MCID: PLM030
MIFTS: 38

Pleomorphic Rhabdomyosarcoma malady

Cancer category

Summaries for Pleomorphic Rhabdomyosarcoma

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33MalaCards
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MalaCards: Pleomorphic Rhabdomyosarcoma, also known as anaplastic rhabdomyosarcoma, is related to colorectal cancer and alveolar rhabdomyosarcoma. An important gene associated with Pleomorphic Rhabdomyosarcoma is MYH3 (myosin, heavy chain 3, skeletal muscle, embryonic), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Thyroid cancer. The compounds glucose and sodium nitroprusside have been mentioned in the context of this disorder. Related mouse phenotypes are muscle and cardiovascular system.

Aliases & Classifications for Pleomorphic Rhabdomyosarcoma

Sources:
8Disease Ontology, 49Orphanet, 61UMLS, 57SNOMED-CT, 40NCIt, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Characteristics (Orphanet epidemiological data):

49
pleomorphic rhabdomyosarcoma:
Prevalence: <1/1000000


Aliases & Descriptions:

pleomorphic rhabdomyosarcoma 8 49 61
anaplastic rhabdomyosarcoma 8 61
pleomorphic rhabdomyosarcoma, adult type 8


External Ids:

Disease Ontology8 DOID:3250
NCIt40 C4258
SNOMED-CT57 404054005, 77455004
ICD10 via Orphanet26 C49.9

Related Diseases for Pleomorphic Rhabdomyosarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pleomorphic Rhabdomyosarcoma family:

adult pleomorphic rhabdomyosarcoma

Diseases related to Pleomorphic Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer30.3TP53, ALPPL2, MUC16
2alveolar rhabdomyosarcoma30.3MB, DES, MYOD1, MYOG, PAX7
3adult pleomorphic rhabdomyosarcoma10.7
4adult botryoid rhabdomyosarcoma10.3
5childhood pleomorphic rhabdomyosarcoma10.3
6botryoid rhabdomyosarcoma10.3
7obstructive jaundice10.1
8fibrous histiocytoma10.1
9pleomorphic carcinoma10.1
10pleomorphic liposarcoma10.1
11rectum rhabdomyosarcoma10.1
12liver rhabdomyosarcoma10.1
13choledochal cyst10.1
14thrombocytopenia10.1
15pleomorphic malignant fibrous histiocytoma10.1
16cytomegalovirus infection10.1
17teratoma10.0ALPPL2
18angiomyolipoma10.0DES
19chondrosarcoma10.0DES
20pancreatitis10.0ALPPL2
21fibrosarcoma10.0DES
22chordoma10.0DES
23cystadenoma10.0MME
24glomerulonephritis10.0MME
25myeloma10.0ALPPL2
26malignant mesenchymoma10.0MYOG, MYOD1
27kidney cancer10.0TP53
28seminoma10.0ALPPL2
29bladder carcinoma10.0TP53
30nephroblastoma10.0TP53
31rhabdoid tumor10.0DES, MYOD1
32adrenocortical carcinoma10.0TP53
33pseudosarcomatous fibromatosis10.0MYOG, DES
34ductal carcinoma in situ10.0TP53
35alveolar soft part sarcoma10.0MYOD1, MB
36gastrointestinal stromal tumor10.0DES
37smooth muscle tumor10.0DES, MME
38myositis10.0MYOD1, MB
39endometriosis10.0MUC16
40myopathy congenital10.0DES, MYOG
41congestive heart failure10.0MME
42endometrial stromal sarcoma10.0DES, MME
43cervical adenocarcinoma10.0MUC16
44malignant fibroxanthoma10.0MYOG, MYOD1, DES
45meigs syndrome10.0MUC16
46adenofibroma10.0MUC16
47leiomyoma10.0MME, MYOG, DES
48embryonal cancer10.0ALPPL2, MYOG, MYOD1
49dementia10.0MAPK3
50neuropathy10.0MYOG, MYOD1, MB

Graphical network of the top 20 diseases related to Pleomorphic Rhabdomyosarcoma:



Diseases related to pleomorphic rhabdomyosarcoma

Clinical Features for Pleomorphic Rhabdomyosarcoma

Drugs & Therapeutics for Pleomorphic Rhabdomyosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pleomorphic Rhabdomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Rhabdomyosarcoma

Search NIH Clinical Center for Pleomorphic Rhabdomyosarcoma

Search CenterWatch for Pleomorphic Rhabdomyosarcoma

Genetic Tests for Pleomorphic Rhabdomyosarcoma

Anatomical Context for Pleomorphic Rhabdomyosarcoma

Animal Models for Pleomorphic Rhabdomyosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pleomorphic Rhabdomyosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4MB, MAPK3, MYOD1, PAX7, TP53
2MP:00053858.0DES, MAPK3, MYOD1, EPHA3, TP53, MB
3MP:00053887.5TP53, PAX7, EPHA3, MYOG, MYOD1, MAPK3
4MP:00053767.1MB, DES, MAPK3, MYOD1, MYOG, EPHA3
5MP:00107686.8MB, DES, MAPK3, MYOD1, MYOG, EPHA3

Publications for Pleomorphic Rhabdomyosarcoma

Sources:
51PubMed
See all sources

Articles related to Pleomorphic Rhabdomyosarcoma:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Primary pleomorphic rhabdomyosarcoma of the adrenal gland in an adult: A case report. (24348835)
2014
2
Pleomorphic rhabdomyosarcoma in a patient with hereditary nonpolyposis colorectal cancer. (23319697)
2013
3
Postradiation cutaneous pleomorphic rhabdomyosarcoma with extracellular collagen deposits reminiscent of so-called amianthoid fibers. (24341853)
2013
4
Paratesticular pleomorphic rhabdomyosarcoma: a report of two cases. (23476881)
2013
5
A pleomorphic rhabdomyosarcoma mimicking an inguinal hernia: a case report and review of the literature. (22611365)
2012
6
Pleomorphic rhabdomyosarcoma with pulmonary tumour embolism. (23203178)
2012
7
Glypican-3 is expressed in rhabdomyosarcomas but not adult spindle cell and pleomorphic sarcomas. (21493758)
2011
8
Touch preparation of primary uterine pleomorphic rhabdomyosarcoma: report of a case with clinical cytopathologic features. (21053592)
2010
9
A rare case of paratesticular pleomorphic rhabdomyosarcoma diagnosed by fine needle aspiration: a case report. (19790247)
2010
10
Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. (20173498)
2010
11
p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma. (20662002)
2010
12
Pleomorphic rhabdomyosarcoma pulmonary embolism. (19713348)
2009
13
Surgical management of an inoperable giant pleomorphic rhabdomyosarcoma of the chest wall. (19704344)
2009
14
A rare tumor of the diaphragm: pleomorphic rhabdomyosarcoma. (18442596)
2008
15
Primary pleomorphic rhabdomyosarcoma of the kidney in an adult. (18621001)
2008
16
A case of extremely chemoresistant pure pleomorphic rhabdomyosarcoma of the uterus associated with a high serum LDH level. (19051826)
2008
17
Primary mediastinal pleomorphic rhabdomyosarcoma: a case report. (18287801)
2008
18
Laryngeal pleomorphic rhabdomyosarcoma. (17481838)
2007
19
Palpebral pleomorphic rhabdomyosarcoma in a teenager. (16946759)
2007
20
Unusual manifestations of disseminated neoplasia at presentation: right-sided heart failure due to a massive cardiac metastasis and autoimmune thrombocytopenia in pleomorphic rhabdomyosarcoma of the adult. (16462513)
2006
21
Botryoid-type pleomorphic rhabdomyosarcoma of the renal pelvis in an adult. A rare case report and review of the literature. (16825824)
2006
22
Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors. (16790082)
2006
23
Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice. (16785989)
2006
24
Adult paravertebral pleomorphic rhabdomyosarcoma infiltrating diffusely the whole spinal axis. Case report. (15796361)
2005
25
A retroperitoneal mass in an elderly woman. Pleomorphic rhabdomyosarcoma, classic variant, with reactive osteoclast-like giant cells. (15859650)
2005
26
Paratesticular pleomorphic rhabdomyosarcoma in an adult. (15787340)
2004
27
Pleomorphic rhabdomyosarcoma of the anterior abdominal wall following multimodality treatment for carcinoma of the rectum. (15173925)
2004
28
Anaplastic (pleomorphic) subtype embryonal rhabdomyosarcoma of the cervix. (12942264)
2004
29
Primary pleomorphic rhabdomyosarcoma of the kidney in adults: unusual tumor]. (14650305)
2003
30
Primary pleomorphic rhabdomyosarcoma of the liver: a case report. (12629994)
2003
31
Chromosomal imbalances in pleomorphic rhabdomyosarcomas and identification of the alveolar rhabdomyosarcoma-associated PAX3-FOXO1A fusion gene in one case. (12550764)
2003
32
Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. (11406662)
2001
33
Pleomorphic rhabdomyosarcoma of the uterine corpus: a case report. (11446473)
2001
34
Unusual second malignancies following radiation therapy: subcutaneous pleomorphic rhabdomyosarcoma and cutaneous melanoma. Two case reports. (10955690)
2000
35
A new human pleomorphic rhabdomyosarcoma cell-line, HS-RMS-1, exhibiting MyoD1 and myogenin. (10853028)
2000
36
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal woman with elevated serum CA125. (10479519)
1999
37
Laryngeal pleomorphic rhabdomyosarcoma. (9693927)
1998
38
Pleomorphic rhabdomyosarcoma of the submandibular salivary gland. (9141408)
1997
39
Laryngeal pleomorphic rhabdomyosarcoma. A critical review of the literature. (8604891)
1996
40
A rare paratesticular pleomorphic rhabdomyosarcoma. (7656365)
1995
41
Pleomorphic rhabdomyosarcoma of the heart metastatic to bone. Report of a case with fine needle aspiration biopsy findings. (7762352)
1995
42
Pleomorphic rhabdomyosarcoma arising in association with the right pulmonary artery. (7979918)
1994
43
Pleomorphic rhabdomyosarcoma of the urinary bladder in association with recurrent urinary-tract infection. (2703059)
1989
44
Rapid remission of a large pleomorphic rhabdomyosarcoma with radiation and a novel schedule of simultaneous high-dose cisplatin. (2623385)
1989
45
Pleomorphic rhabdomyosarcoma of the uterus. Case report with a review of the literature. (6518159)
1984
46
Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. (223963)
1979
47
Pleomorphic rhabdomyosarcoma of the larynx. A case report and review of the literature. (956708)
1976
48
Pleomorphic Rhabdomyosarcoma: response to irradiation. (1135403)
1975
49
Pleomorphic rhabdomyosarcoma of the uvula--report of a case and review of the literature. (4773903)
1973
50
Pleomorphic rhabdomyosarcoma of the gingiva. Report of a case. (5249509)
1969

Genetic Variations for Pleomorphic Rhabdomyosarcoma

Expression for genes affiliated with Pleomorphic Rhabdomyosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pleomorphic Rhabdomyosarcoma

Search GEO for disease gene expression data for Pleomorphic Rhabdomyosarcoma.

Pathways for genes affiliated with Pleomorphic Rhabdomyosarcoma

Sources:
50PharmGKB, 30KEGG, 52QIAGEN
See all sources

Pathways related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8MME, MAPK3
29.6TP53, MAPK3
3
Hide members
8.7TP53, EPHA3, MYH3, MAPK3, DES

Compounds for genes affiliated with Pleomorphic Rhabdomyosarcoma

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 24HMDB, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1glucose459.8MUC16, MYOG
2sodium nitroprusside459.7MME, MAPK3, MB
3fatty acid459.6MYOG, MYOD1
4olomoucine45 1110.5TP53, MAPK3
5sp 60012545 6010.5TP53, EPHA3, MAPK3
6resveratrol45 60 11 2412.5MAPK3, EPHA3, TP53
7adriamycin459.5MB, DES, MME, TP53
8c2ceramide459.5TP53, MYOG, MAPK3
9amifostine45 1110.5TP53, ALPPL2
10hyaluronic acid45 2410.4MUC16, DES, MB
11citrate459.4MME, MYOD1, MB
12geldanamycin45 50 60 1112.4TP53, MYOD1, MAPK3
13ascorbic acid45 2410.3MB, MAPK3, MYOG, MME
14lactate459.2MB, DES, MUC16, MME
15thymidine45 2410.2DES, MAPK3, MME, TP53
16melphalan45 1110.2TP53, MUC16, MAPK3, MB
17estradiol45 11 2411.2DES, MAPK3, MUC16, EPHA3
18actinomycin d459.1DES, MYOD1, MME, TP53
19creatinine459.1MB, MYOD1, MUC16, MME
20adenylate459.0MB, DES, MYOG, MME
21doxorubicin45 50 1111.0MB, DES, MUC16, MME, TP53
22cisplatin45 50 60 1112.0MB, MAPK3, MUC16, TP53
23progesterone45 60 29 11 2412.9TP53, MME, MUC16, DES
24nitric oxide45 11 2410.9DES, MAPK3, MYOG, EPHA3, MME
25acetylcholine45 50 29 11 2412.8MME, MYOG, MYOD1, DES, MB
26bromodeoxyuridine458.8DES, MAPK3, MYOD1, MYOG, MME
2712-o-tetradecanoylphorbol 13-acetate458.8DES, MAPK3, MYOD1, MYOG, MME
28threonine458.6DES, MAPK3, MYOD1, MUC16, EPHA3
29steroid458.6DES, MYOD1, MYOG, MUC16, MME
30arginine458.5MB, DES, MAPK3, MYOD1, MME, TP53
31leucine458.4MYOD1, EPHA3, MME, ALPPL2
32oxygen45 249.4MB, DES, MYOD1, MYOG, EPHA3, MME
33retinoic acid45 249.3DES, MAPK3, MYOD1, MYOG, MME, TP53
34h2o2458.2MB, DES, MAPK3, MUC16, EPHA3, MME
35butyrate458.1MAPK3, MYOD1, MYOG, ALPPL2, TP53
36cyclic amp45 249.1DES, MAPK3, MYOD1, ALPPL2
37cysteine458.0MB, DES, MAPK3, MYOD1, MYOG, EPHA3
38tyrosine457.8DES, MAPK3, MYOD1, MYOG, MUC16, EPHA3
39testosterone45 60 11 2410.5MB, DES, MAPK3, MYOD1, MYOG, MUC16
40estrogen457.4DES, MAPK3, MYOD1, MYOG, MUC16, EPHA3
41vegf457.1MB, DES, MAPK3, MYOD1, MYOG, MUC16
42serine457.1MB, DES, MAPK3, MYOD1, MYOG, MUC16
43paraffin457.0TP53, MB, DES, MYOD1, MYOG, MUC16

GO Terms for genes affiliated with Pleomorphic Rhabdomyosarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myofibrilGO:0300169.6MYOD1, MYH3

Biological processes related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.8TP53, MME
2muscle cell fate commitmentGO:0426939.5MYOG, MYOD1
3positive regulation of cell cycle arrestGO:0711589.4TP53, MYOG
4skeletal muscle fiber developmentGO:0487419.4MYOD1, MYOG
5cellular response to estradiol stimulusGO:0713929.3MYOG, MYOD1
6phosphorylationGO:0163109.3ALPPL2, MAPK3
7positive regulation of muscle cell differentiationGO:0511499.0MYOG, MYOD1
8positive regulation of transcription from RNA polymerase II promoterGO:0459448.3MAPK3, MYOD1, MYOG, PAX7, TP53

Molecular functions related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positiGO:0012289.5TP53, MYOG
2E-box bindingGO:0708889.3MYOG, MYOD1
3chromatin DNA bindingGO:0314909.2MYOG, MYOD1
4core promoter bindingGO:0010479.0MYOG, MYOD1

Products for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Sources for Pleomorphic Rhabdomyosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet