Pleomorphic Rhabdomyosarcoma malady

MalaCards: Pleomorphic Rhabdomyosarcoma, also known as anaplastic rhabdomyosarcoma, is related to rhabdomyosarcoma and gallbladder sarcoma. An important gene associated with Pleomorphic Rhabdomyosarcoma is MYOG (myogenin (myogenic factor 4)), and among its related pathways are CDO in myogenesis and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds cysteine and amifostine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, skeletal muscle and uterus, and related mouse phenotypes are respiratory system and muscle.

Aliases & Descriptions:

pleomorphic rhabdomyosarcoma 6 43 anaplastic rhabdomyosarcoma 6 43

pleomorphic rhabdomyosarcoma, adult type 6 pleomorphic rhabdomyosarcoma (disorder) 6

Diseases related to pleomorphic rhabdomyosarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 148)

id	Related Disease	Score	Top Affiliating Genes
1	rhabdomyosarcoma	27.7	MUC16, PAX7, MYOD1, MYOG, MB, MYH3
2	gallbladder sarcoma	13.4	MYOG, MYOD1
3	pseudosarcomatous fibromatosis	13.3	DES, MYOG
4	ectomesenchymoma	13.3	PAX7, MYOD1
5	rhabdoid tumors	13.2	MYOD1, DES
6	myopathy congenital	13.2	MYOG, DES
7	meninges sarcoma	13.2	MB, DES
8	rhabdoid cancer	13.1	DES, MB
9	malignant mesenchymoma	13.1	MYOD1, DES, MYOG
10	mixed epithelial stromal tumour	13.1	MME, DES
11	mesenchymal chondrosarcoma	13.1	MYOG, MYOD1, DES
12	endometrial stromal tumor	13.1	MME, DES
13	adrenal cortical carcinoma	13.1	DES, TP53
14	ossifying fibromyxoid tumor	13.1	DES, MME
15	myoma	13.0	DES, MME
16	familial hypophosphatemia	13.0	MME, ALPPL2
17	pediatric cns embryonal cell carcinoma	13.0	MYOG, ALPPL2, MYOD1
18	cystic nephroma	13.0	MME, DES
19	breast metaplastic carcinoma	13.0	DES, TP53
20	endodermal sinus tumor	13.0	ALPPL2, MUC16
21	bile duct adenoma	13.0	DES, TP53
22	alveolar rhabdomyosarcoma	13.0	MYOG, DES, PAX7
23	endometrial stromal sarcoma	13.0	MME, DES
24	dysphagia	13.0	DES, MYH3
25	pleomorphic carcinoma	12.9	TP53, DES
26	myoepithelioma	12.9	TP53, DES
27	atypical teratoid rhabdoid tumor	12.9	DES, TP53
28	inclusion body myopathy	12.9	DES, MME
29	pigmented villonodular synovitis	12.9	MYOG, TP53, DES
30	duchenne muscular dystrophy	12.9	MYOD1, DES, MB
31	ossifying fibroma	12.9	MUC16, DES
32	fasciitis	12.8	TP53, MYOG, DES
33	adenofibroma	12.8	MUC16, MME
34	malignant peripheral nerve sheath tumor	12.8	TP53, DES, MYOG
35	fallopian tube carcinoma	12.8	MUC16, TP53
36	inclusion body myositis	12.8	DES, MME, MYOD1
37	ovarian mucinous neoplasm	12.8	MUC16, TP53
38	paralysis	12.8	MB, MYOD1, MYOG
39	sertoli-leydig cell tumor	12.7	DES, MUC16, MYOG
40	botryoid rhabdomyosarcoma	12.7	MYOG, MYOD1, PAX7, DES
41	peripheral primitive neuroectodermal tumor	12.7	PAX7, DES, MYOD1, MYOG
42	uterine fibroid	12.7	DES, MYOG, MUC16
43	giant cell tumor	12.7	DES, MYOG, TP53
44	chordoma	12.7	PAX7, TP53, DES
45	orbit rhabdomyosarcoma	12.7	TP53, MB, DES
46	adenosarcoma	12.7	MME, DES, MB
47	malignant fibroxanthoma	12.7	MB, TP53, DES
48	mixed cell type cancer	12.7	TP53, MB, DES
49	germ cell cancer	12.7	TP53, MYOG, MYOD1, ALPPL2
50	uterine sarcoma	12.7	DES, MME, MB

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pleomorphic rhabdomyosarcoma:

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MGI Mouse Phenotypes related to pleomorphic rhabdomyosarcoma:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.0	MYOG, MYOD1, PAX7, MB
2	muscle phenotype	MP:0005369	8.0	DES, TP53, MB, PAX7, MYOD1, MYOG
3	mortality/aging	MP:0010768	6.7	DES, TP53, MAPK3, MB, PAX7, MYOD1
4	homeostasis/metabolism phenotype	MP:0005376	6.3	EPHA3, DES, TP53, MAPK3, MB, MME

Articles related to pleomorphic rhabdomyosarcoma:

id	Title	Authors	Year	Affiliating Genes
1	Pleomorphic rhabdomyosarcoma showing smooth-muscle an d fibrohistiocytic differentiation: a single case report. (20070153)	Eyden B.	2010	MYOD1, MYOG
2	Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. (20173498)	Fadare O.... Parkash V.	2010	MME, ALPPL2, MYOD1
3	p53 mutation and loss have different effects on tumou rigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma. (20662002)	Doyle B.... Sansom O.J.	2010	TP53
4	Cytogenetic and real-time quantitative reverse-transc riptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma. (19480930)	Li G.... Endo N.	2009	MYOD1
5	Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice. (16785989)	Tsumura H.... Suzuki N.	2006	MAPK3
6	Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors. (16790082)	Goldstein M.... Orr-Urtreger A.	2006	EPHA3, PAX7
7	Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. (11406662)	Furlong M.A.... Fanburg-Smith J.C.	2001	MYH3
8	A new human pleomorphic rhabdomyosarcoma cell-line, HS-RMS-1, exhibiting MyoD1 and myogenin. (10853028)	Sonobe H.... Ohtsuki Y.	2000	MYOD1, MYOG
9	Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal woman with elevated serum CA125. (10479519)	Holcomb K.... Lee Y.C.	1999	MUC16
10	Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. (8333559)	Gaffney E.F.... Fletcher C.D.	1993	DES, MB

Genes related to pleomorphic rhabdomyosarcoma according to GeneCards:

(show all 12)

id	Symbol	Description	Score	GeneCards Section Context
1	MYOG	myogenin (myogenic factor 4)	11.0	Publications
2	ALPPL2	alkaline phosphatase, placental-like 2	11.0	Publications
3	MYOD1	myogenic differentiation 1	11.0	Publications
4	MYH3	myosin, heavy chain 3, skeletal muscle, embryonic	11.0	Publications
5	PAX7	paired box 7	11.0	Publications
6	DES	desmin	11.0	Publications
7	MUC16	mucin 16, cell surface associated	11.0	Publications
8	MME	membrane metallo-endopeptidase	11.0	Publications
9	MB	myoglobin	11.0	Publications
10	EPHA3	EPH receptor A3	11.0	Publications
11	MAPK3	mitogen-activated protein kinase 3	11.0	Publications
12	TP53	tumor protein p53	11.0	Publications

Pathways related to pleomorphic rhabdomyosarcoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	CDO in myogenesis38	9.8	MYOG, MYOD1
2	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.2	MME, MAPK3
3	ACE Inhibitor Pathway, Pharmacodynamics34	8.9	MME, MAPK3

Compounds related to pleomorphic rhabdomyosarcoma according to GeneDecks:

(show all 40)

id	Compound	Score	Top Affiliating Genes
1	cysteine32	10.1	MB, MYOG
2	amifostine32 9 9	11.9	ALPPL2, TP53
3	12-o-tetradecanoylphorbol 13-acetate32	9.8	MYOG, MYOD1, MME
4	retinoic acid32 42 18	11.8	MYOG, MYOD1, MME
5	estradiol32 9 18 9	12.8	EPHA3, DES
6	citrate32	9.3	MB, MME, MYOD1
7	fatty acid32	9.3	MYOG, MYOD1, MME, DES
8	c2ceramide32	9.2	MYOG, MAPK3, TP53
9	hyaluronic acid32 18	10.2	DES, MB, MUC16
10	geldanamycin32 9 9	11.1	TP53, MAPK3, MYOD1
11	oxygen32 18	10.1	EPHA3, MB, MYOD1, MYOG
12	actinomycin d32	9.1	DES, TP53, MME, MYOD1
13	steroid32	9.0	MYOG, MYOD1, MUC16, MME, DES
14	adriamycin32	9.0	MME, MB, TP53, DES
15	acetylcholine32 9 18 9	11.9	DES, MB, MME, MYOD1, MYOG
16	sodium nitroprusside32	8.9	MAPK3, MB, MME
17	olomoucine32 42 9 9	11.8	TP53, MAPK3
18	leucine32	8.8	MYOD1, MME, ALPPL2, EPHA3
19	sp 60012532 42	9.8	EPHA3, TP53, MAPK3
20	lactate32	8.8	DES, MB, MME, MUC16
21	ascorbic acid32 18	9.7	MAPK3, MB, MME, MYOG
22	resveratrol32 9 18 9	11.7	EPHA3, TP53, MAPK3
23	butyrate32	8.7	MYOG, MYOD1, MAPK3, ALPPL2, TP53
24	bromodeoxyuridine32	8.7	DES, MAPK3, MME, MYOD1, MYOG
25	melphalan32 9 9	10.6	TP53, MAPK3, MB, MUC16
26	doxorubicin32 34 9 9	11.6	DES, TP53, MB, MME, MUC16
27	creatinine32	8.5	DES, MB, MME, MUC16, MYOD1, MYOG
28	glucose32	8.4	EPHA3, DES, MME, MUC16, MYOD1, MYOG
29	cisplatin32 34 9 9	11.3	MUC16, MB, MAPK3, TP53
30	nitric oxide32 9 18 9	11.2	EPHA3, DES, MAPK3, MME, MYOG
31	threonine32	8.2	MYOD1, MUC16, MAPK3, DES, EPHA3
32	thymidine32 18	9.2	MME, MAPK3, TP53, DES
33	arginine32	7.8	DES, TP53, MAPK3, MB, MME, MYOD1
34	paraffin32	7.8	MYOG, DES, TP53, ALPPL2, MB, MME
35	tyrosine32	7.6	EPHA3, DES, MAPK3, MME, MUC16, MYOD1
36	h2o232	7.2	EPHA3, DES, TP53, MAPK3, MB, MME
37	testosterone32 9 18 9	10.1	EPHA3, DES, MAPK3, MB, MME, MUC16
38	estrogen32	7.1	EPHA3, DES, TP53, MAPK3, MME, MUC16
39	vegf32	6.6	EPHA3, DES, TP53, MAPK3, MB, MME
40	serine32	6.6	EPHA3, DES, TP53, MAPK3, MB, MME

Cellular components related to pleomorphic rhabdomyosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	myofibril	GO:030016	9.9	MYOD1, MYH3

Biological processes related to pleomorphic rhabdomyosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	muscle cell fate commitment	GO:042693	9.8	MYOG, MYOD1
2	skeletal muscle fiber development	GO:048741	9.6	MYOG, MYOD1
3	replicative senescence	GO:090399	9.5	MME, TP53