MCID: PLS011
MIFTS: 49

Plasmacytoma malady

Cancer diseases, Neuronal diseases, Blood diseases, Rare diseases categories

Aliases & Classifications for Plasmacytoma

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Sources:
60UMLS, 9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 33MeSH, 55SNOMED-CT, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Plasmacytoma, Aliases & Descriptions:

Name: Plasmacytoma 9 11 43 47 60
Solitary Plasmacytoma 9 47
Solitary Osseous Plasmacytoma 60
Plasmacytoma - Category 60
 
Myeloma - Solitary 9
Myeloma, Solitary 9
Solitary Myeloma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

47
plasmacytoma:
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly


External Ids:

Disease Ontology9 DOID:3721
MeSH33 D010954
NCIt38 C6932, C9349
Orphanet47 86855
MESH via Orphanet34 D010954
ICD10 via Orphanet26 C90.2
UMLS via Orphanet61 C0032131
ICD1025 C90.3

Summaries for Plasmacytoma

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Wikipedia:63 Plasmacytoma refers to a malignant plasma cell tumor growing within soft tissue or within the axial... more...

MalaCards based summary: Plasmacytoma, also known as solitary plasmacytoma, is related to multiple myeloma and myeloma. An important gene associated with Plasmacytoma is B2M (beta-2-microglobulin), and among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Cytokine production by Th17 cells in CF. The compounds pamidronate and pmma have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and thyroid, and related mouse phenotypes are tumorigenesis and normal.

Related Diseases for Plasmacytoma

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Graphical network of the top 20 diseases related to Plasmacytoma:



Diseases related to plasmacytoma

Symptoms for Plasmacytoma

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Drugs & Therapeutics for Plasmacytoma

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Drug clinical trials:

Search ClinicalTrials for Plasmacytoma

Search NIH Clinical Center for Plasmacytoma

Genetic Tests for Plasmacytoma

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Anatomical Context for Plasmacytoma

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MalaCards organs/tissues related to Plasmacytoma:

31
Bone, Bone marrow, Thyroid, Breast, Colon, Pancreas, Skin, Lymph node, Lung, B cells, Liver, Tonsil, Tongue, Heart, Small intestine, Kidney, Testis, Brain, Salivary gland, Adrenal gland, Ovary, Cervix, T cells, Trachea, Pituitary, Spinal cord, Skeletal muscle, Myeloid, Endothelial, Spleen, Prostate, Nk cells

Animal Models for Plasmacytoma or affiliated genes

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MGI Mouse Phenotypes related to Plasmacytoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3IL6, IRF4, B2M, AICDA
2MP:00028738.1CD79B, STMN1, PRDM1, AICDA
3MP:00053847.7AICDA, B2M, PRDM1, IL6, CD27
4MP:00053977.1CD27, AICDA, B2M, IRF4, PRDM1, IL6
5MP:00053877.0AICDA, B2M, IRF4, PRDM1, IL6, CD79B

Publications for Plasmacytoma

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Articles related to Plasmacytoma:

(show top 50)    (show all 909)
idTitleAuthorsYear
1
Recurrent extramedullary plasmacytoma in asymptomatic multiple myeloma: a case report. (25880694)
2015
2
Expect the Unexpected: Report of a Case of Pediatric Pharyngeal Extraosseous Plasmacytoma with Tumefactive Amyloidosis ("Amyloidoma") and a Review of the Literature. (25672253)
2015
3
Gradenigo's syndrome as first presentation of solitary osseous plasmacytoma of the petrous apex. (24979569)
2014
4
Extramedullary plasmacytoma in the lung of a Doberman pinscher dog. (24381343)
2014
5
Solitary plasmacytoma of the mandible - a rare entity. (24155610)
2013
6
Multiple myeloma presenting as plasmacytoma of the jaws showing prominent bone formation during chemotherapy. (23520399)
2013
7
A variant of AESOP syndrome (adenopathy and extensive skin patch overlying a plasmacytoma)--reply. (24048432)
2013
8
Primary plasmacytoma of the kidney. (23936722)
2013
9
Plasmacytoma associated with canaliculitis. (21743365)
2012
10
Rib plasmacytoma and IgA multiple myeloma with hyperviscosity syndrome. (22827791)
2012
11
The role of helical tomotherapy in the treatment of bone plasmacytoma. (21705210)
2012
12
Plasmacytoma-like posttransplant lymphoproliferative disorder following orthotopic liver transplantation: a case report. (21911168)
2011
13
Anal canal plasmacytoma-An uncommon presentation site. (24376953)
2010
14
Images in clinical medicine. Plasmacytoma of the skull. (21105787)
2010
15
A rare case of primary gastric plasmacytoma: an unforeseen surprise. (21358099)
2010
16
Dacryocystitis provoked by recurrence of extramedullary plasmacytoma of the orbit: a case report. (20437877)
2010
17
Skeletal Plasmacytoma: progression of disease and impact of local treatment; an analysis of SEER database. (19778427)
2009
18
Radiotherapy for extramedullary plasmacytoma of the head and neck. (18707826)
2009
19
Port site and local recurrence of incidental solitary renal plasmacytoma after retroperitoneoscopic radical nephrectomy. (18336883)
2009
20
Synchronous oral squamous cell carcinoma and extramedullary plasmacytoma of the tonsil. (19570691)
2009
21
Successful treatment of extramedullary gastric plasmacytoma with the combination of bortezomib and dexamethasone: first reported case. (17560647)
2008
22
Incidental detection of concurrent extramedullary plasmacytoma and amyloidoma of the nasopharynx on [18F]fluorodeoxyglucose positron emission tomography/computed tomography. (19001338)
2008
23
Extramedullary plasmacytoma in the maxillary sinus. (19037537)
2008
24
Laryngeal plasmacytoma presenting as amyloid tumour: a case report. (17431662)
2007
25
Amyloid-depositing plasmacytoma of cervical spine masquerades as a granulomatous inflammatory reaction. (17206313)
2007
26
Cutaneous plasmacytoma in three golden hamsters (Mesocrietus auratus). (16466459)
2006
27
Multifocal extramedullary plasmacytoma with paraproteinemia, pleural involvement and retroperitoneal lymphadenopathy: an uncommon pattern of relapse of solitary osseous plasmacytoma. (16496148)
2006
28
Extramedullary plasmacytoma of the salivary gland in two Syrian hamsters (Mesocricetus auratus). (16301579)
2005
29
Insights into extramedullary tumour cell growth revealed by expression profiling of human plasmacytomas and multiple myeloma. (12930383)
2003
30
Unilateral exophthalmos caused by an extramedullary plasmacytoma: a case report. (23365508)
2003
31
Solitary extramedullary plasmacytoma of the premaxilla. (12780455)
2003
32
A case of retroperitoneal extramedullary plasmacytoma with multiple metastases. (11368939)
2000
33
Murine plasmacytomas, carrier of the t(12;15) chromosomal translocation, develop from immature/mature B cells not from differentiated plasma cells. (10223178)
1999
34
Primary gastric plasmacytoma: a rare cause of hypertrophic gastritis in an adolescent. (10512402)
1999
35
Extramedullary plasmacytoma of the head and neck associated with the human immunodeficiency virus. (9473836)
1998
36
Cleaved variant of plasmacytoma with myelomonocytic differentiation--immunohistochemical and ultrastructural studies. (9364303)
1997
37
Fine-needle aspiration of pancreatic extramedullary plasmacytoma: possible confusion with islet cell tumor. (7924813)
1994
38
Extramedullary plasmacytoma of the heart presenting as cardiac emergency. Review of literature. (8092116)
1994
39
Extramedullary plasmacytoma of the head and neck. (7850655)
1994
40
Primary cutaneous extramedullary plasmacytoma secreting lambda IgG. (8403475)
1993
41
A rare case of extramedullary plasmacytoma in the mediastinum. (1300172)
1992
42
Solitary conjunctival extramedullary plasmacytoma. (2350120)
1990
43
Extramedullary plasmacytoma of the testicle. Sonographic appearance and ultrasonically guided biopsy. (2198076)
1990
44
Anaplastic solitary extramedullary plasmacytoma of the cecum. Report of a case confirmed by immunoperoxidase staining. (3315510)
1987
45
Extramedullary plasmacytoma of the bladder: a case report and review of literature. (7083118)
1982
46
Extramedullary plasmacytoma of the head and neck. (6792654)
1981
47
Extramedullary plasmacytoma of the parotid gland. (7359969)
1980
48
Mediastinal extramedullary plasmacytoma. (7375991)
1980
49
Extramedullary plasmacytoma of the gastrointestinal tract in a renal transplant recipient. (380262)
1979
50
Extramedullary plasmacytoma of the head and neck. (5659409)
1968

Variations for Plasmacytoma

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Expression for genes affiliated with Plasmacytoma

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Search GEO for disease gene expression data for Plasmacytoma.

Pathways for genes affiliated with Plasmacytoma

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Pathways related to Plasmacytoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6PRDM1, IL6
2
Show member pathways
9.6IL6, IRF4
3
Show member pathways
9.2B2M, IRF4, IL6
4
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.2IRF4, IL6, CD79B
59.1IRF4, AICDA
6
Show member pathways
9.1CD79B, IL6, STMN1
7
Show member pathways
8.9IL6, B2M, AICDA
88.8PRDM1, B2M, AICDA

Compounds for genes affiliated with Plasmacytoma

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Compounds related to Plasmacytoma according to GeneCards Suite gene sharing:

(show all 17)
idCompoundScoreTop Affiliating Genes
1pamidronate43 49 1212.1IL6, B2M
2pmma4310.0B2M, IL6
32,5-oligoadenylate4310.0IL6, B2M
4neopterin439.9IL6, B2M
5rituximab43 49 1211.8IL6, B2M
6okt3439.7STMN1, IL6
7pge1439.7IL6, B2M
8dcmp43 2410.6B2M, AICDA
9ivig439.5IL6, AICDA
10thalidomide43 49 59 1212.5IL6, B2M
11cyclosporin a43 28 5911.4B2M, STMN1, IL6
12cytidine43 24 1211.4PRDM1, AICDA
13thymidine43 2410.3B2M, STMN1, IL6
14creatinine439.3IL6, STMN1, B2M
15cycloheximide438.9AICDA, B2M, IL6
16serine438.6CD27, CD79B, STMN1, B2M
17estrogen438.6IL6, STMN1, B2M, AICDA

GO Terms for genes affiliated with Plasmacytoma

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Cellular components related to Plasmacytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9CD27, CD79B, IL6, B2M

Biological processes related to Plasmacytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1T-helper 17 cell lineage commitmentGO:00725409.7IL6, IRF4
2interferon-gamma-mediated signaling pathwayGO:00603339.6IRF4, B2M
3defense response to protozoanGO:00428329.6IL6, IRF4
4positive regulation of B cell differentiationGO:00455799.6CD27, PRDM1
5negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.3CD27, IL6
6cytokine-mediated signaling pathwayGO:00192219.1B2M, IRF4, IL6

Molecular functions related to Plasmacytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00048889.6CD27, CD79B
2protein bindingGO:00055157.1CD27, IL6, PRDM1, IRF4, B2M, AICDA

Products for genes affiliated with Plasmacytoma

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  • Kits and Assays

Sources for Plasmacytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet