MCID: PLM014
MIFTS: 62

Pleomorphic Adenoma malady

Endocrine diseases, Cancer diseases categories

Summaries for Pleomorphic Adenoma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation... more...

MalaCards: Pleomorphic Adenoma, also known as mixed tumor of the salivary gland, is related to adenoma and pleomorphic adenoma carcinoma. An important gene associated with Pleomorphic Adenoma is DENR (density-regulated protein), and among its related pathways are Pathways in cancer and HTLV-I infection. The compounds cisplatin and doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include the salivary gl, salivary gland and breast, and related mouse phenotypes are growth/size and reproductive system.

Disease Ontology:8 A gastrointestinal benign neoplasm that is a located in the salivary glands.

Description from OMIM:46 181030

Aliases & Classifications for Pleomorphic Adenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

pleomorphic adenoma 8 10
mixed tumor of the salivary gland 8
mixed salivary gland tumor 60
adenoma pleomorphic 44


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Disease Ontology8 DOID:452
MeSH34 D008949
SNOMED-CT56 8360001
OMIM46 181030

Related Diseases for Pleomorphic Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Pleomorphic Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma32.1TP63, SERPINB5, CCND1, CCNA2, HMGA2, PLAG1
2pleomorphic adenoma carcinoma31.7PDZD11
3adenocarcinoma30.9TP53, TP63, SERPINB5, CCND1, CCNA2, XIAP
4adenoid cystic carcinoma30.9TP63, ERBB2, CCND1, S100B, SERPINB5
5myoepithelioma30.9TP63, GFAP, S100B, SERPINB5
6squamous cell carcinoma30.5HMGA2, TP53, TP63, XIAP, CCND1, CCNA2
7melanoma30.2TP53, TP63, SERPINB5, CDKN2A, XIAP, S100B
8chordoma30.2S100B, GFAP
9lipoma30.2PLAG1, HMGA2
10basal cell carcinoma30.2TP63, CTNNB1, TP53
11retinoblastoma30.0CDKN2A, CCND1, GFAP, ERBB2, TP53, CCNA2
12laryngeal squamous cell carcinoma30.0CDKN2A, CCNA2, TP53, TP63, CCND1
13astrocytoma30.0CCNA2, S100B, MAGEA3, CDKN2A, GFAP, TP53
14sarcoma30.0S100B, SERPINB5, HMGA2, CCNA2, TP53, MAGEA3
15adenomas, salivary gland pleomorphic30.0S100B, HMGA2, PLAG1
16liposarcoma30.0TP53, PLAG1, HMGA2
17lung cancer30.0TP63, TP53, CCNA2, ERBB2, XIAP
18breast cancer30.0SERPINB5, CCND1, CTNNB1, ERBB2
19parathyroid adenoma30.0CCND1
20pleomorphic carcinoma11.1
21adenoiditis10.6
22mucoepidermoid carcinoma10.5
23breast adenoma10.5
24lung adenoma10.5
25nasopharyngitis10.4
26in situ carcinoma10.4
27clear cell adenoma10.4
28syringoma10.3
29epithelial-myoepithelial carcinoma10.3
30mixed lacrimal gland cancer10.2
31adenocarcinoma in situ10.2
32pleomorphic lipoma10.2
33bronchus adenoma10.2
34fasciitis10.2
35lacrimal gland adenocarcinoma10.2
36otitis media10.2
37renal adenoma10.2
38thyroiditis10.2
39sebaceous adenoma10.0
40neuroendocrine carcinoma10.0
41bilateral retinoblastoma10.0
42cystic basal cell carcinoma10.0
43parotid gland cancer10.0
44pleomorphic liposarcoma10.0
45small cell carcinoma10.0
46exophthalmos10.0
47fibrillary astrocytoma10.0
48orbit lymphoma10.0
49pregnancy adenoma10.0
50sialadenitis10.0

Graphical network of the top 20 diseases related to Pleomorphic Adenoma:



Diseases related to pleomorphic adenoma

Clinical Features for Pleomorphic Adenoma

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46OMIM
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Clinical features from OMIM:

181030

Drugs & Therapeutics for Pleomorphic Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pleomorphic Adenoma

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Adenoma

Search NIH Clinical Center for Pleomorphic Adenoma

Search CenterWatch for Pleomorphic Adenoma

Genetic Tests for Pleomorphic Adenoma

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Anatomical Context for Pleomorphic Adenoma

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Pleomorphic Adenoma:

32
Salivary gland, Breast, Trachea, Bone, Tongue, Lung, Smooth muscle, Thyroid, Kidney, Skin, Lymph node, Testis, Testes

FMA organs/tissues related to Pleomorphic Adenoma:

14
The salivary gl

Animal Models for Pleomorphic Adenoma or affiliated genes

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36MGI
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Publications for Pleomorphic Adenoma

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50PubMed
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Articles related to Pleomorphic Adenoma:

(show top 50)    (show all 637)
idTitleAuthorsYear
1
Salivary gland pleomorphic adenoma with giant cell tumor component. (23349467)
2013
2
Carcinoma ex pleomorphic adenoma. Case report. (24027900)
2013
3
Pleomorphic adenoma with unusual cytological findings in aspiration: a diagnostic pitfall in aspiration cytology. (24045395)
2013
4
An unusual case of carcinoma ex pleomorphic adenoma of the parotid metastasizing to the mandible: case report and review of the literature. (22771096)
2013
5
CD24 and CD44 in salivary gland pleomorphic adenoma and in human salivary gland morphogenesis: differential markers of glandular structure or stem cell indicators? (23600676)
2013
6
Pleomorphic adenoma in ectopic salivary gland tissue in the neck. (23397772)
2012
7
A giant pleomorphic adenoma of the submandibular salivary gland: a case report. (23997863)
2012
8
An unusual localization of a pleomorphic adenoma in the rhinopharynx. (22927861)
2012
9
Myoepithelial carcinoma ex pleomorphic adenoma: a rare intraosseous entity. (22727091)
2012
10
Primary central carcinoma ex pleomorphic adenoma of the mandible: report of a rare case and literature review. (21664840)
2011
11
Pleomorphic adenoma of the soft palate: myoepithelial cell predominant. (22484885)
2011
12
WT1 expression in salivary gland pleomorphic adenomas: a reliable marker of the neoplastic myoepithelium. (21057459)
2011
13
Bilateral SMAS rhytidectomy in parotid recurrent pleomorphic adenoma. (22058601)
2011
14
Solitary fibrous tumor with entrapment of minor salivary gland tissue: an unusual presentation that requires exclusion of pleomorphic adenoma. (21424262)
2011
15
Degenerative pleomorphic adenoma of the nasal cavity. (21185250)
2011
16
Expression of CD44V6 in parotid pleomorphic adenoma and carcinoma ex pleomorphic adenoma. (20374021)
2010
17
Oncocytic carcinoma ex pleomorphic adenoma. (20237989)
2010
18
Survey of opinions on the management of pleomorphic adenoma among United Kingdom oral and maxillofacial surgeons. (20465538)
2010
19
Ultrastructural immunolocalization of a cartilage-specific proteoglycan, aggrecan, in salivary pleomorphic adenomas. (19294492)
2009
20
Pleomorphic adenoma in the auricle. (19461339)
2009
21
Collagen type I may influence the expression of E-cadherin and beta-catenin in carcinoma ex-pleomorphic adenoma. (19276972)
2009
22
Gray-scale and color Doppler ultrasonographic features of pleomorphic adenoma and Warthin's tumor in major salivary glands. (19712813)
2009
23
Pleomorphic adenoma of the lateral nasal wall: case report. (18646579)
2008
24
Extensive bone with marrow formation in pleomorphic adenoma. Report of a case. (18366420)
2008
25
Primary unilateral multifocal pleomorphic adenoma of the parotid gland: molecular assessment and literature review. (20614306)
2008
26
Imaging characteristics of recurrent pleomorphic adenoma of the parotid gland. (17846206)
2007
27
Immunolocalization of beta-catenin in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands. (17721271)
2007
28
Ossifying pleomorphic adenoma of the parotid gland: a case report and review. (17991056)
2007
29
Intraosseous pleomorphic adenoma of the mandible: report of a case and review of the literature. (17142071)
2007
30
Immunohistochemical characteristics of bone forming cells in pleomorphic adenoma. (18026564)
2007
31
Pleomorphic adenoma of the palpebral lobe of the lacrimal gland. (17275570)
2007
32
Pleomorphic adenoma of the nasal septum and its relationship with Epstein-Barr virus. (16895748)
2006
33
Pleomorphic adenoma arising in an accessory lacrimal gland of Wolfring. (16530838)
2006
34
Pleomorphic adenoma presenting low T2 signal-intensity on magnetic resonance imaging. (16940488)
2006
35
Pleomorphic adenoma of the vulva: a review illustrated by a clinical case. (16681787)
2006
36
Mucoepidermoid carcinoma arising from pleomorphic adenoma of the soft palate. (17119430)
2006
37
Recurrent pleomorphic adenoma of the parotid gland. (16860648)
2006
38
Metachronous bilateral pleomorphic adenoma of the parotid gland. (16504867)
2006
39
Carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma. (16086968)
2005
40
Pleomorphic adenoma and severe obstructive sleep apnoea. (15845199)
2005
41
Fine-needle aspiration biopsy of cystic pleomorphic adenoma with adnexa-like differentiation mimicking mucoepidermoid carcinoma: a case report. (15754364)
2005
42
Recurrent pleomorphic adenoma of the parotid gland. (16143173)
2005
43
Synchronous mucoepidermoid carcinoma of tongue and pleomorphic adenoma of submandibular gland. (12627105)
2003
44
Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas. (11894114)
2002
45
Effects of acidic and basic fibroblast growth factors on cell proliferation in pleomorphic adenoma of the parotid gland. (9288226)
1997
46
Quantitation and localization of cycling tumor cells in pleomorphic adenomas and myoepitheliomas: an immunohistochemical analysis. (9083936)
1997
47
Immunohistochemical study of c-erbB-2 expression in carcinoma ex-pleomorphic adenoma. (8729044)
1996
48
Pleomorphic adenoma of the lacrimal gland manifesting as exophthalmos in adolescence--case report. (7532802)
1994
49
Comparison of proliferating cell nuclear antigen index in benign and malignant salivary pleomorphic adenoma. (9135975)
1994
50
Overexpression and amplification of c-myc and c-Ha-ras oncogenes in pleomorphic salivary adenoma. (8389270)
1993

Genetic Variations for Pleomorphic Adenoma

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Expression for genes affiliated with Pleomorphic Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleomorphic Adenoma

Search GEO for disease gene expression data for Pleomorphic Adenoma.

Pathways for genes affiliated with Pleomorphic Adenoma

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Sources:
29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 55SinoBiological, 12EMD Millipore, 51QIAGEN, 53Reactome, 59Tocris Bioscience
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Pathways related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5CCND1, XIAP, CTNNB1, CDKN2A, ERBB2, TP53
210.5CCND1, XIAP, CTNNB1, CDKN2A, TP53
310.5TP53, ERBB2, CTNNB1, CCNA2, CCND1
4
Hide members
10.5CCND1, CTNNB1, CDKN2A, ERBB2, TP53
510.5TP53, TP63, SERPINB5, ERBB2, HMGA2, CDKN2A
6
Hide members
10.5CCND1, XIAP, CTNNB1, ERBB2
7
Hide members
10.5CCND1, CCNA2, CDKN2A, TP63
810.5TP53, ERBB2, CTNNB1, XIAP
9
Hide members
10.5XIAP, CTNNB1, ERBB2, TP53
1010.5CCND1, CCNA2, CDKN2A, TP53
11
Hide members
10.5CCND1, CCNA2, CDKN2A, TP53
12
Hide members
10.5CCND1, CDKN2A, ERBB2, TP53
1310.5TP53, CDKN2A, CTNNB1, CCND1
14
Hide members
10.5CCND1, CTNNB1, ERBB2, TP53
1510.5TP53, ERBB2, CTNNB1, CCND1
16
Hide members
10.5CCNA2, CDKN2A, TP53
17
Transcription Androgen Receptor nuclear signaling
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10.5ERBB2, CTNNB1, CCND1
18
Transcription P53 signaling pathway
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10.5CTNNB1, CDKN2A, TP53
1910.5TP53, XIAP, CCND1
20
Hide members
10.5TP53, ERBB2, GDF5, CCNA2
2110.5TP53, TP63, CDKN2A
2210.5TP53, CCNA2, CCND1
2310.5CCND1, CCNA2, TP53
24
Hide members
10.5CCND1, CDKN2A, SERPINB5, TP53
2510.5TP53, CTNNB1, CCND1
26
Hide members
10.5CCND1, GDF5, GFAP, ERBB2, TP53
2710.5CCND1, CCNA2, SERPINB5
28
Hide members
10.5TP53, ERBB2
29
Hide members
10.5TP53, TP63
30
Hide members
10.5TP53

Compounds for genes affiliated with Pleomorphic Adenoma

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1cisplatin44 49 59 1114.0ERBB2, SERPINB5, GFAP, HMGA2, CDKN2A, CCNA2
2doxorubicin44 49 1113.0CCNA2, HMGA2, XIAP, CDKN2A, ERBB2, TP63
3vegf4411.0TP53, S100B, CCND1, CCNA2, XIAP, CTNNB1
4paclitaxel44 49 1113.0CCND1, CCNA2, CDKN2A, S100B, XIAP, TP53
5paraffin4411.0MAGEA3, CCNA2, XIAP, S100B, CTNNB1, HMGA2
6progesterone44 59 28 11 2415.0CTNNB1, CCND1, TP53, TP63, SERPINB5, GFAP
7roscovitine4411.0CCND1, CCNA2, XIAP, CDKN2A, TP53, CTNNB1
8retinoic acid44 2411.9CCND1, TP53, TP63, CTNNB1, CCNA2, XIAP
9flavopiridol44 1111.9CCND1, TP53, ERBB2, CDKN2A, XIAP, CCNA2
10testosterone44 59 11 2413.9GFAP, ERBB2, CCND1, CCNA2, S100B, SERPINB5
11depsipeptide4410.9SERPINB5, CDKN2A, CCNA2, CCND1, TP53
12mg 13244 5911.9XIAP, CCND1, CDKN2A, CCNA2, TP53, CTNNB1
13adriamycin4410.9CDKN2A, CCND1, CTNNB1, XIAP
145fluorouracil4410.9CCNA2, XIAP, CTNNB1, CDKN2A, ERBB2, TP53
15bromodeoxyuridine4410.9CTNNB1, TP63, GFAP, S100B, CCNA2, CCND1
16arsenite44 2411.9TP53, CCND1, CCNA2, XIAP, CDKN2A
17estrogen4410.9GFAP
18resveratrol44 59 11 2413.9ERBB2
19agar4410.9XIAP, CTNNB1, CDKN2A, GFAP, ERBB2, CCND1
20olomoucine44 1111.9CCND1, TP53, CDKN2A, CCNA2
21butyrate4410.9GFAP
22adpribose4410.9CCNA2, CCND1, XIAP, CTNNB1, TP53
23steroid4410.9SERPINB5, ERBB2, CDKN2A, CCNA2, CCND1
24gemcitabine44 49 1112.9CCND1, XIAP, CCNA2, ERBB2, TP53
25lovastatin44 49 59 28 1114.9CDKN2A, CTNNB1, XIAP, CCNA2, CCND1
26oligonucleotide4410.9PLAG1, CDKN2A, CTNNB1, XIAP, CCNA2, CCND1
27cytarabine44 49 1112.9CCNA2, XIAP, CDKN2A, GFAP, TP53
28crcs4410.9TP53, CDKN2A, CTNNB1, CCND1
29thymidylate4410.8ERBB2, CDKN2A, TP53, CCNA2, CCND1
30vincristine44 49 1112.8XIAP, CCND1, CCNA2
31arginine4410.8ERBB2, GFAP, TP63, CDKN2A, CTNNB1, S100B
32thymidine44 2411.8GFAP, CTNNB1, CCNA2, CCND1, S100B, TP63
33aspartate4410.8CTNNB1, CDKN2A, ERBB2, GFAP, S100B, CA3
34tamoxifen44 49 28 1113.8TP53, ERBB2, CCND1, CTNNB1, CCNA2, SERPINB5
35docetaxel44 49 59 1113.8ERBB2, CDKN2A, TP53, XIAP, CCNA2
36indole-3-carbinol4410.8CCND1, TP53, XIAP, CTNNB1
37dutp4410.8XIAP, GFAP, TP53, CCND1
38sulindac44 1111.8CTNNB1, CCND1, XIAP, TP53
39serine4410.8CCND1, CCNA2, GFAP, S100B, ERBB2
40suberoylanilide hydroxamic acid4410.7ERBB2, TP53, XIAP, CCND1
41ly2940024410.7XIAP, CTNNB1, ERBB2, CCND1, TP53, CCNA2
42imatinib44 49 1112.7CCND1, ERBB2, CTNNB1, S100B, XIAP
43oxaliplatin44 49 1112.7TP53, CCNA2, XIAP, ERBB2
44curcumin4410.7TP53, ERBB2, CTNNB1, XIAP, CCND1
45hematoxylin4410.6TP63, GFAP, CDKN2A, S100B
46genistein44 28 59 2 11 2415.6ERBB2, CTNNB1, CCNA2, CCND1, CDKN2A, GFAP
47celecoxib44 59 28 49 11 2415.5CTNNB1, ERBB2, CCND1, CCNA2
48hpvs4410.5CDKN2A, CCNA2, TP53
494-hydroxytamoxifen4410.4CTNNB1, ERBB2, S100B, CCND1
50dexamethasone44 49 28 1113.2GFAP, S100B, XIAP, CCNA2, CTNNB1, CDKN2A

GO Terms for genes affiliated with Pleomorphic Adenoma

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16Gene Ontology
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Cellular components related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1senescence-associated heterochromatin focusGO:03598510.6HMGA2, CDKN2A
2nucleusGO:00563410.5CCND1, CCNA2, XIAP, S100B, CTNNB1, CDKN2A
3nucleoplasmGO:00565410.5CCNA2, CTNNB1, CDKN2A, TP63, TP53, CCND1
4cytosolGO:00582910.4CCND1, CA3, XIAP, PDZD11, CTNNB1, CDKN2A
5protein-DNA complexGO:03299310.2HMGA2, CTNNB1

Biological processes related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.8TP53, TP63, CCND1
2positive regulation of cell cycle arrestGO:07115810.8TP53, HMGA2, CDKN2A
3positive regulation of transcription, DNA-dependentGO:04589310.7CCNA2, CTNNB1, CDKN2A, HMGA2, TP63, TP53
4response to X-rayGO:01016510.7CCND1, TP63, TP53
5senescence-associated heterochromatin focus assemblyGO:03598610.7HMGA2, CDKN2A
6embryonic limb morphogenesisGO:03032610.7CTNNB1, GDF5, TP63
7positive regulation of cellular senescenceGO:200077410.7CDKN2A, HMGA2
8negative regulation of immature T cell proliferation in thymusGO:03308810.6CDKN2A, ERBB2
9negative regulation of transcription, DNA-dependentGO:04589210.6CTNNB1, CDKN2A, HMGA2, TP63, TP53
10mitotic G2 DNA damage checkpointGO:00709510.6HMGA2, CCNA2
11Ras protein signal transductionGO:00726510.5CCNA2, CDKN2A, TP53
12DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.5TP53, TP63
13positive regulation of apoptotic processGO:04306510.4TP53, HMGA2, CTNNB1, S100B
14replicative senescenceGO:09039910.2TP53, CDKN2A

Molecular functions related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.6TP53, CCND1, CCNA2, XIAP, S100B, PDZD11
2RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:00107710.5PLAGL2, HMGA2, TP63, TP53
3protein kinase bindingGO:01990110.5TP53, CDKN2A, CTNNB1, CCNA2, CCND1
4transcription factor bindingGO:00813410.5TP53, HMGA2, CDKN2A, CTNNB1
5MDM2/MDM4 family protein bindingGO:09737110.4CDKN2A, TP53
6p53 bindingGO:00203910.2TP53, TP63, CDKN2A

Products for genes affiliated with Pleomorphic Adenoma

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Sources for Pleomorphic Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet