MCID: PLM016
MIFTS: 36

Pleomorphic Carcinoma malady

Categories: Cancer diseases

Aliases & Classifications for Pleomorphic Carcinoma

Aliases & Descriptions for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5662
NCIt 47 C4094
SNOMED-CT 64 16741004
UMLS 69 C0334233

Summaries for Pleomorphic Carcinoma

Disease Ontology : 12 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary : Pleomorphic Carcinoma is related to agenesis and aplasia of uterine body and ureter adenocarcinoma. An important gene associated with Pleomorphic Carcinoma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Glioma and Endometrial cancer. Affiliated tissues include lung, pancreas and breast, and related phenotypes are Decreased substrate adherent cell growth and growth/size/body region

Related Diseases for Pleomorphic Carcinoma

Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
id Related Disease Score Top Affiliating Genes
1 agenesis and aplasia of uterine body 10.3 EGFR NKX2-1
2 ureter adenocarcinoma 10.3 EGFR NKX2-1
3 wolffian adnexal neoplasm 10.2 EGFR TP53
4 paternal uniparental disomy of chromosome 1 10.2 EGFR TP53
5 brainstem intraparenchymal clear cell meningioma 10.2 EGFR TP53
6 acrodermatitis chronica atrophicans 10.2 ALK TP53
7 tmem70 defect 10.2 NKX2-1 TP53
8 triple-receptor negative breast cancer 10.2 EGFR PGR
9 skin sarcoma 10.2 EGFR PGR
10 cervical lymphoepithelioma-like carcinoma 10.2 EGFR PGR
11 childhood embryonal testis carcinoma 10.2 EGFR TP53
12 kidney disease 10.2 NKX2-1 TP53
13 nervous system hibernoma 10.2 EGFR PGR
14 fallopian tube papillary adenocarcinoma 10.2 ALK TP53
15 bone deterioration disease 10.2 NKX2-1 TP53
16 spastic paraplegia 1 10.2 EGFR TP53
17 basaloid squamous cell carcinoma 10.2 EGFR PGR
18 chronic monocytic leukemia 10.2 EGFR TP53
19 aortitis 10.2 PGR TP53
20 pericardium leiomyoma 10.2 PGR TP53
21 combined t cell and b cell immunodeficiency 10.2 EGFR PGR
22 camptomelic syndrome long limb type 10.2 KRT8 TP53
23 anomalous left coronary artery from the pulmonary artery 10.2 EGFR PGR
24 breast ductal carcinoma 10.2 PGR TP53
25 duodenal obstruction 10.2 KRT8 NKX2-1
26 acinar cell carcinoma 10.2 PGR TP53
27 lacrimal gland squamous cell carcinoma 10.2 KRT8 TP53
28 classic congenital mesoblastic nephroma 10.2 PGR TP53
29 secondary hyperparathyroidism of renal origin 10.2 EGFR TP53
30 mental retardation, autosomal recessive 49 10.2 KRT8 TP53
31 bone marrow cancer 10.2 NKX2-1 PGR
32 villoglandular endometrial endometrioid adenocarcinoma 10.2 PGR TP53
33 vaginal adenosarcoma 10.2 PGR TP53
34 paraphimosis 10.1 PGR TP53
35 seminoma 10.1 PGR TP53
36 occipital encephalocele 10.1 KRT18 KRT8
37 woolly hair, autosomal dominant 10.1 KRT18 KRT8
38 proteus-like syndrome 10.1 KRT18 KRT8
39 exudative glomerulonephritis 10.1 EGFR NKX2-1 TP53
40 male reproductive organ benign neoplasm 10.1 PGR TP53
41 ganglioneuroblastoma 10.1 EGFR KRT8
42 brachial plexus neuropathy 10.1 EGFR NKX2-1 TP53
43 central nervous system primitive neuroectodermal neoplasm 10.1 PGR TP53
44 bartholin's gland adenoid cystic carcinoma 10.1 KRT18 KRT8
45 pulmonary fibrosis and/or bone marrow failure, telomere-related, 1 10.1 EGFR NKX2-1 TP53
46 multicentric papillary thyroid carcinoma 10.1 EGFR TP53
47 pancreatic cystadenoma 10.1 ALK EGFR TP53
48 pancreatic cancer 10.1 KRT8 TP53
49 gastrointestinal system cancer 10.1 NKX2-1 PGR
50 sclerosing hemangioma 10.1 EGFR PGR

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to Pleomorphic Carcinoma

Symptoms & Phenotypes for Pleomorphic Carcinoma

GenomeRNAi Phenotypes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.35 KIT
2 Decreased substrate adherent cell growth GR00193-A-2 9.35 KIT ALK EGFR
3 Decreased substrate adherent cell growth GR00193-A-4 9.35 KIT
4 Increased cell death HMECs cells GR00103-A-0 8.92 EGFR KRT18 PGR TP53

MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.04 ALK EGFR KIT KRT18 KRT8 NKX2-1
2 cardiovascular system MP:0005385 10.02 EGFR KIT KRT8 NKX2-1 PGR TP53
3 homeostasis/metabolism MP:0005376 10.02 ALK EGFR KIT KRT8 NKX2-1 PGR
4 mortality/aging MP:0010768 10.01 ALK EGFR KIT KRT18 KRT8 NKX2-1
5 embryo MP:0005380 10 EGFR KIT KRT18 KRT8 PGR TP53
6 endocrine/exocrine gland MP:0005379 9.99 ALK EGFR KIT NKX2-1 PGR TP53
7 digestive/alimentary MP:0005381 9.93 EGFR KIT KRT8 NKX2-1 TP53
8 integument MP:0010771 9.85 TP53 ALK EGFR KIT PGR
9 neoplasm MP:0002006 9.85 KIT NKX2-1 PGR TP53 ALK EGFR
10 liver/biliary system MP:0005370 9.83 EGFR KIT KRT18 KRT8 TP53
11 no phenotypic analysis MP:0003012 9.72 EGFR TP53 KIT NKX2-1 PGR
12 reproductive system MP:0005389 9.7 ALK EGFR KIT KRT8 NKX2-1 PGR
13 pigmentation MP:0001186 9.56 ALK EGFR KIT TP53
14 respiratory system MP:0005388 9.35 ALK EGFR KIT NKX2-1 TP53
15 skeleton MP:0005390 9.1 ALK EGFR KIT NKX2-1 PGR TP53

Drugs & Therapeutics for Pleomorphic Carcinoma

Interventional clinical trials:


id Name Status NCT ID Phase
1 Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies Withdrawn NCT00984217 Phase 2

Search NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

Anatomical Context for Pleomorphic Carcinoma

MalaCards organs/tissues related to Pleomorphic Carcinoma:

39
Lung, Pancreas, Breast, Colon, Thyroid, Brain, Tongue

Publications for Pleomorphic Carcinoma

Articles related to Pleomorphic Carcinoma:

(show top 50) (show all 116)
id Title Authors Year
1
"Pseudoprogression" of Pulmonary Pleomorphic Carcinoma during Nivolumab Therapy. ( 27189927 )
2016
2
Pleomorphic Carcinoma of the Colon: Morphological and Immunohistochemical Findings. ( 27462191 )
2016
3
High co-expression of PD-L1 and HIF-1I+ correlates with tumour necrosis in pulmonary pleomorphic carcinoma. ( 27107327 )
2016
4
Pemetrexed and bevacizumab-containing chemotherapy for pleomorphic carcinoma of the lung. ( 27073676 )
2016
5
Pleomorphic Carcinoma of the Lung: Relationship Between CT Findings and Prognosis. ( 27144416 )
2016
6
P1.27: A Clinicopathological Study of ResectedA Pulmonary Pleomorphic Carcinoma: Track: Advanced NSCLC. ( 27676513 )
2016
7
A rare primary pulmonary tumor with difficult diagnosis: pleomorphic carcinoma. ( 27525610 )
2016
8
Anaplastic Lymphoma Kinase (ALK) Rearrangement-positive Lung Cancer with Transformation to Pleomorphic Carcinoma. ( 26568007 )
2015
9
Successful treatment of two consecutive cases of pulmonary pleomorphic carcinoma with platinum chemotherapy. ( 26722286 )
2015
10
Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas. ( 26329973 )
2015
11
Retrospective analysis of the efficacy of chemotherapy and molecular targeted therapy for advanced pulmonary pleomorphic carcinoma. ( 26682906 )
2015
12
Clinicoradiological outcomes of 33 cases of surgically resected pulmonary pleomorphic carcinoma: correlation with prognostic indicators. ( 25994197 )
2015
13
Tumor-related gene expression levels in pulmonary pleomorphic carcinoma. ( 26031756 )
2015
14
A Rare Case of Pleomorphic Carcinoma of the Lung Harboring an Anaplastic Lymphoma Kinase (ALK) Rearrangement. ( 26521903 )
2015
15
Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung. ( 26345631 )
2015
16
Promising effect of chemotherapy with bevacizumab for patients with pulmonary pleomorphic carcinoma: Two case reports and a literature review. ( 26521107 )
2015
17
Response to Crizotinib and Clinical Outcome in ALK-Rearranged Pulmonary Pleomorphic Carcinoma. ( 25898961 )
2015
18
Clinicopathological analysis of pleomorphic carcinoma of the lung: diffuse ZEB1 expression predicts poor survival. ( 25479687 )
2015
19
EGFR and KRAS mutations in pulmonary pleomorphic carcinoma and their correlation with clinicopathologic features. ( 26199566 )
2015
20
Comparative analysis of tumor angiogenesis and clinical features of 55 cases of pleomorphic carcinoma and adenocarcinoma of the lung. ( 25550577 )
2015
21
Bevacizumab for critical brain metastases in a patient with pulmonary pleomorphic carcinoma. ( 25130117 )
2014
22
A case of synchronous double primary lung cancer presenting with pleomorphic carcinoma and adenocarcinoma. ( 25553415 )
2014
23
Unexpectedly long intravenous and intracardiac extension of a small-sized pulmonary pleomorphic carcinoma. ( 25590004 )
2014
24
Pulmonary Pleomorphic Carcinoma Metastasis to the Midfoot. ( 24840733 )
2014
25
Sarcomatous Components May Predict Prognosis in Patients with Pulmonary Pleomorphic Carcinoma. ( 25423314 )
2014
26
A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity. ( 25123545 )
2014
27
Pleomorphic Carcinoma Showing Rapid Growth, Multiple Metastases, and Intestinal Perforation. ( 24492166 )
2014
28
Pulmonary pleomorphic carcinoma detected as a result of pneumothorax and the subsequent occurrence of multiple cystic metastases. ( 25214846 )
2014
29
Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung. ( 24846683 )
2014
30
Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine. ( 25400187 )
2014
31
Long-term survival in a case of pleomorphic carcinoma with a brain metastasis. ( 25566055 )
2014
32
Pleomorphic carcinoma of breast: a case report and review of literature. ( 25197400 )
2014
33
Recurrent intussusception caused by intestinal metastasis of pulmonary pleomorphic carcinoma. ( 24924845 )
2014
34
Pulmonary pleomorphic carcinoma with multiple metastases to the right posterior knee complicated by paraneoplastic hypercalcemia. ( 24396467 )
2014
35
Spindle Cell Component in Pleomorphic Carcinoma Showing Polypoid Growth in the Pulmonary Vein. ( 23903706 )
2013
36
Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC. ( 23651662 )
2013
37
Pulmonary pleomorphic carcinoma with rapid progression. ( 24532631 )
2013
38
Long-term remission achieved via combined chemotherapy and radiotherapy in a non-resectable granulocyte colony-stimulating factor producing pleomorphic carcinoma of the lung. ( 24088763 )
2013
39
Intussusception Caused by Intestinal Metastasis from Lung Pleomorphic Carcinoma. ( 23903709 )
2013
40
Multiple Cytokines-Producing Pleomorphic Carcinoma of Lung with Metastasis to the Small Intestine. ( 24200664 )
2013
41
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. ( 23696935 )
2013
42
Clinicopathological characteristics of surgically resected pulmonary pleomorphic carcinoma. ( 22228848 )
2012
43
Pleomorphic carcinoma of the breast with expression of macrophage markers: report of two cases. ( 22726069 )
2012
44
Pulmonary pleomorphic carcinoma producing granulocyte-macrophage colony-stimulating factor: report of a case. ( 22068679 )
2012
45
A case of pleomorphic carcinoma of the lung suspected from infectious bulla. ( 23087315 )
2012
46
Tumor angiogenesis in 75 cases of pleomorphic carcinoma of the lung. ( 22843911 )
2012
47
Resected pleomorphic carcinoma of the gallbladder. ( 23341796 )
2012
48
Two consecutive cases of platinum-refractory pulmonary pleomorphic carcinoma that showed dramatic responses to MAID (mesna, doxorubicin, ifosfamide and dacarbazine) chemotherapy. ( 20926411 )
2011
49
Radical resection of a pleomorphic carcinoma after relieving airway obstruction by the endobronchial snare method. ( 21484559 )
2011
50
Pleomorphic carcinoma of the lung arising in a patient with Li-Fraumeni syndrome: report of a case. ( 21626334 )
2011

Variations for Pleomorphic Carcinoma

Expression for Pleomorphic Carcinoma

Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for Pleomorphic Carcinoma

GO Terms for Pleomorphic Carcinoma

Biological processes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.58 ALK EGFR KIT
2 protein autophosphorylation GO:0046777 9.54 ALK EGFR KIT
3 peptidyl-tyrosine phosphorylation GO:0018108 9.5 ALK EGFR KIT
4 extrinsic apoptotic signaling pathway GO:0097191 9.43 KRT18 KRT8
5 hepatocyte apoptotic process GO:0097284 9.26 KRT18 KRT8
6 cerebral cortex cell migration GO:0021795 9.16 EGFR NKX2-1
7 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.13 ALK EGFR KIT
8 phosphatidylinositol-mediated signaling GO:0048015 8.8 EGFR KIT TP53

Molecular functions related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.43 ALK EGFR KIT
2 enzyme binding GO:0019899 9.26 EGFR NKX2-1 PGR TP53
3 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.16 EGFR KIT
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 ALK EGFR KIT

Sources for Pleomorphic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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