MCID: PLM014
MIFTS: 61

Pleomorphic Adenoma malady

Endocrine diseases, Cancer diseases, Oral diseases categories

Summaries for Pleomorphic Adenoma

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Wikipedia:65 Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation... more...

MalaCards based summary: Pleomorphic Adenoma, also known as mixed tumor of the salivary gland, is related to adenoma and myoepithelioma. An important gene associated with Pleomorphic Adenoma is DENR (density-regulated protein), and among its related pathways are IL-2 Gene Expression in Activated and Quiescent T-Cells and Inhibition of Ribosome Biogenesis by p14(ARF). The compounds lovastatin and olomoucine have been mentioned in the context of this disorder. Affiliated tissues include the salivary gl, salivary gland and breast, and related mouse phenotypes are limbs/digits/tail and nervous system.

Disease Ontology:10 A gastrointestinal benign neoplasm that is a located in the salivary glands.

Aliases & Classifications for Pleomorphic Adenoma

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Sources:
10Disease Ontology, 12DISEASES, 62UMLS, 45Novoseek, 35MeSH, 40NCIt, 57SNOMED-CT
See all sources

Pleomorphic Adenoma, Aliases & Descriptions:

Name: Pleomorphic Adenoma 10 12
Mixed Tumor of the Salivary Gland 10 62
 
Mixed Salivary Gland Tumor 62
Adenoma Pleomorphic 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases, Oral diseases


External Ids:

Disease Ontology10 DOID:452
MeSH35 D008949
SNOMED-CT57 8360001

Related Diseases for Pleomorphic Adenoma

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Diseases related to Pleomorphic Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma32.1CD44, CDKN2A, CCND1, TP63, TP53, CTNNB1
2myoepithelioma31.0TP63, S100B
3adenocarcinoma30.8CTNNB1, TP53, CCND1, ERBB2, XIAP, TP63
4chronic lymphocytic leukemia30.2CCND1, CCNA2, XIAP
5breast cancer30.1ERBB2, CCND1, CTNNB1
6melanoma30.1CDKN2A, TP63, TP53, CCNA2, CCND1, S100B
7basal cell carcinoma30.1CTNNB1, TP53, TP63, CD44
8sarcoma30.1TP63, CCNA2, S100B, TP53
9retinoblastoma30.1CDKN2A, ERBB2, CCND1, TP53, CCNA2
10astrocytoma30.1CD44, CDKN2A, TP53, S100B, CCNA2
11leukemia30.0XIAP, CD44, CDKN2A, TP53, CCNA2, CCND1
12lung cancer30.0TP53, CCNA2, ERBB2, XIAP, CD44, TP63
13adenoiditis10.7
14mucoepidermoid carcinoma10.6
15pleomorphic adenoma carcinoma10.6
16nasopharyngitis10.5
17polymorphous low-grade adenocarcinoma10.5
18epithelial-myoepithelial carcinoma10.4
19mixed lacrimal gland cancer10.4
20syringoma10.4
21fasciitis10.3
22thyroiditis10.3
23lipoma10.2
24adenomas, salivary gland pleomorphic10.2
25chordoma10.2
26otitis media10.2
27asthma10.1
28myxoid liposarcoma10.1
29hepatitis10.1
30joint disorders10.1
31neuroendocrine carcinoma10.1
32large cell neuroendocrine carcinoma10.1
33exophthalmos10.1
34keratinizing squamous cell carcinoma10.1
35orbit lymphoma10.1
36sialadenitis10.1
37nodular hidradenoma10.1
38clear cell sarcoma10.1
39chondroid lipoma10.1
40spindle cell lipoma10.1
41bilateral retinoblastoma10.1
42small cell carcinoma10.1
43adenocarcinoma in situ10.1
44cervicitis10.1
45giant cell tumor10.1
46hidradenoma10.1
47in situ carcinoma10.1
48laryngitis10.1
49leiomyomatosis10.1
50liposarcoma10.1

Graphical network of the top 20 diseases related to Pleomorphic Adenoma:



Diseases related to pleomorphic adenoma

Symptoms for Pleomorphic Adenoma

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Drugs & Therapeutics for Pleomorphic Adenoma

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Drug clinical trials:

Search ClinicalTrials for Pleomorphic Adenoma

Search NIH Clinical Center for Pleomorphic Adenoma

Genetic Tests for Pleomorphic Adenoma

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Anatomical Context for Pleomorphic Adenoma

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MalaCards organs/tissues related to Pleomorphic Adenoma:

33
Salivary gland, Breast, Trachea, Bone, Tongue, Lung, Smooth muscle, Kidney, Thyroid, Skin, Lymph node, Testes

FMA organs/tissues related to Pleomorphic Adenoma:

16
The salivary gl

Animal Models for Pleomorphic Adenoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Adenoma:

37 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053717.7TP63, TP53, ERBB2, XIAP, CD44, CTNNB1
2MP:00036317.5CTNNB1, CD44, CDKN2A, ERBB2, CCND1, TP53
3MP:00053807.4TP63, TP53, CCNA2, ERBB2, CDKN2A, CTNNB1
4MP:00053917.4TP63, TP53, CCND1, CDKN2A, CD44, CTNNB1
5MP:00053697.4TP63, TP53, ERBB2, XIAP, CDKN2A, CD44
6MP:00053827.4TP63, TP53, CCND1, ERBB2, CTNNB1
7MP:00053977.3TP53, CCNA2, CCND1, XIAP, CDKN2A, CD44
8MP:00020067.3TP63, TP53, CCND1, ERBB2, CDKN2A, CD44
9MP:00053887.2TP63, TP53, CCND1, ERBB2, CDKN2A, CD44
10MP:00053817.2TP63, TP53, CCND1, ERBB2, CDKN2A, CD44
11MP:00053857.1TP63, TP53, CCND1, ERBB2, XIAP, CD44
12MP:00053797.0TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
13MP:00053907.0TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
14MP:00053896.9TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
15MP:00053876.9TP63, TP53, CCNA2, CCND1, XIAP, CDKN2A
16MP:00053786.8TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
17MP:00028736.8TP63, TP53, CCND1, S100B, ERBB2, XIAP
18MP:00053766.7TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
19MP:00053846.6TP63, TP53, CCNA2, CCND1, ERBB2, XIAP
20MP:00107686.5TP63, TP53, CCNA2, CCND1, ERBB2, XIAP
21MP:00107716.5CTNNB1, TP63, TP53, CCND1, S100B, ERBB2
22MP:00053866.4TP63, TP53, CCND1, S100B, ERBB2, XIAP

Publications for Pleomorphic Adenoma

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Articles related to Pleomorphic Adenoma:

(show top 50)    (show all 668)
idTitleAuthorsYear
1
Management of pleomorphic adenoma in the nasopharynx: a case report. (25759784)
2015
2
Cellular senescence and autophagy of myoepithelial cells are involved in the progression of in situ areas of carcinoma ex-pleomorphic adenoma to invasive carcinoma. An in vitro model. (25895748)
2015
3
Salivary duct carcinoma ex pleomorphic adenoma of the palate: a case report. (25579019)
2015
4
MRI criteria for the diagnosis of pleomorphic adenoma: a validation study. (25128908)
2014
5
Nasopharyngeal pleomorphic adenoma presenting as otitis media with effusion: case report and literature review. (24051236)
2014
6
Surgical management of pleomorphic adenoma of parotid gland in elderly patients: Role of morphological features. (25159550)
2014
7
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. (24121173)
2013
8
Lacrimal gland pleomorphic adenoma: an inconceivable diagnosis in a child. (23667244)
2013
9
Salivary gland pleomorphic adenoma with giant cell tumor component. (23349467)
2013
10
Lacrimal gland pleomorphic adenoma masquerading as thyroid-associated ophthalmopathy. (23514669)
2013
11
Imaging findings of parapharyngeal space pleomorphic adenoma in comparison with parotid gland pleomorphic adenoma. (23990367)
2013
12
A rare case of nasopharyngeal pleomorphic adenoma. (23738174)
2013
13
Ectopic pleomorphic adenoma. (22536563)
2012
14
Lacrimal gland pleomorphic adenoma. (22656910)
2012
15
Chromosomal aberrations in minor salivary gland pleomorphic adenoma. (22695012)
2012
16
Pleomorphic adenoma in ectopic salivary gland tissue in the neck. (23397772)
2012
17
Carcinoma ex pleomorphic adenoma of the parotid gland. (22287150)
2012
18
Invasive salivary duct carcinoma ex pleomorphic adenoma of the parotid gland: a teaching case giving rise to the genuine diagnostic difficulty on an inadequate cytology specimen. (22647549)
2012
19
Pleomorphic adenoma of the lower lip: A rare site of location. (22540103)
2011
20
Increased mucin 1 expression in recurrence and malignant transformation of salivary gland pleomorphic adenoma. (21323961)
2011
21
Stepwise regional and distant progression of recurrent pleomorphic adenoma. (21303593)
2011
22
Immunohistochemical expression of progesterone receptors in pleomorphic adenoma and adenoid cystic carcinoma. (21546738)
2011
23
Pleomorphic adenoma of nasal septum: a case report. (20420081)
2010
24
Multicentric recurrent parotid pleomorphic adenoma in a child. (20173712)
2010
25
Pleomorphic adenoma of the main bronchus in an adult treated using a wedge bronchiectomy. (19160012)
2009
26
Primary pleomorphic adenoma of minor salivary gland in the parapharyngeal space. (19909506)
2009
27
Tumoral mass presenting in the nasomalar region arising from the lateral nasal wall: pleomorphic adenoma. (17549505)
2007
28
Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. (17881995)
2007
29
Interesting Case: Maxillary swing approach for resection of a large pleomorphic adenoma arising in the soft palate. (16055235)
2006
30
Pleomorphic adenoma of the nasal septum and its relationship with Epstein-Barr virus. (16895748)
2006
31
Lipomatous pleomorphic adenoma of the ceruminous gland. (16398681)
2006
32
Carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma. (16086968)
2005
33
Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature. (15991841)
2005
34
Pleomorphic adenoma of the breast: case report and review of the literature. (16299746)
2005
35
Loss of heterozygosity occurs predominantly, but not exclusively, in the epithelial compartment of pleomorphic adenoma. (16026648)
2005
36
Salivary gland-type mixed tumor (pleomorphic adenoma) of the lung. (17670335)
2004
37
Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. (12406304)
2002
38
Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas. (11894114)
2002
39
Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. (11431714)
2001
40
Histologic localization of PLAG1 (pleomorphic adenoma gene 1) in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells. (11555676)
2001
41
Pleomorphic adenoma gene 1 is expressed in cultured benign and malignant salivary gland tumor cells. (10334569)
1999
42
Immunohistochemical localization of fibroblast growth factors (FGFs) and FGF receptor-1 in human normal salivary glands and pleomorphic adenomas. (9725564)
1998
43
Immunohistochemical demonstration of bone morphogenetic protein-2 and type II collagen in pleomorphic adenoma of salivary glands. (9725565)
1998
44
Myoepithelial carcinoma with predominance of plasmacytoid cells arising in a pleomorphic adenoma of the parotid gland. (9839176)
1998
45
DNA flow cytometry and glial fibrillary acidic protein reactivity in pleomorphic adenomas of the salivary glands. (8908307)
1996
46
Expression of keratin mRNAs and proteins in normal salivary epithelia and pleomorphic adenomas. (7506306)
1993
47
Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). (7907371)
1993
48
Pleomorphic adenoma (benign mixed tumor) of the trachea. (1329058)
1992
49
Immunohistochemical study of monomorphic adenoma (clear cell and basal cell) and pleomorphic adenoma of the parotid gland]. (1897371)
1991
50
Abundant dendritic cells express HLA-DR in pleomorphic adenomas. (1980169)
1990

Variations for Pleomorphic Adenoma

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Expression for genes affiliated with Pleomorphic Adenoma

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Search GEO for disease gene expression data for Pleomorphic Adenoma.

Pathways for genes affiliated with Pleomorphic Adenoma

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Pathways related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CCNA2, CCND1
29.3CDKN2A, TP53
3
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.3CCNA2, CDKN2A, CCND1
4
Show member pathways
9.1TP53, CCND1
5
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1CCND1, CTNNB1, ERBB2
6
Show member pathways
9.0CCNA2, TP53, CDKN2A
7
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0XIAP, ERBB2, TP53
88.9TP53, CCNA2, CD44
98.9TP53, CDKN2A, CD44
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
8.9XIAP, CTNNB1, TP53
118.9CTNNB1, TP53, CDKN2A
128.8CCND1, TP53, XIAP
13
Show member pathways
8.8TP53, ERBB2, CTNNB1
148.8CCNA2, TP53, CCND1
158.8CCND1, CCNA2, TP53
16
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.8CCNA2, TP53, CCND1
178.8CCNA2, CCND1, TP53
18
Show member pathways
DNA damage response38
8.8CCND1, TP53, CDKN2A
19
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
8.8ERBB2, CCND1, TP53
20
Show member pathways
8.7TP63, TP53, CDKN2A
218.7CTNNB1, CCND1, TP53
228.7TP53, CTNNB1, CCND1
238.7CTNNB1, CCND1, TP53
24
Show member pathways
Wnt Signaling Pathway NetPath38
8.7CTNNB1, CCND1, TP53
258.7CTNNB1, TP53, CCND1
268.7CTNNB1, CCND1, TP53
27
Show member pathways
8.5CD44, CDKN2A, ERBB2, TP53
288.5ERBB2, XIAP, TP53, CTNNB1
29
Show member pathways
8.5TP53, CDKN2A, CCND1, CCNA2
30
Show member pathways
8.5CDKN2A, TP53, CCNA2, CCND1
31
Show member pathways
8.5CDKN2A, CCND1, TP53, CCNA2
328.5CCNA2, CDKN2A, TP53, CCND1
33
Show member pathways
Cell cycle38
8.5CCNA2, CCND1, CDKN2A, TP53
34
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.4CTNNB1, CD44, ERBB2, CCND1, XIAP
35
Show member pathways
8.4ERBB2, CDKN2A, TP53, CCND1
36
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.4TP63, CDKN2A, TP53, XIAP
378.3CDKN2A, TP53, CCND1, CTNNB1
38
Show member pathways
Signal transduction PTEN pathway60
8.3TP53, CCND1, CTNNB1, ERBB2
398.3TP53, CTNNB1, CD44, CCND1
40
Show member pathways
8.1CCND1, CDKN2A, CCNA2, TP53, ERBB2
41
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.1XIAP, CTNNB1, TP53, CCND1, CCNA2
428.0CCND1, TP53, XIAP, CDKN2A, CTNNB1
438.0CCND1, ERBB2, CCNA2, TP53, CTNNB1
44
Show member pathways
8.0CCND1, TP53, CDKN2A, ERBB2, CTNNB1
45
Show member pathways
Signaling Pathways in Glioblastoma38
8.0CTNNB1, CCND1, ERBB2, CDKN2A, TP53
467.9CTNNB1, CD44, ERBB2, TP53, CCND1
47
Show member pathways
7.8CDKN2A, CCND1, CCNA2, TP53, TP63
487.7TP53, CDKN2A, CTNNB1, XIAP, ERBB2, CCND1
49
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
7.5CDKN2A, ERBB2, TP53, CD44, CTNNB1, CCND1
507.4CD44, CDKN2A, CCND1, TP53, ERBB2, TP63

Compounds for genes affiliated with Pleomorphic Adenoma

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Compounds related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1lovastatin45 51 61 30 1312.9CCND1, CTNNB1, CDKN2A, XIAP, CCNA2
2olomoucine45 139.8CCNA2, TP53, CDKN2A, CCND1
3oxaliplatin45 51 1310.8XIAP, ERBB2, TP53, CCNA2
4depsipeptide458.7TP53, CCNA2, CCND1, CDKN2A
5suberoylanilide hydroxamic acid458.7ERBB2, TP53, CCND1, XIAP
6indole-3-carbinol458.7XIAP, CTNNB1, CCND1, TP53
7sulindac45 139.6TP53, CTNNB1, XIAP, CCND1
8crcs458.6TP53, CCND1, CDKN2A, CTNNB1
9docetaxel45 51 61 1311.6TP53, CDKN2A, ERBB2, XIAP, CCNA2
104-hydroxytamoxifen458.6CTNNB1, S100B, CCND1, ERBB2
11agar458.6CCND1, XIAP, CDKN2A, CTNNB1, ERBB2
12imatinib45 51 1310.6XIAP, ERBB2, CTNNB1, CCND1, S100B
13celecoxib45 61 30 51 26 1313.5CTNNB1, CCNA2, CCND1, ERBB2
14gemcitabine45 51 1310.5CCNA2, CCND1, XIAP, ERBB2, TP53
15bortezomib45 51 1310.5TP53, ERBB2, XIAP, CCND1
16thymidylate458.4CDKN2A, TP53, CCNA2, ERBB2, CCND1
17adpribose458.4CCNA2, TP53, CTNNB1, XIAP, CCND1
18curcumin458.2CCND1, TP53, XIAP, CTNNB1, ERBB2
195fluorouracil458.2TP53, CCNA2, ERBB2, XIAP, CDKN2A, CTNNB1
20flavopiridol45 139.2XIAP, TP53, CDKN2A, CCNA2, ERBB2, CCND1
21vincristine45 51 1310.2CD44, XIAP, CCND1, CCNA2, TP53, CDKN2A
22roscovitine458.1CDKN2A, CTNNB1, CCND1, XIAP, TP53, CCNA2
23mg 13245 619.1CDKN2A, TP53, CTNNB1, CCNA2, CCND1, XIAP
24resveratrol45 61 26 1311.1TP53, CCNA2, CTNNB1, XIAP, ERBB2, CCND1
25arsenite45 269.1CDKN2A, XIAP, TP53, CCNA2, CCND1, CTNNB1
26etoposide45 51 61 1311.1XIAP, CD44, ERBB2, TP53, CCNA2, S100B
27egcg458.1TP53, ERBB2, XIAP, CDKN2A, CCND1, CTNNB1
28dexamethasone45 51 30 1311.1XIAP, S100B, ERBB2, CCNA2, CDKN2A, CD44
29bromodeoxyuridine458.0CTNNB1, TP63, CCNA2, S100B, CCND1, CD44
30h2o2457.9XIAP, CTNNB1, ERBB2, CCNA2, TP53, CDKN2A
31tamoxifen45 51 30 1310.9TP53, CCNA2, CCND1, ERBB2, CD44, CTNNB1
32n acetylcysteine457.9CDKN2A, TP53, ERBB2, CCND1, CTNNB1
33butyrate457.7CCNA2, CTNNB1, CDKN2A, XIAP, CD44, TP53
34adriamycin457.7TP53, XIAP, ERBB2, CTNNB1, CD44, CCND1
35ly294002457.7XIAP, TP53, CCNA2, CD44, ERBB2, CCND1
36cycloheximide457.3CDKN2A, CD44, CTNNB1, CCND1, XIAP, ERBB2
37testosterone45 61 26 1310.3CCND1, CCNA2, S100B, TP63, ERBB2, CDKN2A
38steroid457.3TP63, S100B, CDKN2A, CCND1, CD44, CCNA2
39thymidine45 268.2CCND1, CD44, S100B, TP63, CTNNB1, TP53
40tyrosine457.1TP63, CCNA2, CCND1, S100B, CD44, ERBB2
41arginine457.0CTNNB1, CCNA2, TP53, TP63, S100B, ERBB2
42paclitaxel45 51 138.8TP53, CCNA2, CCND1, S100B, ERBB2, XIAP
43serine456.8S100B, ERBB2, XIAP, CDKN2A, CD44, CTNNB1
44doxorubicin45 51 138.8CTNNB1, CD44, CDKN2A, XIAP, CCND1, CCNA2
45cisplatin45 51 61 139.7TP63, TP53, CCNA2, CD44, CTNNB1, ERBB2
46retinoic acid45 267.6TP63, CTNNB1, S100B, CD44, CDKN2A, XIAP
47progesterone45 30 61 26 1310.5TP63, TP53, CCNA2, CCND1, S100B, CDKN2A
48estrogen456.5CTNNB1, TP63, TP53, CCNA2, CCND1, S100B
49paraffin456.2S100B, CCND1, CTNNB1, CCNA2, TP53, TP63
50vegf456.2TP53, CCNA2, CCND1, S100B, ERBB2, XIAP

GO Terms for genes affiliated with Pleomorphic Adenoma

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Cellular components related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.3CDKN2A, TP53
2basolateral plasma membraneGO:00163239.1ERBB2, CD44, CTNNB1
3nucleoplasmGO:00056547.5CTNNB1, CCND1, CCNA2, TP53, TP63, CDKN2A
4cytosolGO:00058297.1TP63, TP53, CCND1, XIAP, CDKN2A, CTNNB1
5cytoplasmGO:00057376.4CDKN2A, CD44, XIAP, ERBB2, S100B, CCNA2
6nucleusGO:00056346.2CTNNB1, TP63, CDKN2A, XIAP, ERBB2, S100B

Biological processes related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of G2/M transition of mitotic cell cycleGO:001038910.2CDKN2A, CCNA2
2negative regulation of immature T cell proliferation in thymusGO:003308810.1CDKN2A, ERBB2
3regulation of angiogenesisGO:00457659.9ERBB2, CTNNB1
4replicative senescenceGO:00903999.7CDKN2A, TP53
5proximal/distal pattern formationGO:00099549.7TP63, CTNNB1
6Wnt signaling pathwayGO:00160559.6XIAP, CD44, CTNNB1
7hair follicle morphogenesisGO:00310699.6TP63, CTNNB1
8positive regulation of cell cycle arrestGO:00711589.6CDKN2A, TP53
9embryonic limb morphogenesisGO:00303269.4CTNNB1, TP63
10DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.4TP53, TP63
11Ras protein signal transductionGO:00072659.4TP53, CCNA2, CDKN2A
12positive regulation of mesenchymal cell proliferationGO:00020539.3TP63, CTNNB1
13cell agingGO:00075699.3TP53, TP63
14T cell differentiation in thymusGO:00330779.3CTNNB1, TP53
15response to gamma radiationGO:00103329.2TP63, TP53
16intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.2TP53, TP63
17cellular response to UVGO:00346449.1TP63, TP53
18cellular response to DNA damage stimulusGO:00069749.1XIAP, CCND1, TP53
19neuron apoptotic processGO:00514029.0TP63, TP53
20mitotic G1 DNA damage checkpointGO:00315718.9CCND1, TP53, TP63
21response to X-rayGO:00101658.9CCND1, TP53, TP63
22Notch signaling pathwayGO:00072198.9CCND1, TP53, TP63
23negative regulation of apoptotic processGO:00430668.7TP63, TP53, XIAP, CD44
24negative regulation of transcription, DNA-templatedGO:00458928.6TP63, TP53, CDKN2A, CTNNB1
25apoptotic processGO:00069158.6TP63, TP53, XIAP, CTNNB1
26positive regulation of transcription from RNA polymerase II promoterGO:00459448.4TP63, TP53, CDKN2A, CTNNB1
27positive regulation of apoptotic processGO:00430658.4CTNNB1, S100B, TP53
28negative regulation of transcription from RNA polymerase II promoterGO:00001228.4TP63, TP53, CCND1, CTNNB1
29positive regulation of transcription, DNA-templatedGO:00458938.3TP63, TP53, CCNA2, CDKN2A, CTNNB1

Molecular functions related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:00973719.4CDKN2A, TP53
2damaged DNA bindingGO:00036849.0TP53, TP63
3protein phosphatase bindingGO:00199038.9CTNNB1, ERBB2, TP53
4p53 bindingGO:00020398.9CDKN2A, TP53, TP63
5transcription factor bindingGO:00081348.5TP53, CCND1, CDKN2A, CTNNB1
6transcription regulatory region DNA bindingGO:00442128.5CTNNB1, TP53, TP63
7enzyme bindingGO:00198998.4TP53, CCND1, CTNNB1
8protein kinase bindingGO:00199018.2TP53, CCNA2, CCND1, CDKN2A, CTNNB1
9identical protein bindingGO:00428028.1TP63, TP53, S100B, ERBB2
10protein bindingGO:00055155.7CTNNB1, DENR, TP63, TP53, CCNA2, CCND1

Products for genes affiliated with Pleomorphic Adenoma

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Sources for Pleomorphic Adenoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet