MCID: PLM016
MIFTS: 47

Pleomorphic Carcinoma malady

Cancer category

Summaries for Pleomorphic Carcinoma

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards: Pleomorphic Carcinoma is related to spindle cell carcinoma and large cell carcinoma. An important gene associated with Pleomorphic Carcinoma is KRT14 (keratin 14), and among its related pathways are EGFR Signaling Pathway and Akt Signaling Pathway . The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include ovary, tongue and lung, and related mouse phenotypes are muscle and tumorigenesis.

Aliases & Classifications for Pleomorphic Carcinoma

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

pleomorphic carcinoma 8 61


External Ids:

Disease Ontology8 DOID:5662
SNOMED-CT57 16741004
NCIt40 C4094

Related Diseases for Pleomorphic Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 229)
idRelated DiseaseScoreTop Affiliating Genes
1spindle cell carcinoma30.4MUC1, DES, VIM
2large cell carcinoma30.0NKX2-1, IVL, CGB5, EGFR
3bladder carcinoma29.9TP53, KRT8, KRT18, CAV1
4adenocarcinoma29.9TP53, GGT1, KRT8, KRT14, KRT18, FSCN1
5intussusception10.2
6clear cell adenocarcinoma10.0
7signet ring cell adenocarcinoma10.0
8small cell carcinoma10.0
9lung lymphoma10.0
10lung giant cell carcinoma10.0
11bladder signet ring cell adenocarcinoma10.0
12gynecomastia10.0
13hypercalcemia10.0
14bronchopneumonia10.0
15bladder adenocarcinoma10.0
16bladder clear cell adenocarcinoma10.0
17cerebral primitive neuroectodermal tumor10.0CD99
18keratosis10.0IVL
19epidermolysis bullosa10.0KRT14
20lichen planus10.0IVL
21pulmonary blastoma10.0NKX2-1
22dermatitis10.0IVL
23endometriosis10.0CALB2
24keratoacanthoma10.0IVL
25malignant peritoneal mesothelioma10.0CALB2
26histiocytosis10.0FSCN1
27graves' disease10.0NKX2-1
28cystadenocarcinoma10.0MUC1
29pheochromocytoma10.0CALB2
30molluscum contagiosum10.0IVL
31interstitial lung disease10.0MUC1
32pemphigus foliaceus10.0IVL
33hidradenoma10.0MUC1
34hepatoblastoma10.0KRT18
35sex cord-gonadal stromal tumor10.0CALB2
36infantile myofibromatosis10.0DES
37testicular cancer10.0CGB5
38hyperthyroidism10.0CGB5
39thymoma10.0NKX2-1, CALB2
40sarcoidosis10.0KRT8
41fibrous meningioma10.0MUC1
42cryptorchidism10.0CGB5
43hemangioma10.0NKX2-1, PDPN
44myoepithelioma10.0KRT14, VIM
45peritonitis10.0CRP
46pancreas disease10.0GGT1
47ischemia10.0CAV1
48primary hyperoxaluria10.0GGT1
49tonsillitis10.0CRP
50adenomatoid tumor10.0CALB2, VIM

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to pleomorphic carcinoma

Clinical Features for Pleomorphic Carcinoma

Drugs & Therapeutics for Pleomorphic Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pleomorphic Carcinoma

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Carcinoma

Search NIH Clinical Center for Pleomorphic Carcinoma

Search CenterWatch for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

Anatomical Context for Pleomorphic Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Pleomorphic Carcinoma:

33
Ovary, Tongue, Lung, Smooth muscle, Small intestine, Colon, Pancreas, Thyroid, Salivary gland, Breast, Prostate, T cells

Animal Models for Pleomorphic Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pleomorphic Carcinoma

Sources:
51PubMed
See all sources

Articles related to Pleomorphic Carcinoma:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
Carcinoma ex pleomorphic adenoma in the oral cavity: a huge oral cavity mass with neck metastasis. (24220462)
2013
2
Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin I+vI^3 in pleomorphic adenoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma. (24237725)
2013
3
Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC. (23651662)
2013
4
t(3;8) as the sole chromosomal abnormality in a myoepithelial carcinoma ex pleomorphic adenoma: a putative progression event. (22287457)
2013
5
Multiple Cytokines-Producing Pleomorphic Carcinoma of Lung with Metastasis to the Small Intestine. (24200664)
2013
6
Pathology quiz case 3. Carcinoma ex pleomorphic adenoma(CXPA), salivary duct carcinoma type, noninvasive. (22911312)
2012
7
Expression of p21 is dependent on or independent of p53 in carcinoma ex pleomorphic adenoma (undifferentiated and adenocarcinoma types). (23359201)
2012
8
Pleomorphic carcinoma of the breast with expression of macrophage markers: report of two cases. (22726069)
2012
9
HER-2/neu gene amplification in carcinoma ex pleomorphic adenoma in relation to progression and prognosis: a chromogenic in-situ hybridization study. (22486195)
2012
10
Colonic metastases from pleomorphic carcinoma of the lung presenting as an ileocecal intussusception. (21991496)
2011
11
Pleomorphic adenoma of the breast initially misdiagnosed as metaplastic carcinoma in preoperative stereotactic biopsy: a case report and review of the literature. (21941969)
2011
12
Basaloid squamous cell carcinoma with 'monster' cells: a mimic of pleomorphic basal cell carcinoma. (21039745)
2011
13
Two consecutive cases of platinum-refractory pulmonary pleomorphic carcinoma that showed dramatic responses to MAID (mesna, doxorubicin, ifosfamide and dacarbazine) chemotherapy. (20926411)
2011
14
Pleomorphic carcinoma of the lung with intrapulmonary aerogenic metastases on FDG PET. (20706051)
2010
15
Undifferentiated carcinoma with osteoclast-like giant cell tumor of the pancreas: a discussion of rare entity in comparison with pleomorphic giant cell tumor of the pancreas. (21045455)
2010
16
FGF-2 is overexpressed in myoepithelial cells of carcinoma ex-pleomorphic adenoma in situ structures. (20514456)
2010
17
Fine needle aspiration cytology of oncocytic myoepithelial carcinoma ex pleomorphic adenoma. (21053598)
2010
18
Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma, with emphasis on the carcinoma histologic subtype: a clinicopathologic study of 43 cases. (20338616)
2010
19
Immunohistochemical Expression of p53 in Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma. (21253477)
2010
20
Pleomorphic lymphoepithelioma-like carcinoma of the urinary bladder. (19079656)
2009
21
Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ of the breast. (19701073)
2009
22
Esophageal polypoidal mass: presentation of an uncommon pleomorphic carcinoma. (19750865)
2009
23
Expressions of androgen receptor and its co-regulators in carcinoma ex pleomorphic adenoma of salivary gland. (19672785)
2009
24
Pleomorphic carcinoma with osteoclastic giant cells of the breast: immunohistochemical differentiation between coexisting neoplastic and reactive giant cells. (19154262)
2009
25
Pleomorphic carcinoma of the lung in which the sarcomatous element grew rapidly: a case report. (19471225)
2009
26
Carcinoma ex pleomorphic adenoma in a minor salivary gland of the upper lip. (19836713)
2009
27
Collagen type I may influence the expression of E-cadherin and beta-catenin in carcinoma ex-pleomorphic adenoma. (19276972)
2009
28
Tumour-to-tumour metastasis from a carcinoma of the breast to a pleomorphic adenoma of the parotid gland. (19128698)
2008
29
Carcinoma ex pleomorphic adenoma of the parotid gland: radiologic-pathologic correlation with MR imaging including diffusion-weighted imaging. (18272554)
2008
30
Pleomorphic carcinoma of the lung: a report of six cases. (17978928)
2007
31
The spectrum of morphomolecular abnormalities of the E-cadherin/catenin complex in pleomorphic lobular carcinoma of the breast. (17721269)
2007
32
Desmoplasia in different degrees of invasion of carcinoma ex-pleomorphic adenoma. (20614261)
2007
33
Pulmonary pleomorphic carcinoma producing hCG. (17803660)
2007
34
Immunohistochemical expression of p63 in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands. (16256413)
2006
35
Carcinoma ex pleomorphic adenoma with sebaceous differentiation in the mandibular salivary gland of a dog. (16672588)
2006
36
Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation. (16273189)
2005
37
Pleomorphic rhabdomyosarcoma of the anterior abdominal wall following multimodality treatment for carcinoma of the rectum. (15173925)
2004
38
Resection of a pleomorphic carcinoma of the lung invading the descending aorta. (15173751)
2004
39
Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases. (12604887)
2003
40
E-cadherin expression in pleomorphic lobular carcinoma: an aid to differentiation from ductal carcinoma. (12478484)
2002
41
Epithelial-myoepithelial carcinoma arising in pleomorphic adenoma of the palate. (11027383)
2000
42
Pleomorphic lobular carcinoma: morphology, immunohistochemistry, and molecular analysis. (11117786)
2000
43
Mucoepidermoid carcinoma ex pleomorphic adenoma: nonspecific preoperative cytologic findings in six cases. (9723598)
1998
44
Deletion of the p16 gene and microsatellite instability in carcinoma arising in pleomorphic adenoma of the parotid gland. (9917133)
1998
45
Pleomorphic carcinoma of the pancreas: reappraisal of surgical resection. (9672350)
1998
46
Salivary epithelial-myoepithelial carcinoma: report of a case misinterpreted as pleomorphic adenoma on fine needle aspiration (FNA). (9202896)
1997
47
Surgical treatment of pleomorphic carcinoma of the pancreas. (2190511)
1990
48
Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells expressing an epithelial-associated antigen detected by monoclonal antibody 44-3A6. (3254809)
1988
49
Pleomorphic carcinoma of the thyroid. (20312831)
1977
50
Pleomorphic carcinoma of the pancreas: an analysis of 15 cases. (870168)
1977

Genetic Variations for Pleomorphic Carcinoma

Expression for genes affiliated with Pleomorphic Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pleomorphic Carcinoma

Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for genes affiliated with Pleomorphic Carcinoma

Sources:
56SinoBiological, 53R&D Systems, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Pleomorphic Carcinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1butyrate4510.5CALB2
2estrogen4510.2CALB2, IVL
3cycloheximide459.8KRT8, CAV1, CGB5
4forskolin45 50 1111.7KRT8, KRT18, VIM, IVL, NKX2-1
5dihydrotestosterone45 29 11 2412.6VIM, CDKN1B, DES, CGB5
6glycogen45 2410.5KRT8, KRT18, CDKN1B, CGB5
7mucicarmine459.5VIM, KRT14, MUC1, NKX2-1, DES, CALB2
8formaldehyde45 2410.5VIM, NKX2-1, KRT18, CDKN1B, MUC1, DES
9bromodeoxyuridine459.2KRT8, KRT14, CDKN1B, KRT18, DES, IVL
10progestin459.2CGB5, MUC1, DES, VIM, EGFR
11agar459.2VIM, KRT8, CDKN1B, MUC1, EGFR, CAV1
12creatinine459.1KRT18, GGT1, CGB5, CRP
13retinoid459.1TP53, KRT8, KRT14, KRT18, IVL, EGFR
14b 723459.0MUC1, KRT8, DES, PDPN, NKX2-1, CALB2
1512-o-tetradecanoylphorbol 13-acetate458.9MUC1, FSCN1, CDKN1B, DES, IVL, VIM
16gold458.9MUC1, IVL, DES, KRT18, CAV1, KRT8
17serine458.9CDKN1B, CAV1, DES, NKX2-1, FSCN1, KRT14
18tamoxifen45 50 29 1111.8EGFR, CDKN1B, KRT14, KRT8, GGT1, CGB5
19dexamethasone45 50 29 1111.8KRT18, CGB5, CAV1, GGT1, CDKN1B, NKX2-1
20adriamycin458.8MUC1, TP53, DES, CSF3, KRT8, VIM
21gemcitabine45 50 1110.8EGFR, CSF3, TP53, CDKN1B, MUC1
22cytarabine45 50 1110.7CSF3, MUC1, CDKN1B, TP53, VIM
23actinomycin d458.7VIM, TP53, KRT8, KRT18, CGB5, DES
24glucose458.7KRT14, CDKN1B, KRT18, KRT8, CAV1, CGB5
25urea45 11 2410.7CGB5, IVL, KRT18, KRT14, KRT8, GGT1
26threonine458.6DES, CAV1, KRT14, NKX2-1, MUC1, CDKN1B
27etoposide45 50 60 1111.6CDKN1B, CGB5, KRT8, CSF3, CAV1, VIM
28oligonucleotide458.6CAV1, VIM, NKX2-1, CDKN1B, KRT18, KRT8
29steroid458.6NKX2-1, CGB5, KRT18, KRT8, CALB2, DES
30dmso458.5VIM, CSF3, CGB5, MUC1, CDKN1B, KRT18
31n acetylcysteine458.5GGT1, CRP, CDKN1B, EGFR, KRT18, TP53
325fluorouracil458.4EGFR, MUC1, CDKN1B, IVL, CSF3, KRT18
33cyclophosphamide45 50 1110.4CSF3, CRP, CDKN1B, KRT18, TP53, CGB5
34ethanol45 50 11 2411.3GGT1, CGB5, KRT8, KRT18, MUC1, DES
35iron45 249.3CRP, VIM, CAV1, IVL, DES, KRT18
36hematoxylin458.3KRT8, KRT14, KRT18, NKX2-1, DES, PDPN
37lactate458.2IVL, CGB5, CRP, DES, KRT8, GGT1
38thymidine45 249.1CSF3, IVL, CALB2, KRT18, DES, MUC1
39paclitaxel45 50 119.8CALB2, CAV1, CDKN1B, KRT8, TP53, CSF3
40methotrexate45 50 119.7CDKN1B, CGB5, IVL, MUC1, CRP, VIM
41arginine457.7CAV1, GGT1, KRT14, CDKN1B, DES, CGB5
42lipid457.6KRT8, CGB5, KRT14, KRT18, MUC1, CRP
43doxorubicin45 50 119.6EGFR, CSF3, CAV1, KRT18, VIM, CGB5
44progesterone45 60 29 11 2411.5VIM, CALB2, CAV1, EGFR, CGB5, DES
45testosterone45 60 11 2410.3CGB5, DES, MUC1, GGT1, KRT8, KRT18
46cisplatin45 50 60 1110.3EGFR, CSF3, CAV1, CGB5, MUC1, CDKN1B
47retinoic acid45 247.3VIM, CAV1, CSF3, EGFR, CGB5, IVL
48vegf456.0TP53, KRT8, VIM, CAV1, PDPN, CSF3
49paraffin456.0DES, CD99, MUC1, NKX2-1, IVL, CGB5
50tyrosine456.0IVL, CGB5, EGFR, CSF3, PDPN, CAV1

GO Terms for genes affiliated with Pleomorphic Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.8KRT8, KRT14, KRT18
2intermediate filamentGO:0058829.4KRT8, KRT14, KRT18, DES, VIM
3filopodiumGO:0301759.3PDPN, CRP, FSCN1
4cytoplasmGO:0057377.3VIM, CALB2, EGFR, IVL, MUC1, CD99

Biological processes related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycle arrestGO:07185010.0TP53, CDKN1B
2response to ischemiaGO:0029319.9TP53, CAV1
3cerebral cortex cell migrationGO:0217959.7NKX2-1, EGFR
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.7MUC1, CDKN1B, TP53
5modulation by virus of host morphology or physiologyGO:0190489.3TP53, KRT8, KRT18, CAV1, VIM

Molecular functions related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.9KRT14, DES, VIM
2scaffold protein bindingGO:0971109.9KRT8, KRT18, VIM
3structural molecule activityGO:0051989.3CAV1, IVL, KRT18, KRT8
4enzyme bindingGO:0198998.5TP53, EGFR, CSF3, CAV1
5protein bindingGO:0055156.7NKX2-1, DES, EGFR, CRP, CAV1, VIM

Products for genes affiliated with Pleomorphic Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pleomorphic Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet