MCID: PLM019
MIFTS: 42

Pleomorphic Liposarcoma

Categories: Rare diseases, Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pleomorphic Liposarcoma

MalaCards integrated aliases for Pleomorphic Liposarcoma:

Name: Pleomorphic Liposarcoma 12 56 14
Liposarcoma, Pleomorphic 69
Liposarcoma Pleomorphic 52
Pls 56

Characteristics:

Orphanet epidemiological data:

56
pleomorphic liposarcoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:5702
MeSH 42 D008080
NCIt 47 C3705
SNOMED-CT 64 112683004 404071006
Orphanet 56 ORPHA99969
UMLS via Orphanet 70 C0205825
ICD10 via Orphanet 34 C49.9
SNOMED-CT via HPO 65 95325000
UMLS 69 C0205825

Summaries for Pleomorphic Liposarcoma

MalaCards based summary : Pleomorphic Liposarcoma, also known as liposarcoma, pleomorphic, is related to dedifferentiated liposarcoma and mesenchymoma, and has symptoms including subcutaneous nodule An important gene associated with Pleomorphic Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Dacarbazine and Epirubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and breast, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Pleomorphic Liposarcoma

Diseases related to Pleomorphic Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
id Related Disease Score Top Affiliating Genes
1 dedifferentiated liposarcoma 30.5 MUC1 S100B
2 mesenchymoma 30.1 MUC1 VIM
3 epithelioid sarcoma 30.0 INHA MUC1
4 histiocytoma 28.4 ACTC1 DES INHA VIM
5 lateral sclerosis 11.7
6 primary lateral sclerosis, juvenile 11.6
7 primary lateral sclerosis, adult, 1 11.6
8 pityriasis lichenoides 11.1
9 papillon-lefevre syndrome 10.9
10 pancreatic lipase deficiency 10.8
11 motor neuron disease 10.8
12 proteus-like syndrome 10.8
13 epidural neoplasm 10.7 CDKN2A MDM2
14 liposarcoma 10.7
15 rectum squamous cell carcinoma 10.7 CDKN2A MDM2
16 juxtacortical chondrosarcoma 10.7 CDKN2A MDM2
17 rhabditida infections 10.6 MDM2 VIM
18 bladder squamous cell carcinoma 10.6 CDKN2A MDM2
19 immune-mediated encephalomyelitis 10.6 S100B VIM
20 amelogenesis imperfecta local hypoplastic 10.6 CDKN2A VIM
21 benallegue lacete syndrome 10.6 S100B VIM
22 neurogenic thoracic outlet syndrome 10.6 S100B VIM
23 adult liposarcoma 10.6 CDKN2A MDM2
24 nasal cavity lymphoma 10.5 CDKN2A KRT8
25 malignant breast melanoma 10.5 S100B VIM
26 2q31.1 microdeletion syndrome 10.5 MUC1 VIM
27 oligomeganephronic renal hypoplasia 10.5 S100B VIM
28 logopenic progressive aphasia 10.5 MUC1 S100B
29 heiner syndrome 10.5 MUC1 S100B
30 colon squamous cell carcinoma 10.5 CDKN2A KRT8
31 chronic neutrophilic leukemia 10.5 CDKN2A MUC1
32 meningitis and encephalitis 10.5 MUC1 S100B
33 extraosseous osteosarcoma 10.5 CDKN2A MDM2
34 pediatric ependymoma 10.5 KRT8 S100B
35 pulmonary type ovarian small cell carcinoma 10.5 CDKN2A MUC1
36 simple cryoglobulinemia 10.5 MUC1 S100B
37 enteric pattern testicular yolk sac tumor 10.5 MUC1 S100B
38 olivopontocerebellar atrophy deafness 10.5 KRT8 VIM
39 middle ear squamous cell carcinoma 10.5 CDKN2A KRT8
40 hip subluxation 10.5 S100B VIM
41 gastric papillary adenocarcinoma 10.5 MUC1 S100B
42 pleural empyema 10.4 MUC1 S100B
43 aflatoxins-related hepatocellular carcinoma 10.4 KRT8 VIM
44 vulvar angiokeratoma 10.4 MUC1 VIM
45 pyoderma 10.4 MUC1 VIM
46 differentiating neuroblastoma 10.4 KRT8 S100B
47 advanced sleep phase syndrome 10.4 CDKN2A MUC1
48 leiomyoma cutis 10.4 ACTC1 CDKN2A
49 ovary papillary carcinoma 10.4 MUC1 VIM
50 pancreatic serous cystadenoma 10.4 MUC1 VIM

Graphical network of the top 20 diseases related to Pleomorphic Liposarcoma:



Diseases related to Pleomorphic Liposarcoma

Symptoms & Phenotypes for Pleomorphic Liposarcoma

Human phenotypes related to Pleomorphic Liposarcoma:

56 32
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 56 32 hallmark (90%) Very frequent (99-80%) HP:0001482

MGI Mouse Phenotypes related to Pleomorphic Liposarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 ACTC1 CDKN2A DES INHA KRT8 MDM2
2 homeostasis/metabolism MP:0005376 9.56 ACTC1 CDKN2A DES INHA KRT8 MDM2
3 muscle MP:0005369 9.02 CDKN2A DES MDM2 VIM ACTC1

Drugs & Therapeutics for Pleomorphic Liposarcoma

Drugs for Pleomorphic Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 3 4342-03-4 5351166
2
Epirubicin Approved Phase 3 56420-45-2 41867
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Gemcitabine Approved Phase 3 95058-81-4 60750
5
Ifosfamide Approved Phase 3 3778-73-2 3690
6
Mechlorethamine Approved Phase 3 51-75-2 4033
7
Trabectedin Approved, Investigational Phase 3 114899-77-3 108150
8
Docetaxel Approved May 1996, Investigational Phase 3 114977-28-5 148124 9877265
9 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2
10 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2
11 Topoisomerase Inhibitors Phase 3,Phase 1
12 Alkylating Agents Phase 3
13 Anti-Infective Agents Phase 3,Phase 1,Phase 2
14 Antimetabolites Phase 3
15 Antimetabolites, Antineoplastic Phase 3
16 Antimitotic Agents Phase 3
17 Antineoplastic Agents, Phytogenic Phase 3
18 Antiviral Agents Phase 3
19 Etoposide phosphate Phase 3
20 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
21 Isophosphamide mustard Phase 3
22
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
23
nivolumab Approved Phase 2,Phase 1 946414-94-4
24
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
25
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
26
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
27
Pembrolizumab Approved Phase 2 1374853-91-4
28
Maleic acid Experimental Phase 2 110-16-7 444266
29 Hypoglycemic Agents Phase 2
30 Antibodies Phase 2,Phase 1
31 Antibodies, Monoclonal Phase 2,Phase 1
32 Immunoglobulins Phase 2,Phase 1
33 Antifungal Agents Phase 1, Phase 2
34
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
35
Doxil Approved June 1999 Phase 1 31703

Interventional clinical trials:

(show all 12)

id Name Status NCT ID Phase Drugs
1 Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy Recruiting NCT01710176 Phase 3 epirubicin 60 mg/m2/day (days 1, 2) and ifosfamide 3 g/m2/day (days 1, 2, 3);gemcitabine 900 mg/m2 (days 1 and 8) and docetaxel 75 mg/m2 (day 8);trabectedin 1.3 mg/m2;high-dose ifosfamide 14 g/m2, given in in 14 days;etoposide 150 mg/m2/day (days 1, 2, 3) and ifosfamide 3g/m2/day (days 1, 2, 3);gemcitabine 1800 mg/m2 (day 1) and dacarbazine 500 mg/m2 (day 1)
2 Rosiglitazone in Treating Patients With Liposarcoma Completed NCT00004180 Phase 2 rosiglitazone maleate
3 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
4 Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery Recruiting NCT02500797 Phase 2
5 Study of Neoadjuvant Checkpoint Blockade in Patients With Surgically Resectable Undifferentiated Pleomorphic Sarcoma and Dedifferentiated Liposarcoma Recruiting NCT03307616 Phase 2 Nivolumab;Ipilimumab
6 Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma Recruiting NCT03190174 Phase 1, Phase 2 Nab-Rapamycin
7 SARC028: A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas Recruiting NCT02301039 Phase 2 Pembrolizumab
8 Activity and Tolerability of Pazopanib in Advanced and/or Metastatic Liposarcoma. A Phase II Clinical Trial Active, not recruiting NCT01692496 Phase 2 Pazopanib
9 Efficacy and Safety of Plitidepsin in Patients With Advanced Unresectable or Metastatic, Relapsed/Refractory, Dedifferentiated Liposarcoma (DLPS): an Exploratory Phase II Multicenter Trial Terminated NCT01876043 Phase 2 plitidepsin
10 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
11 Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery Recruiting NCT03009201 Phase 1 Doxorubicin;Ribociclib
12 Detection of Circulating Tumor Cells in Patients With Sarcomas Recruiting NCT02983539

Search NIH Clinical Center for Pleomorphic Liposarcoma

Genetic Tests for Pleomorphic Liposarcoma

Anatomical Context for Pleomorphic Liposarcoma

MalaCards organs/tissues related to Pleomorphic Liposarcoma:

39
Bone, Liver, Breast, Uterus, Prostate, Cervix, Ovary

Publications for Pleomorphic Liposarcoma

Articles related to Pleomorphic Liposarcoma:

(show top 50) (show all 87)
id Title Authors Year
1
A huge primary pleomorphic liposarcoma of the left atrium. ( 28747948 )
2017
2
Pleomorphic liposarcoma of the head and neck: Presentation of two cases and literature review. ( 28528729 )
2017
3
Effective apatinib treatment of pleomorphic liposarcoma: A case report. ( 28816958 )
2017
4
Association of Li-Fraumeni Syndrome With Small Cell Carcinoma of the Ovary, Hypercalcemic Type and Concurrent Pleomorphic Liposarcoma of the Cervix. ( 28177947 )
2017
5
Primary dermal pleomorphic liposarcoma: utility of adipophilin and MDM2/CDK4 immunostainings. ( 27778364 )
2016
6
Cutaneous metastasis of pleomorphic liposarcoma to the scalp: an elusive diagnosis. ( 26968423 )
2016
7
Primary pleomorphic liposarcoma of the spine. Case report and review of the literature. ( 27351623 )
2016
8
Cellular Angiofibroma With Sarcomatous Transformation Showing Pleomorphic Liposarcoma-Like and Atypical Lipomatous Tumor-Like Features. ( 26760687 )
2016
9
Pleomorphic Liposarcoma Arising in a Lipoleiomyosarcoma of the Uterus: Report of a Case With Genetic Profiling by a Next Generation Sequencing Panel. ( 26598981 )
2015
10
Primary pleomorphic liposarcoma of the thoracic epidural space: case report. ( 26343245 )
2015
11
Pleomorphic liposarcoma arising in a malignant phyllodes tumor of breast: A rare occurrence. ( 26881623 )
2015
12
Pleomorphic liposarcoma of the inferior vena cava. ( 25590403 )
2015
13
Primary mediastinal pleomorphic liposarcoma involving the superior vena cava. ( 26767011 )
2014
14
Pleomorphic liposarcoma: A cytologic study of five cases. ( 24652822 )
2014
15
Rhabdomyosarcoma with pseudolipoblasts arising in ovarian carcinosarcoma: a distinctive postchemotherapy morphologic variant mimicking pleomorphic liposarcoma. ( 24587930 )
2014
16
Small bowel pleomorphic liposarcoma: a rare cause of gastrointestinal bleeding. ( 25161780 )
2014
17
Pleomorphic liposarcoma of the hand. ( 24870378 )
2014
18
The surgical management of a giant pleomorphic liposarcoma of the chest wall. ( 25392049 )
2014
19
Primary pleomorphic liposarcoma of liver: a case report and review of the literature. ( 25374715 )
2013
20
Dedifferentiated liposarcoma and pleomorphic liposarcoma: A comparative study of cytomorphology and MDM2/CDK4 expression on fine-needle aspiration. ( 24227706 )
2013
21
Immediate reconstruction of the chest wall by latissimus dorsi and vertical rectus abdominis musculocutaneous flaps after radical mastectomy for a huge pleomorphic liposarcoma. ( 23350740 )
2013
22
Liver Metastasis of Extremity Pleomorphic Liposarcoma Treated with Hepatic Resection. ( 23959373 )
2013
23
p14(ARF) methylation is a common event in the pathogenesis and progression of myxoid and pleomorphic liposarcoma. ( 23918242 )
2013
24
Muir-Torre syndrome-associated pleomorphic liposarcoma arising in a previous radiation field. ( 23299928 )
2013
25
Pleomorphic liposarcoma: a clinicopathological, immunohistochemical and molecular cytogenetic study of 32 additional cases. ( 24274714 )
2013
26
Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature. ( 23651098 )
2013
27
Combined cutaneous sarcoma: pleomorphic liposarcoma and conventional osteosarcoma-the so-called malignant mesenchymoma. ( 23082265 )
2012
28
Earlier detection of bone metastases from pleomorphic liposarcoma in a pediatric patient by FDG PET/CT than planar 99mTc MDP bone scan. ( 22475918 )
2012
29
Primary pleomorphic liposarcoma of the orbit: a case report. ( 22551368 )
2012
30
Primary orbital pleomorphic liposarcoma: an aggressive course. ( 22460675 )
2012
31
Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. ( 22472959 )
2012
32
Orbital pleomorphic liposarcoma in an eight-year-old boy. ( 21417910 )
2011
33
Prostatic adenocarcinoma metastatic to pleomorphic liposarcoma, a "collision phenomenon": report of a case with review of pelvic collision tumors. ( 21904691 )
2011
34
Primary pleomorphic liposarcoma of breast: a rare case report. ( 21393893 )
2011
35
Pleomorphic liposarcoma: clinical observations and molecular variables. ( 21598240 )
2011
36
Pleomorphic liposarcoma of the uterine corpus with focal smooth muscle differentiation. ( 21464725 )
2011
37
Primary pleomorphic liposarcoma of bone in an adolescent: imaging features of a rare entity. ( 21573914 )
2011
38
Epithelioid variant of pleomorphic liposarcoma as potential mimic of metastatic carcinoma. ( 21464872 )
2011
39
Metachronous pleomorphic liposarcoma and melanoma: a rare case report. ( 21393919 )
2011
40
Pleomorphic liposarcoma originating from intracranial dura mater. ( 19727564 )
2010
41
Epithelioid variant of a pleomorphic liposarcoma displaying arborizing vascular arrangements on cytology smears: a case report of an interesting cytomorphologic pattern in an uncommon tumor. ( 21053578 )
2010
42
Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature. ( 20604797 )
2010
43
Primary pleomorphic liposarcoma: a rare mediastinal tumor. ( 20719913 )
2010
44
Radiological-pathological correlation of pleomorphic liposarcoma of the anterior mediastinum in a 17-year-old girl. ( 20827472 )
2010
45
Metastasis after resection of huge primary pericardial pleomorphic liposarcoma with cardiopulmonary bypass. ( 20333575 )
2010
46
Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. ( 20588177 )
2010
47
Cytopathological diagnosis of metastatic pleomorphic liposarcoma in the lung: a report of a case correlated with the histopathology of the primary tumour. ( 19373911 )
2009
48
Pleomorphic liposarcoma of the axilla metastatic to the pancreas. ( 19590203 )
2009
49
Analysis of CHOP rearrangement in pleomorphic liposarcomas using fluorescence in situ hybridization. ( 19037998 )
2009
50
Pleomorphic liposarcoma of the pectoralis major muscle in an elderly man: report of a case and review of literature. ( 20160372 )
2009

Variations for Pleomorphic Liposarcoma

Copy number variations for Pleomorphic Liposarcoma from CNVD:

7 (show top 50) (show all 56)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 27943 1 216302655 221524000 Copy number DISP1 Pleomorphic liposarcoma
2 27944 1 216302655 221524000 Copy number MARK1 Pleomorphic liposarcoma
3 27945 1 216302655 221524000 Copy number MIA3 Pleomorphic liposarcoma
4 27946 1 216302655 221524000 Copy number TP53BP2 Pleomorphic liposarcoma
5 35867 1 68313202 77461343 Copy number MSH4 Pleomorphic liposarcoma
6 35868 1 68313202 77461343 Copy number TNNI3K Pleomorphic liposarcoma
7 38609 10 103687999 105303029 Copy number NFKB2 Pleomorphic liposarcoma
8 38610 10 103687999 105303029 Copy number SUFU Pleomorphic liposarcoma
9 39750 10 119097873 135323432 Copy number CTBP2 Pleomorphic liposarcoma
10 39751 10 119097873 135323432 Copy number FGFR2 Pleomorphic liposarcoma
11 45183 10 68571354 70982955 Copy number CCAR1 Pleomorphic liposarcoma
12 45184 10 68571354 70982955 Copy number CXXC6 Pleomorphic liposarcoma
13 45570 10 72407412 76912067 Copy number MYST4 Pleomorphic liposarcoma
14 67858 12 456768 1673782 Copy number ADIPOR2 Pleomorphic liposarcoma
15 67859 12 456768 1673782 Copy number ERC1 Pleomorphic liposarcoma
16 67860 12 456768 1673782 Copy number RAD52 Pleomorphic liposarcoma
17 67861 12 456768 1673782 Copy number WNT5B Pleomorphic liposarcoma
18 77885 13 47917390 48154504 Copy number RB1 Pleomorphic liposarcoma
19 104128 16 67103973 69257715 Copy number CDH1 Pleomorphic liposarcoma
20 104129 16 67103973 69257715 Copy number CDH3 Pleomorphic liposarcoma
21 104130 16 67103973 69257715 Copy number CTF8 Pleomorphic liposarcoma
22 104131 16 67103973 69257715 Copy number FUK Pleomorphic liposarcoma
23 104132 16 67103973 69257715 Copy number NQO1 Pleomorphic liposarcoma
24 109091 17 24079567 27921023 Copy number NF1 Pleomorphic liposarcoma
25 109092 17 24079567 27921023 Copy number SUZ12 Pleomorphic liposarcoma
26 116531 17 6791092 7741807 Copy number TP53 Pleomorphic liposarcoma
27 127073 19 24161928 40254153 Copy number CCNE1 Pleomorphic liposarcoma
28 127074 19 24161928 40254153 Copy number CEBPA Pleomorphic liposarcoma
29 127075 19 24161928 40254153 Copy number LRP3 Pleomorphic liposarcoma
30 127413 19 32690406 34776985 Copy number UQCRFS1 Pleomorphic liposarcoma
31 127995 19 38552698 38678914 Copy number CEBPG Pleomorphic liposarcoma
32 128402 19 40680588 41040430 Copy number ETV2 Pleomorphic liposarcoma
33 128403 19 40680588 41040430 Copy number MLL4 Pleomorphic liposarcoma
34 128404 19 40680588 41040430 Copy number PSENEN Pleomorphic liposarcoma
35 164748 22 39296203 46069760 Copy number EP300 Pleomorphic liposarcoma
36 164749 22 39296203 46069760 Copy number MKL1 Pleomorphic liposarcoma
37 164750 22 39296203 46069760 Copy number PPARA Pleomorphic liposarcoma
38 164751 22 39296203 46069760 Copy number ST13 Pleomorphic liposarcoma
39 164752 22 39296203 46069760 Copy number XRCC6 Pleomorphic liposarcoma
40 192151 5 10731281 11126282 Copy number DAP Pleomorphic liposarcoma
41 192512 5 11413893 15762298 Copy number CTNND2 Pleomorphic liposarcoma
42 192513 5 11413893 15762298 Copy number FBXL7 Pleomorphic liposarcoma
43 196379 5 165712 5444231 Copy number TERT Pleomorphic liposarcoma
44 198926 5 32750418 45758751 Copy number AMACR Pleomorphic liposarcoma
45 198927 5 32750418 45758751 Copy number C1QTNF3 Pleomorphic liposarcoma
46 198928 5 32750418 45758751 Copy number LIFR Pleomorphic liposarcoma
47 198929 5 32750418 45758751 Copy number RAD1 Pleomorphic liposarcoma
48 198930 5 32750418 45758751 Copy number SKP2 Pleomorphic liposarcoma
49 223658 7 23715756 32063427 Copy number HOXA11 Pleomorphic liposarcoma
50 223659 7 23715756 32063427 Copy number HOXA13 Pleomorphic liposarcoma

Expression for Pleomorphic Liposarcoma

Search GEO for disease gene expression data for Pleomorphic Liposarcoma.

Pathways for Pleomorphic Liposarcoma

Pathways related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.5 ACTC1 DES KRT8 MUC1 VIM
2
Show member pathways
11.37 DES KRT8 VIM
3 10.99 ACTC1 DES VIM
4 10.87 CDKN2A MDM2
5 10.66 CDKN2A MDM2
6
Show member pathways
10.6 CDKN2A MDM2

GO Terms for Pleomorphic Liposarcoma

Cellular components related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.28 ACTC1 CDKN2A DES INHA KRT8 MDM2
2 intermediate filament GO:0005882 9.13 DES KRT8 VIM

Biological processes related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein destabilization GO:0031648 9.37 CDKN2A MDM2
2 positive regulation of gene expression GO:0010628 9.33 ACTC1 MDM2 VIM
3 negative regulation of phosphorylation GO:0042326 9.32 CDKN2A INHA
4 intermediate filament organization GO:0045109 9.26 DES VIM
5 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM
6 amyloid fibril formation GO:1990000 8.65 MDM2

Molecular functions related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 SUMO transferase activity GO:0019789 8.96 CDKN2A MDM2
2 disordered domain specific binding GO:0097718 8.85 MDM2
3 scaffold protein binding GO:0097110 8.8 KRT8 MDM2 VIM

Sources for Pleomorphic Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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