MCID: PLM014
MIFTS: 62

Pleomorphic Adenoma malady

Endocrine diseases, Cancer diseases categories

Summaries for Pleomorphic Adenoma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation... more...

MalaCards: Pleomorphic Adenoma, also known as mixed tumor of the salivary gland, is related to adenoma and pleomorphic adenoma carcinoma. An important gene associated with Pleomorphic Adenoma is DENR (density-regulated protein), and among its related pathways are Pathways in cancer and HTLV-I infection. The compounds cisplatin and doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include the salivary gl, salivary gland and breast, and related mouse phenotypes are growth/size and reproductive system.

Disease Ontology:8 A gastrointestinal benign neoplasm that is a located in the salivary glands.

Description from OMIM:46 181030

Aliases & Classifications for Pleomorphic Adenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

pleomorphic adenoma 8 10
mixed tumor of the salivary gland 8
mixed salivary gland tumor 60
adenoma pleomorphic 44


External Ids:

Disease Ontology8 DOID:452
MeSH34 D008949
SNOMED-CT56 8360001
OMIM46 181030

Related Diseases for Pleomorphic Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Pleomorphic Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma32.1TP63, SERPINB5, CCND1, CCNA2, HMGA2, PLAG1
2pleomorphic adenoma carcinoma31.7PDZD11
3adenocarcinoma30.9TP53, TP63, SERPINB5, CCND1, CCNA2, XIAP
4adenoid cystic carcinoma30.9TP63, ERBB2, CCND1, S100B, SERPINB5
5myoepithelioma30.9TP63, GFAP, S100B, SERPINB5
6squamous cell carcinoma30.5HMGA2, TP53, TP63, XIAP, CCND1, CCNA2
7melanoma30.2TP53, TP63, SERPINB5, CDKN2A, XIAP, S100B
8chordoma30.2S100B, GFAP
9lipoma30.2PLAG1, HMGA2
10basal cell carcinoma30.2TP63, CTNNB1, TP53
11retinoblastoma30.0CDKN2A, CCND1, GFAP, ERBB2, TP53, CCNA2
12laryngeal squamous cell carcinoma30.0CDKN2A, CCNA2, TP53, TP63, CCND1
13astrocytoma30.0CCNA2, S100B, MAGEA3, CDKN2A, GFAP, TP53
14sarcoma30.0S100B, SERPINB5, HMGA2, CCNA2, TP53, MAGEA3
15adenomas, salivary gland pleomorphic30.0S100B, HMGA2, PLAG1
16liposarcoma30.0TP53, PLAG1, HMGA2
17lung cancer30.0TP63, TP53, CCNA2, ERBB2, XIAP
18breast cancer30.0SERPINB5, CCND1, CTNNB1, ERBB2
19parathyroid adenoma30.0CCND1
20pleomorphic carcinoma11.1
21adenoiditis10.6
22mucoepidermoid carcinoma10.5
23breast adenoma10.5
24lung adenoma10.5
25nasopharyngitis10.4
26in situ carcinoma10.4
27clear cell adenoma10.4
28syringoma10.3
29epithelial-myoepithelial carcinoma10.3
30mixed lacrimal gland cancer10.2
31adenocarcinoma in situ10.2
32pleomorphic lipoma10.2
33bronchus adenoma10.2
34fasciitis10.2
35lacrimal gland adenocarcinoma10.2
36otitis media10.2
37renal adenoma10.2
38thyroiditis10.2
39sebaceous adenoma10.0
40neuroendocrine carcinoma10.0
41bilateral retinoblastoma10.0
42cystic basal cell carcinoma10.0
43parotid gland cancer10.0
44pleomorphic liposarcoma10.0
45small cell carcinoma10.0
46exophthalmos10.0
47fibrillary astrocytoma10.0
48orbit lymphoma10.0
49pregnancy adenoma10.0
50sialadenitis10.0

Graphical network of the top 20 diseases related to Pleomorphic Adenoma:



Diseases related to pleomorphic adenoma

Clinical Features for Pleomorphic Adenoma

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46OMIM
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Clinical features from OMIM:

181030

Drugs & Therapeutics for Pleomorphic Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pleomorphic Adenoma

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Adenoma

Search NIH Clinical Center for Pleomorphic Adenoma

Search CenterWatch for Pleomorphic Adenoma

Genetic Tests for Pleomorphic Adenoma

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Anatomical Context for Pleomorphic Adenoma

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Pleomorphic Adenoma:

32
Salivary gland, Breast, Trachea, Bone, Tongue, Lung, Smooth muscle, Thyroid, Kidney, Skin, Lymph node, Testis, Testes

FMA organs/tissues related to Pleomorphic Adenoma:

14
The salivary gl

Animal Models for Pleomorphic Adenoma or affiliated genes

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36MGI
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Publications for Pleomorphic Adenoma

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50PubMed
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Articles related to Pleomorphic Adenoma:

(show top 50)    (show all 637)
idTitleAuthorsYear
1
Differentiation of pleomorphic adenoma and Warthin's tumor of the parotid gland: ultrasonographic features. (24324278)
2013
2
Complete Response to Trastuzumab-Based Chemotherapy in a Patient with Human Epidermal Growth Factor Receptor-2-Positive Metastatic Salivary Duct Carcinoma ex Pleomorphic Adenoma. (24163659)
2013
3
Parapharyngeal pleomorphic adenoma as a cause of severe obstructive sleep apnoea. (24171935)
2013
4
Carcinoma ex pleomorphic adenoma in the oral cavity: a huge oral cavity mass with neck metastasis. (24220462)
2013
5
Conventional MRI findings for predicting submandibular pleomorphic adenoma. (23436825)
2013
6
Is radiotherapy necessary for pleomorphic adenoma? (24290577)
2013
7
Pleomorphic adenoma of the submandibular gland in children: a case report and a review of the Japanese literature. (22082746)
2012
8
Basal cell carcinoma which developed on the surface of recurrent parotid pleomorphic adenoma: coincidence or causality? (22155311)
2012
9
Stepwise regional and distant progression of recurrent pleomorphic adenoma. (21303593)
2011
10
Pleomorphic adenoma of nasal septum: a case report. (20420081)
2010
11
Sustained response of carcinoma ex pleomorphic adenoma treated with trastuzumab and capecitabine. (20504363)
2010
12
Quantitative promoter methylation differentiates carcinoma ex pleomorphic adenoma from pleomorphic salivary adenoma. (21063414)
2010
13
Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma, with emphasis on the carcinoma histologic subtype: a clinicopathologic study of 43 cases. (20338616)
2010
14
Ectomesenchymal chondromyxoid tumor of the tongue masquerading as pleomorphic adenoma on fine needle aspiration cytology smears: a case report. (20306996)
2010
15
Primary pleomorphic adenoma of minor salivary gland in the parapharyngeal space. (19909506)
2009
16
Carcinoma ex pleomorphic adenoma of the buccal region is composed of salivary duct carcinoma and squamous cell carcinoma components. (19467841)
2009
17
CT and MR images of pleomorphic adenoma in major and minor salivary glands. (18093776)
2009
18
Juvenile pleomorphic adenoma of the cheek: a case report and review of literature. (19772659)
2009
19
Expression of hMLH1 and hMSH2 proteins in pleomorphic adenoma of minor salivary glands: relationship with clinical and histologic findings. (19464205)
2009
20
Otalgia due to the pleomorphic adenoma of uvula. (19305261)
2009
21
Pleomorphic adenoma of the lacrimal gland: is there a role for biopsy? (18327162)
2009
22
A case of lipomatous pleomorphic adenoma in the parotid gland: a case report. (19497106)
2009
23
Salivary glands and malignancy in pleomorphic adenoma. (19349500)
2009
24
Pleomorphic adenoma of the nasal columella. (18295980)
2008
25
Management and prognostic factors of recurrent pleomorphic adenoma of the parotid gland: personal experience and review of the literature. (17960409)
2008
26
Isoenzymes of N-acetyl-beta-hexosaminidase in human pleomorphic adenoma and healthy salivary glands: a preliminary study. (18034640)
2008
27
Pleomorphic adenoma of parotid gland: delayed enhancement on computed tomography. (19033432)
2008
28
Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. (17881995)
2007
29
Minute pleomorphic adenoma of the submandibular gland in patients with oral malignancy: a report of two cases with histological and immunohistochemical examination. (17553066)
2007
30
Pulmonary pleomorphic adenoma: report of a rare case. (17616030)
2007
31
Pleomorphic adenoma of the palate in children and adolescents: a report of 2 cases and review of the literature. (17307605)
2007
32
Recurrent pleomorphic adenoma of the parotid gland: analysis of 108 consecutive patients. (17563905)
2007
33
Pleomorphic adenoma in the palpebral lobe of the lacrimal gland misdiagnosed as chalazion. (17613864)
2007
34
Lymphatic vascular density and lymphangiogenesis during tumour progression of carcinoma ex pleomorphic adenoma. (17079351)
2007
35
The immunohistochemical outline of p27kip1, cyclin B1 and cyclin D3 in pleomorphic adenomas. (17146427)
2006
36
Malignant myoepithelioma arising from recurrent pleomorphic adenoma of the soft palate. (15967613)
2005
37
Pleomorphic adenoma of the lacrimal gland in a nine-year-old child. (16402959)
2005
38
Salivary gland-type mixed tumor (pleomorphic adenoma) of the lung. (17670335)
2004
39
Parotid gland cancer: a case report of a primitive adenocarcinoma arising from a multirecurrent pleomorphic adenoma. (15149165)
2004
40
Chronic sialadenitis with pleomorphic adenoma of the parotid: coincidental or causal? (11793066)
2002
41
The myoepithelial immunophenotype in 135 benign and malignant salivary gland tumors other than pleomorphic adenoma. (10458827)
1999
42
Malignant plasmacytoid myoepithelioma of the palate: histological observations compared to benign predominant plasmacytoid myoepithelial cells in pleomorphic adenoma of the palate. (9615385)
1998
43
Immunohistochemical localization of fibroblast growth factor-1 (FGF-1), FGF-2 and fibroblast growth factor receptor-1 (FGFR-1) in pleomorphic adenoma of the salivary glands. (9021547)
1997
44
Salivary epithelial-myoepithelial carcinoma: report of a case misinterpreted as pleomorphic adenoma on fine needle aspiration (FNA). (9202896)
1997
45
Carcinoma ex pleomorphic adenoma of the palate--a case report. (9142663)
1997
46
Immunomorphological characteristics of pleomorphic adenoma of salivary glands. (9203744)
1996
47
Polyploidy in pleomorphic adenomas with cytological atypia. (1319765)
1992
48
Immunohistochemical study of monomorphic adenoma (clear cell and basal cell) and pleomorphic adenoma of the parotid gland]. (1897371)
1991
49
Differential diagnosis of pleomorphic adenoma by immunohistochemical means. (1664847)
1991
50
Nodular hidradenoma: an eccrine sweat gland analog of pleomorphic adenomas of salivary gland origin. (2432207)
1987

Genetic Variations for Pleomorphic Adenoma

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Expression for genes affiliated with Pleomorphic Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleomorphic Adenoma

Search GEO for disease gene expression data for Pleomorphic Adenoma.

Pathways for genes affiliated with Pleomorphic Adenoma

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Sources:
29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 55SinoBiological, 12EMD Millipore, 51QIAGEN, 53Reactome, 59Tocris Bioscience
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Pathways related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5CCND1, XIAP, CTNNB1, CDKN2A, ERBB2, TP53
210.5CCND1, XIAP, CTNNB1, CDKN2A, TP53
310.5TP53, ERBB2, CTNNB1, CCNA2, CCND1
4
Hide members
10.5CCND1, CTNNB1, CDKN2A, ERBB2, TP53
510.5TP53, TP63, SERPINB5, ERBB2, HMGA2, CDKN2A
6
Hide members
10.5CCND1, XIAP, CTNNB1, ERBB2
7
Hide members
10.5CCND1, CCNA2, CDKN2A, TP63
810.5TP53, ERBB2, CTNNB1, XIAP
9
Hide members
10.5XIAP, CTNNB1, ERBB2, TP53
1010.5CCND1, CCNA2, CDKN2A, TP53
11
Hide members
10.5CCND1, CCNA2, CDKN2A, TP53
12
Hide members
10.5CCND1, CDKN2A, ERBB2, TP53
1310.5TP53, CDKN2A, CTNNB1, CCND1
14
Hide members
10.5CCND1, CTNNB1, ERBB2, TP53
1510.5TP53, ERBB2, CTNNB1, CCND1
16
Hide members
10.5CCNA2, CDKN2A, TP53
17
Transcription Androgen Receptor nuclear signaling
Hide members
10.5ERBB2, CTNNB1, CCND1
18
Transcription P53 signaling pathway
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10.5CTNNB1, CDKN2A, TP53
1910.5TP53, XIAP, CCND1
20
Hide members
10.5TP53, ERBB2, GDF5, CCNA2
2110.5TP53, TP63, CDKN2A
2210.5TP53, CCNA2, CCND1
2310.5CCND1, CCNA2, TP53
24
Hide members
10.5CCND1, CDKN2A, SERPINB5, TP53
2510.5TP53, CTNNB1, CCND1
26
Hide members
10.5CCND1, GDF5, GFAP, ERBB2, TP53
2710.5CCND1, CCNA2, SERPINB5
28
Hide members
10.5TP53, ERBB2
29
Hide members
10.5TP53, TP63
30
Hide members
10.5TP53

Compounds for genes affiliated with Pleomorphic Adenoma

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Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1cisplatin44 49 59 1114.0ERBB2, SERPINB5, GFAP, HMGA2, CDKN2A, CCNA2
2doxorubicin44 49 1113.0CCNA2, HMGA2, XIAP, CDKN2A, ERBB2, TP63
3vegf4411.0TP53, S100B, CCND1, CCNA2, XIAP, CTNNB1
4paclitaxel44 49 1113.0CCND1, CCNA2, CDKN2A, S100B, XIAP, TP53
5paraffin4411.0MAGEA3, CCNA2, XIAP, S100B, CTNNB1, HMGA2
6progesterone44 59 28 11 2415.0CTNNB1, CCND1, TP53, TP63, SERPINB5, GFAP
7roscovitine4411.0CCND1, CCNA2, XIAP, CDKN2A, TP53, CTNNB1
8retinoic acid44 2411.9CCND1, TP53, TP63, CTNNB1, CCNA2, XIAP
9flavopiridol44 1111.9CCND1, TP53, ERBB2, CDKN2A, XIAP, CCNA2
10testosterone44 59 11 2413.9GFAP, ERBB2, CCND1, CCNA2, S100B, SERPINB5
11depsipeptide4410.9SERPINB5, CDKN2A, CCNA2, CCND1, TP53
12mg 13244 5911.9XIAP, CCND1, CDKN2A, CCNA2, TP53, CTNNB1
13adriamycin4410.9CDKN2A, CCND1, CTNNB1, XIAP
145fluorouracil4410.9CCNA2, XIAP, CTNNB1, CDKN2A, ERBB2, TP53
15bromodeoxyuridine4410.9CTNNB1, TP63, GFAP, S100B, CCNA2, CCND1
16arsenite44 2411.9TP53, CCND1, CCNA2, XIAP, CDKN2A
17estrogen4410.9GFAP
18resveratrol44 59 11 2413.9ERBB2
19agar4410.9XIAP, CTNNB1, CDKN2A, GFAP, ERBB2, CCND1
20olomoucine44 1111.9CCND1, TP53, CDKN2A, CCNA2
21butyrate4410.9GFAP
22adpribose4410.9CCNA2, CCND1, XIAP, CTNNB1, TP53
23steroid4410.9SERPINB5, ERBB2, CDKN2A, CCNA2, CCND1
24gemcitabine44 49 1112.9CCND1, XIAP, CCNA2, ERBB2, TP53
25lovastatin44 49 59 28 1114.9CDKN2A, CTNNB1, XIAP, CCNA2, CCND1
26oligonucleotide4410.9PLAG1, CDKN2A, CTNNB1, XIAP, CCNA2, CCND1
27cytarabine44 49 1112.9CCNA2, XIAP, CDKN2A, GFAP, TP53
28crcs4410.9TP53, CDKN2A, CTNNB1, CCND1
29thymidylate4410.8ERBB2, CDKN2A, TP53, CCNA2, CCND1
30vincristine44 49 1112.8XIAP, CCND1, CCNA2
31arginine4410.8ERBB2, GFAP, TP63, CDKN2A, CTNNB1, S100B
32thymidine44 2411.8GFAP, CTNNB1, CCNA2, CCND1, S100B, TP63
33aspartate4410.8CTNNB1, CDKN2A, ERBB2, GFAP, S100B, CA3
34tamoxifen44 49 28 1113.8TP53, ERBB2, CCND1, CTNNB1, CCNA2, SERPINB5
35docetaxel44 49 59 1113.8ERBB2, CDKN2A, TP53, XIAP, CCNA2
36indole-3-carbinol4410.8CCND1, TP53, XIAP, CTNNB1
37dutp4410.8XIAP, GFAP, TP53, CCND1
38sulindac44 1111.8CTNNB1, CCND1, XIAP, TP53
39serine4410.8CCND1, CCNA2, GFAP, S100B, ERBB2
40suberoylanilide hydroxamic acid4410.7ERBB2, TP53, XIAP, CCND1
41ly2940024410.7XIAP, CTNNB1, ERBB2, CCND1, TP53, CCNA2
42imatinib44 49 1112.7CCND1, ERBB2, CTNNB1, S100B, XIAP
43oxaliplatin44 49 1112.7TP53, CCNA2, XIAP, ERBB2
44curcumin4410.7TP53, ERBB2, CTNNB1, XIAP, CCND1
45hematoxylin4410.6TP63, GFAP, CDKN2A, S100B
46genistein44 28 59 2 11 2415.6ERBB2, CTNNB1, CCNA2, CCND1, CDKN2A, GFAP
47celecoxib44 59 28 49 11 2415.5CTNNB1, ERBB2, CCND1, CCNA2
48hpvs4410.5CDKN2A, CCNA2, TP53
494-hydroxytamoxifen4410.4CTNNB1, ERBB2, S100B, CCND1
50dexamethasone44 49 28 1113.2GFAP, S100B, XIAP, CCNA2, CTNNB1, CDKN2A

GO Terms for genes affiliated with Pleomorphic Adenoma

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16Gene Ontology
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Cellular components related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1senescence-associated heterochromatin focusGO:03598510.6HMGA2, CDKN2A
2nucleusGO:00563410.5CCND1, CCNA2, XIAP, S100B, CTNNB1, CDKN2A
3nucleoplasmGO:00565410.5CCNA2, CTNNB1, CDKN2A, TP63, TP53, CCND1
4cytosolGO:00582910.4CCND1, CA3, XIAP, PDZD11, CTNNB1, CDKN2A
5protein-DNA complexGO:03299310.2HMGA2, CTNNB1

Biological processes related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.8TP53, TP63, CCND1
2positive regulation of cell cycle arrestGO:07115810.8TP53, HMGA2, CDKN2A
3positive regulation of transcription, DNA-dependentGO:04589310.7CCNA2, CTNNB1, CDKN2A, HMGA2, TP63, TP53
4response to X-rayGO:01016510.7CCND1, TP63, TP53
5senescence-associated heterochromatin focus assemblyGO:03598610.7HMGA2, CDKN2A
6embryonic limb morphogenesisGO:03032610.7CTNNB1, GDF5, TP63
7positive regulation of cellular senescenceGO:200077410.7CDKN2A, HMGA2
8negative regulation of immature T cell proliferation in thymusGO:03308810.6CDKN2A, ERBB2
9negative regulation of transcription, DNA-dependentGO:04589210.6CTNNB1, CDKN2A, HMGA2, TP63, TP53
10mitotic G2 DNA damage checkpointGO:00709510.6HMGA2, CCNA2
11Ras protein signal transductionGO:00726510.5CCNA2, CDKN2A, TP53
12DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.5TP53, TP63
13positive regulation of apoptotic processGO:04306510.4TP53, HMGA2, CTNNB1, S100B
14replicative senescenceGO:09039910.2TP53, CDKN2A

Molecular functions related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.6TP53, CCND1, CCNA2, XIAP, S100B, PDZD11
2RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:00107710.5PLAGL2, HMGA2, TP63, TP53
3protein kinase bindingGO:01990110.5TP53, CDKN2A, CTNNB1, CCNA2, CCND1
4transcription factor bindingGO:00813410.5TP53, HMGA2, CDKN2A, CTNNB1
5MDM2/MDM4 family protein bindingGO:09737110.4CDKN2A, TP53
6p53 bindingGO:00203910.2TP53, TP63, CDKN2A

Products for genes affiliated with Pleomorphic Adenoma

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Sources for Pleomorphic Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet