MCID: PLM030
MIFTS: 41

Pleomorphic Rhabdomyosarcoma

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Pleomorphic Rhabdomyosarcoma

MalaCards integrated aliases for Pleomorphic Rhabdomyosarcoma:

Name: Pleomorphic Rhabdomyosarcoma 12 55 14 69
Adult Pleomorphic Rhabdomyosarcoma 12 14 69
Pleomorphic Rhabdomyosarcoma, Adult Type 12
Anaplastic Rhabdomyosarcoma 12

Characteristics:

Orphanet epidemiological data:

55
pleomorphic rhabdomyosarcoma
Prevalence: <1/1000000 (Europe);

Classifications:



External Ids:

Disease Ontology 12 DOID:3250 DOID:8251
NCIt 46 C4258 C27369
SNOMED-CT 64 404054005 77455004
Orphanet 55 ORPHA293199
UMLS via Orphanet 70 C0334480
ICD10 via Orphanet 33 C49.9

Summaries for Pleomorphic Rhabdomyosarcoma

MalaCards based summary : Pleomorphic Rhabdomyosarcoma, also known as adult pleomorphic rhabdomyosarcoma, is related to histiocytoma and rhabdomyosarcoma. An important gene associated with Pleomorphic Rhabdomyosarcoma is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Neural Crest Differentiation and Transcriptional misregulation in cancer. The drugs Bevacizumab and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include uterus, endothelial and bone, and related phenotypes are muscle and embryo

Related Diseases for Pleomorphic Rhabdomyosarcoma

Diseases related to Pleomorphic Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 29.7 MB MYOD1
2 rhabdomyosarcoma 29.3 FOXO1 MB MYOD1 PAX3 PAX7
3 botryoid rhabdomyosarcoma 28.7 FOXO1 MB MYOD1 PAX3
4 rhabdomyosarcoma 2 27.8 FOXO1 MB MYOD1 PAX3 PAX7
5 childhood pleomorphic rhabdomyosarcoma 12.1
6 breast rhabdomyosarcoma 10.2 MB MYOD1
7 malignant triton tumor 10.2 MB MYOD1
8 mesenchymoma 10.2 MB MYOD1
9 spindle cell rhabdomyosarcoma 10.2 MB MYOD1
10 adult fibrosarcoma 10.2 MB MYOD1
11 medullomyoblastoma 10.1 MB MYOD1
12 malignant mesenchymoma 10.1 MB MYOD1
13 rhabdoid cancer 10.1 MB MYOD1
14 adenosarcoma 10.1 MB MME
15 mixed cell type cancer 10.1 MB MME
16 alveolar soft part sarcoma 10.1 MB MYOD1
17 nephrogenic adenofibroma 10.1 MME MYOD1
18 muscle tissue disease 10.1 MB MYOD1
19 uterine sarcoma 10.0 MB MME
20 laryngitis 10.0
21 childhood kidney cell carcinoma 9.9 FOXO1 PAX3
22 muscular dystrophy, duchenne type 9.9 MB MYOD1
23 inflammatory leiomyosarcoma 9.9 MYOD1 PAX7
24 conventional leiomyosarcoma 9.9 MYOD1 PAX7
25 endometrial stromal sarcoma 9.8 MB MME
26 colorectal cancer 9.8
27 aging 9.8
28 bile duct cysts 9.8
29 urinary tract infections, recurrent 9.8
30 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
31 thrombocytopenia 9.8
32 inguinal hernia 9.8
33 obstructive jaundice 9.8
34 melanoma 9.8
35 liposarcoma 9.8
36 fibrous histiocytoma 9.8
37 pancreatitis 9.8
38 pleomorphic liposarcoma 9.8
39 thyroiditis 9.8
40 mediastinitis 9.8
41 duodenitis 9.8
42 pulmonary embolism 9.8
43 cytomegalovirus infection 9.8
44 myositis 9.7 MB MYOD1
45 ewing sarcoma 9.5 FOXO1 MYOD1 PAX3
46 central nervous system mesenchymal non-meningothelial tumor 9.1 FOXO1 MYOD1 PAX3 PAX7
47 muscle cancer 8.8 FOXO1 MB MYOD1 PAX3 PAX7
48 embryonal rhabdomyosarcoma 8.8 FOXO1 MB MYOD1 PAX3 PAX7
49 skeletal muscle cancer 8.8 FOXO1 MB MYOD1 PAX3 PAX7

Graphical network of the top 20 diseases related to Pleomorphic Rhabdomyosarcoma:



Diseases related to Pleomorphic Rhabdomyosarcoma

Symptoms & Phenotypes for Pleomorphic Rhabdomyosarcoma

MGI Mouse Phenotypes related to Pleomorphic Rhabdomyosarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.65 PAX7 FOXO1 MB MYOD1 PAX3
2 embryo MP:0005380 9.62 PAX3 PAX7 FOXO1 MB
3 neoplasm MP:0002006 9.46 PAX3 PAX7 FOXO1 MYOD1
4 no phenotypic analysis MP:0003012 9.26 PAX3 PAX7 FOXO1 MYOD1
5 respiratory system MP:0005388 8.92 PAX3 PAX7 MB MYOD1

Drugs & Therapeutics for Pleomorphic Rhabdomyosarcoma

Drugs for Pleomorphic Rhabdomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Everolimus Approved Phase 2 159351-69-6 6442177
4
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
5
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
6
Vinblastine Approved Phase 2 865-21-4 241903 13342
7
Vinorelbine Approved, Investigational Phase 2 71486-22-1 44424639 60780
8 Alkylating Agents Phase 2
9 Angiogenesis Inhibitors Phase 2
10 Angiogenesis Modulating Agents Phase 2
11 Anti-Bacterial Agents Phase 2,Phase 1
12 Antibiotics, Antitubercular Phase 2,Phase 1
13 Antibodies Phase 2,Phase 1
14 Antibodies, Monoclonal Phase 2,Phase 1
15 Antifungal Agents Phase 2
16 Anti-Infective Agents Phase 2
17 Antimitotic Agents Phase 2
18 Antineoplastic Agents, Phytogenic Phase 2
19 Antirheumatic Agents Phase 2
20 Endothelial Growth Factors Phase 2
21 Immunoglobulins Phase 2,Phase 1
22 Immunosuppressive Agents Phase 2
23 Mitogens Phase 2
24
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
25
Doxil Approved June 1999 Phase 1 31703
26 Topoisomerase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vinorelbine Tartrate and Cyclophosphamide in Combination With Bevacizumab or Temsirolimus in Treating Patients With Recurrent or Refractory Rhabdomyosarcoma Completed NCT01222715 Phase 2 Cyclophosphamide;Temsirolimus;Vinorelbine Tartrate
2 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
3 Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery Recruiting NCT03009201 Phase 1 Doxorubicin;Ribociclib

Search NIH Clinical Center for Pleomorphic Rhabdomyosarcoma

Genetic Tests for Pleomorphic Rhabdomyosarcoma

Anatomical Context for Pleomorphic Rhabdomyosarcoma

MalaCards organs/tissues related to Pleomorphic Rhabdomyosarcoma:

38
Uterus, Endothelial, Bone, Kidney, Skeletal Muscle, Heart, Skin

Publications for Pleomorphic Rhabdomyosarcoma

Articles related to Pleomorphic Rhabdomyosarcoma:

(show top 50) (show all 91)
# Title Authors Year
1
Successful treatment of adult pleomorphic rhabdomyosarcoma with bone invasion in the lower leg by chemotherapy and biological reconstruction: A case report. ( 28356215 )
2017
2
Temozolomide combined with irinotecan caused regression in an adult pleomorphic rhabdomyosarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. ( 29100276 )
2017
3
Pleomorphic rhabdomyosarcoma infiltrating thoracic spine in a 59-year-old female patient: Case report. ( 28868225 )
2017
4
Primary cutaneous pleomorphic rhabdomyosarcoma in the periocular region. ( 29282833 )
2017
5
Pleomorphic Rhabdomyosarcoma of the Uterus - Case Report and a Systematic Review of the Literature. ( 28476820 )
2017
6
Primary Pleomorphic Rhabdomyosarcoma of Thyroid Gland in an Adult Patient: A Case Report. ( 27026769 )
2016
7
Pleomorphic rhabdomyosarcoma arising in the anterior mediastinum: A case report with cytological features of imprint and liquid-based cytology specimens. ( 28024111 )
2016
8
Pleomorphic Rhabdomyosarcoma Arising from True Vocal Fold of Larynx: Report of a Rare Case and Literature Review. ( 27699075 )
2016
9
Pleomorphic rhabdomyosarcoma with an impressive response to chemotherapy: case report and review of the literature. ( 26952562 )
2016
10
Misdiagnosis of primary pleomorphic rhabdomyosarcoma of the right thigh in a young adult: A case report. ( 27588141 )
2016
11
Case of pleomorphic rhabdomyosarcoma arising on subcutaneous tissue in an adult patient: Review of the published works of 13 cases arising on cutaneous or subcutaneous tissue. ( 27569112 )
2016
12
Pleomorphic rhabdomyosarcoma of the left atrium mimicking myxoma. ( 27510683 )
2016
13
Adult Pleomorphic Rhabdomyosarcoma: A Multicentre Retrospective Study. ( 26504053 )
2015
14
Pancreatic pleomorphic rhabdomyosarcoma. ( 26092712 )
2015
15
Pelvic pleomorphic rhabdomyosarcoma presenting as oliguria in a 61-year-old woman. ( 25880675 )
2015
16
Rapidly growing massive pleomorphic rhabdomyosarcoma of the bladder presenting with bladder outlet obstruction. ( 26381078 )
2015
17
Adult Duodenal Pleomorphic Rhabdomyosarcoma. ( 26157890 )
2014
18
Cutaneous Pleomorphic Rhabdomyosarcoma Occurring on Sun Damaged Skin: A Case Report. ( 25140666 )
2014
19
Primary pleomorphic rhabdomyosarcoma of the adrenal gland in an adult: A case report. ( 24348835 )
2014
20
Pleomorphic rhabdomyosarcoma of the cerebellopontine angle in an adult: a review of literature. ( 24481021 )
2014
21
Pleomorphic Rhabdomyosarcoma Presenting as a Hypopharyngeal Mass. ( 25243978 )
2014
22
Primary pleomorphic rhabdomyosarcoma of breast: Report of a rare neoplasm. ( 25709664 )
2014
23
Paratesticular pleomorphic rhabdomyosarcoma: a report of two cases. ( 23476881 )
2013
24
Postradiation cutaneous pleomorphic rhabdomyosarcoma with extracellular collagen deposits reminiscent of so-called amianthoid fibers. ( 24341853 )
2013
25
Pleomorphic rhabdomyosarcoma in a patient with hereditary nonpolyposis colorectal cancer. ( 23319697 )
2013
26
Multiple sites of highly amplified DNA sequences detected by molecular cytogenetic analysis in HS-RMS-2, a new pleomorphic rhabdomyosarcoma cell line. ( 22432055 )
2012
27
Pleomorphic rhabdomyosarcoma with pulmonary tumour embolism. ( 23203178 )
2012
28
A pleomorphic rhabdomyosarcoma mimicking an inguinal hernia: a case report and review of the literature. ( 22611365 )
2012
29
Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. ( 23002204 )
2012
30
Uterine pleomorphic rhabdomyosarcoma: a case report and review of literature. ( 21476391 )
2011
31
Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. ( 20173498 )
2010
32
Pleomorphic rhabdomyosarcoma of the uterine corpus--a case report. ( 20825058 )
2010
33
Electrochemotherapy treatment for bilateral pleomorphic rhabdomyosarcoma in a cat. ( 20492454 )
2010
34
Touch preparation of primary uterine pleomorphic rhabdomyosarcoma: report of a case with clinical cytopathologic features. ( 21053592 )
2010
35
Pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation: a single case report. ( 20070153 )
2010
36
A rare case of paratesticular pleomorphic rhabdomyosarcoma diagnosed by fine needle aspiration: a case report. ( 19790247 )
2010
37
p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma. ( 20662002 )
2010
38
Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma. ( 19480930 )
2009
39
Primary pleomorphic rhabdomyosarcoma of trunk in an adolescent. ( 19317765 )
2009
40
Pleomorphic rhabdomyosarcoma pulmonary embolism. ( 19713348 )
2009
41
Surgical management of an inoperable giant pleomorphic rhabdomyosarcoma of the chest wall. ( 19704344 )
2009
42
Primary mediastinal pleomorphic rhabdomyosarcoma: a case report. ( 18287801 )
2008
43
Primary pleomorphic rhabdomyosarcoma of the kidney in an adult. ( 18621001 )
2008
44
A rare tumor of the diaphragm: pleomorphic rhabdomyosarcoma. ( 18442596 )
2008
45
A case of extremely chemoresistant pure pleomorphic rhabdomyosarcoma of the uterus associated with a high serum LDH level. ( 19051826 )
2008
46
Laryngeal pleomorphic rhabdomyosarcoma. ( 17481838 )
2007
47
Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. ( 17630111 )
2007
48
Palpebral pleomorphic rhabdomyosarcoma in a teenager. ( 16946759 )
2007
49
Botryoid-type pleomorphic rhabdomyosarcoma of the renal pelvis in an adult. A rare case report and review of the literature. ( 16825824 )
2006
50
Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors. ( 16790082 )
2006

Variations for Pleomorphic Rhabdomyosarcoma

Expression for Pleomorphic Rhabdomyosarcoma

Search GEO for disease gene expression data for Pleomorphic Rhabdomyosarcoma.

Pathways for Pleomorphic Rhabdomyosarcoma

GO Terms for Pleomorphic Rhabdomyosarcoma

Biological processes related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.5 FOXO1 MYOD1 PAX3
2 anatomical structure morphogenesis GO:0009653 9.37 FOXO1 PAX7
3 cellular response to starvation GO:0009267 9.26 FOXO1 MYOD1
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.26 FOXO1 MYOD1 PAX3 PAX7
5 skeletal muscle tissue development GO:0007519 9.16 MYOD1 PAX7
6 muscle organ development GO:0007517 8.8 MYOD1 PAX3 PAX7

Molecular functions related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding transcription factor activity GO:0003700 9.26 FOXO1 MYOD1 PAX3 PAX7
2 sequence-specific DNA binding GO:0043565 8.92 FOXO1 MYOD1 PAX3 PAX7

Sources for Pleomorphic Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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