MCID: PLM016
MIFTS: 35

Pleomorphic Carcinoma malady

Cancer diseases category

Aliases & Classifications for Pleomorphic Carcinoma

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Aliases & Descriptions for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 10 65


Classifications:



External Ids:

Disease Ontology10 DOID:5662
SNOMED-CT59 16741004
NCIt42 C4094

Summaries for Pleomorphic Carcinoma

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Disease Ontology:10 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary: Pleomorphic Carcinoma is related to intussusception and adenocarcinoma. An important gene associated with Pleomorphic Carcinoma is EGFR (Epidermal Growth Factor Receptor), and among its related pathways are Bladder cancer and Gastric cancer network 2. Affiliated tissues include lung, pancreas and breast, and related mouse phenotypes are adipose tissue and no phenotypic analysis.

Related Diseases for Pleomorphic Carcinoma

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Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1intussusception10.3
2adenocarcinoma10.3
3bicervical bicornuate uterus and blind hemivagina10.3EGFR, NKX2-1
4ovarian mucinous cystadenocarcinoma10.2EGFR, NKX2-1
5spinal cord disease10.2EGFR, KRT8
6bronchial disease10.2EGFR, KRT14
7trachea adenoid cystic carcinoma10.2KRT8, NKX2-1
8lung cancer10.2
9large cell carcinoma10.2
10intestinal perforation10.2
11thyroiditis10.2
12brain germinoma10.2EGFR, TP53
13fallopian tube clear cell adenocarcinoma10.2EGFR, TP53
14hallucinogen dependence10.2KRT14, KRT8
15brain stem infarction10.2EGFR, TP53
16thyroid cancer, childhood10.2NKX2-1, TP53
17fallopian tube serous papilloma10.2NKX2-1, TP53
18cervical benign neoplasm10.2EGFR, PDGFRA
19calloso-genital dysplasia10.2KRT8, TP53
20odontoma dysphagia syndrome10.2KRT14, KRT8
21mast cell neoplasm10.2NKX2-1, TP53
22acantholytic variant squamous cell breast carcinoma10.2EGFR, TP53
23coronary restenosis10.2NKX2-1, TP53
24osteochondrodysplasia10.2EGFR, TP53
25thymoma10.2EGFR, NKX2-1
26kluver-bucy syndrome10.2KRT14, KRT8
27enophthalmos10.2EGFR, PGR
28estrogen-receptor negative breast cancer10.2EGFR, PGR
29brain medulloblastoma10.2EGFR, TP53
30malignant cystic nephroma10.2EGFR, PGR
31colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas10.2KRT14, KRT8
32microscopic colitis10.2EGFR, PGR
33esophageal adenoid cystic carcinoma10.2EGFR, PGR
34bone peripheral neuroepithelioma10.1KRT8, TP53
35bile duct mucoepidermoid carcinoma10.1KRT14, KRT8
36vulva squamous cell carcinoma10.1EGFR, TP53
37cystitis10.1NKX2-1, TP53
38trichostrongyloidiasis10.1KRT14, KRT8
39polyembryoma of the ovary10.1KRT14, TP53
40soft tissue sarcoma childhood10.1EGFR, TP53
41nasopharyngeal carcinoma10.1KRT8, TP53
42degenerative myopia10.1EGFR, TP53
43follicular dendritic cell sarcoma10.1EGFR, PGR
44anaplastic plasmacytoma10.1EGFR, PDGFRA
45mixed type thymoma10.1PDGFRA, TP53
46gliosarcoma10.1EGFR, TP53
47sarcomatoid basal cell carcinoma10.1KRT14, PGR
48adrenal rest tumor10.1EGFR, PGR
49scoliosis10.1NKX2-1, PGR
50tooth disease10.1EGFR, TP53

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to pleomorphic carcinoma

Symptoms for Pleomorphic Carcinoma

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Drugs & Therapeutics for Pleomorphic Carcinoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial of Radiotherapy and Panitumumab in Salivary Gland MalignanciesWithdrawnNCT00984217Phase 2

Search NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

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Anatomical Context for Pleomorphic Carcinoma

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MalaCards organs/tissues related to Pleomorphic Carcinoma:

33
Lung, Pancreas, Breast, Brain, Thyroid, Small intestine, Colon

Animal Models for Pleomorphic Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

38 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7EGFR, KRT14, TP53, ZEB1
2MP:00030128.6EGFR, NKX2-1, PDGFRA, PGR, TP53
3MP:00011868.4EGFR, KRT14, PDGFRA, TP53, ZEB1
4MP:00053828.2EGFR, KRT14, PDGFRA, TP53, ZEB1
5MP:00053718.1EGFR, PDGFRA, PGR, TP53, ZEB1
6MP:00053698.0EGFR, PDGFRA, PGR, TP53, ZEB1
7MP:00053848.0EGFR, KRT14, NKX2-1, PDGFRA, PGR, TP53
8MP:00053907.8EGFR, NKX2-1, PDGFRA, PGR, TP53, ZEB1
9MP:00053887.6EGFR, KRT14, NKX2-1, PDGFRA, TP53, ZEB1
10MP:00053807.6EGFR, KRT8, PDGFRA, PGR, TP53, ZEB1
11MP:00053817.4EGFR, KRT14, KRT8, NKX2-1, PDGFRA, TP53
12MP:00107717.3EGFR, KRT14, PDGFRA, PGR, TP53, ZEB1
13MP:00053797.3EGFR, NKX2-1, PDGFRA, PGR, TP53, ZEB1
14MP:00053787.2EGFR, KRT14, KRT8, NKX2-1, PDGFRA, TP53
15MP:00053857.2EGFR, KRT8, NKX2-1, PDGFRA, PGR, TP53
16MP:00020066.9EGFR, KRT14, NKX2-1, PDGFRA, PGR, TP53
17MP:00053766.9EGFR, KRT14, NKX2-1, PDGFRA, PGR, TP53
18MP:00053876.8EGFR, KRT14, KRT8, PDGFRA, PGR, TP53
19MP:00053976.7EGFR, KRT14, KRT8, PDGFRA, PGR, TP53
20MP:00107686.6EGFR, KRT14, KRT8, NKX2-1, PDGFRA, PGR
21MP:00053896.1EGFR, KRT14, KRT8, NKX2-1, PDGFRA, PGR

Publications for Pleomorphic Carcinoma

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Articles related to Pleomorphic Carcinoma:

(show top 50)    (show all 103)
idTitleAuthorsYear
1
Comparative analysis of tumor angiogenesis and clinical features of 55 cases of pleomorphic carcinoma and adenocarcinoma of the lung. (25550577)
2015
2
Anaplastic Lymphoma Kinase (ALK) Rearrangement-positive Lung Cancer with Transformation to Pleomorphic Carcinoma. (26568007)
2015
3
Tumor-related gene expression levels in pulmonary pleomorphic carcinoma. (26031756)
2015
4
Unexpectedly long intravenous and intracardiac extension of a small-sized pulmonary pleomorphic carcinoma. (25590004)
2014
5
Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung. (24846683)
2014
6
A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity. (25123545)
2014
7
Bevacizumab for critical brain metastases in a patient with pulmonary pleomorphic carcinoma. (25130117)
2014
8
Pulmonary pleomorphic carcinoma with rapid progression. (24532631)
2013
9
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. (23696935)
2013
10
Long-term remission achieved via combined chemotherapy and radiotherapy in a non-resectable granulocyte colony-stimulating factor producing pleomorphic carcinoma of the lung. (24088763)
2013
11
Resected pleomorphic carcinoma of the gallbladder. (23341796)
2012
12
Tumor angiogenesis in 75 cases of pleomorphic carcinoma of the lung. (22843911)
2012
13
Colonic metastases from pleomorphic carcinoma of the lung presenting as an ileocecal intussusception. (21991496)
2011
14
Pleomorphic carcinoma of the lung arising in a patient with Li-Fraumeni syndrome: report of a case. (21626334)
2011
15
Pleomorphic carcinoma of the lung with intrapulmonary aerogenic metastases on FDG PET. (20706051)
2010
16
Pulmonary pleomorphic carcinoma: a clinicopathological study including EGFR mutation analysis. (20107421)
2010
17
Pulmonary pleomorphic carcinoma: diagnosis using small biopsy specimens. (20736811)
2010
18
Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia. (21165299)
2010
19
Genetic heterogeneity of EGFR mutation in pleomorphic carcinoma of the lung: response to gefitinib and clinical outcome. (19155283)
2009
20
The role of palliative chemotherapy for advanced pulmonary pleomorphic carcinoma. (18989796)
2009
21
Esophageal polypoidal mass: presentation of an uncommon pleomorphic carcinoma. (19750865)
2009
22
Pleomorphic carcinoma of the lung with uncommon initial manifestation of intestinal perforation]. (19601528)
2009
23
Pleomorphic carcinoma with osteoclastic giant cells of the breast: immunohistochemical differentiation between coexisting neoplastic and reactive giant cells. (19154262)
2009
24
Pleomorphic carcinoma of the lung in which the sarcomatous element grew rapidly: a case report. (19471225)
2009
25
Two cases of pleomorphic carcinoma with severe systemic inflammation]. (19764522)
2009
26
Pleomorphic carcinoma of the lung: clinicopathologic characteristics of 70 cases. (18769330)
2008
27
Pleomorphic carcinoma of the lung expressing podoplanin and calretinin. (19067851)
2008
28
F-18 FDG PET imaging in a patient with granulocyte colony stimulating factor producing pulmonary pleomorphic carcinoma. (18645378)
2008
29
Long-term survival in two cases of resected gastric metastasis of pulmonary pleomorphic carcinoma. (18594328)
2008
30
Pleomorphic carcinoma of the lung: a report of six cases. (17978928)
2007
31
Expression of caveolin-1 in pleomorphic carcinoma of the lung is correlated with a poor prognosis. (16334154)
2005
32
Pleomorphic carcinoma of the lung associated with loss of heterozygosity of p53 gene. (15888975)
2005
33
Personal experience in surgical management of pulmonary pleomorphic carcinoma. (15511465)
2004
34
Metastatic pleomorphic carcinoma of lung presenting as abdominal pain. (15622698)
2004
35
Pleomorphic carcinoma of lung: comparison of CT features and pathologic findings. (15215543)
2004
36
Resection of a pleomorphic carcinoma of the lung invading the descending aorta. (15173751)
2004
37
Pleomorphic carcinomas of the lung show a selective distribution of gene products involved in cell differentiation, cell cycle control, tumor growth, and tumor cell motility: a clinicopathologic and immunohistochemical study of 31 cases. (12960804)
2003
38
Pleomorphic carcinoma of the breast: clinicopathological analysis of 26 cases of an unusual high-grade phenotype of ductal carcinoma. (10849092)
2000
39
Pathological study of the pleomorphic carcinoma of the lung]. (11866944)
2000
40
A case of pleomorphic carcinoma of the pancreas showing sequential histological change by immunohistochemical study. (7594772)
1995
41
Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells. (8113629)
1993
42
Pleomorphic carcinoma of the gallbladder: report of a case. (1803718)
1991
43
Surgical treatment of pleomorphic carcinoma of the pancreas. (2190511)
1990
44
Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells expressing an epithelial-associated antigen detected by monoclonal antibody 44-3A6. (3254809)
1988
45
Pleomorphic carcinoma of the pancreas: computed-tomographic, sonographic, and pathologic findings. (3880902)
1985
46
Pleomorphic carcinoma of the gallbladder: case report and ultrastructural study. (6539521)
1984
47
Pleomorphic carcinoma of the thyroid. (20312831)
1977
48
A functioning pleomorphic carcinoma of the thyroid. (1277059)
1976
49
Pleomorphic carcinoma of the larynx. (5643249)
1968
50
FOUR SEPARATE TUMOUR CLONES DERIVED FROM A TRANSPLANTABLE PLEOMORPHIC CARCINOMA OF THE LUNG IN A HETEROZYGOUS MOUSE. (14263471)
1965

Variations for Pleomorphic Carcinoma

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Expression for genes affiliated with Pleomorphic Carcinoma

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Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for genes affiliated with Pleomorphic Carcinoma

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GO Terms for genes affiliated with Pleomorphic Carcinoma

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Cellular components related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056346.4EGFR, KRT14, KRT8, NKX2-1, PDGFRA, PGR

Biological processes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex cell migrationGO:002179510.4EGFR, NKX2-1
2positive regulation of DNA replicationGO:00457409.8EGFR, PDGFRA
3Ras protein signal transductionGO:00072659.2EGFR, PDGFRA, TP53
4cellular response to amino acid stimulusGO:00712309.0EGFR, ZEB1
5positive regulation of transcription from RNA polymerase II promoterGO:00459447.9EGFR, NKX2-1, PGR, TP53, ZEB1

Molecular functions related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:00047149.7EGFR, PDGFRA
2enzyme bindingGO:00198998.7EGFR, NKX2-1, PGR, TP53

Sources for Pleomorphic Carcinoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet