MCID: PLS011
MIFTS: 63

Plasmacytoma malady

Cancer diseases, Neuronal diseases, Blood diseases categories

Summaries for Plasmacytoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Plasmacytoma refers to a malignant plasma cell tumor growing within soft tissue or within the axial... more...

MalaCards: Plasmacytoma, also known as solitary plasmacytoma, is related to myeloma and multiple myeloma. An important gene associated with Plasmacytoma is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Th17 Differentiation. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and thyroid, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Classifications for Plasmacytoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

48
plasmacytoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

plasmacytoma 8 10 44 48 60
solitary plasmacytoma 8 48
myeloma - solitary 8
myeloma, solitary 8
solitary myeloma 8


External Ids:

Disease Ontology8 DOID:3721
MeSH34 D010954
NCIt39 C9349, C6932
MESH via Orphanet35 D010954
ICD10 via Orphanet26 C90.2
SNOMED-CT via Orphanet57 10639003, 415112005
UMLS via Orphanet61 C0032131
ICD1025 C90.3

Related Diseases for Plasmacytoma

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17GeneCards, 18GeneDecks
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Diseases related to Plasmacytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma31.2IFI27, IL6ST, IL6, IL11, OSM, B2M
2multiple myeloma31.1B2M, IL6
3amyloidosis30.4IGKC, B2M
4leukemia30.4IFI27, OSM, STMN1, B2M, PRDM1, LIF
5pancreatitis30.4IL6, IL11
6sarcoma30.1STMN1, OSM
7peritonitis29.9IL6, LIF, B2M
8sarcoidosis29.9CD27, IL2RB
9myeloid leukemia29.9LIF, IL11, IL6ST
10pituitary adenoma29.9IFI27, LIF, FST
11burkitt's lymphoma29.9IFI27, MPP1, AICDA, CD27, CXCR5
12adenoma29.9FST, LIF, OSM, IFI27
13hodgkin's lymphoma29.9STMN1, MPP1, PRDM1, AICDA, POU2F2, IL2RB
14hepatitis29.7IL2RB
15hepatitis c29.7AICDA
16macroglobulinemia29.7B2M
17kaposi's sarcoma29.7IL6
18arthritis29.7OSM, B2M, LIF, IL2RB, IL6, IL6ST
19hepatocellular carcinoma29.7IFI27, STMN1, AICDA, IL6, FST
20breast cancer29.7IFI27, OSM, STMN1, LIF, IL11, IL6ST
21melanoma29.7IFI27, OSM, STMN1, MPP1, CD27, IL2RB
22myelofibrosis29.7IL11, LIF
23extramedullary plasmacytoma11.1
24thyroiditis10.5
25cervicitis10.3
26anaplastic plasmacytoma10.3
27tonsillitis10.3
28solitary osseous plasmacytoma10.3
29mediastinitis10.3
30obstructive jaundice10.2
31poems syndrome10.2
32meningioma10.2
33plasma cell neoplasm10.2
34polyneuropathy10.1
35intussusception10.0
36duodenitis10.0
37solitary plasmacytoma of chest wall10.0
38marginal zone b-cell lymphoma10.0
39extramedullary soft tissue plasmacytoma10.0
40primary plasmacytoma of the bone10.0
41frontal sinusitis10.0
42inflammatory bowel disease10.0IL6
43uveitis10.0CXCR5
44pulmonary fibrosis10.0OSM
45galactosemia10.0IL6
46acquired immunodeficiency syndrome10.0B2M, IL6
47sjogren's syndrome10.0B2M
48malt lymphoma10.0IGKC, CXCR5
49nephritis10.0LIF, B2M
50cervical intraepithelial neoplasia10.0IFI27

Graphical network of the top 20 diseases related to Plasmacytoma:



Diseases related to plasmacytoma

Clinical Features for Plasmacytoma

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Drugs & Therapeutics for Plasmacytoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Plasmacytoma

Drug clinical trials:

Search ClinicalTrials for Plasmacytoma

Search NIH Clinical Center for Plasmacytoma

Search CenterWatch for Plasmacytoma

Genetic Tests for Plasmacytoma

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Anatomical Context for Plasmacytoma

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32MalaCards
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MalaCards organs/tissues related to Plasmacytoma:

32
Bone, Bone marrow, Thyroid, Breast, Colon, Skin, Lung, Lymph node, Pancreas, B cells, Liver, Tonsil, Kidney, Tongue, Heart, Small intestine, Testis, Brain, Salivary gland, Trachea, T cells, Ovary, Pituitary, Cervix, Adrenal gland, Spinal cord, Skeletal muscle, Endothelial, Myeloid, Prostate, Nk cells

Animal Models for Plasmacytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Plasmacytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.1PRDM1, LIF, IL2RB, IL6, IL6ST, FST
2MP:00053879.9IL6ST, B2M, MPP1, PRDM1, LIF, IGKC
3MP:00053979.9AICDA, IGKC, LIF, PRDM1, B2M, POU2F2
4MP:00107719.9OSM, LIF, AICDA, IL6, IL6ST, FST
5MP:00053849.7IGKC, LIF, PRDM1, MPP1, B2M, AICDA

Publications for Plasmacytoma

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50PubMed
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Articles related to Plasmacytoma:

(show top 50)    (show all 857)
idTitleAuthorsYear
1
Anaplastic Solitary plasmacytoma of mandible, masquerading as sarcoma. (24353648)
2013
2
Phlegmasia caerulea dolens secondary to pelvic plasmacytoma and left femoral deep vein thrombosis. (23959409)
2013
3
Long-term gastric plasmacytoma follow-up after Helicobacter pylori eradication. (23498151)
2013
4
Solitary plasmacytoma: 10 years' experience at All India Institute of Medical Sciences, New Delhi. (23163525)
2013
5
Prognostic factors associated with solitary plasmacytoma. (24259986)
2013
6
Solitary extramedullary plasmacytoma presenting as an endobronchial mass. (24042522)
2013
7
Extraosseous plasmacytoma with an aggressive course occurring solely in the CNS. (23025535)
2013
8
Rib plasmacytoma and IgA multiple myeloma with hyperviscosity syndrome. (22827791)
2012
9
The role of helical tomotherapy in the treatment of bone plasmacytoma. (21705210)
2012
10
Successful Treatment of Posttransplant EBV-Associated Lymphoma and Plasmacytoma Solely Localized to the CNS. (22937330)
2012
11
Solitary extramedullary plasmacytomas of the thyroid in Hashimoto's thyroiditis. (22783809)
2012
12
Solitary plasmacytoma of the jaw. (22134311)
2011
13
Diagnosis of pancreatic plasmacytoma by endoscopic ultrasound-guided fine-needle aspiration. (21425019)
2011
14
Complete resection of a mediastinal solitary extramedullary plasmacytoma and reconstruction of right pulmonary artery and superior vena cava. (22115236)
2011
15
Perinasal dermatitis due to a local plasmacytoma with vicinal nodular ALI> amyloi. (21838450)
2011
16
Euthyroid enlargement of the thyroid gland. Plasmacytoma in thyroid. (21209471)
2010
17
Soft tissue extramedullary plasmacytoma. (20204131)
2010
18
Bronchoscopic electrocautery therapy of a solitary endobronchial extramedullary plasmacytoma. (21341121)
2010
19
Impaired vision associated with a solitary intracranial plasmacytoma. (20570518)
2010
20
Pathology quiz case 2: extramedullary plasmacytoma (EMP). (20578292)
2010
21
Solitary plasmacytoma of the spine: an unusual presentation. (19910446)
2010
22
Skeletal Plasmacytoma: progression of disease and impact of local treatment; an analysis of SEER database. (19778427)
2009
23
Blimp1 is limiting for transformation in a mouse plasmacytoma model. (19329782)
2009
24
Sensory-motor polyradiculoneuropathy as the first manifestation of sternum bone plasmacytoma only revealed by bone scintigraphy. (19070487)
2009
25
Severe episodic dyspnoea and abnormal flow-volume loop. Extramedullary plasmacytoma (EMP). (19252019)
2009
26
Post-transplant plasmacytoma without Epstein-Barr virus infection occurring rapidly after unrelated allogeneic bone marrow transplantation. (19034613)
2008
27
Treatment of BehAset's syndrome and plasmacytoma in a patient with peripheral blood stem cell transplantation. (19052990)
2008
28
Case report: Solitary plasmacytoma of bone with oncogenic osteomalacia: recurrence of tumour confirmed by PET/CT. A case report with a review of the radiological literature. (18344267)
2008
29
Extramedullary plasmacytoma involving the abdominal vessels and pancreas. (17909974)
2007
30
Radiotherapy for solitary extramedullary plasmacytoma in the head-and-neck region: A dose greater than 45 Gy to the target volume improves the local control. (16343803)
2006
31
Case of multiple myeloma associated with extramedullary cutaneous plasmacytoma and pyoderma gangrenosum. (16700800)
2006
32
An unusual presentation of a secondary extramedullary plasmacytoma in a patient with multiple myeloma. (15757045)
2005
33
A case of Crow-Fukase syndrome with extramedullary plasmacytoma: marked clinical deterioration following a biopsy to plasmacytoma]. (12884826)
2003
34
Vascular endothelial growth factor (VEGF) expression in plasmacytoma. (11908718)
2002
35
Extramedullary plasmacytoma arising from an adrenal gland. (12350502)
2002
36
Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. (10618630)
2000
37
Solitary extramedullary plasmacytoma of the nasopharynx. (11003081)
2000
38
Solitary extramedullary plasmacytoma of tonsil - a rare location. (23119699)
2000
39
Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. (10357398)
1999
40
A mechanism for selective recruitment of CD8 T cells into B7-1-transfected plasmacytoma: role of macrophage-inflammatory protein 1alpha. (9200474)
1997
41
Solitary extramedullary plasmacytoma five years after successful cardiac transplantation: case report and review of the literature. (9345329)
1997
42
Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice. (9284817)
1997
43
Extramedullary plasmacytoma of the head and neck: use of paraffin sections to assess clonality with in situ hybridization, growth fraction, and the presence of Epstein-Barr virus. (7675768)
1995
44
The plasmacytoma growth inhibitor restrictin-P is an antagonist of interleukin 6 and interleukin 11. Identification as a stroma-derived activin A. (7494003)
1995
45
Massive hematuria due to extramedullary plasmacytoma invading the bladder. (8426577)
1993
46
Solitary extramedullary plasmacytoma (a case report). (2097355)
1990
47
Extramedullary plasmacytoma of the maxillary sinus: report of a case. (3163374)
1988
48
Extramedullary plasmacytoma. (6508632)
1984
49
Extramedullary plasmacytoma. (528827)
1979
50
Extramedullary plasmacytoma of the head and neck, parotid and submandibular salivary glands. (850104)
1977

Genetic Variations for Plasmacytoma

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Expression for genes affiliated with Plasmacytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plasmacytoma

Search GEO for disease gene expression data for Plasmacytoma.

Pathways for genes affiliated with Plasmacytoma

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Sources:
53Reactome, 52R&D Systems, 12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG
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Pathways related to Plasmacytoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3IL6ST, IL6, IL2RB
2
Hide members
10.3CXCR5, IL6, IL6ST
3
Immune response Oncostatin M signaling via JAK-Stat in human cells
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10.3OSM, IL6, IL6ST
410.3IL2RB, AICDA, PRDM1, B2M
510.3OSM, LIF, IL6, IL6ST
6
Hide members
10.3IL6ST, IL6, IL11, LIF
7
Hide members
10.2OSM, LIF, IL11, IL2RB, IL6
8
Hide members
10.2IL2RB, IL11, LIF, OSM, IL6
9
Hide members
10.2IL6ST, IL6, IL2RB, B2M, IFI27
10
Hide members
10.2OSM, STMN1, LIF, IL11, IL2RB, IL6
1110.2IL6ST, IL6, IL2RB, IL11, LIF, OSM
12
Hide members
10.1OSM, LIF, CD27, CXCR5, IL11, IL6ST
13
Hide members
10.1IFI27, B2M, IGKC, CD79B, IL2RB, IL6

Compounds for genes affiliated with Plasmacytoma

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44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Plasmacytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.9IL2RB
2estrogen4410.9AICDA
3polyacrylonitrile4410.7B2M, LIF, IL2RB
4il 114410.7OSM, IL6, IL11, LIF
5filgrastim44 1111.7LIF, OSM, IL11, IL6
6endotoxin4410.7OSM, LIF, IL11
7cuprophan4410.7IL2RB, B2M, LIF
8creatinine4410.7FST, STMN1, IL2RB
9gm-csf44 2811.7LIF, IL11
10okt34410.7STMN1, IL2RB, IL6
11ifn-alpha4410.6IL6, IL6ST, IL2RB, OSM, LIF
12gp 1304410.6IL6ST, IL6, IL11, LIF, OSM
13azathioprine44 49 2 1113.6IL11, LIF, IL2RB, OSM
14tgf beta14410.6LIF, OSM, IL6, IL11, FST
151,25 dihydroxy vitamin d34410.6IL11, IL2RB, LIF, OSM
16calcitriol44 59 11 2413.6IL11, LIF, IFI27, B2M, IL6, CXCR5
17prostaglandin4410.6IL11, FST, OSM, IL6, LIF
18rantes4410.6LIF, IL6, IL2RB, IL11, CXCR5, OSM
192,5-oligoadenylate4410.6IL6, B2M, IL2RB
20cyclosporin a44 28 5912.6LIF, IL6, B2M, STMN1, IL11, IL2RB
21estradiol44 11 2412.6OSM, FST
22lactate4410.5IFI27, B2M, LIF, FST, IL6, IL2RB
23acth4410.5OSM, LIF, FST, IL2RB, IL6, IL6ST
24ribonucleic acid4410.5LIF, IL6ST, IL2RB, IL11, FST
25dexamethasone44 49 28 1113.5FST, IL6ST, OSM, IFI27, LIF, IL6
26vitamin d4410.5B2M, IL6ST, IL6, IL11, IFI27
27hyaluronic acid44 2411.5B2M, IL11, IL6, OSM
28pd 98,0594410.5IL6, LIF, IFI27, OSM, STMN1
29glucose4410.5IL11, LIF, FST, MPP1
30genistein44 28 59 2 11 2415.5IL2RB, LIF, B2M, OSM, FST, IFI27
31serine4410.5IL6ST, POU2F2, CD79B, IL2RB, OSM, STMN1
32thymidine44 2411.5OSM, STMN1, B2M, LIF, IL11, IL2RB
33progesterone44 59 28 11 2414.5FST, STMN1, IFI27, LIF, IL11, IL2RB
34phosphatidylinositol4410.4OSM, IFI27, IL11, CD79B, LIF, IL2RB
35etanercept44 49 1112.4IL2RB, IL11, IL6
36steroid4410.4POU2F2, LIF, IL11, IL2RB, FST, B2M
37cholesterol44 28 11 2413.4B2M, IL6, IL6ST, IL2RB, LIF, OSM
38vegf4410.4B2M, LIF, FST, IFI27, OSM, IL2RB
39threonine4410.4IL6ST, IL2RB, IL11, CD79B, STMN1, OSM
40txb24410.4B2M, LIF, IL11
41cysteine4410.4IL11, CD27, OSM, IGKC, LIF, B2M
42cdp5714410.4IL11, IL6
43forskolin44 49 1112.3LIF, FST, IL11, STMN1, OSM
44retinoic acid44 2411.3FST, IFI27, OSM, STMN1, B2M, LIF
45methylcellulose4410.3IL6, IL11, LIF
46oligonucleotide4410.3POU2F2, IFI27, IL11, STMN1, LIF, IL6ST
47calcium44 49 11 2413.3IFI27, IL6ST, FST, CD79B, CD27, LIF
48tyrosine4410.3IL6, IL6ST, FST, IL2RB, IL11, CD79B
49il 104410.2IL6, IL2RB, LIF
50infliximab44 49 1112.0IL2RB, IL11, IL6

GO Terms for genes affiliated with Plasmacytoma

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16Gene Ontology
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Cellular components related to Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oncostatin-M receptor complexGO:00590010.3OSM, IL6ST
2interleukin-6 receptor complexGO:00589610.3IL6, IL6ST
3external side of plasma membraneGO:00989710.3IL6ST, IL6, IL2RB, CD79B, CD27, B2M
4extracellular regionGO:00557610.1IGKC, CD27, IL11, IL6, IL6ST, FST
5extracellular spaceGO:0056159.9OSM, B2M, LIF, IL11, IL6, IL6ST

Biological processes related to Plasmacytoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of acute inflammatory responseGO:00267510.6OSM, IL6, IL6ST
2negative regulation of hormone secretionGO:04688810.6IL6, IL11, LIF, OSM
3positive regulation of peptidyl-serine phosphorylationGO:03313810.6IL6, IL11, LIF, OSM
4positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.5LIF, IL6, IL6ST
5positive regulation of MAPK cascadeGO:04341010.5OSM, LIF, IL11, IL6
6leukemia inhibitory factor signaling pathwayGO:04886110.5LIF, IL6ST
7positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5IL6, IL11, LIF, OSM
8tyrosine phosphorylation of Stat3 proteinGO:04250310.5LIF, OSM
9cytokine-mediated signaling pathwayGO:01922110.5IFI27, B2M, IL2RB, IL6, IL6ST
10negative regulation of meiosisGO:04583510.4LIF, OSM
11immune responseGO:00695510.4CXCR5, CD79B, IGKC, LIF, OSM
12interleukin-6-mediated signaling pathwayGO:07010210.4IL6ST, IL6
13positive regulation of B cell differentiationGO:04557910.4CD27, PRDM1
14positive regulation of cell proliferationGO:00828410.3OSM, LIF, IL11, IL6, IL6ST
15positive regulation of astrocyte differentiationGO:04871110.3LIF, IL6ST
16positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.1LIF, IL6ST

Molecular functions related to Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor bindingGO:00513810.4IL6ST, IL6
2growth factor activityGO:00808310.2IL6, IL11, LIF, OSM
3cytokine activityGO:00512510.0OSM, LIF, IL11, IL6

Products for genes affiliated with Plasmacytoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Plasmacytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet