MCID: PLS007
MIFTS: 57

Plasmodium Falciparum Malaria malady

Infectious diseases category
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Summaries for Plasmodium Falciparum Malaria

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Disease Ontology:8 A malaria described as a severe form of the disease caused by a parasite plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever.

MalaCards based summary: Plasmodium Falciparum Malaria, also known as malignant tertian fever, is related to malaria and cerebral malaria. An important gene associated with Plasmodium Falciparum Malaria is HP (haptoglobin), and among its related pathways is Sulfation Biotransformation Reaction. The drugs chloroquine and chloroquine phosphate and the compounds thiobarbituric acid and 23-diphosphoglycerate have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and monocytes, and related mouse phenotype cardiovascular system.

Aliases & Classifications for Plasmodium Falciparum Malaria

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Plasmodium Falciparum Malaria, Aliases & Descriptions:

Name: Plasmodium Falciparum Malaria 8 62
Malignant Tertian Fever 8 62
Plasmodium Falciparum Malaria, Unspecified 8
Malaria Fever, Subtertian 8
 
Malaria, Falciparum 62
Falciparum Malaria 8
Malaria Falciparum 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology8 DOID:14067
NCIt39 C34798
ICD9CM27 084.0
MeSH34 D016778
ICD1025 B50, B50.0, B50.9

Related Diseases for Plasmodium Falciparum Malaria

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Graphical network of the top 20 diseases related to Plasmodium Falciparum Malaria:



Diseases related to plasmodium falciparum malaria

Symptoms for Plasmodium Falciparum Malaria

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Drugs & Therapeutics for Plasmodium Falciparum Malaria

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Genetic Tests for Plasmodium Falciparum Malaria

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Anatomical Context for Plasmodium Falciparum Malaria

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MalaCards organs/tissues related to Plasmodium Falciparum Malaria:

32
Testes, T cells, Monocytes, Neutrophil, Endothelial, Brain, Spleen, Placenta, Nk cells, B cells, Hypothalamus, Cardiac myocytes, Pituitary

Animal Models for Plasmodium Falciparum Malaria or affiliated genes

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MGI Mouse Phenotypes related to Plasmodium Falciparum Malaria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1SLC4A1, HP, FABP3, RFX5, G6PD

Publications for Plasmodium Falciparum Malaria

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Articles related to Plasmodium Falciparum Malaria:

(show top 50)    (show all 601)
idTitleAuthorsYear
1
The diminishing returns of atovaquone-proguanil for elimination of Plasmodium falciparum malaria: modelling mass drug administration and treatment. (25249272)
2014
2
Treatment of imported Plasmodium falciparum malaria: role of the combination of dihydroartemisinin and piperaquine. (25296031)
2014
3
Estimated risk of placental infection and low birthweight attributable to Plasmodium falciparum malaria in Africa in 2010: a modelling study. (25103519)
2014
4
Exploring putative molecular mechanisms of human pyruvate kinase enzyme deficiency and its role in resistance against Plasmodium falciparum malaria. (25172454)
2014
5
Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. (23645841)
2013
6
Safety and immunogenicity of heterologous prime-boost immunisation with Plasmodium falciparum malaria candidate vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in healthy Gambian and Kenyan adults. (23526949)
2013
7
Therapeutic efficacy of fixed dose artesunate-mefloquine for the treatment of acute, uncomplicated Plasmodium falciparum malaria in Kampong Speu, Cambodia. (24060207)
2013
8
Zinc, copper and C-reactive protein in children with severe Plasmodium falciparum malaria in an area of unstable malaria transmission in eastern Sudan. (23104565)
2013
9
Comparative evaluation of efficacy and safety of artesunate-lumefantrine vs. artemether-lumefantrine fixed-dose combination in the treatment of uncomplicated Plasmodium falciparum malaria. (23489465)
2013
10
Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. (22665809)
2012
11
Large-scale growth of the Plasmodium falciparum malaria parasite in a wave bioreactor. (22326740)
2012
12
Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria. (23071567)
2012
13
Dihydroartemisinin/Piperaquine: a review of its use in the treatment of uncomplicated Plasmodium falciparum malaria. (22515619)
2012
14
Antigen-specific B memory cell responses to Plasmodium falciparum malaria antigens and Schistosoma haematobium antigens in co-infected Malian children. (22693628)
2012
15
Iron deficiency and severe Plasmodium falciparum malaria. (22354918)
2012
16
Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial. (23113947)
2012
17
Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique. (23295747)
2012
18
Therapeutic efficacy of artesunate in the treatment of uncomplicated Plasmodium falciparum malaria and anti-malarial, drug-resistance marker polymorphisms in populations near the China-Myanmar border. (22898135)
2012
19
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. (21689454)
2011
20
Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum Malaria. (21459194)
2011
21
Symmetrical peripheral gangrene and neurological manifestations in Plasmodium falciparum malaria. (22315752)
2011
22
In vivo efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in Central Ethiopia. (21798054)
2011
23
Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy. (20105282)
2010
24
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
25
Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria. (19946607)
2010
26
The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis. (20098724)
2010
27
Dose-dependent risk of neutropenia after 7-day courses of artesunate monotherapy in Cambodian patients with acute Plasmodium falciparum malaria. (21070142)
2010
28
Plasmodium falciparum malaria detected by HRP-2 antigenemia before microscopic- and PCR-positive conversion. (20421630)
2010
29
Artemisinin derivatives for treatment of uncomplicated Plasmodium falciparum malaria in Sudan: too early for too much hope. (20012990)
2010
30
Dihydroartemisinin-piperaquine versus artemether-lumefantrine, in the treatment of uncomplicated Plasmodium falciparum malaria in central Sudan. (20659392)
2010
31
Endoglin in African children with Plasmodium falciparum malaria: a novel player in severe malaria pathogenesis? (19919302)
2009
32
Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. (19138388)
2009
33
Atorvastatin is a promising partner for antimalarial drugs in treatment of Plasmodium falciparum malaria. (19307369)
2009
34
Activities of artesunate and amodiaquine against intestinal helminth in children with Plasmodium falciparum malaria in endemic areas. (18266013)
2008
35
Taste-masked quinine sulphate pellets: bio-availability in adults and steady-state plasma concentrations in children with uncomplicated Plasmodium falciparum malaria. (18510819)
2008
36
Gametocyte clearance in uncomplicated and severe Plasmodium falciparum malaria after artesunate-mefloquine treatment in Thailand. (18552540)
2008
37
Plasmodium falciparum malaria and atovaquone-proguanil treatment failure. (18258131)
2008
38
Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand. (18180343)
2008
39
Febrile Plasmodium falciparum malaria 4 years after exposure in a man with sickle cell disease. (18616395)
2008
40
Adherence and efficacy of supervised versus non-supervised treatment with artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh: a randomised controlled trial. (18606428)
2008
41
Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria. (17325227)
2007
42
Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children. (16766006)
2006
43
Therapeutic efficacy of sulfadoxin/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Enseno, Meskan Woreda, Gurage zone, SNNPR, Ethiopia. (17447375)
2006
44
Plasmodium falciparum malaria in Jamaica, October-December 2006. (17213567)
2006
45
Suppression of RANTES in children with Plasmodium falciparum malaria. (17018392)
2006
46
An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos). (16903879)
2006
47
Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria? (16002039)
2005
48
Detection of anti-neutrophil cytoplasmic antibodies after acute Plasmodium falciparum malaria. (8770517)
1996
49
Plasmodium falciparum malaria: its effects on some haematological parameters in normal and sickle cell Nigerian children. (7899791)
1994
50
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. (1978068)
1990

Variations for Plasmodium Falciparum Malaria

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Expression for genes affiliated with Plasmodium Falciparum Malaria

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Expression patterns in normal tissues for genes affiliated with Plasmodium Falciparum Malaria

Search GEO for disease gene expression data for Plasmodium Falciparum Malaria.

Pathways for genes affiliated with Plasmodium Falciparum Malaria

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Pathways related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4G6PD, SULT1A3

Compounds for genes affiliated with Plasmodium Falciparum Malaria

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 24HMDB
See all sources

Compounds related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1thiobarbituric acid4410.0G6PD, HP
223-diphosphoglycerate4410.0HP, G6PD
3sulfadoxine/pyrimethamine4410.0DHFR, G6PD
4fansidar4410.0DHFR, G6PD
5sulfadoxine50 4411.0DHFR, G6PD
6atovaquone44 1111.0G6PD, DHFR
7zinc protoporphyrin4410.0G6PD, HP
8halofantrine44 1111.0G6PD, DHFR
9artesunate44 5011.0G6PD, DHFR
10pyrimethamine28 50 44 1113.0DHFR, G6PD
11hind iii4410.0SULT1A3, HP
12amodiaquine44 50 1112.0DHFR, G6PD
13mefloquine44 50 1112.0G6PD, DHFR
14trimethoprim50 44 1112.0G6PD, DHFR
15pentamidine44 1110.9G6PD, DHFR
16tocopherol449.9HP, G6PD
17prpp449.9G6PD, DHFR
18sulfamethoxazole50 44 1111.9G6PD, DHFR
19starch449.9HP, G6PD
20sulfonamide449.9DHFR, G6PD
21cellulose acetate449.9HP, G6PD
22dapsone44 2 50 1112.9DHFR, G6PD
23sulfasalazine28 44 50 1112.8HP, G6PD
24lactose44 1110.7G6PD, HP, DHFR
25chloroquine44 2 50 28 1113.7DHFR, G6PD, HP
26vitamin b12449.6G6PD, HP
27phospholipid449.5SLC4A1, HP, FABP3
28ascorbic acid44 2410.5HP, G6PD, DHFR
29vitamin-e449.5HP, G6PD, SULT1A3
30salicylic acid44 2810.5SLC4A1, SULT1A3, G6PD
31hypoxanthine44 24 1111.5DHFR, G6PD
32aspirin44 50 28 2412.5SULT1A3, HP, G6PD
33phenol44 2410.4SULT1A3, G6PD
34epinephrine44 24 1111.4HP, SULT1A3, G6PD
35folate449.4SLC4A1, G6PD, DHFR, HP
36ribavirin44 50 1111.3HP, G6PD
37norepinephrine44 24 1111.3NPPC, SULT1A3, FABP3
38fibrinogen449.3SULT1A3, CHIT1, HP
39cholesterol44 28 24 1112.2FABP3, SULT1A3, HP, SLC4A1
40adenylate449.2HP, NPPC, G6PD, DHFR
41nitric oxide44 24 1111.2NPPC, SULT1A3, SLC4A1, HP
42aspartate449.1SULT1A3, DHFR, HP, G6PD
43cysteine449.0HP, NPPC, SLC4A1, DHFR
44estrogen449.0SULT1A3, DHFR, HP, G6PD
45citrate449.0G6PD, SLC4A1, HP, DHFR, FABP3
46lactate449.0SLC4A1, HP, DHFR, FABP3, G6PD
47atp44 289.9NPPC, HP, G6PD, SLC4A1
48glucose448.8G6PD, SLC4A1, NPPC, HP, FABP3
49creatinine448.7NPPC, FABP3, G6PD, SULT1A3, HP
50lipid447.7HP, FABP3, CHIT1, G6PD, SULT1A3, SLC4A1

GO Terms for genes affiliated with Plasmodium Falciparum Malaria

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Biological processes related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to ethanolGO:0454719.5NPPC, G6PD

Products for genes affiliated with Plasmodium Falciparum Malaria

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  • Antibodies
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Sources for Plasmodium Falciparum Malaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet