) expression in plasmacytoma. (11908718)	Paydas S.... Tuncer I.	2002	VEGFA
17	Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma. (11920233)	Burger R.... Gramatzki M.	2001	IL6ST
18	A patient with Crow-Fukase syndrome associated with pulmonary plasmacytoma (11481854)	Shinde A.... Shibasaki H.	2001	VEGFA
19	Translocation remodeling in the primary BALB/c plasmacytoma TEPC 3610. (11170286)	Kovalchuk A.L.... Janz S.	2001	MYC
20	Localized amyloidosis and extramedullary plasmacytoma involving the larynx of a child. (11172308)	Nagasaka T.... Nakashima N.	2001	IGKC
21	Extramedullary primary cutaneous plasmacytoma. Description of a case] . (11072738)	Turitto G.... Iaffaioli R.V.	2000	B2M
22	Defensins are dominant HLA-DR-associated self-peptide s from CD34(-) peripheral blood mononuclear cells of different tumor patients ( plasmacytoma, chronic myeloid leukemia). (10779436)	Halder T.M.... Kalbacher H.	2000	CD34
23	Deregulated expression of c-Myc in a translocation-negative plasmacytoma on extrachromosomal elements that carry IgH and myc genes. (10570182)	Wiener F.... Mai S.	1999	MYC, IGH@
24	Primary gastric plasmacytoma: a rare cause of hypertrophic gastritis in an adolescent. (10512402)	Goyal A.... Perlmutter D.H.	1999	IL6
25	Metastatic cutaneous plasmacytoma: a case report associated with IgA lambda multiple myeloma and a review of the literature of metastatic cutaneous plasmacytomas associated with multiple myeloma and primary cutaneous plasmacytomas. (10535253)	Kato N.... Aikawa K.	1999	CD79A
26	Cleaved variant of plasmacytoma with myelomonocytic d ifferentiation--immunohistochemical and ultrastructural studies. (9364303)	Go J.H.... Ree H.J.	1997	MPO
27	A mechanism for selective recruitment of CD8 T cells into B7-1-transfected plasmacytoma: role of macrophage-inflammatory protein 1alpha. (9200474)	Maric M.... Liu Y.	1997	CCL3
28	Genetic recombinations between c-myc and Igh mu as precursors for recombinations between c-myc and Igh alpha in BALB/c plasmacytomas. (9308247)	Janz S.... Potter M.	1997	MYC
29	Concomitant downregulation of IgH 3' enhancer activity and c-myc expression in a plasmacytoma x fibroblast environment: implications for dysregulation of translocated c-myc. (9188842)	ThA... Junker S.	1997	MYC
30	Role of interleukin-6 in the pathogenesis of murine plasmacytoma and human multiple myeloma. (9284811)	Pattengale P.K.	1997	IL6
31	Increased plasma interleukin-6 in cutaneous plasmacytoma: the effect of intralesional steroid therapy. (9390345)	Yamamoto T.... Nishioka K.	1997	IL6
32	Multiple cytokines inhibit interleukin-6-dependent murine hybridoma/plasmacytoma proliferation. (8599834)	Schwabe M.... Kung H.F.	1996	IL6, OSM
33	Ig/myc translocations of the plasmacytoma-prone BALB/c strain occur independently of the genetic and parental origin of the affected chromosomes 6, 12, and 15. (8946197)	Silva S.... Klein G.	1996	MYC
34	Plasmacytoma-associated neuronal glycoprotein, Pang, maps to mouse chromosome 6 and human chromosome 3. (8661054)	Mock B.A.... Marcu K.B.	1996	CNTN3
35	Early B-cell factor (EBF) down-regulates immunoglobulin heavy chain intron enhancer function in a plasmacytoma cell line. (8693297)	Akerblad P.... Leanderson T.	1996	EBF1
36	The plasmacytoma growth inhibitor restrictin-P is an antagonist of interleukin 6 and interleukin 11. Identification as a stroma-derived activin A. (7494003)	Brosh N.... Carmi P.	1995	IL6, IL11
37	Persistent growth of BALB/C mouse plasmacytoma and human myeloma cell lines in the presence of phorbol myristate acetate is associated with continued expression of Lap18 (stathmin). (7750926)	Jones N.A.... Brown G.	1995	STMN1
38	The proliferation-associated cytosolic protein Lap18 (stathmin) is expressed at atypically low levels in BALB/c plasmacytoma cells. (7895523)	Rowlands D.C.... MacLennan I.C.	1995	STMN1
39	Cytokines, immunoglobulins, and IgG subclasses in patients with IgG plasmacytomas (7927479)	Klouche M.... Kirchner H.	1994	IL4
40	Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130. (8145046)	Nishimoto N.... Kishimoto T.	1994	IL6, IL6R, IL6ST
41	Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. (7958890)	Madisen L.... Groudine M.	1994	MYC
42	Solitary plasmacytoma of bone and extramedullary plasmacytoma: two different nosological entities? (7839469)	Guida M.... De Lena M.	1994	IL6, IL2, B2M
43	The increase of CD5LOW+NK cells in patients with multiple myeloma and plasmacytoma. (7516640)	Ishiyama T.... Tsuruoka N.	1994	CD5
44	Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas. (8220424)	Bhatia K.... Magrath I.	1993	MYC
45	The role of idiotype-specific, CD4+ T cells in tumor resistance against major histocompatibility complex class II molecule negative plasmacytoma cells. (8098665)	Lauritzsen G.F.... Bogen B.	1993	CIITA
46	Interleukin-6 in myeloma/plasmacytoma. (8454420)	Suematsu S.... Kishimoto T.	1993	IL6
47	Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice. (1729694)	Suematsu S.... Kishimoto T.	1992	IL6
48	Reactivation of a major histocompatibility complex class II gene in mouse plasmacytoma cells and mouse T cells. (1402690)	Chang C.H.... Flavell R.A.	1992	CIITA
49	A new variant 15; 16 translocation in mouse plasmacytoma leads to the juxtaposition of c-myc and immunoglobulin lambda. (1766673)	Axelson H.... Sumegi J.	1991	MYC
50	Interleukin-2 receptor antigen, leukocyte common antigen, and Ki-1 antigen-expressing gastric plasmacytoma. A case report with an immunohistochemical study. (1700575)	Ohmori T.... Iwahashi K.	1990	PTPRC

Genes related to plasmacytoma according to GeneCards:

(show top 50)    (show all 67)

id	Symbol	Description	Score	GeneCards Section Context
1	CNTN3	contactin 3 (plasmacytoma associated)	11.1	Aliases & Descriptions, Transcripts, Publications, Orthologs
2	IGKC	immunoglobulin kappa constant	11.0	Publications
3	B2M	beta-2-microglobulin	11.0	Publications
4	IL6	interleukin 6 (interferon, beta 2)	11.0	Functions, Publications
5	MAEA	macrophage erythroblast attacher	11.0
6	CD79B	CD79b molecule, immunoglobulin-associated beta	11.0
7	MPP1	membrane protein, palmitoylated 1, 55kDa	11.0
8	CXCR5	chemokine (C-X-C motif) receptor 5	11.0
9	FST	follistatin	11.0
10	AICDA	activation-induced cytidine deaminase	11.0
11	CD27	CD27 molecule	11.0
12	POU2F2	POU class 2 homeobox 2	11.0
13	PRDM1	PR domain containing 1, with ZNF domain	11.0
14	OSM	oncostatin M	11.0	Publications
15	IRF4	interferon regulatory factor 4	11.0
16	STMN1	stathmin 1	11.0	Publications
17	XBP1	X-box binding protein 1	11.0
18	IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	11.0	Publications
19	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
20	IGH@	immunoglobulin heavy locus	11.0	Publications
21	IL11	interleukin 11	11.0	Publications
22	IL2RB	interleukin 2 receptor, beta	11.0	Publications
23	CIITA	class II, major histocompatibility complex, transactivator	11.0	Publications
24	SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	11.0
25	BCL6	B-cell CLL/lymphoma 6	11.0
26	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0
27	LIF	leukemia inhibitory factor	11.0	Publications
28	IL6R	interleukin 6 receptor	11.0	Publications
29	BTK	Bruton agammaglobulinemia tyrosine kinase	11.0
30	LIFR	leukemia inhibitory factor receptor alpha	11.0
31	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
32	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0
33	PAX5	paired box 5	11.0
34	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
35	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	11.0
36	PTPRC	protein tyrosine phosphatase, receptor type, C	11.0	Publications
37	BCL2L1	BCL2-like 1	11.0	Publications
38	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0
39	EBF1	early B-cell factor 1	11.0	Publications
40	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0
41	VEGFA	vascular endothelial growth factor A	11.0	Publications
42	CCND1	cyclin D1	11.0	Publications
43	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
44	IL2	interleukin 2	11.0	Publications
45	BCL2	B-cell CLL/lymphoma 2	11.0	Publications
46	DCAF8L1	DDB1 and CUL4 associated factor 8-like 1	11.0	Orthologs
47	FEV	FEV (ETS oncogene family)	11.0	Publications
48	EEF1A2	eukaryotic translation elongation factor 1 alpha 2	11.0	Publications
49	ZNF347	zinc finger protein 347	11.0	Disorders
50	CD5	CD5 molecule	11.0	Publications

Pathways related to plasmacytoma according to GeneDecks:

(show top 50)    (show all 84)

id	Pathway	Score	Top Affiliating Genes
1	Primary immunodeficiency20	10.7	CIITA, BTK
2	Immune response Oncostatin M signaling via JAK-Stat in human cells10	10.5	OSM, CCND1, LIFR
3	Immune response_Oncostatin M signaling via JAK-Stat in human cells41	10.3	OSM, CCND1, IL6ST, LIFR, VEGFA
4	Development_Thrombopoetin signaling via JAK-STAT pathway41	10.2	OSM, CDKN1A, BCL2L1
5	PI3K Signaling in B-Lymphocyte36	10.1	BTK, CD79A, CD79B, PTPRC
6	Transcription_Androgen Receptor nuclear signaling41	10.1	HRAS, CCND1, IL6ST, IL6R, IL6, CDKN1A
7	Transcription Androgen Receptor nuclear signaling10	10.1	HRAS, CCND1, IL6ST, IL6R, IL6, CDKN1A
8	RAR-Gamma-RXR-Alpha Degradation36	10.1	OSM, CCL3, IL2, IL11, LIF, BTK
9	Immune response BCR pathway10	10.1	PTPRC, HRAS, IGKC, IGH@, CD79B, CD79A
10	Immune response_BCR pathway41	10.1	PTPRC, HRAS, IGKC, IGH@, CD79B, CD79A
11	Bladder cancer20	10.0	HRAS, CCND1, CDKN1A, MYC, VEGFA
12	Small cell lung cancer20	10.0	CCND1, CDKN2B, BCL2L1, BCL2, MYC
13	Development Thrombopoetin signaling via JAK-STAT pathway10	10.0	OSM, CCND1, CDKN1A, BCL2L1
14	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.9	CCL3, IL2RB, IL2, BCL2
15	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.9	CXCR5, IL6ST, IL6R, IL6, IL4
16	Immune System38	9.8	IRF8, IL6R, IL6ST, IFI27, IRF4, CD40
17	Lymphocyte Signaling3	9.8	PRDM1, BTK, PAX5, SPI1, AICDA, IL2RB
18	Acute myeloid leukemia20	9.7	SPI1, HRAS, CCND1, MTOR, MYC
19	Intestinal immune network for IgA production20	9.7	AICDA, IL6, IL4, IL2, ITGA4, CD40
20	Signal transduction_AKT signaling41	9.6	CCND1, CDKN1A, MTOR, BCL2L1, MYC
21	Immune response IL-22 signaling pathway10	9.5	IL2RB, IL2, BCL2L1, BCL2, MYC
22	JNK Pathway36	9.5	HRAS, CCL3, IL6R, IL6, IL2RB, IL2
23	IL-6 Pathway36	9.4	OSM, HRAS, CCL3, IL6ST, IL6R, IL4
24	Hematopoietic cell lineage20	9.4	IL6R, IL6, IL4, IL11, ITGA4, CD5
25	PGC1Alpha Pathway36	9.4	BTK, BCL2, IL11, IL2, IL2RB, IL4
26	NFAT Signaling and Lymphocyte Interactions36	9.3	CCL3, IL4, IL2RB, IL2, IL11, BCL2
27	Pancreatic Adenocarcinoma36	9.3	CCND1, IL6, IL2, CDKN2B, CDKN1A, BCL2L1
28	MIF Mediated Glucocorticoid Regulation36	9.3	OSM, CCL3, IL6, IL4, IL2, IL11
29	MIF Regulation of Innate Immune Cells36	9.3	OSM, CCL3, BTK, LIF, BCL2, IL11
30	Jak-STAT signaling pathway20	9.3	OSM, CCND1, IL6ST, IL6R, IL4, IL2RB
31	all-trans-Retinoic Acid Signaling in Brain36	9.2	OSM, CCL3, IL6, IL4, IL2, IL11
32	SOCS Pathway36	9.2	CCL3, IL6, IL4, IL2, IL11, BCL2
33	Endothelin-1 Signaling Pathway36	9.2	OSM, HRAS, CCL3, IL6, IL4, IL2
34	Regulation of eIF4 and p70S6K36	9.1	HRAS, CCL3, IL6, IL4, IL2, IL11
35	Glucocorticoid Receptor Signaling36	9.1	IL4, IL6, IL6R, CCL3, IL2RB, IL2
36	TGF-Beta Pathway36	9.1	HRAS, CCL3, IL6R, IL6, IL4, IL2RB
37	PAK Pathway36	9.0	OSM, HRAS, CCL3, IL6, IL4, IL2
38	PEDF Induced Signaling36	9.0	OSM, HRAS, CCL3, IL6, IL4, IL2
39	MAPK Family Pathway36	9.0	IL6, IL6R, CCL3, HRAS, IL4, IL2RB
40	ERK Signaling36	9.0	OSM, HRAS, CCL3, IL6, IL4, IL2
41	Akt Signaling36	8.9	IL6R, CCND1, CCL3, TNFRSF8, OSM, IL6
42	Tec Kinases Signaling36	8.9	IL4, IL6, IL6R, CCL3, TNFRSF8, IL2RB
43	Rho Family GTPases36	8.9	OSM, STMN1, CCL3, IL6, IL4, IL2
44	Molecular Mechanisms of Cancer36	8.9	IL6, IL6R, CCND1, HRAS, TNFRSF8, NOTCH4
45	JAK-STAT Pathway36	8.9	IL4, IL6, IL6R, CCL3, HRAS, IL2RB
46	Cytokine-cytokine receptor interaction20	8.8	OSM, TNFRSF8, CCL3, IL6ST, IL6R, IL6
47	Antioxidant Action of Vitamin-C36	8.8	IL6, IL6R, CCL3, HRAS, TNFRSF8, OSM
48	p38 Signaling36	8.8	IL6, IL6R, CCL3, HRAS, TNFRSF8, OSM
49	Pathways in cancer20	8.6	NOS2, SPI1, CCND1, CDKN2B, CDKN1A, MTOR
50	STAT3 Pathway36	8.5	IL2RB, IL2, IL11, CDKN1A, BCL2, LIFR

Compounds related to plasmacytoma according to GeneDecks:

(show top 50)    (show all 202)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.7	ITGA4, BCL6
2	threonine32	10.5	BTK, STMN1, IL2RB, CDKN2B
3	hyaluronic acid32 18	11.1	OSM, IL11, B2M, MUC1, MYC
4	n acetylcysteine32	10.1	PTPRC, IFI27, CD79A, CDKN1A, CD40, IL2RB
5	pge232	10.0	OSM, LIF, CIITA, FST, CCL3, HP
6	ivig32	10.0	AICDA, BTK
7	gp 13032	9.8	LIFR, IL6ST, HP, HRAS, IL6R, OSM
8	12-o-tetradecanoylphorbol 13-acetate32	9.8	CD34, IL2RB, IL6R, STMN1, CDKN1A, BCL6
9	calcitriol32 42 9 18 9	13.7	IL2, MYC, LIF, PAX5, B2M, CDKN1A
10	doxorubicin32 34 9 9	12.5	BCL2L1, HRAS, STMN1, IFI27, CCND1, IL11
11	sb 20358032 42	10.5	BCL2L1, IL6, LIF, CCND1, CDKN1A, BTK
12	progesterone32 42 9 18 9	13.4	STMN1, LIF, LIFR, BCL2, FST, CDKN1A
13	acth32	9.4	LIFR, PTPRC, HP, IL6ST, IL6, IL11
14	prednisolone32 9 9	11.3	IL6R, CCL3, IL2, CD40, IL6ST, MYC
15	paclitaxel32 34 9 9	12.2	LIF, VEGFA, MYC, LIFR, BCL2, BCL2L1
16	gm-csf32	9.2	VEGFA, IL11, CCL3, IL6, IL4, IL2
17	il 1032	9.2	CCL3, IL2RB, LIF, CD40, IL6R, IL2
18	rituximab32 34 9 9	12.2	BCL2L1, BCL6, MTOR, B2M, CD79A, CD40
19	tgf beta132	9.1	FST, OSM, CCND1, IL6, IL11, CDKN1A
20	neopterin32	9.0	CD79A, CD40, IL2RB, B2M, IL6, IL6R
21	ribonucleic acid32	9.0	IL11, IL6ST, IL6R, MYC, BLZF1, MUC1
22	agarose32	9.0	LIF, MYC, IL6R, PTPRC, CDKN1A, MUC1
23	rantes32	8.9	CD40, CCL3, IL6R, IL6, IL4, IL2RB
24	cytarabine32 34 9 9	11.9	BCL2L1, IL11, IFI27, BCL2, LIF, MYC
25	gemcitabine32 34 9 9	11.9	MYC, BCL2, BCL2L1, MUC1, CCND1, CDKN1A
26	pd 98,05932	8.7	MYC, LIF, BCL2, BCL2L1, MTOR, CDKN1A
27	oligonucleotide32	8.7	CD40, IRF8, IL11, IL6R, CCND1, IGH@
28	estrogen32	8.7	IL6ST, IFI27, HRAS, HP, NOS2, STMN1
29	butyrate32	8.6	CDKN1A, BCL2L1, MUC1, B2M, IL11, IFI27
30	wortmannin32 42	9.5	CCND1, BCL2, CCL3, ITGA4, CD40, CDKN1A
31	ly29400232	8.5	IL4, HRAS, VEGFA, IL6, CCND1, CCL3
32	15-deoxy-delta-12,14-prostaglandin j232	8.5	IL4, CDKN1A, BCL2L1, MYC, VEGFA, NOS2
33	histamine32 18	9.5	MPO, BTK, IL6, OSM, PTPRC, CCL3
34	tacrolimus32 34 9 9	11.5	MTOR, CD79A, MYC, IL4, IL2RB, IL11
35	phosphatidylinositol32	8.4	PTPRC, ITGA4, IL2RB, IL6R, IL6ST, CCND1
36	steroid32	8.2	IL11, OSM, HP, HRAS, BLZF1, POU2F2
37	cisplatin32 34 9 9	11.0	LIF, MPO, MTOR, MYC, VEGFA, BLZF1
38	cyclosporin a32 42	8.9	MYC, LIF, BLZF1, CIITA, STMN1, TNFRSF8
39	calcium32 9 18 9	10.7	BLZF1, CCL3, IL6ST, IL6R, IL11, BTK
40	indomethacin32 9 9	9.7	MYC, B2M, MPO, CD79A, CD40, IL11
41	thymidine32 18	8.7	MYC, LIF, CIITA, MUC1, B2M, FST
42	vegf32	7.3	CD40, IL11, IL6R, IL6ST, CCL3, IFI27
43	genistein32 9 18 9	10.3	OSM, NOS2, CD40, ITGA4, IL2, IL2RB
44	paraffin32	7.3	VEGFA, MYC, CD40, IL4, CCND1, IFI27
45	actinomycin d32	7.1	CD40, IL6, CCL3, HP, NOS2, IL4
46	cycloheximide32	6.7	ITGA4, IL6R, IL6ST, CCND1, CCL3, AICDA
47	retinoic acid32 42 18	8.5	MYC, LIF, BLZF1, BCL2, BCL2L1, BCL6
48	dexamethasone32 42 34 9 9	10.2	CD79A, CD40, ITGA4, IL11, IL2, IL2RB
49	serine32	5.7	CIITA, IL2, IL2RB, IL6ST, CCND1, CCL3
50	tyrosine32	5.3	PTPRC, IL6, IL4, IL2RB, IL2, IL11

Cellular components related to plasmacytoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-6 receptor complex	GO:005896	10.2	IL6ST, IL6R, IL6
2	integral to plasma membrane	GO:005887	8.8	NOTCH4, PTPRC, MAEA, IL2RB, CD40, CD5
3	external side of plasma membrane	GO:009897	8.7	B2M, PTPRC, IL6ST, IL4, IL2RB, ITGA4
4	extracellular space	GO:005615	7.6	IL6, IL6R, IL6ST, CCL3, HP, OSM
5	extracellular region	GO:005576	7.6	NOTCH4, HP, IGKC, CCL3, IL6ST, IL6R

Biological processes related to plasmacytoma according to GeneDecks:

(show all 40)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of collagen biosynthetic process	GO:032966	10.6	IL6R, IL6, CIITA
2	positive regulation of acute inflammatory response	GO:002675	10.6	OSM, IL6ST, IL6
3	interleukin-6-mediated signaling pathway	GO:070102	10.6	IL6, IL6R, IL6ST
4	leukemia inhibitory factor signaling pathway	GO:048861	10.6	IL6ST, LIFR, LIF
5	ciliary neurotrophic factor-mediated signaling pathway	GO:070120	10.6	LIFR, IL6R, IL6ST
6	positive regulation of B cell differentiation	GO:045579	10.5	BTK, CD27, PRDM1
7	positive regulation of tyrosine phosphorylation of Stat1 protein	GO:042511	10.5	IL6ST, CD40, LIF
8	positive regulation of tyrosine phosphorylation of Stat3 protein	GO:042517	10.5	IL6ST, IL6R, IL6, LIF
9	negative regulation of hormone secretion	GO:046888	10.5	OSM, IL11, LIF
10	positive regulation of cellular component movement	GO:051272	10.4	STMN1, BCL6, VEGFA
11	B cell proliferation	GO:042100	10.3	PTPRC, CD40, CD79A, BCL2
12	humoral immune response	GO:006959	10.3	PAX5, BCL2, IL6, POU2F2
13	B cell receptor signaling pathway	GO:050853	10.3	PTPRC, CD79B, CD79A, BCL2, BTK
14	positive regulation of peptidyl-serine phosphorylation	GO:033138	10.3	OSM, IL6, IL11, BCL2, LIF, VEGFA
15	positive regulation of anti-apoptosis	GO:045768	10.3	IL6ST, IL6R, IL6, CDKN1A, BCL2L1, LIFR
16	positive regulation of MAPK cascade	GO:043410	10.3	OSM, PTPRC, HRAS, IL6R, IL6, IL11
17	monocyte chemotaxis	GO:002548	10.2	CCL3, IL6R, IL6
18	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.2	TNFRSF8, IL6R, IL6, CD40, BTK
19	induction of apoptosis by intracellular signals	GO:008629	10.1	HRAS, CDKN1A, BCL2L1, BCL2, MYC
20	hepatic immune response	GO:002384	10.0	IL6, IL6R
21	cytokine-mediated signaling pathway	GO:019221	10.0	IFI27, IL6ST, IL6R, IL6, IL2RB, IRF8
22	organ regeneration	GO:031100	10.0	LIF, LIFR, CDKN1A, CCND1
23	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.0	OSM, IL6R, IL6, IL11, MTOR, LIF
24	negative regulation of cell proliferation	GO:008285	9.9	OSM, TNFRSF8, HRAS, IL6, CDKN2B, CDKN1A
25	positive regulation of isotype switching to IgG isotypes	GO:048304	9.9	PTPRC, IL4, IL2, CD40
26	positive regulation of T cell proliferation	GO:042102	9.8	PTPRC, IL6ST, IL6, IL4
27	positive regulation of protein phosphorylation	GO:001934	9.8	HRAS, CCND1, CD40, MTOR, VEGFA
28	B cell differentiation	GO:030183	9.7	PTPRC, AICDA, IL4, IL11, ITGA4, CD79A
29	response to cytokine stimulus	GO:034097	9.7	IL6ST, IL6R, IL4, BCL2L1, BCL2, LIFR
30	positive regulation of cell proliferation	GO:008284	9.7	OSM, HRAS, IL6ST, IL6R, IL6, IL2
31	regulation of immune response	GO:050776	9.6	IGKC, IL4, ITGA4, CD40, CD34, B2M
32	positive regulation of B cell proliferation	GO:030890	9.5	BCL2, PTPRC, IL4, IL2, CD40, CDKN1A
33	immune response	GO:006955	9.4	OSM, IGKC, IL4, IL2, IRF8, CD79B
34	defense response to Gram-negative bacterium	GO:050829	9.4	NOS2, IL6R, IL6
35	anti-apoptosis	GO:006916	9.4	EEF1A2, IL2, CD27, MPO, MUC1, BCL2L1
36	negative regulation of apoptotic process	GO:043066	9.2	IL6, IL4, CDKN1A, BCL2L1, BCL2, MYC
37	response to drug	GO:042493	9.2	CCND1, IL4, CDKN1A, B2M, XBP1, BCL2
38	positive regulation of transcription, DNA-dependent	GO:045893	9.0	EBF1, POU2F2, NOTCH4, SPI1, IL6, IL4
39	negative regulation of gene expression	GO:010629	8.9	CDKN1A, CD34, CCL3, NOS2
40	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.8	IL2, IL4, IL6, HRAS, SPI1, OSM

Molecular functions related to plasmacytoma according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	ciliary neurotrophic factor receptor activity	GO:004897	10.4	LIFR, IL6R, IL6ST
2	interleukin-6 receptor binding	GO:005138	10.4	IL6ST, IL6R, IL6
3	interleukin-6 binding	GO:019981	10.3	IL6R, IL6ST
4	interleukin-6 receptor activity	GO:004915	10.2	IL6R, IL6ST
5	leukemia inhibitory factor receptor activity	GO:004923	10.0	LIFR, IL6ST
6	transmembrane signaling receptor activity	GO:004888	10.0	TNFRSF8, CD5, CD79B, CD27, CD79A
7	cytokine activity	GO:005125	9.4	OSM, IL6, IL4, IL2, IL11, LIF
8	growth factor activity	GO:008083	9.4	OSM, IL6, IL4, IL2, IL11, LIF
9	protein binding	GO:005515	5.4	CD40, ITGA4, IL4, IL6R, IL6ST, CCND1