MCID: PLM016
MIFTS: 52

Pleomorphic Carcinoma malady

Cancer diseases category

Summaries for Pleomorphic Carcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards: Pleomorphic Carcinoma is related to spindle cell carcinoma and mediastinitis. An important gene associated with Pleomorphic Carcinoma is KRT14 (keratin 14), and among its related pathways are EGFR Signaling Pathway and Akt Signaling Pathway . The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and salivary gland, and related mouse phenotypes are muscle and tumorigenesis.

Aliases & Classifications for Pleomorphic Carcinoma

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

pleomorphic carcinoma 8 60


External Ids:

Disease Ontology8 DOID:5662
SNOMED-CT56 16741004
NCIt39 C4094

Related Diseases for Pleomorphic Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1spindle cell carcinoma30.4MUC1, DES, VIM
2mediastinitis29.9CRP
3large cell carcinoma29.9NKX2-1, IVL, CGB5, EGFR
4bladder carcinoma29.9TP53, KRT8, KRT18, CAV1
5adenocarcinoma29.8TP53, GGT1, KRT8, KRT14, KRT18, FSCN1
6intussusception10.2
7thyroiditis10.1
8cerebral primitive neuroectodermal tumor10.0CD99
9keratosis10.0IVL
10epidermolysis bullosa10.0KRT14
11lichen planus10.0IVL
12pulmonary blastoma10.0NKX2-1
13dermatitis10.0IVL
14endometriosis10.0CALB2
15keratoacanthoma10.0IVL
16malignant peritoneal mesothelioma10.0CALB2
17histiocytosis10.0FSCN1
18graves' disease10.0NKX2-1
19cystadenocarcinoma10.0MUC1
20pheochromocytoma10.0CALB2
21molluscum contagiosum10.0IVL
22interstitial lung disease10.0MUC1
23pemphigus foliaceus10.0IVL
24hidradenoma10.0MUC1
25hepatoblastoma10.0KRT18
26sex cord-gonadal stromal tumor10.0CALB2
27infantile myofibromatosis10.0DES
28testicular cancer10.0CGB5
29hyperthyroidism10.0CGB5
30thymoma10.0NKX2-1, CALB2
31sarcoidosis10.0KRT8
32cryptorchidism10.0CGB5
33fibrous meningioma10.0MUC1
34hemangioma10.0NKX2-1, PDPN
35myoepithelioma10.0KRT14, VIM
36peritonitis10.0CRP
37pancreas disease10.0GGT1
38ischemia10.0CAV1
39primary hyperoxaluria10.0GGT1
40tonsillitis10.0CRP
41adenomatoid tumor10.0CALB2, VIM
42epithelial-myoepithelial carcinoma10.0KRT14
43dilated cardiomyopathy10.0DES
44cholesteatoma10.0KRT14, IVL
45syringoma10.0KRT14, MUC1
46eccrine porocarcinoma10.0MUC1
47meningitis10.0CRP
48arthritis10.0CRP
49neurofibroma10.0MUC1, VIM
50crohn's disease10.0CRP

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to pleomorphic carcinoma

Clinical Features for Pleomorphic Carcinoma

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Drugs & Therapeutics for Pleomorphic Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pleomorphic Carcinoma

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Carcinoma

Search NIH Clinical Center for Pleomorphic Carcinoma

Search CenterWatch for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

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Anatomical Context for Pleomorphic Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Pleomorphic Carcinoma:

32
Lung, Breast, Salivary gland, Pancreas, Thyroid, Prostate, Tongue, Smooth muscle, Small intestine, Colon, Liver, Ovary, Testes

Animal Models for Pleomorphic Carcinoma or affiliated genes

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36MGI
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Publications for Pleomorphic Carcinoma

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50PubMed
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Articles related to Pleomorphic Carcinoma:

(show top 50)    (show all 281)
idTitleAuthorsYear
1
Prognostic factors affecting the clinical outcome of carcinoma ex pleomorphic adenoma in the major salivary gland. (23924064)
2013
2
Carcinoma ex pleomorphic adenoma. Case report. (24027900)
2013
3
Small cell carcinoma ex-pleomorphic adenoma of the parotid gland. (22736150)
2012
4
Carcinoma ex pleomorphic adenoma of the maxillary sinus: a case report. (23288822)
2012
5
The expression of FHIT in salivary carcinoma ex pleomorphic adenoma. (22843886)
2012
6
Carcinoma ex pleomorphic adenoma of the upper lip. (22209228)
2012
7
Melanoma in a carcinoma ex pleomorphic adenoma of the parotid gland: a case report and putative histogenesis. (21411120)
2011
8
Carcinoma ex pleomorphic adenoma of the nasal cavity. (21505850)
2011
9
Biologic correlates of A^a8,F-FDG uptake on PET in pulmonary pleomorphic carcinoma. (20646779)
2011
10
Molecular profiles of EGFR, K-ras, c-met, and FGFR in pulmonary pleomorphic carcinoma, a rare lung malignancy. (21626008)
2011
11
Immunohistochemical expression of estrogens and progesterone receptors in carcinoma ex pleomorphic adenoma-undifferentiated and adenocarcinoma types. (20038908)
2010
12
Pulmonary pleomorphic carcinoma: diagnosis using small biopsy specimens. (20736811)
2010
13
Nonconventional papillary thyroid carcinomas with pleomorphic tumor giant cells: a diagnostic pitfall with anaplastic carcinoma. (20414675)
2010
14
Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia. (21165299)
2010
15
Pleomorphic lymphoepithelioma-like carcinoma of the urinary bladder. (19079656)
2009
16
Establishment and characterization of pleomorphic adenoma cell systems: an in-vitro demonstration of carcinomas arising secondarily from adenomas in the salivary gland. (19622142)
2009
17
Two cases of pleomorphic carcinoma with severe systemic inflammation]. (19764522)
2009
18
Laryngeal collision tumour: pleomorphic adenoma and squamous cell carcinoma. (19442350)
2009
19
A case report of metastasizing myoepithelial carcinoma of the parotid gland arising in a recurrent pleomorphic adenoma. (18650039)
2009
20
Expression patterns and prognostic significance of inhibitor of apoptosis proteins in adenoid cystic carcinoma and pleomorphic adenoma of lachrymal gland. (18955046)
2009
21
Adult jejunojejunal intussusception caused by metastasized pleomorphic carcinoma of the lung: report of a case. (19882322)
2009
22
Pleomorphic carcinoma of the lung: clinicopathologic characteristics of 70 cases. (18769330)
2008
23
Carcinoma ex pleomorphic adenoma of the minor salivary gland with pulmonary metastasis. (18306136)
2008
24
Intracapsular (in situ) carcinoma ex pleomorphic adenoma with unusual clinical and histological features. (18288478)
2008
25
Pleomorphic carcinoma of the lung: a report of six cases. (17978928)
2007
26
The spectrum of morphomolecular abnormalities of the E-cadherin/catenin complex in pleomorphic lobular carcinoma of the breast. (17721269)
2007
27
Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland. (17593077)
2007
28
Esophageal pleomorphic giant cell carcinoma combined with small cell carcinoma. (17610478)
2007
29
Intraductal carcinoma is the precursor of carcinoma ex pleomorphic adenoma and is often associated with dysfunctional p53. (17593217)
2007
30
Pleomorphic carcinoma of the lung: a surgical outcome. (17662779)
2007
31
Liver metastases of pancreatic acinar cell carcinoma with marked nuclear atypia and pleomorphism diagnosed by EUS FNA cytology: a case report with emphasis on FNA cytological findings. (17196112)
2006
32
Clear cell carcinoma arising from pleomorphic adenoma of a minor salivary gland: Report of a case with fine needle aspiration, histologic and immunohistochemical findings. (17152285)
2006
33
Pleomorphic lobular carcinoma in situ of the breast composed almost entirely of signet ring cells. (17040292)
2006
34
CNS metastases of carcinoma ex pleomorphic adenoma of the parotid gland. (16908563)
2006
35
Pleomorphic carcinoma of the lung with mediastinal extension following malignant lymphoma: report of a case. (16249854)
2005
36
Cyclooxygenase-2 regulates the degree of apoptosis by modulating bcl-2 protein in pleomorphic adenoma and mucoepidermoid carcinoma of the parotid gland. (15880952)
2005
37
Expression of CD99 in pleomorphic carcinomas of the lung. (15716602)
2005
38
Carcinoma ex benign pleomorphic adenoma of the parotid gland. (16217459)
2005
39
Metastatic pleomorphic carcinoma of lung presenting as abdominal pain. (15622698)
2004
40
Pleomorphic solid and cystic papillary carcinoma of the breast: two cases occurring in young women. (15185258)
2004
41
E-cadherin expression in pleomorphic lobular carcinoma: an aid to differentiation from ductal carcinoma. (12478484)
2002
42
Pleomorphic (giant and/or spindle cell) carcinoma of lung shows a high percentage of variant CYP1A12. (11468695)
2001
43
Epithelial-myoepithelial carcinoma arising in pleomorphic adenoma of the palate. (11027383)
2000
44
Mucoepidermoid carcinoma ex pleomorphic adenoma: nonspecific preoperative cytologic findings in six cases. (9723598)
1998
45
Deletion of the p16 gene and microsatellite instability in carcinoma arising in pleomorphic adenoma of the parotid gland. (9917133)
1998
46
Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells. (8113629)
1993
47
Pleomorphic carcinoma of the gallbladder: case report and ultrastructural study. (6539521)
1984
48
Polypoid spindle-cell carcinoma (pleomorphic carcinoma). Report of a case occurring on tongue and review of the literature. (787865)
1976
49
Unusual pleomorphic carcinoma of the pancreas featuring production of osteoid. (5252233)
1969
50
Total pancreatectomy for pleomorphic carcinoma. A five-year cure. (5902860)
1966

Genetic Variations for Pleomorphic Carcinoma

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Expression for genes affiliated with Pleomorphic Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleomorphic Carcinoma

Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for genes affiliated with Pleomorphic Carcinoma

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Sources:
55SinoBiological, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 4Cell Signaling Technology
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Compounds for genes affiliated with Pleomorphic Carcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1butyrate4410.5CALB2
2estrogen4410.2CALB2, IVL
3cycloheximide449.8CAV1, CGB5, KRT8
4forskolin44 49 1111.7VIM, IVL, NKX2-1, KRT18, KRT8
5dihydrotestosterone44 28 11 2412.6VIM, CGB5, DES, CDKN1B
6glycogen44 2410.5CGB5, CDKN1B, KRT18, KRT8
7mucicarmine449.5VIM, CALB2, DES, NKX2-1, MUC1, KRT14
8formaldehyde44 2410.5VIM, DES, NKX2-1, MUC1, CDKN1B, KRT18
9bromodeoxyuridine449.2VIM, IVL, DES, CDKN1B, KRT18, KRT14
10progestin449.2VIM, EGFR, CGB5, DES, MUC1
11agar449.2VIM, CAV1, EGFR, MUC1, CDKN1B, KRT18
12creatinine449.1GGT1, KRT18, CGB5, CRP
13retinoid449.1VIM, EGFR, IVL, KRT18, KRT14, KRT8
14b 723449.0VIM, CALB2, PDPN, DES, NKX2-1, MUC1
1512-o-tetradecanoylphorbol 13-acetate448.9IVL, DES, MUC1, CDKN1B, FSCN1, VIM
16gold448.9CAV1, PDPN, IVL, DES, MUC1, KRT18
17serine448.9CAV1, IVL, DES, NKX2-1, CDKN1B, FSCN1
18tamoxifen44 49 28 1111.8GGT1, KRT8, KRT14, CDKN1B, CGB5, EGFR
19dexamethasone44 49 28 1111.8CAV1, CGB5, NKX2-1, CDKN1B, KRT18, GGT1
20adriamycin448.8VIM, CSF3, DES, MUC1, KRT8, TP53
21gemcitabine44 49 1110.8CSF3, EGFR, MUC1, CDKN1B, TP53
22cytarabine44 49 1110.7VIM, CSF3, MUC1, CDKN1B, TP53
23actinomycin d448.7VIM, CGB5, DES, MUC1, CDKN1B, KRT18
24glucose448.7CAV1, CGB5, IVL, MUC1, CDKN1B, KRT18
25urea44 11 2410.7CGB5, IVL, KRT18, KRT14, KRT8, GGT1
26threonine448.6CAV1, DES, NKX2-1, MUC1, CDKN1B, FSCN1
27etoposide44 49 59 1111.6VIM, CAV1, CSF3, CGB5, CDKN1B, KRT8
28oligonucleotide448.6VIM, CAV1, IVL, NKX2-1, CDKN1B, KRT18
29steroid448.6CALB2, CAV1, CGB5, DES, NKX2-1, KRT18
30dmso448.5VIM, CSF3, CGB5, MUC1, CDKN1B, KRT18
31n acetylcysteine448.5CRP, EGFR, CDKN1B, KRT18, GGT1, TP53
325fluorouracil448.4CSF3, EGFR, IVL, MUC1, CDKN1B, KRT18
33cyclophosphamide44 49 1110.4CSF3, CRP, CGB5, CDKN1B, KRT18, TP53
34ethanol44 49 11 2411.3CALB2, CGB5, DES, MUC1, KRT18, KRT8
35iron44 249.3VIM, CAV1, CRP, IVL, DES, KRT18
36hematoxylin448.3VIM, CALB2, PDPN, IVL, DES, NKX2-1
37lactate448.2VIM, CRP, CGB5, IVL, DES, KRT18
38thymidine44 249.1CALB2, CSF3, IVL, DES, MUC1, CDKN1B
39paclitaxel44 49 119.8CALB2, CAV1, CSF3, EGFR, CGB5, CDKN1B
40methotrexate44 49 119.7VIM, CSF3, CRP, CGB5, IVL, MUC1
41arginine447.7VIM, CAV1, CGB5, DES, CDKN1B, KRT14
42lipid447.6VIM, CAV1, CRP, CGB5, IVL, MUC1
43doxorubicin44 49 119.6VIM, CAV1, CSF3, EGFR, CGB5, DES
44progesterone44 59 28 11 2411.5KRT18, KRT14, KRT8, TP53, CDKN1B, MUC1
45testosterone44 59 11 2410.3CALB2, VIM, CAV1, CRP, GGT1, KRT8
46cisplatin44 49 59 1110.3CAV1, CSF3, EGFR, CGB5, MUC1, CDKN1B
47retinoic acid44 247.3TP53, KRT8, VIM, CAV1, CSF3, EGFR
48vegf446.0VIM, CAV1, PDPN, CSF3, CRP, EGFR
49paraffin446.0TP53, VIM, CALB2, CAV1, PDPN, EGFR
50tyrosine446.0CGB5, EGFR, CSF3, PDPN, CAV1, CALB2

GO Terms for genes affiliated with Pleomorphic Carcinoma

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16Gene Ontology
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Cellular components related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.8KRT8, KRT14, KRT18
2intermediate filamentGO:0058829.4KRT8, KRT14, KRT18, DES, VIM
3filopodiumGO:0301759.3PDPN, CRP, FSCN1
4cytoplasmGO:0057377.3VIM, CALB2, EGFR, IVL, MUC1, CD99

Biological processes related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycle arrestGO:07185010.0TP53, CDKN1B
2response to ischemiaGO:0029319.9TP53, CAV1
3cerebral cortex cell migrationGO:0217959.7NKX2-1, EGFR
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.7MUC1, CDKN1B, TP53
5modulation by virus of host morphology or physiologyGO:0190489.3TP53, KRT8, KRT18, CAV1, VIM

Molecular functions related to Pleomorphic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.9KRT14, DES, VIM
2scaffold protein bindingGO:0971109.9KRT8, KRT18, VIM
3structural molecule activityGO:0051989.3CAV1, IVL, KRT18, KRT8
4enzyme bindingGO:0198998.5TP53, EGFR, CSF3, CAV1
5protein bindingGO:0055156.7NKX2-1, DES, EGFR, CRP, CAV1, VIM

Products for genes affiliated with Pleomorphic Carcinoma

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Sources for Pleomorphic Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet