MCID: PLM014
MIFTS: 62

Pleomorphic Adenoma malady

Cancer diseases, Endocrine diseases, Oral diseases categories
Download this MalaCard

Summaries for Pleomorphic Adenoma

About this section
Sources:
8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation... more...

MalaCards: Pleomorphic Adenoma, also known as mixed tumor of the salivary gland, is related to adenoma and myoepithelioma. An important gene associated with Pleomorphic Adenoma is DENR (density-regulated protein), and among its related pathways are IL-2 Gene Expression in Activated and Quiescent T-Cells and Inhibition of Ribosome Biogenesis by p14(ARF). The compounds lovastatin and olomoucine have been mentioned in the context of this disorder. Affiliated tissues include the salivary gl, salivary gland and breast, and related mouse phenotypes are limbs/digits/tail and nervous system.

Disease Ontology:8 A gastrointestinal benign neoplasm that is a located in the salivary glands.

Description from OMIM:47 181030

Aliases & Classifications for Pleomorphic Adenoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 47OMIM, 35MeSH, 58SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases, Oral diseases


Aliases & Descriptions:

pleomorphic adenoma 8 10
mixed tumor of the salivary gland 8
mixed salivary gland tumor 62
adenoma pleomorphic 45


External Ids:

Disease Ontology8 DOID:452
SNOMED-CT58 8360001
OMIM47 181030
MeSH35 D008949

Related Diseases for Pleomorphic Adenoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pleomorphic Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.9CD44, CDKN2A, CCND1, TP63, TP53, CTNNB1
2myoepithelioma31.0TP63, S100B
3adenoid cystic carcinoma30.9S100B, CCND1, TP63, ERBB2
4adenocarcinoma30.6CTNNB1, TP53, CCND1, ERBB2, XIAP, TP63
5breast cancer30.1ERBB2, CCND1, CTNNB1
6neuroendocrine carcinoma30.1S100B, TP63
7basal cell carcinoma30.0CTNNB1, TP53, TP63, CD44
8sarcoma30.0TP63, CCNA2, S100B, TP53
9retinoblastoma30.0CDKN2A, ERBB2, CCND1, TP53, CCNA2
10astrocytoma30.0CD44, CDKN2A, TP53, S100B, CCNA2
11melanoma29.9CDKN2A, TP63, TP53, CCNA2, CCND1, S100B
12lung cancer29.9TP53, CCNA2, ERBB2, XIAP, CD44, TP63
13adenoiditis10.7
14mucoepidermoid carcinoma10.6
15pleomorphic adenoma carcinoma10.5
16nasopharyngitis10.5
17syringoma10.4
18epithelial-myoepithelial carcinoma10.4
19polymorphous low-grade adenocarcinoma10.4
20mixed lacrimal gland cancer10.2
21chordoma10.2
22fasciitis10.2
23lipoma10.2
24otitis media10.2
25thyroiditis10.2
26turcot syndrome10.1CTNNB1
27gemistocytic astrocytoma10.1S100B
28meningioma10.1S100B
29large cell neuroendocrine carcinoma10.1
30exophthalmos10.1
31orbit lymphoma10.1
32sialadenitis10.1
33nodular hidradenoma10.1
34clear cell sarcoma10.1
35myxoid liposarcoma10.1
36chondroid lipoma10.1
37spindle cell lipoma10.1
38bilateral retinoblastoma10.1
39parotid gland cancer10.1
40small cell carcinoma10.1
41adenocarcinoma in situ10.1
42asthma10.1
43cervicitis10.1
44giant cell tumor10.1
45hepatitis10.1
46hidradenoma10.1
47hodgkin's lymphoma10.1
48in situ carcinoma10.1
49laryngitis10.1
50leiomyomatosis10.1

Graphical network of the top 20 diseases related to Pleomorphic Adenoma:



Diseases related to pleomorphic adenoma

Symptoms for Pleomorphic Adenoma

About this section
Sources:
47OMIM
See all sources


Clinical features from OMIM:

181030

Drugs & Therapeutics for Pleomorphic Adenoma

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Adenoma

Search NIH Clinical Center for Pleomorphic Adenoma

Genetic Tests for Pleomorphic Adenoma

About this section

Anatomical Context for Pleomorphic Adenoma

About this section
Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Pleomorphic Adenoma:

33
Salivary gland, Breast, Trachea, Bone, Tongue, Lung, Kidney, Smooth muscle, Thyroid, Skin, Testes, Lymph node

FMA organs/tissues related to Pleomorphic Adenoma:

14
The salivary gl

Animal Models for Pleomorphic Adenoma or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Pleomorphic Adenoma:

37 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053717.7TP63, TP53, ERBB2, XIAP, CD44, CTNNB1
2MP:00036317.5CTNNB1, CD44, CDKN2A, ERBB2, CCND1, TP53
3MP:00053807.4TP63, TP53, CCNA2, ERBB2, CDKN2A, CTNNB1
4MP:00053917.4TP63, TP53, CCND1, CDKN2A, CD44, CTNNB1
5MP:00053697.4TP63, TP53, ERBB2, XIAP, CDKN2A, CD44
6MP:00053827.4TP63, TP53, CCND1, ERBB2, CTNNB1
7MP:00053977.3TP53, CCNA2, CCND1, XIAP, CDKN2A, CD44
8MP:00020067.3TP63, TP53, CCND1, ERBB2, CDKN2A, CD44
9MP:00053887.2TP63, TP53, CCND1, ERBB2, CDKN2A, CD44
10MP:00053817.2TP63, TP53, CCND1, ERBB2, CDKN2A, CD44
11MP:00053857.1TP63, TP53, CCND1, ERBB2, XIAP, CD44
12MP:00053797.0TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
13MP:00053907.0TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
14MP:00053896.9TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
15MP:00053876.9TP63, TP53, CCNA2, CCND1, XIAP, CDKN2A
16MP:00053786.8TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
17MP:00028736.8TP63, TP53, CCND1, S100B, ERBB2, XIAP
18MP:00053766.7TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
19MP:00053846.6TP63, TP53, CCNA2, CCND1, ERBB2, XIAP
20MP:00107686.5TP63, TP53, CCNA2, CCND1, ERBB2, XIAP
21MP:00107716.5CTNNB1, TP63, TP53, CCND1, S100B, ERBB2
22MP:00053866.4TP63, TP53, CCND1, S100B, ERBB2, XIAP

Publications for Pleomorphic Adenoma

About this section
Sources:
52PubMed
See all sources

Articles related to Pleomorphic Adenoma:

(show top 50)    (show all 627)
idTitleAuthorsYear
1
Nasopharyngeal pleomorphic adenoma presenting as otitis media with effusion: case report and literature review. (24051236)
2014
2
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. (24121173)
2013
3
Lacrimal gland pleomorphic adenoma: an inconceivable diagnosis in a child. (23667244)
2013
4
Salivary gland pleomorphic adenoma with giant cell tumor component. (23349467)
2013
5
Lacrimal gland pleomorphic adenoma masquerading as thyroid-associated ophthalmopathy. (23514669)
2013
6
Imaging findings of parapharyngeal space pleomorphic adenoma in comparison with parotid gland pleomorphic adenoma. (23990367)
2013
7
A rare case of nasopharyngeal pleomorphic adenoma. (23738174)
2013
8
Ectopic pleomorphic adenoma. (22536563)
2012
9
Lacrimal gland pleomorphic adenoma. (22656910)
2012
10
Chromosomal aberrations in minor salivary gland pleomorphic adenoma. (22695012)
2012
11
Pleomorphic adenoma in ectopic salivary gland tissue in the neck. (23397772)
2012
12
Carcinoma ex pleomorphic adenoma of the parotid gland. (22287150)
2012
13
Invasive salivary duct carcinoma ex pleomorphic adenoma of the parotid gland: a teaching case giving rise to the genuine diagnostic difficulty on an inadequate cytology specimen. (22647549)
2012
14
Pleomorphic adenoma of the lower lip: A rare site of location. (22540103)
2011
15
Increased mucin 1 expression in recurrence and malignant transformation of salivary gland pleomorphic adenoma. (21323961)
2011
16
Stepwise regional and distant progression of recurrent pleomorphic adenoma. (21303593)
2011
17
Immunohistochemical expression of progesterone receptors in pleomorphic adenoma and adenoid cystic carcinoma. (21546738)
2011
18
Pleomorphic adenoma of nasal septum: a case report. (20420081)
2010
19
Multicentric recurrent parotid pleomorphic adenoma in a child. (20173712)
2010
20
Immunohistochemical expression of estrogens and progesterone receptors in carcinoma ex pleomorphic adenoma-undifferentiated and adenocarcinoma types. (20038908)
2010
21
Pleomorphic adenoma of the main bronchus in an adult treated using a wedge bronchiectomy. (19160012)
2009
22
Primary pleomorphic adenoma of minor salivary gland in the parapharyngeal space. (19909506)
2009
23
Tumoral mass presenting in the nasomalar region arising from the lateral nasal wall: pleomorphic adenoma. (17549505)
2007
24
Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. (17881995)
2007
25
Imaging characteristics of recurrent pleomorphic adenoma of the parotid gland. (17846206)
2007
26
Interesting Case: Maxillary swing approach for resection of a large pleomorphic adenoma arising in the soft palate. (16055235)
2006
27
Pleomorphic adenoma of the nasal septum and its relationship with Epstein-Barr virus. (16895748)
2006
28
Lipomatous pleomorphic adenoma of the ceruminous gland. (16398681)
2006
29
Carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma. (16086968)
2005
30
Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature. (15991841)
2005
31
Pleomorphic adenoma of the breast: case report and review of the literature. (16299746)
2005
32
Loss of heterozygosity occurs predominantly, but not exclusively, in the epithelial compartment of pleomorphic adenoma. (16026648)
2005
33
Salivary gland-type mixed tumor (pleomorphic adenoma) of the lung. (17670335)
2004
34
Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. (12406304)
2002
35
Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas. (11894114)
2002
36
Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. (11431714)
2001
37
Histologic localization of PLAG1 (pleomorphic adenoma gene 1) in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells. (11555676)
2001
38
Pleomorphic adenoma gene 1 is expressed in cultured benign and malignant salivary gland tumor cells. (10334569)
1999
39
Immunohistochemical localization of fibroblast growth factors (FGFs) and FGF receptor-1 in human normal salivary glands and pleomorphic adenomas. (9725564)
1998
40
Immunohistochemical demonstration of bone morphogenetic protein-2 and type II collagen in pleomorphic adenoma of salivary glands. (9725565)
1998
41
Myoepithelial carcinoma with predominance of plasmacytoid cells arising in a pleomorphic adenoma of the parotid gland. (9839176)
1998
42
Mucoepidermoid carcinoma ex pleomorphic adenoma: nonspecific preoperative cytologic findings in six cases. (9723598)
1998
43
Effects of acidic and basic fibroblast growth factors on cell proliferation in pleomorphic adenoma of the parotid gland. (9288226)
1997
44
DNA flow cytometry and glial fibrillary acidic protein reactivity in pleomorphic adenomas of the salivary glands. (8908307)
1996
45
Expression of keratin mRNAs and proteins in normal salivary epithelia and pleomorphic adenomas. (7506306)
1993
46
Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). (7907371)
1993
47
Pleomorphic adenoma (benign mixed tumor) of the trachea. (1329058)
1992
48
Immunohistochemical study of monomorphic adenoma (clear cell and basal cell) and pleomorphic adenoma of the parotid gland]. (1897371)
1991
49
Abundant dendritic cells express HLA-DR in pleomorphic adenomas. (1980169)
1990
50
Glial fibrillary acidic protein expression in pleomorphic adenoma of salivary gland: an immunoelectron microscopic study. (2192489)
1990

Variations for Pleomorphic Adenoma

About this section

Expression for genes affiliated with Pleomorphic Adenoma

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pleomorphic Adenoma

Search GEO for disease gene expression data for Pleomorphic Adenoma.

Pathways for genes affiliated with Pleomorphic Adenoma

About this section
Sources:
50PathCards, 53QIAGEN, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 61Tocris Bioscience, 51PharmGKB, 54R&D Systems, 57SinoBiological, 5Cell Signaling Technology
See all sources

Pathways related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CCND1, CCNA2
29.3TP53, CDKN2A
3
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.3CDKN2A, CCND1, CCNA2
4
Show member pathways
9.1TP53, CCND1
5
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1CTNNB1, ERBB2, CCND1
6
Show member pathways
9.0CDKN2A, CCNA2, TP53
7
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0TP53, ERBB2, XIAP
88.9TP53, CCNA2, CD44
98.9TP53, CDKN2A, CD44
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
8.9CTNNB1, XIAP, TP53
118.9TP53, CDKN2A, CTNNB1
128.8TP53, CCND1, XIAP
13
Show member pathways
8.8TP53, ERBB2, CTNNB1
148.8CCND1, CCNA2, TP53
158.8CCND1, CCNA2, TP53
16
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.8CCND1, CCNA2, TP53
178.8CCND1, CCNA2, TP53
18
Show member pathways
DNA damage response38
8.8TP53, CCND1, CDKN2A
19
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
8.8ERBB2, CCND1, TP53
20
Show member pathways
8.7CDKN2A, TP53, TP63
218.7TP53, CCND1, CTNNB1
228.7TP53, CCND1, CTNNB1
238.7CTNNB1, CCND1, TP53
24
Show member pathways
Wnt Signaling Pathway NetPath38
8.7CTNNB1, CCND1, TP53
258.7CTNNB1, CCND1, TP53
268.7CTNNB1, CCND1, TP53
27
Show member pathways
8.5CD44, CDKN2A, ERBB2, TP53
288.5CTNNB1, XIAP, ERBB2, TP53
29
Show member pathways
8.5TP53, CCNA2, CCND1, CDKN2A
30
Show member pathways
8.5TP53, CCNA2, CCND1, CDKN2A
31
Show member pathways
Cell cycle38
8.5TP53, CCNA2, CCND1, CDKN2A
328.5TP53, CCNA2, CCND1, CDKN2A
33
Show member pathways
8.5TP53, CCNA2, CCND1, CDKN2A
34
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.4CCND1, ERBB2, XIAP, CD44, CTNNB1
35
Show member pathways
8.4TP53, CCND1, ERBB2, CDKN2A
36
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.4TP63, TP53, XIAP, CDKN2A
378.3CTNNB1, CDKN2A, CCND1, TP53
38
Show member pathways
Signal transduction PTEN pathway60
8.3TP53, CCND1, ERBB2, CTNNB1
398.3TP53, CCND1, CD44, CTNNB1
40
Show member pathways
8.1TP53, CCNA2, CCND1, ERBB2, CDKN2A
41
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.1TP53, CCNA2, CCND1, XIAP, CTNNB1
428.0TP53, CCND1, XIAP, CDKN2A, CTNNB1
438.0TP53, CCNA2, CCND1, ERBB2, CTNNB1
44
Show member pathways
Signaling Pathways in Glioblastoma38
8.0TP53, CCND1, ERBB2, CDKN2A, CTNNB1
45
Show member pathways
8.0TP53, CCND1, ERBB2, CDKN2A, CTNNB1
467.9CTNNB1, CD44, ERBB2, CCND1, TP53
47
Show member pathways
7.8TP63, TP53, CCNA2, CCND1, CDKN2A
487.7TP53, CCND1, ERBB2, XIAP, CDKN2A, CTNNB1
49
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
7.5CTNNB1, CD44, CDKN2A, ERBB2, CCND1, TP53
507.4TP63, TP53, CCND1, ERBB2, CDKN2A, CD44

Compounds for genes affiliated with Pleomorphic Adenoma

About this section
Sources:
45Novoseek, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1lovastatin45 51 61 29 1112.9CCND1, CTNNB1, CDKN2A, XIAP, CCNA2
2olomoucine45 119.8CCNA2, TP53, CDKN2A, CCND1
3oxaliplatin45 51 1110.8XIAP, ERBB2, TP53, CCNA2
4depsipeptide458.7TP53, CCNA2, CCND1, CDKN2A
5suberoylanilide hydroxamic acid458.7ERBB2, TP53, CCND1, XIAP
6indole-3-carbinol458.7XIAP, CTNNB1, CCND1, TP53
7sulindac45 119.6TP53, CTNNB1, XIAP, CCND1
8crcs458.6TP53, CCND1, CDKN2A, CTNNB1
9docetaxel45 51 61 1111.6TP53, CDKN2A, ERBB2, XIAP, CCNA2
104-hydroxytamoxifen458.6CTNNB1, S100B, CCND1, ERBB2
11agar458.6CCND1, XIAP, CDKN2A, CTNNB1, ERBB2
12imatinib45 51 1110.6XIAP, ERBB2, CTNNB1, CCND1, S100B
13celecoxib45 61 29 51 24 1113.5CTNNB1, CCNA2, CCND1, ERBB2
14gemcitabine45 51 1110.5CCNA2, CCND1, XIAP, ERBB2, TP53
15bortezomib45 51 1110.5TP53, ERBB2, XIAP, CCND1
16thymidylate458.4CDKN2A, TP53, CCNA2, ERBB2, CCND1
17adpribose458.4CCNA2, TP53, CTNNB1, XIAP, CCND1
18curcumin458.2CCND1, TP53, XIAP, CTNNB1, ERBB2
195fluorouracil458.2TP53, CCNA2, ERBB2, XIAP, CDKN2A, CTNNB1
20flavopiridol45 119.2XIAP, TP53, CDKN2A, CCNA2, ERBB2, CCND1
21vincristine45 51 1110.2CD44, XIAP, CCND1, CCNA2, TP53, CDKN2A
22roscovitine458.1CDKN2A, CTNNB1, CCND1, XIAP, TP53, CCNA2
23mg 13245 619.1CDKN2A, TP53, CTNNB1, CCNA2, CCND1, XIAP
24resveratrol45 61 24 1111.1TP53, CCNA2, CTNNB1, XIAP, ERBB2, CCND1
25arsenite45 249.1CDKN2A, XIAP, TP53, CCNA2, CCND1, CTNNB1
26etoposide45 51 61 1111.1XIAP, CD44, ERBB2, TP53, CCNA2, S100B
27egcg458.1TP53, ERBB2, XIAP, CDKN2A, CCND1, CTNNB1
28dexamethasone45 51 29 1111.1XIAP, S100B, ERBB2, CCNA2, CDKN2A, CD44
29bromodeoxyuridine458.0CTNNB1, TP63, CCNA2, S100B, CCND1, CD44
30h2o2457.9XIAP, CTNNB1, ERBB2, CCNA2, TP53, CDKN2A
31tamoxifen45 51 29 1110.9TP53, CCNA2, CCND1, ERBB2, CD44, CTNNB1
32n acetylcysteine457.9CDKN2A, TP53, ERBB2, CCND1, CTNNB1
33butyrate457.7CCNA2, CTNNB1, CDKN2A, XIAP, CD44, TP53
34adriamycin457.7TP53, XIAP, ERBB2, CTNNB1, CD44, CCND1
35ly294002457.7XIAP, TP53, CCNA2, CD44, ERBB2, CCND1
36cycloheximide457.3CDKN2A, CD44, CTNNB1, CCND1, XIAP, ERBB2
37testosterone45 61 24 1110.3CCND1, CCNA2, S100B, TP63, ERBB2, CDKN2A
38steroid457.3TP63, S100B, CDKN2A, CCND1, CD44, CCNA2
39thymidine45 248.2CCND1, CD44, S100B, TP63, CTNNB1, TP53
40tyrosine457.1TP63, CCNA2, CCND1, S100B, CD44, ERBB2
41arginine457.0CTNNB1, CCNA2, TP53, TP63, S100B, ERBB2
42paclitaxel45 51 118.8TP53, CCNA2, CCND1, S100B, ERBB2, XIAP
43serine456.8S100B, ERBB2, XIAP, CDKN2A, CD44, CTNNB1
44doxorubicin45 51 118.8CTNNB1, CD44, CDKN2A, XIAP, CCND1, CCNA2
45cisplatin45 51 61 119.7TP63, TP53, CCNA2, CD44, CTNNB1, ERBB2
46retinoic acid45 247.6TP63, CTNNB1, S100B, CD44, CDKN2A, XIAP
47progesterone45 29 61 24 1110.5TP63, TP53, CCNA2, CCND1, S100B, CDKN2A
48estrogen456.5CTNNB1, TP63, TP53, CCNA2, CCND1, S100B
49paraffin456.2S100B, CCND1, CTNNB1, CCNA2, TP53, TP63
50vegf456.2TP53, CCNA2, CCND1, S100B, ERBB2, XIAP

GO Terms for genes affiliated with Pleomorphic Adenoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.3CDKN2A, TP53
2basolateral plasma membraneGO:0163239.1ERBB2, CD44, CTNNB1
3nucleoplasmGO:0056547.5TP63, TP53, CCNA2, CCND1, CDKN2A, CTNNB1
4cytosolGO:0058297.1TP63, TP53, CCND1, XIAP, CDKN2A, CTNNB1
5cytoplasmGO:0057376.4CTNNB1, TP63, TP53, CCNA2, S100B, ERBB2
6nucleusGO:0056346.2TP63, TP53, CCNA2, CCND1, S100B, ERBB2

Biological processes related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of G2/M transition of mitotic cell cycleGO:01038910.2CDKN2A, CCNA2
2negative regulation of immature T cell proliferation in thymusGO:03308810.1CDKN2A, ERBB2
3regulation of angiogenesisGO:0457659.9ERBB2, CTNNB1
4replicative senescenceGO:0903999.7CDKN2A, TP53
5proximal/distal pattern formationGO:0099549.7TP63, CTNNB1
6Wnt signaling pathwayGO:0160559.6XIAP, CD44, CTNNB1
7hair follicle morphogenesisGO:0310699.6TP63, CTNNB1
8positive regulation of cell cycle arrestGO:0711589.6CDKN2A, TP53
9embryonic limb morphogenesisGO:0303269.4CTNNB1, TP63
10DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4TP53, TP63
11Ras protein signal transductionGO:0072659.4TP53, CCNA2, CDKN2A
12positive regulation of mesenchymal cell proliferationGO:0020539.3TP63, CTNNB1
13cell agingGO:0075699.3TP53, TP63
14T cell differentiation in thymusGO:0330779.3CTNNB1, TP53
15response to gamma radiationGO:0103329.2TP63, TP53
16intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.2TP53, TP63
17cellular response to UVGO:0346449.1TP63, TP53
18cellular response to DNA damage stimulusGO:0069749.1XIAP, CCND1, TP53
19neuron apoptotic processGO:0514029.0TP63, TP53
20mitotic G1 DNA damage checkpointGO:0315718.9CCND1, TP53, TP63
21response to X-rayGO:0101658.9CCND1, TP53, TP63
22Notch signaling pathwayGO:0072198.9CCND1, TP53, TP63
23negative regulation of apoptotic processGO:0430668.7TP63, TP53, XIAP, CD44
24negative regulation of transcription, DNA-templatedGO:0458928.6TP63, TP53, CDKN2A, CTNNB1
25apoptotic processGO:0069158.6TP63, TP53, XIAP, CTNNB1
26positive regulation of transcription from RNA polymerase II promoterGO:0459448.4TP63, TP53, CDKN2A, CTNNB1
27positive regulation of apoptotic processGO:0430658.4CTNNB1, S100B, TP53
28negative regulation of transcription from RNA polymerase II promoterGO:0001228.4TP63, TP53, CCND1, CTNNB1
29positive regulation of transcription, DNA-templatedGO:0458938.3TP63, TP53, CCNA2, CDKN2A, CTNNB1

Molecular functions related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.4CDKN2A, TP53
2damaged DNA bindingGO:0036849.0TP53, TP63
3protein phosphatase bindingGO:0199038.9CTNNB1, ERBB2, TP53
4p53 bindingGO:0020398.9CDKN2A, TP53, TP63
5transcription factor bindingGO:0081348.5TP53, CCND1, CDKN2A, CTNNB1
6transcription regulatory region DNA bindingGO:0442128.5CTNNB1, TP53, TP63
7enzyme bindingGO:0198998.4TP53, CCND1, CTNNB1
8protein kinase bindingGO:0199018.2TP53, CCNA2, CCND1, CDKN2A, CTNNB1
9identical protein bindingGO:0428028.1TP63, TP53, S100B, ERBB2
10protein bindingGO:0055155.7CTNNB1, DENR, TP63, TP53, CCNA2, CCND1

Products for genes affiliated with Pleomorphic Adenoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pleomorphic Adenoma

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet