MCID: PLM030
MIFTS: 42

Pleomorphic Rhabdomyosarcoma malady

Cancer diseases, Rare diseases categories

Aliases & Classifications for Pleomorphic Rhabdomyosarcoma

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Sources:
9Disease Ontology, 47Orphanet, 60UMLS, 55SNOMED-CT, 38NCIt, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Pleomorphic Rhabdomyosarcoma, Aliases & Descriptions:

Name: Pleomorphic Rhabdomyosarcoma 9 47 60
Anaplastic Rhabdomyosarcoma 9 60
 
Pleomorphic Rhabdomyosarcoma, Adult Type 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 47 
Rare tumors


Characteristics (Orphanet epidemiological data):

47
pleomorphic rhabdomyosarcoma:
Prevalence: <1/1000000 (Europe)


External Ids:

Disease Ontology9 DOID:3250
NCIt38 C4258
Orphanet47 293199
SNOMED-CT55 77455004, 404054005
ICD10 via Orphanet26 C49.9
UMLS via Orphanet61 C0334480

Summaries for Pleomorphic Rhabdomyosarcoma

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MalaCards based summary: Pleomorphic Rhabdomyosarcoma, also known as anaplastic rhabdomyosarcoma, is related to rhabdomyosarcoma and liposarcoma. An important gene associated with Pleomorphic Rhabdomyosarcoma is MYH3 (myosin, heavy chain 3, skeletal muscle, embryonic), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Thyroid cancer. The compounds olomoucine and sodium nitroprusside have been mentioned in the context of this disorder. Affiliated tissues include uterus, heart and skeletal muscle, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Related Diseases for Pleomorphic Rhabdomyosarcoma

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Diseases in the Pleomorphic Rhabdomyosarcoma family:

Adult Pleomorphic Rhabdomyosarcoma

Diseases related to Pleomorphic Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma31.2DES, TP53, PAX7, MYOD1, MYOG, MB
2liposarcoma30.3MB, TP53, DES
3colorectal cancer30.0TP53, EPHA3, MAPK3
4melanoma28.9DES, TP53, PAX7, EPHA3, MYOD1, MME
5malignant mesenchymoma10.4MYOD1, MYOG
6myoma10.4DES, MYOG
7adult pleomorphic rhabdomyosarcoma10.4
8childhood pleomorphic rhabdomyosarcoma10.4
9laryngitis10.4
10pseudosarcomatous fibromatosis10.4MYOG, DES
11alveolar soft-part sarcoma10.4MYOD1, MB
12myositis10.3MB, MYOD1
13rhabdoid tumor10.3MYOD1, DES
14myopathy congenital10.3MYOG, DES
15granular cell tumor10.3DES, MB
16adenofibroma10.3MUC16
17endometrial stromal sarcoma10.3DES, MME
18embryonal cancer10.3MYOD1, MYOG, ALPPL2
19smooth muscle tumor10.2MME, DES
20malignant fibroxanthoma10.2TP53, MB
21neuropathy10.2MB, MYOG, MYOD1
22duchenne muscular dystrophy10.2MB, MYOD1, DES
23leiomyoma10.2DES, MYOG, MME
24neuromuscular disease10.2MB, DES
25thrombocytopenia10.1
26choledochal cyst10.1
27obstructive jaundice10.1
28fibrous histiocytoma10.1
29pleomorphic liposarcoma10.1
30botryoid rhabdomyosarcoma10.1
31histiocytoma10.1
32mediastinitis10.1
33pulmonary embolism10.1
34cytomegalovirus infection10.1
35endodermal sinus tumor10.1ALPPL2, MUC16
36uterine sarcoma10.1MB, MME, DES
37adenosarcoma10.1DES, MME, MB
38ewing sarcoma10.1MYOG, MYOD1, PAX7, DES
39malignant mixed mullerian tumor10.1MB, TP53, DES
40fibroma10.1MUC16, DES
41myotonic dystrophy10.1MYOG, MYOD1
42cholangiocarcinoma10.1TP53, MME, ALPPL2
43wilms tumor10.1MME, MYOG, MYOD1, DES
44abrikosov's tumor10.1DES, MUC16
45uterine fibroid10.0DES, MYOG, MUC16
46medulloblastoma10.0DES, TP53, MAPK3
47factor vii deficiency10.0MB, MUC16
48lung benign neoplasm10.0MAPK3, MME, TP53
49b-cell lymphomas10.0MAPK3, MME, TP53
50rhabdomyosarcoma 2, alveolar9.9DES, PAX7, MYOD1, MYOG, MB

Graphical network of the top 20 diseases related to Pleomorphic Rhabdomyosarcoma:



Diseases related to pleomorphic rhabdomyosarcoma

Symptoms for Pleomorphic Rhabdomyosarcoma

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Drugs & Therapeutics for Pleomorphic Rhabdomyosarcoma

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Drug clinical trials:

Search ClinicalTrials for Pleomorphic Rhabdomyosarcoma

Search NIH Clinical Center for Pleomorphic Rhabdomyosarcoma

Genetic Tests for Pleomorphic Rhabdomyosarcoma

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Anatomical Context for Pleomorphic Rhabdomyosarcoma

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MalaCards organs/tissues related to Pleomorphic Rhabdomyosarcoma:

31
Uterus, Heart, Skeletal muscle, Kidney, Bone, Smooth muscle, Liver, Salivary gland, Adrenal gland, Breast, Skin

Animal Models for Pleomorphic Rhabdomyosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Rhabdomyosarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7MAPK3, MYOD1, PAX7, TP53
2MP:00053857.9DES, TP53, EPHA3, MYOD1, MAPK3, MB
3MP:00053867.8DES, TP53, PAX7, EPHA3, MYOG, MAPK3
4MP:00053697.7DES, TP53, PAX7, MYOD1, MYOG, MAPK3
5MP:00053887.6MB, TP53, PAX7, EPHA3, MYOD1, MYOG
6MP:00053767.2DES, TP53, EPHA3, MYOD1, MYOG, MME
7MP:00107687.2DES, TP53, PAX7, EPHA3, MYOD1, MYOG

Publications for Pleomorphic Rhabdomyosarcoma

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Articles related to Pleomorphic Rhabdomyosarcoma:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Pelvic pleomorphic rhabdomyosarcoma presenting as oliguria in a 61-year-old woman. (25880675)
2015
2
Cutaneous Pleomorphic Rhabdomyosarcoma Occurring on Sun Damaged Skin: A Case Report. (25140666)
2014
3
Pleomorphic rhabdomyosarcoma of the cerebellopontine angle in an adult: a review of literature. (24481021)
2014
4
Pleomorphic rhabdomyosarcoma in a patient with hereditary nonpolyposis colorectal cancer. (23319697)
2013
5
A pleomorphic rhabdomyosarcoma mimicking an inguinal hernia: a case report and review of the literature. (22611365)
2012
6
Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. (23002204)
2012
7
Pleomorphic rhabdomyosarcoma with pulmonary tumour embolism. (23203178)
2012
8
Multiple sites of highly amplified DNA sequences detected by molecular cytogenetic analysis in HS-RMS-2, a new pleomorphic rhabdomyosarcoma cell line. (22432055)
2012
9
Uterine pleomorphic rhabdomyosarcoma: a case report and review of literature. (21476391)
2011
10
Touch preparation of primary uterine pleomorphic rhabdomyosarcoma: report of a case with clinical cytopathologic features. (21053592)
2010
11
A rare case of paratesticular pleomorphic rhabdomyosarcoma diagnosed by fine needle aspiration: a case report. (19790247)
2010
12
Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. (20173498)
2010
13
Pleomorphic rhabdomyosarcoma of the uterine corpus--a case report. (20825058)
2010
14
Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma. (19480930)
2009
15
Primary pleomorphic rhabdomyosarcoma of trunk in an adolescent. (19317765)
2009
16
A rare tumor of the diaphragm: pleomorphic rhabdomyosarcoma. (18442596)
2008
17
Primary pleomorphic rhabdomyosarcoma of the kidney in an adult. (18621001)
2008
18
A case of extremely chemoresistant pure pleomorphic rhabdomyosarcoma of the uterus associated with a high serum LDH level. (19051826)
2008
19
Primary mediastinal pleomorphic rhabdomyosarcoma: a case report. (18287801)
2008
20
Laryngeal pleomorphic rhabdomyosarcoma. (17481838)
2007
21
Palpebral pleomorphic rhabdomyosarcoma in a teenager. (16946759)
2007
22
Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. (17630111)
2007
23
Pleomorphic rhabdomyosarcoma within a choledochal cyst; a rare cause of obstructive jaundice. (16967793)
2006
24
Unusual manifestations of disseminated neoplasia at presentation: right-sided heart failure due to a massive cardiac metastasis and autoimmune thrombocytopenia in pleomorphic rhabdomyosarcoma of the adult. (16462513)
2006
25
Botryoid-type pleomorphic rhabdomyosarcoma of the renal pelvis in an adult. A rare case report and review of the literature. (16825824)
2006
26
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal patient. (16799711)
2006
27
Pleomorphic rhabdomyosarcoma of the diaphragm. (15719879)
2005
28
Paratesticular pleomorphic rhabdomyosarcoma in an adult. (15787340)
2004
29
Pleomorphic rhabdomyosarcoma of the anterior abdominal wall following multimodality treatment for carcinoma of the rectum. (15173925)
2004
30
Pleomorphic rhabdomyosarcoma with pulmonary metastasis in a stranded Steller (northern) sea lion (Eumetopias jubatus). (15003477)
2004
31
Primary pleomorphic rhabdomyosarcoma of the kidney in adults: unusual tumor]. (14650305)
2003
32
Microsatellite instability in a pleomorphic rhabdomyosarcoma in a patient with hereditary non-polyposis colorectal cancer. (12940783)
2003
33
Pleomorphic rhabdomyosarcoma in an adult forearm: a case report. (11810631)
2002
34
Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. (11406662)
2001
35
Pleomorphic rhabdomyosarcoma of the uterine corpus: a case report. (11446473)
2001
36
Unusual second malignancies following radiation therapy: subcutaneous pleomorphic rhabdomyosarcoma and cutaneous melanoma. Two case reports. (10955690)
2000
37
A new human pleomorphic rhabdomyosarcoma cell-line, HS-RMS-1, exhibiting MyoD1 and myogenin. (10853028)
2000
38
Uterine pleomorphic rhabdomyosarcoma in a patient receiving tamoxifen therapy. (10600318)
1999
39
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal woman with elevated serum CA125. (10479519)
1999
40
Laryngeal pleomorphic rhabdomyosarcoma. (9693927)
1998
41
A rare paratesticular pleomorphic rhabdomyosarcoma. (7656365)
1995
42
Pleomorphic rhabdomyosarcoma of the heart metastatic to bone. Report of a case with fine needle aspiration biopsy findings. (7762352)
1995
43
Identification of a spontaneous pleomorphic rhabdomyosarcoma in the thoracic and abdominal cavities of a female Wistar rat. (7725603)
1995
44
Pleomorphic rhabdomyosarcoma arising in association with the right pulmonary artery. (7979918)
1994
45
Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. (8333559)
1993
46
Pleomorphic rhabdomyosarcoma of the urinary bladder in association with recurrent urinary-tract infection. (2703059)
1989
47
Rapid remission of a large pleomorphic rhabdomyosarcoma with radiation and a novel schedule of simultaneous high-dose cisplatin. (2623385)
1989
48
Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. (223963)
1979
49
Pleomorphic rhabdomyosarcoma of the larynx. A case report and review of the literature. (956708)
1976
50
Pleomorphic rhabdomyosarcoma of the uvula--report of a case and review of the literature. (4773903)
1973

Variations for Pleomorphic Rhabdomyosarcoma

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Expression for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Search GEO for disease gene expression data for Pleomorphic Rhabdomyosarcoma.

Pathways for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Pathways related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8MAPK3, MME
29.6TP53, MAPK3
39.6MAPK3, TP53
49.6MYOD1, PAX7
59.4TP53, MYOD1
69.3MYOG, MYOD1
7
Show member pathways
9.3MYOG, MYOD1
8
Show member pathways
Alzheimers Disease36
9.3TP53, MME, MAPK3
9
Show member pathways
8.7MAPK3, MYH3, EPHA3, TP53, DES

Compounds for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Compounds related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1olomoucine43 1210.8MAPK3, TP53
2sodium nitroprusside439.8MB, MAPK3, MME
3phorbol 12,13-dibutyrate439.8MAPK3, EPHA3
4b 723439.7MUC16, DES
5hyaluronic acid43 2410.6MB, MUC16, DES
6sp 60012543 5910.6TP53, EPHA3, MAPK3
7resveratrol43 59 24 1212.6TP53, EPHA3, MAPK3
8c2ceramide439.5MAPK3, MYOG, TP53
9adriamycin439.5DES, TP53, MME, MB
10citrate439.5MYOD1, MME, MB
11amifostine43 1210.5ALPPL2, TP53
12geldanamycin43 49 59 1212.4MAPK3, MYOD1, TP53
13radicicol43 59 1211.3MAPK3, TP53
14lactate439.3MB, MME, MUC16, DES
15thymidine43 2410.3MAPK3, MME, TP53, DES
16n acetylcysteine439.3MB, MAPK3, TP53
17ascorbic acid43 2410.3MYOG, MME, MAPK3, MB
18estradiol43 24 1211.2DES, EPHA3, MUC16, MAPK3
19adenylate439.2DES, MYOG, MME, MB
20melphalan43 49 1211.2MB, MAPK3, MUC16, TP53
21actinomycin d439.1MME, MYOD1, TP53, DES
22cisplatin43 49 59 1212.1TP53, MUC16, MAPK3, MB
23progesterone43 28 59 24 1213.1DES, TP53, MUC16, MME
24fatty acid439.0DES, MYOD1, MYOG, MME
25doxorubicin43 49 1211.0DES, TP53, MUC16, MME, MB
26nitric oxide43 24 1210.9DES, EPHA3, MYOG, MME, MAPK3
27acetylcholine43 49 28 24 1212.8DES, MYOD1, MYOG, MME, MB
28bromodeoxyuridine438.8DES, MYOD1, MYOG, MME, MAPK3
2912-o-tetradecanoylphorbol 13-acetate438.8DES, MYOD1, MYOG, MME, MAPK3
30oligonucleotide438.7TP53, PAX7, MYOD1, MYOG
31threonine438.6DES, EPHA3, MYOD1, MUC16, MAPK3
32phosphatidylinositol438.6EPHA3, MYOD1, MME, MAPK3
33cyclic amp43 249.6ALPPL2, MAPK3, MYOD1, DES
34steroid438.6DES, MYOD1, MYOG, MUC16, MME
35leucine438.6ALPPL2, MME, MYOD1, EPHA3
36arginine438.5DES, TP53, MYOD1, MME, MAPK3, MB
37oxygen43 249.4DES, EPHA3, MYOD1, MYOG, MME, MB
38creatinine438.3DES, MYOD1, MYOG, MUC16, MME, MB
39retinoic acid43 249.3DES, TP53, MYOD1, MYOG, MME, MAPK3
40h2o2438.2DES, TP53, EPHA3, MUC16, MME, MAPK3
41glucose438.2DES, EPHA3, MYOD1, MYOG, MUC16, MME
42butyrate438.1ALPPL2, MAPK3, MYOG, MYOD1, TP53
43calcium43 49 24 1211.1DES, EPHA3, MYOD1, MYOG, MME, MAPK3
44cysteine438.0DES, EPHA3, MYOD1, MYOG, MME, MAPK3
45tyrosine437.8DES, EPHA3, MYOD1, MYOG, MUC16, MME
46testosterone43 59 24 1210.5DES, EPHA3, MYOD1, MYOG, MUC16, MME
47estrogen437.4DES, TP53, EPHA3, MYOD1, MYOG, MUC16
48vegf437.1DES, TP53, EPHA3, MYOD1, MYOG, MUC16
49serine437.1DES, TP53, EPHA3, MYOD1, MYOG, MUC16
50paraffin437.0MB, DES, TP53, MYOD1, MYOG, MUC16

GO Terms for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Biological processes related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:00903999.9MME, TP53
2muscle filament slidingGO:00300499.8MYH3, DES
3sensory perception of painGO:00192339.8MAPK3, MME
4positive regulation of cell cycle arrestGO:00711589.6MYOG, TP53
5muscle cell fate commitmentGO:00426939.6MYOD1, MYOG
6skeletal muscle fiber developmentGO:00487419.5MYOG, MYOD1
7cellular response to estradiol stimulusGO:00713929.5MYOD1, MYOG
8positive regulation of muscle cell differentiationGO:00511499.4MYOG, MYOD1
9muscle cell differentiationGO:00426929.3MYOD1, MYOG
10skeletal muscle tissue developmentGO:00075199.0MYOG, MYOD1
11positive regulation of transcription from RNA polymerase II promoterGO:00459448.4MAPK3, MYOG, MYOD1, PAX7, TP53

Molecular functions related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:00012289.5MYOG, TP53
2core promoter bindingGO:00010479.3MYOG, MYOD1
3chromatin DNA bindingGO:00314909.2MYOG, MYOD1
4E-box bindingGO:00708889.0MYOG, MYOD1

Products for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Sources for Pleomorphic Rhabdomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet