MCID: PLM030
MIFTS: 37

Pleomorphic Rhabdomyosarcoma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Pleomorphic Rhabdomyosarcoma

Aliases & Descriptions for Pleomorphic Rhabdomyosarcoma:

Name: Pleomorphic Rhabdomyosarcoma 12 56 14 69
Adult Pleomorphic Rhabdomyosarcoma 12 14 69
Pleomorphic Rhabdomyosarcoma, Adult Type 12
Anaplastic Rhabdomyosarcoma 12

Characteristics:

Orphanet epidemiological data:

56
pleomorphic rhabdomyosarcoma
Prevalence: <1/1000000 (Europe);

Classifications:



External Ids:

Disease Ontology 12 DOID:3250 DOID:8251
NCIt 47 C4258 C27369
SNOMED-CT 64 404054005 77455004
Orphanet 56 ORPHA293199
UMLS via Orphanet 70 C0334480
ICD10 via Orphanet 34 C49.9

Summaries for Pleomorphic Rhabdomyosarcoma

MalaCards based summary : Pleomorphic Rhabdomyosarcoma, also known as adult pleomorphic rhabdomyosarcoma, is related to childhood pleomorphic rhabdomyosarcoma and rhabdomyosarcoma. An important gene associated with Pleomorphic Rhabdomyosarcoma is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Neural Crest Differentiation and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Vincristine and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include uterus, heart and kidney, and related phenotypes are muscle and respiratory system

Related Diseases for Pleomorphic Rhabdomyosarcoma

Diseases related to Pleomorphic Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Related Disease Score Top Affiliating Genes
1 childhood pleomorphic rhabdomyosarcoma 11.9
2 rhabdomyosarcoma 10.7
3 ectopic pregnancy 10.2 DES MYOD1
4 testis sarcoma 10.2 DES MYOD1
5 cardiac tamponade 10.2 DES MYOD1
6 extraosseous osteosarcoma 10.2 DES MYOD1
7 glaucoma iridogoniodysgenesia 10.1 DES MB
8 small intestinal vasoactive intestinal peptide producing tumor 10.1 DES MME
9 reticulohistiocytic granuloma 10.1 DES MB
10 extracutaneous mastocytoma 10.1 DES MB
11 liver angiosarcoma 10.1 DES MME
12 bone deterioration disease 10.1 DES MB
13 sebaceous adenoma 10.1 DES MME
14 lung benign neoplasm 10.1 DES MYOD1
15 enchondromatosis dwarfism deafness 10.1 DES MYOD1
16 t-cell childhood lymphoblastic lymphoma 10.1 DES MB
17 brain stem infarction 10.1 MB MYOD1
18 pilar sheath acanthoma 10.1 DES MME
19 breast rhabdomyosarcoma 10.1 DES PAX3
20 endodermal sinus tumor 10.1 MB MYOD1
21 glomerulonephritis 10.1 MB MYOD1
22 juvenile xanthogranuloma 10.1 DES MYOD1
23 diabetes persistent mullerian ducts 10.1 DES MYOD1
24 hyperpituitarism 10.1 DES MB
25 nodular tenosynovitis 10.1 MME MYOD1
26 arthus reaction 10.1 MB MME
27 pulmonary immaturity 10.0 MB MYOD1
28 palmoplantar keratosis 10.0 DES MB
29 black piedra 10.0 DES MME
30 mixed type rhabdomyosarcoma 10.0 DES MB MYOD1
31 verruciform xanthoma of skin 10.0 DES MB MYOD1
32 intrahepatic bile duct cystadenoma 10.0 DES MB MYOD1
33 transitional cell carcinoma 10.0 DES MB MYOD1
34 ovarian cystadenoma 10.0 DES MB MYOD1
35 childhood medulloblastoma 10.0 DES MB MYOD1
36 advanced sleep-phase syndrome, familial, 2 10.0 DES MB MYOD1
37 adenosarcoma 10.0 DES MB
38 rectal neoplasm 10.0 DES MB MME
39 van regemorter pierquin vamos syndrome 10.0 DES MB MME
40 extraosseous ewing's sarcoma 9.9 DES MB MME
41 laryngitis 9.9
42 cerebral angioma 9.9 MB MYOD1
43 colorectal cancer 9.8
44 myoblastoma 9.8 MYOD1 PAX3 PAX7
45 spindle cell rhabdomyosarcoma 9.7 DES MB MYOD1 PAX3
46 histiocytoma 9.7
47 fibrous histiocytoma 9.7
48 pancreatitis 9.7
49 pleomorphic liposarcoma 9.7
50 thyroiditis 9.7

Graphical network of the top 20 diseases related to Pleomorphic Rhabdomyosarcoma:



Diseases related to Pleomorphic Rhabdomyosarcoma

Symptoms & Phenotypes for Pleomorphic Rhabdomyosarcoma

MGI Mouse Phenotypes related to Pleomorphic Rhabdomyosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.35 DES MB MYOD1 PAX3 PAX7
2 respiratory system MP:0005388 8.92 MB MYOD1 PAX3 PAX7

Drugs & Therapeutics for Pleomorphic Rhabdomyosarcoma

Drugs for Pleomorphic Rhabdomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
2
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
3
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
4
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
5
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
6
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
7
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
8
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
9
Cyproheptadine Approved Phase 3 129-03-3 2913
10 Alkylating Agents Phase 3,Phase 2
11 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
12 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
13 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
14 Etoposide phosphate Phase 3,Phase 2
15 Anti-Infective Agents Phase 3,Phase 2
16 Immunosuppressive Agents Phase 3,Phase 2
17 Isophosphamide mustard Phase 3,Phase 2
18 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
19 Antimitotic Agents Phase 3,Phase 2
20 Antirheumatic Agents Phase 3,Phase 2
21 Antineoplastic Agents, Alkylating Phase 3,Phase 2
22 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
23
Histamine Phosphate Phase 3 51-74-1 65513
24
Serotonin Phase 3 50-67-9 5202
25 Serotonin Agents Phase 3
26 Serotonin Antagonists Phase 3
27 Gastrointestinal Agents Phase 3
28 Neurotransmitter Agents Phase 3
29 Histamine Antagonists Phase 3
30 Histamine H1 Antagonists Phase 3
31 Dermatologic Agents Phase 3
32 Anti-Allergic Agents Phase 3
33 Antipruritics Phase 3
34
Doxorubicin Approved, Investigational Phase 2,Phase 1 23214-92-8 31703
35
Vinblastine Approved Phase 2 865-21-4 13342 241903
36
Vinorelbine Approved, Investigational Phase 2 71486-22-1 60780 44424639
37
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
38
Everolimus Approved Phase 2 159351-69-6 6442177
39
Lenograstim Approved Phase 2 135968-09-1
40
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
41
Bevacizumab Approved, Investigational Phase 2 216974-75-3
42
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
43
Gemcitabine Approved Phase 2 95058-81-4 60750
44
Doxil Approved June 1999 Phase 2,Phase 1 31703
45 Imatinib Mesylate Phase 2 123596
46 Mitogens Phase 2
47 Angiogenesis Inhibitors Phase 2
48 Angiogenesis Modulating Agents Phase 2
49 Endothelial Growth Factors Phase 2
50 Immunoglobulin G Phase 2

Interventional clinical trials:

(show all 11)
id Name Status NCT ID Phase
1 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3
2 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
3 Vinorelbine Tartrate and Cyclophosphamide in Combination With Bevacizumab or Temsirolimus in Treating Patients With Recurrent or Refractory Rhabdomyosarcoma Completed NCT01222715 Phase 2
4 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2
5 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2
6 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2
7 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2
8 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2
9 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1
10 Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery Recruiting NCT03009201 Phase 1
11 DNA Tests in Detecting Disseminated Disease in Tumor, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma Completed NCT01419509

Search NIH Clinical Center for Pleomorphic Rhabdomyosarcoma

Genetic Tests for Pleomorphic Rhabdomyosarcoma

Anatomical Context for Pleomorphic Rhabdomyosarcoma

MalaCards organs/tissues related to Pleomorphic Rhabdomyosarcoma:

39
Uterus, Heart, Kidney, Skeletal Muscle, Skin, Breast, Adrenal Gland

Publications for Pleomorphic Rhabdomyosarcoma

Articles related to Pleomorphic Rhabdomyosarcoma:

(show top 50) (show all 86)
id Title Authors Year
1
Pleomorphic rhabdomyosarcoma arising in the anterior mediastinum: A case report with cytological features of imprint and liquid-based cytology specimens. ( 28024111 )
2016
2
Misdiagnosis of primary pleomorphic rhabdomyosarcoma of the right thigh in a young adult: A case report. ( 27588141 )
2016
3
Pleomorphic rhabdomyosarcoma of the left atrium mimicking myxoma. ( 27510683 )
2016
4
Primary Pleomorphic Rhabdomyosarcoma of Thyroid Gland in an Adult Patient: A Case Report. ( 27026769 )
2016
5
Pleomorphic rhabdomyosarcoma with an impressive response to chemotherapy: case report and review of the literature. ( 26952562 )
2016
6
Pleomorphic Rhabdomyosarcoma Arising from True Vocal Fold of Larynx: Report of a Rare Case and Literature Review. ( 27699075 )
2016
7
Case of pleomorphic rhabdomyosarcoma arising on subcutaneous tissue in an adult patient: Review of the published works of 13 cases arising on cutaneous or subcutaneous tissue. ( 27569112 )
2016
8
Rapidly growing massive pleomorphic rhabdomyosarcoma of the bladder presenting with bladder outlet obstruction. ( 26381078 )
2015
9
Adult Pleomorphic Rhabdomyosarcoma: A Multicentre Retrospective Study. ( 26504053 )
2015
10
Pancreatic pleomorphic rhabdomyosarcoma. ( 26092712 )
2015
11
Pelvic pleomorphic rhabdomyosarcoma presenting as oliguria in a 61-year-old woman. ( 25880675 )
2015
12
Adult Duodenal Pleomorphic Rhabdomyosarcoma. ( 26157890 )
2014
13
Pleomorphic Rhabdomyosarcoma Presenting as a Hypopharyngeal Mass. ( 25243978 )
2014
14
Primary pleomorphic rhabdomyosarcoma of breast: Report of a rare neoplasm. ( 25709664 )
2014
15
Primary pleomorphic rhabdomyosarcoma of the adrenal gland in an adult: A case report. ( 24348835 )
2014
16
Pleomorphic rhabdomyosarcoma of the cerebellopontine angle in an adult: a review of literature. ( 24481021 )
2014
17
Cutaneous Pleomorphic Rhabdomyosarcoma Occurring on Sun Damaged Skin: A Case Report. ( 25140666 )
2014
18
Pleomorphic rhabdomyosarcoma in a patient with hereditary nonpolyposis colorectal cancer. ( 23319697 )
2013
19
Paratesticular pleomorphic rhabdomyosarcoma: a report of two cases. ( 23476881 )
2013
20
Postradiation cutaneous pleomorphic rhabdomyosarcoma with extracellular collagen deposits reminiscent of so-called amianthoid fibers. ( 24341853 )
2013
21
Multiple sites of highly amplified DNA sequences detected by molecular cytogenetic analysis in HS-RMS-2, a new pleomorphic rhabdomyosarcoma cell line. ( 22432055 )
2012
22
Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. ( 23002204 )
2012
23
Pleomorphic rhabdomyosarcoma with pulmonary tumour embolism. ( 23203178 )
2012
24
A pleomorphic rhabdomyosarcoma mimicking an inguinal hernia: a case report and review of the literature. ( 22611365 )
2012
25
Uterine pleomorphic rhabdomyosarcoma: a case report and review of literature. ( 21476391 )
2011
26
p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma. ( 20662002 )
2010
27
Pleomorphic rhabdomyosarcoma of the uterine corpus--a case report. ( 20825058 )
2010
28
Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. ( 20173498 )
2010
29
Touch preparation of primary uterine pleomorphic rhabdomyosarcoma: report of a case with clinical cytopathologic features. ( 21053592 )
2010
30
Electrochemotherapy treatment for bilateral pleomorphic rhabdomyosarcoma in a cat. ( 20492454 )
2010
31
Pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation: a single case report. ( 20070153 )
2010
32
A rare case of paratesticular pleomorphic rhabdomyosarcoma diagnosed by fine needle aspiration: a case report. ( 19790247 )
2010
33
Pleomorphic rhabdomyosarcoma pulmonary embolism. ( 19713348 )
2009
34
Primary pleomorphic rhabdomyosarcoma of trunk in an adolescent. ( 19317765 )
2009
35
Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma. ( 19480930 )
2009
36
Surgical management of an inoperable giant pleomorphic rhabdomyosarcoma of the chest wall. ( 19704344 )
2009
37
Primary pleomorphic rhabdomyosarcoma of the kidney in an adult. ( 18621001 )
2008
38
A case of extremely chemoresistant pure pleomorphic rhabdomyosarcoma of the uterus associated with a high serum LDH level. ( 19051826 )
2008
39
A rare tumor of the diaphragm: pleomorphic rhabdomyosarcoma. ( 18442596 )
2008
40
Primary mediastinal pleomorphic rhabdomyosarcoma: a case report. ( 18287801 )
2008
41
Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. ( 17630111 )
2007
42
Palpebral pleomorphic rhabdomyosarcoma in a teenager. ( 16946759 )
2007
43
Laryngeal pleomorphic rhabdomyosarcoma. ( 17481838 )
2007
44
Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice. ( 16785989 )
2006
45
Botryoid-type pleomorphic rhabdomyosarcoma of the renal pelvis in an adult. A rare case report and review of the literature. ( 16825824 )
2006
46
Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors. ( 16790082 )
2006
47
Pleomorphic rhabdomyosarcoma within a choledochal cyst; a rare cause of obstructive jaundice. ( 16967793 )
2006
48
Unusual manifestations of disseminated neoplasia at presentation: right-sided heart failure due to a massive cardiac metastasis and autoimmune thrombocytopenia in pleomorphic rhabdomyosarcoma of the adult. ( 16462513 )
2006
49
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal patient. ( 16799711 )
2006
50
Adult paravertebral pleomorphic rhabdomyosarcoma infiltrating diffusely the whole spinal axis. Case report. ( 15796361 )
2005

Variations for Pleomorphic Rhabdomyosarcoma

Expression for Pleomorphic Rhabdomyosarcoma

Search GEO for disease gene expression data for Pleomorphic Rhabdomyosarcoma.

Pathways for Pleomorphic Rhabdomyosarcoma

Pathways related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.27 PAX3 PAX7
2 10.91 DES MYOD1 PAX3 PAX7
3 10.9 MYOD1 PAX3
4 10.51 MYOD1 PAX7

GO Terms for Pleomorphic Rhabdomyosarcoma

Biological processes related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 skeletal muscle tissue development GO:0007519 8.96 MYOD1 PAX7
2 muscle organ development GO:0007517 8.8 MYOD1 PAX3 PAX7

Molecular functions related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 8.8 MYOD1 PAX3 PAX7

Sources for Pleomorphic Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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