MCID: PLM016
MIFTS: 35

Pleomorphic Carcinoma malady

Cancer diseases category

Aliases & Classifications for Pleomorphic Carcinoma

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Aliases & Descriptions for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 8 61


Classifications:



External Ids:

Disease Ontology8 DOID:5662
SNOMED-CT56 16741004
NCIt39 C4094

Summaries for Pleomorphic Carcinoma

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Disease Ontology:8 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary: Pleomorphic Carcinoma is related to lung cancer and adenocarcinoma. An important gene associated with Pleomorphic Carcinoma is KRT14 (keratin 14), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Cell adhesion Integrin mediated cell adhesion and migration. The compounds b 723 and urea have been mentioned in the context of this disorder. Affiliated tissues include lung, pancreas and breast, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Related Diseases for Pleomorphic Carcinoma

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Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.2KRT18, NKX2-1
2adenocarcinoma29.8KRT14, NKX2-1, KRT18, CAV1
3syringoma10.4KRT14
4intussusception10.3
5angiosarcoma10.2KRT18, KRT14
6intestinal perforation10.2
7thyroiditis10.2
8ameloblastoma10.2KRT18, KRT14
9thymic carcinoma10.2NKX2-1, KRT18
10epidermolysis bullosa simplex10.1KRT14, DES
11neuroendocrine tumor10.1KRT18, NKX2-1
12transitional cell carcinoma10.1KRT18, KRT14
13sarcoma, synovial10.1KRT14, DES
14sex cord-gonadal stromal tumor10.1NKX2-1, DES
15abrikosov's tumor10.1DES, NKX2-1
16mesothelioma, somatic10.1NKX2-1, DES
17wilms tumor10.0NKX2-1, DES
18li-fraumeni syndrome10.0
19spindle cell carcinoma10.0
20gynecomastia10.0
21hypercalcemia10.0
22large cell carcinoma10.0
23small cell carcinoma10.0
24bronchopneumonia10.0
25esophagitis10.0
26mediastinitis10.0
27pneumothorax10.0
28factor v leiden thrombophilia10.0KRT14, NKX2-1
29oral cancer10.0KRT14, CAV1
30cork-handlers' disease10.0KRT18, NKX2-1
31bladder cancer, somatic10.0CAV1, KRT18
32thyroid carcinoma, papillary10.0NKX2-1, CAV1
33squamous cell carcinoma, head and neck10.0KRT18, KRT14
34papillary carcinoma10.0KRT14, KRT18, NKX2-1
35chordoma10.0DES, KRT18, KRT14
36breast cancer10.0KRT14, CAV1
37pleomorphic adenoma10.0KRT18, DES, KRT14
38mesothelioma9.9NKX2-1, KRT14, DES
39noonan syndrome 19.9DES, CAV1
40oxyphilic adenoma9.9CAV1, KRT14, KRT18
41fibrosarcoma9.9DES, CAV1
42psoriasis9.8CAV1, KRT14, KRT18
43retinoblastoma9.8KRT14, KRT18, CAV1
44muscular dystrophy9.8DES, CAV1, KRT14
45lung cancer susceptibility 39.8CAV1, KRT18, NKX2-1
46colorectal cancer9.8CAV1, KRT18, KRT14
47liver cirrhosis9.7KRT18, CAV1
48small cell cancer of the lung, somatic9.6CAV1, NKX2-1, KRT14, KRT18
49kidney cancer9.6KRT14, KRT18, CAV1, NKX2-1
50adenoma9.6NKX2-1, CAV1, KRT14, KRT18

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to pleomorphic carcinoma

Symptoms for Pleomorphic Carcinoma

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Drugs & Therapeutics for Pleomorphic Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Pleomorphic Carcinoma

Search NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

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Anatomical Context for Pleomorphic Carcinoma

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MalaCards organs/tissues related to Pleomorphic Carcinoma:

31
Lung, Pancreas, Breast, Brain, Thyroid, Small intestine, Colon, Tongue

Animal Models for Pleomorphic Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7CAV1, NKX2-1, KRT14
2MP:00053818.7KRT14, NKX2-1, CAV1
3MP:00053888.4KRT14, NKX2-1, CAV1
4MP:00053788.1CAV1, NKX2-1, KRT14, KRT18
5MP:00107687.6KRT18, KRT14, NKX2-1, CAV1, DES

Publications for Pleomorphic Carcinoma

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Articles related to Pleomorphic Carcinoma:

(show top 50)    (show all 99)
idTitleAuthorsYear
1
Comparative analysis of tumor angiogenesis and clinical features of 55 cases of pleomorphic carcinoma and adenocarcinoma of the lung. (25550577)
2015
2
Response to Crizotinib and Clinical Outcome in ALK-Rearranged Pulmonary Pleomorphic Carcinoma. (25898961)
2015
3
Unexpectedly long intravenous and intracardiac extension of a small-sized pulmonary pleomorphic carcinoma. (25590004)
2014
4
Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung. (24846683)
2014
5
A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity. (25123545)
2014
6
Bevacizumab for critical brain metastases in a patient with pulmonary pleomorphic carcinoma. (25130117)
2014
7
Recurrent intussusception caused by intestinal metastasis of pulmonary pleomorphic carcinoma. (24924845)
2014
8
Pulmonary pleomorphic carcinoma with rapid progression. (24532631)
2013
9
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. (23696935)
2013
10
Long-term remission achieved via combined chemotherapy and radiotherapy in a non-resectable granulocyte colony-stimulating factor producing pleomorphic carcinoma of the lung. (24088763)
2013
11
Resected pleomorphic carcinoma of the gallbladder. (23341796)
2012
12
Tumor angiogenesis in 75 cases of pleomorphic carcinoma of the lung. (22843911)
2012
13
Colonic metastases from pleomorphic carcinoma of the lung presenting as an ileocecal intussusception. (21991496)
2011
14
Pleomorphic carcinoma of the lung arising in a patient with Li-Fraumeni syndrome: report of a case. (21626334)
2011
15
Pleomorphic carcinoma of the lung with intrapulmonary aerogenic metastases on FDG PET. (20706051)
2010
16
Clinical characteristics of pleomorphic carcinoma of the lung. (19577320)
2010
17
Pulmonary pleomorphic carcinoma: a clinicopathological study including EGFR mutation analysis. (20107421)
2010
18
Pulmonary pleomorphic carcinoma: diagnosis using small biopsy specimens. (20736811)
2010
19
Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia. (21165299)
2010
20
Genetic heterogeneity of EGFR mutation in pleomorphic carcinoma of the lung: response to gefitinib and clinical outcome. (19155283)
2009
21
The role of palliative chemotherapy for advanced pulmonary pleomorphic carcinoma. (18989796)
2009
22
Esophageal polypoidal mass: presentation of an uncommon pleomorphic carcinoma. (19750865)
2009
23
Pleomorphic carcinoma of the lung with uncommon initial manifestation of intestinal perforation]. (19601528)
2009
24
Pleomorphic carcinoma with osteoclastic giant cells of the breast: immunohistochemical differentiation between coexisting neoplastic and reactive giant cells. (19154262)
2009
25
Pleomorphic carcinoma of the lung in which the sarcomatous element grew rapidly: a case report. (19471225)
2009
26
Two cases of pleomorphic carcinoma with severe systemic inflammation]. (19764522)
2009
27
Pleomorphic carcinoma of the lung: clinicopathologic characteristics of 70 cases. (18769330)
2008
28
Pleomorphic carcinoma of the lung expressing podoplanin and calretinin. (19067851)
2008
29
F-18 FDG PET imaging in a patient with granulocyte colony stimulating factor producing pulmonary pleomorphic carcinoma. (18645378)
2008
30
Long-term survival in two cases of resected gastric metastasis of pulmonary pleomorphic carcinoma. (18594328)
2008
31
Pleomorphic carcinoma of the lung: a report of six cases. (17978928)
2007
32
Expression of caveolin-1 in pleomorphic carcinoma of the lung is correlated with a poor prognosis. (16334154)
2005
33
Pleomorphic carcinoma of the lung associated with loss of heterozygosity of p53 gene. (15888975)
2005
34
Personal experience in surgical management of pulmonary pleomorphic carcinoma. (15511465)
2004
35
Metastatic pleomorphic carcinoma of lung presenting as abdominal pain. (15622698)
2004
36
Pleomorphic carcinoma of lung: comparison of CT features and pathologic findings. (15215543)
2004
37
Resection of a pleomorphic carcinoma of the lung invading the descending aorta. (15173751)
2004
38
Pleomorphic carcinomas of the lung show a selective distribution of gene products involved in cell differentiation, cell cycle control, tumor growth, and tumor cell motility: a clinicopathologic and immunohistochemical study of 31 cases. (12960804)
2003
39
Pleomorphic carcinoma of the breast: clinicopathological analysis of 26 cases of an unusual high-grade phenotype of ductal carcinoma. (10849092)
2000
40
Pathological study of the pleomorphic carcinoma of the lung]. (11866944)
2000
41
A case of pleomorphic carcinoma of the pancreas showing sequential histological change by immunohistochemical study. (7594772)
1995
42
Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells. (8113629)
1993
43
Pleomorphic carcinoma of the gallbladder: report of a case. (1803718)
1991
44
Surgical treatment of pleomorphic carcinoma of the pancreas. (2190511)
1990
45
Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells expressing an epithelial-associated antigen detected by monoclonal antibody 44-3A6. (3254809)
1988
46
Pleomorphic carcinoma of the pancreas: computed-tomographic, sonographic, and pathologic findings. (3880902)
1985
47
Pleomorphic carcinoma of the gallbladder: case report and ultrastructural study. (6539521)
1984
48
Pleomorphic carcinoma of the thyroid. (20312831)
1977
49
A functioning pleomorphic carcinoma of the thyroid. (1277059)
1976
50
Pleomorphic carcinoma of the larynx. (5643249)
1968

Variations for Pleomorphic Carcinoma

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Expression for genes affiliated with Pleomorphic Carcinoma

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Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for genes affiliated with Pleomorphic Carcinoma

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Pathways related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5KRT18, KRT14
2
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility59
Cytoskeleton remodeling Integrin outside in signaling59
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases59
Cell adhesion Tight junctions59
Development MAG dependent inhibition of neurite outgrowth59
9.1NKX2-1, CAV1
39.1KRT18, CAV1
48.5KRT18, CAV1, DES

Compounds for genes affiliated with Pleomorphic Carcinoma

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Compounds related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

(show all 32)
idCompoundScoreTop Affiliating Genes
1b 723449.6DES, NKX2-1
2urea44 24 1111.6KRT18, KRT14
3p002449.4DES, KRT18
4ganglioside449.3CAV1, DES
5mucicarmine449.3DES, KRT14, NKX2-1
6bromodeoxyuridine449.2KRT18, KRT14, DES
7formaldehyde44 2410.1NKX2-1, KRT18, DES
8egcg449.1CAV1, KRT18
9phosphatidylserine44 28 1111.1KRT18, CAV1
10oligonucleotide448.9NKX2-1, CAV1, KRT18
11gold448.9DES, CAV1, KRT18
12dexamethasone44 50 28 1111.8KRT18, NKX2-1, CAV1
13alanine448.8KRT18, KRT14, CAV1
14doxorubicin44 50 1110.8DES, KRT18, CAV1
15fatty acid448.8DES, CAV1, KRT18
16testosterone44 60 24 1111.8CAV1, DES, KRT18
17arginine448.8KRT14, DES, CAV1
18hematoxylin448.8DES, KRT18, KRT14, NKX2-1
19vegf448.7CAV1, DES, KRT18
20nitric oxide44 24 1110.7CAV1, DES, KRT18
21iron44 249.4KRT14, CAV1, KRT18, DES
22oxygen44 249.4DES, CAV1, KRT18
23glucose448.4DES, CAV1, KRT14, KRT18
24steroid448.3CAV1, NKX2-1, DES, KRT18
25cysteine448.3KRT14, DES, CAV1
26paraffin447.9DES, KRT18, KRT14, NKX2-1, CAV1
27progesterone44 28 60 24 1111.9KRT18, DES, CAV1, NKX2-1, KRT14
28threonine447.9NKX2-1, KRT14, KRT18, CAV1, DES
29estrogen447.9DES, KRT18, KRT14, NKX2-1, CAV1
30retinoic acid44 248.9NKX2-1, KRT18, KRT14, DES, CAV1
31serine447.9CAV1, KRT18, KRT14, NKX2-1, DES
32tyrosine447.9CAV1, DES, KRT18, KRT14, NKX2-1

GO Terms for genes affiliated with Pleomorphic Carcinoma

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Cellular components related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.5KRT18, KRT14
2intermediate filamentGO:00058828.6KRT18, KRT14, DES

Molecular functions related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.3KRT14, DES
2structural molecule activityGO:00051989.1KRT18, CAV1
3protein bindingGO:00055157.2KRT18, KRT14, NKX2-1, CAV1, DES

Sources for Pleomorphic Carcinoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet