MCID: PLS007
MIFTS: 56

Plasmodium Falciparum Malaria malady

Infectious diseases category

Summaries for Plasmodium Falciparum Malaria

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Disease Ontology:9 A malaria described as a severe form of the disease caused by a parasite plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever.

MalaCards based summary: Plasmodium Falciparum Malaria, also known as malignant tertian fever, is related to malaria and cerebral malaria. An important gene associated with Plasmodium Falciparum Malaria is HP (haptoglobin), and among its related pathways is Sulfation Biotransformation Reaction. The drugs chloroquine and chloroquine phosphate and the compounds 23-diphosphoglycerate and thiobarbituric acid have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and monocytes, and related mouse phenotype cardiovascular system.

Aliases & Classifications for Plasmodium Falciparum Malaria

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Sources:
9Disease Ontology, 44Novoseek, 61UMLS, 56SNOMED-CT, 39NCIt, 28ICD9CM, 34MeSH, 26ICD10
See all sources

Plasmodium Falciparum Malaria, Aliases & Descriptions:

Name: Plasmodium Falciparum Malaria 9 61
Malignant Tertian Fever 9 61
Plasmodium Falciparum Malaria, Unspecified 9
Malaria Fever, Subtertian 9
 
Malaria, Falciparum 61
Falciparum Malaria 9
Malaria Falciparum 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology9 DOID:14067
NCIt39 C34798
ICD9CM28 084.0
MeSH34 D016778
ICD1026 B50, B50.0, B50.9

Related Diseases for Plasmodium Falciparum Malaria

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Graphical network of the top 20 diseases related to Plasmodium Falciparum Malaria:



Diseases related to plasmodium falciparum malaria

Symptoms for Plasmodium Falciparum Malaria

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Drugs & Therapeutics for Plasmodium Falciparum Malaria

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Genetic Tests for Plasmodium Falciparum Malaria

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Anatomical Context for Plasmodium Falciparum Malaria

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MalaCards organs/tissues related to Plasmodium Falciparum Malaria:

32
Testes, T cells, Monocytes, Neutrophil, Endothelial, Brain, Spleen, Placenta, Nk cells, B cells, Hypothalamus, Cardiac myocytes, Pituitary

Animal Models for Plasmodium Falciparum Malaria or affiliated genes

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MGI Mouse Phenotypes related to Plasmodium Falciparum Malaria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1SLC4A1, HP, FABP3, RFX5, G6PD

Publications for Plasmodium Falciparum Malaria

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Articles related to Plasmodium Falciparum Malaria:

(show top 50)    (show all 601)
idTitleAuthorsYear
1
The diminishing returns of atovaquone-proguanil for elimination of Plasmodium falciparum malaria: modelling mass drug administration and treatment. (25249272)
2014
2
Treatment of imported Plasmodium falciparum malaria: role of the combination of dihydroartemisinin and piperaquine. (25296031)
2014
3
Estimated risk of placental infection and low birthweight attributable to Plasmodium falciparum malaria in Africa in 2010: a modelling study. (25103519)
2014
4
Exploring putative molecular mechanisms of human pyruvate kinase enzyme deficiency and its role in resistance against Plasmodium falciparum malaria. (25172454)
2014
5
Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. (23645841)
2013
6
Safety and immunogenicity of heterologous prime-boost immunisation with Plasmodium falciparum malaria candidate vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in healthy Gambian and Kenyan adults. (23526949)
2013
7
Therapeutic efficacy of fixed dose artesunate-mefloquine for the treatment of acute, uncomplicated Plasmodium falciparum malaria in Kampong Speu, Cambodia. (24060207)
2013
8
Zinc, copper and C-reactive protein in children with severe Plasmodium falciparum malaria in an area of unstable malaria transmission in eastern Sudan. (23104565)
2013
9
Comparative evaluation of efficacy and safety of artesunate-lumefantrine vs. artemether-lumefantrine fixed-dose combination in the treatment of uncomplicated Plasmodium falciparum malaria. (23489465)
2013
10
Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. (22665809)
2012
11
Large-scale growth of the Plasmodium falciparum malaria parasite in a wave bioreactor. (22326740)
2012
12
Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria. (23071567)
2012
13
Dihydroartemisinin/Piperaquine: a review of its use in the treatment of uncomplicated Plasmodium falciparum malaria. (22515619)
2012
14
Antigen-specific B memory cell responses to Plasmodium falciparum malaria antigens and Schistosoma haematobium antigens in co-infected Malian children. (22693628)
2012
15
Iron deficiency and severe Plasmodium falciparum malaria. (22354918)
2012
16
Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial. (23113947)
2012
17
Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique. (23295747)
2012
18
Therapeutic efficacy of artesunate in the treatment of uncomplicated Plasmodium falciparum malaria and anti-malarial, drug-resistance marker polymorphisms in populations near the China-Myanmar border. (22898135)
2012
19
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. (21689454)
2011
20
Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum Malaria. (21459194)
2011
21
Symmetrical peripheral gangrene and neurological manifestations in Plasmodium falciparum malaria. (22315752)
2011
22
In vivo efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in Central Ethiopia. (21798054)
2011
23
Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy. (20105282)
2010
24
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
25
Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria. (19946607)
2010
26
The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis. (20098724)
2010
27
Dose-dependent risk of neutropenia after 7-day courses of artesunate monotherapy in Cambodian patients with acute Plasmodium falciparum malaria. (21070142)
2010
28
Plasmodium falciparum malaria detected by HRP-2 antigenemia before microscopic- and PCR-positive conversion. (20421630)
2010
29
Artemisinin derivatives for treatment of uncomplicated Plasmodium falciparum malaria in Sudan: too early for too much hope. (20012990)
2010
30
Dihydroartemisinin-piperaquine versus artemether-lumefantrine, in the treatment of uncomplicated Plasmodium falciparum malaria in central Sudan. (20659392)
2010
31
Endoglin in African children with Plasmodium falciparum malaria: a novel player in severe malaria pathogenesis? (19919302)
2009
32
Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. (19138388)
2009
33
Atorvastatin is a promising partner for antimalarial drugs in treatment of Plasmodium falciparum malaria. (19307369)
2009
34
Activities of artesunate and amodiaquine against intestinal helminth in children with Plasmodium falciparum malaria in endemic areas. (18266013)
2008
35
Taste-masked quinine sulphate pellets: bio-availability in adults and steady-state plasma concentrations in children with uncomplicated Plasmodium falciparum malaria. (18510819)
2008
36
Gametocyte clearance in uncomplicated and severe Plasmodium falciparum malaria after artesunate-mefloquine treatment in Thailand. (18552540)
2008
37
Plasmodium falciparum malaria and atovaquone-proguanil treatment failure. (18258131)
2008
38
Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand. (18180343)
2008
39
Febrile Plasmodium falciparum malaria 4 years after exposure in a man with sickle cell disease. (18616395)
2008
40
Adherence and efficacy of supervised versus non-supervised treatment with artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh: a randomised controlled trial. (18606428)
2008
41
Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria. (17325227)
2007
42
Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children. (16766006)
2006
43
Therapeutic efficacy of sulfadoxin/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Enseno, Meskan Woreda, Gurage zone, SNNPR, Ethiopia. (17447375)
2006
44
Plasmodium falciparum malaria in Jamaica, October-December 2006. (17213567)
2006
45
Suppression of RANTES in children with Plasmodium falciparum malaria. (17018392)
2006
46
An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos). (16903879)
2006
47
Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria? (16002039)
2005
48
Detection of anti-neutrophil cytoplasmic antibodies after acute Plasmodium falciparum malaria. (8770517)
1996
49
Plasmodium falciparum malaria: its effects on some haematological parameters in normal and sickle cell Nigerian children. (7899791)
1994
50
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. (1978068)
1990

Variations for Plasmodium Falciparum Malaria

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Expression for genes affiliated with Plasmodium Falciparum Malaria

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Expression patterns in normal tissues for genes affiliated with Plasmodium Falciparum Malaria

Search GEO for disease gene expression data for Plasmodium Falciparum Malaria.

Pathways for genes affiliated with Plasmodium Falciparum Malaria

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Pathways related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4G6PD, SULT1A3

Compounds for genes affiliated with Plasmodium Falciparum Malaria

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Sources:
44Novoseek, 50PharmGKB, 12DrugBank, 29IUPHAR, 3BitterDB, 25HMDB
See all sources

Compounds related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate4410.0G6PD, HP
2thiobarbituric acid4410.0G6PD, HP
3sulfadoxine/pyrimethamine4410.0DHFR, G6PD
4fansidar4410.0DHFR, G6PD
5sulfadoxine50 4411.0G6PD, DHFR
6atovaquone44 1211.0DHFR, G6PD
7zinc protoporphyrin4410.0HP, G6PD
8halofantrine44 1211.0G6PD, DHFR
9artesunate44 5011.0DHFR, G6PD
10pyrimethamine29 50 44 1213.0G6PD, DHFR
11hind iii4410.0SULT1A3, HP
12amodiaquine44 50 1212.0DHFR, G6PD
13mefloquine44 50 1212.0G6PD, DHFR
14trimethoprim50 44 1212.0G6PD, DHFR
15pentamidine44 1210.9DHFR, G6PD
16tocopherol449.9HP, G6PD
17prpp449.9DHFR, G6PD
18sulfamethoxazole50 44 1211.9G6PD, DHFR
19starch449.9G6PD, HP
20sulfonamide449.9DHFR, G6PD
21cellulose acetate449.9HP, G6PD
22dapsone44 3 50 1212.9DHFR, G6PD
23sulfasalazine29 44 50 1212.8HP, G6PD
24lactose44 1210.7G6PD, DHFR, HP
25chloroquine44 3 50 29 1213.7HP, DHFR, G6PD
26vitamin b12449.6HP, G6PD
27phospholipid449.5FABP3, HP, SLC4A1
28ascorbic acid44 2510.5HP, DHFR, G6PD
29vitamin-e449.5HP, G6PD, SULT1A3
30salicylic acid44 2910.5SLC4A1, G6PD, SULT1A3
31hypoxanthine44 25 1211.5G6PD, DHFR
32aspirin44 50 29 2512.5HP, G6PD, SULT1A3
33phenol44 2510.4G6PD, SULT1A3
34epinephrine44 25 1211.4SULT1A3, G6PD, HP
35folate449.4SLC4A1, HP, DHFR, G6PD
36ribavirin44 50 1211.3HP, G6PD
37norepinephrine44 25 1211.3NPPC, FABP3, SULT1A3
38fibrinogen449.3HP, CHIT1, SULT1A3
39cholesterol44 29 25 1212.2SULT1A3, FABP3, HP, SLC4A1
40adenylate449.2G6PD, DHFR, HP, NPPC
41nitric oxide44 25 1211.2SLC4A1, NPPC, HP, SULT1A3
42aspartate449.1HP, DHFR, G6PD, SULT1A3
43cysteine449.0DHFR, HP, NPPC, SLC4A1
44estrogen449.0SULT1A3, G6PD, DHFR, HP
45citrate449.0SLC4A1, HP, DHFR, FABP3, G6PD
46lactate449.0G6PD, FABP3, DHFR, HP, SLC4A1
47atp44 299.9SLC4A1, NPPC, HP, G6PD
48glucose448.8G6PD, FABP3, HP, NPPC, SLC4A1
49creatinine448.7SULT1A3, G6PD, FABP3, HP, NPPC
50lipid447.7SULT1A3, G6PD, CHIT1, FABP3, HP, NPPC

GO Terms for genes affiliated with Plasmodium Falciparum Malaria

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Biological processes related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to ethanolGO:0454719.5NPPC, G6PD

Products for genes affiliated with Plasmodium Falciparum Malaria

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  • Antibodies
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  • Kits and Assays

Sources for Plasmodium Falciparum Malaria

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet