MCID: PLM030
MIFTS: 49

Pleomorphic Rhabdomyosarcoma malady

Cancer diseases, Rare diseases categories

Summaries for Pleomorphic Rhabdomyosarcoma

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MalaCards based summary: Pleomorphic Rhabdomyosarcoma, also known as anaplastic rhabdomyosarcoma, is related to rhabdomyosarcoma and colorectal cancer. An important gene associated with Pleomorphic Rhabdomyosarcoma is MYH3 (myosin, heavy chain 3, skeletal muscle, embryonic), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Oncogene Induced Senescence. The compounds olomoucine and sodium nitroprusside have been mentioned in the context of this disorder. Affiliated tissues include uterus, heart and skeletal muscle, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Aliases & Classifications for Pleomorphic Rhabdomyosarcoma

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Sources:
10Disease Ontology, 49Orphanet, 62UMLS, 57SNOMED-CT, 40NCIt, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Pleomorphic Rhabdomyosarcoma, Aliases & Descriptions:

Name: Pleomorphic Rhabdomyosarcoma 10 49 62
Anaplastic Rhabdomyosarcoma 10 62
 
Pleomorphic Rhabdomyosarcoma, Adult Type 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 49 
Rare tumors


Characteristics (Orphanet epidemiological data):

49
pleomorphic rhabdomyosarcoma:
Prevalence: <1/1000000 (Europe)


External Ids:

Disease Ontology10 DOID:3250
NCIt40 C4258
Orphanet49 293199
SNOMED-CT57 77455004, 404054005
ICD10 via Orphanet28 C49.9
UMLS via Orphanet63 C0334480

Related Diseases for Pleomorphic Rhabdomyosarcoma

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Diseases in the Pleomorphic Rhabdomyosarcoma family:

Adult Pleomorphic Rhabdomyosarcoma

Diseases related to Pleomorphic Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma31.6DES, TP53, PAX7, MYOD1, MYOG, MB
2colorectal cancer30.4TP53, EPHA3, MAPK3
3liposarcoma30.2MB, TP53, DES
4melanoma30.0DES, TP53, PAX7, EPHA3, MYOD1, MME
5adult pleomorphic rhabdomyosarcoma10.4
6laryngitis10.4
7childhood pleomorphic rhabdomyosarcoma10.3
8thrombocytopenia10.1
9choledochal cyst10.1
10obstructive jaundice10.1
11fibrous histiocytoma10.1
12pleomorphic liposarcoma10.1
13botryoid rhabdomyosarcoma10.1
14histiocytoma10.1
15mediastinitis10.1
16pulmonary embolism10.1
17cytomegalovirus infection10.1
18malignant mesenchymoma10.0MYOD1, MYOG
19myoma10.0DES, MYOG
20pseudosarcomatous fibromatosis10.0MYOG, DES
21alveolar soft-part sarcoma10.0MYOD1, MB
22myositis10.0MB, MYOD1
23rhabdoid tumor10.0MYOD1, DES
24myopathy congenital10.0MYOG, DES
25granular cell tumor10.0DES, MB
26adenofibroma10.0MUC16
27endometrial stromal sarcoma10.0DES, MME
28embryonal cancer10.0MYOD1, MYOG, ALPPL2
29smooth muscle tumor10.0MME, DES
30malignant fibroxanthoma10.0TP53, MB
31neuropathy10.0MB, MYOG, MYOD1
32duchenne muscular dystrophy10.0MB, MYOD1, DES
33leiomyoma10.0DES, MYOG, MME
34neuromuscular disease10.0MB, DES
35endodermal sinus tumor10.0ALPPL2, MUC16
36uterine sarcoma10.0MB, MME, DES
37adenosarcoma10.0DES, MME, MB
38peripheral primitive neuroectodermal tumor10.0MYOG, MYOD1, PAX7, DES
39malignant mixed mullerian tumor10.0MB, TP53, DES
40fibroma10.0MUC16, DES
41myotonic dystrophy10.0MYOG, MYOD1
42cholangiocarcinoma10.0TP53, MME, ALPPL2
43wilms tumor10.0MME, MYOG, MYOD1, DES
44abrikosov's tumor10.0DES, MUC16
45uterine fibroid10.0DES, MYOG, MUC16
46medulloblastoma10.0DES, TP53, MAPK3
47factor vii deficiency10.0MB, MUC16
48lung benign neoplasm10.0MAPK3, MME, TP53
49b-cell lymphomas10.0MAPK3, MME, TP53
50rhabdomyosarcoma 2, alveolar10.0DES, PAX7, MYOD1, MYOG, MB

Graphical network of the top 20 diseases related to Pleomorphic Rhabdomyosarcoma:



Diseases related to pleomorphic rhabdomyosarcoma

Symptoms for Pleomorphic Rhabdomyosarcoma

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Drugs & Therapeutics for Pleomorphic Rhabdomyosarcoma

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Drug clinical trials:

Search ClinicalTrials for Pleomorphic Rhabdomyosarcoma

Search NIH Clinical Center for Pleomorphic Rhabdomyosarcoma

Genetic Tests for Pleomorphic Rhabdomyosarcoma

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Anatomical Context for Pleomorphic Rhabdomyosarcoma

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MalaCards organs/tissues related to Pleomorphic Rhabdomyosarcoma:

33
Uterus, Heart, Skeletal muscle, Kidney, Bone, Smooth muscle, Liver, Salivary gland, Adrenal gland, Breast, Skin

Animal Models for Pleomorphic Rhabdomyosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Rhabdomyosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7MAPK3, MYOD1, PAX7, TP53
2MP:00053857.9DES, TP53, EPHA3, MYOD1, MAPK3, MB
3MP:00053867.8DES, TP53, PAX7, EPHA3, MYOG, MAPK3
4MP:00053697.7DES, TP53, PAX7, MYOD1, MYOG, MAPK3
5MP:00053887.6MB, TP53, PAX7, EPHA3, MYOD1, MYOG
6MP:00053767.2DES, TP53, EPHA3, MYOD1, MYOG, MME
7MP:00107687.2DES, TP53, PAX7, EPHA3, MYOD1, MYOG

Publications for Pleomorphic Rhabdomyosarcoma

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Articles related to Pleomorphic Rhabdomyosarcoma:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Pelvic pleomorphic rhabdomyosarcoma presenting as oliguria in a 61-year-old woman. (25880675)
2015
2
Cutaneous Pleomorphic Rhabdomyosarcoma Occurring on Sun Damaged Skin: A Case Report. (25140666)
2014
3
Pleomorphic rhabdomyosarcoma of the cerebellopontine angle in an adult: a review of literature. (24481021)
2014
4
Pleomorphic rhabdomyosarcoma in a patient with hereditary nonpolyposis colorectal cancer. (23319697)
2013
5
A pleomorphic rhabdomyosarcoma mimicking an inguinal hernia: a case report and review of the literature. (22611365)
2012
6
Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. (23002204)
2012
7
Pleomorphic rhabdomyosarcoma with pulmonary tumour embolism. (23203178)
2012
8
Multiple sites of highly amplified DNA sequences detected by molecular cytogenetic analysis in HS-RMS-2, a new pleomorphic rhabdomyosarcoma cell line. (22432055)
2012
9
Uterine pleomorphic rhabdomyosarcoma: a case report and review of literature. (21476391)
2011
10
Touch preparation of primary uterine pleomorphic rhabdomyosarcoma: report of a case with clinical cytopathologic features. (21053592)
2010
11
A rare case of paratesticular pleomorphic rhabdomyosarcoma diagnosed by fine needle aspiration: a case report. (19790247)
2010
12
Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. (20173498)
2010
13
Pleomorphic rhabdomyosarcoma of the uterine corpus--a case report. (20825058)
2010
14
Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma. (19480930)
2009
15
Primary pleomorphic rhabdomyosarcoma of trunk in an adolescent. (19317765)
2009
16
A rare tumor of the diaphragm: pleomorphic rhabdomyosarcoma. (18442596)
2008
17
Primary pleomorphic rhabdomyosarcoma of the kidney in an adult. (18621001)
2008
18
A case of extremely chemoresistant pure pleomorphic rhabdomyosarcoma of the uterus associated with a high serum LDH level. (19051826)
2008
19
Primary mediastinal pleomorphic rhabdomyosarcoma: a case report. (18287801)
2008
20
Laryngeal pleomorphic rhabdomyosarcoma. (17481838)
2007
21
Palpebral pleomorphic rhabdomyosarcoma in a teenager. (16946759)
2007
22
Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. (17630111)
2007
23
Pleomorphic rhabdomyosarcoma within a choledochal cyst; a rare cause of obstructive jaundice. (16967793)
2006
24
Unusual manifestations of disseminated neoplasia at presentation: right-sided heart failure due to a massive cardiac metastasis and autoimmune thrombocytopenia in pleomorphic rhabdomyosarcoma of the adult. (16462513)
2006
25
Botryoid-type pleomorphic rhabdomyosarcoma of the renal pelvis in an adult. A rare case report and review of the literature. (16825824)
2006
26
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal patient. (16799711)
2006
27
Pleomorphic rhabdomyosarcoma of the diaphragm. (15719879)
2005
28
Paratesticular pleomorphic rhabdomyosarcoma in an adult. (15787340)
2004
29
Pleomorphic rhabdomyosarcoma of the anterior abdominal wall following multimodality treatment for carcinoma of the rectum. (15173925)
2004
30
Pleomorphic rhabdomyosarcoma with pulmonary metastasis in a stranded Steller (northern) sea lion (Eumetopias jubatus). (15003477)
2004
31
Primary pleomorphic rhabdomyosarcoma of the kidney in adults: unusual tumor]. (14650305)
2003
32
Microsatellite instability in a pleomorphic rhabdomyosarcoma in a patient with hereditary non-polyposis colorectal cancer. (12940783)
2003
33
Pleomorphic rhabdomyosarcoma in an adult forearm: a case report. (11810631)
2002
34
Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. (11406662)
2001
35
Pleomorphic rhabdomyosarcoma of the uterine corpus: a case report. (11446473)
2001
36
Unusual second malignancies following radiation therapy: subcutaneous pleomorphic rhabdomyosarcoma and cutaneous melanoma. Two case reports. (10955690)
2000
37
A new human pleomorphic rhabdomyosarcoma cell-line, HS-RMS-1, exhibiting MyoD1 and myogenin. (10853028)
2000
38
Uterine pleomorphic rhabdomyosarcoma in a patient receiving tamoxifen therapy. (10600318)
1999
39
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal woman with elevated serum CA125. (10479519)
1999
40
Laryngeal pleomorphic rhabdomyosarcoma. (9693927)
1998
41
A rare paratesticular pleomorphic rhabdomyosarcoma. (7656365)
1995
42
Pleomorphic rhabdomyosarcoma of the heart metastatic to bone. Report of a case with fine needle aspiration biopsy findings. (7762352)
1995
43
Identification of a spontaneous pleomorphic rhabdomyosarcoma in the thoracic and abdominal cavities of a female Wistar rat. (7725603)
1995
44
Pleomorphic rhabdomyosarcoma arising in association with the right pulmonary artery. (7979918)
1994
45
Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. (8333559)
1993
46
Pleomorphic rhabdomyosarcoma of the urinary bladder in association with recurrent urinary-tract infection. (2703059)
1989
47
Rapid remission of a large pleomorphic rhabdomyosarcoma with radiation and a novel schedule of simultaneous high-dose cisplatin. (2623385)
1989
48
Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. (223963)
1979
49
Pleomorphic rhabdomyosarcoma of the larynx. A case report and review of the literature. (956708)
1976
50
Pleomorphic rhabdomyosarcoma of the uvula--report of a case and review of the literature. (4773903)
1973

Variations for Pleomorphic Rhabdomyosarcoma

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Expression for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Search GEO for disease gene expression data for Pleomorphic Rhabdomyosarcoma.

Pathways for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Pathways related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8MAPK3, MME
29.6MAPK3, TP53
39.6MAPK3, TP53
49.6MYOD1, PAX7
59.4MYOD1, TP53
69.3MYOG, MYOD1
7
Show member pathways
9.3MYOD1, MYOG
8
Show member pathways
Alzheimers Disease38
9.3TP53, MME, MAPK3
9
Show member pathways
8.7MAPK3, MYH3, EPHA3, TP53, DES

Compounds for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Compounds related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1olomoucine45 1310.8TP53, MAPK3
2sodium nitroprusside459.8MB, MAPK3, MME
3phorbol 12,13-dibutyrate459.8MAPK3, EPHA3
4b 723459.7MUC16, DES
5hyaluronic acid45 2610.6MB, DES, MUC16
6sp 60012545 6110.6TP53, EPHA3, MAPK3
7resveratrol45 61 26 1312.6MAPK3, EPHA3, TP53
8c2ceramide459.5TP53, MAPK3, MYOG
9adriamycin459.5MME, TP53, DES, MB
10citrate459.5MYOD1, MME, MB
11amifostine45 1310.5ALPPL2, TP53
12geldanamycin45 51 61 1312.4TP53, MAPK3, MYOD1
13radicicol45 61 1311.3MAPK3, TP53
14lactate459.3MB, DES, MUC16, MME
15thymidine45 2610.3DES, MAPK3, MME, TP53
16n acetylcysteine459.3TP53, MAPK3, MB
17ascorbic acid45 2610.3MB, MME, MAPK3, MYOG
18estradiol45 26 1311.2EPHA3, MUC16, DES, MAPK3
19adenylate459.2MME, MB, DES, MYOG
20melphalan45 51 1311.2MUC16, TP53, MAPK3, MB
21actinomycin d459.1MYOD1, DES, TP53, MME
22cisplatin45 51 61 1312.1MB, MAPK3, MUC16, TP53
23progesterone45 30 61 26 1313.1MME, TP53, DES, MUC16
24fatty acid459.0DES, MYOD1, MME, MYOG
25doxorubicin45 51 1311.0TP53, DES, MUC16, MB, MME
26nitric oxide45 26 1310.9EPHA3, MME, MAPK3, MYOG, DES
27acetylcholine45 51 30 26 1312.8MYOD1, DES, MYOG, MB, MME
28bromodeoxyuridine458.8MAPK3, DES, MYOD1, MYOG, MME
2912-o-tetradecanoylphorbol 13-acetate458.8MYOD1, MME, MYOG, DES, MAPK3
30oligonucleotide458.7MYOG, TP53, MYOD1, PAX7
31threonine458.6MAPK3, MYOD1, EPHA3, DES, MUC16
32phosphatidylinositol458.6MYOD1, EPHA3, MME, MAPK3
33cyclic amp45 269.6MYOD1, MAPK3, ALPPL2, DES
34steroid458.6MUC16, MME, MYOG, MYOD1, DES
35leucine458.6MME, MYOD1, ALPPL2, EPHA3
36arginine458.5TP53, MAPK3, MB, MME, DES, MYOD1
37oxygen45 269.4EPHA3, MYOD1, DES, MME, MB, MYOG
38creatinine458.3MB, MME, MUC16, DES, MYOD1, MYOG
39retinoic acid45 269.3MAPK3, MYOD1, MYOG, MME, TP53, DES
40h2o2458.2MME, MUC16, MAPK3, EPHA3, MB, DES
41glucose458.2MYOG, MYOD1, MUC16, MME, EPHA3, DES
42butyrate458.1MYOG, ALPPL2, MAPK3, MYOD1, TP53
43calcium45 51 26 1311.1DES, MAPK3, MYOD1, MME, MYOG, EPHA3
44cysteine458.0MYOD1, MME, MB, MAPK3, MYOG, EPHA3
45tyrosine457.8MAPK3, MME, MUC16, MYOD1, EPHA3, DES
46testosterone45 61 26 1310.5MYOD1, MYOG, EPHA3, DES, MB, MME
47estrogen457.4TP53, EPHA3, MYOG, MUC16, MME, MAPK3
48vegf457.1TP53, MYOG, DES, EPHA3, MYOD1, MUC16
49serine457.1MB, DES, MME, MYOG, MYOD1, EPHA3
50paraffin457.0ALPPL2, MME, MUC16, MYOG, MYOD1, DES

GO Terms for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Biological processes related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:00903999.9MME, TP53
2muscle filament slidingGO:00300499.8MYH3, DES
3sensory perception of painGO:00192339.8MAPK3, MME
4positive regulation of cell cycle arrestGO:00711589.6TP53, MYOG
5muscle cell fate commitmentGO:00426939.6MYOD1, MYOG
6skeletal muscle fiber developmentGO:00487419.5MYOG, MYOD1
7cellular response to estradiol stimulusGO:00713929.5MYOD1, MYOG
8positive regulation of muscle cell differentiationGO:00511499.4MYOG, MYOD1
9muscle cell differentiationGO:00426929.3MYOD1, MYOG
10skeletal muscle tissue developmentGO:00075199.0MYOD1, MYOG
11positive regulation of transcription from RNA polymerase II promoterGO:00459448.4MYOD1, TP53, PAX7, MYOG, MAPK3

Molecular functions related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:00012289.5MYOG, TP53
2core promoter bindingGO:00010479.3MYOG, MYOD1
3chromatin DNA bindingGO:00314909.2MYOG, MYOD1
4E-box bindingGO:00708889.0MYOG, MYOD1

Products for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Sources for Pleomorphic Rhabdomyosarcoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet