MCID: PLM016
MIFTS: 39

Pleomorphic Carcinoma malady

Category: Cancer diseases

Aliases & Classifications for Pleomorphic Carcinoma

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Aliases & Descriptions for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:5662
SNOMED-CT59 16741004
NCIt42 C4094
UMLS65 C0334233

Summaries for Pleomorphic Carcinoma

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Disease Ontology:10 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary: Pleomorphic Carcinoma is related to embryoma and lymphatic system disease. An important gene associated with Pleomorphic Carcinoma is EGFR (Epidermal Growth Factor Receptor), and among its related pathways are Bladder cancer and Gastric cancer network 2. Affiliated tissues include salivary gland, liver and lung, and related mouse phenotypes are adipose tissue and limbs/digits/tail.

Related Diseases for Pleomorphic Carcinoma

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Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1embryoma30.3EGFR, TP53
2lymphatic system disease10.4EGFR, TP53
3hypogonadotropic hypogonadism-frontoparietal alopecia syndrome10.4EGFR, TP53
4cervical non-keratinizing squamous cell carcinoma10.4EGFR, TP53
5high molecular weight kininogen deficiency10.4EGFR, TP53
6brain stem cancer10.4EGFR, TP53
7lip cancer10.4EGFR, TP53
8calloso-genital dysplasia10.4KRT8, TP53
9soft tissue sarcoma childhood10.4EGFR, TP53
10vulvar benign neoplasm10.4EGFR, TP53
11primary syphilis10.4EGFR, KRT8
12esophageal adenoid cystic carcinoma10.4EGFR, KIT
13peritoneal cystic mesothelioma10.4EGFR, TP53
14eccrine papillary adenocarcinoma10.4EGFR, KIT
15external ear squamous cell carcinoma10.3KIT, TP53
16pancytopenia10.3EGFR, TP53
17ovarian mesodermal adenosarcoma10.3KIT, TP53
18immune system cancer10.3KRT8, TP53
19osteoblastoma10.3KRT8, TP53
20exposure keratitis10.3KIT, TP53
21mucocele of salivary gland10.3KIT, TP53
22melas syndrome10.3EGFR, TP53
23pulmonary subvalvular stenosis10.3EGFR, TP53
24adult astrocytic tumour10.3EGFR, TP53
25head and neck carcinoma10.3KIT, TP53
26homocystinuria10.3EGFR, TP53
27sebaceous breast carcinoma10.3KIT, TP53
28pulmonary immaturity10.3TP53, VIM
29sensory system cancer10.3KIT, TP53
30integumentary system benign neoplasm10.3EGFR, TP53
31juvenile astrocytoma10.3EGFR, TP53
32cervical large cell neuroendocrine carcinoma10.3EGFR, KIT
33spondylitis10.3EGFR, KRT14
34distal monosomy 9p10.3EGFR, VIM
35liver rhabdomyosarcoma10.3KIT, TP53
36malignant teratocarcinosarcoma10.2KIT, VIM
37nasal cavity squamous cell carcinoma10.2EGFR, KRT14
38cleft lip and palate malrotation cardiopathy10.2EGFR, TP53
39breast papillomatosis10.2KIT, VIM
40brain stem ependymoma10.2TP53, VIM
41benign mesothelioma10.2KIT, VIM
42epidermal nevus vitamin d resistant rickets10.2EGFR, VIM
43mixed liposarcoma10.2KIT, VIM
44nerve root neoplasm10.2KIT, VIM
45breast adenomyoepithelial adenosis10.2TP53, VIM
46skin pilomatrix carcinoma10.2KRT14, KRT8
47lymphoepithelioma-like carcinoma10.2EGFR, KRT14
48epidermolysis bullosa acquisita10.2KIT, VIM
49ovarian clear cell adenocarcinoma10.2KRT14, KRT8
50lymphoplasmacyte-rich meningioma10.2KRT8, VIM

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to pleomorphic carcinoma

Symptoms for Pleomorphic Carcinoma

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Drugs & Therapeutics for Pleomorphic Carcinoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial of Radiotherapy and Panitumumab in Salivary Gland MalignanciesWithdrawnNCT00984217Phase 2

Search NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

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Anatomical Context for Pleomorphic Carcinoma

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MalaCards organs/tissues related to Pleomorphic Carcinoma:

33
Salivary gland, Liver, Lung, Monocytes, Prostate, Breast, Neutrophil

Animal Models for Pleomorphic Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

38 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0EGFR, KRT14, TP53, ZEB1
2MP:00053718.4EGFR, KIT, PDGFRA, TP53, ZEB1
3MP:00053778.4EGFR, KIT, KRT14, TP53, ZEB1
4MP:00053918.1EGFR, KIT, KRT14, TP53, VIM, ZEB1
5MP:00053797.8EGFR, KIT, KRT14, PDGFRA, TP53, ZEB1
6MP:00020067.8EGFR, KIT, KRT14, PDGFRA, TP53, ZEB1
7MP:00011867.8EGFR, KIT, KRT14, PDGFRA, TP53, ZEB1
8MP:00107717.8EGFR, KIT, KRT14, PDGFRA, TP53, ZEB1
9MP:00053697.8EGFR, KIT, PDGFRA, TP53, VIM, ZEB1
10MP:00053827.7EGFR, KIT, KRT14, PDGFRA, TP53, ZEB1
11MP:00053807.6EGFR, KIT, KRT8, PDGFRA, TP53, VIM
12MP:00053817.3EGFR, KIT, KRT14, KRT8, PDGFRA, TP53
13MP:00053857.3EGFR, KIT, KRT8, PDGFRA, TP53, VIM
14MP:00053887.3EGFR, KIT, KRT14, PDGFRA, TP53, VIM
15MP:00053896.9EGFR, KIT, KRT14, KRT8, PDGFRA, TP53
16MP:00053766.8EGFR, KIT, KRT14, KRT8, PDGFRA, TP53
17MP:00107686.7EGFR, KIT, KRT14, KRT8, PDGFRA, TP53
18MP:00053786.7EGFR, KIT, KRT14, KRT8, PDGFRA, TP53
19MP:00053876.6EGFR, KIT, KRT14, KRT8, PDGFRA, TP53
20MP:00053976.6EGFR, KIT, KRT14, KRT8, PDGFRA, TP53

Publications for Pleomorphic Carcinoma

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Articles related to Pleomorphic Carcinoma:

(show top 50)    (show all 106)
idTitleAuthorsYear
1
Plasma MASP-1 concentration and its relationship to recovery from coronary artery lesion in children with Kawasaki disease. (26536449)
2015
2
NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis. (24202705)
2014
3
Parkinson's Disease Gene Therapy: Success by Design Meets Failure by Efficacy. (24356252)
2013
4
Mannose binding lectin and mannose binding lectin-associated serine protease-2 genes polymorphisms in human T-lymphotropic virus infection. (23861212)
2013
5
Riociguat for pulmonary hypertension. (24304057)
2013
6
Gestational age at birth and risk of testicular cancer. (22314417)
2012
7
Primary myelofibrosis and the "bad seeds in bad soil" concept. (23259918)
2012
8
Adult polyglucosan body disease: a rare presentation with chronic liver disease and ground-glass hepatocellular inclusions. (21538287)
2011
9
Management of delayed complications after repair of esophageal atresia with creation of a neoesophagus. (21337900)
2011
10
Structural evidence of substrate specificity in mammalian peroxidases: structure of the thiocyanate complex with lactoperoxidase and its interactions at 2.4 A resolution. (19339248)
2009
11
The role of imaging in polymyalgia rheumatica/giant cell arteritis. (18594807)
2008
12
Clinical observation on 30 cases of transient cerebral ischemia attack treated with acupuncture and medication. (17710801)
2007
13
Searching for IgA nephropathy candidate genes: genetic studies combined with high throughput innovative investigations. (17495441)
2007
14
Polymerization of fibrin: Direct observation and quantification of individual B:b knob-hole interactions. (16940416)
2007
15
Therapeutic effect of acupuncture on allergic rhinitis and its effects on immunologic function]. (16941973)
2006
16
Polymorphisms in the xylosyltransferase genes cause higher serum XT-I activity in patients with pseudoxanthoma elasticum (PXE) and are involved in a severe disease course. (16571645)
2006
17
Increased cerebrospinal fluid and serum levels of S100B in first-onset schizophrenia are not related to a degenerative release of glial fibrillar acidic protein, myelin basic protein and neurone-specific enolase from glia or neurones. (17043297)
2006
18
Creatine deficiency syndromes]. (15800449)
2005
19
Characterization of the 3' untranslated region of the human mu-opioid receptor (MOR-1) mRNA. (16122888)
2005
20
Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine. (16408020)
2005
21
Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes. (15774856)
2005
22
The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells. (14760089)
2004
23
Enhanced activation of and increased production of matrix metalloproteinase-9 by human blood monocytes upon adhering to carbamylated collagen. (15063715)
2004
24
Fasting acylation-stimulating protein is predictive of postprandial triglyceride clearance. (14563826)
2004
25
The serotonin 2A -1438 G/A receptor polymorphism in a group of Swedish male criminals. (12875919)
2003
26
Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenal. (12925534)
2003
27
Gut perforation in MALT lymphoma of colon. (11940502)
2002
28
Fascin is involved in the antigen presentation activity of mature dendritic cells. (11123310)
2001
29
Keratocyte loss in Acanthamoeba keratitis: phagocytosis, necrosis or apoptosis? (11340887)
2000
30
Congenital lymphocytic choriomeningitis virus infection: an underdiagnosed disease. (10440448)
1999
31
Recent progress in clinical aspects of receptor research]. (9702034)
1998
32
Comparison of the effects of theophylline and caffeine on serum erythropoietin concentration in premature infants. (9625339)
1998
33
The gamma subunit of rod cGMP-phosphodiesterase blocks the enzyme catalytic site. (9115217)
1997
34
Altered transfer of cholesteryl esters and phospholipids in plasma from alcohol abusers. (9409280)
1997
35
An autocrine/paracrine role of human decidual relaxin. I. Interstitial collagenase (matrix metalloproteinase-1) and tissue plasminogen activator. (9096859)
1997
36
Cellular mechanisms underlying adenosine actions on cholinergic transmission in enteric neurons. (8760055)
1996
37
Tropical spastic paraparesis and HTLV-I infection: clinical and epidemiological study in Lima, Peru. (8981307)
1996
38
D2 receptor blockade by flunarizine and cinnarizine explains extrapyramidal side effects. A SPECT study. (7714010)
1995
39
Varicella (purpura fulminans variant) in an adult diagnosed at autopsy. (7546024)
1995
40
Altered expression of ALDP in X-linked adrenoleukodystrophy. (7668254)
1995
41
A ribozyme which discriminates in vitro between PML/RAR alpha, the t(15;17)-associated fusion RNA of acute promyelocytic leukemia, and PML and RAR alpha, the transcripts from the nonrearranged alleles. (7987829)
1994
42
Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. (7961680)
1994
43
Right ventricular diastolic function in chronic obstructive lung disease. (1563502)
1992
44
Systemic lymphoblastoid interferon therapy in chronic progressive multiple sclerosis. I. Clinical and MRI evaluation. (2179764)
1990
45
Progeria. (2286450)
1990
46
Collagenous colitis. (3758824)
1986
47
Sequence of the cDNA and gene for angiogenin, a human angiogenesis factor. (2866795)
1985
48
Color plates to help identify patients with blue cone monochromatism. (6602551)
1983
49
The Eaton-Lambert syndrome in ocular myasthenia gravis. (4855164)
1974
50
The Pelger-HuA13618374)
1959

Variations for Pleomorphic Carcinoma

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Expression for genes affiliated with Pleomorphic Carcinoma

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Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for genes affiliated with Pleomorphic Carcinoma

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Pathways related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathwaysScoreTop Affiliating Genes
19.8EGFR, TP53
29.8EGFR, TP53
39.7KRT8, TP53
49.3EGFR, PDGFRA
59.3EGFR, PDGFRA
6
Show member pathways
9.3EGFR, KIT, TP53
79.2EGFR, TP53, VIM
89.1TP53, VIM, ZEB1
98.9EGFR, PDGFRA, TP53
10
Show member pathways
8.9EGFR, PDGFRA, TP53
11
Show member pathways
8.9EGFR, PDGFRA, TP53
128.9EGFR, PDGFRA, TP53
13
Show member pathways
8.9KRT14, KRT8, VIM
148.9EGFR, KIT, PDGFRA
15
Show member pathways
8.9EGFR, KIT, PDGFRA
16
Show member pathways
8.5EGFR, KIT, PDGFRA, TP53
178.5EGFR, KIT, PDGFRA, TP53
188.5EGFR, KIT, PDGFRA, TP53
198.5EGFR, KIT, PDGFRA, TP53
207.9EGFR, PDGFRA, TP53, VIM, ZEB1

GO Terms for genes affiliated with Pleomorphic Carcinoma

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Cellular components related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.4KRT14, KRT8

Biological processes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAP kinase activityGO:004340610.1EGFR, KIT
2phosphatidylinositol phosphorylationGO:004685410.0EGFR, KIT
3positive regulation of phospholipase C activityGO:00108639.7KIT, PDGFRA
4embryonic skeletal system morphogenesisGO:00487049.6PDGFRA, ZEB1
5positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.5KIT, PDGFRA
6positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.3KIT, PDGFRA
7phosphatidylinositol-mediated signalingGO:00480159.3EGFR, KIT, PDGFRA
8cell chemotaxisGO:00603269.2KIT, PDGFRA
9transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.2EGFR, KIT, PDGFRA
10protein autophosphorylationGO:00467779.1EGFR, KIT, PDGFRA
11insulin receptor signaling pathwayGO:00082868.9EGFR, KIT, PDGFRA
12vascular endothelial growth factor receptor signaling pathwayGO:00480108.6EGFR, KIT, PDGFRA

Molecular functions related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:00316259.9EGFR, TP53
2protein tyrosine kinase activityGO:00047138.9EGFR, KIT, PDGFRA

Sources for Pleomorphic Carcinoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet