MCID: PLM019
MIFTS: 48

Pleomorphic Liposarcoma malady

Cancer diseases, Rare diseases categories

Summaries for Pleomorphic Liposarcoma

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MalaCards based summary: Pleomorphic Liposarcoma, also known as pls, is related to liposarcoma and sarcoma, and has symptoms including abnormality of the skin, sarcoma and neoplasm of the lung. An important gene associated with Pleomorphic Liposarcoma is INHA (inhibin, alpha), and among its related pathways is Transcriptional misregulation in cancer. The compounds nad+ and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and skin, and related mouse phenotypes are reproductive system and hematopoietic system.

Aliases & Classifications for Pleomorphic Liposarcoma

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Sources:
10Disease Ontology, 45Novoseek, 49Orphanet, 62UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Pleomorphic Liposarcoma, Aliases & Descriptions:

Name: Pleomorphic Liposarcoma 10 49
Pls 49 62
 
Liposarcoma, Pleomorphic 62
Liposarcoma Pleomorphic 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 49 
Rare tumors


Characteristics (Orphanet epidemiological data):

49
pleomorphic liposarcoma:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adult; Age of death: adult


External Ids:

Disease Ontology10 DOID:5702
MeSH35 D008080
NCIt40 C3705
Orphanet49 99969
ICD10 via Orphanet28 C49
UMLS via Orphanet63 C0205825

Related Diseases for Pleomorphic Liposarcoma

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Diseases related to Pleomorphic Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma31.6MDM2, CALB2, VIM, FUS
2sarcoma30.5FUS, VIM, CALB2, MDM2
3fibrous histiocytoma30.5VIM, FUS
4rhabdomyosarcoma30.4MDM2, CALB2, VIM, INHA
5epithelioid sarcoma30.3CALB2, VIM
6fibroma30.3CALB2, VIM
7adenocarcinoma30.2INHA, VIM, CALB2, MDM2
8melanoma30.2INHA, VIM, CALB2, MDM2
9myocardial infarction10.4
10lateral sclerosis10.4
11primary lateral sclerosis, juvenile10.4
12liposarcoma of bone10.3
13histiocytoma10.3
14mediastinitis10.3
15dedifferentiated liposarcoma10.3
16primary lateral sclerosis, adult, 110.3
17acute myocardial infarction10.2
18lymphogranuloma venereum10.2
19cardiogenic shock10.2
20muir-torre syndrome10.2
21hepatitis10.2
22neurofibromatosis10.2
23malignant mesenchymoma10.2
24mesenchymoma10.2
25ovarian carcinosarcoma10.2
26pleomorphic rhabdomyosarcoma10.2
27prostate adenocarcinoma10.2
28prostatitis10.2
29thyroiditis10.2
30papillon-lefevre syndrome10.1
31coronary artery disease10.1
32atherosclerosis10.1
33artery disease10.1
34heart cancer10.1
35allergic encephalomyelitis10.1
36malignant peritoneal mesothelioma10.0CALB2
37essential tremor10.0VIM
38giant cell glioblastoma10.0MDM2
39peripheral primitive neuroectodermal tumor10.0FUS
40sex cord-gonadal stromal tumor10.0INHA, CALB2
41sertoli-leydig cell tumor10.0INHA, CALB2
42adenofibroma10.0CALB2, INHA
43endometrial stromal sarcoma10.0VIM, INHA
44chordoma10.0INHA, VIM
45adenomatoid tumor10.0CALB2, VIM
46endometrial cancer10.0INHA, CALB2
47angiosarcoma10.0CALB2, VIM
48leydig cell tumor10.0INHA, CALB2
49adrenocortical carcinoma10.0CALB2, INHA
50adrenal cortical adenoma10.0INHA, CALB2

Graphical network of the top 20 diseases related to Pleomorphic Liposarcoma:



Diseases related to pleomorphic liposarcoma

Symptoms for Pleomorphic Liposarcoma

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Symptoms:

 49
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • early death/lethality

HPO human phenotypes related to Pleomorphic Liposarcoma:

id Description Frequency HPO Source Accession
1 abnormality of the skin hallmark (90%) HP:0000951
2 sarcoma hallmark (90%) HP:0100242
3 neoplasm of the lung occasional (7.5%) HP:0100526

Drugs & Therapeutics for Pleomorphic Liposarcoma

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Drug clinical trials:

Search ClinicalTrials for Pleomorphic Liposarcoma

Search NIH Clinical Center for Pleomorphic Liposarcoma

Genetic Tests for Pleomorphic Liposarcoma

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Anatomical Context for Pleomorphic Liposarcoma

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MalaCards organs/tissues related to Pleomorphic Liposarcoma:

33
Lung, Breast, Skin, Bone, Liver, Smooth muscle, Pancreas, Thyroid, Uterus, Prostate

Animal Models for Pleomorphic Liposarcoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Liposarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2MDM2, VIM, INHA, FUS
2MP:00053978.1FUS, INHA, VIM, MDM2
3MP:00053788.1MDM2, VIM, INHA, FUS
4MP:00053868.0MDM2, CALB2, VIM, FUS
5MP:00053878.0FUS, INHA, VIM, MDM2
6MP:00036317.7FUS, VIM, CALB2, MDM2

Publications for Pleomorphic Liposarcoma

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Articles related to Pleomorphic Liposarcoma:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Small bowel pleomorphic liposarcoma: a rare cause of gastrointestinal bleeding. (25161780)
2014
2
Rhabdomyosarcoma with pseudolipoblasts arising in ovarian carcinosarcoma: a distinctive postchemotherapy morphologic variant mimicking pleomorphic liposarcoma. (24587930)
2014
3
Pleomorphic liposarcoma: A cytologic study of five cases. (24652822)
2014
4
Immediate reconstruction of the chest wall by latissimus dorsi and vertical rectus abdominis musculocutaneous flaps after radical mastectomy for a huge pleomorphic liposarcoma. (23350740)
2013
5
p14(ARF) methylation is a common event in the pathogenesis and progression of myxoid and pleomorphic liposarcoma. (23918242)
2013
6
Pleomorphic liposarcoma: a clinicopathological, immunohistochemical and molecular cytogenetic study of 32 additional cases. (24274714)
2013
7
Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature. (23651098)
2013
8
Muir-Torre syndrome-associated pleomorphic liposarcoma arising in a previous radiation field. (23299928)
2013
9
Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. (22472959)
2012
10
Primary pleomorphic liposarcoma of the orbit: a case report. (22551368)
2012
11
Pleomorphic liposarcoma: clinical observations and molecular variables. (21598240)
2011
12
Orbital pleomorphic liposarcoma in an eight-year-old boy. (21417910)
2011
13
Metachronous pleomorphic liposarcoma and melanoma: a rare case report. (21393919)
2011
14
Primary pleomorphic liposarcoma of breast: a rare case report. (21393893)
2011
15
Primary pleomorphic liposarcoma of bone in an adolescent: imaging features of a rare entity. (21573914)
2011
16
Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature. (20604797)
2010
17
Pleomorphic liposarcoma originating from intracranial dura mater. (19727564)
2010
18
Metastasis after resection of huge primary pericardial pleomorphic liposarcoma with cardiopulmonary bypass. (20333575)
2010
19
Epithelioid variant of a pleomorphic liposarcoma displaying arborizing vascular arrangements on cytology smears: a case report of an interesting cytomorphologic pattern in an uncommon tumor. (21053578)
2010
20
Radiological-pathological correlation of pleomorphic liposarcoma of the anterior mediastinum in a 17-year-old girl. (20827472)
2010
21
Pleomorphic liposarcoma of the axilla metastatic to the pancreas. (19590203)
2009
22
Analysis of CHOP rearrangement in pleomorphic liposarcomas using fluorescence in situ hybridization. (19037998)
2009
23
Pleomorphic liposarcoma of the foot: a case report. (18416844)
2008
24
Mediastinal pleomorphic liposarcoma diagnosed by fine needle aspiration biopsy: a case report. (17536551)
2007
25
Epithelioid variant of pleomorphic liposarcoma in a heifer. (17645889)
2007
26
Pathology quiz case 2. Pleomorphic liposarcoma (PLS) of the retrotonsillar fossa. (17372093)
2007
27
Primary pleomorphic liposarcoma of bone: MRI findings and review of the literature. (16175410)
2006
28
Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances. (15702084)
2005
29
Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript. (15720420)
2005
30
Pulmonary pleomorphic liposarcoma. (16164258)
2005
31
Primary pleomorphic liposarcoma of the parotid gland: a case report and review of the literature. (15547814)
2004
32
Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. (15371941)
2004
33
Focal divergent chondrosarcomatous differentiation in a primary pleomorphic liposarcoma and expression of transforming growth factor beta. (14765280)
2004
34
Pleomorphic liposarcoma in a ten year old child. (15552292)
2004
35
Pleomorphic liposarcoma of the uterus: case report and literature review. (14501826)
2003
36
Primary purely intradermal pleomorphic liposarcoma. (12950504)
2003
37
Pleomorphic liposarcoma metastatic to the thyroid gland. (11805476)
2002
38
Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma. (12036902)
2002
39
Pleomorphic liposarcoma. (11757868)
2001
40
Fine needle aspiration of pleomorphic liposarcoma of the breast: revised diagnosis. (11726108)
2001
41
Pleomorphic liposarcoma of a young woman following radiotherapy for epithelioid sarcoma. (11173662)
2000
42
Epithelioid variant of pleomorphic liposarcoma: a study of 12 cases of a distinctive variant of high-grade liposarcoma. (10430277)
1999
43
Mesenteric pleomorphic liposarcoma in an adolescent. (9126049)
1997
44
Pleomorphic liposarcoma of the pterygomandibular space involving the maxilla. (7614211)
1995
45
Ultrastructural characteristics of a pleomorphic liposarcoma. A possible involvement of myofibroblast. (3630699)
1987
46
Pleomorphic liposarcoma in an aged rat. (3712904)
1986
47
Case report 172: pleomorphic liposarcoma, grade IV, of the soft tissue, arising in generalized plexiform neurofibromatosis. (6800037)
1981
48
Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. (223963)
1979
49
Primary pleomorphic liposarcoma of the larynx. (650725)
1978
50
Ultrastructural observations in pleomorphic liposarcoma. (212174)
1978

Variations for Pleomorphic Liposarcoma

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Expression for genes affiliated with Pleomorphic Liposarcoma

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Search GEO for disease gene expression data for Pleomorphic Liposarcoma.

Pathways for genes affiliated with Pleomorphic Liposarcoma

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Pathways related to Pleomorphic Liposarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MDM2, FUS

Compounds for genes affiliated with Pleomorphic Liposarcoma

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Compounds related to Pleomorphic Liposarcoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1nad+459.8MDM2, INHA
2mucicarmine459.5CALB2, VIM
3b 723459.5VIM, CALB2
4roscovitine459.5MDM2, VIM
5vinblastine45 51 1311.4MDM2, VIM
6gefitinib45 51 1311.4MDM2, VIM
7biotin45 26 1311.4INHA, VIM
8thymidylate459.3MDM2, VIM
9vincristine45 51 1311.3MDM2, VIM
10steroid459.3INHA, CALB2, MDM2
11adriamycin459.2MDM2, VIM
125-hydroxytryptamine459.2VIM, CALB2
13choline45 26 1311.1CALB2, VIM
14valine459.1MDM2, VIM
15zinc45 2610.1FUS, CALB2, MDM2
16hematoxylin459.1CALB2, VIM, INHA
17hyaluronic acid45 2610.0CALB2, VIM
18estradiol45 26 1311.0MDM2, VIM, INHA
19cyclic amp45 2610.0MDM2, VIM, INHA
20oligonucleotide459.0MDM2, VIM, INHA
21paclitaxel45 51 1311.0VIM, CALB2, MDM2
22alanine458.9MDM2, VIM, INHA
23glutamate458.8MDM2, CALB2, VIM
245-aza-2deoxycytidine458.8MDM2, VIM
25paraffin458.5MDM2, CALB2, VIM, INHA
26progesterone45 30 61 26 1312.5INHA, VIM, CALB2, MDM2
27testosterone45 61 26 1311.5MDM2, CALB2, VIM, INHA
28estrogen458.5INHA, VIM, CALB2, MDM2

GO Terms for genes affiliated with Pleomorphic Liposarcoma

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Molecular functions related to Pleomorphic Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:00971108.8MDM2, VIM
2identical protein bindingGO:00428028.5MDM2, VIM, FUS

Products for genes affiliated with Pleomorphic Liposarcoma

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Sources for Pleomorphic Liposarcoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet