PAI-1D
MCID: PLS029
MIFTS: 44

Plasminogen Activator Inhibitor-1 Deficiency (PAI-1D) malady

Categories: Genetic diseases, Rare diseases, Blood diseases

Aliases & Classifications for Plasminogen Activator Inhibitor-1 Deficiency

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Aliases & Descriptions for Plasminogen Activator Inhibitor-1 Deficiency:

Name: Plasminogen Activator Inhibitor-1 Deficiency 52 24 70 12 68
Plasminogen Activator Inhibitor Type 1 Deficiency 48 27
Congenital Plasminogen Activator Inhibitor Type 1 Deficiency 54
Hyperfibrinolysis Due to Pai1 Deficiency 24
 
Plasminogen Activator Inhibitor, Type I 12
Congenital Pai-1 Deficiency 54
Pai-1d 70

Characteristics:

Orphanet epidemiological data:

54
congenital plasminogen activator inhibitor type 1 deficiency:
Inheritance: Autosomal recessive; Age of onset: Adolescent,Adult,Childhood,Infancy; Age of death: any age

HPO:

64
plasminogen activator inhibitor-1 deficiency:
Inheritance: autosomal dominant inheritance, autosomal recessive inheritance
Onset and clinical course: congenital onset

Classifications:



External Ids:

OMIM52 613329
Orphanet54 ORPHA465
ICD10 via Orphanet31 D68.8
MedGen37 C2750067
MeSH39 D025861

Summaries for Plasminogen Activator Inhibitor-1 Deficiency

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NIH Rare Diseases:48 Plasminogen activator inhibitor type 1 (pai-1) deficiency a rare disorder that causes premature breakdown of blood clots and a moderate bleeding syndrome. while spontaneous bleeding is rare, moderate hemorrhages of the knees, elbows, nose and gums may be triggered by mild trauma. in females, menstrual bleeding is often severe. prolonged bleeding after surgery is also common.  pai-1 deficiency is caused by homozygous or compound heterozygous mutation in the serpine1 gene.  fibrinolysis inhibitors, including epsilon-aminocaproic acid and tranexamic acid, are usually effective in treating and preventing bleeding episodes. last updated: 1/19/2012

MalaCards based summary: Plasminogen Activator Inhibitor-1 Deficiency, also known as plasminogen activator inhibitor type 1 deficiency, is related to myocardial infarction and inherited blood coagulation disease, and has symptoms including menorrhagia An important gene associated with Plasminogen Activator Inhibitor-1 Deficiency is SERPINE1 (Serpin Family E Member 1), and among its related pathways are Apelin signaling pathway and Folate Metabolism. Affiliated tissues include endothelial, lung and bone.

OMIM:52 Plasminogen inhibitor-1 deficiency is a rare autosomal recessive hematologic disorder characterized by increased... (613329) more...

UniProtKB/Swiss-Prot:70 Plasminogen activator inhibitor-1 deficiency: A hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.

Wikipedia:71 Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or... more...

Related Diseases for Plasminogen Activator Inhibitor-1 Deficiency

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Diseases related to Plasminogen Activator Inhibitor-1 Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction29.1PLAT, SERPINE1, SERPINF2
2inherited blood coagulation disease10.0SERPINE1, SERPINF2
3giant papillary conjunctivitis10.0SERPINE1, SERPINF2
4peanut allergy10.0PLAT, SERPINF2
5ductal carcinoma in situ10.0PLAT, SERPINF2
6septic myocarditis10.0PLAT, SERPINF2
7hennekam lymphangiectasia-lymphedema syndrome 29.9PLAT, SERPINF2
8cerebral calcifications opalescent teeth phosphaturia9.9PLAT, SERPINE1
9brazilian hemorrhagic fever9.9PLAT, SERPINE1
10aids dementia complex9.9PLAT, SERPINF2
11monocular exotropia9.9PLAT, SERPINE1
12perrault syndrome9.9PLAT, SERPINE1
13obesity9.9
14zika virus congenital syndrome9.9PLAT, SERPINE1
15xerophthalmia9.9PLAT, SERPINE1
16immunodeficiency, common variable, 69.9PLAT, SERPINE1
17congenital chloride diarrhea9.9PLAT, SERPINE1
18bone development disease9.9PLAT, SERPINE1
19endotheliitis9.9
20cervix small cell carcinoma9.9PLAT, SERPINE1
21budd-chiari syndrome9.8PLAT, SERPINE1
22pyrimidine metabolic disorder9.8PLAT, SERPINE1
23pericarditis9.8PLAT, SERPINE1
24sydenham chorea9.8PLAT, SERPINE1
25atherosclerosis9.8
26osteogenesis imperfecta9.8
27pneumonia9.8
28macular degeneration, age-related, 129.8PLAT, SERPINE1
29inflammatory bowel disease 119.8PLAT, SERPINE1, SERPINF2
30chronic fatigue syndrome9.7PLAT, SERPINE1, SERPINF2
31secretory diarrhea myopathy and deafness9.7PLAT, SERPINE1, SERPINF2
32sezary's disease9.7PLAT, SERPINE1, SERPINF2
33lynch syndrome9.7PLAT, SERPINE1, SERPINF2
34pregnancy loss, recurrent 19.7PLAT, SERPINE1, SERPINF2
35brill-zinsser disease9.7PLAT, SERPINE1, SERPINF2
36leukocyte disease9.7PLAT, SERPINE1, SERPINF2
37adult t-cell leukemia9.7PLAT, SERPINE1, SERPINF2
38melioidosis9.7
39chordoma9.7
40acute myocardial infarction9.7
41choroiditis9.7
42fibrosarcoma9.7
43hypertension, essential9.7PLAT, SERPINE1

Graphical network of the top 20 diseases related to Plasminogen Activator Inhibitor-1 Deficiency:



Diseases related to plasminogen activator inhibitor-1 deficiency

Symptoms & Phenotypes for Plasminogen Activator Inhibitor-1 Deficiency

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Symptoms by clinical synopsis from OMIM:

613329

Clinical features from OMIM:

613329

Human phenotypes related to Plasminogen Activator Inhibitor-1 Deficiency:

 64
id Description HPO Frequency HPO Source Accession
1 menorrhagia64 HP:0000132

Drugs & Therapeutics for Plasminogen Activator Inhibitor-1 Deficiency

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Drugs for Plasminogen Activator Inhibitor-1 Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Tenofovirapproved, investigationalPhase 4759147127-20-6464205
Synonyms:
(R)-9-(2-Phosphonomethoxypropyl)adenine
(R)-9-(2-Phosphonylmethoxypropyl)adenine
(R)-9-(2-phosphonomethoxypropyl)adenine
(R)-PMPA
147127-20-6
206184-49-8
AC-760
AC1LA9BO
Anh. tenofovir
Anhydrous tenofovir
Apropovir
CHEBI:45809
CHEMBL483
CID464205
D,L-Tenofovir
DB00300
GNA & Tenofovir
GS 1275
GS 1278
GS1278
 
HHA & Tenofovir
KS-5021
MolPort-003-850-411
NCGC00167535-01
PMPA
PMPA-(R)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Galanthus nivalis agglutinin (GNA)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Hippeastrum hybrid agglutinin( HHA)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- (9CI)
Phosphonic acid, [[2-(6-amino-9H-purin-9
S1401_Selleck
TDF
TFV
Tenefovir
Tenofovir
Tenofovir (anh.)
Tenofovir disoproxil
Tenofovir disoproxil fumarate
UNII-99YXE507IL
Viread
Viread, Tenofovir
[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
2
Nitric OxideapprovedPhase 461710102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique
3
Acetylcysteineapproved, investigationalPhase 4330616-91-112035
Synonyms:
(2R)-2-acetylamino-3-sulfanylpropanoic acid
(R)-2-acetylamino-3-mercaptopropanoic acid
(R)-mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
Fluprowit
 
L-Acetylcysteine
L-acetylcysteine
L-α-acetamido-β-mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetyl-L-(+)-cysteine
N-acetyl-L-cysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
4Anti-HIV AgentsPhase 43162
5Reverse Transcriptase InhibitorsPhase 41913
6Antiviral AgentsPhase 49967
7Anti-Infective AgentsPhase 422062
8Nucleic Acid Synthesis InhibitorsPhase 44962
9Anti-Retroviral AgentsPhase 43296
10Neurotransmitter AgentsPhase 418340
11Peripheral Nervous System AgentsPhase 423689
12Vasodilator AgentsPhase 43543
13ExpectorantsPhase 4404
14Respiratory System AgentsPhase 44997
15Protective AgentsPhase 47443
16N-monoacetylcystinePhase 4330
17Anti-Asthmatic AgentsPhase 43488
18Endothelium-Dependent Relaxing FactorsPhase 4281
19AntidotesPhase 41071
20AntioxidantsPhase 43050
21Bronchodilator AgentsPhase 42965
22Autonomic AgentsPhase 410150
23Omega 3 Fatty AcidNutraceuticalPhase 41018
24arginineNutraceuticalPhase 4425
25Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 313168
26Hormone AntagonistsPhase 313180
27HormonesPhase 314415
28
Ergocalciferolapproved, nutraceuticalPhase 2128150-14-65280793
Synonyms:
'Ergosterol irradiated'
(+)-Vitamin D2
(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol
(3S,5Z,7E,14xi,17alpha,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3beta,5Z,7e,22e)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
(5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
22-Tetraen 3beta 9,10,Secoergosta-5,7,10(19)-ol
31316-19-5
4-Methylene-3-[2-[tetrahydro-7a-methyl-1-(1,4,5-trimethyl-2-hexenyl)-4(3aH)-indanylidene]ethylidene]-Cyclohexanol
47768_SUPELCO
50-14-6
7489-18-1
7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87
8017-28-5
9,10,Secoergosta-5,7,10(19),22-tetraen 3.beta.-ol
9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3b-ol
95220_FLUKA
95220_SIGMA
AC-1355
AC1L1FIE
AC1NQXLH
AC1NS4DE
AC1NS9GI
AC1NSSVD
AC1NWAM3
AC1O5EDK
AC1O6WAM
ACon1_002187
Activated ergosterol
BPBio1_000418
BSPBio_000380
BSPBio_001974
Buco-D
C05441
C28H44O
CALCIFEROL IN A GELATIN MATRIX
CALCIFEROL, U.S.P.
CHEBI:28934
CHEMBL1536
CID11003810
CID3249
CID5280793
CID5315257
CID5353610
CID5356615
CID5702050
CID6432478
CID6536972
Calciferol
Calciferol (TN)
Calciferol (vitamin D2)
Calciferolum
Calciferon 2
Condacaps
Condocaps
Condol
Crtron
Crystallina
D-Arthin
D-Tracetten
D00187
DB00153
Daral
Davitamon D
Davitin
De-rat concentrate
Decaps
Dee-Osterol
Dee-Ron
Dee-Ronal
Dee-Roual
Deltalin
Deratol
Detalup
Diactol
Divit urto
Doral
Drisdol
Drisdol (TN)
E5750_SIGMA
EINECS 200-014-9
Ercalciol
Ergocalciferol
Ergocalciferol (D2)
Ergocalciferol (JP15/USP)
Ergocalciferol [INN:BAN:JAN]
Ergocalciferol oil
Ergocalciferol: Vitamin D
 
Ergocalciferolo
Ergocalciferolo [DCIT]
Ergocalciferols
Ergocalciferolum
Ergocalciferolum [INN-Latin]
Ergorone
Ergosterol activated
Ergosterol irradiated
Ergosterol, irradiated
Ertron
Fortodyl
Geltabs
Geltabs Vitamin D
HMS1920K20
HMS2091B19
HMS502I07
HSDB 819
Haliver
Hi-Deratol
Hyperkil
I05-0022
IDI1_000805
Infron
Irradiated ergosta-5,7,22-trien-3-beta-ol
Irradiated ergosta-5,7,22-trien-3.beta.-ol
Irradiated ergosta-5,7,22-trien-3beta-ol
Irradiated ergosterol
LMST03010001
LMST03010014
LS-3228
MEGxm0_000466
MLS001332467
MLS001332468
Metadee
Mina D2
MolPort-001-740-057
MolPort-001-793-930
MolPort-002-526-645
MolPort-003-666-178
MolPort-006-822-629
Mulsiferol
Mykostin
NCGC00142497-01
NCGC00179579-01
NCGC00179579-02
NSC 62792
NSC62792
Novovitamin-D
Oleovitamin D
Oleovitamin D, Synthetic
Oleovitamin D2
Osteil
Ostelin
Prestwick3_000420
Prestwick_554
Radiostol
Radstein
Radsterin
Rodine C
Rodinec
SMR000857106
SPECTRUM1500276
ST057150
STOCK1N-53397
Shock-ferol
Shock-ferol sterogyl
Sorex C.R
Sorex C.R.
Spectrum5_000666
Sterogyl
Synthetic Vitamin D
UNII-VS041H42XC
Uvesterol D
Uvesterol-D
VITAMIN D2
VITAMIN D2 WATER DISPERSABLE U.S.P.
VITAMIN_D2
Vigantol
Vio D
Vio-D
Viostdrol
Viosterol
Viosterol in Oil
Vitamin D2
Vitamin- D2
Vitamin-?D2
Vitamina D2
Vitavel-D
WLN: L56 FYTJ A1 BY1&1U1Y1&Y1&1 FU2U- BL6YYTJ AU1 DQ
ZINC04474571
ZINC04629876
beta-Ol
bmse000510
component of Geltabs Vitamin D
delta-Arthin
delta-Tracetten
ergocalciferol
vitamin d-2
29
Cholecalciferolapproved, nutraceuticalPhase 287567-97-06221, 10883523, 5280795
Synonyms:
()-Vitamin D3
(+)-Vitamin D3
(+)-vitamin D3
(1S,3Z)-3-[(2e)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
(3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(5E,7E)-9,10-Secocholesta-5,7,10-trien-3-ol
(5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatrien-3-ol
(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol
1406-16-2
25(OH)D
3-beta,Z,7E-9,10-Secocholestr-5,7,10(19)-trien-3-ol
47763_SUPELCO
57651-82-8
67-97-0
7-Dehydrocholesterol activated
7-Dehydrocholesterol, Activated
7-Dehydrocholesterol, irradiated
7-Dehydrocholestrol, activated
8024-19-9
8050-67-7
89193_FLUKA
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3-ol
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3beta-ol
9,10-Secocholesta-5(Z),7(E),10(19)-trien-3(.beta.)-ol
9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol
9,10-Secocholesta-5,7,10(19)-trien-3-ol
9,10-Secocholesta-5,7,10-trien-3-ol
AB1002422
AC-11697
AC1L1ECK
AC1L1M23
AC1LU7IZ
AC1NQXLN
AC1NR2UO
AC1NR2UR
AC1NR2UU
AC1NS4AJ
AC1NSHJX
AC1O5EOF
AC1O7GAV
AC1O7GQ3
AC1O8FEU
AC1O8PWJ
AC1OF2GI
AC1OF2GL
AC1OIEW5
AC1OIEWB
ACon1_001997
Activated 7-dehydrocholesterol
Arachitol
BPBio1_000460
BSPBio_000418
BSPBio_002408
Bio-0845
C05443
C1357_SIAL
C27H44O
C9756_SIGMA
C9774_SIAL
CAS-67-97-0
CC
CCRIS 5813
CCRIS 6286
CHEBI:283119
CHEBI:28940
CHEMBL1042
CHEMBL432780
CID10000117
CID10045875
CID10340013
CID10883523
CID10894379
CID11014566
CID11025493
CID11058152
CID11463269
CID1548921
CID2735
CID5280795
CID5283710
CID5283711
CID5283712
CID5353527
CID5363362
CID6221
CID6432644
CID6604201
CID6604662
CID6708595
CID6713938
CID6992015
CID6992016
CID7067439
CID7067440
CID7251172
CID7251174
CID9821465
Calciol
Cholecalciferol
Cholecalciferol (D3)
Cholecalciferol (JP15/USP)
Cholecalciferol D3
Cholecalciferol [USAN:BAN:JAN]
Cholecalciferol, D3
Cholecalciferolum
Colecalciferol
 
Colecalciferol (INN)
Colecalciferolo
Colecalciferolo [DCIT]
Colecalciferolum
Colecalciferolum [INN-Latin]
Colecalcipherol
D00188
D3-Vicotrat
D3-Vigantol
DB00169
Delsterol
Delta-D
Delta-D (TN)
Deparal
Devaron
DivK1c_006276
Duphafral D3 1000
EINECS 200-673-2
EINECS 215-797-2
EPA Pesticide Chemical Code 202901
Ebivit
FeraCol
Granuvit D3
HMS1569E20
HMS2092M12
HSDB 820
I05-0041
Irradiated 7-dehydrocholesterol
KBio1_001220
KBio2_001643
KBio2_004211
KBio2_006779
KBio3_001628
KBioGR_001602
KBioSS_001643
LMST03020001
LMST03020219
LMST03020220
LMST03020221
LS-1570
LS-825
LT00244775
MEGxm0_000458
Micro-dee
MolPort-001-740-051
MolPort-001-785-972
MolPort-003-666-021
MolPort-004-946-964
NCGC00016301-01
NCGC00017328-01
NCGC00091072-01
NCGC00142511-01
NCGC00159331-02
NCGC00159331-04
NCGC00178668-01
NCGC00179565-01
NCGC00179565-02
NEO Dohyfral D3
NSC 375571
NSC-375571
NSC375571
Oleovitamin D3
Prestwick0_000429
Prestwick1_000429
Prestwick2_000429
Prestwick3_000429
Prestwick_63
Provitamine
Provitina
Quintox
Rampage
Ricketon
SMP1_000068
SPBio_001298
SPBio_002357
SR-05000001559
SR-05000001559-3
ST057172
SpecPlus_000180
Spectrum2_001369
Spectrum3_000764
Spectrum4_001201
Spectrum_001163
TNP00266
Trivitan
UNII-1C6V77QF41
UPCMLD-DP152
UPCMLD-DP152:001
VITAMIN D
VITAMIN D3 POWDER
VITAMIN_D3
Vi-De3
Vi-de-3-hydrosol
VidDe-3-hydrosol
Videkhol
Vigantol
Vigorsan
Vitamin D-3
Vitamin D3
Vitamin D3 emulsifiable
Vitinc Dan-Dee-3
ZINC04474460
ZINC04492874
ZINC04492875
ZINC04492876
ZINC04492878
bmse000507
cholecalciferol
colecalciferolum
vitamin d-3
30Trace ElementsPhase 26001
31vitamin dPhase 21724
32MicronutrientsPhase 26001
33VitaminsPhase 25282
34Bone Density Conservation AgentsPhase 23376
35Insulin, Globin ZincPhase 24645
36ErgocalciferolsPhase 21281
37insulinPhase 24646
38CalciferolNutraceuticalPhase 21383
39Vitamin D2NutraceuticalPhase 21281

Interventional clinical trials:

idNameStatusNCT IDPhase
1Metabolic Impact Assessment of Tenofovir Disoproxil Fumarate on Non-HIV-1 Infected Healthy Adult Male VolunteersCompletedNCT00648817Phase 4
2Omacor and Cardiovascular Risk Factors in HIV Patients on HAART TreatmentCompletedNCT00296153Phase 4
3N-Acetylcysteine and Arginine Administration in Diabetic PatientsTerminatedNCT00569465Phase 4
4Low and Conventional Dose of Somatropin in Growth Hormone Deficient Adult PatientsCompletedNCT00570011Phase 3
5Metabolic Syndrome and Insulin Resistance at AllinaCompletedNCT01545830Phase 2
6Evaluating an Exercise Program to Reduce Cardiovascular Risk Factors in Children Infected With HIVCompletedNCT00908284
7HIV and Cardiovascular RiskCompletedNCT00465426

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Genetic Tests for Plasminogen Activator Inhibitor-1 Deficiency

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Genetic tests related to Plasminogen Activator Inhibitor-1 Deficiency:

id Genetic test Affiliating Genes
1 Plasminogen Activator Inhibitor Type 1 Deficiency27
2 Plasminogen Activator Inhibitor-1 Deficiency24 SERPINE1

Anatomical Context for Plasminogen Activator Inhibitor-1 Deficiency

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MalaCards organs/tissues related to Plasminogen Activator Inhibitor-1 Deficiency:

36
Endothelial, Lung, Bone, Smooth muscle

Publications for Plasminogen Activator Inhibitor-1 Deficiency

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Articles related to Plasminogen Activator Inhibitor-1 Deficiency:

(show all 17)
idTitleAuthorsYear
1
Organizing empyema induced in mice by Streptococcus pneumoniae: effects of plasminogen activator inhibitor-1 deficiency. (27271877)
2016
2
High-fat Diet Enhances and Plasminogen Activator Inhibitor-1 Deficiency Attenuates Bone Loss in Mice with Lewis Lung Carcinoma. (26124329)
2015
3
Plasminogen activator inhibitor-1 deficiency augments visceral mesothelial organization, intrapleural coagulation, and lung restriction in mice with carbon black/bleomycin-induced pleural injury. (24024554)
2014
4
Plasminogen activator inhibitor-1 deficiency ameliorates insulin resistance and hyperlipidemia but not bone loss in obese female mice. (24605827)
2014
5
Life-threatening hemorrhage and prolonged wound healing are remarkable phenotypes manifested by complete plasminogen activator inhibitor-1 deficiency in humans. (21486382)
2011
6
Intraparenchymal hemorrhage in a patient with osteogenesis imperfecta and plasminogen activator inhibitor-1 deficiency. (20142533)
2010
7
Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury. (19060228)
2009
8
Plasminogen activator inhibitor-1 deficiency protects against aldosterone-induced glomerular injury. (16528256)
2006
9
Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice. (16735799)
2006
10
Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy. (15780082)
2005
11
Effect of plasminogen activator inhibitor-1 deficiency on nutritionally-induced obesity in mice. (15886793)
2005
12
Plasminogen activator inhibitor-1 deficiency enhances flow-induced smooth muscle cell migration. (15262486)
2004
13
Report of a case of congenital plasminogen activator inhibitor-1 deficiency]. (15182577)
2004
14
Anesthetic management of a patient with congenital plasminogen activator inhibitor-1 deficiency]. (12632627)
2003
15
Plasminogen activator inhibitor-1 deficiency prevents hypertension and vascular fibrosis in response to long-term nitric oxide synthase inhibition. (11502712)
2001
16
Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery. (11110693)
2000
17
Four cases of bleeding diathesis in children due to congenital plasminogen activator inhibitor-1 deficiency. (10754381)
1999

Variations for Plasminogen Activator Inhibitor-1 Deficiency

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Clinvar genetic disease variations for Plasminogen Activator Inhibitor-1 Deficiency:

5
id Gene Variation Type Significance SNP ID Assembly Location
1SERPINE1SERPINE1, 2-BP INS, 4977TAinsertionPathogenic

Expression for genes affiliated with Plasminogen Activator Inhibitor-1 Deficiency

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Search GEO for disease gene expression data for Plasminogen Activator Inhibitor-1 Deficiency.

Pathways for genes affiliated with Plasminogen Activator Inhibitor-1 Deficiency

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GO Terms for genes affiliated with Plasminogen Activator Inhibitor-1 Deficiency

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Cellular components related to Plasminogen Activator Inhibitor-1 Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310129.8PLAT, SERPINE1
2platelet alpha granule lumenGO:00310939.3SERPINE1, SERPINF2
3extracellular spaceGO:00056159.0PLAT, SERPINE1, SERPINF2

Biological processes related to Plasminogen Activator Inhibitor-1 Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of endopeptidase activityGO:00109519.9SERPINE1, SERPINF2
2negative regulation of fibrinolysisGO:00519189.9SERPINE1, SERPINF2
3negative regulation of peptidase activityGO:00104669.9SERPINE1, SERPINF2
4negative regulation of plasminogen activationGO:00107579.9SERPINE1, SERPINF2
5platelet degranulationGO:00025769.3SERPINE1, SERPINF2
6fibrinolysisGO:00427309.1PLAT, SERPINE1, SERPINF2

Molecular functions related to Plasminogen Activator Inhibitor-1 Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptidase inhibitor activityGO:00304149.9SERPINE1, SERPINF2
2protease bindingGO:00020209.9SERPINE1, SERPINF2
3serine-type endopeptidase inhibitor activityGO:00048679.3SERPINE1, SERPINF2

Sources for Plasminogen Activator Inhibitor-1 Deficiency

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet