MCID: PLS007
MIFTS: 59

Plasmodium Falciparum Malaria malady

Infectious category

Summaries for Plasmodium Falciparum Malaria

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A malaria described as a severe form of the disease caused by a parasite plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever.

MalaCards: Plasmodium Falciparum Malaria, also known as plasmodium falciparum malaria, unspecified, is related to plasmodium vivax malaria and thrombocytopenia. An important gene associated with Plasmodium Falciparum Malaria is HP (haptoglobin), and among its related pathways are Malaria and IL27-mediated signaling events. The drugs chloroquine and chloroquine phosphate and the compounds pentoxifylline and sulfadoxine/pyrimethamine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and liver, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Aliases & Classifications for Plasmodium Falciparum Malaria

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

plasmodium falciparum malaria 8
plasmodium falciparum malaria, unspecified 8
malaria fever, subtertian 8
malignant tertian fever 8
malaria, falciparum 61
falciparum malaria 8
malaria falciparum 45


External Ids:

Disease Ontology8 DOID:14067
MeSH35 D016778
ICD9CM27 084.0
NCIt40 C34798
ICD1025 B50, B50.0, B50.9

Related Diseases for Plasmodium Falciparum Malaria

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Plasmodium Falciparum Malaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1plasmodium vivax malaria31.0DHFR, G6PD
2thrombocytopenia30.8HP, CHIT1
3cerebral malaria30.8IL10, HP, MIF, G6PD, IFNG
4asthma30.7IFNG, NPPC, CHIT1, MIF, IL10, IL18
5sickle cell disease30.5G6PD, HP
6sickle cell anemia30.5G6PD, HP
7acute pancreatitis30.5MIF, IL10, IL18, SULT1A3
8hepatitis c30.5IFNG, HP, IL10, IL18
9atopic dermatitis30.5IFNG, MIF, IL10, IL18
10sepsis30.5RBP4, MIF, IL10, IL18, SULT1A3
11hereditary elliptocytosis30.5G6PD, SLC4A1
12thalassemia30.4G6PD, CHIT1, SLC4A1
13pancytopenia30.4DHFR, HP
14splenomegaly30.2HP, CHIT1
15malaria, severe11.2
16acalculous cholecystitis10.5
17hepatitis a10.5
18ataxia10.5
19malaria, mild10.5
20purpura fulminans10.4
21mixed malaria10.3
22mononeuritis multiplex10.3
23amelanotic melanoma10.3
24adult respiratory distress syndrome10.3
25hepatitis e10.3
26splenic abscess10.3
27plasmodium ovale malaria10.3
28acute disseminated encephalomyelitis10.3
29burkitt's lymphoma10.3
30adult syndrome10.3
31metabolic acidosis10.3
32brain injury10.3
33malignant histiocytosis10.3
34kaposi's sarcoma10.3
35meningococcal meningitis10.3
36hemoglobin d disease10.1
37tangier disease10.1
38acute diarrhea10.1
39subdural empyema10.1
40pulmonary edema10.1
41beta thalassemia10.1
42leptospirosis10.1
43alpha thalassemia10.1
44babesiosis10.1
45hypokalemia10.1
46megaloblastic anemia10.1
47hemolytic-uremic syndrome10.1
48kid syndrome10.1
49m�ni�re disease10.1
50bacteremia10.1

Graphical network of the top 20 diseases related to Plasmodium Falciparum Malaria:



Diseases related to plasmodium falciparum malaria

Clinical Features for Plasmodium Falciparum Malaria

Drugs & Therapeutics for Plasmodium Falciparum Malaria

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Plasmodium Falciparum Malaria

Drug clinical trials:

Search ClinicalTrials for Plasmodium Falciparum Malaria

Search NIH Clinical Center for Plasmodium Falciparum Malaria

Search CenterWatch for Plasmodium Falciparum Malaria

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Plasmodium Falciparum Malaria

Anatomical Context for Plasmodium Falciparum Malaria

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Plasmodium Falciparum Malaria:

33
Whole blood, Brain, Liver, Placenta, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Hypothalamus, Cardiac myocytes, Fetal liver, Pituitary

Animal Models for Plasmodium Falciparum Malaria or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Plasmodium Falciparum Malaria:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.1NPPC, FABP3, G6PD, RBP4, MIF, HP
2MP:00053859.9TEAD2, IFNG, FABP3, G6PD, RBP4, HP

Publications for Plasmodium Falciparum Malaria

Sources:
51PubMed
See all sources

Articles related to Plasmodium Falciparum Malaria:

(show top 50)    (show all 798)
idTitleAuthorsYear
1
Antibodies to a Single, Conserved Epitope in Anopheles APN1 Inhibit Universal Transmission of Plasmodium falciparum and Plasmodium vivax Malaria. (24324180)
2014
2
Two cases of Plasmodium falciparum malaria in the Netherlands without recent travel to a malaria-endemic country. (23857021)
2013
3
Systemic release of high mobility group box 1 (HMGB1) protein is associated with severe and fatal Plasmodium falciparum malaria. (23506269)
2013
4
Inter-relationships of cardinal features and outcomes of symptomatic pediatric Plasmodium falciparum MALARIA in 1,933 children in Kampala, Uganda. (23358640)
2013
5
Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. (22665809)
2012
6
Human cerebral malaria and Plasmodium falciparum genotypes in Malawi. (22314206)
2012
7
An outbreak of Plasmodium falciparum malaria in the Torres Strait. (23186217)
2012
8
Mild Plasmodium falciparum malaria following an episode of severe malaria is associated with induction of the interferon pathway in Malawian children. (22232187)
2012
9
Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population. (22734050)
2012
10
Effect of acute Plasmodium falciparum malaria on reactivation and shedding of the eight human herpes viruses. (22039454)
2011
11
Clinical Trial Report: Double-Dose Chloroquine for Treatment of Plasmodium falciparum Malaria in Guinea-Bissau. (21337121)
2011
12
Severe imported Plasmodium falciparum malaria, France, 1996-2003. (21529388)
2011
13
The Plasmodium falciparum malaria M1 alanyl aminopeptidase (PfA-M1): insights of catalytic mechanism and function from MD simulations. (22205955)
2011
14
The role of El NiA+o Southern Oscillation (ENSO) on variations of monthly Plasmodium falciparum malaria cases at the Cayenne General Hospital, 1996-2009, French Guiana. (21513502)
2011
15
Multicentric assessment of the efficacy and tolerability of dihydroartemisinin-piperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa. (21774826)
2011
16
Dose-dependent risk of neutropenia after 7-day courses of artesunate monotherapy in Cambodian patients with acute Plasmodium falciparum malaria. (21070142)
2010
17
Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial. (20417857)
2010
18
Symmetrical peripheral digital gangrene following severe Plasmodium falciparum malaria-induced disseminated intravascular coagulopathy. (20586820)
2010
19
Frequencies of some human genetic markers and their association with Plasmodium falciparum malaria in the Niger Delta, Nigeria. (20231768)
2010
20
Quantitation of CD36 (platelet glycoprotein IV) expression on platelets and monocytes by flow cytometry: application to the study of Plasmodium falciparum malaria. (18671254)
2009
21
Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition. (19300493)
2009
22
Unraveling the C-reactive protein complement-cascade in destruction of red blood cells: potential pathological implications in Plasmodium falciparum malaria. (19255512)
2009
23
Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent. (19022224)
2009
24
Febrile Plasmodium falciparum malaria 4 years after exposure in a man with sickle cell disease. (18616395)
2008
25
A randomized trial on effectiveness of artemether-lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated Plasmodium falciparum malaria in Ghanaian children. (19099594)
2008
26
Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh. (17255226)
2007
27
Haemoglobin C and S role in acquired immunity against Plasmodium falciparum malaria. (17912355)
2007
28
Artesunate, artemether or quinine in severe Plasmodium falciparum malaria? (17402835)
2007
29
The use of activated protein C in severe Plasmodium falciparum malaria. (17591142)
2007
30
Comparative protein modeling of spermidine synthase from Plasmodium falciparum: A potential target for anti-malarial drug therapy. (17597911)
2006
31
Plasmodium falciparum malaria in Jamaica, October-December 2006. (17213567)
2006
32
Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen-1 and thrombospondin-related adhesive protein in residents of a malaria holoendemic area. (16606988)
2006
33
Molecular genotyping to distinguish between recrudescents and new infections in treatment trials of Plasmodium falciparum malaria conducted in Sub-Saharan Africa: adjustment of parasitological outcomes and assessment of genotyping effectiveness. (16930256)
2006
34
Short course of quinine plus a single dose of sulfadoxine/pyrimethamine for Plasmodium falciparum malaria. (17136336)
2006
35
Safety and efficacy of lumefantrine-artemether (Coartem) for the treatment of uncomplicated Plasmodium falciparum malaria in Zambian adults. (16923176)
2006
36
Azithromycin combination therapy with artesunate or quinine for the treatment of uncomplicated Plasmodium falciparum malaria in adults: a randomized, phase 2 clinical trial in Thailand. (17051490)
2006
37
Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia. (16575721)
2006
38
The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzyme. (15913804)
2005
39
Acute disseminated encephalomyelitis following Plasmodium falciparum malaria caused by varicella zoster virus reactivation. (15827291)
2005
40
Plasmodium falciparum clonal population dynamics during malaria treatment. (14722883)
2004
41
The malaria parasite Plasmodium falciparum encodes members of the Puf RNA-binding protein family with conserved RNA binding activity. (12409450)
2002
42
Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia. (12228819)
2002
43
Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages. (11359831)
2001
44
Fresh isolates from children with severe Plasmodium falciparum malaria bind to multiple receptors. (11500463)
2001
45
Effect of pentoxifylline on cytokine patterns in the therapy of complicated Plasmodium falciparum malaria. (9546416)
1998
46
Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria. (9291905)
1997
47
Interleukin-10 inhibits tumor necrosis factor production but not antigen-specific lymphoproliferation in acute Plasmodium falciparum malaria. (7658079)
1995
48
Increased plasma levels of soluble IL-2R are associated with severe Plasmodium falciparum malaria. (8149674)
1994
49
The role of interleukin-6 in vitamin A deficiency during Plasmodium falciparum malaria and possible consequences for vitamin A supplementation. (1572702)
1992
50
Transient depletion of T cells with high LFA-1 expression from peripheral circulation during acute Plasmodium falciparum malaria. (1674690)
1991

Genetic Variations for Plasmodium Falciparum Malaria

Expression for genes affiliated with Plasmodium Falciparum Malaria

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Plasmodium Falciparum Malaria

Search GEO for disease gene expression data for Plasmodium Falciparum Malaria.

Pathways for genes affiliated with Plasmodium Falciparum Malaria

Sources:
30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 52QIAGEN
See all sources

Pathways related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL18
2
Hide members
10.4IL18, IL10, IFNG
310.4IL18, IL10, IFNG
410.4IL18, IL10, IFNG
5
Hide members
10.3KLRC1, IFNG, IL10, IL18

Compounds for genes affiliated with Plasmodium Falciparum Malaria

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1pentoxifylline45 1111.8IL18
2sulfadoxine/pyrimethamine4510.8G6PD, DHPS, DHFR
3fansidar4510.8DHFR, DHPS, G6PD
4sulfadoxine50 4511.8DHPS, G6PD, DHFR
5atovaquone45 1111.8DHPS, DHFR, G6PD
6dexamethasone45 50 29 1113.8RBP4, SULT1A3, NPPC
7artesunate45 5011.8DHFR, G6PD, DHPS
8pyrimethamine29 50 45 1113.8G6PD, DHPS, DHFR
9cyclophosphamide45 50 1112.8MIF, G6PD, DHFR
10creatinine4510.7HP, RBP4, NPPC, FABP3, SULT1A3
11ribavirin45 50 1112.7IL18, IFNG, HP, IL10, G6PD
12tuberculin4510.7IL10, IL18, MIF, IFNG, HP
13con a4510.7IL18, HP, IL10, IFNG
14trimethoprim45 50 1112.7G6PD, DHPS, DHFR
15aspartate4510.7RBP4, SULT1A3, G6PD, DHFR
16neopterin4510.7IL18, HP, IL10, CHIT1, IFNG
17pentamidine45 1111.7DHFR, G6PD, IFNG
18citrate4510.7SLC4A1, FABP3, G6PD, HP, DHFR
19natalizumab45 1111.7IL10, IL18, IFNG
20chloroquine45 2 50 29 1114.7IL10, G6PD, IL18, HP, DHFR, DHPS
21lactose45 1111.7HP, G6PD, MIF, DHFR
22sulfamethoxazole45 50 1112.7DHPS, G6PD, DHFR
23glucose4510.7SLC4A1, RBP4, FABP3, NPPC, HSPA14
24il-124510.7IL18, IL10, IFNG
25folate4510.7G6PD, RBP4, HP, DHPS, SLC4A1, DHFR
26vitamin-e4510.7SULT1A3, HP, RBP4, G6PD
27thalidomide45 50 60 1113.7IFNG, MIF, IL10, IL18
28imiquimod45 29 60 1113.7IFNG, IL10, IL18
29sulfonamide4510.7DHFR, DHPS, G6PD
30lactate4510.7SLC4A1, IL18, DHFR, HP, MIF, RBP4
31dapsone2 45 50 1113.6DHPS, DHFR, G6PD
32tocopherol4510.6HP, RBP4, G6PD
33homocysteine45 2411.6HP, SULT1A3, IL18, MIF
34norepinephrine45 11 2412.6NPPC, SULT1A3, FABP3
35serine4510.6ABO, IL18, DHPS, HP, MIF, RBP4
36nitric oxide45 11 2412.6SLC4A1, SULT1A3, IL10, HP, NPPC, MIF
37adenylate4510.6DHFR, IL18, HP, G6PD, NPPC, RBP4
38p0024510.6IL18, HP, FABP3, RBP4
39cysteine4510.6IFNG, NPPC, RBP4, MIF, HP, DHFR
40lipid4510.6MIF, CHIT1, G6PD, NPPC, HP, IL18
41alanine4510.6IL18, ABO, RBP4, MIF, DHFR, HP
42cellulose acetate4510.5G6PD, RBP4, HP
43dihydropteroate4510.5DHPS, DHFR
44gm-csf45 2911.5IFNG, IL10
45estrogen4510.4IL18, HP, MIF, SULT1A3, DHFR, RBP4
46retinoic acid45 2411.3NPPC, IFNG, MIF, DHFR, IL18, HSPA14
47cholesterol45 29 11 2413.3FABP3, HP, SULT1A3, IL18, SLC4A1, RBP4
48steroid4510.2RBP4, MIF, HP, IL18, SULT1A3, HSPA14
49simvastatin45 50 60 29 11 2415.2IL18, IL10, RBP4, IFNG
50thyroxine45 2411.0HP, IL10, RBP4, G6PD

GO Terms for genes affiliated with Plasmodium Falciparum Malaria

Sources:
16Gene Ontology
See all sources

Cellular components related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.2IFNG, NPPC, RBP4, MIF, HP, IL18
2extracellular spaceGO:0056159.9IFNG, NPPC, RBP4, CHIT1, MIF, HP

Biological processes related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1type 2 immune responseGO:04209210.6IL18, IL10
2response to insulin stimulusGO:03286810.5IL10, RBP4, FABP3
3positive regulation of MHC class II biosynthetic processGO:04534810.5IFNG, IL10
4response to ethanolGO:04547110.4RBP4, G6PD, NPPC
5negative regulation of growth of symbiont in hostGO:04413010.4IL10, IFNG
6response to drugGO:04249310.3IFNG, NPPC, FABP3, IL10
7inflammatory responseGO:00695410.2NCR3, MIF, IL10, IL18
8defense response to bacteriumGO:04274210.1IL10, HP, IFNG

Molecular functions related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.3IL18, IL10, MIF, IFNG

Products for genes affiliated with Plasmodium Falciparum Malaria

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Plasmodium Falciparum Malaria

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet