MCID: PLM016
MIFTS: 36

Pleomorphic Carcinoma malady

Category: Cancer diseases

Aliases & Classifications for Pleomorphic Carcinoma

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Aliases & Descriptions for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:5662
SNOMED-CT62 16741004
NCIt45 C4094

Summaries for Pleomorphic Carcinoma

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Disease Ontology:11 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary: Pleomorphic Carcinoma is related to agenesis and aplasia of uterine body and ureter adenocarcinoma. An important gene associated with Pleomorphic Carcinoma is NKX2-1 (NK2 Homeobox 1), and among its related pathways are Gastric Cancer Network 2 and Signaling mediated by p38-alpha and p38-beta. Affiliated tissues include lung, pancreas and breast, and related mouse phenotypes are Decreased substrate adherent cell growth and Increased cell death HMECs cells.

Related Diseases for Pleomorphic Carcinoma

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Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1agenesis and aplasia of uterine body10.3EGFR, NKX2-1
2ureter adenocarcinoma10.3EGFR, NKX2-1
3wolffian adnexal neoplasm10.2EGFR, TP53
4paternal uniparental disomy of chromosome 110.2EGFR, TP53
5brainstem intraparenchymal clear cell meningioma10.2EGFR, TP53
6acrodermatitis chronica atrophicans10.2ALK, TP53
7tmem70 defect10.2NKX2-1, TP53
8triple-receptor negative breast cancer10.2EGFR, PGR
9skin sarcoma10.2EGFR, PGR
10cervical lymphoepithelioma-like carcinoma10.2EGFR, PGR
11childhood embryonal testis carcinoma10.2EGFR, TP53
12kidney disease10.2NKX2-1, TP53
13nervous system hibernoma10.2EGFR, PGR
14fallopian tube papillary adenocarcinoma10.2ALK, TP53
15bone deterioration disease10.2NKX2-1, TP53
16spastic paraplegia 110.2EGFR, TP53
17basaloid squamous cell carcinoma10.2EGFR, PGR
18chronic monocytic leukemia10.2EGFR, TP53
19aortitis10.2PGR, TP53
20pericardium leiomyoma10.2PGR, TP53
21combined t cell and b cell immunodeficiency10.2EGFR, PGR
22camptomelic syndrome long limb type10.2KRT8, TP53
23anomalous left coronary artery from the pulmonary artery10.2EGFR, PGR
24breast ductal carcinoma10.2PGR, TP53
25duodenal obstruction10.2KRT8, NKX2-1
26acinar cell carcinoma10.2PGR, TP53
27lacrimal gland squamous cell carcinoma10.2KRT8, TP53
28classic congenital mesoblastic nephroma10.2PGR, TP53
29secondary hyperparathyroidism of renal origin10.2EGFR, TP53
30mental retardation, autosomal recessive 4910.2KRT8, TP53
31bone marrow cancer10.2NKX2-1, PGR
32villoglandular endometrial endometrioid adenocarcinoma10.2PGR, TP53
33vaginal adenosarcoma10.2PGR, TP53
34paraphimosis10.1PGR, TP53
35seminoma10.1PGR, TP53
36occipital encephalocele10.1KRT18, KRT8
37woolly hair, autosomal dominant10.1KRT18, KRT8
38proteus-like syndrome10.1KRT18, KRT8
39exudative glomerulonephritis10.1EGFR, NKX2-1, TP53
40male reproductive organ benign neoplasm10.1PGR, TP53
41ganglioneuroblastoma10.1EGFR, KRT8
42brachial plexus neuropathy10.1EGFR, NKX2-1, TP53
43central nervous system primitive neuroectodermal neoplasm10.1PGR, TP53
44bartholin's gland adenoid cystic carcinoma10.1KRT18, KRT8
45pulmonary fibrosis and/or bone marrow failure, telomere-related, 110.1EGFR, NKX2-1, TP53
46multicentric papillary thyroid carcinoma10.1EGFR, TP53
47pancreatic cystadenoma10.1ALK, EGFR, TP53
48pancreatic cancer10.1KRT8, TP53
49gastrointestinal system cancer10.1NKX2-1, PGR
50sclerosing hemangioma10.1EGFR, PGR

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to pleomorphic carcinoma

Symptoms & Phenotypes for Pleomorphic Carcinoma

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GenomeRNAi Phenotypes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00193-A-39.7ALK, EGFR, KIT
2GR00103-A-09.3EGFR, KRT18, PGR, TP53

MGI Mouse Phenotypes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

41 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.2ALK, EGFR, KIT, TP53
2MP:00053818.8EGFR, KIT, KRT8, NKX2-1, TP53
3MP:00053888.8ALK, EGFR, KIT, NKX2-1, TP53
4MP:00030128.8EGFR, KIT, NKX2-1, PGR, TP53
5MP:00107718.7ALK, EGFR, KIT, PGR, TP53
6MP:00053708.5EGFR, KIT, KRT18, KRT8, TP53
7MP:00053798.4ALK, EGFR, KIT, NKX2-1, PGR, TP53
8MP:00020068.4ALK, EGFR, KIT, NKX2-1, PGR, TP53
9MP:00053858.3EGFR, KIT, KRT8, NKX2-1, PGR, TP53
10MP:00053808.0EGFR, KIT, KRT18, KRT8, PGR, TP53
11MP:00053767.9ALK, EGFR, KIT, KRT8, NKX2-1, PGR
12MP:00053897.8ALK, EGFR, KIT, KRT8, NKX2-1, PGR
13MP:00053787.8ALK, EGFR, KIT, KRT18, KRT8, NKX2-1
14MP:00053907.5ALK, EGFR, KIT, NKX2-1, PGR, TP53
15MP:00107687.2ALK, EGFR, KIT, KRT18, KRT8, NKX2-1

Drugs & Therapeutics for Pleomorphic Carcinoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial of Radiotherapy and Panitumumab in Salivary Gland MalignanciesWithdrawnNCT00984217Phase 2

Search NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

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Anatomical Context for Pleomorphic Carcinoma

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MalaCards organs/tissues related to Pleomorphic Carcinoma:

36
Lung, Pancreas, Breast, Thyroid, Colon, Brain, Tongue

Publications for Pleomorphic Carcinoma

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Articles related to Pleomorphic Carcinoma:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Pseudoprogression" of Pulmonary Pleomorphic Carcinoma during Nivolumab Therapy. (27189927)
2016
2
Pleomorphic Carcinoma of the Colon: Morphological and Immunohistochemical Findings. (27462191)
2016
3
High co-expression of PD-L1 and HIF-1I+ correlates with tumour necrosis in pulmonary pleomorphic carcinoma. (27107327)
2016
4
Pemetrexed and bevacizumab-containing chemotherapy for pleomorphic carcinoma of the lung. (27073676)
2016
5
Pleomorphic Carcinoma of the Lung: Relationship Between CT Findings and Prognosis. (27144416)
2016
6
P1.27: A Clinicopathological Study of ResectedA Pulmonary Pleomorphic Carcinoma: Track: Advanced NSCLC. (27676513)
2016
7
A rare primary pulmonary tumor with difficult diagnosis: pleomorphic carcinoma. (27525610)
2016
8
Anaplastic Lymphoma Kinase (ALK) Rearrangement-positive Lung Cancer with Transformation to Pleomorphic Carcinoma. (26568007)
2015
9
Successful treatment of two consecutive cases of pulmonary pleomorphic carcinoma with platinum chemotherapy. (26722286)
2015
10
Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas. (26329973)
2015
11
Retrospective analysis of the efficacy of chemotherapy and molecular targeted therapy for advanced pulmonary pleomorphic carcinoma. (26682906)
2015
12
Clinicoradiological outcomes of 33 cases of surgically resected pulmonary pleomorphic carcinoma: correlation with prognostic indicators. (25994197)
2015
13
Tumor-related gene expression levels in pulmonary pleomorphic carcinoma. (26031756)
2015
14
A Rare Case of Pleomorphic Carcinoma of the Lung Harboring an Anaplastic Lymphoma Kinase (ALK) Rearrangement. (26521903)
2015
15
Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung. (26345631)
2015
16
Promising effect of chemotherapy with bevacizumab for patients with pulmonary pleomorphic carcinoma: Two case reports and a literature review. (26521107)
2015
17
Response to Crizotinib and Clinical Outcome in ALK-Rearranged Pulmonary Pleomorphic Carcinoma. (25898961)
2015
18
Clinicopathological analysis of pleomorphic carcinoma of the lung: diffuse ZEB1 expression predicts poor survival. (25479687)
2015
19
EGFR and KRAS mutations in pulmonary pleomorphic carcinoma and their correlation with clinicopathologic features. (26199566)
2015
20
Comparative analysis of tumor angiogenesis and clinical features of 55 cases of pleomorphic carcinoma and adenocarcinoma of the lung. (25550577)
2015
21
Bevacizumab for critical brain metastases in a patient with pulmonary pleomorphic carcinoma. (25130117)
2014
22
A case of synchronous double primary lung cancer presenting with pleomorphic carcinoma and adenocarcinoma. (25553415)
2014
23
Unexpectedly long intravenous and intracardiac extension of a small-sized pulmonary pleomorphic carcinoma. (25590004)
2014
24
Pulmonary Pleomorphic Carcinoma Metastasis to the Midfoot. (24840733)
2014
25
Sarcomatous Components May Predict Prognosis in Patients with Pulmonary Pleomorphic Carcinoma. (25423314)
2014
26
A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity. (25123545)
2014
27
Pleomorphic Carcinoma Showing Rapid Growth, Multiple Metastases, and Intestinal Perforation. (24492166)
2014
28
Pulmonary pleomorphic carcinoma detected as a result of pneumothorax and the subsequent occurrence of multiple cystic metastases. (25214846)
2014
29
Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung. (24846683)
2014
30
Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine. (25400187)
2014
31
Long-term survival in a case of pleomorphic carcinoma with a brain metastasis. (25566055)
2014
32
Pleomorphic carcinoma of breast: a case report and review of literature. (25197400)
2014
33
Recurrent intussusception caused by intestinal metastasis of pulmonary pleomorphic carcinoma. (24924845)
2014
34
Pulmonary pleomorphic carcinoma with multiple metastases to the right posterior knee complicated by paraneoplastic hypercalcemia. (24396467)
2014
35
Spindle Cell Component in Pleomorphic Carcinoma Showing Polypoid Growth in the Pulmonary Vein. (23903706)
2013
36
Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC. (23651662)
2013
37
Pulmonary pleomorphic carcinoma with rapid progression. (24532631)
2013
38
Long-term remission achieved via combined chemotherapy and radiotherapy in a non-resectable granulocyte colony-stimulating factor producing pleomorphic carcinoma of the lung. (24088763)
2013
39
Intussusception Caused by Intestinal Metastasis from Lung Pleomorphic Carcinoma. (23903709)
2013
40
Multiple Cytokines-Producing Pleomorphic Carcinoma of Lung with Metastasis to the Small Intestine. (24200664)
2013
41
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. (23696935)
2013
42
Clinicopathological characteristics of surgically resected pulmonary pleomorphic carcinoma. (22228848)
2012
43
Pleomorphic carcinoma of the breast with expression of macrophage markers: report of two cases. (22726069)
2012
44
Pulmonary pleomorphic carcinoma producing granulocyte-macrophage colony-stimulating factor: report of a case. (22068679)
2012
45
A case of pleomorphic carcinoma of the lung suspected from infectious bulla. (23087315)
2012
46
Tumor angiogenesis in 75 cases of pleomorphic carcinoma of the lung. (22843911)
2012
47
Resected pleomorphic carcinoma of the gallbladder. (23341796)
2012
48
Two consecutive cases of platinum-refractory pulmonary pleomorphic carcinoma that showed dramatic responses to MAID (mesna, doxorubicin, ifosfamide and dacarbazine) chemotherapy. (20926411)
2011
49
Radical resection of a pleomorphic carcinoma after relieving airway obstruction by the endobronchial snare method. (21484559)
2011
50
Pleomorphic carcinoma of the lung arising in a patient with Li-Fraumeni syndrome: report of a case. (21626334)
2011

Variations for Pleomorphic Carcinoma

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Expression for genes affiliated with Pleomorphic Carcinoma

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Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for genes affiliated with Pleomorphic Carcinoma

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GO Terms for genes affiliated with Pleomorphic Carcinoma

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Biological processes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cerebral cortex cell migrationGO:002179510.4EGFR, NKX2-1
2extrinsic apoptotic signaling pathwayGO:009719110.0KRT18, KRT8
3hepatocyte apoptotic processGO:009728410.0KRT18, KRT8
4peptidyl-tyrosine phosphorylationGO:00181089.5ALK, EGFR, KIT
5protein autophosphorylationGO:00467779.5ALK, EGFR, KIT
6phosphatidylinositol-mediated signalingGO:00480159.5EGFR, KIT, TP53
7regulation of cell proliferationGO:00421279.4ALK, EGFR, KIT
8transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071698.9ALK, EGFR, KIT

Molecular functions related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1signal transducer, downstream of receptor, with protein tyrosine kinase activityGO:00047169.7EGFR, KIT
2enzyme bindingGO:00198999.4EGFR, NKX2-1, PGR, TP53
3protein tyrosine kinase activityGO:00047139.3ALK, EGFR, KIT
4transmembrane receptor protein tyrosine kinase activityGO:00047148.9ALK, EGFR, KIT

Sources for Pleomorphic Carcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet