MCID: PLM030
MIFTS: 49

Pleomorphic Rhabdomyosarcoma malady

Cancer diseases, Rare diseases categories
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Summaries for Pleomorphic Rhabdomyosarcoma

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MalaCards: Pleomorphic Rhabdomyosarcoma, also known as anaplastic rhabdomyosarcoma, is related to rhabdomyosarcoma and colorectal cancer. An important gene associated with Pleomorphic Rhabdomyosarcoma is MYH3 (myosin, heavy chain 3, skeletal muscle, embryonic), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Thyroid cancer. The compounds olomoucine and sodium nitroprusside have been mentioned in the context of this disorder. Affiliated tissues include uterus, heart and skeletal muscle, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Aliases & Classifications for Pleomorphic Rhabdomyosarcoma

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8Disease Ontology, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 49 
Rare tumors


Characteristics (Orphanet epidemiological data):

49
pleomorphic rhabdomyosarcoma:
Prevalence: <1/1000000


Aliases & Descriptions:

pleomorphic rhabdomyosarcoma 8 49 62
anaplastic rhabdomyosarcoma 8 62
pleomorphic rhabdomyosarcoma, adult type 8


External Ids:

Disease Ontology8 DOID:3250
NCIt40 C4258
SNOMED-CT via Orphanet59 404054005, 77455004
SNOMED-CT58 404054005, 77455004
UMLS via Orphanet63 C0334480
ICD10 via Orphanet26 C49.9

Related Diseases for Pleomorphic Rhabdomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Pleomorphic Rhabdomyosarcoma family:

Adult Pleomorphic Rhabdomyosarcoma

Diseases related to Pleomorphic Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma31.4TP53, DES, PAX7, MB, MYOD1, MYOG
2colorectal cancer30.3EPHA3, TP53, MAPK3
3liposarcoma30.2TP53, DES, MB
4alveolar rhabdomyosarcoma30.2PAX7, MYOD1, MYOG, DES, MB
5melanoma29.9TP53, MB, DES, MAPK3, MME, MYOD1
6laryngitis10.4
7adult pleomorphic rhabdomyosarcoma10.3
8childhood pleomorphic rhabdomyosarcoma10.3
9choledochal cyst10.1
10obstructive jaundice10.1
11fibrous histiocytoma10.1
12pleomorphic liposarcoma10.1
13botryoid rhabdomyosarcoma10.1
14histiocytoma10.1
15mediastinitis10.1
16pulmonary embolism10.1
17thrombocytopenia10.1
18cytomegalovirus infection10.1
19malignant mesenchymoma10.1MYOG, MYOD1
20pseudosarcomatous fibromatosis10.1DES, MYOG
21alveolar soft part sarcoma10.1MYOD1, MB
22myositis10.1MB, MYOD1
23rhabdoid tumor10.1DES, MYOD1
24myopathy congenital10.1MYOG, DES
25granular cell tumor10.1MB, DES
26adenofibroma10.1MUC16
27endometrial stromal sarcoma10.1MME, DES
28embryonal cancer10.1ALPPL2, MYOD1, MYOG
29smooth muscle tumor10.1MME, DES
30malignant fibroxanthoma10.1TP53, MB
31myotonic dystrophy10.1MYOG, MYOD1
32neuropathy10.0MYOG, MYOD1, MB
33duchenne muscular dystrophy10.0MYOD1, DES, MB
34leiomyoma10.0DES, MME, MYOG
35neuromuscular disease10.0DES, MB
36endodermal sinus tumor10.0MUC16, ALPPL2
37uterine sarcoma10.0DES, MB, MME
38adenosarcoma10.0MME, MB, DES
39peripheral primitive neuroectodermal tumor10.0MYOD1, PAX7, MYOG, DES
40malignant mixed mullerian tumor10.0MB, DES, TP53
41fibroma10.0MUC16, DES
42cholangiocarcinoma10.0ALPPL2, MME, TP53
43abrikosov's tumor10.0DES, MUC16
44wilms tumor10.0MYOG, MYOD1, DES, MME
45uterine fibroid10.0DES, MYOG, MUC16
46medulloblastoma10.0DES, TP53, MAPK3
47factor vii deficiency10.0MUC16, MB
48hypertrophy of breast10.0EPHA3, MYOD1, MYOG
49lung benign neoplasm10.0MAPK3, MME, TP53
50b-cell lymphomas10.0TP53, MME, MAPK3

Graphical network of the top 20 diseases related to Pleomorphic Rhabdomyosarcoma:



Diseases related to pleomorphic rhabdomyosarcoma

Symptoms for Pleomorphic Rhabdomyosarcoma

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Drugs & Therapeutics for Pleomorphic Rhabdomyosarcoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Pleomorphic Rhabdomyosarcoma

Genetic Tests for Pleomorphic Rhabdomyosarcoma

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Anatomical Context for Pleomorphic Rhabdomyosarcoma

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33MalaCards
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MalaCards organs/tissues related to Pleomorphic Rhabdomyosarcoma:

33
Uterus, Heart, Skeletal muscle, Kidney, Bone, Smooth muscle, Liver, Salivary gland, Adrenal gland

Animal Models for Pleomorphic Rhabdomyosarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pleomorphic Rhabdomyosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7MAPK3, MYOD1, PAX7, TP53
2MP:00053857.9DES, TP53, EPHA3, MYOD1, MAPK3, MB
3MP:00053867.8DES, TP53, PAX7, EPHA3, MYOG, MAPK3
4MP:00053697.7DES, TP53, PAX7, MYOD1, MYOG, MAPK3
5MP:00053887.6MB, TP53, PAX7, EPHA3, MYOD1, MYOG
6MP:00053767.2DES, TP53, EPHA3, MYOD1, MYOG, MME
7MP:00107687.2DES, TP53, PAX7, EPHA3, MYOD1, MYOG

Publications for Pleomorphic Rhabdomyosarcoma

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52PubMed
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Articles related to Pleomorphic Rhabdomyosarcoma:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Pleomorphic rhabdomyosarcoma in a patient with hereditary nonpolyposis colorectal cancer. (23319697)
2013
2
A pleomorphic rhabdomyosarcoma mimicking an inguinal hernia: a case report and review of the literature. (22611365)
2012
3
Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. (23002204)
2012
4
Pleomorphic rhabdomyosarcoma with pulmonary tumour embolism. (23203178)
2012
5
Multiple sites of highly amplified DNA sequences detected by molecular cytogenetic analysis in HS-RMS-2, a new pleomorphic rhabdomyosarcoma cell line. (22432055)
2012
6
Uterine pleomorphic rhabdomyosarcoma: a case report and review of literature. (21476391)
2011
7
Touch preparation of primary uterine pleomorphic rhabdomyosarcoma: report of a case with clinical cytopathologic features. (21053592)
2010
8
A rare case of paratesticular pleomorphic rhabdomyosarcoma diagnosed by fine needle aspiration: a case report. (19790247)
2010
9
Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. (20173498)
2010
10
Pleomorphic rhabdomyosarcoma of the uterine corpus--a case report. (20825058)
2010
11
Electrochemotherapy treatment for bilateral pleomorphic rhabdomyosarcoma in a cat. (20492454)
2010
12
Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma. (19480930)
2009
13
Primary pleomorphic rhabdomyosarcoma of trunk in an adolescent. (19317765)
2009
14
A rare tumor of the diaphragm: pleomorphic rhabdomyosarcoma. (18442596)
2008
15
Primary pleomorphic rhabdomyosarcoma of the kidney in an adult. (18621001)
2008
16
A case of extremely chemoresistant pure pleomorphic rhabdomyosarcoma of the uterus associated with a high serum LDH level. (19051826)
2008
17
Primary mediastinal pleomorphic rhabdomyosarcoma: a case report. (18287801)
2008
18
Laryngeal pleomorphic rhabdomyosarcoma. (17481838)
2007
19
Palpebral pleomorphic rhabdomyosarcoma in a teenager. (16946759)
2007
20
Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. (17630111)
2007
21
Pleomorphic rhabdomyosarcoma within a choledochal cyst; a rare cause of obstructive jaundice. (16967793)
2006
22
Unusual manifestations of disseminated neoplasia at presentation: right-sided heart failure due to a massive cardiac metastasis and autoimmune thrombocytopenia in pleomorphic rhabdomyosarcoma of the adult. (16462513)
2006
23
Botryoid-type pleomorphic rhabdomyosarcoma of the renal pelvis in an adult. A rare case report and review of the literature. (16825824)
2006
24
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal patient. (16799711)
2006
25
Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors. (16790082)
2006
26
Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice. (16785989)
2006
27
Pleomorphic rhabdomyosarcoma of the diaphragm. (15719879)
2005
28
Paratesticular pleomorphic rhabdomyosarcoma in an adult. (15787340)
2004
29
Pleomorphic rhabdomyosarcoma of the anterior abdominal wall following multimodality treatment for carcinoma of the rectum. (15173925)
2004
30
Pleomorphic rhabdomyosarcoma with pulmonary metastasis in a stranded Steller (northern) sea lion (Eumetopias jubatus). (15003477)
2004
31
Primary pleomorphic rhabdomyosarcoma of the kidney in adults: unusual tumor]. (14650305)
2003
32
Microsatellite instability in a pleomorphic rhabdomyosarcoma in a patient with hereditary non-polyposis colorectal cancer. (12940783)
2003
33
Pleomorphic rhabdomyosarcoma in an adult forearm: a case report. (11810631)
2002
34
Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. (11406662)
2001
35
Pleomorphic rhabdomyosarcoma of the uterine corpus: a case report. (11446473)
2001
36
Pleomorphic rhabdomyosarcoma in children: four cases in the pediatric age group. (11510002)
2001
37
Unusual second malignancies following radiation therapy: subcutaneous pleomorphic rhabdomyosarcoma and cutaneous melanoma. Two case reports. (10955690)
2000
38
A new human pleomorphic rhabdomyosarcoma cell-line, HS-RMS-1, exhibiting MyoD1 and myogenin. (10853028)
2000
39
Uterine pleomorphic rhabdomyosarcoma in a patient receiving tamoxifen therapy. (10600318)
1999
40
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal woman with elevated serum CA125. (10479519)
1999
41
Laryngeal pleomorphic rhabdomyosarcoma. (9693927)
1998
42
A rare paratesticular pleomorphic rhabdomyosarcoma. (7656365)
1995
43
Pleomorphic rhabdomyosarcoma of the heart metastatic to bone. Report of a case with fine needle aspiration biopsy findings. (7762352)
1995
44
Pleomorphic rhabdomyosarcoma arising in association with the right pulmonary artery. (7979918)
1994
45
Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. (8333559)
1993
46
Pleomorphic rhabdomyosarcoma of the urinary bladder in association with recurrent urinary-tract infection. (2703059)
1989
47
Rapid remission of a large pleomorphic rhabdomyosarcoma with radiation and a novel schedule of simultaneous high-dose cisplatin. (2623385)
1989
48
Electron microscopic study of pleomorphic rhabdomyosarcoma of adult skeletal muscle. (6677005)
1983
49
Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. (223963)
1979
50
Pleomorphic rhabdomyosarcoma of the uvula--report of a case and review of the literature. (4773903)
1973

Variations for Pleomorphic Rhabdomyosarcoma

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Expression for genes affiliated with Pleomorphic Rhabdomyosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleomorphic Rhabdomyosarcoma

Search GEO for disease gene expression data for Pleomorphic Rhabdomyosarcoma.

Pathways for genes affiliated with Pleomorphic Rhabdomyosarcoma

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50PathCards, 51PharmGKB, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN
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Pathways related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8MAPK3, MME
29.6TP53, MAPK3
39.6MAPK3, TP53
49.6MYOD1, PAX7
59.4TP53, MYOD1
69.3MYOG, MYOD1
7
Show member pathways
9.3MYOG, MYOD1
8
Show member pathways
Alzheimers Disease38
9.3TP53, MME, MAPK3
9
Show member pathways
8.7MAPK3, MYH3, EPHA3, TP53, DES

Compounds for genes affiliated with Pleomorphic Rhabdomyosarcoma

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45Novoseek, 11DrugBank, 24HMDB, 61Tocris Bioscience, 51PharmGKB, 29IUPHAR
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Compounds related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1olomoucine45 1110.8TP53, MAPK3
2sodium nitroprusside459.8MB, MAPK3, MME
3phorbol 12,13-dibutyrate459.8MAPK3, EPHA3
4b 723459.7MUC16, DES
5hyaluronic acid45 2410.6MB, DES, MUC16
6sp 60012545 6110.6TP53, EPHA3, MAPK3
7resveratrol45 61 24 1112.6MAPK3, EPHA3, TP53
8c2ceramide459.5TP53, MAPK3, MYOG
9adriamycin459.5MME, TP53, DES, MB
10citrate459.5MYOD1, MME, MB
11amifostine45 1110.5ALPPL2, TP53
12geldanamycin45 51 61 1112.4TP53, MAPK3, MYOD1
13radicicol45 61 1111.3MAPK3, TP53
14lactate459.3MB, DES, MUC16, MME
15thymidine45 2410.3DES, MAPK3, MME, TP53
16n acetylcysteine459.3TP53, MAPK3, MB
17ascorbic acid45 2410.3MB, MME, MAPK3, MYOG
18estradiol45 24 1111.2EPHA3, MUC16, DES, MAPK3
19adenylate459.2MME, MB, DES, MYOG
20melphalan45 51 1111.2MUC16, TP53, MAPK3, MB
21actinomycin d459.1MYOD1, DES, TP53, MME
22cisplatin45 51 61 1112.1MB, MAPK3, MUC16, TP53
23progesterone45 29 61 24 1113.1MME, TP53, DES, MUC16
24fatty acid459.0DES, MYOD1, MME, MYOG
25doxorubicin45 51 1111.0TP53, DES, MUC16, MB, MME
26nitric oxide45 24 1110.9EPHA3, MME, MAPK3, MYOG, DES
27acetylcholine45 51 29 24 1112.8MYOD1, DES, MYOG, MB, MME
28bromodeoxyuridine458.8MAPK3, DES, MYOD1, MYOG, MME
2912-o-tetradecanoylphorbol 13-acetate458.8MYOD1, MME, MYOG, DES, MAPK3
30oligonucleotide458.7MYOG, TP53, MYOD1, PAX7
31threonine458.6MAPK3, MYOD1, EPHA3, DES, MUC16
32phosphatidylinositol458.6MYOD1, EPHA3, MME, MAPK3
33cyclic amp45 249.6MYOD1, MAPK3, ALPPL2, DES
34steroid458.6MUC16, MME, MYOG, MYOD1, DES
35leucine458.6MME, MYOD1, ALPPL2, EPHA3
36arginine458.5TP53, MAPK3, MB, MME, DES, MYOD1
37oxygen45 249.4EPHA3, MYOD1, DES, MME, MB, MYOG
38creatinine458.3MB, MME, MUC16, DES, MYOD1, MYOG
39retinoic acid45 249.3MAPK3, MYOD1, MYOG, MME, TP53, DES
40h2o2458.2MME, MUC16, MAPK3, EPHA3, MB, DES
41glucose458.2MYOG, MYOD1, MUC16, MME, EPHA3, DES
42butyrate458.1MYOG, ALPPL2, MAPK3, MYOD1, TP53
43calcium45 51 24 1111.1DES, MAPK3, MYOD1, MME, MYOG, EPHA3
44cysteine458.0MYOD1, MME, MB, MAPK3, MYOG, EPHA3
45tyrosine457.8MAPK3, MME, MUC16, MYOD1, EPHA3, DES
46testosterone45 61 24 1110.5MYOD1, MYOG, EPHA3, DES, MB, MME
47estrogen457.4TP53, EPHA3, MYOG, MUC16, MME, MAPK3
48vegf457.1TP53, MYOG, DES, EPHA3, MYOD1, MUC16
49serine457.1MB, DES, MME, MYOG, MYOD1, EPHA3
50paraffin457.0ALPPL2, MME, MUC16, MYOG, MYOD1, DES

GO Terms for genes affiliated with Pleomorphic Rhabdomyosarcoma

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16Gene Ontology
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Biological processes related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.9MME, TP53
2muscle filament slidingGO:0300499.8MYH3, DES
3sensory perception of painGO:0192339.8MAPK3, MME
4positive regulation of cell cycle arrestGO:0711589.6MYOG, TP53
5muscle cell fate commitmentGO:0426939.6MYOD1, MYOG
6skeletal muscle fiber developmentGO:0487419.5MYOG, MYOD1
7cellular response to estradiol stimulusGO:0713929.5MYOD1, MYOG
8positive regulation of muscle cell differentiationGO:0511499.4MYOG, MYOD1
9muscle cell differentiationGO:0426929.3MYOD1, MYOG
10skeletal muscle tissue developmentGO:0075199.0MYOG, MYOD1
11positive regulation of transcription from RNA polymerase II promoterGO:0459448.4MAPK3, MYOG, MYOD1, PAX7, TP53

Molecular functions related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0012289.5MYOG, TP53
2core promoter bindingGO:0010479.3MYOG, MYOD1
3chromatin DNA bindingGO:0314909.2MYOG, MYOD1
4E-box bindingGO:0708889.0MYOG, MYOD1

Products for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Sources for Pleomorphic Rhabdomyosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet