MCID: PLM014
MIFTS: 62

Pleomorphic Adenoma malady

Endocrine diseases, Cancer diseases categories

Summaries for Pleomorphic Adenoma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation... more...

MalaCards: Pleomorphic Adenoma, also known as mixed tumor of the salivary gland, is related to adenoma and pleomorphic adenoma carcinoma. An important gene associated with Pleomorphic Adenoma is DENR (density-regulated protein), and among its related pathways are Pathways in cancer and HTLV-I infection. The compounds cisplatin and doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include the salivary gl, salivary gland and breast, and related mouse phenotypes are growth/size and reproductive system.

Disease Ontology:8 A gastrointestinal benign neoplasm that is a located in the salivary glands.

Description from OMIM:46 181030

Aliases & Classifications for Pleomorphic Adenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

pleomorphic adenoma 8 10
mixed tumor of the salivary gland 8
mixed salivary gland tumor 60
adenoma pleomorphic 44


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Disease Ontology8 DOID:452
MeSH34 D008949
SNOMED-CT56 8360001
OMIM46 181030

Related Diseases for Pleomorphic Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Pleomorphic Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma32.1TP63, SERPINB5, CCND1, CCNA2, HMGA2, PLAG1
2pleomorphic adenoma carcinoma31.7PDZD11
3adenocarcinoma30.9TP53, TP63, SERPINB5, CCND1, CCNA2, XIAP
4adenoid cystic carcinoma30.9TP63, ERBB2, CCND1, S100B, SERPINB5
5myoepithelioma30.9TP63, GFAP, S100B, SERPINB5
6squamous cell carcinoma30.5HMGA2, TP53, TP63, XIAP, CCND1, CCNA2
7melanoma30.2TP53, TP63, SERPINB5, CDKN2A, XIAP, S100B
8chordoma30.2S100B, GFAP
9lipoma30.2PLAG1, HMGA2
10basal cell carcinoma30.2TP63, CTNNB1, TP53
11retinoblastoma30.0CDKN2A, CCND1, GFAP, ERBB2, TP53, CCNA2
12laryngeal squamous cell carcinoma30.0CDKN2A, CCNA2, TP53, TP63, CCND1
13astrocytoma30.0CCNA2, S100B, MAGEA3, CDKN2A, GFAP, TP53
14sarcoma30.0S100B, SERPINB5, HMGA2, CCNA2, TP53, MAGEA3
15adenomas, salivary gland pleomorphic30.0S100B, HMGA2, PLAG1
16liposarcoma30.0TP53, PLAG1, HMGA2
17lung cancer30.0TP63, TP53, CCNA2, ERBB2, XIAP
18breast cancer30.0SERPINB5, CCND1, CTNNB1, ERBB2
19parathyroid adenoma30.0CCND1
20pleomorphic carcinoma11.1
21adenoiditis10.6
22mucoepidermoid carcinoma10.5
23breast adenoma10.5
24lung adenoma10.5
25nasopharyngitis10.4
26in situ carcinoma10.4
27clear cell adenoma10.4
28syringoma10.3
29epithelial-myoepithelial carcinoma10.3
30mixed lacrimal gland cancer10.2
31adenocarcinoma in situ10.2
32pleomorphic lipoma10.2
33bronchus adenoma10.2
34fasciitis10.2
35lacrimal gland adenocarcinoma10.2
36otitis media10.2
37renal adenoma10.2
38thyroiditis10.2
39sebaceous adenoma10.0
40neuroendocrine carcinoma10.0
41bilateral retinoblastoma10.0
42cystic basal cell carcinoma10.0
43parotid gland cancer10.0
44pleomorphic liposarcoma10.0
45small cell carcinoma10.0
46exophthalmos10.0
47fibrillary astrocytoma10.0
48orbit lymphoma10.0
49pregnancy adenoma10.0
50sialadenitis10.0

Graphical network of the top 20 diseases related to Pleomorphic Adenoma:



Diseases related to pleomorphic adenoma

Clinical Features for Pleomorphic Adenoma

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46OMIM
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Clinical features from OMIM:

181030

Drugs & Therapeutics for Pleomorphic Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pleomorphic Adenoma

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Adenoma

Search NIH Clinical Center for Pleomorphic Adenoma

Search CenterWatch for Pleomorphic Adenoma

Genetic Tests for Pleomorphic Adenoma

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Anatomical Context for Pleomorphic Adenoma

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Pleomorphic Adenoma:

32
Salivary gland, Breast, Trachea, Bone, Tongue, Lung, Smooth muscle, Thyroid, Kidney, Skin, Lymph node, Testis, Testes

FMA organs/tissues related to Pleomorphic Adenoma:

14
The salivary gl

Animal Models for Pleomorphic Adenoma or affiliated genes

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36MGI
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Publications for Pleomorphic Adenoma

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50PubMed
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Articles related to Pleomorphic Adenoma:

(show top 50)    (show all 637)
idTitleAuthorsYear
1
Pleomorphic adenoma of the trachea: a case report. (24419187)
2014
2
Lacrimal gland pleomorphic adenoma masquerading as thyroid-associated ophthalmopathy. (23514669)
2013
3
Clinical characteristics of pleomorphic adenoma of salivary glands among Jordanian patients. (23914638)
2013
4
Immunohistochemical expression of metallothionein in pleomorphic adenoma of minor salivary glands: a role in the control of apoptosis? (23332881)
2013
5
Pleomorphic adenoma of the palate: a case report and review of the literature. (23788973)
2013
6
Carcinoma ex pleomorphic adenoma of the upper lip: a case of an unusual malignant component of squamous cell carcinoma. (24044722)
2013
7
Podoplanin is a novel myoepithelial cell marker in pleomorphic adenoma and other salivary gland tumors with myoepithelial differentiation. (23262786)
2013
8
The increased PDGF-A, PDGF-B and FGF-2 expression in recurrence of salivary gland pleomorphic adenoma. (22174424)
2012
9
Immunohistochemical expression of progesterone receptors in pleomorphic adenoma and adenoid cystic carcinoma. (21546738)
2011
10
Intrasellar salivary gland-like pleomorphic adenoma: case report. (21135727)
2011
11
S100P expression in ductal type of carcinoma ex pleomorphic adenoma. (21317706)
2011
12
Recurrent pleomorphic adenoma: results of surgical treatment. (20645014)
2010
13
Oral and maxillofacial pathology case of the month. Pleomorphic adenoma (benign mixed tumor). (20549995)
2010
14
Parapharyngeal space pleomorphic adenoma: a 30-year review. (19824044)
2009
15
Pleomorphic adenoma of the lateral nasal wall--a case report. (19767912)
2009
16
Expression patterns and prognostic significance of inhibitor of apoptosis proteins in adenoid cystic carcinoma and pleomorphic adenoma of lachrymal gland. (18955046)
2009
17
Pleomorphic adenoma of the cheek: a case report and review. (19531432)
2009
18
Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. (18369704)
2008
19
Jacques-Louis David's tumour: an opportunity to study the natural history of a pleomorphic adenoma of the parotid gland. (19092027)
2008
20
A rare case of primary pleomorphic adenoma in main bronchus. (18721613)
2008
21
Tumoral mass presenting in the nasomalar region arising from the lateral nasal wall: pleomorphic adenoma. (17549505)
2007
22
Epithelial myoepithelial carcinoma of the parotid gland with malignant ductal and myoepithelial components arising in a pleomorphic adenoma: a case report with cytologic, histologic and immunohistochemical correlation. (17910353)
2007
23
Pleomorphic adenoma of the breast should be excised with a cuff of normal tissue. (17593049)
2007
24
Diagnosis of pleomorphic adenoma in a heterotopic salivary gland: a case report. (17425202)
2007
25
Endoscopic surgical treatment of pleomorphic adenoma of the inferior nasal turbinate. (17711754)
2007
26
Carcinoma ex pleomorphic adenoma of the salivary gland: an immunohistochemical study. (17310348)
2007
27
Pleomorphic adenoma of the submandibular gland: an evolving change in practice following review of a personal case series. (17611765)
2007
28
Polarizing light microscopy for identifying chondroid tissue in aspirates of pleomorphic adenoma. (17536564)
2007
29
Lipomatous pleomorphic adenoma of the ceruminous gland. (16398681)
2006
30
Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma. (16757205)
2006
31
Tyrosine crystals in pleomorphic adenoma. (16680769)
2006
32
Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study. (16648762)
2006
33
Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature. (15991841)
2005
34
Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation. (16273189)
2005
35
Pleomorphic adenoma of the accessory parotid gland. (15971746)
2005
36
Pleomorphic adenoma of the breast. (16297122)
2005
37
Immunohistochemical evaluation of p27 (kip1) in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands. (16436005)
2005
38
The expression of matrix metalloproteinases and their tissue inhibitors in pleomorphic adenoma]. (15774155)
2005
39
Tumoral stroma of salivary pleomorphic adenoma -- histopathological, histochemical and immunohistochemical study. (16444308)
2005
40
Pleomorphic adenoma of the nasal cavity: clinical analysis of 8 cases. (15858782)
2005
41
Unusual progression of pleomorphic adenoma of the lacrimal gland: case report. (16127259)
2005
42
The effects of HSV-tk suicide gene and wild-type p53 gene on pleomorphic adenoma cells of salivary gland]. (15804027)
2005
43
Benign metastasizing pleomorphic adenoma of the parotid gland: a clinicopathologic puzzle. (14648866)
2003
44
Pleomorphic adenoma in nasal cavity: immunohistochemical study of three cases. (12167454)
2002
45
Proliferative activity in recurrent and nonrecurrent pleomorphic adenoma of the salivary glands]. (10226990)
1999
46
A case of pleomorphic adenoma of the lung with multiple distant metastases--observations on its oncogene and tumor suppressor gene expression. (9677459)
1998
47
Cell kinetics of pleomorphic adenomas of the parotid gland. (8762871)
1996
48
Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). (7907371)
1993
49
Glial fibrillary acidic protein expression in pleomorphic adenoma, chordoma, and astrocytoma. A comparison of three antibodies. (1654872)
1991
50
Cytokeratins, smooth muscle actin and vimentin in human normal salivary gland and pleomorphic adenomas. Immunohistochemical studies with particular reference to myoepithelial and basal cells. (1710474)
1991

Genetic Variations for Pleomorphic Adenoma

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Expression for genes affiliated with Pleomorphic Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleomorphic Adenoma

Search GEO for disease gene expression data for Pleomorphic Adenoma.

Pathways for genes affiliated with Pleomorphic Adenoma

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Sources:
29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 55SinoBiological, 12EMD Millipore, 51QIAGEN, 53Reactome, 59Tocris Bioscience
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Pathways related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5CCND1, XIAP, CTNNB1, CDKN2A, ERBB2, TP53
210.5CCND1, XIAP, CTNNB1, CDKN2A, TP53
310.5TP53, ERBB2, CTNNB1, CCNA2, CCND1
4
Hide members
10.5CCND1, CTNNB1, CDKN2A, ERBB2, TP53
510.5TP53, TP63, SERPINB5, ERBB2, HMGA2, CDKN2A
6
Hide members
10.5CCND1, XIAP, CTNNB1, ERBB2
7
Hide members
10.5CCND1, CCNA2, CDKN2A, TP63
810.5TP53, ERBB2, CTNNB1, XIAP
9
Hide members
10.5XIAP, CTNNB1, ERBB2, TP53
1010.5CCND1, CCNA2, CDKN2A, TP53
11
Hide members
10.5CCND1, CCNA2, CDKN2A, TP53
12
Hide members
10.5CCND1, CDKN2A, ERBB2, TP53
1310.5TP53, CDKN2A, CTNNB1, CCND1
14
Hide members
10.5CCND1, CTNNB1, ERBB2, TP53
1510.5TP53, ERBB2, CTNNB1, CCND1
16
Hide members
10.5CCNA2, CDKN2A, TP53
17
Transcription Androgen Receptor nuclear signaling
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10.5ERBB2, CTNNB1, CCND1
18
Transcription P53 signaling pathway
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10.5CTNNB1, CDKN2A, TP53
1910.5TP53, XIAP, CCND1
20
Hide members
10.5TP53, ERBB2, GDF5, CCNA2
2110.5TP53, TP63, CDKN2A
2210.5TP53, CCNA2, CCND1
2310.5CCND1, CCNA2, TP53
24
Hide members
10.5CCND1, CDKN2A, SERPINB5, TP53
2510.5TP53, CTNNB1, CCND1
26
Hide members
10.5CCND1, GDF5, GFAP, ERBB2, TP53
2710.5CCND1, CCNA2, SERPINB5
28
Hide members
10.5TP53, ERBB2
29
Hide members
10.5TP53, TP63
30
Hide members
10.5TP53

Compounds for genes affiliated with Pleomorphic Adenoma

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1cisplatin44 49 59 1114.0CCND1, CCNA2, XIAP, CTNNB1, CDKN2A, HMGA2
2doxorubicin44 49 1113.0CCND1, CCNA2, XIAP, CTNNB1, CDKN2A, HMGA2
3vegf4411.0CTNNB1, S100B, XIAP, CCNA2, CCND1, CDKN2A
4paclitaxel44 49 1113.0CCND1, CCNA2, XIAP, S100B, CTNNB1, CDKN2A
5paraffin4411.0TP63, CCNA2, XIAP, S100B, CTNNB1, MAGEA3
6progesterone44 59 28 11 2415.0CCND1, CCNA2, S100B, CTNNB1, CDKN2A, GFAP
7roscovitine4411.0CCND1, CCNA2, XIAP, CTNNB1, CDKN2A, TP53
8retinoic acid44 2411.9CCND1, CCNA2, XIAP, S100B, CTNNB1, CDKN2A
9flavopiridol44 1111.9CCND1, CCNA2, XIAP, CDKN2A, ERBB2, TP53
10testosterone44 59 11 2413.9CCND1, CCNA2, CA3, S100B, CTNNB1, CDKN2A
11depsipeptide4410.9CCND1, CCNA2, CDKN2A, SERPINB5, TP53
12mg 13244 5911.9CCND1, CCNA2, XIAP, CTNNB1, CDKN2A, TP53
13adriamycin4410.9CCND1, XIAP, CTNNB1, CDKN2A
145fluorouracil4410.9CCNA2, XIAP, CTNNB1, CDKN2A, ERBB2, TP53
15bromodeoxyuridine4410.9CCND1, CCNA2, S100B, CTNNB1, GFAP, TP63
16arsenite44 2411.9CCND1, CCNA2, XIAP, CDKN2A, TP53
17estrogen4410.9GFAP
18resveratrol44 59 11 2413.9ERBB2
19agar4410.9CCND1, XIAP, CTNNB1, CDKN2A, GFAP, ERBB2
20olomoucine44 1111.9CCND1, CCNA2, CDKN2A, TP53
21butyrate4410.9GFAP
22adpribose4410.9TP53, CTNNB1, XIAP, CCNA2, CCND1
23steroid4410.9CCND1, CCNA2, CDKN2A, ERBB2, SERPINB5
24gemcitabine44 49 1112.9CCND1, CCNA2, XIAP, ERBB2, TP53
25lovastatin44 49 59 28 1114.9CCND1, CCNA2, XIAP, CTNNB1, CDKN2A
26oligonucleotide4410.9CCND1, CCNA2, XIAP, CTNNB1, MAGEA3, CDKN2A
27cytarabine44 49 1112.9CCNA2, XIAP, CDKN2A, GFAP, TP53
28crcs4410.9TP53, CDKN2A, CTNNB1, CCND1
29thymidylate4410.8TP53, ERBB2, CDKN2A, CCNA2, CCND1
30vincristine44 49 1112.8CCND1, CCNA2, XIAP
31arginine4410.8CCNA2, S100B, CTNNB1, CDKN2A, GFAP, ERBB2
32thymidine44 2411.8CCND1, CCNA2, S100B, CTNNB1, GFAP, TP63
33aspartate4410.8CCNA2, CA3, S100B, CTNNB1, CDKN2A, GFAP
34tamoxifen44 49 28 1113.8CCND1, CCNA2, CTNNB1, ERBB2, SERPINB5, TP53
35docetaxel44 49 59 1113.8CCNA2, XIAP, CDKN2A, ERBB2, TP53
36indole-3-carbinol4410.8CCND1, XIAP, CTNNB1, TP53
37sulindac44 1111.8CCND1, XIAP, CTNNB1, TP53
38dutp4410.8CCND1, XIAP, GFAP, TP53
39serine4410.8CCND1, CCNA2, S100B, GFAP, ERBB2
40suberoylanilide hydroxamic acid4410.7TP53, ERBB2, XIAP, CCND1
41ly2940024410.7CCND1, CCNA2, XIAP, CTNNB1, ERBB2, TP53
42imatinib44 49 1112.7CCND1, XIAP, S100B, CTNNB1, ERBB2
43oxaliplatin44 49 1112.7CCNA2, XIAP, ERBB2, TP53
44curcumin4410.7TP53, ERBB2, CTNNB1, XIAP, CCND1
45hematoxylin4410.6S100B, CDKN2A, GFAP, TP63
46genistein44 28 59 2 11 2415.6ERBB2, GFAP, CDKN2A, CTNNB1, CCNA2, CCND1
47celecoxib44 59 28 49 11 2415.5ERBB2, CTNNB1, CCNA2, CCND1
48hpvs4410.5CCNA2, CDKN2A, TP53
494-hydroxytamoxifen4410.4ERBB2, CTNNB1, S100B, CCND1
50dexamethasone44 49 28 1113.2CCNA2, XIAP, S100B, CTNNB1, CDKN2A, GFAP

GO Terms for genes affiliated with Pleomorphic Adenoma

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16Gene Ontology
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Cellular components related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1senescence-associated heterochromatin focusGO:03598510.6HMGA2, CDKN2A
2nucleusGO:00563410.5CCND1, CCNA2, XIAP, S100B, CTNNB1, CDKN2A
3nucleoplasmGO:00565410.5CCNA2, CTNNB1, CDKN2A, TP63, TP53, CCND1
4cytosolGO:00582910.4CCND1, CA3, XIAP, PDZD11, CTNNB1, CDKN2A
5protein-DNA complexGO:03299310.2HMGA2, CTNNB1

Biological processes related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.8TP53, TP63, CCND1
2positive regulation of cell cycle arrestGO:07115810.8TP53, HMGA2, CDKN2A
3positive regulation of transcription, DNA-dependentGO:04589310.7CCNA2, CTNNB1, CDKN2A, HMGA2, TP63, TP53
4response to X-rayGO:01016510.7CCND1, TP63, TP53
5senescence-associated heterochromatin focus assemblyGO:03598610.7HMGA2, CDKN2A
6embryonic limb morphogenesisGO:03032610.7CTNNB1, GDF5, TP63
7positive regulation of cellular senescenceGO:200077410.7CDKN2A, HMGA2
8negative regulation of immature T cell proliferation in thymusGO:03308810.6CDKN2A, ERBB2
9negative regulation of transcription, DNA-dependentGO:04589210.6CTNNB1, CDKN2A, HMGA2, TP63, TP53
10mitotic G2 DNA damage checkpointGO:00709510.6HMGA2, CCNA2
11Ras protein signal transductionGO:00726510.5CCNA2, CDKN2A, TP53
12DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.5TP53, TP63
13positive regulation of apoptotic processGO:04306510.4TP53, HMGA2, CTNNB1, S100B
14replicative senescenceGO:09039910.2TP53, CDKN2A

Molecular functions related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.6TP53, CCND1, CCNA2, XIAP, S100B, PDZD11
2RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:00107710.5PLAGL2, HMGA2, TP63, TP53
3protein kinase bindingGO:01990110.5TP53, CDKN2A, CTNNB1, CCNA2, CCND1
4transcription factor bindingGO:00813410.5TP53, HMGA2, CDKN2A, CTNNB1
5MDM2/MDM4 family protein bindingGO:09737110.4CDKN2A, TP53
6p53 bindingGO:00203910.2TP53, TP63, CDKN2A

Products for genes affiliated with Pleomorphic Adenoma

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Sources for Pleomorphic Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet