PLS
MCID: PLM019
MIFTS: 42

Pleomorphic Liposarcoma (PLS) malady

Cancer category

Summaries for Pleomorphic Liposarcoma

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33MalaCards
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MalaCards: Pleomorphic Liposarcoma, also known as liposarcoma, pleomorphic, is related to fibrous histiocytoma and myxoid liposarcoma, and has symptoms including early death/lethality, subcutaneous nodules/lipomas/tumefaction/swelling and lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer. An important gene associated with Pleomorphic Liposarcoma is INHA (inhibin, alpha), and among its related pathways is Aurora A signaling. The compounds roscovitine and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include liver, tongue and lung, and related mouse phenotypes are reproductive system and behavior/neurological.

Aliases & Classifications for Pleomorphic Liposarcoma

Sources:
8Disease Ontology, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Characteristics (Orphanet epidemiological data):

49
pleomorphic liposarcoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

pleomorphic liposarcoma 8 49
liposarcoma, pleomorphic 61
papillon-lefevre disease 61
liposarcoma pleomorphic 45
pls 49


External Ids:

Disease Ontology8 DOID:5702
NCIt40 C3705
MeSH35 D008080
ICD10 via Orphanet26 C49
SNOMED-CT via Orphanet58 112683004, 404071006
UMLS via Orphanet62 C0205825

Related Diseases for Pleomorphic Liposarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pleomorphic Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous histiocytoma30.4VIM, FUS
2myxoid liposarcoma30.4MDM2, FUS
3breast liposarcoma10.5
4lateral sclerosis10.4
5dedifferentiated liposarcoma10.4
6juvenile primary lateral sclerosis10.3
7clear cell acanthoma10.3
8pleomorphic carcinoma10.3
9cutaneous liposarcoma10.3
10pleomorphic malignant fibrous histiocytoma10.3
11lymphogranuloma venereum10.2
12cardiogenic shock10.2
13neurofibromatosis10.1
14muir-torre syndrome10.1
15larynx liposarcoma10.1
16pediatric liposarcoma10.1
17mediastinum liposarcoma10.1
18intracranial liposarcoma10.1
19plexiform neurofibroma10.1
20adenocarcinoma10.1
21stroke, ischemic10.1
22coronary artery disease,10.1
23papillon-lefevre disease10.1
24acute myocardial infarction10.1
25atherosclerosis10.1
26allergic encephalomyelitis10.1
27cystadenoma10.0INHA
28malignant peritoneal mesothelioma10.0CALB2
29thymic carcinoma10.0CALB2
30hemangioblastoma10.0INHA
31sertoli-leydig cell tumor10.0CALB2, INHA
32leydig cell tumor10.0CALB2, INHA
33adenofibroma10.0CALB2, INHA
34seminoma10.0INHA, CALB2
35giant cell glioblastoma10.0MDM2
36von hippel-lindau disease10.0INHA
37chordoma10.0INHA, VIM
38endometrial carcinoma10.0INHA, CALB2
39angiosarcoma10.0CALB2, VIM
40endometrial stromal sarcoma10.0VIM, INHA
41essential tremor10.0VIM
42neurofibroma10.0VIM
43benign meningioma10.0MDM2
44epithelioid sarcoma10.0CALB2, VIM
45adrenocortical carcinoma10.0INHA, CALB2
46dermatofibrosarcoma10.0MDM2
47adrenal adenoma10.0CALB2, INHA
48adenomatoid tumor10.0VIM, CALB2
49malignant mesothelioma10.0VIM, CALB2
50adenoma10.0CALB2, INHA

Graphical network of the top 20 diseases related to Pleomorphic Liposarcoma:



Diseases related to pleomorphic liposarcoma

Clinical Features for Pleomorphic Liposarcoma

Sources:
49Orphanet
See all sources


Symptoms:

49 (see all 4)
  • early death/lethality
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma

Drugs & Therapeutics for Pleomorphic Liposarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pleomorphic Liposarcoma

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Liposarcoma

Search NIH Clinical Center for Pleomorphic Liposarcoma

Search CenterWatch for Pleomorphic Liposarcoma

Genetic Tests for Pleomorphic Liposarcoma

Anatomical Context for Pleomorphic Liposarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Pleomorphic Liposarcoma:

33
Liver, Tongue, Lung, Uterus, Smooth muscle, Pancreas, Thyroid, Salivary gland, Breast, Prostate, Uterus corpus

Animal Models for Pleomorphic Liposarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pleomorphic Liposarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.7FUS, DLGAP5, INHA, MDM2, VIM
2MP:00053867.6CALB2, MDM2, PRRX1, FUS, VIM

Publications for Pleomorphic Liposarcoma

Sources:
51PubMed
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Articles related to Pleomorphic Liposarcoma:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Immediate reconstruction of the chest wall by latissimus dorsi and vertical rectus abdominis musculocutaneous flaps after radical mastectomy for a huge pleomorphic liposarcoma. (23350740)
2013
2
Pleomorphic lipoma of the tongue as potential mimic of liposarcoma. (23723609)
2013
3
Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature. (23651098)
2013
4
Dedifferentiated liposarcoma and pleomorphic liposarcoma: A comparative study of cytomorphology and MDM2/CDK4 expression on fine-needle aspiration. (24227706)
2013
5
Earlier detection of bone metastases from pleomorphic liposarcoma in a pediatric patient by FDG PET/CT than planar 99mTc MDP bone scan. (22475918)
2012
6
Primary orbital pleomorphic liposarcoma: an aggressive course. (22460675)
2012
7
Orbital pleomorphic liposarcoma in an eight-year-old boy. (21417910)
2011
8
Metachronous pleomorphic liposarcoma and melanoma: a rare case report. (21393919)
2011
9
Primary pleomorphic liposarcoma of breast: a rare case report. (21393893)
2011
10
Pleomorphic liposarcoma of the uterine corpus with focal smooth muscle differentiation. (21464725)
2011
11
Pleomorphic liposarcoma originating from intracranial dura mater. (19727564)
2010
12
Metastasis after resection of huge primary pericardial pleomorphic liposarcoma with cardiopulmonary bypass. (20333575)
2010
13
Liposarcomas with mixed well-differentiated and pleomorphic features: a clinicopathologic study of 12 cases. (20431480)
2010
14
Epithelioid variant of a pleomorphic liposarcoma displaying arborizing vascular arrangements on cytology smears: a case report of an interesting cytomorphologic pattern in an uncommon tumor. (21053578)
2010
15
Radiological-pathological correlation of pleomorphic liposarcoma of the anterior mediastinum in a 17-year-old girl. (20827472)
2010
16
Primary pleomorphic liposarcoma: a rare mediastinal tumor. (20719913)
2010
17
Pleomorphic liposarcoma of the axilla metastatic to the pancreas. (19590203)
2009
18
Overlapping features between dedifferentiated liposarcoma and undifferentiated high-grade pleomorphic sarcoma. (19574885)
2009
19
Analysis of CHOP rearrangement in pleomorphic liposarcomas using fluorescence in situ hybridization. (19037998)
2009
20
Pleomorphic liposarcoma of the pectoralis major muscle in an elderly man: report of a case and review of literature. (20160372)
2009
21
Cytopathological diagnosis of metastatic pleomorphic liposarcoma in the lung: a report of a case correlated with the histopathology of the primary tumour. (19373911)
2009
22
Pleomorphic liposarcoma of the foot: a case report. (18416844)
2008
23
Mediastinal pleomorphic liposarcoma diagnosed by fine needle aspiration biopsy: a case report. (17536551)
2007
24
Pathology quiz case 2. Pleomorphic liposarcoma (PLS) of the retrotonsillar fossa. (17372093)
2007
25
Primary pleomorphic liposarcoma of bone: MRI findings and review of the literature. (16175410)
2006
26
Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances. (15702084)
2005
27
Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript. (15720420)
2005
28
Primary pleomorphic liposarcoma of the parotid gland: a case report and review of the literature. (15547814)
2004
29
Pleomorphic liposarcoma in a ten year old child. (15552292)
2004
30
Epithelioid variant of pleomorphic liposarcoma: report of a case. (15462502)
2004
31
Primary purely intradermal pleomorphic liposarcoma. (12950504)
2003
32
Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group. (11979090)
2002
33
Fine needle aspiration of pleomorphic liposarcoma of the breast: revised diagnosis. (11726108)
2001
34
Pleomorphic liposarcoma: a clinicopathologic analysis of 19 cases. (11266523)
2001
35
Pleomorphic liposarcoma of a young woman following radiotherapy for epithelioid sarcoma. (11173662)
2000
36
Fibrohistiocytic differentiation in subcutaneous fatty tumors. Study of spindle cell, pleomorphic, myxoid, and atypical lipoma and dedifferentiated liposarcoma cases composed in part of CD34+ fibroblasts and FXIIIa+ histiocytes. (9331894)
1997
37
Mesenteric pleomorphic liposarcoma in an adolescent. (9126049)
1997
38
A pleomorphic liposarcoma imitated a subcutaneous cyst. (9394990)
1997
39
Pleomorphic liposarcoma of the pterygomandibular space involving the maxilla. (7614211)
1995
40
Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. (7977944)
1994
41
Physical mapping of chromosome 12q breakpoints in lipoma, pleomorphic salivary gland adenoma, uterine leiomyoma, and myxoid liposarcoma. (8020967)
1994
42
Case report 637. Mixed type liposarcoma with myxoid and pleomorphic patterns. (2255956)
1990
43
Ultrastructural characteristics of a pleomorphic liposarcoma. A possible involvement of myofibroblast. (3630699)
1987
44
Pleomorphic liposarcoma in an aged rat. (3712904)
1986
45
Pleomorphic lipoma: a tumour simulating liposarcoma. (6884998)
1983
46
Pleomorphic liposarcoma following radiotherapy for breast carcinoma. (7059926)
1982
47
Case report 172: pleomorphic liposarcoma, grade IV, of the soft tissue, arising in generalized plexiform neurofibromatosis. (6800037)
1981
48
Pleomorphic lipoma: a benign tumor simulating liposarcoma. A clinicopathologic analysis of 48 cases. (7459800)
1981
49
Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. (223963)
1979
50
Primary pleomorphic liposarcoma of the larynx. (650725)
1978

Genetic Variations for Pleomorphic Liposarcoma

Expression for genes affiliated with Pleomorphic Liposarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleomorphic Liposarcoma

Search GEO for disease gene expression data for Pleomorphic Liposarcoma.

Pathways for genes affiliated with Pleomorphic Liposarcoma

Sources:
38NCBI BioSystems Database
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Pathways related to Pleomorphic Liposarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4DLGAP5, MDM2

Compounds for genes affiliated with Pleomorphic Liposarcoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Pleomorphic Liposarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1roscovitine459.3MDM2, VIM
2mucicarmine459.1VIM, CALB2
3b 723459.1CALB2, VIM
4hematoxylin458.9INHA, CALB2, VIM
5estradiol45 11 2410.7INHA, MDM2, VIM
6paclitaxel45 50 1110.5MDM2, CALB2, VIM
7paraffin458.3INHA, MDM2, CALB2, VIM
8progesterone45 60 29 11 2412.3VIM, CALB2, MDM2, INHA
9testosterone45 60 11 2411.3INHA, MDM2, CALB2, VIM
10estrogen458.0VIM, CALB2, MDM2, INHA

GO Terms for genes affiliated with Pleomorphic Liposarcoma

Sources:
16Gene Ontology
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Molecular functions related to Pleomorphic Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.0MDM2, VIM
2identical protein bindingGO:0428028.9FUS, MDM2, VIM

Products for genes affiliated with Pleomorphic Liposarcoma

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Sources for Pleomorphic Liposarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet