MCID: PLM019
MIFTS: 42

Pleomorphic Liposarcoma malady

Cancer diseases, Rare diseases categories

Summaries for Pleomorphic Liposarcoma

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MalaCards based summary: Pleomorphic Liposarcoma, also known as liposarcoma, pleomorphic, is related to liposarcoma and fibrous histiocytoma, and has symptoms including abnormality of the skin, sarcoma and neoplasm of the lung. An important gene associated with Pleomorphic Liposarcoma is INHA (inhibin, alpha), and among its related pathways is Transcriptional misregulation in cancer. The compounds nad+ and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and skin, and related mouse phenotypes are reproductive system and hematopoietic system.

Aliases & Classifications for Pleomorphic Liposarcoma

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Sources:
9Disease Ontology, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Pleomorphic Liposarcoma, Aliases & Descriptions:

Name: Pleomorphic Liposarcoma 9 47
Liposarcoma, Pleomorphic 60
Papillon-Lefevre Disease 60
 
Liposarcoma Pleomorphic 43
Pls 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 47 
Rare tumors


Characteristics (Orphanet epidemiological data):

47
pleomorphic liposarcoma:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adult; Age of death: adult


External Ids:

Disease Ontology9 DOID:5702
MeSH33 D008080
NCIt38 C3705
Orphanet47 99969
ICD10 via Orphanet26 C49
UMLS via Orphanet61 C0205825

Related Diseases for Pleomorphic Liposarcoma

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Diseases related to Pleomorphic Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma31.0FUS, MDM2, CALB2, VIM
2fibrous histiocytoma30.5FUS, VIM
3epithelioid sarcoma30.5VIM, CALB2
4fibroma30.5VIM, CALB2
5rhabdomyosarcoma30.1CALB2, VIM, INHA, MDM2
6sarcoma29.9FUS, CALB2, MDM2, VIM
7adenocarcinoma29.8INHA, MDM2, VIM, CALB2
8melanoma29.8MDM2, CALB2, VIM, INHA
9myocardial infarction10.4
10malignant peritoneal mesothelioma10.4CALB2
11essential tremor10.4VIM
12primary lateral sclerosis, juvenile10.4
13lateral sclerosis10.4
14giant cell glioblastoma10.3MDM2
15liposarcoma of bone10.3
16histiocytoma10.3
17mediastinitis10.3
18dedifferentiated liposarcoma10.3
19peripheral primitive neuroectodermal tumor10.3FUS
20primary lateral sclerosis, adult, 110.3
21sex cord-gonadal stromal tumor10.2INHA, CALB2
22sertoli-leydig cell tumor10.2CALB2, INHA
23adenofibroma10.2CALB2, INHA
24endometrial stromal sarcoma10.2INHA, VIM
25acute myocardial infarction10.2
26lymphogranuloma venereum10.2
27cardiogenic shock10.2
28chordoma10.2VIM, INHA
29adenomatoid tumor10.2CALB2, VIM
30endometrial cancer10.2CALB2, INHA
31angiosarcoma10.2CALB2, VIM
32muir-torre syndrome10.2
33hepatitis10.2
34neurofibromatosis10.2
35malignant mesenchymoma10.2
36mesenchymoma10.2
37ovarian carcinosarcoma10.2
38pleomorphic rhabdomyosarcoma10.2
39prostate adenocarcinoma10.2
40prostatitis10.2
41thyroiditis10.2
42leydig cell tumor10.2INHA, CALB2
43adrenocortical carcinoma10.1INHA, CALB2
44adrenal cortical adenoma10.1INHA, CALB2
45hemangiopericytoma10.1VIM, MDM2
46papillon-lefevre syndrome10.1
47coronary artery disease10.1
48atherosclerosis10.1
49artery disease10.1
50heart cancer10.1

Graphical network of the top 20 diseases related to Pleomorphic Liposarcoma:



Diseases related to pleomorphic liposarcoma

Symptoms for Pleomorphic Liposarcoma

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Symptoms:

 47
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • early death/lethality

HPO human phenotypes related to Pleomorphic Liposarcoma:

id Description Frequency HPO Source Accession
1 abnormality of the skin hallmark (90%) HP:0000951
2 sarcoma hallmark (90%) HP:0100242
3 neoplasm of the lung occasional (7.5%) HP:0100526

Drugs & Therapeutics for Pleomorphic Liposarcoma

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Drug clinical trials:

Search ClinicalTrials for Pleomorphic Liposarcoma

Search NIH Clinical Center for Pleomorphic Liposarcoma

Genetic Tests for Pleomorphic Liposarcoma

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Anatomical Context for Pleomorphic Liposarcoma

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MalaCards organs/tissues related to Pleomorphic Liposarcoma:

31
Lung, Breast, Skin, Bone, Liver, Smooth muscle, Pancreas, Thyroid, Uterus, Prostate

Animal Models for Pleomorphic Liposarcoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Liposarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2MDM2, VIM, INHA, FUS
2MP:00053978.1FUS, INHA, VIM, MDM2
3MP:00053788.1MDM2, VIM, INHA, FUS
4MP:00053868.0MDM2, CALB2, VIM, FUS
5MP:00053878.0FUS, INHA, VIM, MDM2
6MP:00036317.7FUS, VIM, CALB2, MDM2

Publications for Pleomorphic Liposarcoma

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Articles related to Pleomorphic Liposarcoma:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Small bowel pleomorphic liposarcoma: a rare cause of gastrointestinal bleeding. (25161780)
2014
2
Rhabdomyosarcoma with pseudolipoblasts arising in ovarian carcinosarcoma: a distinctive postchemotherapy morphologic variant mimicking pleomorphic liposarcoma. (24587930)
2014
3
Pleomorphic liposarcoma: A cytologic study of five cases. (24652822)
2014
4
Immediate reconstruction of the chest wall by latissimus dorsi and vertical rectus abdominis musculocutaneous flaps after radical mastectomy for a huge pleomorphic liposarcoma. (23350740)
2013
5
p14(ARF) methylation is a common event in the pathogenesis and progression of myxoid and pleomorphic liposarcoma. (23918242)
2013
6
Pleomorphic liposarcoma: a clinicopathological, immunohistochemical and molecular cytogenetic study of 32 additional cases. (24274714)
2013
7
Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature. (23651098)
2013
8
Muir-Torre syndrome-associated pleomorphic liposarcoma arising in a previous radiation field. (23299928)
2013
9
Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. (22472959)
2012
10
Primary pleomorphic liposarcoma of the orbit: a case report. (22551368)
2012
11
Pleomorphic liposarcoma: clinical observations and molecular variables. (21598240)
2011
12
Orbital pleomorphic liposarcoma in an eight-year-old boy. (21417910)
2011
13
Metachronous pleomorphic liposarcoma and melanoma: a rare case report. (21393919)
2011
14
Primary pleomorphic liposarcoma of breast: a rare case report. (21393893)
2011
15
Primary pleomorphic liposarcoma of bone in an adolescent: imaging features of a rare entity. (21573914)
2011
16
Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature. (20604797)
2010
17
Pleomorphic liposarcoma originating from intracranial dura mater. (19727564)
2010
18
Metastasis after resection of huge primary pericardial pleomorphic liposarcoma with cardiopulmonary bypass. (20333575)
2010
19
Epithelioid variant of a pleomorphic liposarcoma displaying arborizing vascular arrangements on cytology smears: a case report of an interesting cytomorphologic pattern in an uncommon tumor. (21053578)
2010
20
Radiological-pathological correlation of pleomorphic liposarcoma of the anterior mediastinum in a 17-year-old girl. (20827472)
2010
21
Pleomorphic liposarcoma of the axilla metastatic to the pancreas. (19590203)
2009
22
Analysis of CHOP rearrangement in pleomorphic liposarcomas using fluorescence in situ hybridization. (19037998)
2009
23
Pleomorphic liposarcoma of the foot: a case report. (18416844)
2008
24
Mediastinal pleomorphic liposarcoma diagnosed by fine needle aspiration biopsy: a case report. (17536551)
2007
25
Epithelioid variant of pleomorphic liposarcoma in a heifer. (17645889)
2007
26
Pathology quiz case 2. Pleomorphic liposarcoma (PLS) of the retrotonsillar fossa. (17372093)
2007
27
Primary pleomorphic liposarcoma of bone: MRI findings and review of the literature. (16175410)
2006
28
Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances. (15702084)
2005
29
Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript. (15720420)
2005
30
Pulmonary pleomorphic liposarcoma. (16164258)
2005
31
Primary pleomorphic liposarcoma of the parotid gland: a case report and review of the literature. (15547814)
2004
32
Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. (15371941)
2004
33
Focal divergent chondrosarcomatous differentiation in a primary pleomorphic liposarcoma and expression of transforming growth factor beta. (14765280)
2004
34
Pleomorphic liposarcoma in a ten year old child. (15552292)
2004
35
Pleomorphic liposarcoma of the uterus: case report and literature review. (14501826)
2003
36
Primary purely intradermal pleomorphic liposarcoma. (12950504)
2003
37
Pleomorphic liposarcoma metastatic to the thyroid gland. (11805476)
2002
38
Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma. (12036902)
2002
39
Pleomorphic liposarcoma. (11757868)
2001
40
Fine needle aspiration of pleomorphic liposarcoma of the breast: revised diagnosis. (11726108)
2001
41
Pleomorphic liposarcoma of a young woman following radiotherapy for epithelioid sarcoma. (11173662)
2000
42
Epithelioid variant of pleomorphic liposarcoma: a study of 12 cases of a distinctive variant of high-grade liposarcoma. (10430277)
1999
43
Mesenteric pleomorphic liposarcoma in an adolescent. (9126049)
1997
44
Pleomorphic liposarcoma of the pterygomandibular space involving the maxilla. (7614211)
1995
45
Ultrastructural characteristics of a pleomorphic liposarcoma. A possible involvement of myofibroblast. (3630699)
1987
46
Pleomorphic liposarcoma in an aged rat. (3712904)
1986
47
Case report 172: pleomorphic liposarcoma, grade IV, of the soft tissue, arising in generalized plexiform neurofibromatosis. (6800037)
1981
48
Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. (223963)
1979
49
Primary pleomorphic liposarcoma of the larynx. (650725)
1978
50
Ultrastructural observations in pleomorphic liposarcoma. (212174)
1978

Variations for Pleomorphic Liposarcoma

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Expression for genes affiliated with Pleomorphic Liposarcoma

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Search GEO for disease gene expression data for Pleomorphic Liposarcoma.

Pathways for genes affiliated with Pleomorphic Liposarcoma

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Pathways related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MDM2, FUS

Compounds for genes affiliated with Pleomorphic Liposarcoma

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Compounds related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

(show all 28)
idCompoundScoreTop Affiliating Genes
1nad+439.8MDM2, INHA
2mucicarmine439.5CALB2, VIM
3b 723439.5VIM, CALB2
4roscovitine439.5MDM2, VIM
5vinblastine43 49 1211.4MDM2, VIM
6gefitinib43 49 1211.4MDM2, VIM
7biotin43 24 1211.4INHA, VIM
8thymidylate439.3MDM2, VIM
9vincristine43 49 1211.3MDM2, VIM
10steroid439.3INHA, CALB2, MDM2
11adriamycin439.2MDM2, VIM
125-hydroxytryptamine439.2VIM, CALB2
13choline43 24 1211.1CALB2, VIM
14valine439.1MDM2, VIM
15zinc43 2410.1FUS, CALB2, MDM2
16hematoxylin439.1CALB2, VIM, INHA
17hyaluronic acid43 2410.0CALB2, VIM
18estradiol43 24 1211.0MDM2, VIM, INHA
19cyclic amp43 2410.0MDM2, VIM, INHA
20oligonucleotide439.0MDM2, VIM, INHA
21paclitaxel43 49 1211.0VIM, CALB2, MDM2
22alanine438.9MDM2, VIM, INHA
23glutamate438.8MDM2, CALB2, VIM
245-aza-2deoxycytidine438.8MDM2, VIM
25paraffin438.5MDM2, CALB2, VIM, INHA
26progesterone43 28 59 24 1212.5INHA, VIM, CALB2, MDM2
27testosterone43 59 24 1211.5MDM2, CALB2, VIM, INHA
28estrogen438.5INHA, VIM, CALB2, MDM2

GO Terms for genes affiliated with Pleomorphic Liposarcoma

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Molecular functions related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:00971108.8MDM2, VIM
2identical protein bindingGO:00428028.5MDM2, VIM, FUS

Products for genes affiliated with Pleomorphic Liposarcoma

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Sources for Pleomorphic Liposarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet