PLS
MCID: PLM019
MIFTS: 45

Pleomorphic Liposarcoma (PLS) malady

Cancer diseases category

Summaries for Pleomorphic Liposarcoma

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MalaCards: Pleomorphic Liposarcoma, also known as liposarcoma, pleomorphic, is related to liposarcoma and sarcoma, and has symptoms including soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma, lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer and subcutaneous nodules/lipomas/tumefaction/swelling. An important gene associated with Pleomorphic Liposarcoma is INHA (inhibin, alpha), and among its related pathways is Aurora A signaling. The compounds roscovitine and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and bone, and related mouse phenotypes are reproductive system and behavior/neurological.

Aliases & Classifications for Pleomorphic Liposarcoma

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60UMLS, 8Disease Ontology, 48Orphanet, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
pleomorphic liposarcoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

pleomorphic liposarcoma 8 48
liposarcoma, pleomorphic 60
papillon-lefevre disease 60
liposarcoma pleomorphic 44
pls 48


External Ids:

Disease Ontology8 DOID:5702
NCIt39 C3705
MeSH34 D008080
ICD10 via Orphanet26 C49
SNOMED-CT via Orphanet57 112683004, 404071006
UMLS via Orphanet61 C0205825

Related Diseases for Pleomorphic Liposarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Pleomorphic Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma31.4FUS, MDM2, CALB2, VIM
2sarcoma30.4FUS, MDM2, CALB2, VIM
3fibrous histiocytoma30.3VIM, FUS
4myxoid liposarcoma30.3MDM2, FUS
5epithelioid sarcoma30.1CALB2, VIM
6rhabdomyosarcoma30.1INHA, MDM2, CALB2, VIM
7papillon-lefevre disease10.7
8breast liposarcoma10.4
9liposarcoma of bone10.3
10myocardial infarction10.3
11lateral sclerosis10.3
12clear cell acanthoma10.3
13juvenile primary lateral sclerosis10.3
14pleomorphic carcinoma10.2
15cutaneous liposarcoma10.2
16histiocytoma10.2
17mediastinitis10.2
18lymphogranuloma venereum10.1
19encephalomyelitis10.1
20neurofibromatosis10.1
21muir-torre syndrome10.1
22larynx liposarcoma10.1
23pediatric liposarcoma10.1
24mediastinum liposarcoma10.1
25intracranial liposarcoma10.1
26adenocarcinoma10.1
27hepatitis10.1
28malignant mesenchymoma10.1
29melanoma10.1
30mesenchymoma10.1
31osteosarcoma10.1
32pleomorphic rhabdomyosarcoma10.1
33prostate adenocarcinoma10.1
34prostatitis10.1
35thyroiditis10.1
36stroke, ischemic10.0
37coronary artery disease10.0
38acute myocardial infarction10.0
39atherosclerosis10.0
40heart cancer10.0
41ischemic heart disease10.0
42cystadenoma10.0INHA
43malignant peritoneal mesothelioma10.0CALB2
44thymus cancer10.0CALB2
45hemangioblastoma10.0INHA
46sertoli-leydig cell tumor10.0CALB2, INHA
47leydig cell tumor10.0CALB2, INHA
48adenofibroma10.0CALB2, INHA
49seminoma10.0INHA, CALB2
50giant cell glioblastoma10.0MDM2

Graphical network of the top 20 diseases related to Pleomorphic Liposarcoma:



Diseases related to pleomorphic liposarcoma

Clinical Features for Pleomorphic Liposarcoma

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48Orphanet
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Symptoms:

48
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • early death/lethality

Drugs & Therapeutics for Pleomorphic Liposarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pleomorphic Liposarcoma

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Liposarcoma

Search NIH Clinical Center for Pleomorphic Liposarcoma

Search CenterWatch for Pleomorphic Liposarcoma

Genetic Tests for Pleomorphic Liposarcoma

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Anatomical Context for Pleomorphic Liposarcoma

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32MalaCards
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MalaCards organs/tissues related to Pleomorphic Liposarcoma:

32
Lung, Breast, Bone, Liver, Salivary gland, Pancreas, Smooth muscle, Thyroid, Uterus, Prostate, Tongue

Animal Models for Pleomorphic Liposarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pleomorphic Liposarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.7FUS, DLGAP5, INHA, MDM2, VIM
2MP:00053867.6CALB2, MDM2, PRRX1, FUS, VIM

Publications for Pleomorphic Liposarcoma

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50PubMed
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Articles related to Pleomorphic Liposarcoma:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Pleomorphic lipoma of the tongue as potential mimic of liposarcoma. (23723609)
2013
2
Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature. (23651098)
2013
3
Muir-Torre syndrome-associated pleomorphic liposarcoma arising in a previous radiation field. (23299928)
2013
4
Dedifferentiated liposarcoma and pleomorphic liposarcoma: A comparative study of cytomorphology and MDM2/CDK4 expression on fine-needle aspiration. (24227706)
2013
5
Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. (22472959)
2012
6
Primary pleomorphic liposarcoma of the orbit: a case report. (22551368)
2012
7
Combined cutaneous sarcoma: pleomorphic liposarcoma and conventional osteosarcoma-the so-called malignant mesenchymoma. (23082265)
2012
8
Primary orbital pleomorphic liposarcoma: an aggressive course. (22460675)
2012
9
Metachronous pleomorphic liposarcoma and melanoma: a rare case report. (21393919)
2011
10
Prostatic adenocarcinoma metastatic to pleomorphic liposarcoma, a "collision phenomenon": report of a case with review of pelvic collision tumors. (21904691)
2011
11
Epithelioid variant of pleomorphic liposarcoma as potential mimic of metastatic carcinoma. (21464872)
2011
12
Pleomorphic liposarcoma originating from intracranial dura mater. (19727564)
2010
13
Metastasis after resection of huge primary pericardial pleomorphic liposarcoma with cardiopulmonary bypass. (20333575)
2010
14
Epithelioid variant of a pleomorphic liposarcoma displaying arborizing vascular arrangements on cytology smears: a case report of an interesting cytomorphologic pattern in an uncommon tumor. (21053578)
2010
15
Radiological-pathological correlation of pleomorphic liposarcoma of the anterior mediastinum in a 17-year-old girl. (20827472)
2010
16
Pleomorphic liposarcoma of the axilla metastatic to the pancreas. (19590203)
2009
17
Pleomorphic liposarcoma of the pectoralis major muscle in an elderly man: report of a case and review of literature. (20160372)
2009
18
Cytopathological diagnosis of metastatic pleomorphic liposarcoma in the lung: a report of a case correlated with the histopathology of the primary tumour. (19373911)
2009
19
Pleomorphic liposarcoma of the foot: a case report. (18416844)
2008
20
Primary pleomorphic liposarcoma of the liver in a dog. (19227140)
2008
21
Pathology quiz case 2. Pleomorphic liposarcoma (PLS) of the retrotonsillar fossa. (17372093)
2007
22
Giant ulcerated pleomorphic liposarcoma of the chest wall. (18090587)
2007
23
Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances. (15702084)
2005
24
Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript. (15720420)
2005
25
Primary pleomorphic liposarcoma of the parotid gland: a case report and review of the literature. (15547814)
2004
26
Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. (15371941)
2004
27
Epithelioid variant of pleomorphic liposarcoma: report of a case. (15462502)
2004
28
Primary purely intradermal pleomorphic liposarcoma. (12950504)
2003
29
Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group. (11979090)
2002
30
Pleomorphic liposarcoma. (11757868)
2001
31
Fine needle aspiration of pleomorphic liposarcoma of the breast: revised diagnosis. (11726108)
2001
32
Pleomorphic liposarcoma: a clinicopathologic analysis of 19 cases. (11266523)
2001
33
Pleomorphic liposarcoma of a young woman following radiotherapy for epithelioid sarcoma. (11173662)
2000
34
Epithelioid variant of pleomorphic liposarcoma: a study of 12 cases of a distinctive variant of high-grade liposarcoma. (10430277)
1999
35
Fine needle aspiration of primary pleomorphic liposarcoma of the breast. A case report. (10578991)
1999
36
Fibrohistiocytic differentiation in subcutaneous fatty tumors. Study of spindle cell, pleomorphic, myxoid, and atypical lipoma and dedifferentiated liposarcoma cases composed in part of CD34+ fibroblasts and FXIIIa+ histiocytes. (9331894)
1997
37
Mesenteric pleomorphic liposarcoma in an adolescent. (9126049)
1997
38
A pleomorphic liposarcoma imitated a subcutaneous cyst. (9394990)
1997
39
Pleomorphic liposarcoma of the pterygomandibular space involving the maxilla. (7614211)
1995
40
Physical mapping of chromosome 12q breakpoints in lipoma, pleomorphic salivary gland adenoma, uterine leiomyoma, and myxoid liposarcoma. (8020967)
1994
41
The 12q13-q15 translocation breakpoints in pleomorphic adenoma and clear-cell sarcoma of tendons and aponeuroses are different from that in myxoid liposarcoma. (7687873)
1993
42
Well-differentiated liposarcoma mimicking a pleomorphic lipoma--a case report. (8491861)
1993
43
Case report 637. Mixed type liposarcoma with myxoid and pleomorphic patterns. (2255956)
1990
44
Pleomorphic liposarcoma in an aged rat. (3712904)
1986
45
Pleomorphic lipoma: a tumour simulating liposarcoma. (6884998)
1983
46
Pleomorphic liposarcoma following radiotherapy for breast carcinoma. (7059926)
1982
47
Case report 172: pleomorphic liposarcoma, grade IV, of the soft tissue, arising in generalized plexiform neurofibromatosis. (6800037)
1981
48
Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. (223963)
1979
49
Primary pleomorphic liposarcoma of the larynx. (650725)
1978
50
Ultrastructural observations in pleomorphic liposarcoma. (212174)
1978

Genetic Variations for Pleomorphic Liposarcoma

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Expression for genes affiliated with Pleomorphic Liposarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleomorphic Liposarcoma

Search GEO for disease gene expression data for Pleomorphic Liposarcoma.

Pathways for genes affiliated with Pleomorphic Liposarcoma

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37NCBI BioSystems Database
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Pathways related to Pleomorphic Liposarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4DLGAP5, MDM2

Compounds for genes affiliated with Pleomorphic Liposarcoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Pleomorphic Liposarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1roscovitine449.3MDM2, VIM
2mucicarmine449.1VIM, CALB2
3b 723449.1CALB2, VIM
4hematoxylin448.9INHA, CALB2, VIM
5estradiol44 11 2410.7INHA, MDM2, VIM
6paclitaxel44 49 1110.5MDM2, CALB2, VIM
7paraffin448.3INHA, MDM2, CALB2, VIM
8progesterone44 59 28 11 2412.3VIM, CALB2, MDM2, INHA
9testosterone44 59 11 2411.3INHA, MDM2, CALB2, VIM
10estrogen448.0VIM, CALB2, MDM2, INHA

GO Terms for genes affiliated with Pleomorphic Liposarcoma

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16Gene Ontology
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Molecular functions related to Pleomorphic Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.0MDM2, VIM
2identical protein bindingGO:0428028.9FUS, MDM2, VIM

Products for genes affiliated with Pleomorphic Liposarcoma

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Sources for Pleomorphic Liposarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet