MCID: PLM016
MIFTS: 36

Pleomorphic Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Pleomorphic Carcinoma

MalaCards integrated aliases for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5662
NCIt 47 C4094
SNOMED-CT 64 16741004
UMLS 69 C0334233

Summaries for Pleomorphic Carcinoma

Disease Ontology : 12 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary : Pleomorphic Carcinoma is related to intestinal perforation and lung cancer. An important gene associated with Pleomorphic Carcinoma is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are Endometrial cancer and Tyrosine Kinases / Adaptors. Affiliated tissues include lung, pancreas and salivary gland, and related phenotypes are Decreased substrate adherent cell growth and growth/size/body region

Related Diseases for Pleomorphic Carcinoma

Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
id Related Disease Score Top Affiliating Genes
1 intestinal perforation 30.2 PGR TP53
2 lung cancer 27.1 ALK EGFR KIT KRT18 NKX2-1 TP53
3 tubular adenocarcinoma 10.6 EGFR NKX2-1
4 pediatric infratentorial ependymoma 10.6 EGFR TP53
5 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.6 EGFR TP53
6 childhood infratentorial neoplasm 10.6 EGFR TP53
7 glucocorticoid-induced osteoporosis 10.5 ALK TP53
8 pleural empyema 10.5 NKX2-1 TP53
9 gorham's disease 10.5 ALK EGFR
10 skin sarcoma 10.5 EGFR PGR
11 her2-receptor negative breast cancer 10.5 EGFR PGR
12 subglottis verrucous carcinoma 10.5 EGFR PGR
13 lymphopenia 10.5 EGFR TP53
14 eccrine papillary adenocarcinoma 10.5 ALK TP53
15 gastric tubular adenocarcinoma 10.5 EGFR PGR
16 multiple carboxylase deficiency 10.5 EGFR TP53
17 sparse hair ptosis mental retardation 10.5 EGFR TP53
18 penis squamous cell carcinoma 10.5 EGFR PGR
19 large cell neuroendocrine carcinoma 10.5 ALK EGFR
20 brenner tumor of the vagina 10.5 ALK TP53
21 spinal cord dermoid cyst 10.5 EGFR TP53
22 brenner tumor of ovary 10.5 ALK TP53
23 dmd-related dilated cardiomyopathy 10.5 EGFR PGR
24 bone development disease 10.5 NKX2-1 TP53
25 secondary hyperparathyroidism of renal origin 10.5 EGFR TP53
26 molluscum contagiosum 10.5 EGFR TP53
27 malignant thyroid stimulating hormone producing neoplasm of pituitary gland 10.4 EGFR PGR
28 superior mesenteric artery syndrome 10.4 KRT8 NKX2-1
29 comedo carcinoma 10.4 EGFR PGR
30 blastema predominant kidney wilms' tumor 10.4 PGR TP53
31 central nervous system organ benign neoplasm 10.4 PGR TP53
32 lung adenoma 10.4 PGR TP53
33 camptocormism 10.4 KRT8 TP53
34 differentiating neuroblastoma 10.4 EGFR KRT8
35 cervical benign neoplasm 10.4 EGFR TP53
36 breast myoepithelial neoplasm 10.4 PGR TP53
37 leiomyoma cutis 10.4 PGR TP53
38 prostatic acinar adenocarcinoma 10.4 PGR TP53
39 intraductal breast myoepitheliosis 10.4 PGR TP53
40 esophagus sarcoma 10.4 EGFR PGR
41 ovarian mesodermal adenosarcoma 10.4 PGR TP53
42 chest wall lymphoma 10.4 PGR TP53
43 retinal detachment 10.4 PGR TP53
44 trichoepithelioma, multiple familial, 1 10.4 KRT8 TP53
45 myxedema 10.4 EGFR TP53
46 central nervous system germ cell tumor 10.4 PGR TP53
47 ureter adenocarcinoma 10.4 EGFR PGR
48 otitis externa 10.4 PGR TP53
49 kidney benign neoplasm 10.4 NKX2-1 PGR
50 organ system benign neoplasm 10.4 PGR TP53

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to Pleomorphic Carcinoma

Symptoms & Phenotypes for Pleomorphic Carcinoma

GenomeRNAi Phenotypes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.35 KIT
2 Decreased substrate adherent cell growth GR00193-A-2 9.35 ALK EGFR KIT
3 Decreased substrate adherent cell growth GR00193-A-4 9.35 KIT
4 Increased cell death HMECs cells GR00103-A-0 8.92 EGFR KRT18 PGR TP53

MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.04 ALK EGFR KIT KRT18 KRT8 NKX2-1
2 cardiovascular system MP:0005385 10.02 EGFR KIT KRT8 NKX2-1 PGR TP53
3 mortality/aging MP:0010768 10.01 ALK EGFR KIT KRT18 KRT8 NKX2-1
4 embryo MP:0005380 10 KRT18 KRT8 PGR TP53 EGFR KIT
5 homeostasis/metabolism MP:0005376 10 NKX2-1 PGR TP53 ALK EGFR KIT
6 endocrine/exocrine gland MP:0005379 9.99 ALK EGFR KIT NKX2-1 PGR TP53
7 digestive/alimentary MP:0005381 9.93 EGFR KIT KRT8 NKX2-1 TP53
8 neoplasm MP:0002006 9.85 ALK EGFR KIT NKX2-1 PGR TP53
9 liver/biliary system MP:0005370 9.83 EGFR KIT KRT18 KRT8 TP53
10 no phenotypic analysis MP:0003012 9.72 TP53 EGFR KIT NKX2-1 PGR
11 reproductive system MP:0005389 9.7 ALK EGFR KIT KRT8 NKX2-1 PGR
12 hearing/vestibular/ear MP:0005377 9.65 EGFR KIT TP53
13 pigmentation MP:0001186 9.56 ALK EGFR KIT TP53
14 respiratory system MP:0005388 9.35 ALK EGFR KIT NKX2-1 TP53
15 skeleton MP:0005390 9.1 ALK EGFR KIT NKX2-1 PGR TP53

Drugs & Therapeutics for Pleomorphic Carcinoma

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies Withdrawn NCT00984217 Phase 2 Panitumumab

Search NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

Anatomical Context for Pleomorphic Carcinoma

MalaCards organs/tissues related to Pleomorphic Carcinoma:

39
Lung, Pancreas, Salivary Gland, Thyroid, Colon, Brain, Tongue

Publications for Pleomorphic Carcinoma

Articles related to Pleomorphic Carcinoma:

(show top 50) (show all 124)
id Title Authors Year
1
Marked response to pembrolizumab in a patient with pulmonary pleomorphic carcinoma highly positive for PD-L1. ( 28754417 )
2017
2
Atrial Involvement in Pleomorphic Carcinoma of the Lung. ( 28883256 )
2017
3
Diffuse fluorodeoxyglucose-positron uptake in the bone marrow of a patient with granulocyte colony-stimulating factor-producing pleomorphic carcinoma of the lung: A case report. ( 28685085 )
2017
4
Breast metastasis of pulmonary pleomorphic carcinoma: a case report. ( 28188513 )
2017
5
The Successful Treatment of Pulmonary Pleomorphic Carcinoma with Pembrolizumab: A Case Report. ( 28878661 )
2017
6
Stage IV pleomorphic carcinoma of the lung without recurrence for 6A years: a case report. ( 28224563 )
2017
7
Pulmonary pleomorphic carcinoma: A case report and review of the literature. ( 28723756 )
2017
8
Clinicopathological factors influenced the prognosis of surgically resected pulmonary pleomorphic carcinoma. ( 28616281 )
2017
9
P1.27: A Clinicopathological Study of ResectedA Pulmonary Pleomorphic Carcinoma: Track: Advanced NSCLC. ( 27676513 )
2016
10
Pleomorphic Carcinoma of the Colon: Morphological and Immunohistochemical Findings. ( 27462191 )
2016
11
Pemetrexed and bevacizumab-containing chemotherapy for pleomorphic carcinoma of the lung. ( 27073676 )
2016
12
A rare primary pulmonary tumor with difficult diagnosis: pleomorphic carcinoma. ( 27525610 )
2016
13
High co-expression of PD-L1 and HIF-1I+ correlates with tumour necrosis in pulmonary pleomorphic carcinoma. ( 27107327 )
2016
14
Pleomorphic Carcinoma of the Lung: Relationship Between CT Findings and Prognosis. ( 27144416 )
2016
15
"Pseudoprogression" of Pulmonary Pleomorphic Carcinoma during Nivolumab Therapy. ( 27189927 )
2016
16
Response to Crizotinib and Clinical Outcome in ALK-Rearranged Pulmonary Pleomorphic Carcinoma. ( 25898961 )
2015
17
Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas. ( 26329973 )
2015
18
Comparative analysis of tumor angiogenesis and clinical features of 55 cases of pleomorphic carcinoma and adenocarcinoma of the lung. ( 25550577 )
2015
19
Successful treatment of two consecutive cases of pulmonary pleomorphic carcinoma with platinum chemotherapy. ( 26722286 )
2015
20
Clinicoradiological outcomes of 33 cases of surgically resected pulmonary pleomorphic carcinoma: correlation with prognostic indicators. ( 25994197 )
2015
21
Tumor-related gene expression levels in pulmonary pleomorphic carcinoma. ( 26031756 )
2015
22
EGFR and KRAS mutations in pulmonary pleomorphic carcinoma and their correlation with clinicopathologic features. ( 26199566 )
2015
23
Anaplastic Lymphoma Kinase (ALK) Rearrangement-positive Lung Cancer with Transformation to Pleomorphic Carcinoma. ( 26568007 )
2015
24
Retrospective analysis of the efficacy of chemotherapy and molecular targeted therapy for advanced pulmonary pleomorphic carcinoma. ( 26682906 )
2015
25
Clinicopathological analysis of pleomorphic carcinoma of the lung: diffuse ZEB1 expression predicts poor survival. ( 25479687 )
2015
26
A Rare Case of Pleomorphic Carcinoma of the Lung Harboring an Anaplastic Lymphoma Kinase (ALK) Rearrangement. ( 26521903 )
2015
27
Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung. ( 26345631 )
2015
28
Promising effect of chemotherapy with bevacizumab for patients with pulmonary pleomorphic carcinoma: Two case reports and a literature review. ( 26521107 )
2015
29
Pulmonary Pleomorphic Carcinoma Metastasis to the Midfoot. ( 24840733 )
2014
30
Sarcomatous Components May Predict Prognosis in Patients with Pulmonary Pleomorphic Carcinoma. ( 25423314 )
2014
31
A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity. ( 25123545 )
2014
32
A case of synchronous double primary lung cancer presenting with pleomorphic carcinoma and adenocarcinoma. ( 25553415 )
2014
33
Pulmonary pleomorphic carcinoma with multiple metastases to the right posterior knee complicated by paraneoplastic hypercalcemia. ( 24396467 )
2014
34
Bevacizumab for critical brain metastases in a patient with pulmonary pleomorphic carcinoma. ( 25130117 )
2014
35
Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung. ( 24846683 )
2014
36
Pleomorphic carcinoma of breast: a case report and review of literature. ( 25197400 )
2014
37
Recurrent intussusception caused by intestinal metastasis of pulmonary pleomorphic carcinoma. ( 24924845 )
2014
38
Pleomorphic Carcinoma Showing Rapid Growth, Multiple Metastases, and Intestinal Perforation. ( 24492166 )
2014
39
Unexpectedly long intravenous and intracardiac extension of a small-sized pulmonary pleomorphic carcinoma. ( 25590004 )
2014
40
Long-term survival in a case of pleomorphic carcinoma with a brain metastasis. ( 25566055 )
2014
41
Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine. ( 25400187 )
2014
42
Pulmonary pleomorphic carcinoma detected as a result of pneumothorax and the subsequent occurrence of multiple cystic metastases. ( 25214846 )
2014
43
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. ( 23696935 )
2013
44
Intussusception Caused by Intestinal Metastasis from Lung Pleomorphic Carcinoma. ( 23903709 )
2013
45
Pulmonary pleomorphic carcinoma with rapid progression. ( 24532631 )
2013
46
Spindle Cell Component in Pleomorphic Carcinoma Showing Polypoid Growth in the Pulmonary Vein. ( 23903706 )
2013
47
Long-term remission achieved via combined chemotherapy and radiotherapy in a non-resectable granulocyte colony-stimulating factor producing pleomorphic carcinoma of the lung. ( 24088763 )
2013
48
Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC. ( 23651662 )
2013
49
Multiple Cytokines-Producing Pleomorphic Carcinoma of Lung with Metastasis to the Small Intestine. ( 24200664 )
2013
50
Resected pleomorphic carcinoma of the gallbladder. ( 23341796 )
2012

Variations for Pleomorphic Carcinoma

Expression for Pleomorphic Carcinoma

Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for Pleomorphic Carcinoma

Pathways related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.71 ALK EGFR KIT PGR TP53
2 11.48 ALK EGFR KIT
3 10.87 KRT8 TP53
4 10.78 EGFR TP53
5 10.61 EGFR KIT TP53

GO Terms for Pleomorphic Carcinoma

Biological processes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.61 ALK EGFR KIT
2 protein autophosphorylation GO:0046777 9.58 ALK EGFR KIT
3 peptidyl-tyrosine phosphorylation GO:0018108 9.54 ALK EGFR KIT
4 extrinsic apoptotic signaling pathway GO:0097191 9.46 KRT18 KRT8
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.33 ALK EGFR KIT
6 hepatocyte apoptotic process GO:0097284 9.26 KRT18 KRT8
7 tongue development GO:0043586 9.02 EGFR
8 cerebral cortex cell migration GO:0021795 8.96 EGFR NKX2-1
9 phosphatidylinositol-mediated signaling GO:0048015 8.8 EGFR KIT TP53

Molecular functions related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.43 ALK EGFR KIT
2 enzyme binding GO:0019899 9.26 EGFR NKX2-1 PGR TP53
3 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.16 EGFR KIT
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 ALK EGFR KIT

Sources for Pleomorphic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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