MCID: PLM014
MIFTS: 63

Pleomorphic Adenoma malady

Cancer diseases, Oral diseases, Endocrine diseases categories
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Summaries for Pleomorphic Adenoma

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Wikipedia:65 Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation... more...

MalaCards based summary: Pleomorphic Adenoma, also known as mixed tumor of the salivary gland, is related to myoepithelioma and adenoma. An important gene associated with Pleomorphic Adenoma is DENR (density-regulated protein), and among its related pathways are IL-2 Gene Expression in Activated and Quiescent T-Cells and Inhibition of Ribosome Biogenesis by p14(ARF). The compounds lovastatin and olomoucine have been mentioned in the context of this disorder. Affiliated tissues include the salivary gl, salivary gland and breast, and related mouse phenotypes are limbs/digits/tail and nervous system.

Disease Ontology:8 A gastrointestinal benign neoplasm that is a located in the salivary glands.

Description from OMIM:46 181030

Aliases & Classifications for Pleomorphic Adenoma

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 44Novoseek, 46OMIM, 39NCIt, 34MeSH, 57SNOMED-CT
See all sources

Pleomorphic Adenoma, Aliases & Descriptions:

Name: Pleomorphic Adenoma 8 10
Mixed Tumor of the Salivary Gland 8 62
 
Mixed Salivary Gland Tumor 62
Adenoma Pleomorphic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Oral diseases, Endocrine diseases


External Ids:

Disease Ontology8 DOID:452
OMIM46 181030
SNOMED-CT57 8360001
MeSH34 D008949

Related Diseases for Pleomorphic Adenoma

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Diseases related to Pleomorphic Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1myoepithelioma31.2S100B, TP63
2adenoma31.0TP63, TP53, CCNA2, CCND1, CDKN2A, CD44
3chronic lymphocytic leukemia30.3XIAP, CCND1, CCNA2
4breast cancer30.2CTNNB1, ERBB2, CCND1
5neuroendocrine carcinoma30.0TP63, S100B
6basal cell carcinoma29.6CTNNB1, CD44, TP53, TP63
7sarcoma29.6TP63, TP53, CCNA2, S100B
8retinoblastoma29.6TP53, CCNA2, CCND1, ERBB2, CDKN2A
9astrocytoma29.6TP53, CCNA2, S100B, CDKN2A, CD44
10leukemia29.4TP53, CCNA2, CCND1, XIAP, CDKN2A, CD44
11adenocarcinoma29.3TP63, TP53, CCNA2, CCND1, ERBB2, XIAP
12lung cancer29.3TP63, TP53, CCNA2, ERBB2, XIAP, CD44
13melanoma28.6TP63, TP53, CCNA2, CCND1, S100B, XIAP
14adenoiditis10.7
15mucoepidermoid carcinoma10.6
16pleomorphic adenoma carcinoma10.6
17nasopharyngitis10.5
18epithelial-myoepithelial carcinoma10.4
19polymorphous low-grade adenocarcinoma10.4
20salivary gland tumor10.4
21turcot syndrome10.4CTNNB1
22gemistocytic astrocytoma10.4S100B
23syringoma10.4
24mixed lacrimal gland cancer10.4
25meningioma10.4S100B
26fasciitis10.3
27gallbladder adenoma10.3CDKN2A, CTNNB1
28neuroblastoma10.3TP53
29chordoma10.2
30lipoma10.2
31otitis media10.2
32thyroiditis10.2
33choroid plexus papilloma10.2TP53
34phyllode tumor10.2TP63, CCNA2
35smooth muscle tumor10.2CCNA2, S100B
36ganglioneuroblastoma10.2CD44, S100B
37multiple myeloma10.2CCND1, CD44
38malignant peripheral nerve sheath tumor10.2S100B, CDKN2A
39burkitt's lymphoma10.2CD44, XIAP, CCNA2
40breast fibroadenoma10.1TP63, ERBB2
41cervical squamous cell carcinoma10.1TP63, CDKN2A
42ganglioneuroma10.1CD44, S100B
43malignant fibroxanthoma10.1CCNA2, S100B
44oropharyngeal cancer, adult10.1CDKN2A, TP53
45tongue squamous cell carcinoma10.1CD44, CCND1, CCNA2
46large cell carcinoma10.1ERBB2, TP63
47li-fraumeni syndrome10.1TP53, CDKN2A
48gastric adenocarcinoma10.1CD44, ERBB2, CTNNB1
49nasopharynx carcinoma10.1TP53, CDKN2A
50asthma10.1

Graphical network of the top 20 diseases related to Pleomorphic Adenoma:



Diseases related to pleomorphic adenoma

Symptoms for Pleomorphic Adenoma

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Clinical features from OMIM:

181030

Drugs & Therapeutics for Pleomorphic Adenoma

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Drug clinical trials:

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Search NIH Clinical Center for Pleomorphic Adenoma

Genetic Tests for Pleomorphic Adenoma

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Anatomical Context for Pleomorphic Adenoma

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MalaCards organs/tissues related to Pleomorphic Adenoma:

32
Salivary gland, Breast, Trachea, Bone, Lung, Tongue, Smooth muscle, Kidney, Thyroid, Skin, Lymph node, Testes

FMA organs/tissues related to Pleomorphic Adenoma:

14
The salivary gl

Animal Models for Pleomorphic Adenoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Adenoma:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053717.7TP63, TP53, ERBB2, XIAP, CD44, CTNNB1
2MP:00036317.5CTNNB1, CD44, CDKN2A, ERBB2, CCND1, TP53
3MP:00053807.4TP63, TP53, CCNA2, ERBB2, CDKN2A, CTNNB1
4MP:00053917.4TP63, TP53, CCND1, CDKN2A, CD44, CTNNB1
5MP:00053697.4TP63, TP53, ERBB2, XIAP, CDKN2A, CD44
6MP:00053827.4TP63, TP53, CCND1, ERBB2, CTNNB1
7MP:00053977.3TP53, CCNA2, CCND1, XIAP, CDKN2A, CD44
8MP:00020067.3TP63, TP53, CCND1, ERBB2, CDKN2A, CD44
9MP:00053887.2TP63, TP53, CCND1, ERBB2, CDKN2A, CD44
10MP:00053817.2TP63, TP53, CCND1, ERBB2, CDKN2A, CD44
11MP:00053857.1TP63, TP53, CCND1, ERBB2, XIAP, CD44
12MP:00053797.0TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
13MP:00053907.0TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
14MP:00053896.9TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
15MP:00053876.9TP63, TP53, CCNA2, CCND1, XIAP, CDKN2A
16MP:00053786.8TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
17MP:00028736.8TP63, TP53, CCND1, S100B, ERBB2, XIAP
18MP:00053766.7TP63, TP53, CCND1, ERBB2, XIAP, CDKN2A
19MP:00053846.6TP63, TP53, CCNA2, CCND1, ERBB2, XIAP
20MP:00107686.5TP63, TP53, CCNA2, CCND1, ERBB2, XIAP
21MP:00107716.5CTNNB1, TP63, TP53, CCND1, S100B, ERBB2
22MP:00053866.4TP63, TP53, CCND1, S100B, ERBB2, XIAP

Publications for Pleomorphic Adenoma

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Articles related to Pleomorphic Adenoma:

(show top 50)    (show all 648)
idTitleAuthorsYear
1
MRI criteria for the diagnosis of pleomorphic adenoma: a validation study. (25128908)
2014
2
Nasopharyngeal pleomorphic adenoma presenting as otitis media with effusion: case report and literature review. (24051236)
2014
3
Surgical management of pleomorphic adenoma of parotid gland in elderly patients: Role of morphological features. (25159550)
2014
4
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. (24121173)
2013
5
Lacrimal gland pleomorphic adenoma: an inconceivable diagnosis in a child. (23667244)
2013
6
Salivary gland pleomorphic adenoma with giant cell tumor component. (23349467)
2013
7
Lacrimal gland pleomorphic adenoma masquerading as thyroid-associated ophthalmopathy. (23514669)
2013
8
Imaging findings of parapharyngeal space pleomorphic adenoma in comparison with parotid gland pleomorphic adenoma. (23990367)
2013
9
A rare case of nasopharyngeal pleomorphic adenoma. (23738174)
2013
10
Ectopic pleomorphic adenoma. (22536563)
2012
11
Lacrimal gland pleomorphic adenoma. (22656910)
2012
12
Chromosomal aberrations in minor salivary gland pleomorphic adenoma. (22695012)
2012
13
Pleomorphic adenoma in ectopic salivary gland tissue in the neck. (23397772)
2012
14
Carcinoma ex pleomorphic adenoma of the parotid gland. (22287150)
2012
15
Invasive salivary duct carcinoma ex pleomorphic adenoma of the parotid gland: a teaching case giving rise to the genuine diagnostic difficulty on an inadequate cytology specimen. (22647549)
2012
16
Pleomorphic adenoma of the lower lip: A rare site of location. (22540103)
2011
17
Increased mucin 1 expression in recurrence and malignant transformation of salivary gland pleomorphic adenoma. (21323961)
2011
18
Stepwise regional and distant progression of recurrent pleomorphic adenoma. (21303593)
2011
19
Immunohistochemical expression of progesterone receptors in pleomorphic adenoma and adenoid cystic carcinoma. (21546738)
2011
20
Pleomorphic adenoma of nasal septum: a case report. (20420081)
2010
21
Multicentric recurrent parotid pleomorphic adenoma in a child. (20173712)
2010
22
Immunohistochemical expression of estrogens and progesterone receptors in carcinoma ex pleomorphic adenoma-undifferentiated and adenocarcinoma types. (20038908)
2010
23
Pleomorphic adenoma of the main bronchus in an adult treated using a wedge bronchiectomy. (19160012)
2009
24
Primary pleomorphic adenoma of minor salivary gland in the parapharyngeal space. (19909506)
2009
25
Tumoral mass presenting in the nasomalar region arising from the lateral nasal wall: pleomorphic adenoma. (17549505)
2007
26
Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. (17881995)
2007
27
Imaging characteristics of recurrent pleomorphic adenoma of the parotid gland. (17846206)
2007
28
Interesting Case: Maxillary swing approach for resection of a large pleomorphic adenoma arising in the soft palate. (16055235)
2006
29
Lipomatous pleomorphic adenoma of the ceruminous gland. (16398681)
2006
30
Carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma. (16086968)
2005
31
Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature. (15991841)
2005
32
Pleomorphic adenoma of the breast: case report and review of the literature. (16299746)
2005
33
Loss of heterozygosity occurs predominantly, but not exclusively, in the epithelial compartment of pleomorphic adenoma. (16026648)
2005
34
Salivary gland-type mixed tumor (pleomorphic adenoma) of the lung. (17670335)
2004
35
Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. (12406304)
2002
36
Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas. (11894114)
2002
37
Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. (11431714)
2001
38
Histologic localization of PLAG1 (pleomorphic adenoma gene 1) in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells. (11555676)
2001
39
Pleomorphic adenoma gene 1 is expressed in cultured benign and malignant salivary gland tumor cells. (10334569)
1999
40
Immunohistochemical localization of fibroblast growth factors (FGFs) and FGF receptor-1 in human normal salivary glands and pleomorphic adenomas. (9725564)
1998
41
Immunohistochemical demonstration of bone morphogenetic protein-2 and type II collagen in pleomorphic adenoma of salivary glands. (9725565)
1998
42
Myoepithelial carcinoma with predominance of plasmacytoid cells arising in a pleomorphic adenoma of the parotid gland. (9839176)
1998
43
Effects of acidic and basic fibroblast growth factors on cell proliferation in pleomorphic adenoma of the parotid gland. (9288226)
1997
44
DNA flow cytometry and glial fibrillary acidic protein reactivity in pleomorphic adenomas of the salivary glands. (8908307)
1996
45
Expression of keratin mRNAs and proteins in normal salivary epithelia and pleomorphic adenomas. (7506306)
1993
46
Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). (7907371)
1993
47
Pleomorphic adenoma (benign mixed tumor) of the trachea. (1329058)
1992
48
Immunohistochemical study of monomorphic adenoma (clear cell and basal cell) and pleomorphic adenoma of the parotid gland]. (1897371)
1991
49
Abundant dendritic cells express HLA-DR in pleomorphic adenomas. (1980169)
1990
50
Glial fibrillary acidic protein expression in pleomorphic adenoma of salivary gland: an immunoelectron microscopic study. (2192489)
1990

Variations for Pleomorphic Adenoma

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Expression for genes affiliated with Pleomorphic Adenoma

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Expression patterns in normal tissues for genes affiliated with Pleomorphic Adenoma

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Pathways for genes affiliated with Pleomorphic Adenoma

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Pathways related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CCND1, CCNA2
29.3TP53, CDKN2A
3
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.3CDKN2A, CCND1, CCNA2
4
Show member pathways
9.1TP53, CCND1
5
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1CTNNB1, ERBB2, CCND1
6
Show member pathways
9.0CDKN2A, CCNA2, TP53
7
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0TP53, ERBB2, XIAP
88.9TP53, CCNA2, CD44
98.9TP53, CDKN2A, CD44
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
8.9CTNNB1, XIAP, TP53
118.9TP53, CDKN2A, CTNNB1
128.8TP53, CCND1, XIAP
13
Show member pathways
8.8TP53, ERBB2, CTNNB1
148.8CCND1, CCNA2, TP53
158.8CCND1, CCNA2, TP53
16
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.8CCND1, CCNA2, TP53
178.8CCND1, CCNA2, TP53
18
Show member pathways
DNA damage response37
8.8TP53, CCND1, CDKN2A
19
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
8.8ERBB2, CCND1, TP53
20
Show member pathways
8.7CDKN2A, TP53, TP63
218.7TP53, CCND1, CTNNB1
228.7TP53, CCND1, CTNNB1
238.7CTNNB1, CCND1, TP53
24
Show member pathways
Wnt Signaling Pathway NetPath37
8.7CTNNB1, CCND1, TP53
258.7CTNNB1, CCND1, TP53
268.7CTNNB1, CCND1, TP53
27
Show member pathways
8.5CD44, CDKN2A, ERBB2, TP53
288.5CTNNB1, XIAP, ERBB2, TP53
29
Show member pathways
8.5TP53, CCNA2, CCND1, CDKN2A
30
Show member pathways
8.5TP53, CCNA2, CCND1, CDKN2A
31
Show member pathways
Cell cycle37
8.5TP53, CCNA2, CCND1, CDKN2A
328.5TP53, CCNA2, CCND1, CDKN2A
33
Show member pathways
8.5TP53, CCNA2, CCND1, CDKN2A
34
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.4CCND1, ERBB2, XIAP, CD44, CTNNB1
35
Show member pathways
8.4TP53, CCND1, ERBB2, CDKN2A
36
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
8.4TP63, TP53, XIAP, CDKN2A
378.3CTNNB1, CDKN2A, CCND1, TP53
38
Show member pathways
Signal transduction PTEN pathway60
8.3TP53, CCND1, ERBB2, CTNNB1
398.3TP53, CCND1, CD44, CTNNB1
40
Show member pathways
8.1TP53, CCNA2, CCND1, ERBB2, CDKN2A
41
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
8.1TP53, CCNA2, CCND1, XIAP, CTNNB1
428.0TP53, CCND1, XIAP, CDKN2A, CTNNB1
438.0TP53, CCNA2, CCND1, ERBB2, CTNNB1
44
Show member pathways
Signaling Pathways in Glioblastoma37
8.0TP53, CCND1, ERBB2, CDKN2A, CTNNB1
45
Show member pathways
8.0TP53, CCND1, ERBB2, CDKN2A, CTNNB1
467.9CTNNB1, CD44, ERBB2, CCND1, TP53
47
Show member pathways
7.8TP63, TP53, CCNA2, CCND1, CDKN2A
487.7TP53, CCND1, ERBB2, XIAP, CDKN2A, CTNNB1
49
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
7.5CTNNB1, CD44, CDKN2A, ERBB2, CCND1, TP53
507.4TP63, TP53, CCND1, ERBB2, CDKN2A, CD44

Compounds for genes affiliated with Pleomorphic Adenoma

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Compounds related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1lovastatin44 50 61 28 1112.9CCND1, CTNNB1, CDKN2A, XIAP, CCNA2
2olomoucine44 119.8CCNA2, TP53, CDKN2A, CCND1
3oxaliplatin44 50 1110.8XIAP, ERBB2, TP53, CCNA2
4depsipeptide448.7TP53, CCNA2, CCND1, CDKN2A
5suberoylanilide hydroxamic acid448.7ERBB2, TP53, CCND1, XIAP
6indole-3-carbinol448.7XIAP, CTNNB1, CCND1, TP53
7sulindac44 119.6TP53, CTNNB1, XIAP, CCND1
8crcs448.6TP53, CCND1, CDKN2A, CTNNB1
9docetaxel44 50 61 1111.6TP53, CDKN2A, ERBB2, XIAP, CCNA2
104-hydroxytamoxifen448.6CTNNB1, S100B, CCND1, ERBB2
11agar448.6CCND1, XIAP, CDKN2A, CTNNB1, ERBB2
12imatinib44 50 1110.6XIAP, ERBB2, CTNNB1, CCND1, S100B
13celecoxib44 61 28 50 24 1113.5CTNNB1, CCNA2, CCND1, ERBB2
14gemcitabine44 50 1110.5CCNA2, CCND1, XIAP, ERBB2, TP53
15bortezomib44 50 1110.5TP53, ERBB2, XIAP, CCND1
16thymidylate448.4CDKN2A, TP53, CCNA2, ERBB2, CCND1
17adpribose448.4CCNA2, TP53, CTNNB1, XIAP, CCND1
18curcumin448.2CCND1, TP53, XIAP, CTNNB1, ERBB2
195fluorouracil448.2TP53, CCNA2, ERBB2, XIAP, CDKN2A, CTNNB1
20flavopiridol44 119.2XIAP, TP53, CDKN2A, CCNA2, ERBB2, CCND1
21vincristine44 50 1110.2CD44, XIAP, CCND1, CCNA2, TP53, CDKN2A
22roscovitine448.1CDKN2A, CTNNB1, CCND1, XIAP, TP53, CCNA2
23mg 13244 619.1CDKN2A, TP53, CTNNB1, CCNA2, CCND1, XIAP
24resveratrol44 61 24 1111.1TP53, CCNA2, CTNNB1, XIAP, ERBB2, CCND1
25arsenite44 249.1CDKN2A, XIAP, TP53, CCNA2, CCND1, CTNNB1
26etoposide44 50 61 1111.1XIAP, CD44, ERBB2, TP53, CCNA2, S100B
27egcg448.1TP53, ERBB2, XIAP, CDKN2A, CCND1, CTNNB1
28dexamethasone44 50 28 1111.1XIAP, S100B, ERBB2, CCNA2, CDKN2A, CD44
29bromodeoxyuridine448.0CTNNB1, TP63, CCNA2, S100B, CCND1, CD44
30h2o2447.9XIAP, CTNNB1, ERBB2, CCNA2, TP53, CDKN2A
31tamoxifen44 50 28 1110.9TP53, CCNA2, CCND1, ERBB2, CD44, CTNNB1
32n acetylcysteine447.9CDKN2A, TP53, ERBB2, CCND1, CTNNB1
33butyrate447.7CCNA2, CTNNB1, CDKN2A, XIAP, CD44, TP53
34adriamycin447.7TP53, XIAP, ERBB2, CTNNB1, CD44, CCND1
35ly294002447.7XIAP, TP53, CCNA2, CD44, ERBB2, CCND1
36cycloheximide447.3CDKN2A, CD44, CTNNB1, CCND1, XIAP, ERBB2
37testosterone44 61 24 1110.3CCND1, CCNA2, S100B, TP63, ERBB2, CDKN2A
38steroid447.3TP63, S100B, CDKN2A, CCND1, CD44, CCNA2
39thymidine44 248.2CCND1, CD44, S100B, TP63, CTNNB1, TP53
40tyrosine447.1TP63, CCNA2, CCND1, S100B, CD44, ERBB2
41arginine447.0CTNNB1, CCNA2, TP53, TP63, S100B, ERBB2
42paclitaxel44 50 118.8TP53, CCNA2, CCND1, S100B, ERBB2, XIAP
43serine446.8S100B, ERBB2, XIAP, CDKN2A, CD44, CTNNB1
44doxorubicin44 50 118.8CTNNB1, CD44, CDKN2A, XIAP, CCND1, CCNA2
45cisplatin44 50 61 119.7TP63, TP53, CCNA2, CD44, CTNNB1, ERBB2
46retinoic acid44 247.6TP63, CTNNB1, S100B, CD44, CDKN2A, XIAP
47progesterone44 28 61 24 1110.5TP63, TP53, CCNA2, CCND1, S100B, CDKN2A
48estrogen446.5CTNNB1, TP63, TP53, CCNA2, CCND1, S100B
49paraffin446.2S100B, CCND1, CTNNB1, CCNA2, TP53, TP63
50vegf446.2TP53, CCNA2, CCND1, S100B, ERBB2, XIAP

GO Terms for genes affiliated with Pleomorphic Adenoma

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Cellular components related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.3CDKN2A, TP53
2basolateral plasma membraneGO:0163239.1ERBB2, CD44, CTNNB1
3nucleoplasmGO:0056547.5TP63, TP53, CCNA2, CCND1, CDKN2A, CTNNB1
4cytosolGO:0058297.1TP63, TP53, CCND1, XIAP, CDKN2A, CTNNB1
5cytoplasmGO:0057376.4CTNNB1, TP63, TP53, CCNA2, S100B, ERBB2
6nucleusGO:0056346.2TP63, TP53, CCNA2, CCND1, S100B, ERBB2

Biological processes related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of G2/M transition of mitotic cell cycleGO:01038910.2CDKN2A, CCNA2
2negative regulation of immature T cell proliferation in thymusGO:03308810.1CDKN2A, ERBB2
3regulation of angiogenesisGO:0457659.9ERBB2, CTNNB1
4replicative senescenceGO:0903999.7CDKN2A, TP53
5proximal/distal pattern formationGO:0099549.7TP63, CTNNB1
6Wnt signaling pathwayGO:0160559.6XIAP, CD44, CTNNB1
7hair follicle morphogenesisGO:0310699.6TP63, CTNNB1
8positive regulation of cell cycle arrestGO:0711589.6CDKN2A, TP53
9embryonic limb morphogenesisGO:0303269.4CTNNB1, TP63
10DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4TP53, TP63
11Ras protein signal transductionGO:0072659.4TP53, CCNA2, CDKN2A
12positive regulation of mesenchymal cell proliferationGO:0020539.3TP63, CTNNB1
13cell agingGO:0075699.3TP53, TP63
14T cell differentiation in thymusGO:0330779.3CTNNB1, TP53
15response to gamma radiationGO:0103329.2TP63, TP53
16intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.2TP53, TP63
17cellular response to UVGO:0346449.1TP63, TP53
18cellular response to DNA damage stimulusGO:0069749.1XIAP, CCND1, TP53
19neuron apoptotic processGO:0514029.0TP63, TP53
20mitotic G1 DNA damage checkpointGO:0315718.9CCND1, TP53, TP63
21response to X-rayGO:0101658.9CCND1, TP53, TP63
22Notch signaling pathwayGO:0072198.9CCND1, TP53, TP63
23negative regulation of apoptotic processGO:0430668.7TP63, TP53, XIAP, CD44
24negative regulation of transcription, DNA-templatedGO:0458928.6TP63, TP53, CDKN2A, CTNNB1
25apoptotic processGO:0069158.6TP63, TP53, XIAP, CTNNB1
26positive regulation of transcription from RNA polymerase II promoterGO:0459448.4TP63, TP53, CDKN2A, CTNNB1
27positive regulation of apoptotic processGO:0430658.4CTNNB1, S100B, TP53
28negative regulation of transcription from RNA polymerase II promoterGO:0001228.4TP63, TP53, CCND1, CTNNB1
29positive regulation of transcription, DNA-templatedGO:0458938.3TP63, TP53, CCNA2, CDKN2A, CTNNB1

Molecular functions related to Pleomorphic Adenoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.4CDKN2A, TP53
2damaged DNA bindingGO:0036849.0TP53, TP63
3protein phosphatase bindingGO:0199038.9CTNNB1, ERBB2, TP53
4p53 bindingGO:0020398.9CDKN2A, TP53, TP63
5transcription factor bindingGO:0081348.5TP53, CCND1, CDKN2A, CTNNB1
6transcription regulatory region DNA bindingGO:0442128.5CTNNB1, TP53, TP63
7enzyme bindingGO:0198998.4TP53, CCND1, CTNNB1
8protein kinase bindingGO:0199018.2TP53, CCNA2, CCND1, CDKN2A, CTNNB1
9identical protein bindingGO:0428028.1TP63, TP53, S100B, ERBB2
10protein bindingGO:0055155.7CTNNB1, DENR, TP63, TP53, CCNA2, CCND1

Products for genes affiliated with Pleomorphic Adenoma

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  • Antibodies
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Sources for Pleomorphic Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet