MCID: PLM016
MIFTS: 42

Pleomorphic Carcinoma malady

Cancer diseases category
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Summaries for Pleomorphic Carcinoma

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards: Pleomorphic Carcinoma is related to adenocarcinoma and intussusception. An important gene associated with Pleomorphic Carcinoma is KRT14 (keratin 14), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Cell adhesion Integrin mediated cell adhesion and migration. The compounds b 723 and urea have been mentioned in the context of this disorder. Affiliated tissues include lung, pancreas and breast, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Pleomorphic Carcinoma

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Sources:
8Disease Ontology, 62UMLS, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

pleomorphic carcinoma 8 62


External Ids:

Disease Ontology8 DOID:5662
SNOMED-CT58 16741004
NCIt40 C4094

Related Diseases for Pleomorphic Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma29.9KRT14, NKX2-1, KRT18, CAV1
2intussusception10.3
3thyroiditis10.2
4syringoma10.1KRT14
5angiosarcoma10.0KRT18, KRT14
6adenoameloblastoma10.0KRT18, KRT14
7thymus cancer10.0NKX2-1, KRT18
8epidermolysis bullosa simplex10.0KRT14, DES
9neuroendocrine carcinoma10.0KRT18, NKX2-1
10transitional cell carcinoma10.0KRT18, KRT14
11synovial sarcoma10.0KRT14, DES
12sex cord-gonadal stromal tumor10.0NKX2-1, DES
13abrikosov's tumor10.0DES, NKX2-1
14spindle cell carcinoma10.0
15gynecomastia10.0
16hypercalcemia10.0
17li-fraumeni syndrome10.0
18large cell carcinoma10.0
19small cell carcinoma10.0
20bronchopneumonia10.0
21esophagitis10.0
22intestinal perforation10.0
23mediastinitis10.0
24malignant mesothelioma10.0NKX2-1, DES
25non-small cell lung carcinoma10.0KRT18, NKX2-1
26wilms tumor10.0NKX2-1, DES
27factor v leiden thrombophilia10.0KRT14, NKX2-1
28oral cancer10.0KRT14, CAV1
29cork-handlers' disease10.0KRT18, NKX2-1
30bladder carcinoma10.0CAV1, KRT18
31papillary thyroid carcinoma10.0NKX2-1, CAV1
32squamous cell carcinoma of the head and neck10.0KRT18, KRT14
33papillary carcinoma10.0KRT14, KRT18, NKX2-1
34chordoma10.0DES, KRT18, KRT14
35breast cancer10.0KRT14, CAV1
36pleomorphic adenoma10.0KRT18, DES, KRT14
37benign mesothelioma10.0NKX2-1, KRT14, DES
38noonan syndrome10.0DES, CAV1
39oxyphilic adenoma10.0CAV1, KRT14, KRT18
40fibrosarcoma10.0DES, CAV1
41psoriasis10.0CAV1, KRT14, KRT18
42retinoblastoma10.0KRT14, KRT18, CAV1
43muscular dystrophy10.0DES, CAV1, KRT14
44lung adenocarcinoma10.0CAV1, KRT18, NKX2-1
45colorectal cancer9.9CAV1, KRT18, KRT14
46liver cirrhosis9.9KRT18, CAV1
47lung small cell carcinoma9.9CAV1, NKX2-1, KRT14, KRT18
48kidney cancer9.9KRT14, KRT18, CAV1, NKX2-1
49adenoma9.9NKX2-1, CAV1, KRT14, KRT18
50hepatocellular carcinoma9.9NKX2-1, CAV1, KRT18, KRT14

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to pleomorphic carcinoma

Symptoms for Pleomorphic Carcinoma

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Drugs & Therapeutics for Pleomorphic Carcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pleomorphic Carcinoma

Search NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

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Anatomical Context for Pleomorphic Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Pleomorphic Carcinoma:

33
Lung, Pancreas, Breast, Thyroid, Small intestine, Colon, Tongue

Animal Models for Pleomorphic Carcinoma or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7CAV1, NKX2-1, KRT14
2MP:00053818.7KRT14, NKX2-1, CAV1
3MP:00053888.4KRT14, NKX2-1, CAV1
4MP:00053788.1CAV1, NKX2-1, KRT14, KRT18
5MP:00107687.6KRT18, KRT14, NKX2-1, CAV1, DES

Publications for Pleomorphic Carcinoma

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52PubMed
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Articles related to Pleomorphic Carcinoma:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. (23696935)
2013
2
Long-term remission achieved via combined chemotherapy and radiotherapy in a non-resectable granulocyte colony-stimulating factor producing pleomorphic carcinoma of the lung. (24088763)
2013
3
Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC. (23651662)
2013
4
Resected pleomorphic carcinoma of the gallbladder. (23341796)
2012
5
Tumor angiogenesis in 75 cases of pleomorphic carcinoma of the lung. (22843911)
2012
6
Pulmonary pleomorphic carcinoma producing granulocyte-macrophage colony-stimulating factor: report of a case. (22068679)
2012
7
Colonic metastases from pleomorphic carcinoma of the lung presenting as an ileocecal intussusception. (21991496)
2011
8
Pleomorphic carcinoma of the lung arising in a patient with Li-Fraumeni syndrome: report of a case. (21626334)
2011
9
Clinical characteristics of pleomorphic carcinoma of the lung. (19577320)
2010
10
Pulmonary pleomorphic carcinoma: a clinicopathological study including EGFR mutation analysis. (20107421)
2010
11
Pulmonary pleomorphic carcinoma: diagnosis using small biopsy specimens. (20736811)
2010
12
Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia. (21165299)
2010
13
Pleomorphic carcinoma of the breast in a 17-year-old woman. (20340005)
2010
14
Genetic heterogeneity of EGFR mutation in pleomorphic carcinoma of the lung: response to gefitinib and clinical outcome. (19155283)
2009
15
The role of palliative chemotherapy for advanced pulmonary pleomorphic carcinoma. (18989796)
2009
16
Esophageal polypoidal mass: presentation of an uncommon pleomorphic carcinoma. (19750865)
2009
17
Pleomorphic carcinoma of the lung with uncommon initial manifestation of intestinal perforation]. (19601528)
2009
18
Pleomorphic carcinoma with osteoclastic giant cells of the breast: immunohistochemical differentiation between coexisting neoplastic and reactive giant cells. (19154262)
2009
19
Pleomorphic carcinoma of the lung in which the sarcomatous element grew rapidly: a case report. (19471225)
2009
20
Two cases of pleomorphic carcinoma with severe systemic inflammation]. (19764522)
2009
21
Pleomorphic carcinoma of the lung: clinicopathologic characteristics of 70 cases. (18769330)
2008
22
Pleomorphic carcinoma of the lung expressing podoplanin and calretinin. (19067851)
2008
23
F-18 FDG PET imaging in a patient with granulocyte colony stimulating factor producing pulmonary pleomorphic carcinoma. (18645378)
2008
24
Long-term survival in two cases of resected gastric metastasis of pulmonary pleomorphic carcinoma. (18594328)
2008
25
Pleomorphic carcinoma of the lung: a report of six cases. (17978928)
2007
26
Palliative chemotherapy for pulmonary pleomorphic carcinoma. (17574296)
2007
27
Expression of caveolin-1 in pleomorphic carcinoma of the lung is correlated with a poor prognosis. (16334154)
2005
28
Pleomorphic carcinoma of the lung associated with loss of heterozygosity of p53 gene. (15888975)
2005
29
Pleomorphic carcinoma of the lung with mediastinal extension following malignant lymphoma: report of a case. (16249854)
2005
30
Personal experience in surgical management of pulmonary pleomorphic carcinoma. (15511465)
2004
31
Metastatic pleomorphic carcinoma of lung presenting as abdominal pain. (15622698)
2004
32
Pleomorphic carcinoma of lung: comparison of CT features and pathologic findings. (15215543)
2004
33
Resection of a pleomorphic carcinoma of the lung invading the descending aorta. (15173751)
2004
34
Pleomorphic carcinomas of the lung show a selective distribution of gene products involved in cell differentiation, cell cycle control, tumor growth, and tumor cell motility: a clinicopathologic and immunohistochemical study of 31 cases. (12960804)
2003
35
Pleomorphic carcinoma of the breast: clinicopathological analysis of 26 cases of an unusual high-grade phenotype of ductal carcinoma. (10849092)
2000
36
Pathological study of the pleomorphic carcinoma of the lung]. (11866944)
2000
37
Pleomorphic carcinoma of the pancreas: reappraisal of surgical resection. (9672350)
1998
38
A case of pleomorphic carcinoma of the pancreas showing sequential histological change by immunohistochemical study. (7594772)
1995
39
Pleomorphic carcinoma (spindle and giant cell) of the lung. (7968314)
1994
40
Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells. (8113629)
1993
41
Pleomorphic carcinoma of the gallbladder: report of a case. (1803718)
1991
42
Surgical treatment of pleomorphic carcinoma of the pancreas. (2190511)
1990
43
Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells expressing an epithelial-associated antigen detected by monoclonal antibody 44-3A6. (3254809)
1988
44
Pleomorphic carcinoma of the pancreas: computed-tomographic, sonographic, and pathologic findings. (3880902)
1985
45
Pleomorphic carcinoma of the gallbladder: case report and ultrastructural study. (6539521)
1984
46
Pleomorphic carcinoma of the thyroid. (20312831)
1977
47
A functioning pleomorphic carcinoma of the thyroid. (1277059)
1976
48
Pleomorphic carcinoma of the larynx. (5643249)
1968
49
Total pancreatectomy for pleomorphic carcinoma. A five-year cure. (5902860)
1966
50
FOUR SEPARATE TUMOUR CLONES DERIVED FROM A TRANSPLANTABLE PLEOMORPHIC CARCINOMA OF THE LUNG IN A HETEROZYGOUS MOUSE. (14263471)
1965

Variations for Pleomorphic Carcinoma

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Expression for genes affiliated with Pleomorphic Carcinoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleomorphic Carcinoma

Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for genes affiliated with Pleomorphic Carcinoma

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 5Cell Signaling Technology
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Pathways related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5KRT18, KRT14
2
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.1NKX2-1, CAV1
39.1KRT18, CAV1
48.5KRT18, CAV1, DES

Compounds for genes affiliated with Pleomorphic Carcinoma

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45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1b 723459.6DES, NKX2-1
2urea45 24 1111.6KRT18, KRT14
3p002459.4DES, KRT18
4ganglioside459.3CAV1, DES
5mucicarmine459.3DES, NKX2-1, KRT14
6bromodeoxyuridine459.2DES, KRT14, KRT18
7formaldehyde45 2410.1KRT18, NKX2-1, DES
8egcg459.1KRT18, CAV1
9phosphatidylserine45 29 1111.1KRT18, CAV1
10oligonucleotide458.9KRT18, NKX2-1, CAV1
11gold458.9KRT18, CAV1, DES
12dexamethasone45 51 29 1111.8CAV1, NKX2-1, KRT18
13alanine458.8KRT18, KRT14, CAV1
14doxorubicin45 51 1110.8KRT18, CAV1, DES
15fatty acid458.8KRT18, CAV1, DES
16testosterone45 61 24 1111.8DES, CAV1, KRT18
17arginine458.8KRT14, CAV1, DES
18hematoxylin458.8KRT18, KRT14, NKX2-1, DES
19vegf458.7KRT18, CAV1, DES
20nitric oxide45 24 1110.7DES, CAV1, KRT18
21iron45 249.4KRT18, KRT14, CAV1, DES
22oxygen45 249.4DES, CAV1, KRT18
23glucose458.4DES, CAV1, KRT14, KRT18
24steroid458.3DES, CAV1, NKX2-1, KRT18
25cysteine458.3KRT14, CAV1, DES
26paraffin457.9DES, CAV1, NKX2-1, KRT14, KRT18
27progesterone45 29 61 24 1111.9KRT18, KRT14, NKX2-1, CAV1, DES
28threonine457.9KRT18, KRT14, NKX2-1, CAV1, DES
29estrogen457.9DES, CAV1, NKX2-1, KRT14, KRT18
30retinoic acid45 248.9DES, CAV1, NKX2-1, KRT14, KRT18
31serine457.9DES, CAV1, NKX2-1, KRT14, KRT18
32tyrosine457.9DES, CAV1, NKX2-1, KRT14, KRT18

GO Terms for genes affiliated with Pleomorphic Carcinoma

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16Gene Ontology
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Cellular components related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.5KRT18, KRT14
2intermediate filamentGO:0058828.6KRT18, KRT14, DES

Molecular functions related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.3KRT14, DES
2structural molecule activityGO:0051989.1KRT18, CAV1
3protein bindingGO:0055157.2KRT18, KRT14, NKX2-1, CAV1, DES

Products for genes affiliated with Pleomorphic Carcinoma

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  • Antibodies
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Sources for Pleomorphic Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet