PLS
MCID: PLM019
MIFTS: 43

Pleomorphic Liposarcoma (PLS) malady

Categories: Rare diseases, Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pleomorphic Liposarcoma

Aliases & Descriptions for Pleomorphic Liposarcoma:

Name: Pleomorphic Liposarcoma 12 56 14
Liposarcoma, Pleomorphic 69
Liposarcoma Pleomorphic 52
Pls 56

Characteristics:

Orphanet epidemiological data:

56
pleomorphic liposarcoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:5702
MeSH 42 D008080
NCIt 47 C3705
SNOMED-CT 64 112683004 404071006
Orphanet 56 ORPHA99969
UMLS via Orphanet 70 C0205825
ICD10 via Orphanet 34 C49.9
UMLS 69 C0205825

Summaries for Pleomorphic Liposarcoma

MalaCards based summary : Pleomorphic Liposarcoma, also known as liposarcoma, pleomorphic, is related to mesenchymoma and lateral sclerosis, and has symptoms including subcutaneous nodule An important gene associated with Pleomorphic Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Doxorubicin and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and liver, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Pleomorphic Liposarcoma

Diseases related to Pleomorphic Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
id Related Disease Score Top Affiliating Genes
1 mesenchymoma 29.6 MUC1 VIM
2 lateral sclerosis 11.7
3 primary lateral sclerosis, juvenile 11.6
4 primary lateral sclerosis, adult, 1 11.6
5 pityriasis lichenoides 11.1
6 papillon-lefevre syndrome 10.9
7 motor neuron disease 10.8
8 proteus-like syndrome 10.8
9 liposarcoma 10.7
10 aortic aneurysm 10.3 CDKN2A MDM2
11 apocrine sweat gland neoplasm 10.3 CDKN2A MDM2
12 endometrial squamous cell carcinoma 10.3 CDKN2A MDM2
13 lucey-driscoll syndrome 10.3 MUC1 S100B
14 secondary pulmonary hemosiderosis 10.3 MUC1 S100B
15 myelinoclastic diffuse sclerosis 10.2 MUC1 S100B
16 invasive mole 10.2 MUC1 S100B
17 cervical verrucous carcinoma 10.2 CDKN2A MDM2
18 pemphigus vegetans 10.2 MUC1 S100B
19 trombiculiasis 10.2 MUC1 S100B
20 corneal intraepithelial neoplasm 10.2 MUC1 S100B
21 porokeratosis 10.2 MUC1 S100B
22 lacrimal gland squamous cell carcinoma 10.2 CDKN2A KRT8
23 endocardium cancer 10.2 MUC1 S100B
24 precursor t-lymphoblastic lymphoma/leukemia 10.2 MUC1 S100B
25 invasive malignant thymoma 10.2 DES MUC1
26 extraosseous osteosarcoma 10.2 DES MDM2
27 intrahepatic bile duct cystadenoma 10.2 DES S100B
28 embryonal testis carcinoma 10.2 KRT8 MUC1
29 tumor of exocrine pancreas 10.2 CDKN2A MUC1
30 pericardium leiomyoma 10.2 ACTC1 CDKN2A
31 foix-alajouanine syndrome 10.2 DES S100B
32 vulvar alveolar soft part sarcoma 10.2 CDKN2A KRT8
33 bone deterioration disease 10.2 DES S100B
34 mucinous cystadenocarcinoma 10.2 ACTC1 MUC1
35 pulmonary neuroendocrine tumor 10.2 MUC1 S100B
36 pediculus humanus corporis infestation 10.2 KRT8 S100B
37 acute generalized exanthematous pustulosis 10.2 ACTC1 S100B
38 pseudohermaphrodism anorectal anomalies 10.1 DES MUC1
39 vascular myelopathy 10.1 CDKN2A MDM2 S100B
40 chiasmal syndrome 10.1 ACTC1 S100B
41 paraphimosis 10.1 ACTC1 CDKN2A
42 sarcomatoid mesothelioma 10.1 KRT8 MUC1
43 adenoid squamous cell carcinoma 10.1 CDKN2A KRT8
44 hemangioma of liver 10.1 ACTC1 S100B
45 thymus squamous cell carcinoma 10.1 CDKN2A KRT8
46 uterine corpus leiomyomatosis 10.1 CDKN2A MUC1 S100B
47 monostotic fibrous dysplasia 10.1 CDKN2A MUC1 S100B
48 pathologic nystagmus 10.1 CDKN2A MUC1 S100B
49 grade iii astrocytoma 10.1 CDKN2A MDM2 S100B
50 oral erosive lichen 10.1 ACTC1 DES

Graphical network of the top 20 diseases related to Pleomorphic Liposarcoma:



Diseases related to Pleomorphic Liposarcoma

Symptoms & Phenotypes for Pleomorphic Liposarcoma

Human phenotypes related to Pleomorphic Liposarcoma:

56 32
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 56 32 Very frequent (99-80%) HP:0001482

MGI Mouse Phenotypes related to Pleomorphic Liposarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 ACTC1 CDKN2A DES KRT8 MDM2 VIM
2 homeostasis/metabolism MP:0005376 9.56 VIM ACTC1 CDKN2A CTSC DES KRT8
3 muscle MP:0005369 9.02 ACTC1 CDKN2A DES MDM2 VIM

Drugs & Therapeutics for Pleomorphic Liposarcoma

Drugs for Pleomorphic Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2, Phase 3, Phase 1 23214-92-8 31703
2
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
3
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
4
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
6
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
7
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
8
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
9
Gemcitabine Approved Phase 3,Phase 2 95058-81-4 60750
10
Mechlorethamine Approved Phase 3,Phase 2 51-75-2 4033
11
Dacarbazine Approved, Investigational Phase 3 4342-03-4 5351166
12
Trabectedin Approved, Investigational Phase 3 114899-77-3 108150
13
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
14
Cyproheptadine Approved Phase 3 129-03-3 2913
15
Doxil Approved June 1999 Phase 2, Phase 3, Phase 1 31703
16
Docetaxel Approved May 1996, Investigational Phase 3 114977-28-5 148124 9877265
17 Alkylating Agents Phase 3,Phase 2
18 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
19 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
20 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
21 Etoposide phosphate Phase 3,Phase 2
22 Anti-Infective Agents Phase 3,Phase 2
23 Immunosuppressive Agents Phase 3,Phase 2
24 Isophosphamide mustard Phase 3,Phase 2
25 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
26 Antimitotic Agents Phase 3,Phase 2
27 Antirheumatic Agents Phase 3,Phase 2
28 Antineoplastic Agents, Alkylating Phase 3,Phase 2
29 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
30 Antimetabolites Phase 3,Phase 2
31 Antimetabolites, Antineoplastic Phase 3,Phase 2
32 Antiviral Agents Phase 3,Phase 2
33
Histamine Phosphate Phase 3 51-74-1 65513
34
Serotonin Phase 3 50-67-9 5202
35 Serotonin Agents Phase 3
36 Serotonin Antagonists Phase 3
37 Gastrointestinal Agents Phase 3
38 Neurotransmitter Agents Phase 3
39 Histamine Antagonists Phase 3
40 Histamine H1 Antagonists Phase 3
41 Dermatologic Agents Phase 3
42 Anti-Allergic Agents Phase 3
43 Antipruritics Phase 3
44
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
45
Lenograstim Approved Phase 2 135968-09-1
46
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
47
Pembrolizumab Approved Phase 2 1374853-91-4
48
Maleic acid Experimental Phase 2 110-16-7 444266
49 Imatinib Mesylate Phase 2 123596
50 Angiogenesis Inhibitors Phase 2

Interventional clinical trials:

(show all 20)
id Name Status NCT ID Phase
1 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3
2 Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy Recruiting NCT01710176 Phase 3
3 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
4 A Study of Doxorubicin Plus Olaratumab (LY3012207) in Participants With Advanced or Metastatic Soft Tissue Sarcoma Active, not recruiting NCT02451943 Phase 3
5 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
6 Rosiglitazone in Treating Patients With Liposarcoma Completed NCT00004180 Phase 2
7 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2
8 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2
9 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2
10 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2
11 SARC028: A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas Recruiting NCT02301039 Phase 2
12 Doxorubicin With Upfront Dexrazoxane Plus Olaratumab for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma Recruiting NCT02584309 Phase 2
13 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2
14 Activity and Tolerability of Pazopanib in Advanced and/or Metastatic Liposarcoma. A Phase II Clinical Trial Active, not recruiting NCT01692496 Phase 2
15 Alisertib in Treating Patients With Advanced or Metastatic Sarcoma Active, not recruiting NCT01653028 Phase 2
16 Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery Not yet recruiting NCT02923778 Phase 2
17 Efficacy and Safety of Plitidepsin in Patients With Advanced Unresectable or Metastatic, Relapsed/Refractory, Dedifferentiated Liposarcoma (DLPS): an Exploratory Phase II Multicenter Trial Terminated NCT01876043 Phase 2
18 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1
19 Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery Recruiting NCT03009201 Phase 1
20 Detection of Circulating Tumor Cells in Patients With Sarcomas Recruiting NCT02983539

Search NIH Clinical Center for Pleomorphic Liposarcoma

Genetic Tests for Pleomorphic Liposarcoma

Anatomical Context for Pleomorphic Liposarcoma

MalaCards organs/tissues related to Pleomorphic Liposarcoma:

39
Breast, Bone, Liver, Uterus, Prostate, Cervix, Ovary

Publications for Pleomorphic Liposarcoma

Articles related to Pleomorphic Liposarcoma:

(show top 50) (show all 84)
id Title Authors Year
1
Association of Li-Fraumeni Syndrome With Small Cell Carcinoma of the Ovary, Hypercalcemic Type and Concurrent Pleomorphic Liposarcoma of the Cervix. ( 28177947 )
2017
2
Cellular Angiofibroma With Sarcomatous Transformation Showing Pleomorphic Liposarcoma-Like and Atypical Lipomatous Tumor-Like Features. ( 26760687 )
2016
3
Primary dermal pleomorphic liposarcoma: utility of adipophilin and MDM2/CDK4 immunostainings. ( 27778364 )
2016
4
Cutaneous metastasis of pleomorphic liposarcoma to the scalp: an elusive diagnosis. ( 26968423 )
2016
5
Primary pleomorphic liposarcoma of the spine. Case report and review of the literature. ( 27351623 )
2016
6
Pleomorphic liposarcoma of the inferior vena cava. ( 25590403 )
2015
7
Pleomorphic liposarcoma arising in a malignant phyllodes tumor of breast: A rare occurrence. ( 26881623 )
2015
8
Primary pleomorphic liposarcoma of the thoracic epidural space: case report. ( 26343245 )
2015
9
Pleomorphic Liposarcoma Arising in a Lipoleiomyosarcoma of the Uterus: Report of a Case With Genetic Profiling by a Next Generation Sequencing Panel. ( 26598981 )
2015
10
The surgical management of a giant pleomorphic liposarcoma of the chest wall. ( 25392049 )
2014
11
Primary mediastinal pleomorphic liposarcoma involving the superior vena cava. ( 26767011 )
2014
12
Rhabdomyosarcoma with pseudolipoblasts arising in ovarian carcinosarcoma: a distinctive postchemotherapy morphologic variant mimicking pleomorphic liposarcoma. ( 24587930 )
2014
13
Small bowel pleomorphic liposarcoma: a rare cause of gastrointestinal bleeding. ( 25161780 )
2014
14
Pleomorphic liposarcoma of the hand. ( 24870378 )
2014
15
Pleomorphic liposarcoma: A cytologic study of five cases. ( 24652822 )
2014
16
Pleomorphic liposarcoma: a clinicopathological, immunohistochemical and molecular cytogenetic study of 32 additional cases. ( 24274714 )
2013
17
Primary pleomorphic liposarcoma of liver: a case report and review of the literature. ( 25374715 )
2013
18
Dedifferentiated liposarcoma and pleomorphic liposarcoma: A comparative study of cytomorphology and MDM2/CDK4 expression on fine-needle aspiration. ( 24227706 )
2013
19
Liver Metastasis of Extremity Pleomorphic Liposarcoma Treated with Hepatic Resection. ( 23959373 )
2013
20
Immediate reconstruction of the chest wall by latissimus dorsi and vertical rectus abdominis musculocutaneous flaps after radical mastectomy for a huge pleomorphic liposarcoma. ( 23350740 )
2013
21
p14(ARF) methylation is a common event in the pathogenesis and progression of myxoid and pleomorphic liposarcoma. ( 23918242 )
2013
22
Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature. ( 23651098 )
2013
23
Muir-Torre syndrome-associated pleomorphic liposarcoma arising in a previous radiation field. ( 23299928 )
2013
24
Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. ( 22472959 )
2012
25
Primary pleomorphic liposarcoma of the orbit: a case report. ( 22551368 )
2012
26
Combined cutaneous sarcoma: pleomorphic liposarcoma and conventional osteosarcoma-the so-called malignant mesenchymoma. ( 23082265 )
2012
27
Primary orbital pleomorphic liposarcoma: an aggressive course. ( 22460675 )
2012
28
Earlier detection of bone metastases from pleomorphic liposarcoma in a pediatric patient by FDG PET/CT than planar 99mTc MDP bone scan. ( 22475918 )
2012
29
Prostatic adenocarcinoma metastatic to pleomorphic liposarcoma, a "collision phenomenon": report of a case with review of pelvic collision tumors. ( 21904691 )
2011
30
Primary pleomorphic liposarcoma of breast: a rare case report. ( 21393893 )
2011
31
Metachronous pleomorphic liposarcoma and melanoma: a rare case report. ( 21393919 )
2011
32
Orbital pleomorphic liposarcoma in an eight-year-old boy. ( 21417910 )
2011
33
Primary pleomorphic liposarcoma of bone in an adolescent: imaging features of a rare entity. ( 21573914 )
2011
34
Pleomorphic liposarcoma of the uterine corpus with focal smooth muscle differentiation. ( 21464725 )
2011
35
Epithelioid variant of pleomorphic liposarcoma as potential mimic of metastatic carcinoma. ( 21464872 )
2011
36
Pleomorphic liposarcoma: clinical observations and molecular variables. ( 21598240 )
2011
37
Pleomorphic liposarcoma originating from intracranial dura mater. ( 19727564 )
2010
38
Primary pleomorphic liposarcoma: a rare mediastinal tumor. ( 20719913 )
2010
39
Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature. ( 20604797 )
2010
40
Metastasis after resection of huge primary pericardial pleomorphic liposarcoma with cardiopulmonary bypass. ( 20333575 )
2010
41
Epithelioid variant of a pleomorphic liposarcoma displaying arborizing vascular arrangements on cytology smears: a case report of an interesting cytomorphologic pattern in an uncommon tumor. ( 21053578 )
2010
42
Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. ( 20588177 )
2010
43
Radiological-pathological correlation of pleomorphic liposarcoma of the anterior mediastinum in a 17-year-old girl. ( 20827472 )
2010
44
Pleomorphic liposarcoma of the axilla metastatic to the pancreas. ( 19590203 )
2009
45
Cytopathological diagnosis of metastatic pleomorphic liposarcoma in the lung: a report of a case correlated with the histopathology of the primary tumour. ( 19373911 )
2009
46
Pleomorphic liposarcoma of the pectoralis major muscle in an elderly man: report of a case and review of literature. ( 20160372 )
2009
47
Analysis of CHOP rearrangement in pleomorphic liposarcomas using fluorescence in situ hybridization. ( 19037998 )
2009
48
Primary pleomorphic liposarcoma of the liver in a dog. ( 19227140 )
2008
49
Pleomorphic liposarcoma of the foot: a case report. ( 18416844 )
2008
50
Mediastinal pleomorphic liposarcoma diagnosed by fine needle aspiration biopsy: a case report. ( 17536551 )
2007

Variations for Pleomorphic Liposarcoma

Copy number variations for Pleomorphic Liposarcoma from CNVD:

7 (show top 50) (show all 56)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 27943 1 216302655 221524000 Copy number DISP1 Pleomorphic liposarcoma
2 27944 1 216302655 221524000 Copy number MARK1 Pleomorphic liposarcoma
3 27945 1 216302655 221524000 Copy number MIA3 Pleomorphic liposarcoma
4 27946 1 216302655 221524000 Copy number TP53BP2 Pleomorphic liposarcoma
5 35867 1 68313202 77461343 Copy number MSH4 Pleomorphic liposarcoma
6 35868 1 68313202 77461343 Copy number TNNI3K Pleomorphic liposarcoma
7 38609 10 103687999 105303029 Copy number NFKB2 Pleomorphic liposarcoma
8 38610 10 103687999 105303029 Copy number SUFU Pleomorphic liposarcoma
9 39750 10 119097873 135323432 Copy number CTBP2 Pleomorphic liposarcoma
10 39751 10 119097873 135323432 Copy number FGFR2 Pleomorphic liposarcoma
11 45183 10 68571354 70982955 Copy number CCAR1 Pleomorphic liposarcoma
12 45184 10 68571354 70982955 Copy number CXXC6 Pleomorphic liposarcoma
13 45570 10 72407412 76912067 Copy number MYST4 Pleomorphic liposarcoma
14 67858 12 456768 1673782 Copy number ADIPOR2 Pleomorphic liposarcoma
15 67859 12 456768 1673782 Copy number ERC1 Pleomorphic liposarcoma
16 67860 12 456768 1673782 Copy number RAD52 Pleomorphic liposarcoma
17 67861 12 456768 1673782 Copy number WNT5B Pleomorphic liposarcoma
18 77885 13 47917390 48154504 Copy number RB1 Pleomorphic liposarcoma
19 104128 16 67103973 69257715 Copy number CDH1 Pleomorphic liposarcoma
20 104129 16 67103973 69257715 Copy number CDH3 Pleomorphic liposarcoma
21 104130 16 67103973 69257715 Copy number CTF8 Pleomorphic liposarcoma
22 104131 16 67103973 69257715 Copy number FUK Pleomorphic liposarcoma
23 104132 16 67103973 69257715 Copy number NQO1 Pleomorphic liposarcoma
24 109091 17 24079567 27921023 Copy number NF1 Pleomorphic liposarcoma
25 109092 17 24079567 27921023 Copy number SUZ12 Pleomorphic liposarcoma
26 116531 17 6791092 7741807 Copy number TP53 Pleomorphic liposarcoma
27 127073 19 24161928 40254153 Copy number CCNE1 Pleomorphic liposarcoma
28 127074 19 24161928 40254153 Copy number CEBPA Pleomorphic liposarcoma
29 127075 19 24161928 40254153 Copy number LRP3 Pleomorphic liposarcoma
30 127413 19 32690406 34776985 Copy number UQCRFS1 Pleomorphic liposarcoma
31 127995 19 38552698 38678914 Copy number CEBPG Pleomorphic liposarcoma
32 128402 19 40680588 41040430 Copy number ETV2 Pleomorphic liposarcoma
33 128403 19 40680588 41040430 Copy number MLL4 Pleomorphic liposarcoma
34 128404 19 40680588 41040430 Copy number PSENEN Pleomorphic liposarcoma
35 164748 22 39296203 46069760 Copy number EP300 Pleomorphic liposarcoma
36 164749 22 39296203 46069760 Copy number MKL1 Pleomorphic liposarcoma
37 164750 22 39296203 46069760 Copy number PPARA Pleomorphic liposarcoma
38 164751 22 39296203 46069760 Copy number ST13 Pleomorphic liposarcoma
39 164752 22 39296203 46069760 Copy number XRCC6 Pleomorphic liposarcoma
40 192151 5 10731281 11126282 Copy number DAP Pleomorphic liposarcoma
41 192512 5 11413893 15762298 Copy number CTNND2 Pleomorphic liposarcoma
42 192513 5 11413893 15762298 Copy number FBXL7 Pleomorphic liposarcoma
43 196379 5 165712 5444231 Copy number TERT Pleomorphic liposarcoma
44 198926 5 32750418 45758751 Copy number AMACR Pleomorphic liposarcoma
45 198927 5 32750418 45758751 Copy number C1QTNF3 Pleomorphic liposarcoma
46 198928 5 32750418 45758751 Copy number LIFR Pleomorphic liposarcoma
47 198929 5 32750418 45758751 Copy number RAD1 Pleomorphic liposarcoma
48 198930 5 32750418 45758751 Copy number SKP2 Pleomorphic liposarcoma
49 223658 7 23715756 32063427 Copy number HOXA11 Pleomorphic liposarcoma
50 223659 7 23715756 32063427 Copy number HOXA13 Pleomorphic liposarcoma

Expression for Pleomorphic Liposarcoma

Search GEO for disease gene expression data for Pleomorphic Liposarcoma.

Pathways for Pleomorphic Liposarcoma

Pathways related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.5 ACTC1 DES KRT8 MUC1 VIM
2
Show member pathways
11.37 DES KRT8 VIM
3 10.99 ACTC1 DES VIM
4 10.87 CDKN2A MDM2
5 10.66 CDKN2A MDM2
6
Show member pathways
10.6 CDKN2A MDM2

GO Terms for Pleomorphic Liposarcoma

Cellular components related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 DES KRT8 VIM

Biological processes related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein destabilization GO:0031648 9.16 CDKN2A MDM2
2 intermediate filament organization GO:0045109 8.96 DES VIM
3 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 CTSC DES MDM2 S100B VIM
2 SUMO transferase activity GO:0019789 9.16 CDKN2A MDM2
3 scaffold protein binding GO:0097110 8.8 KRT8 MDM2 VIM

Sources for Pleomorphic Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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