MCID: PLS007
MIFTS: 63

Plasmodium Falciparum Malaria malady

Infectious diseases category

Summaries for Plasmodium Falciparum Malaria

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A malaria described as a severe form of the disease caused by a parasite plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever.

MalaCards: Plasmodium Falciparum Malaria, also known as plasmodium falciparum malaria, unspecified, is related to malaria and plasmodium vivax malaria. An important gene associated with Plasmodium Falciparum Malaria is HP (haptoglobin), and among its related pathways are Malaria and IL27-mediated signaling events. The drugs proguanil and chloroquine and the compounds pentoxifylline and sulfadoxine/pyrimethamine have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and monocytes, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Aliases & Classifications for Plasmodium Falciparum Malaria

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

plasmodium falciparum malaria 8
plasmodium falciparum malaria, unspecified 8
malaria fever, subtertian 8
malignant tertian fever 8
malaria, falciparum 60
falciparum malaria 8
malaria falciparum 44


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Disease Ontology8 DOID:14067
MeSH34 D016778
ICD9CM27 084.0
NCIt39 C34798
ICD1025 B50, B50.0, B50.9

Related Diseases for Plasmodium Falciparum Malaria

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17GeneCards, 18GeneDecks
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Diseases related to Plasmodium Falciparum Malaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1malaria32.5IFNG, SLC4A1, HP, DHFR, IL10, MIF
2plasmodium vivax malaria31.0DHFR, G6PD
3hepatitis30.9IL18, HP
4thrombocytopenia30.8CHIT1, HP
5cerebral malaria30.8IFNG, IL10, HP, MIF, G6PD
6asthma30.6IFNG, IL18, MIF, IL10, CHIT1, NPPC
7sickle cell disease30.4HP, G6PD
8pancreatitis30.4SULT1A3, IL10
9glomerulonephritis30.4RBP4, MIF
10dermatitis30.4IFNG, IL18
11sickle cell anemia30.4HP, G6PD
12acute pancreatitis30.4IL18, MIF, IL10, SULT1A3
13atopic dermatitis30.4MIF, IFNG, IL10, IL18
14glucosephosphate dehydrogenase deficiency30.4HP, G6PD
15hereditary elliptocytosis30.4SLC4A1, G6PD
16hemoglobinopathy30.4G6PD, HP
17melanoma30.4DHFR, IFNG, SLC4A1, IL10
18pancytopenia30.4DHFR, HP
19sarcoma30.4DHFR
20alpha thalassemia30.1G6PD, CHIT1, SLC4A1
21plasmodium malariae malaria11.7
22malaria, severe10.7
23cerebritis10.5
24acalculous cholecystitis10.4
25hepatitis a10.4
26cerebellar ataxia10.4
27cholecystitis10.4
28schistosomiasis10.4
29purpura10.4
30mixed malaria10.3
31mononeuritis multiplex10.3
32amelanotic melanoma10.3
33adult respiratory distress syndrome10.3
34hepatitis e10.3
35q fever10.3
36splenic abscess10.3
37plasmodium ovale malaria10.3
38acute disseminated encephalomyelitis10.3
39adult syndrome10.3
40metabolic acidosis10.3
41cranial nerve palsy10.3
42encephalomyelitis10.3
43eosinophilia10.3
44hepatic encephalopathy10.3
45mononeuritis10.3
46neutropenia10.3
47polyneuropathy10.3
48malignant histiocytosis10.3
49kaposi's sarcoma10.3
50histiocytosis10.3

Graphical network of the top 20 diseases related to Plasmodium Falciparum Malaria:



Diseases related to plasmodium falciparum malaria

Clinical Features for Plasmodium Falciparum Malaria

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Drugs & Therapeutics for Plasmodium Falciparum Malaria

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Plasmodium Falciparum Malaria

Drug clinical trials:

Search ClinicalTrials for Plasmodium Falciparum Malaria

Search NIH Clinical Center for Plasmodium Falciparum Malaria

Search CenterWatch for Plasmodium Falciparum Malaria

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Plasmodium Falciparum Malaria

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Anatomical Context for Plasmodium Falciparum Malaria

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32MalaCards
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MalaCards organs/tissues related to Plasmodium Falciparum Malaria:

32
Testes, T cells, Monocytes, Endothelial, Liver, Brain, Nk cells, Hypothalamus, Placenta, Pituitary, B cells, Whole blood, Cardiac myocytes

Animal Models for Plasmodium Falciparum Malaria or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Plasmodium Falciparum Malaria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.1NPPC, FABP3, G6PD, RBP4, MIF, HP
2MP:00053859.9TEAD2, IFNG, FABP3, G6PD, RBP4, HP

Publications for Plasmodium Falciparum Malaria

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50PubMed
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Articles related to Plasmodium Falciparum Malaria:

(show top 50)    (show all 779)
idTitleAuthorsYear
1
Effectiveness of Co-trimoxazole to Prevent Plasmodium falciparum Malaria in HIV-Positive Pregnant Women in Sub-Saharan Africa: An Open-Label, Randomized Controlled Trial. (24336820)
2014
2
Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial. (24239324)
2014
3
Naturally Acquired Antibodies Specific for Plasmodium falciparum Reticulocyte-Binding Protein Homologue 5 Inhibit Parasite Growth and Predict Protection From Malaria. (24133188)
2013
4
Evaluation of CareStarta8c malaria Pf/Pv combo test for Plasmodium falciparum and Plasmodium vivax malaria diagnosis in Butajira area, south-central Ethiopia. (23805822)
2013
5
Exploration of in vivo efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in under fives in Tabora region, Tanzania. (23399782)
2013
6
Hemoglobinopathies: slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis. (23696730)
2013
7
Dynamics of malaria transmission and susceptibility to clinical malaria episodes following treatment of Plasmodium falciparum asymptomatic carriers: results of a cluster-randomized study of community-wide screening and treatment, and a parallel entomology study. (24215306)
2013
8
Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development. (23776179)
2013
9
Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania. (22632033)
2012
10
Cochrane Column * Rapid diagnostic tests can extend access of diagnostic services for uncomplicated Plasmodium falciparum malaria * Commentary: Rapid diagnostic tests for diagnosing uncomplicated Plasmodium falciparum malaria in endemic countries (Review) * Approach to conducting Cochrane Diagnostic Test Accuracy Reviews. (22798691)
2012
11
Anaemia & expression levels of CD35, CD55 & CD59 on red blood cells in Plasmodium falciparum malaria patients from India. (21727667)
2011
12
Effect of quinine therapy on plasma glucose and plasma insulin levels in pregnant women infected with Plasmodium falciparum malaria in Gezira state. (22259921)
2011
13
Autoantibody against dendrite in Plasmodium falciparum infection: a singular auto-immune phenomenon preferentially in cerebral malaria. (21315059)
2011
14
A case of successfully treated acute respiratory distress syndrome complicating Plasmodium falciparum malaria. (21329251)
2011
15
Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria. (21451007)
2011
16
Acute acalculous cholecystitis complicating an imported case of mixed malaria caused by Plasmodium falciparum and Plasmodium vivax. (19932042)
2010
17
Schistosomiasis coinfection in children influences acquired immune response against Plasmodium falciparum malaria antigens. (20856680)
2010
18
The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria. (20180933)
2010
19
High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya. (20530796)
2010
20
Artesunate Plus Amodiaquine (AS+AQ) Versus Artemether -Lumefantrine (AL) for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Sub-Saharan Africa-A Meta-Analysis. (23878697)
2010
21
The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia. (20939876)
2010
22
Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. (19138388)
2009
23
Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparum malaria on oral therapy. (19390740)
2009
24
Functional dissection of the catalytic carboxyl-terminal domain of origin recognition complex subunit 1 (PfORC1) of the human malaria parasite Plasmodium falciparum. (19633266)
2009
25
PfeIK1, a eukaryotic initiation factor 2alpha kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation. (19435497)
2009
26
Artemisinin resistance in Plasmodium falciparum malaria. (19864681)
2009
27
The spectrum of retinopathy in adults with Plasmodium falciparum malaria. (19344925)
2009
28
The case for outpatient treatment of Plasmodium falciparum malaria in a selected UK immigrant population. (19706306)
2009
29
Comparison of sulfadoxine-pyrimethamine, unsupervised artemether-lumefantrine, and unsupervised artesunate-amodiaquine fixed-dose formulation for uncomplicated plasmodium falciparum malaria in Benin: a randomized effectiveness noninferiority trial. (19469703)
2009
30
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum. (18522386)
2008
31
A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya. (19017387)
2008
32
Efficacies of artesunate plus either sulfadoxine-pyrimethamine or amodiaquine, for the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan. (17244406)
2007
33
Variant-specific antibodies to merozoite surface protein 2 and clinical expression of Plasmodium falciparum malaria in rural Amazonians. (17556615)
2007
34
Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal. (17570848)
2007
35
Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children. (16766006)
2006
36
Comparison of different diagnostic techniques in Plasmodium falciparum cerebral malaria. (17175704)
2006
37
CD4 T cells from malaria-nonexposed individuals respond to the CD36-Binding Domain of Plasmodium falciparum erythrocyte membrane protein-1 via an MHC class II-TCR-independent pathway. (16622019)
2006
38
Overproduction of Pichia pastoris or Plasmodium falciparum protein disulfide isomerase affects expression, folding and O-linked glycosylation of a malaria vaccine candidate expressed in P. pastoris. (16274825)
2006
39
Efficacy of three artemisinin combination therapies for the treatment of uncomplicated Plasmodium falciparum malaria in the Republic of Congo. (17125496)
2006
40
Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia. (16996149)
2006
41
Human recombinant antibodies against Plasmodium falciparum merozoite surface protein 3 cloned from peripheral blood leukocytes of individuals with immunity to malaria demonstrate antiparasitic properties. (16714549)
2006
42
Myosin-like sequences in the malaria parasite Plasmodium falciparum bind human erythrocyte membrane protein 4.1. (15477199)
2004
43
A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. (14694201)
2004
44
Serum levels of soluble urokinase plasminogen activator receptor is associated with parasitemia in children with acute Plasmodium falciparum malaria infection. (15491469)
2004
45
Chloroquine, sulfadoxine-pyrimethamine and amodiaquine efficacy for the treatment of uncomplicated Plasmodium falciparum malaria in Upper Nile, south Sudan. (14584383)
2003
46
Choloroquine-resistant Plasmodium falciparum malaria in an extremely premature infant. (17283465)
1999
47
The rapid manual ParaSight-F test for diagnosing Plasmodium Falciparum malaria in Saudi Arabia. (17337962)
1999
48
A MAP kinase homologue from the human malaria parasite, Plasmodium falciparum. (8921836)
1996
49
Molecular characterization of the heat shock protein 90 gene of the human malaria parasite Plasmodium falciparum. (7838176)
1994
50
Neither heparin nor acetylsalicylic acid influence the clinical course in human Plasmodium falciparum malaria: a prospective randomized study. (1951871)
1991

Genetic Variations for Plasmodium Falciparum Malaria

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Expression for genes affiliated with Plasmodium Falciparum Malaria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plasmodium Falciparum Malaria

Search GEO for disease gene expression data for Plasmodium Falciparum Malaria.

Pathways for genes affiliated with Plasmodium Falciparum Malaria

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29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN
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Pathways related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL18
2
Hide members
10.4IL18, IL10, IFNG
310.4IL18, IL10, IFNG
410.4IL18, IL10, IFNG
5
Hide members
10.3KLRC1, IFNG, IL10, IL18

Compounds for genes affiliated with Plasmodium Falciparum Malaria

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44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.8IL18
2sulfadoxine/pyrimethamine4410.8G6PD, DHPS, DHFR
3fansidar4410.8DHFR, DHPS, G6PD
4sulfadoxine49 4411.8DHPS, G6PD, DHFR
5atovaquone44 1111.8DHPS, DHFR, G6PD
6dexamethasone44 49 28 1113.8RBP4, SULT1A3, NPPC
7artesunate44 4911.8DHFR, G6PD, DHPS
8pyrimethamine28 49 44 1113.8G6PD, DHPS, DHFR
9cyclophosphamide44 49 1112.8MIF, G6PD, DHFR
10creatinine4410.7HP, RBP4, NPPC, FABP3, SULT1A3
11ribavirin44 49 1112.7IL18, IFNG, HP, IL10, G6PD
12tuberculin4410.7IL10, IL18, MIF, IFNG, HP
13con a4410.7IL18, HP, IL10, IFNG
14trimethoprim44 49 1112.7G6PD, DHPS, DHFR
15aspartate4410.7RBP4, SULT1A3, G6PD, DHFR
16neopterin4410.7IL18, HP, IL10, CHIT1, IFNG
17pentamidine44 1111.7DHFR, G6PD, IFNG
18citrate4410.7SLC4A1, FABP3, G6PD, HP, DHFR
19natalizumab44 1111.7IL10, IL18, IFNG
20chloroquine44 2 49 28 1114.7IL10, G6PD, IL18, HP, DHFR, DHPS
21lactose44 1111.7HP, G6PD, MIF, DHFR
22sulfamethoxazole44 49 1112.7DHPS, G6PD, DHFR
23glucose4410.7SLC4A1, RBP4, FABP3, NPPC, HSPA14
24il-124410.7IL18, IL10, IFNG
25folate4410.7G6PD, RBP4, HP, DHPS, SLC4A1, DHFR
26vitamin-e4410.7SULT1A3, HP, RBP4, G6PD
27thalidomide44 49 59 1113.7IFNG, MIF, IL10, IL18
28imiquimod44 28 59 1113.7IFNG, IL10, IL18
29sulfonamide4410.7DHFR, DHPS, G6PD
30lactate4410.7SLC4A1, IL18, DHFR, HP, MIF, RBP4
31dapsone2 44 49 1113.6DHPS, DHFR, G6PD
32tocopherol4410.6HP, RBP4, G6PD
33homocysteine44 2411.6HP, SULT1A3, IL18, MIF
34norepinephrine44 11 2412.6NPPC, SULT1A3, FABP3
35serine4410.6ABO, IL18, DHPS, HP, MIF, RBP4
36nitric oxide44 11 2412.6SLC4A1, SULT1A3, IL10, HP, NPPC, MIF
37adenylate4410.6DHFR, IL18, HP, G6PD, NPPC, RBP4
38p0024410.6IL18, HP, FABP3, RBP4
39cysteine4410.6IFNG, NPPC, RBP4, MIF, HP, DHFR
40lipid4410.6MIF, CHIT1, G6PD, NPPC, HP, IL18
41alanine4410.6IL18, ABO, RBP4, MIF, DHFR, HP
42cellulose acetate4410.5G6PD, RBP4, HP
43dihydropteroate4410.5DHPS, DHFR
44gm-csf44 2811.5IFNG, IL10
45estrogen4410.4IL18, HP, MIF, SULT1A3, DHFR, RBP4
46retinoic acid44 2411.3NPPC, IFNG, MIF, DHFR, IL18, HSPA14
47cholesterol44 28 11 2413.3FABP3, HP, SULT1A3, IL18, SLC4A1, RBP4
48steroid4410.2RBP4, MIF, HP, IL18, SULT1A3, HSPA14
49simvastatin44 49 59 28 11 2415.2IL18, IL10, RBP4, IFNG
50thyroxine44 2411.0HP, IL10, RBP4, G6PD

GO Terms for genes affiliated with Plasmodium Falciparum Malaria

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16Gene Ontology
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Cellular components related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.2IFNG, NPPC, RBP4, MIF, HP, IL18
2extracellular spaceGO:0056159.9IFNG, NPPC, RBP4, CHIT1, MIF, HP

Biological processes related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1type 2 immune responseGO:04209210.6IL18, IL10
2response to insulin stimulusGO:03286810.5IL10, RBP4, FABP3
3positive regulation of MHC class II biosynthetic processGO:04534810.5IFNG, IL10
4response to ethanolGO:04547110.4RBP4, G6PD, NPPC
5negative regulation of growth of symbiont in hostGO:04413010.4IL10, IFNG
6response to drugGO:04249310.3IFNG, NPPC, FABP3, IL10
7inflammatory responseGO:00695410.2NCR3, MIF, IL10, IL18
8defense response to bacteriumGO:04274210.1IL10, HP, IFNG

Molecular functions related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.3IL18, IL10, MIF, IFNG

Products for genes affiliated with Plasmodium Falciparum Malaria

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  • Antibodies
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Sources for Plasmodium Falciparum Malaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet