MCID: PLM014
MIFTS: 53

Pleomorphic Adenoma malady

Endocrine diseases, Cancer diseases, Oral diseases categories

Aliases & Classifications for Pleomorphic Adenoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH, 38NCIt, 55SNOMED-CT
See all sources

Pleomorphic Adenoma, Aliases & Descriptions:

Name: Pleomorphic Adenoma 9 11
Mixed Tumor of the Salivary Gland 9
 
Mixed Salivary Gland Tumor 60
Adenoma Pleomorphic 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases, Oral diseases


External Ids:

Disease Ontology9 DOID:452
MeSH33 D008949
SNOMED-CT55 8360001

Summaries for Pleomorphic Adenoma

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Wikipedia:63 Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation... more...

MalaCards based summary: Pleomorphic Adenoma, also known as mixed tumor of the salivary gland, is related to myoepithelioma and adenoma. An important gene associated with Pleomorphic Adenoma is DENR (density-regulated protein), and among its related pathways are IL-2 Gene Expression in Activated and Quiescent T-Cells and Inhibition of Ribosome Biogenesis by p14(ARF). The compounds lovastatin and olomoucine have been mentioned in the context of this disorder. Affiliated tissues include the salivary gl, salivary gland and breast, and related mouse phenotypes are limbs/digits/tail and nervous system.

Disease Ontology:9 A gastrointestinal benign neoplasm that is a located in the salivary glands.

Related Diseases for Pleomorphic Adenoma

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Diseases related to Pleomorphic Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1myoepithelioma31.2S100B, TP63
2adenoma31.0TP63, TP53, CCNA2, CCND1, CDKN2A, CD44
3chronic lymphocytic leukemia30.3XIAP, CCND1, CCNA2
4breast cancer30.2CTNNB1, ERBB2, CCND1
5basal cell carcinoma29.6CTNNB1, CD44, TP53, TP63
6sarcoma29.6TP63, TP53, CCNA2, S100B
7retinoblastoma29.6TP53, CCNA2, CCND1, ERBB2, CDKN2A
8astrocytoma29.6TP53, CCNA2, S100B, CDKN2A, CD44
9leukemia29.3TP53, CCNA2, CCND1, XIAP, CDKN2A, CD44
10adenocarcinoma29.3TP63, TP53, CCNA2, CCND1, ERBB2, XIAP
11lung cancer29.3TP63, TP53, CCNA2, ERBB2, XIAP, CD44
12melanoma28.6TP63, TP53, CCNA2, CCND1, S100B, XIAP
13adenoiditis10.7
14mucoepidermoid carcinoma10.6
15pleomorphic adenoma carcinoma10.6
16nasopharyngitis10.5
17polymorphous low-grade adenocarcinoma10.5
18epithelial-myoepithelial carcinoma10.4
19mismatch repair cancer syndrome10.4CTNNB1
20gemistocytic astrocytoma10.4S100B
21syringoma10.4
22meningioma, familial10.4S100B
23mixed lacrimal gland cancer10.3
24fasciitis10.3
25thyroiditis10.3
26gallbladder adenoma10.3CDKN2A, CTNNB1
27tonsil squamous cell carcinoma10.3CCND1, CDKN2A
28lipoma10.2
29adenomas, salivary gland pleomorphic10.2
30chordoma10.2
31otitis media10.2
32neuroblastoma10.2TP53
33choroid plexus papilloma10.2TP53
34benign breast phyllodes tumor10.2TP63, CCNA2
35smooth muscle tumor10.2CCNA2, S100B
36ganglioneuroblastoma10.2CD44, S100B
37multiple myeloma10.2CCND1, CD44
38malignant peripheral nerve sheath tumor10.2S100B, CDKN2A
39burkitt lymphoma10.2CD44, XIAP, CCNA2
40breast fibroadenoma10.1TP63, ERBB2
41cervical squamous cell carcinoma10.1TP63, CDKN2A
42ganglioneuroma10.1CD44, S100B
43malignant fibroxanthoma10.1CCNA2, S100B
44oropharynx cancer10.1CDKN2A, TP53
45tongue squamous cell carcinoma10.1CD44, CCND1, CCNA2
46large cell carcinoma10.1ERBB2, TP63
47li-fraumeni syndrome10.1TP53, CDKN2A
48asthma10.1
49myxoid liposarcoma10.1
50hepatitis10.1

Graphical network of the top 20 diseases related to Pleomorphic Adenoma:



Diseases related to pleomorphic adenoma

Symptoms for Pleomorphic Adenoma

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Drugs & Therapeutics for Pleomorphic Adenoma

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Drug clinical trials:

Search ClinicalTrials for Pleomorphic Adenoma

Search NIH Clinical Center for Pleomorphic Adenoma

Genetic Tests for Pleomorphic Adenoma

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Anatomical Context for Pleomorphic Adenoma

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MalaCards organs/tissues related to Pleomorphic Adenoma:

31
Salivary gland, Breast, Trachea, Bone, Tongue, Lung, Smooth muscle, Kidney, Thyroid, Skin, Lymph node, Testes

FMA organs/tissues related to Pleomorphic Adenoma:

14
The salivary gl

Animal Models for Pleomorphic Adenoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Adenoma:

35 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053717.7TP63, TP53, ERBB2, XIAP, CD44, CTNNB1
2MP:00036317.5CTNNB1, CD44, CDKN2A, ERBB2, CCND1, TP53
3MP:00053807.4TP63, TP53, CCNA2, ERBB2, CDKN2A, CTNNB1
4MP:00053917.4TP63, TP53, CCND1, CDKN2A, CD44, CTNNB1
5MP:00053697.4TP63, TP53, ERBB2, XIAP, CDKN2A, CD44
6MP:00053827.4TP63, TP53, CCND1, ERBB2, CTNNB1
7MP:00053977.3TP53, CCNA2, CCND1, XIAP, CDKN2A, CD44
8MP:00020067.3TP63, TP53, CCND1, ERBB2, CDKN2A, CD44
9MP:00053887.2TP63, TP53, CCND1, ERBB2, CDKN2A, CD44
10MP:00053817.2TP63, TP53, CCND1, ERBB2, CDKN2A, CD44
11MP:00053857.1TP63, TP53, CCND1, ERBB2, XIAP, CD44
12MP:00053797.0TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
13MP:00053907.0TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
14MP:00053896.9TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
15MP:00053876.9TP63, TP53, CCNA2, CCND1, XIAP, CDKN2A
16MP:00053786.8TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
17MP:00028736.8TP63, TP53, CCND1, S100B, ERBB2, XIAP
18MP:00053766.7TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
19MP:00053846.6TP63, TP53, CCNA2, CCND1, ERBB2, XIAP
20MP:00107686.5TP63, TP53, CCNA2, CCND1, ERBB2, XIAP
21MP:00107716.5CTNNB1, TP63, TP53, CCND1, S100B, ERBB2
22MP:00053866.4TP63, TP53, CCND1, S100B, ERBB2, XIAP

Publications for Pleomorphic Adenoma

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Articles related to Pleomorphic Adenoma:

(show top 50)    (show all 668)
idTitleAuthorsYear
1
Management of pleomorphic adenoma in the nasopharynx: a case report. (25759784)
2015
2
Cellular senescence and autophagy of myoepithelial cells are involved in the progression of in situ areas of carcinoma ex-pleomorphic adenoma to invasive carcinoma. An in vitro model. (25895748)
2015
3
Salivary duct carcinoma ex pleomorphic adenoma of the palate: a case report. (25579019)
2015
4
MRI criteria for the diagnosis of pleomorphic adenoma: a validation study. (25128908)
2014
5
Nasopharyngeal pleomorphic adenoma presenting as otitis media with effusion: case report and literature review. (24051236)
2014
6
Surgical management of pleomorphic adenoma of parotid gland in elderly patients: Role of morphological features. (25159550)
2014
7
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. (24121173)
2013
8
Lacrimal gland pleomorphic adenoma: an inconceivable diagnosis in a child. (23667244)
2013
9
Salivary gland pleomorphic adenoma with giant cell tumor component. (23349467)
2013
10
Lacrimal gland pleomorphic adenoma masquerading as thyroid-associated ophthalmopathy. (23514669)
2013
11
Imaging findings of parapharyngeal space pleomorphic adenoma in comparison with parotid gland pleomorphic adenoma. (23990367)
2013
12
A rare case of nasopharyngeal pleomorphic adenoma. (23738174)
2013
13
Ectopic pleomorphic adenoma. (22536563)
2012
14
Lacrimal gland pleomorphic adenoma. (22656910)
2012
15
Chromosomal aberrations in minor salivary gland pleomorphic adenoma. (22695012)
2012
16
Pleomorphic adenoma in ectopic salivary gland tissue in the neck. (23397772)
2012
17
Carcinoma ex pleomorphic adenoma of the parotid gland. (22287150)
2012
18
Invasive salivary duct carcinoma ex pleomorphic adenoma of the parotid gland: a teaching case giving rise to the genuine diagnostic difficulty on an inadequate cytology specimen. (22647549)
2012
19
Pleomorphic adenoma of the lower lip: A rare site of location. (22540103)
2011
20
Increased mucin 1 expression in recurrence and malignant transformation of salivary gland pleomorphic adenoma. (21323961)
2011
21
Stepwise regional and distant progression of recurrent pleomorphic adenoma. (21303593)
2011
22
Immunohistochemical expression of progesterone receptors in pleomorphic adenoma and adenoid cystic carcinoma. (21546738)
2011
23
Pleomorphic adenoma of nasal septum: a case report. (20420081)
2010
24
Multicentric recurrent parotid pleomorphic adenoma in a child. (20173712)
2010
25
Pleomorphic adenoma of the main bronchus in an adult treated using a wedge bronchiectomy. (19160012)
2009
26
Primary pleomorphic adenoma of minor salivary gland in the parapharyngeal space. (19909506)
2009
27
Tumoral mass presenting in the nasomalar region arising from the lateral nasal wall: pleomorphic adenoma. (17549505)
2007
28
Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. (17881995)
2007
29
Interesting Case: Maxillary swing approach for resection of a large pleomorphic adenoma arising in the soft palate. (16055235)
2006
30
Pleomorphic adenoma of the nasal septum and its relationship with Epstein-Barr virus. (16895748)
2006
31
Lipomatous pleomorphic adenoma of the ceruminous gland. (16398681)
2006
32
Carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma. (16086968)
2005
33
Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature. (15991841)
2005
34
Pleomorphic adenoma of the breast: case report and review of the literature. (16299746)
2005
35
Loss of heterozygosity occurs predominantly, but not exclusively, in the epithelial compartment of pleomorphic adenoma. (16026648)
2005
36
Salivary gland-type mixed tumor (pleomorphic adenoma) of the lung. (17670335)
2004
37
Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. (12406304)
2002
38
Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas. (11894114)
2002
39
Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. (11431714)
2001
40
Histologic localization of PLAG1 (pleomorphic adenoma gene 1) in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells. (11555676)
2001
41
Pleomorphic adenoma gene 1 is expressed in cultured benign and malignant salivary gland tumor cells. (10334569)
1999
42
Immunohistochemical localization of fibroblast growth factors (FGFs) and FGF receptor-1 in human normal salivary glands and pleomorphic adenomas. (9725564)
1998
43
Immunohistochemical demonstration of bone morphogenetic protein-2 and type II collagen in pleomorphic adenoma of salivary glands. (9725565)
1998
44
Myoepithelial carcinoma with predominance of plasmacytoid cells arising in a pleomorphic adenoma of the parotid gland. (9839176)
1998
45
DNA flow cytometry and glial fibrillary acidic protein reactivity in pleomorphic adenomas of the salivary glands. (8908307)
1996
46
Expression of keratin mRNAs and proteins in normal salivary epithelia and pleomorphic adenomas. (7506306)
1993
47
Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). (7907371)
1993
48
Pleomorphic adenoma (benign mixed tumor) of the trachea. (1329058)
1992
49
Immunohistochemical study of monomorphic adenoma (clear cell and basal cell) and pleomorphic adenoma of the parotid gland]. (1897371)
1991
50
Abundant dendritic cells express HLA-DR in pleomorphic adenomas. (1980169)
1990

Variations for Pleomorphic Adenoma

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Expression for genes affiliated with Pleomorphic Adenoma

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Search GEO for disease gene expression data for Pleomorphic Adenoma.

Pathways for genes affiliated with Pleomorphic Adenoma

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Pathways related to Pleomorphic Adenoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CCND1, CCNA2
29.3TP53, CDKN2A
3
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
9.3CDKN2A, CCND1, CCNA2
4
Show member pathways
9.1TP53, CCND1
5
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.1CTNNB1, ERBB2, CCND1
6
Show member pathways
9.0CDKN2A, CCNA2, TP53
7
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.0TP53, ERBB2, XIAP
88.9TP53, CCNA2, CD44
98.9TP53, CDKN2A, CD44
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.9CTNNB1, XIAP, TP53
118.9TP53, CDKN2A, CTNNB1
128.8TP53, CCND1, XIAP
13
Show member pathways
8.8TP53, ERBB2, CTNNB1
148.8CCND1, CCNA2, TP53
158.8CCND1, CCNA2, TP53
16
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.8CCND1, CCNA2, TP53
178.8CCND1, CCNA2, TP53
18
Show member pathways
DNA damage response36
8.8TP53, CCND1, CDKN2A
19
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
8.8ERBB2, CCND1, TP53
20
Show member pathways
8.7CDKN2A, TP53, TP63
218.7TP53, CCND1, CTNNB1
228.7TP53, CCND1, CTNNB1
238.7CTNNB1, CCND1, TP53
24
Show member pathways
Wnt Signaling Pathway NetPath36
8.7CTNNB1, CCND1, TP53
258.7CTNNB1, CCND1, TP53
268.7CTNNB1, CCND1, TP53
27
Show member pathways
8.5CD44, CDKN2A, ERBB2, TP53
288.5CTNNB1, XIAP, ERBB2, TP53
29
Show member pathways
8.5TP53, CCNA2, CCND1, CDKN2A
30
Show member pathways
8.5TP53, CCNA2, CCND1, CDKN2A
31
Show member pathways
Cell cycle36
8.5TP53, CCNA2, CCND1, CDKN2A
328.5TP53, CCNA2, CCND1, CDKN2A
33
Show member pathways
8.5TP53, CCNA2, CCND1, CDKN2A
34
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
8.4CCND1, ERBB2, XIAP, CD44, CTNNB1
35
Show member pathways
8.4TP53, CCND1, ERBB2, CDKN2A
36
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
8.4TP63, TP53, XIAP, CDKN2A
378.3CTNNB1, CDKN2A, CCND1, TP53
38
Show member pathways
Signal transduction PTEN pathway58
8.3TP53, CCND1, ERBB2, CTNNB1
398.3TP53, CCND1, CD44, CTNNB1
40
Show member pathways
8.1TP53, CCNA2, CCND1, ERBB2, CDKN2A
41
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.1TP53, CCNA2, CCND1, XIAP, CTNNB1
428.0TP53, CCND1, XIAP, CDKN2A, CTNNB1
438.0TP53, CCNA2, CCND1, ERBB2, CTNNB1
44
Show member pathways
Signaling Pathways in Glioblastoma36
8.0TP53, CCND1, ERBB2, CDKN2A, CTNNB1
45
Show member pathways
8.0TP53, CCND1, ERBB2, CDKN2A, CTNNB1
467.9CTNNB1, CD44, ERBB2, CCND1, TP53
47
Show member pathways
7.8TP63, TP53, CCNA2, CCND1, CDKN2A
487.7TP53, CCND1, ERBB2, XIAP, CDKN2A, CTNNB1
49
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
7.5CTNNB1, CD44, CDKN2A, ERBB2, CCND1, TP53
507.4TP63, TP53, CCND1, ERBB2, CDKN2A, CD44

Compounds for genes affiliated with Pleomorphic Adenoma

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Compounds related to Pleomorphic Adenoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1lovastatin43 49 59 28 1212.9CCND1, CTNNB1, CDKN2A, XIAP, CCNA2
2olomoucine43 129.8CCNA2, TP53, CDKN2A, CCND1
3oxaliplatin43 49 1210.8XIAP, ERBB2, TP53, CCNA2
4depsipeptide438.7TP53, CCNA2, CCND1, CDKN2A
5suberoylanilide hydroxamic acid438.7ERBB2, TP53, CCND1, XIAP
6indole-3-carbinol438.7XIAP, CTNNB1, CCND1, TP53
7sulindac43 129.6TP53, CTNNB1, XIAP, CCND1
8crcs438.6TP53, CCND1, CDKN2A, CTNNB1
9docetaxel43 49 59 1211.6TP53, CDKN2A, ERBB2, XIAP, CCNA2
104-hydroxytamoxifen438.6CTNNB1, S100B, CCND1, ERBB2
11agar438.6CCND1, XIAP, CDKN2A, CTNNB1, ERBB2
12imatinib43 49 1210.6XIAP, ERBB2, CTNNB1, CCND1, S100B
13celecoxib43 59 28 49 24 1213.5CTNNB1, CCNA2, CCND1, ERBB2
14gemcitabine43 49 1210.5CCNA2, CCND1, XIAP, ERBB2, TP53
15bortezomib43 49 1210.5TP53, ERBB2, XIAP, CCND1
16thymidylate438.4CDKN2A, TP53, CCNA2, ERBB2, CCND1
17adpribose438.4CCNA2, TP53, CTNNB1, XIAP, CCND1
18curcumin438.2CCND1, TP53, XIAP, CTNNB1, ERBB2
195fluorouracil438.2TP53, CCNA2, ERBB2, XIAP, CDKN2A, CTNNB1
20flavopiridol43 129.2XIAP, TP53, CDKN2A, CCNA2, ERBB2, CCND1
21vincristine43 49 1210.2CD44, XIAP, CCND1, CCNA2, TP53, CDKN2A
22roscovitine438.1CDKN2A, CTNNB1, CCND1, XIAP, TP53, CCNA2
23mg 13243 599.1CDKN2A, TP53, CTNNB1, CCNA2, CCND1, XIAP
24resveratrol43 59 24 1211.1TP53, CCNA2, CTNNB1, XIAP, ERBB2, CCND1
25arsenite43 249.1CDKN2A, XIAP, TP53, CCNA2, CCND1, CTNNB1
26etoposide43 49 59 1211.1XIAP, CD44, ERBB2, TP53, CCNA2, S100B
27egcg438.1TP53, ERBB2, XIAP, CDKN2A, CCND1, CTNNB1
28dexamethasone43 49 28 1211.1XIAP, S100B, ERBB2, CCNA2, CDKN2A, CD44
29bromodeoxyuridine438.0CTNNB1, TP63, CCNA2, S100B, CCND1, CD44
30h2o2437.9XIAP, CTNNB1, ERBB2, CCNA2, TP53, CDKN2A
31tamoxifen43 49 28 1210.9TP53, CCNA2, CCND1, ERBB2, CD44, CTNNB1
32n acetylcysteine437.9CDKN2A, TP53, ERBB2, CCND1, CTNNB1
33butyrate437.7CCNA2, CTNNB1, CDKN2A, XIAP, CD44, TP53
34adriamycin437.7TP53, XIAP, ERBB2, CTNNB1, CD44, CCND1
35ly294002437.7XIAP, TP53, CCNA2, CD44, ERBB2, CCND1
36cycloheximide437.3CDKN2A, CD44, CTNNB1, CCND1, XIAP, ERBB2
37testosterone43 59 24 1210.3CCND1, CCNA2, S100B, TP63, ERBB2, CDKN2A
38steroid437.3TP63, S100B, CDKN2A, CCND1, CD44, CCNA2
39thymidine43 248.2CCND1, CD44, S100B, TP63, CTNNB1, TP53
40tyrosine437.1TP63, CCNA2, CCND1, S100B, CD44, ERBB2
41arginine437.0CTNNB1, CCNA2, TP53, TP63, S100B, ERBB2
42paclitaxel43 49 128.8TP53, CCNA2, CCND1, S100B, ERBB2, XIAP
43serine436.8S100B, ERBB2, XIAP, CDKN2A, CD44, CTNNB1
44doxorubicin43 49 128.8CTNNB1, CD44, CDKN2A, XIAP, CCND1, CCNA2
45cisplatin43 49 59 129.7TP63, TP53, CCNA2, CD44, CTNNB1, ERBB2
46retinoic acid43 247.6TP63, CTNNB1, S100B, CD44, CDKN2A, XIAP
47progesterone43 28 59 24 1210.5TP63, TP53, CCNA2, CCND1, S100B, CDKN2A
48estrogen436.5CTNNB1, TP63, TP53, CCNA2, CCND1, S100B
49paraffin436.2S100B, CCND1, CTNNB1, CCNA2, TP53, TP63
50vegf436.2TP53, CCNA2, CCND1, S100B, ERBB2, XIAP

GO Terms for genes affiliated with Pleomorphic Adenoma

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Cellular components related to Pleomorphic Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.3CDKN2A, TP53
2basolateral plasma membraneGO:00163239.1ERBB2, CD44, CTNNB1
3nucleoplasmGO:00056547.5TP63, TP53, CCNA2, CCND1, CDKN2A, CTNNB1
4cytosolGO:00058297.1TP63, TP53, CCND1, XIAP, CDKN2A, CTNNB1
5cytoplasmGO:00057376.4CTNNB1, TP63, TP53, CCNA2, S100B, ERBB2
6nucleusGO:00056346.2TP63, TP53, CCNA2, CCND1, S100B, ERBB2

Biological processes related to Pleomorphic Adenoma according to GeneCards Suite gene sharing:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of G2/M transition of mitotic cell cycleGO:001038910.2CDKN2A, CCNA2
2negative regulation of immature T cell proliferation in thymusGO:003308810.1CDKN2A, ERBB2
3regulation of angiogenesisGO:00457659.9ERBB2, CTNNB1
4replicative senescenceGO:00903999.7CDKN2A, TP53
5proximal/distal pattern formationGO:00099549.7TP63, CTNNB1
6Wnt signaling pathwayGO:00160559.6XIAP, CD44, CTNNB1
7hair follicle morphogenesisGO:00310699.6TP63, CTNNB1
8positive regulation of cell cycle arrestGO:00711589.6CDKN2A, TP53
9embryonic limb morphogenesisGO:00303269.4CTNNB1, TP63
10DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.4TP53, TP63
11Ras protein signal transductionGO:00072659.4TP53, CCNA2, CDKN2A
12positive regulation of mesenchymal cell proliferationGO:00020539.3TP63, CTNNB1
13cell agingGO:00075699.3TP53, TP63
14T cell differentiation in thymusGO:00330779.3CTNNB1, TP53
15response to gamma radiationGO:00103329.2TP63, TP53
16intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.2TP53, TP63
17cellular response to UVGO:00346449.1TP63, TP53
18cellular response to DNA damage stimulusGO:00069749.1XIAP, CCND1, TP53
19neuron apoptotic processGO:00514029.0TP63, TP53
20mitotic G1 DNA damage checkpointGO:00315718.9CCND1, TP53, TP63
21response to X-rayGO:00101658.9CCND1, TP53, TP63
22Notch signaling pathwayGO:00072198.9CCND1, TP53, TP63
23negative regulation of apoptotic processGO:00430668.7TP63, TP53, XIAP, CD44
24negative regulation of transcription, DNA-templatedGO:00458928.6TP63, TP53, CDKN2A, CTNNB1
25apoptotic processGO:00069158.6TP63, TP53, XIAP, CTNNB1
26positive regulation of transcription from RNA polymerase II promoterGO:00459448.4TP63, TP53, CDKN2A, CTNNB1
27positive regulation of apoptotic processGO:00430658.4CTNNB1, S100B, TP53
28negative regulation of transcription from RNA polymerase II promoterGO:00001228.4TP63, TP53, CCND1, CTNNB1
29positive regulation of transcription, DNA-templatedGO:00458938.3TP63, TP53, CCNA2, CDKN2A, CTNNB1

Molecular functions related to Pleomorphic Adenoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:00973719.4CDKN2A, TP53
2damaged DNA bindingGO:00036849.0TP53, TP63
3protein phosphatase bindingGO:00199038.9CTNNB1, ERBB2, TP53
4p53 bindingGO:00020398.9CDKN2A, TP53, TP63
5transcription factor bindingGO:00081348.5TP53, CCND1, CDKN2A, CTNNB1
6transcription regulatory region DNA bindingGO:00442128.5CTNNB1, TP53, TP63
7enzyme bindingGO:00198998.4TP53, CCND1, CTNNB1
8protein kinase bindingGO:00199018.2TP53, CCNA2, CCND1, CDKN2A, CTNNB1
9identical protein bindingGO:00428028.1TP63, TP53, S100B, ERBB2
10protein bindingGO:00055155.7CTNNB1, DENR, TP63, TP53, CCNA2, CCND1

Products for genes affiliated with Pleomorphic Adenoma

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Sources for Pleomorphic Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet