Plasminogen Deficiency malady

Wikipedia: Plasmin is an important enzyme (EC 3.4.21.7) present in blood that degrades many blood plasma proteins,...⁴⁴ more...

MalaCards: Plasminogen Deficiency, also known as hypoplasminogenemia, is related to thromboembolism and intracranial thrombosis. An important gene associated with Plasminogen Deficiency is PLG (plasminogen), and among its related pathways are Complement and coagulation cascades and Blood Coagulation Signaling Pathways. The compounds ecotin and nafamostat mesilate have been mentioned in the context of this disorder.

plasminogen deficiency 7 hypoplasminogenemia 43

Disease types for plasminogen deficiency family:

type 1 plasminogen deficiency	plasminogen deficiency, types i and ii

Diseases related to plasminogen deficiency by text searches and GeneDecks gene sharing:

(show top 50)    (show all 71)

id	Related Disease	Score	Top Affiliating Genes
1	thromboembolism	27.2	F5, PLG
2	intracranial thrombosis	12.8	F5, PLG
3	antithrombin iii deficiency	12.8	F5, PLG
4	hereditary angioedema	12.8	F5, PLG
5	protein c deficiency	12.8	PLG, F5
6	pulmonary embolism	12.8	PLG, F5
7	deep vein thrombosis	12.8	PLG, F5
8	angioedema	12.7	F5, PLG
9	thrombophilia	12.7	PLG, F5
10	osteonecrosis	12.7	PLG, F5
11	cerebrovascular accident	12.6	F5, PLG
12	protein s deficiency	12.6	PLG, F5
13	endophthalmitis	12.6	ELANE, F5
14	cerebral infarction	12.6	F5, PLG
15	diabetic ketoacidosis	12.6	F5, ELANE
16	chronic venous leg ulcers	12.6	F5, ELANE
17	hemorrhagic fever	12.6	F5, PLG
18	venous insufficiency	12.6	ELANE, F5
19	primary pulmonary hypertension	12.5	F5, ELANE
20	obstructive jaundice	12.5	F5, ELANE
21	septic shock	12.5	ELANE, F5
22	pulmonary function	12.5	F5, ELANE
23	contact dermatitis	12.5	F5, ELANE
24	conjunctivitis ligneous	12.5	PLG, ELANE
25	intracranial aneurysm	12.5	F5, ELANE
26	respiratory failure	12.5	ELANE, F5
27	interstitial lung disease	12.5	ELANE, F5
28	wegener's granulomatosis	12.5	ELANE, F5
29	jaundice	12.5	ELANE, F5
30	aneurysm disease	12.5	ELANE, PLG
31	otitis media	12.5	ELANE, F5
32	aspergillosis	12.4	PLG, ELANE
33	viral hepatitis	12.4	ELANE, F5
34	hepatopulmonary syndrome	12.4	PLG, ELANE
35	vascular disease	12.3	F5, ELANE
36	abdominal aortic aneurysm	12.1	F5, ELANE
37	acute promyelocytic leukemia	12.1	ELANE, F5
38	acute pancreatitis	12.0	F5, ELANE
39	adult respiratory distress syndrome	12.0	F5, PLG, ELANE
40	newborn respiratory distress syndrome	12.0	PLG, ELANE, F5
41	alcoholic hepatitis	12.0	ELANE, PLG, F5
42	disseminated intravascular coagulation	12.0	F5, PLG, ELANE
43	severe acute respiratory syndrome	12.0	F5, PLG, ELANE
44	factor v leiden thrombophilia	12.0	F5, PLG, ELANE
45	sepsis	12.0	PLG, ELANE, F5
46	vasculitis	12.0	F5, ELANE, PLG
47	acute myocardial infarction	12.0	F5, PLG, ELANE
48	glomerulonephritis	12.0	ELANE, F5, PLG
49	thrombosis	12.0	ELANE, PLG, F5
50	coronary heart disease	12.0	ELANE, PLG, F5

Approved drugs:

Drug clinical trials:

Articles related to plasminogen deficiency:

id	Title	Authors	Year	Affiliating Genes
1	Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice. (17722076)	Roszell N.J.... Joiner C.H.	2007	PLG
2	Characterization of plasminogen variants in healthy subjects and plasminogen mutants in patients with inherited plasminogen deficiency by isoelectric focusing gel electrophoresis. (15269832)	Tefs K.... Schuster V.	2004	PLG
3	Combined heterozygous plasminogen deficiency and factor V Leiden defect in the same kindred. (10726047)	Sartori M.T.... Girolami A.	2000	F5
4	Polymorphonuclear elastase in patients with homozygous type I plasminogen deficiency and ligneous conjunctivitis. (10066157)	Mingers A.M.... Kreth H.W.	1998	ELANE
5	Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency. (9834305)	Schott D.... Kramer M.D.	1998	PLG
6	Is plasminogen deficiency a thrombotic risk factor? A study on 23 thrombophilic patients and their family members. (9684804)	Demarmels Biasiutti F.... Lammle B.	1998	PLG
7	Recurrent venous thromboembolic disease and factor XI concentrate in a patient with severe factor XI deficiency, chronic myelomonocytic leukaemia, factor V Leiden and heterozygous plasminogen deficiency. (9391725)	Evans G.... Perry D.J.	1997	F5
8	Homozygous type I plasminogen deficiency. (9255907)	Mingers A.M.... Schuster V.	1997	PLG
9	Congenital plasminogen deficiency caused by a Ser-572 to Pro mutation. (8392398)	Azuma H.... Saito S.	1993	PLG

Genes related to plasminogen deficiency according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PLG	plasminogen	11.0	Publications
2	ELANE	elastase, neutrophil expressed	11.0	Publications
3	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications

Pathways related to plasminogen deficiency according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Complement and coagulation cascades20	9.3	F5, PLG
2	Blood Coagulation Signaling Pathways37	9.2	F5, PLG
3	Cell adhesion_Cell-matrix glycoconjugates41	8.7	PLG, ELANE

Compounds related to plasminogen deficiency according to GeneDecks:

(show all 23)

id	Compound	Score	Top Affiliating Genes
1	ecotin32	9.5	ELANE, F5
2	nafamostat mesilate32	9.5	ELANE, F5
3	vancomycin32 9 9	11.5	F5, ELANE
4	gabexate mesilate32	9.4	ELANE, F5
5	protamine32	9.4	F5, ELANE
6	dermatan sulfate32	9.3	F5, ELANE
7	nacl32	9.3	F5, PLG
8	epsilon aminocaproic acid32	9.3	PLG, ELANE
9	dextran sulfate32	9.3	F5, ELANE
10	alginate32	9.3	PLG, ELANE
11	leupeptin32	9.3	PLG, ELANE
12	sodium dodecylsulfate32	9.3	ELANE, F5
13	captopril32 42 9 9	12.3	ELANE, PLG
14	hydrocortisone32 9 9	11.2	F5, ELANE
15	endotoxin32	9.1	ELANE, F5
16	prostacyclin32	9.0	ELANE, F5
17	benzamidine32 9 9	10.9	ELANE, PLG, F5
18	kininogen32	8.9	ELANE, F5, PLG
19	aprotinin32 9 9	10.9	F5, PLG, ELANE
20	aspirin32 34 18	10.8	ELANE, F5
21	fibrinogen32	8.8	F5, ELANE, PLG
22	heparin32 9 18 9	11.8	F5, PLG, ELANE
23	cysteine32	8.6	PLG, ELANE, F5

Cellular components related to plasminogen deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.0	F5, PLG
2	extracellular region	GO:005576	8.5	F5, PLG, ELANE

Biological processes related to plasminogen deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet activation	GO:030168	9.3	F5, PLG
2	platelet degranulation	GO:002576	9.2	F5, PLG
3	extracellular matrix disassembly	GO:022617	9.0	PLG, ELANE
4	extracellular matrix organization	GO:030198	8.7	PLG, ELANE

Molecular functions related to plasminogen deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase activity	GO:004252	9.0	PLG, ELANE