MCID: PLM030
MIFTS: 49

Pleomorphic Rhabdomyosarcoma malady

Cancer diseases, Rare diseases categories
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Summaries for Pleomorphic Rhabdomyosarcoma

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MalaCards based summary: Pleomorphic Rhabdomyosarcoma, also known as anaplastic rhabdomyosarcoma, is related to rhabdomyosarcoma and liposarcoma. An important gene associated with Pleomorphic Rhabdomyosarcoma is MYH3 (myosin, heavy chain 3, skeletal muscle, embryonic), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Thyroid cancer. The compounds olomoucine and sodium nitroprusside have been mentioned in the context of this disorder. Affiliated tissues include uterus, heart and skeletal muscle, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Aliases & Classifications for Pleomorphic Rhabdomyosarcoma

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Sources:
8Disease Ontology, 48Orphanet, 62UMLS, 57SNOMED-CT, 39NCIt, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Pleomorphic Rhabdomyosarcoma, Aliases & Descriptions:

Name: Pleomorphic Rhabdomyosarcoma 8 48 62
Anaplastic Rhabdomyosarcoma 8 62
 
Pleomorphic Rhabdomyosarcoma, Adult Type 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 48 
Rare tumors


Characteristics (Orphanet epidemiological data):

48
pleomorphic rhabdomyosarcoma:
Prevalence: <1/1000000


External Ids:

Disease Ontology8 DOID:3250
NCIt39 C4258
SNOMED-CT57 77455004, 404054005
ICD10 via Orphanet26 C49.9
UMLS via Orphanet63 C0334480

Related Diseases for Pleomorphic Rhabdomyosarcoma

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Diseases in the Pleomorphic Rhabdomyosarcoma family:

Adult Pleomorphic Rhabdomyosarcoma

Diseases related to Pleomorphic Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma31.2DES, TP53, PAX7, MYOD1, MYOG, MB
2liposarcoma30.3MB, TP53, DES
3alveolar rhabdomyosarcoma30.1DES, PAX7, MYOD1, MYOG, MB
4colorectal cancer30.0TP53, EPHA3, MAPK3
5melanoma28.9DES, TP53, PAX7, EPHA3, MYOD1, MME
6malignant mesenchymoma10.4MYOD1, MYOG
7myoma10.4DES, MYOG
8pseudosarcomatous fibromatosis10.4MYOG, DES
9adult pleomorphic rhabdomyosarcoma10.4
10laryngitis10.4
11alveolar soft part sarcoma10.4MYOD1, MB
12myositis10.3MB, MYOD1
13rhabdoid tumor10.3MYOD1, DES
14myopathy congenital10.3MYOG, DES
15granular cell tumor10.3DES, MB
16childhood pleomorphic rhabdomyosarcoma10.3
17adenofibroma10.3MUC16
18endometrial stromal sarcoma10.3DES, MME
19embryonal cancer10.3MYOD1, MYOG, ALPPL2
20smooth muscle tumor10.2MME, DES
21malignant fibroxanthoma10.2TP53, MB
22neuropathy10.2MB, MYOG, MYOD1
23duchenne muscular dystrophy10.2MB, MYOD1, DES
24leiomyoma10.2DES, MYOG, MME
25neuromuscular disease10.2MB, DES
26endodermal sinus tumor10.1ALPPL2, MUC16
27uterine sarcoma10.1MB, MME, DES
28adenosarcoma10.1DES, MME, MB
29thrombocytopenia10.1
30choledochal cyst10.1
31obstructive jaundice10.1
32pleomorphic liposarcoma10.1
33fibrous histiocytoma10.1
34botryoid rhabdomyosarcoma10.1
35histiocytoma10.1
36mediastinitis10.1
37pulmonary embolism10.1
38cytomegalovirus infection10.1
39peripheral primitive neuroectodermal tumor10.1MYOG, MYOD1, PAX7, DES
40malignant mixed mullerian tumor10.1MB, TP53, DES
41fibroma10.1MUC16, DES
42myotonic dystrophy10.1MYOG, MYOD1
43cholangiocarcinoma10.1TP53, MME, ALPPL2
44wilms tumor10.1MME, MYOG, MYOD1, DES
45abrikosov's tumor10.1DES, MUC16
46uterine fibroid10.0DES, MYOG, MUC16
47medulloblastoma10.0DES, TP53, MAPK3
48factor vii deficiency10.0MB, MUC16
49lung benign neoplasm10.0MAPK3, MME, TP53
50b-cell lymphomas10.0MAPK3, MME, TP53

Graphical network of the top 20 diseases related to Pleomorphic Rhabdomyosarcoma:



Diseases related to pleomorphic rhabdomyosarcoma

Symptoms for Pleomorphic Rhabdomyosarcoma

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Drugs & Therapeutics for Pleomorphic Rhabdomyosarcoma

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Drug clinical trials:

Search ClinicalTrials for Pleomorphic Rhabdomyosarcoma

Search NIH Clinical Center for Pleomorphic Rhabdomyosarcoma

Genetic Tests for Pleomorphic Rhabdomyosarcoma

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Anatomical Context for Pleomorphic Rhabdomyosarcoma

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MalaCards organs/tissues related to Pleomorphic Rhabdomyosarcoma:

32
Uterus, Heart, Skeletal muscle, Kidney, Bone, Smooth muscle, Liver, Salivary gland, Adrenal gland

Animal Models for Pleomorphic Rhabdomyosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Rhabdomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7MAPK3, MYOD1, PAX7, TP53
2MP:00053857.9DES, TP53, EPHA3, MYOD1, MAPK3, MB
3MP:00053867.8DES, TP53, PAX7, EPHA3, MYOG, MAPK3
4MP:00053697.7DES, TP53, PAX7, MYOD1, MYOG, MAPK3
5MP:00053887.6MB, TP53, PAX7, EPHA3, MYOD1, MYOG
6MP:00053767.2DES, TP53, EPHA3, MYOD1, MYOG, MME
7MP:00107687.2DES, TP53, PAX7, EPHA3, MYOD1, MYOG

Publications for Pleomorphic Rhabdomyosarcoma

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Articles related to Pleomorphic Rhabdomyosarcoma:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
Pleomorphic rhabdomyosarcoma of the cerebellopontine angle in an adult: a review of literature. (24481021)
2014
2
Pleomorphic rhabdomyosarcoma in a patient with hereditary nonpolyposis colorectal cancer. (23319697)
2013
3
A pleomorphic rhabdomyosarcoma mimicking an inguinal hernia: a case report and review of the literature. (22611365)
2012
4
Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. (23002204)
2012
5
Pleomorphic rhabdomyosarcoma with pulmonary tumour embolism. (23203178)
2012
6
Multiple sites of highly amplified DNA sequences detected by molecular cytogenetic analysis in HS-RMS-2, a new pleomorphic rhabdomyosarcoma cell line. (22432055)
2012
7
Uterine pleomorphic rhabdomyosarcoma: a case report and review of literature. (21476391)
2011
8
Touch preparation of primary uterine pleomorphic rhabdomyosarcoma: report of a case with clinical cytopathologic features. (21053592)
2010
9
Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. (20173498)
2010
10
Pleomorphic rhabdomyosarcoma of the uterine corpus--a case report. (20825058)
2010
11
Electrochemotherapy treatment for bilateral pleomorphic rhabdomyosarcoma in a cat. (20492454)
2010
12
Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma. (19480930)
2009
13
Primary pleomorphic rhabdomyosarcoma of trunk in an adolescent. (19317765)
2009
14
A rare tumor of the diaphragm: pleomorphic rhabdomyosarcoma. (18442596)
2008
15
Primary pleomorphic rhabdomyosarcoma of the kidney in an adult. (18621001)
2008
16
A case of extremely chemoresistant pure pleomorphic rhabdomyosarcoma of the uterus associated with a high serum LDH level. (19051826)
2008
17
Primary mediastinal pleomorphic rhabdomyosarcoma: a case report. (18287801)
2008
18
Laryngeal pleomorphic rhabdomyosarcoma. (17481838)
2007
19
Palpebral pleomorphic rhabdomyosarcoma in a teenager. (16946759)
2007
20
Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. (17630111)
2007
21
Pleomorphic rhabdomyosarcoma within a choledochal cyst; a rare cause of obstructive jaundice. (16967793)
2006
22
Unusual manifestations of disseminated neoplasia at presentation: right-sided heart failure due to a massive cardiac metastasis and autoimmune thrombocytopenia in pleomorphic rhabdomyosarcoma of the adult. (16462513)
2006
23
Botryoid-type pleomorphic rhabdomyosarcoma of the renal pelvis in an adult. A rare case report and review of the literature. (16825824)
2006
24
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal patient. (16799711)
2006
25
Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors. (16790082)
2006
26
Pleomorphic rhabdomyosarcoma of the diaphragm. (15719879)
2005
27
Paratesticular pleomorphic rhabdomyosarcoma in an adult. (15787340)
2004
28
Pleomorphic rhabdomyosarcoma of the anterior abdominal wall following multimodality treatment for carcinoma of the rectum. (15173925)
2004
29
Pleomorphic rhabdomyosarcoma with pulmonary metastasis in a stranded Steller (northern) sea lion (Eumetopias jubatus). (15003477)
2004
30
Primary pleomorphic rhabdomyosarcoma of the kidney in adults: unusual tumor]. (14650305)
2003
31
Microsatellite instability in a pleomorphic rhabdomyosarcoma in a patient with hereditary non-polyposis colorectal cancer. (12940783)
2003
32
Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. (11406662)
2001
33
Pleomorphic rhabdomyosarcoma of the uterine corpus: a case report. (11446473)
2001
34
Pleomorphic rhabdomyosarcoma in children: four cases in the pediatric age group. (11510002)
2001
35
Unusual second malignancies following radiation therapy: subcutaneous pleomorphic rhabdomyosarcoma and cutaneous melanoma. Two case reports. (10955690)
2000
36
A new human pleomorphic rhabdomyosarcoma cell-line, HS-RMS-1, exhibiting MyoD1 and myogenin. (10853028)
2000
37
Uterine pleomorphic rhabdomyosarcoma in a patient receiving tamoxifen therapy. (10600318)
1999
38
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal woman with elevated serum CA125. (10479519)
1999
39
Laryngeal pleomorphic rhabdomyosarcoma. (9693927)
1998
40
A rare paratesticular pleomorphic rhabdomyosarcoma. (7656365)
1995
41
Pleomorphic rhabdomyosarcoma of the heart metastatic to bone. Report of a case with fine needle aspiration biopsy findings. (7762352)
1995
42
Identification of a spontaneous pleomorphic rhabdomyosarcoma in the thoracic and abdominal cavities of a female Wistar rat. (7725603)
1995
43
Pleomorphic rhabdomyosarcoma arising in association with the right pulmonary artery. (7979918)
1994
44
Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. (8333559)
1993
45
Pleomorphic rhabdomyosarcoma of the urinary bladder in association with recurrent urinary-tract infection. (2703059)
1989
46
Rapid remission of a large pleomorphic rhabdomyosarcoma with radiation and a novel schedule of simultaneous high-dose cisplatin. (2623385)
1989
47
Electron microscopic study of pleomorphic rhabdomyosarcoma of adult skeletal muscle. (6677005)
1983
48
Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. (223963)
1979
49
Pleomorphic rhabdomyosarcoma of the larynx. A case report and review of the literature. (956708)
1976
50
Pleomorphic rhabdomyosarcoma of the uvula--report of a case and review of the literature. (4773903)
1973

Variations for Pleomorphic Rhabdomyosarcoma

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Expression for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Expression patterns in normal tissues for genes affiliated with Pleomorphic Rhabdomyosarcoma

Search GEO for disease gene expression data for Pleomorphic Rhabdomyosarcoma.

Pathways for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Pathways related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8MAPK3, MME
29.6TP53, MAPK3
39.6MAPK3, TP53
49.6MYOD1, PAX7
59.4TP53, MYOD1
69.3MYOG, MYOD1
7
Show member pathways
9.3MYOG, MYOD1
8
Show member pathways
Alzheimers Disease37
9.3TP53, MME, MAPK3
9
Show member pathways
8.7MAPK3, MYH3, EPHA3, TP53, DES

Compounds for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Compounds related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1olomoucine44 1110.8MAPK3, TP53
2sodium nitroprusside449.8MB, MAPK3, MME
3phorbol 12,13-dibutyrate449.8MAPK3, EPHA3
4b 723449.7MUC16, DES
5hyaluronic acid44 2410.6MB, MUC16, DES
6sp 60012544 6110.6TP53, EPHA3, MAPK3
7resveratrol44 61 24 1112.6TP53, EPHA3, MAPK3
8c2ceramide449.5MAPK3, MYOG, TP53
9adriamycin449.5DES, TP53, MME, MB
10citrate449.5MYOD1, MME, MB
11amifostine44 1110.5ALPPL2, TP53
12geldanamycin44 50 61 1112.4MAPK3, MYOD1, TP53
13radicicol44 61 1111.3MAPK3, TP53
14lactate449.3MB, MME, MUC16, DES
15thymidine44 2410.3MAPK3, MME, TP53, DES
16n acetylcysteine449.3MB, MAPK3, TP53
17ascorbic acid44 2410.3MYOG, MME, MAPK3, MB
18estradiol44 24 1111.2DES, EPHA3, MUC16, MAPK3
19adenylate449.2DES, MYOG, MME, MB
20melphalan44 50 1111.2MB, MAPK3, MUC16, TP53
21actinomycin d449.1MME, MYOD1, TP53, DES
22cisplatin44 50 61 1112.1TP53, MUC16, MAPK3, MB
23progesterone44 28 61 24 1113.1DES, TP53, MUC16, MME
24fatty acid449.0DES, MYOD1, MYOG, MME
25doxorubicin44 50 1111.0DES, TP53, MUC16, MME, MB
26nitric oxide44 24 1110.9DES, EPHA3, MYOG, MME, MAPK3
27acetylcholine44 50 28 24 1112.8DES, MYOD1, MYOG, MME, MB
28bromodeoxyuridine448.8DES, MYOD1, MYOG, MME, MAPK3
2912-o-tetradecanoylphorbol 13-acetate448.8DES, MYOD1, MYOG, MME, MAPK3
30oligonucleotide448.7TP53, PAX7, MYOD1, MYOG
31threonine448.6DES, EPHA3, MYOD1, MUC16, MAPK3
32phosphatidylinositol448.6EPHA3, MYOD1, MME, MAPK3
33cyclic amp44 249.6ALPPL2, MAPK3, MYOD1, DES
34steroid448.6DES, MYOD1, MYOG, MUC16, MME
35leucine448.6ALPPL2, MME, MYOD1, EPHA3
36arginine448.5DES, TP53, MYOD1, MME, MAPK3, MB
37oxygen44 249.4DES, EPHA3, MYOD1, MYOG, MME, MB
38creatinine448.3DES, MYOD1, MYOG, MUC16, MME, MB
39retinoic acid44 249.3DES, TP53, MYOD1, MYOG, MME, MAPK3
40h2o2448.2DES, TP53, EPHA3, MUC16, MME, MAPK3
41glucose448.2DES, EPHA3, MYOD1, MYOG, MUC16, MME
42butyrate448.1ALPPL2, MAPK3, MYOG, MYOD1, TP53
43calcium44 50 24 1111.1DES, EPHA3, MYOD1, MYOG, MME, MAPK3
44cysteine448.0DES, EPHA3, MYOD1, MYOG, MME, MAPK3
45tyrosine447.8DES, EPHA3, MYOD1, MYOG, MUC16, MME
46testosterone44 61 24 1110.5DES, EPHA3, MYOD1, MYOG, MUC16, MME
47estrogen447.4DES, TP53, EPHA3, MYOD1, MYOG, MUC16
48vegf447.1DES, TP53, EPHA3, MYOD1, MYOG, MUC16
49serine447.1DES, TP53, EPHA3, MYOD1, MYOG, MUC16
50paraffin447.0MB, DES, TP53, MYOD1, MYOG, MUC16

GO Terms for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Biological processes related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.9MME, TP53
2muscle filament slidingGO:0300499.8MYH3, DES
3sensory perception of painGO:0192339.8MAPK3, MME
4positive regulation of cell cycle arrestGO:0711589.6MYOG, TP53
5muscle cell fate commitmentGO:0426939.6MYOD1, MYOG
6skeletal muscle fiber developmentGO:0487419.5MYOG, MYOD1
7cellular response to estradiol stimulusGO:0713929.5MYOD1, MYOG
8positive regulation of muscle cell differentiationGO:0511499.4MYOG, MYOD1
9muscle cell differentiationGO:0426929.3MYOD1, MYOG
10skeletal muscle tissue developmentGO:0075199.0MYOG, MYOD1
11positive regulation of transcription from RNA polymerase II promoterGO:0459448.4MAPK3, MYOG, MYOD1, PAX7, TP53

Molecular functions related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0012289.5MYOG, TP53
2core promoter bindingGO:0010479.3MYOG, MYOD1
3chromatin DNA bindingGO:0314909.2MYOG, MYOD1
4E-box bindingGO:0708889.0MYOG, MYOD1

Products for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Sources for Pleomorphic Rhabdomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet