MCID: PLM016
MIFTS: 40

Pleomorphic Carcinoma malady

Category: Cancer diseases

Aliases & Classifications for Pleomorphic Carcinoma

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Aliases & Descriptions for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:5662
SNOMED-CT59 16741004
NCIt42 C4094
UMLS65 C0334233

Summaries for Pleomorphic Carcinoma

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Disease Ontology:10 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary: Pleomorphic Carcinoma is related to lymphatic system disease and hypogonadotropic hypogonadism-frontoparietal alopecia syndrome. An important gene associated with Pleomorphic Carcinoma is EGFR (Epidermal Growth Factor Receptor), and among its related pathways are Bladder cancer and Gastric cancer network 2. Affiliated tissues include lung, breast and prostate, and related mouse phenotypes are adipose tissue and limbs/digits/tail.

Related Diseases for Pleomorphic Carcinoma

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Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1lymphatic system disease10.6EGFR, TP53
2hypogonadotropic hypogonadism-frontoparietal alopecia syndrome10.6EGFR, TP53
3cervical non-keratinizing squamous cell carcinoma10.6EGFR, TP53
4high molecular weight kininogen deficiency10.6EGFR, TP53
5brain stem cancer10.6EGFR, TP53
6embryoma10.6EGFR, TP53
7lip cancer10.6EGFR, TP53
8calloso-genital dysplasia10.6KRT8, TP53
9soft tissue sarcoma childhood10.6EGFR, TP53
10vulvar benign neoplasm10.6EGFR, TP53
11primary syphilis10.6EGFR, KRT8
12esophageal adenoid cystic carcinoma10.6EGFR, KIT
13peritoneal cystic mesothelioma10.5EGFR, TP53
14eccrine papillary adenocarcinoma10.5EGFR, KIT
15external ear squamous cell carcinoma10.5KIT, TP53
16pancytopenia10.5EGFR, TP53
17ovarian mesodermal adenosarcoma10.5KIT, TP53
18immune system cancer10.5KRT8, TP53
19osteoblastoma10.5KRT8, TP53
20exposure keratitis10.5KIT, TP53
21mucocele of salivary gland10.5KIT, TP53
22melas syndrome10.5EGFR, TP53
23pulmonary subvalvular stenosis10.5EGFR, TP53
24adult astrocytic tumour10.5EGFR, TP53
25head and neck carcinoma10.4KIT, TP53
26homocystinuria10.4EGFR, TP53
27sebaceous breast carcinoma10.4KIT, TP53
28pulmonary immaturity10.4TP53, VIM
29sensory system cancer10.4KIT, TP53
30integumentary system benign neoplasm10.4EGFR, TP53
31juvenile astrocytoma10.4EGFR, TP53
32cervical large cell neuroendocrine carcinoma10.4EGFR, KIT
33spondylitis10.4EGFR, KRT14
34distal monosomy 9p10.4EGFR, VIM
35liver rhabdomyosarcoma10.4KIT, TP53
36malignant teratocarcinosarcoma10.4KIT, VIM
37nasal cavity squamous cell carcinoma10.4EGFR, KRT14
38cleft lip and palate malrotation cardiopathy10.4EGFR, TP53
39breast papillomatosis10.4KIT, VIM
40brain stem ependymoma10.4TP53, VIM
41benign mesothelioma10.4KIT, VIM
42epidermal nevus vitamin d resistant rickets10.4EGFR, VIM
43mixed liposarcoma10.4KIT, VIM
44nerve root neoplasm10.3KIT, VIM
45breast adenomyoepithelial adenosis10.3TP53, VIM
46skin pilomatrix carcinoma10.3KRT14, KRT8
47lymphoepithelioma-like carcinoma10.3EGFR, KRT14
48epidermolysis bullosa acquisita10.3KIT, VIM
49ovarian clear cell adenocarcinoma10.3KRT14, KRT8
50lymphoplasmacyte-rich meningioma10.3KRT8, VIM

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to pleomorphic carcinoma

Symptoms for Pleomorphic Carcinoma

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Drugs & Therapeutics for Pleomorphic Carcinoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial of Radiotherapy and Panitumumab in Salivary Gland MalignanciesWithdrawnNCT00984217Phase 2

Search NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

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Anatomical Context for Pleomorphic Carcinoma

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MalaCards organs/tissues related to Pleomorphic Carcinoma:

33
Lung, Breast, Prostate, Salivary gland, Pancreas, Brain, Ovary

Animal Models for Pleomorphic Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

38 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0EGFR, KRT14, TP53, ZEB1
2MP:00053718.4EGFR, KIT, PDGFRA, TP53, ZEB1
3MP:00053778.4EGFR, KIT, KRT14, TP53, ZEB1
4MP:00053918.1EGFR, KIT, KRT14, TP53, VIM, ZEB1
5MP:00053797.8EGFR, KIT, KRT14, PDGFRA, TP53, ZEB1
6MP:00020067.8EGFR, KIT, KRT14, PDGFRA, TP53, ZEB1
7MP:00011867.8EGFR, KIT, KRT14, PDGFRA, TP53, ZEB1
8MP:00107717.8EGFR, KIT, KRT14, PDGFRA, TP53, ZEB1
9MP:00053697.8EGFR, KIT, PDGFRA, TP53, VIM, ZEB1
10MP:00053827.7EGFR, KIT, KRT14, PDGFRA, TP53, ZEB1
11MP:00053807.6EGFR, KIT, KRT8, PDGFRA, TP53, VIM
12MP:00053817.3EGFR, KIT, KRT14, KRT8, PDGFRA, TP53
13MP:00053857.3EGFR, KIT, KRT8, PDGFRA, TP53, VIM
14MP:00053887.3EGFR, KIT, KRT14, PDGFRA, TP53, VIM
15MP:00053896.9EGFR, KIT, KRT14, KRT8, PDGFRA, TP53
16MP:00053766.8EGFR, KIT, KRT14, KRT8, PDGFRA, TP53
17MP:00107686.7EGFR, KIT, KRT14, KRT8, PDGFRA, TP53
18MP:00053786.7EGFR, KIT, KRT14, KRT8, PDGFRA, TP53
19MP:00053876.6EGFR, KIT, KRT14, KRT8, PDGFRA, TP53
20MP:00053976.6EGFR, KIT, KRT14, KRT8, PDGFRA, TP53

Publications for Pleomorphic Carcinoma

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Articles related to Pleomorphic Carcinoma:

(show top 50)    (show all 113)
idTitleAuthorsYear
1
Pleomorphic Carcinoma of the Lung: Relationship Between CT Findings and Prognosis. (27144416)
2016
2
Pemetrexed and bevacizumab-containing chemotherapy for pleomorphic carcinoma of the lung. (27073676)
2016
3
Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas. (26329973)
2015
4
Comparative analysis of tumor angiogenesis and clinical features of 55 cases of pleomorphic carcinoma and adenocarcinoma of the lung. (25550577)
2015
5
Anaplastic Lymphoma Kinase (ALK) Rearrangement-positive Lung Cancer with Transformation to Pleomorphic Carcinoma. (26568007)
2015
6
Retrospective analysis of the efficacy of chemotherapy and molecular targeted therapy for advanced pulmonary pleomorphic carcinoma. (26682906)
2015
7
Response to Crizotinib and Clinical Outcome in ALK-Rearranged Pulmonary Pleomorphic Carcinoma. (25898961)
2015
8
Unexpectedly long intravenous and intracardiac extension of a small-sized pulmonary pleomorphic carcinoma. (25590004)
2014
9
Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung. (24846683)
2014
10
A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity. (25123545)
2014
11
Bevacizumab for critical brain metastases in a patient with pulmonary pleomorphic carcinoma. (25130117)
2014
12
Recurrent intussusception caused by intestinal metastasis of pulmonary pleomorphic carcinoma. (24924845)
2014
13
Pulmonary pleomorphic carcinoma with rapid progression. (24532631)
2013
14
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. (23696935)
2013
15
Resected pleomorphic carcinoma of the gallbladder. (23341796)
2012
16
Tumor angiogenesis in 75 cases of pleomorphic carcinoma of the lung. (22843911)
2012
17
Colonic metastases from pleomorphic carcinoma of the lung presenting as an ileocecal intussusception. (21991496)
2011
18
Pleomorphic carcinoma of the lung arising in a patient with Li-Fraumeni syndrome: report of a case. (21626334)
2011
19
Pleomorphic carcinoma of the lung with intrapulmonary aerogenic metastases on FDG PET. (20706051)
2010
20
Clinical characteristics of pleomorphic carcinoma of the lung. (19577320)
2010
21
Pulmonary pleomorphic carcinoma: a clinicopathological study including EGFR mutation analysis. (20107421)
2010
22
Pulmonary pleomorphic carcinoma: diagnosis using small biopsy specimens. (20736811)
2010
23
Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia. (21165299)
2010
24
Genetic heterogeneity of EGFR mutation in pleomorphic carcinoma of the lung: response to gefitinib and clinical outcome. (19155283)
2009
25
The role of palliative chemotherapy for advanced pulmonary pleomorphic carcinoma. (18989796)
2009
26
Esophageal polypoidal mass: presentation of an uncommon pleomorphic carcinoma. (19750865)
2009
27
Pleomorphic carcinoma of the lung with uncommon initial manifestation of intestinal perforation]. (19601528)
2009
28
Pleomorphic carcinoma with osteoclastic giant cells of the breast: immunohistochemical differentiation between coexisting neoplastic and reactive giant cells. (19154262)
2009
29
Pleomorphic carcinoma of the lung in which the sarcomatous element grew rapidly: a case report. (19471225)
2009
30
Pleomorphic carcinoma of the lung: clinicopathologic characteristics of 70 cases. (18769330)
2008
31
Pleomorphic carcinoma of the lung expressing podoplanin and calretinin. (19067851)
2008
32
F-18 FDG PET imaging in a patient with granulocyte colony stimulating factor producing pulmonary pleomorphic carcinoma. (18645378)
2008
33
Long-term survival in two cases of resected gastric metastasis of pulmonary pleomorphic carcinoma. (18594328)
2008
34
Pleomorphic carcinoma of the lung: a report of six cases. (17978928)
2007
35
Expression of caveolin-1 in pleomorphic carcinoma of the lung is correlated with a poor prognosis. (16334154)
2005
36
Personal experience in surgical management of pulmonary pleomorphic carcinoma. (15511465)
2004
37
Metastatic pleomorphic carcinoma of lung presenting as abdominal pain. (15622698)
2004
38
Pleomorphic carcinoma of lung: comparison of CT features and pathologic findings. (15215543)
2004
39
Pleomorphic carcinomas of the lung show a selective distribution of gene products involved in cell differentiation, cell cycle control, tumor growth, and tumor cell motility: a clinicopathologic and immunohistochemical study of 31 cases. (12960804)
2003
40
Pleomorphic carcinoma of the breast: clinicopathological analysis of 26 cases of an unusual high-grade phenotype of ductal carcinoma. (10849092)
2000
41
Pathological study of the pleomorphic carcinoma of the lung]. (11866944)
2000
42
A case of pleomorphic carcinoma of the pancreas showing sequential histological change by immunohistochemical study. (7594772)
1995
43
Pleomorphic carcinoma of the gallbladder: report of a case. (1803718)
1991
44
Surgical treatment of pleomorphic carcinoma of the pancreas. (2190511)
1990
45
Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells expressing an epithelial-associated antigen detected by monoclonal antibody 44-3A6. (3254809)
1988
46
Pleomorphic carcinoma of the pancreas: computed-tomographic, sonographic, and pathologic findings. (3880902)
1985
47
Pleomorphic carcinoma of the gallbladder: case report and ultrastructural study. (6539521)
1984
48
Pleomorphic carcinoma of the thyroid. (20312831)
1977
49
A functioning pleomorphic carcinoma of the thyroid. (1277059)
1976
50
Pleomorphic carcinoma of the larynx. (5643249)
1968

Variations for Pleomorphic Carcinoma

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Expression for genes affiliated with Pleomorphic Carcinoma

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Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for genes affiliated with Pleomorphic Carcinoma

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Pathways related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathwaysScoreTop Affiliating Genes
19.8EGFR, TP53
29.8EGFR, TP53
39.7KRT8, TP53
49.3EGFR, PDGFRA
59.3EGFR, PDGFRA
6
Show member pathways
9.3EGFR, KIT, TP53
79.2EGFR, TP53, VIM
89.1TP53, VIM, ZEB1
98.9EGFR, PDGFRA, TP53
10
Show member pathways
8.9EGFR, PDGFRA, TP53
11
Show member pathways
8.9EGFR, PDGFRA, TP53
128.9EGFR, PDGFRA, TP53
13
Show member pathways
8.9KRT14, KRT8, VIM
148.9EGFR, KIT, PDGFRA
15
Show member pathways
8.9EGFR, KIT, PDGFRA
16
Show member pathways
8.5EGFR, KIT, PDGFRA, TP53
178.5EGFR, KIT, PDGFRA, TP53
188.5EGFR, KIT, PDGFRA, TP53
198.5EGFR, KIT, PDGFRA, TP53
207.9EGFR, PDGFRA, TP53, VIM, ZEB1

GO Terms for genes affiliated with Pleomorphic Carcinoma

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Cellular components related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.4KRT14, KRT8

Biological processes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAP kinase activityGO:004340610.1EGFR, KIT
2phosphatidylinositol phosphorylationGO:004685410.0EGFR, KIT
3positive regulation of phospholipase C activityGO:00108639.7KIT, PDGFRA
4embryonic skeletal system morphogenesisGO:00487049.6PDGFRA, ZEB1
5positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.5KIT, PDGFRA
6positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.3KIT, PDGFRA
7phosphatidylinositol-mediated signalingGO:00480159.3EGFR, KIT, PDGFRA
8cell chemotaxisGO:00603269.2KIT, PDGFRA
9transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.2EGFR, KIT, PDGFRA
10protein autophosphorylationGO:00467779.1EGFR, KIT, PDGFRA
11insulin receptor signaling pathwayGO:00082868.9EGFR, KIT, PDGFRA
12vascular endothelial growth factor receptor signaling pathwayGO:00480108.6EGFR, KIT, PDGFRA

Molecular functions related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:00316259.9EGFR, TP53
2protein tyrosine kinase activityGO:00047138.9EGFR, KIT, PDGFRA

Sources for Pleomorphic Carcinoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet