MCID: PLM016
MIFTS: 36

Pleomorphic Carcinoma malady

Category: Cancer diseases

Aliases & Classifications for Pleomorphic Carcinoma

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Aliases & Descriptions for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:5662
SNOMED-CT62 16741004
NCIt45 C4094

Summaries for Pleomorphic Carcinoma

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Disease Ontology:11 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary: Pleomorphic Carcinoma is related to lung cancer and pseudounicornuate uterus. An important gene associated with Pleomorphic Carcinoma is NKX2-1 (NK2 Homeobox 1), and among its related pathways are Bladder cancer and Gastric cancer network 2. Affiliated tissues include lung, pancreas and salivary gland, and related mouse phenotypes are Decreased substrate adherent cell growth and Increased cell death HMECs cells.

Related Diseases for Pleomorphic Carcinoma

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Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer28.2ALK, EGFR, KRT18, NKX2-1, TP53
2pseudounicornuate uterus10.5EGFR, NKX2-1
33q26q27 microdeletion syndrome10.5ALK, EGFR
4peptic ulcer disease10.5EGFR, TP53
5tamoxifen-related endometrial lesion10.5EGFR, TP53
6yolk sac tumor of central nervous system10.5EGFR, TP53
7cerebellum cancer10.5EGFR, TP53
8adenosquamous carcinoma10.4ALK, EGFR
9uterine corpus epithelioid leiomyosarcoma10.4EGFR, TP53
10external ear disease10.4NKX2-1, TP53
11herpes simplex10.4EGFR, TP53
12glucocorticoid-induced osteoporosis10.4ALK, TP53
13adult teratoma10.4NKX2-1, TP53
14stampe sorensen syndrome10.4EGFR, TP53
15ossifying fibromyxoid tumor10.4EGFR, PGR
16her2-receptor negative breast cancer10.4EGFR, PGR
17early myoclonic encephalopathy10.4EGFR, TP53
18bone remodeling disease10.4NKX2-1, TP53
19glottis verrucous carcinoma10.4EGFR, PGR
20aggressive digital papillary adenocarcinoma10.4ALK, TP53
21bladder colonic type adenocarcinoma10.4EGFR, PGR
22mature b-cell neoplasm10.4EGFR, TP53
23cervical benign neoplasm10.4EGFR, TP53
24anomalous left coronary artery from the pulmonary artery10.4EGFR, PGR
25apocrine adenocarcinoma10.4EGFR, PGR
26lipomatosis10.4EGFR, TP53
27mast-cell sarcoma10.4KRT8, NKX2-1
28mesenchymoma10.4NKX2-1, TP53
29actinic keratosis10.4EGFR, TP53
30grade iii astrocytoma10.4EGFR, TP53
31secondary syphilis10.3EGFR, KRT8
32serous cystadenocarcinoma10.3NKX2-1, PGR
33poliomyelitis10.3NKX2-1, PGR
34mixed cell type kidney wilms' tumor10.3PGR, TP53
35camera marugo cohen syndrome10.3KRT8, TP53
36prolapse of lacrimal gland10.3EGFR, PGR
37mantle cell lymphoma10.3EGFR, TP53
38simple partial epilepsy10.3PGR, TP53
39frontal sinus inverted papilloma10.3PGR, TP53
40integumentary system cancer10.3EGFR, TP53
41uterine body mixed cancer10.3PGR, TP53
42central nervous system germinoma10.3PGR, TP53
43mental retardation, autosomal recessive 4910.3KRT8, TP53
44fallopian tube mucinous adenocarcinoma10.3EGFR, TP53
45cell type benign neoplasm10.3PGR, TP53
46cartilage cancer10.3PGR, TP53
47extrahepatic bile duct adenocarcinoma10.3KRT8, TP53
48pancreatic cancer10.3KRT8, TP53
49leiomyosarcoma10.2PGR, TP53
50breast adenoma10.2PGR, TP53

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to pleomorphic carcinoma

Symptoms & Phenotypes for Pleomorphic Carcinoma

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GenomeRNAi Phenotypes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00193-A-39.7ALK, EGFR, KIT
2GR00103-A-09.3EGFR, KRT18, PGR, TP53

MGI Mouse Phenotypes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

41 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.2ALK, EGFR, KIT, TP53
2MP:00053818.8EGFR, KIT, KRT8, NKX2-1, TP53
3MP:00053888.8ALK, EGFR, KIT, NKX2-1, TP53
4MP:00030128.8EGFR, KIT, NKX2-1, PGR, TP53
5MP:00107718.7ALK, EGFR, KIT, PGR, TP53
6MP:00053708.5EGFR, KIT, KRT18, KRT8, TP53
7MP:00053798.4ALK, EGFR, KIT, NKX2-1, PGR, TP53
8MP:00020068.4ALK, EGFR, KIT, NKX2-1, PGR, TP53
9MP:00053858.3EGFR, KIT, KRT8, NKX2-1, PGR, TP53
10MP:00053808.0EGFR, KIT, KRT18, KRT8, PGR, TP53
11MP:00053767.9ALK, EGFR, KIT, KRT8, NKX2-1, PGR
12MP:00053897.8ALK, EGFR, KIT, KRT8, NKX2-1, PGR
13MP:00053787.8ALK, EGFR, KIT, KRT18, KRT8, NKX2-1
14MP:00053907.5ALK, EGFR, KIT, NKX2-1, PGR, TP53
15MP:00107687.2ALK, EGFR, KIT, KRT18, KRT8, NKX2-1

Drugs & Therapeutics for Pleomorphic Carcinoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial of Radiotherapy and Panitumumab in Salivary Gland MalignanciesWithdrawnNCT00984217Phase 2

Search NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

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Anatomical Context for Pleomorphic Carcinoma

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MalaCards organs/tissues related to Pleomorphic Carcinoma:

36
Lung, Pancreas, Salivary gland, Colon, Thyroid, Brain, Tongue

Publications for Pleomorphic Carcinoma

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Articles related to Pleomorphic Carcinoma:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Pemetrexed and bevacizumab-containing chemotherapy for pleomorphic carcinoma of the lung. (27073676)
2016
2
Pseudoprogression" of Pulmonary Pleomorphic Carcinoma during Nivolumab Therapy. (27189927)
2016
3
High co-expression of PD-L1 and HIF-1I+ correlates with tumour necrosis in pulmonary pleomorphic carcinoma. (27107327)
2016
4
Pleomorphic Carcinoma of the Lung: Relationship Between CT Findings and Prognosis. (27144416)
2016
5
P1.27: A Clinicopathological Study of ResectedA Pulmonary Pleomorphic Carcinoma: Track: Advanced NSCLC. (27676513)
2016
6
Pleomorphic Carcinoma of the Colon: Morphological and Immunohistochemical Findings. (27462191)
2016
7
A rare primary pulmonary tumor with difficult diagnosis: pleomorphic carcinoma. (27525610)
2016
8
Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas. (26329973)
2015
9
Anaplastic Lymphoma Kinase (ALK) Rearrangement-positive Lung Cancer with Transformation to Pleomorphic Carcinoma. (26568007)
2015
10
Response to Crizotinib and Clinical Outcome in ALK-Rearranged Pulmonary Pleomorphic Carcinoma. (25898961)
2015
11
Successful treatment of two consecutive cases of pulmonary pleomorphic carcinoma with platinum chemotherapy. (26722286)
2015
12
Clinicoradiological outcomes of 33 cases of surgically resected pulmonary pleomorphic carcinoma: correlation with prognostic indicators. (25994197)
2015
13
Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung. (26345631)
2015
14
Clinicopathological analysis of pleomorphic carcinoma of the lung: diffuse ZEB1 expression predicts poor survival. (25479687)
2015
15
Comparative analysis of tumor angiogenesis and clinical features of 55 cases of pleomorphic carcinoma and adenocarcinoma of the lung. (25550577)
2015
16
Retrospective analysis of the efficacy of chemotherapy and molecular targeted therapy for advanced pulmonary pleomorphic carcinoma. (26682906)
2015
17
Tumor-related gene expression levels in pulmonary pleomorphic carcinoma. (26031756)
2015
18
EGFR and KRAS mutations in pulmonary pleomorphic carcinoma and their correlation with clinicopathologic features. (26199566)
2015
19
Promising effect of chemotherapy with bevacizumab for patients with pulmonary pleomorphic carcinoma: Two case reports and a literature review. (26521107)
2015
20
A Rare Case of Pleomorphic Carcinoma of the Lung Harboring an Anaplastic Lymphoma Kinase (ALK) Rearrangement. (26521903)
2015
21
A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity. (25123545)
2014
22
Bevacizumab for critical brain metastases in a patient with pulmonary pleomorphic carcinoma. (25130117)
2014
23
A case of synchronous double primary lung cancer presenting with pleomorphic carcinoma and adenocarcinoma. (25553415)
2014
24
Pulmonary pleomorphic carcinoma with multiple metastases to the right posterior knee complicated by paraneoplastic hypercalcemia. (24396467)
2014
25
Pleomorphic carcinoma of breast: a case report and review of literature. (25197400)
2014
26
Pulmonary pleomorphic carcinoma detected as a result of pneumothorax and the subsequent occurrence of multiple cystic metastases. (25214846)
2014
27
Pleomorphic Carcinoma Showing Rapid Growth, Multiple Metastases, and Intestinal Perforation. (24492166)
2014
28
Unexpectedly long intravenous and intracardiac extension of a small-sized pulmonary pleomorphic carcinoma. (25590004)
2014
29
Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung. (24846683)
2014
30
Recurrent intussusception caused by intestinal metastasis of pulmonary pleomorphic carcinoma. (24924845)
2014
31
Pulmonary Pleomorphic Carcinoma Metastasis to the Midfoot. (24840733)
2014
32
Long-term survival in a case of pleomorphic carcinoma with a brain metastasis. (25566055)
2014
33
Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine. (25400187)
2014
34
Sarcomatous Components May Predict Prognosis in Patients with Pulmonary Pleomorphic Carcinoma. (25423314)
2014
35
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. (23696935)
2013
36
Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC. (23651662)
2013
37
Multiple Cytokines-Producing Pleomorphic Carcinoma of Lung with Metastasis to the Small Intestine. (24200664)
2013
38
Pulmonary pleomorphic carcinoma with rapid progression. (24532631)
2013
39
Long-term remission achieved via combined chemotherapy and radiotherapy in a non-resectable granulocyte colony-stimulating factor producing pleomorphic carcinoma of the lung. (24088763)
2013
40
Spindle Cell Component in Pleomorphic Carcinoma Showing Polypoid Growth in the Pulmonary Vein. (23903706)
2013
41
Intussusception Caused by Intestinal Metastasis from Lung Pleomorphic Carcinoma. (23903709)
2013
42
Resected pleomorphic carcinoma of the gallbladder. (23341796)
2012
43
Clinicopathological characteristics of surgically resected pulmonary pleomorphic carcinoma. (22228848)
2012
44
Tumor angiogenesis in 75 cases of pleomorphic carcinoma of the lung. (22843911)
2012
45
Pulmonary pleomorphic carcinoma producing granulocyte-macrophage colony-stimulating factor: report of a case. (22068679)
2012
46
A case of pleomorphic carcinoma of the lung suspected from infectious bulla. (23087315)
2012
47
Pleomorphic carcinoma of the breast with expression of macrophage markers: report of two cases. (22726069)
2012
48
Pleomorphic carcinoma of the lung arising in a patient with Li-Fraumeni syndrome: report of a case. (21626334)
2011
49
Molecular profiles of EGFR, K-ras, c-met, and FGFR in pulmonary pleomorphic carcinoma, a rare lung malignancy. (21626008)
2011
50
Two consecutive cases of platinum-refractory pulmonary pleomorphic carcinoma that showed dramatic responses to MAID (mesna, doxorubicin, ifosfamide and dacarbazine) chemotherapy. (20926411)
2011

Variations for Pleomorphic Carcinoma

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Expression for genes affiliated with Pleomorphic Carcinoma

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Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for genes affiliated with Pleomorphic Carcinoma

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GO Terms for genes affiliated with Pleomorphic Carcinoma

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Biological processes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex cell migrationGO:002179510.4EGFR, NKX2-1
2extrinsic apoptotic signaling pathwayGO:009719110.0KRT18, KRT8
3hepatocyte apoptotic processGO:009728410.0KRT18, KRT8
4peptidyl-tyrosine phosphorylationGO:00181089.4ALK, EGFR, KIT
5protein autophosphorylationGO:00467778.9ALK, EGFR, KIT

Molecular functions related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.4EGFR, NKX2-1, PGR, TP53
2protein tyrosine kinase activityGO:00047139.3ALK, EGFR, KIT
3transmembrane receptor protein tyrosine kinase activityGO:00047148.9ALK, EGFR, KIT

Sources for Pleomorphic Carcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet