MCID: PLM016
MIFTS: 42

Pleomorphic Carcinoma malady

Cancer diseases category
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Summaries for Pleomorphic Carcinoma

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Disease Ontology:8 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary: Pleomorphic Carcinoma is related to adenocarcinoma and syringoma. An important gene associated with Pleomorphic Carcinoma is KRT14 (keratin 14), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Cell adhesion Integrin mediated cell adhesion and migration. The compounds b 723 and urea have been mentioned in the context of this disorder. Affiliated tissues include lung, pancreas and breast, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Pleomorphic Carcinoma

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Pleomorphic Carcinoma, Aliases & Descriptions:

Name: Pleomorphic Carcinoma 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:5662
SNOMED-CT57 16741004
NCIt39 C4094

Related Diseases for Pleomorphic Carcinoma

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Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma29.5KRT18, KRT14, NKX2-1, CAV1
2syringoma10.4KRT14
3intussusception10.3
4angiosarcoma10.2KRT14, KRT18
5ameloblastoma10.2KRT18, KRT14
6intestinal perforation10.2
7thyroiditis10.2
8thymus cancer10.2KRT18, NKX2-1
9epidermolysis bullosa simplex10.2KRT14, DES
10neuroendocrine carcinoma10.2NKX2-1, KRT18
11transitional cell carcinoma10.1KRT18, KRT14
12synovial sarcoma10.1KRT14, DES
13sex cord-gonadal stromal tumor10.1DES, NKX2-1
14abrikosov's tumor10.1DES, NKX2-1
15malignant mesothelioma10.1NKX2-1, DES
16non-small cell lung carcinoma10.1NKX2-1, KRT18
17wilms tumor10.1NKX2-1, DES
18factor v leiden thrombophilia10.0KRT14, NKX2-1
19gynecomastia10.0
20hypercalcemia10.0
21large cell carcinoma10.0
22small cell carcinoma10.0
23bronchopneumonia10.0
24spindle cell carcinoma10.0
25esophagitis10.0
26mediastinitis10.0
27pneumothorax10.0
28oral cancer10.0CAV1, KRT14
29cork-handlers' disease10.0KRT18, NKX2-1
30bladder carcinoma10.0CAV1, KRT18
31papillary thyroid carcinoma10.0NKX2-1, CAV1
32squamous cell carcinoma of the head and neck10.0KRT18, KRT14
33papillary carcinoma10.0NKX2-1, KRT14, KRT18
34chordoma10.0KRT18, KRT14, DES
35breast cancer10.0KRT14, CAV1
36pleomorphic adenoma10.0KRT18, KRT14, DES
37noonan syndrome9.9CAV1, DES
38oxyphilic adenoma9.9CAV1, KRT14, KRT18
39fibrosarcoma9.9DES, CAV1
40psoriasis9.8KRT18, KRT14, CAV1
41retinoblastoma9.8CAV1, KRT14, KRT18
42muscular dystrophy9.8DES, CAV1, KRT14
43lung adenocarcinoma9.8KRT18, NKX2-1, CAV1
44colorectal cancer9.8CAV1, KRT14, KRT18
45liver cirrhosis9.8KRT18, CAV1
46lung small cell carcinoma9.6CAV1, NKX2-1, KRT14, KRT18
47kidney cancer9.6KRT18, KRT14, NKX2-1, CAV1
48adenoma9.6KRT18, KRT14, NKX2-1, CAV1
49liver cancer9.6CAV1, NKX2-1, KRT14, KRT18
50lung cancer9.6CAV1, NKX2-1, KRT14, KRT18

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to pleomorphic carcinoma

Symptoms for Pleomorphic Carcinoma

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Drugs & Therapeutics for Pleomorphic Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Pleomorphic Carcinoma

Search NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

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Anatomical Context for Pleomorphic Carcinoma

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MalaCards organs/tissues related to Pleomorphic Carcinoma:

32
Lung, Pancreas, Breast, Thyroid, Brain, Small intestine, Colon, Tongue

Animal Models for Pleomorphic Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7CAV1, NKX2-1, KRT14
2MP:00053818.7KRT14, NKX2-1, CAV1
3MP:00053888.4KRT14, NKX2-1, CAV1
4MP:00053788.1CAV1, NKX2-1, KRT14, KRT18
5MP:00107687.6KRT18, KRT14, NKX2-1, CAV1, DES

Publications for Pleomorphic Carcinoma

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Articles related to Pleomorphic Carcinoma:

(show top 50)    (show all 90)
idTitleAuthorsYear
1
Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung. (24846683)
2014
2
A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity. (25123545)
2014
3
Bevacizumab for critical brain metastases in a patient with pulmonary pleomorphic carcinoma. (25130117)
2014
4
Recurrent intussusception caused by intestinal metastasis of pulmonary pleomorphic carcinoma. (24924845)
2014
5
Pulmonary pleomorphic carcinoma with rapid progression. (24532631)
2013
6
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. (23696935)
2013
7
Long-term remission achieved via combined chemotherapy and radiotherapy in a non-resectable granulocyte colony-stimulating factor producing pleomorphic carcinoma of the lung. (24088763)
2013
8
Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC. (23651662)
2013
9
Resected pleomorphic carcinoma of the gallbladder. (23341796)
2012
10
Tumor angiogenesis in 75 cases of pleomorphic carcinoma of the lung. (22843911)
2012
11
Colonic metastases from pleomorphic carcinoma of the lung presenting as an ileocecal intussusception. (21991496)
2011
12
Pleomorphic carcinoma of the lung with intrapulmonary aerogenic metastases on FDG PET. (20706051)
2010
13
Clinical characteristics of pleomorphic carcinoma of the lung. (19577320)
2010
14
Pulmonary pleomorphic carcinoma: a clinicopathological study including EGFR mutation analysis. (20107421)
2010
15
Pulmonary pleomorphic carcinoma: diagnosis using small biopsy specimens. (20736811)
2010
16
Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia. (21165299)
2010
17
Genetic heterogeneity of EGFR mutation in pleomorphic carcinoma of the lung: response to gefitinib and clinical outcome. (19155283)
2009
18
The role of palliative chemotherapy for advanced pulmonary pleomorphic carcinoma. (18989796)
2009
19
Esophageal polypoidal mass: presentation of an uncommon pleomorphic carcinoma. (19750865)
2009
20
Pleomorphic carcinoma of the lung with uncommon initial manifestation of intestinal perforation]. (19601528)
2009
21
Pleomorphic carcinoma with osteoclastic giant cells of the breast: immunohistochemical differentiation between coexisting neoplastic and reactive giant cells. (19154262)
2009
22
Pleomorphic carcinoma of the lung in which the sarcomatous element grew rapidly: a case report. (19471225)
2009
23
Two cases of pleomorphic carcinoma with severe systemic inflammation]. (19764522)
2009
24
Pleomorphic carcinoma of the lung: clinicopathologic characteristics of 70 cases. (18769330)
2008
25
Pleomorphic carcinoma of the lung expressing podoplanin and calretinin. (19067851)
2008
26
Long-term survival in two cases of resected gastric metastasis of pulmonary pleomorphic carcinoma. (18594328)
2008
27
Pleomorphic carcinoma of the lung: a report of six cases. (17978928)
2007
28
Expression of caveolin-1 in pleomorphic carcinoma of the lung is correlated with a poor prognosis. (16334154)
2005
29
Pleomorphic carcinoma of the lung associated with loss of heterozygosity of p53 gene. (15888975)
2005
30
Pleomorphic carcinoma of the lung with mediastinal extension following malignant lymphoma: report of a case. (16249854)
2005
31
Personal experience in surgical management of pulmonary pleomorphic carcinoma. (15511465)
2004
32
Metastatic pleomorphic carcinoma of lung presenting as abdominal pain. (15622698)
2004
33
Pleomorphic carcinoma of lung: comparison of CT features and pathologic findings. (15215543)
2004
34
Resection of a pleomorphic carcinoma of the lung invading the descending aorta. (15173751)
2004
35
Pleomorphic carcinomas of the lung show a selective distribution of gene products involved in cell differentiation, cell cycle control, tumor growth, and tumor cell motility: a clinicopathologic and immunohistochemical study of 31 cases. (12960804)
2003
36
Pleomorphic carcinoma of the breast: clinicopathological analysis of 26 cases of an unusual high-grade phenotype of ductal carcinoma. (10849092)
2000
37
Pathological study of the pleomorphic carcinoma of the lung]. (11866944)
2000
38
Pleomorphic carcinoma of the pancreas: reappraisal of surgical resection. (9672350)
1998
39
A case of pleomorphic carcinoma of the pancreas showing sequential histological change by immunohistochemical study. (7594772)
1995
40
Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells. (8113629)
1993
41
Pleomorphic carcinoma of the gallbladder: report of a case. (1803718)
1991
42
Surgical treatment of pleomorphic carcinoma of the pancreas. (2190511)
1990
43
Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells expressing an epithelial-associated antigen detected by monoclonal antibody 44-3A6. (3254809)
1988
44
Pleomorphic carcinoma of the pancreas: computed-tomographic, sonographic, and pathologic findings. (3880902)
1985
45
Pleomorphic carcinoma of the gallbladder: case report and ultrastructural study. (6539521)
1984
46
Pleomorphic carcinoma of the thyroid. (20312831)
1977
47
A functioning pleomorphic carcinoma of the thyroid. (1277059)
1976
48
Pleomorphic carcinoma of the larynx. (5643249)
1968
49
Total pancreatectomy for pleomorphic carcinoma. A five-year cure. (5902860)
1966
50
FOUR SEPARATE TUMOUR CLONES DERIVED FROM A TRANSPLANTABLE PLEOMORPHIC CARCINOMA OF THE LUNG IN A HETEROZYGOUS MOUSE. (14263471)
1965

Variations for Pleomorphic Carcinoma

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Expression for genes affiliated with Pleomorphic Carcinoma

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Expression patterns in normal tissues for genes affiliated with Pleomorphic Carcinoma

Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for genes affiliated with Pleomorphic Carcinoma

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Pathways related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5KRT18, KRT14
2
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.1NKX2-1, CAV1
39.1KRT18, CAV1
48.5KRT18, CAV1, DES

Compounds for genes affiliated with Pleomorphic Carcinoma

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Compounds related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1b 723449.6DES, NKX2-1
2urea44 24 1111.6KRT18, KRT14
3p002449.4DES, KRT18
4ganglioside449.3CAV1, DES
5mucicarmine449.3DES, NKX2-1, KRT14
6bromodeoxyuridine449.2DES, KRT14, KRT18
7formaldehyde44 2410.1KRT18, NKX2-1, DES
8egcg449.1KRT18, CAV1
9phosphatidylserine44 28 1111.1KRT18, CAV1
10oligonucleotide448.9KRT18, NKX2-1, CAV1
11gold448.9KRT18, CAV1, DES
12dexamethasone44 50 28 1111.8CAV1, NKX2-1, KRT18
13alanine448.8KRT18, KRT14, CAV1
14doxorubicin44 50 1110.8KRT18, CAV1, DES
15fatty acid448.8KRT18, CAV1, DES
16testosterone44 61 24 1111.8DES, CAV1, KRT18
17arginine448.8KRT14, CAV1, DES
18hematoxylin448.8KRT18, KRT14, NKX2-1, DES
19vegf448.7KRT18, CAV1, DES
20nitric oxide44 24 1110.7DES, CAV1, KRT18
21iron44 249.4KRT18, KRT14, CAV1, DES
22oxygen44 249.4DES, CAV1, KRT18
23glucose448.4DES, CAV1, KRT14, KRT18
24steroid448.3DES, CAV1, NKX2-1, KRT18
25cysteine448.3KRT14, CAV1, DES
26paraffin447.9DES, CAV1, NKX2-1, KRT14, KRT18
27progesterone44 28 61 24 1111.9KRT18, KRT14, NKX2-1, CAV1, DES
28threonine447.9KRT18, KRT14, NKX2-1, CAV1, DES
29estrogen447.9DES, CAV1, NKX2-1, KRT14, KRT18
30retinoic acid44 248.9DES, CAV1, NKX2-1, KRT14, KRT18
31serine447.9DES, CAV1, NKX2-1, KRT14, KRT18
32tyrosine447.9DES, CAV1, NKX2-1, KRT14, KRT18

GO Terms for genes affiliated with Pleomorphic Carcinoma

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Cellular components related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.5KRT18, KRT14
2intermediate filamentGO:0058828.6KRT18, KRT14, DES

Molecular functions related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.3KRT14, DES
2structural molecule activityGO:0051989.1KRT18, CAV1
3protein bindingGO:0055157.2KRT18, KRT14, NKX2-1, CAV1, DES

Products for genes affiliated with Pleomorphic Carcinoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Pleomorphic Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet