MCID: PLS007
MIFTS: 55

Plasmodium Falciparum Malaria malady

Infectious diseases category

Summaries for Plasmodium Falciparum Malaria

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A malaria described as a severe form of the disease caused by a parasite plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever.

MalaCards: Plasmodium Falciparum Malaria, also known as plasmodium falciparum malaria, unspecified, is related to malaria and plasmodium vivax malaria. An important gene associated with Plasmodium Falciparum Malaria is HP (haptoglobin), and among its related pathways is Sulfation Biotransformation Reaction. The drugs proguanil and chloroquine and the compounds 23-diphosphoglycerate and thiobarbituric acid have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and monocytes, and related mouse phenotype cardiovascular system.

Aliases & Classifications for Plasmodium Falciparum Malaria

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9Disease Ontology, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

plasmodium falciparum malaria 9
plasmodium falciparum malaria, unspecified 9
malaria fever, subtertian 9
malignant tertian fever 9
malaria, falciparum 63
falciparum malaria 9
malaria falciparum 46


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Disease Ontology9 DOID:14067
NCIt41 C34798
MeSH36 D016778
ICD9CM28 084.0
ICD1026 B50, B50.0, B50.9

Related Diseases for Plasmodium Falciparum Malaria

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Plasmodium Falciparum Malaria:



Diseases related to plasmodium falciparum malaria

Symptoms for Plasmodium Falciparum Malaria

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Drugs & Therapeutics for Plasmodium Falciparum Malaria

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Plasmodium Falciparum Malaria

Drug clinical trials:

Search ClinicalTrials for Plasmodium Falciparum Malaria

Search NIH Clinical Center for Plasmodium Falciparum Malaria

Search CenterWatch for Plasmodium Falciparum Malaria

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Plasmodium Falciparum Malaria

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Anatomical Context for Plasmodium Falciparum Malaria

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34MalaCards
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MalaCards organs/tissues related to Plasmodium Falciparum Malaria:

34
Testes, T cells, Monocytes, Endothelial, Brain, Nk cells, B cells, Placenta, Hypothalamus, Cardiac myocytes, Pituitary

Animal Models for Plasmodium Falciparum Malaria or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Plasmodium Falciparum Malaria:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1SLC4A1, HP, FABP3, RFX5, G6PD

Publications for Plasmodium Falciparum Malaria

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53PubMed
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Articles related to Plasmodium Falciparum Malaria:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. (23645841)
2013
2
Safety and immunogenicity of heterologous prime-boost immunisation with Plasmodium falciparum malaria candidate vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in healthy Gambian and Kenyan adults. (23526949)
2013
3
Therapeutic efficacy of fixed dose artesunate-mefloquine for the treatment of acute, uncomplicated Plasmodium falciparum malaria in Kampong Speu, Cambodia. (24060207)
2013
4
Zinc, copper and C-reactive protein in children with severe Plasmodium falciparum malaria in an area of unstable malaria transmission in eastern Sudan. (23104565)
2013
5
Comparative evaluation of efficacy and safety of artesunate-lumefantrine vs. artemether-lumefantrine fixed-dose combination in the treatment of uncomplicated Plasmodium falciparum malaria. (23489465)
2013
6
Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. (22665809)
2012
7
Large-scale growth of the Plasmodium falciparum malaria parasite in a wave bioreactor. (22326740)
2012
8
Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria. (23071567)
2012
9
Dihydroartemisinin/Piperaquine: a review of its use in the treatment of uncomplicated Plasmodium falciparum malaria. (22515619)
2012
10
Antigen-specific B memory cell responses to Plasmodium falciparum malaria antigens and Schistosoma haematobium antigens in co-infected Malian children. (22693628)
2012
11
Iron deficiency and severe Plasmodium falciparum malaria. (22354918)
2012
12
Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial. (23113947)
2012
13
Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique. (23295747)
2012
14
Therapeutic efficacy of artesunate in the treatment of uncomplicated Plasmodium falciparum malaria and anti-malarial, drug-resistance marker polymorphisms in populations near the China-Myanmar border. (22898135)
2012
15
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. (21689454)
2011
16
Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum Malaria. (21459194)
2011
17
Symmetrical peripheral gangrene and neurological manifestations in Plasmodium falciparum malaria. (22315752)
2011
18
In vivo efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in Central Ethiopia. (21798054)
2011
19
Anaemia & expression levels of CD35, CD55 & CD59 on red blood cells in Plasmodium falciparum malaria patients from India. (21727667)
2011
20
Placental Plasmodium falciparum malaria infection: operational accuracy of HRP2 rapid diagnostic tests in a malaria endemic setting. (22004666)
2011
21
Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy. (20105282)
2010
22
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
23
Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria. (19946607)
2010
24
The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis. (20098724)
2010
25
Dose-dependent risk of neutropenia after 7-day courses of artesunate monotherapy in Cambodian patients with acute Plasmodium falciparum malaria. (21070142)
2010
26
Plasmodium falciparum malaria detected by HRP-2 antigenemia before microscopic- and PCR-positive conversion. (20421630)
2010
27
Artemisinin derivatives for treatment of uncomplicated Plasmodium falciparum malaria in Sudan: too early for too much hope. (20012990)
2010
28
Dihydroartemisinin-piperaquine versus artemether-lumefantrine, in the treatment of uncomplicated Plasmodium falciparum malaria in central Sudan. (20659392)
2010
29
Endoglin in African children with Plasmodium falciparum malaria: a novel player in severe malaria pathogenesis? (19919302)
2009
30
Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. (19138388)
2009
31
Intrarectal quinine versus intravenous or intramuscular quinine for treating Plasmodium falciparum malaria. (19160229)
2009
32
Atorvastatin is a promising partner for antimalarial drugs in treatment of Plasmodium falciparum malaria. (19307369)
2009
33
Activities of artesunate and amodiaquine against intestinal helminth in children with Plasmodium falciparum malaria in endemic areas. (18266013)
2008
34
Taste-masked quinine sulphate pellets: bio-availability in adults and steady-state plasma concentrations in children with uncomplicated Plasmodium falciparum malaria. (18510819)
2008
35
Gametocyte clearance in uncomplicated and severe Plasmodium falciparum malaria after artesunate-mefloquine treatment in Thailand. (18552540)
2008
36
Plasmodium falciparum malaria and atovaquone-proguanil treatment failure. (18258131)
2008
37
Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand. (18180343)
2008
38
Febrile Plasmodium falciparum malaria 4 years after exposure in a man with sickle cell disease. (18616395)
2008
39
Adherence and efficacy of supervised versus non-supervised treatment with artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh: a randomised controlled trial. (18606428)
2008
40
Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria. (17325227)
2007
41
Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children. (16766006)
2006
42
Therapeutic efficacy of sulfadoxin/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Enseno, Meskan Woreda, Gurage zone, SNNPR, Ethiopia. (17447375)
2006
43
Plasmodium falciparum malaria in Jamaica, October-December 2006. (17213567)
2006
44
Suppression of RANTES in children with Plasmodium falciparum malaria. (17018392)
2006
45
An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos). (16903879)
2006
46
Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria? (16002039)
2005
47
Detection of anti-neutrophil cytoplasmic antibodies after acute Plasmodium falciparum malaria. (8770517)
1996
48
Increased serum concentrations of the carboxy-terminal-cross-linked telopeptide of collagen type I in patients with acute Plasmodium falciparum malaria. (8612346)
1996
49
Plasmodium falciparum malaria: its effects on some haematological parameters in normal and sickle cell Nigerian children. (7899791)
1994
50
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. (1978068)
1990

Variations for Plasmodium Falciparum Malaria

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Expression for genes affiliated with Plasmodium Falciparum Malaria

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plasmodium Falciparum Malaria

Search GEO for disease gene expression data for Plasmodium Falciparum Malaria.

Pathways for genes affiliated with Plasmodium Falciparum Malaria

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51PathCards, 39NCBI BioSystems Database
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Pathways related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4G6PD, SULT1A3

Compounds for genes affiliated with Plasmodium Falciparum Malaria

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 3BitterDB, 25HMDB
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Compounds related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate4610.0G6PD, HP
2thiobarbituric acid4610.0G6PD, HP
3sulfadoxine/pyrimethamine4610.0DHFR, G6PD
4fansidar4610.0DHFR, G6PD
5sulfadoxine52 4611.0G6PD, DHFR
6atovaquone46 1211.0DHFR, G6PD
7zinc protoporphyrin4610.0HP, G6PD
8halofantrine46 1211.0G6PD, DHFR
9artesunate46 5211.0DHFR, G6PD
10pyrimethamine30 52 46 1213.0G6PD, DHFR
11hind iii4610.0SULT1A3, HP
12amodiaquine46 52 1212.0DHFR, G6PD
13mefloquine46 52 1212.0G6PD, DHFR
14trimethoprim52 46 1212.0G6PD, DHFR
15pentamidine46 1210.9DHFR, G6PD
16tocopherol469.9HP, G6PD
17prpp469.9DHFR, G6PD
18sulfamethoxazole52 46 1211.9G6PD, DHFR
19starch469.9G6PD, HP
20sulfonamide469.9DHFR, G6PD
21cellulose acetate469.9HP, G6PD
22dapsone46 3 52 1212.9DHFR, G6PD
23sulfasalazine30 46 52 1212.8HP, G6PD
24lactose46 1210.7G6PD, DHFR, HP
25chloroquine46 3 52 30 1213.7HP, DHFR, G6PD
26vitamin b12469.6HP, G6PD
27phospholipid469.5FABP3, HP, SLC4A1
28ascorbic acid46 2510.5HP, DHFR, G6PD
29vitamin-e469.5HP, G6PD, SULT1A3
30salicylic acid46 3010.5SLC4A1, G6PD, SULT1A3
31hypoxanthine46 25 1211.5G6PD, DHFR
32aspirin46 52 30 2512.5HP, G6PD, SULT1A3
33phenol46 2510.4G6PD, SULT1A3
34epinephrine46 25 1211.4SULT1A3, G6PD, HP
35folate469.4SLC4A1, HP, DHFR, G6PD
36ribavirin46 52 1211.3HP, G6PD
37norepinephrine46 25 1211.3NPPC, FABP3, SULT1A3
38fibrinogen469.3HP, CHIT1, SULT1A3
39cholesterol46 30 25 1212.2SULT1A3, FABP3, HP, SLC4A1
40adenylate469.2G6PD, DHFR, HP, NPPC
41nitric oxide46 25 1211.2SLC4A1, NPPC, HP, SULT1A3
42aspartate469.1HP, DHFR, G6PD, SULT1A3
43cysteine469.0DHFR, HP, NPPC, SLC4A1
44estrogen469.0SULT1A3, G6PD, DHFR, HP
45citrate469.0SLC4A1, HP, DHFR, FABP3, G6PD
46lactate469.0G6PD, FABP3, DHFR, HP, SLC4A1
47atp46 309.9SLC4A1, NPPC, HP, G6PD
48glucose468.8G6PD, FABP3, HP, NPPC, SLC4A1
49creatinine468.7SULT1A3, G6PD, FABP3, HP, NPPC
50lipid467.7SULT1A3, G6PD, CHIT1, FABP3, HP, NPPC

GO Terms for genes affiliated with Plasmodium Falciparum Malaria

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17Gene Ontology
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Biological processes related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to ethanolGO:0454719.5NPPC, G6PD

Products for genes affiliated with Plasmodium Falciparum Malaria

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Plasmodium Falciparum Malaria

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet