PLS
MCID: PLM019
MIFTS: 48

Pleomorphic Liposarcoma (PLS) malady

Cancer diseases, Rare diseases categories

Summaries for Pleomorphic Liposarcoma

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34MalaCards
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MalaCards: Pleomorphic Liposarcoma, also known as liposarcoma, pleomorphic, is related to liposarcoma and fibrous histiocytoma, and has symptoms including early death/lethality, lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer and soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma. An important gene associated with Pleomorphic Liposarcoma is INHA (inhibin, alpha), and among its related pathways is Transcriptional misregulation in cancer. The compounds nad+ and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and bone, and related mouse phenotypes are reproductive system and hematopoietic system.

Aliases & Classifications for Pleomorphic Liposarcoma

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63UMLS, 9Disease Ontology, 50Orphanet, 46Novoseek, 59SNOMED-CT, 41NCIt, 36MeSH, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 50 
Rare tumors


Characteristics (Orphanet epidemiological data):

50
pleomorphic liposarcoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

pleomorphic liposarcoma 9 50
liposarcoma, pleomorphic 63
papillon-lefevre disease 63
liposarcoma pleomorphic 46
pls 50


External Ids:

Disease Ontology9 DOID:5702
NCIt41 C3705
MeSH36 D008080
ICD10 via Orphanet27 C49
SNOMED-CT via Orphanet60 112683004, 404071006
UMLS via Orphanet64 C0205825

Related Diseases for Pleomorphic Liposarcoma

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18GeneCards, 19GeneDecks
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Diseases related to Pleomorphic Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma31.4MDM2, CALB2, VIM, FUS
2fibrous histiocytoma30.4VIM, FUS
3sarcoma30.4FUS, VIM, CALB2, MDM2
4epithelioid sarcoma30.3CALB2, VIM
5fibroma30.3CALB2, VIM
6rhabdomyosarcoma30.1MDM2, CALB2, VIM, INHA
7adenocarcinoma30.1INHA, VIM, CALB2, MDM2
8melanoma30.1INHA, VIM, CALB2, MDM2
9lateral sclerosis10.4
10myocardial infarction10.4
11juvenile primary lateral sclerosis10.3
12liposarcoma of bone10.3
13histiocytoma10.3
14mediastinitis10.3
15dedifferentiated liposarcoma10.3
16lymphogranuloma venereum10.2
17encephalomyelitis10.2
18cardiogenic shock10.2
19neurofibromatosis10.1
20muir-torre syndrome10.1
21hepatitis10.1
22malignant mesenchymoma10.1
23mesenchymoma10.1
24osteosarcoma10.1
25pleomorphic rhabdomyosarcoma10.1
26prostate adenocarcinoma10.1
27prostatitis10.1
28thyroiditis10.1
29malignant peritoneal mesothelioma10.1CALB2
30coronary artery disease10.1
31acute myocardial infarction10.1
32artery disease10.1
33atherosclerosis10.1
34heart cancer10.1
35allergic encephalomyelitis10.1
36essential tremor10.1VIM
37giant cell glioblastoma10.1MDM2
38peripheral primitive neuroectodermal tumor10.1FUS
39sex cord-gonadal stromal tumor10.1INHA, CALB2
40sertoli-leydig cell tumor10.1INHA, CALB2
41adenofibroma10.1CALB2, INHA
42endometrial stromal sarcoma10.0VIM, INHA
43chordoma10.0INHA, VIM
44adenomatoid tumor10.0CALB2, VIM
45endometrial carcinoma10.0INHA, CALB2
46angiosarcoma10.0CALB2, VIM
47leydig cell tumor10.0INHA, CALB2
48adrenocortical carcinoma10.0CALB2, INHA
49adrenal adenoma10.0INHA, CALB2
50hemangiopericytoma10.0VIM, MDM2

Graphical network of the top 20 diseases related to Pleomorphic Liposarcoma:



Diseases related to pleomorphic liposarcoma

Symptoms for Pleomorphic Liposarcoma

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50Orphanet
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Symptoms:

50
  • early death/lethality
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • subcutaneous nodules/lipomas/tumefaction/swelling

Drugs & Therapeutics for Pleomorphic Liposarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Pleomorphic Liposarcoma

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Liposarcoma

Search NIH Clinical Center for Pleomorphic Liposarcoma

Search CenterWatch for Pleomorphic Liposarcoma

Genetic Tests for Pleomorphic Liposarcoma

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Anatomical Context for Pleomorphic Liposarcoma

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34MalaCards
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MalaCards organs/tissues related to Pleomorphic Liposarcoma:

34
Breast, Lung, Bone, Liver, Uterus, Thyroid, Pancreas, Prostate, Smooth muscle

Animal Models for Pleomorphic Liposarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pleomorphic Liposarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2MDM2, VIM, INHA, FUS
2MP:00053978.1FUS, INHA, VIM, MDM2
3MP:00053788.1MDM2, VIM, INHA, FUS
4MP:00053868.0MDM2, CALB2, VIM, FUS
5MP:00053878.0FUS, INHA, VIM, MDM2
6MP:00036317.7FUS, VIM, CALB2, MDM2

Publications for Pleomorphic Liposarcoma

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53PubMed
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Articles related to Pleomorphic Liposarcoma:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Immediate reconstruction of the chest wall by latissimus dorsi and vertical rectus abdominis musculocutaneous flaps after radical mastectomy for a huge pleomorphic liposarcoma. (23350740)
2013
2
p14(ARF) methylation is a common event in the pathogenesis and progression of myxoid and pleomorphic liposarcoma. (23918242)
2013
3
Pleomorphic liposarcoma: a clinicopathological, immunohistochemical and molecular cytogenetic study of 32 additional cases. (24274714)
2013
4
Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature. (23651098)
2013
5
Muir-Torre syndrome-associated pleomorphic liposarcoma arising in a previous radiation field. (23299928)
2013
6
Dedifferentiated liposarcoma and pleomorphic liposarcoma: A comparative study of cytomorphology and MDM2/CDK4 expression on fine-needle aspiration. (24227706)
2013
7
Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. (22472959)
2012
8
Primary pleomorphic liposarcoma of the orbit: a case report. (22551368)
2012
9
Pleomorphic liposarcoma: clinical observations and molecular variables. (21598240)
2011
10
Orbital pleomorphic liposarcoma in an eight-year-old boy. (21417910)
2011
11
Metachronous pleomorphic liposarcoma and melanoma: a rare case report. (21393919)
2011
12
Primary pleomorphic liposarcoma of breast: a rare case report. (21393893)
2011
13
Primary pleomorphic liposarcoma of bone in an adolescent: imaging features of a rare entity. (21573914)
2011
14
Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature. (20604797)
2010
15
Pleomorphic liposarcoma originating from intracranial dura mater. (19727564)
2010
16
Metastasis after resection of huge primary pericardial pleomorphic liposarcoma with cardiopulmonary bypass. (20333575)
2010
17
Epithelioid variant of a pleomorphic liposarcoma displaying arborizing vascular arrangements on cytology smears: a case report of an interesting cytomorphologic pattern in an uncommon tumor. (21053578)
2010
18
Radiological-pathological correlation of pleomorphic liposarcoma of the anterior mediastinum in a 17-year-old girl. (20827472)
2010
19
Pleomorphic liposarcoma of the axilla metastatic to the pancreas. (19590203)
2009
20
Analysis of CHOP rearrangement in pleomorphic liposarcomas using fluorescence in situ hybridization. (19037998)
2009
21
Pleomorphic liposarcoma of the pectoralis major muscle in an elderly man: report of a case and review of literature. (20160372)
2009
22
Pleomorphic liposarcoma of the foot: a case report. (18416844)
2008
23
Mediastinal pleomorphic liposarcoma diagnosed by fine needle aspiration biopsy: a case report. (17536551)
2007
24
Epithelioid variant of pleomorphic liposarcoma in a heifer. (17645889)
2007
25
Pathology quiz case 2. Pleomorphic liposarcoma (PLS) of the retrotonsillar fossa. (17372093)
2007
26
Primary pleomorphic liposarcoma of bone: MRI findings and review of the literature. (16175410)
2006
27
Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances. (15702084)
2005
28
Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript. (15720420)
2005
29
Pulmonary pleomorphic liposarcoma. (16164258)
2005
30
Primary pleomorphic liposarcoma of the parotid gland: a case report and review of the literature. (15547814)
2004
31
Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. (15371941)
2004
32
Focal divergent chondrosarcomatous differentiation in a primary pleomorphic liposarcoma and expression of transforming growth factor beta. (14765280)
2004
33
Pleomorphic liposarcoma in a ten year old child. (15552292)
2004
34
Epithelioid variant of pleomorphic liposarcoma: report of a case. (15462502)
2004
35
Pleomorphic liposarcoma of the uterus: case report and literature review. (14501826)
2003
36
Primary purely intradermal pleomorphic liposarcoma. (12950504)
2003
37
Pleomorphic liposarcoma metastatic to the thyroid gland. (11805476)
2002
38
Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma. (12036902)
2002
39
Pleomorphic liposarcoma. (11757868)
2001
40
Fine needle aspiration of pleomorphic liposarcoma of the breast: revised diagnosis. (11726108)
2001
41
Pleomorphic liposarcoma of a young woman following radiotherapy for epithelioid sarcoma. (11173662)
2000
42
Epithelioid variant of pleomorphic liposarcoma: a study of 12 cases of a distinctive variant of high-grade liposarcoma. (10430277)
1999
43
Mesenteric pleomorphic liposarcoma in an adolescent. (9126049)
1997
44
Pleomorphic liposarcoma of the pterygomandibular space involving the maxilla. (7614211)
1995
45
Ultrastructural characteristics of a pleomorphic liposarcoma. A possible involvement of myofibroblast. (3630699)
1987
46
Pleomorphic liposarcoma in an aged rat. (3712904)
1986
47
Case report 172: pleomorphic liposarcoma, grade IV, of the soft tissue, arising in generalized plexiform neurofibromatosis. (6800037)
1981
48
Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. (223963)
1979
49
Primary pleomorphic liposarcoma of the larynx. (650725)
1978
50
Ultrastructural observations in pleomorphic liposarcoma. (212174)
1978

Variations for Pleomorphic Liposarcoma

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Expression for genes affiliated with Pleomorphic Liposarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleomorphic Liposarcoma

Search GEO for disease gene expression data for Pleomorphic Liposarcoma.

Pathways for genes affiliated with Pleomorphic Liposarcoma

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51PathCards, 31KEGG
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Pathways related to Pleomorphic Liposarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MDM2, FUS

Compounds for genes affiliated with Pleomorphic Liposarcoma

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46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Pleomorphic Liposarcoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1nad+469.8MDM2, INHA
2mucicarmine469.5CALB2, VIM
3b 723469.5VIM, CALB2
4roscovitine469.5MDM2, VIM
5vinblastine46 52 1211.4MDM2, VIM
6gefitinib46 52 1211.4MDM2, VIM
7biotin46 25 1211.4INHA, VIM
8thymidylate469.3MDM2, VIM
9vincristine46 52 1211.3MDM2, VIM
10steroid469.3INHA, CALB2, MDM2
11adriamycin469.2MDM2, VIM
125-hydroxytryptamine469.2VIM, CALB2
13choline46 25 1211.1CALB2, VIM
14valine469.1MDM2, VIM
15zinc46 2510.1FUS, CALB2, MDM2
16hematoxylin469.1CALB2, VIM, INHA
17hyaluronic acid46 2510.0CALB2, VIM
18estradiol46 25 1211.0MDM2, VIM, INHA
19cyclic amp46 2510.0MDM2, VIM, INHA
20oligonucleotide469.0MDM2, VIM, INHA
21paclitaxel46 52 1211.0VIM, CALB2, MDM2
22alanine468.9MDM2, VIM, INHA
23glutamate468.8MDM2, CALB2, VIM
245-aza-2deoxycytidine468.8MDM2, VIM
25paraffin468.5MDM2, CALB2, VIM, INHA
26progesterone46 30 62 25 1212.5INHA, VIM, CALB2, MDM2
27testosterone46 62 25 1211.5MDM2, CALB2, VIM, INHA
28estrogen468.5INHA, VIM, CALB2, MDM2

GO Terms for genes affiliated with Pleomorphic Liposarcoma

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17Gene Ontology
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Molecular functions related to Pleomorphic Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971108.8MDM2, VIM
2identical protein bindingGO:0428028.5MDM2, VIM, FUS

Products for genes affiliated with Pleomorphic Liposarcoma

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Sources for Pleomorphic Liposarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet