MCID: PLS007
MIFTS: 56

Plasmodium Falciparum Malaria malady

Infectious diseases category

Summaries for Plasmodium Falciparum Malaria

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Disease Ontology:10 A malaria described as a severe form of the disease caused by a parasite plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever.

MalaCards based summary: Plasmodium Falciparum Malaria, also known as malignant tertian fever, is related to malaria and plasmodium vivax malaria. An important gene associated with Plasmodium Falciparum Malaria is HP (haptoglobin), and among its related pathways is Sulfation Biotransformation Reaction. The drugs proguanil and chloroquine and the compounds 23-diphosphoglycerate and thiobarbituric acid have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and monocytes, and related mouse phenotype cardiovascular system.

Aliases & Classifications for Plasmodium Falciparum Malaria

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Sources:
10Disease Ontology, 62UMLS, 45Novoseek, 29ICD9CM, 40NCIt, 57SNOMED-CT, 35MeSH, 27ICD10
See all sources

Plasmodium Falciparum Malaria, Aliases & Descriptions:

Name: Plasmodium Falciparum Malaria 10 62
Malignant Tertian Fever 10 62
Plasmodium Falciparum Malaria, Unspecified 10
Malaria Fever, Subtertian 10
 
Malaria, Falciparum 62
Malaria Falciparum 45
Falciparum Malaria 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology10 DOID:14067
ICD9CM29 084.0
NCIt40 C34798
MeSH35 D016778
ICD1027 B50, B50.0, B50.9

Related Diseases for Plasmodium Falciparum Malaria

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Graphical network of the top 20 diseases related to Plasmodium Falciparum Malaria:



Diseases related to plasmodium falciparum malaria

Symptoms for Plasmodium Falciparum Malaria

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Drugs & Therapeutics for Plasmodium Falciparum Malaria

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Genetic Tests for Plasmodium Falciparum Malaria

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Anatomical Context for Plasmodium Falciparum Malaria

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MalaCards organs/tissues related to Plasmodium Falciparum Malaria:

33
Testes, T cells, Monocytes, Neutrophil, Endothelial, Brain, Liver, Skin, Placenta, Nk cells, B cells, Hypothalamus, Cardiac myocytes, Pituitary

Animal Models for Plasmodium Falciparum Malaria or affiliated genes

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MGI Mouse Phenotypes related to Plasmodium Falciparum Malaria:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1SLC4A1, HP, FABP3, RFX5, G6PD

Publications for Plasmodium Falciparum Malaria

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Articles related to Plasmodium Falciparum Malaria:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
PfRH5 as a candidate vaccine for Plasmodium falciparum malaria. (25704640)
2015
2
Polymorphisms in the Haem Oxygenase-1 promoter are not associated with severity of Plasmodium falciparum malaria in Ghanaian children. (25888733)
2015
3
Evaluation of Ebola Virus Inactivation Procedures for Plasmodium falciparum Malaria Diagnostics. (25631810)
2015
4
Mast cell activation in the skin of Plasmodium falciparum malaria patients. (25879828)
2015
5
The diminishing returns of atovaquone-proguanil for elimination of Plasmodium falciparum malaria: modelling mass drug administration and treatment. (25249272)
2014
6
Treatment of imported Plasmodium falciparum malaria: role of the combination of dihydroartemisinin and piperaquine. (25296031)
2014
7
Estimated risk of placental infection and low birthweight attributable to Plasmodium falciparum malaria in Africa in 2010: a modelling study. (25103519)
2014
8
Exploring putative molecular mechanisms of human pyruvate kinase enzyme deficiency and its role in resistance against Plasmodium falciparum malaria. (25172454)
2014
9
Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. (23645841)
2013
10
Safety and immunogenicity of heterologous prime-boost immunisation with Plasmodium falciparum malaria candidate vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in healthy Gambian and Kenyan adults. (23526949)
2013
11
Therapeutic efficacy of fixed dose artesunate-mefloquine for the treatment of acute, uncomplicated Plasmodium falciparum malaria in Kampong Speu, Cambodia. (24060207)
2013
12
Zinc, copper and C-reactive protein in children with severe Plasmodium falciparum malaria in an area of unstable malaria transmission in eastern Sudan. (23104565)
2013
13
Comparative evaluation of efficacy and safety of artesunate-lumefantrine vs. artemether-lumefantrine fixed-dose combination in the treatment of uncomplicated Plasmodium falciparum malaria. (23489465)
2013
14
Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. (22665809)
2012
15
Large-scale growth of the Plasmodium falciparum malaria parasite in a wave bioreactor. (22326740)
2012
16
Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria. (23071567)
2012
17
Antigen-specific B memory cell responses to Plasmodium falciparum malaria antigens and Schistosoma haematobium antigens in co-infected Malian children. (22693628)
2012
18
Iron deficiency and severe Plasmodium falciparum malaria. (22354918)
2012
19
Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial. (23113947)
2012
20
Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique. (23295747)
2012
21
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. (21689454)
2011
22
Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum Malaria. (21459194)
2011
23
Symmetrical peripheral gangrene and neurological manifestations in Plasmodium falciparum malaria. (22315752)
2011
24
In vivo efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in Central Ethiopia. (21798054)
2011
25
Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy. (20105282)
2010
26
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
27
Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria. (19946607)
2010
28
The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis. (20098724)
2010
29
Dose-dependent risk of neutropenia after 7-day courses of artesunate monotherapy in Cambodian patients with acute Plasmodium falciparum malaria. (21070142)
2010
30
Plasmodium falciparum malaria detected by HRP-2 antigenemia before microscopic- and PCR-positive conversion. (20421630)
2010
31
Artemisinin derivatives for treatment of uncomplicated Plasmodium falciparum malaria in Sudan: too early for too much hope. (20012990)
2010
32
Dihydroartemisinin-piperaquine versus artemether-lumefantrine, in the treatment of uncomplicated Plasmodium falciparum malaria in central Sudan. (20659392)
2010
33
Endoglin in African children with Plasmodium falciparum malaria: a novel player in severe malaria pathogenesis? (19919302)
2009
34
Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. (19138388)
2009
35
Intrarectal quinine versus intravenous or intramuscular quinine for treating Plasmodium falciparum malaria. (19160229)
2009
36
Activities of artesunate and amodiaquine against intestinal helminth in children with Plasmodium falciparum malaria in endemic areas. (18266013)
2008
37
Taste-masked quinine sulphate pellets: bio-availability in adults and steady-state plasma concentrations in children with uncomplicated Plasmodium falciparum malaria. (18510819)
2008
38
Gametocyte clearance in uncomplicated and severe Plasmodium falciparum malaria after artesunate-mefloquine treatment in Thailand. (18552540)
2008
39
Plasmodium falciparum malaria and atovaquone-proguanil treatment failure. (18258131)
2008
40
Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand. (18180343)
2008
41
Febrile Plasmodium falciparum malaria 4 years after exposure in a man with sickle cell disease. (18616395)
2008
42
Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria. (17325227)
2007
43
Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children. (16766006)
2006
44
Therapeutic efficacy of sulfadoxin/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Enseno, Meskan Woreda, Gurage zone, SNNPR, Ethiopia. (17447375)
2006
45
Plasmodium falciparum malaria in Jamaica, October-December 2006. (17213567)
2006
46
Suppression of RANTES in children with Plasmodium falciparum malaria. (17018392)
2006
47
An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos). (16903879)
2006
48
Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria? (16002039)
2005
49
Plasmodium falciparum malaria: its effects on some haematological parameters in normal and sickle cell Nigerian children. (7899791)
1994
50
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. (1978068)
1990

Variations for Plasmodium Falciparum Malaria

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Expression for genes affiliated with Plasmodium Falciparum Malaria

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Search GEO for disease gene expression data for Plasmodium Falciparum Malaria.

Pathways for genes affiliated with Plasmodium Falciparum Malaria

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Pathways related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4G6PD, SULT1A3

Compounds for genes affiliated with Plasmodium Falciparum Malaria

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Sources:
45Novoseek, 51PharmGKB, 13DrugBank, 30IUPHAR, 3BitterDB, 26HMDB
See all sources

Compounds related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate4510.0G6PD, HP
2thiobarbituric acid4510.0G6PD, HP
3sulfadoxine/pyrimethamine4510.0DHFR, G6PD
4fansidar4510.0DHFR, G6PD
5sulfadoxine51 4511.0G6PD, DHFR
6atovaquone45 1311.0DHFR, G6PD
7zinc protoporphyrin4510.0HP, G6PD
8halofantrine45 1311.0G6PD, DHFR
9artesunate45 5111.0DHFR, G6PD
10pyrimethamine30 51 45 1313.0G6PD, DHFR
11hind iii4510.0SULT1A3, HP
12amodiaquine45 51 1312.0DHFR, G6PD
13mefloquine45 51 1312.0G6PD, DHFR
14trimethoprim51 45 1312.0G6PD, DHFR
15pentamidine45 1310.9DHFR, G6PD
16tocopherol459.9HP, G6PD
17prpp459.9DHFR, G6PD
18sulfamethoxazole51 45 1311.9G6PD, DHFR
19starch459.9G6PD, HP
20sulfonamide459.9DHFR, G6PD
21cellulose acetate459.9HP, G6PD
22dapsone45 3 51 1312.9DHFR, G6PD
23sulfasalazine30 45 51 1312.8HP, G6PD
24lactose45 1310.7G6PD, DHFR, HP
25chloroquine45 3 51 30 1313.7HP, DHFR, G6PD
26vitamin b12459.6HP, G6PD
27phospholipid459.5FABP3, HP, SLC4A1
28ascorbic acid45 2610.5HP, DHFR, G6PD
29vitamin-e459.5HP, G6PD, SULT1A3
30salicylic acid45 3010.5SLC4A1, G6PD, SULT1A3
31hypoxanthine45 26 1311.5G6PD, DHFR
32aspirin45 51 30 2612.5HP, G6PD, SULT1A3
33phenol45 2610.4G6PD, SULT1A3
34epinephrine45 26 1311.4SULT1A3, G6PD, HP
35folate459.4SLC4A1, HP, DHFR, G6PD
36ribavirin45 51 1311.3HP, G6PD
37norepinephrine45 26 1311.3NPPC, FABP3, SULT1A3
38fibrinogen459.3HP, CHIT1, SULT1A3
39cholesterol45 30 26 1312.2SULT1A3, FABP3, HP, SLC4A1
40adenylate459.2G6PD, DHFR, HP, NPPC
41nitric oxide45 26 1311.2SLC4A1, NPPC, HP, SULT1A3
42aspartate459.1HP, DHFR, G6PD, SULT1A3
43cysteine459.0DHFR, HP, NPPC, SLC4A1
44estrogen459.0SULT1A3, G6PD, DHFR, HP
45citrate459.0SLC4A1, HP, DHFR, FABP3, G6PD
46lactate459.0G6PD, FABP3, DHFR, HP, SLC4A1
47atp45 309.9SLC4A1, NPPC, HP, G6PD
48glucose458.8G6PD, FABP3, HP, NPPC, SLC4A1
49creatinine458.7SULT1A3, G6PD, FABP3, HP, NPPC
50lipid457.7SULT1A3, G6PD, CHIT1, FABP3, HP, NPPC

GO Terms for genes affiliated with Plasmodium Falciparum Malaria

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Biological processes related to Plasmodium Falciparum Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to ethanolGO:00454719.5NPPC, G6PD

Products for genes affiliated with Plasmodium Falciparum Malaria

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Sources for Plasmodium Falciparum Malaria

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet