MCID: PLM030
MIFTS: 42

Pleomorphic Rhabdomyosarcoma malady

Cancer diseases, Rare diseases categories

Aliases & Classifications for Pleomorphic Rhabdomyosarcoma

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Sources:
8Disease Ontology, 48Orphanet, 61UMLS, 56SNOMED-CT, 39NCIt, 26ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Pleomorphic Rhabdomyosarcoma:

Name: Pleomorphic Rhabdomyosarcoma 8 48 61
Anaplastic Rhabdomyosarcoma 8 61
 
Pleomorphic Rhabdomyosarcoma, Adult Type 8


Classifications:

Orphanet: 48 
Rare tumors


Characteristics (Orphanet epidemiological data):

48
pleomorphic rhabdomyosarcoma:
Prevalence: <1/1000000 (Europe)


External Ids:

Disease Ontology8 DOID:3250
NCIt39 C4258
Orphanet48 293199
SNOMED-CT56 77455004, 404054005
ICD10 via Orphanet26 C49.9
UMLS via Orphanet62 C0334480

Summaries for Pleomorphic Rhabdomyosarcoma

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MalaCards based summary: Pleomorphic Rhabdomyosarcoma, also known as anaplastic rhabdomyosarcoma, is related to rhabdomyosarcoma and liposarcoma. An important gene associated with Pleomorphic Rhabdomyosarcoma is MYH3 (myosin, heavy chain 3, skeletal muscle, embryonic), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Thyroid cancer. The compounds olomoucine and sodium nitroprusside have been mentioned in the context of this disorder. Affiliated tissues include uterus, heart and skeletal muscle, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Related Diseases for Pleomorphic Rhabdomyosarcoma

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Diseases in the Pleomorphic Rhabdomyosarcoma family:

Adult Pleomorphic Rhabdomyosarcoma

Diseases related to Pleomorphic Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma31.2DES, TP53, PAX7, MYOD1, MYOG, MB
2liposarcoma30.3MB, TP53, DES
3colorectal cancer30.0TP53, EPHA3, MAPK3
4melanoma28.9DES, TP53, PAX7, EPHA3, MYOD1, MME
5malignant mesenchymoma10.4MYOD1, MYOG
6myoma10.4DES, MYOG
7adult pleomorphic rhabdomyosarcoma10.4
8childhood pleomorphic rhabdomyosarcoma10.4
9laryngitis10.4
10pseudosarcomatous fibromatosis10.4MYOG, DES
11alveolar soft-part sarcoma10.4MYOD1, MB
12myositis10.3MB, MYOD1
13rhabdoid tumor10.3MYOD1, DES
14myopathy congenital10.3MYOG, DES
15granular cell tumor10.3DES, MB
16adenofibroma10.3MUC16
17endometrial stromal sarcoma10.3DES, MME
18embryonal cancer10.3MYOD1, MYOG, ALPPL2
19smooth muscle tumor10.2MME, DES
20malignant fibroxanthoma10.2TP53, MB
21neuropathy10.2MB, MYOG, MYOD1
22duchenne muscular dystrophy10.2MB, MYOD1, DES
23leiomyoma10.2DES, MYOG, MME
24neuromuscular disease10.2MB, DES
25thrombocytopenia10.1
26choledochal cyst10.1
27obstructive jaundice10.1
28fibrous histiocytoma10.1
29pleomorphic liposarcoma10.1
30botryoid rhabdomyosarcoma10.1
31histiocytoma10.1
32mediastinitis10.1
33pulmonary embolism10.1
34cytomegalovirus infection10.1
35endodermal sinus tumor10.1ALPPL2, MUC16
36uterine sarcoma10.1MB, MME, DES
37adenosarcoma10.1DES, MME, MB
38ewing sarcoma10.1MYOG, MYOD1, PAX7, DES
39malignant mixed mullerian tumor10.1MB, TP53, DES
40fibroma10.1MUC16, DES
41myotonic dystrophy10.1MYOG, MYOD1
42cholangiocarcinoma10.1TP53, MME, ALPPL2
43wilms tumor10.1MME, MYOG, MYOD1, DES
44abrikosov's tumor10.1DES, MUC16
45uterine fibroid10.0DES, MYOG, MUC16
46medulloblastoma10.0DES, TP53, MAPK3
47factor vii deficiency10.0MB, MUC16
48lung benign neoplasm10.0MAPK3, MME, TP53
49b-cell lymphomas10.0MAPK3, MME, TP53
50rhabdomyosarcoma 2, alveolar9.9DES, PAX7, MYOD1, MYOG, MB

Graphical network of the top 20 diseases related to Pleomorphic Rhabdomyosarcoma:



Diseases related to pleomorphic rhabdomyosarcoma

Symptoms for Pleomorphic Rhabdomyosarcoma

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Drugs & Therapeutics for Pleomorphic Rhabdomyosarcoma

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Drug clinical trials:

Search ClinicalTrials for Pleomorphic Rhabdomyosarcoma

Search NIH Clinical Center for Pleomorphic Rhabdomyosarcoma

Genetic Tests for Pleomorphic Rhabdomyosarcoma

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Anatomical Context for Pleomorphic Rhabdomyosarcoma

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MalaCards organs/tissues related to Pleomorphic Rhabdomyosarcoma:

31
Uterus, Heart, Skeletal muscle, Kidney, Bone, Smooth muscle, Liver, Salivary gland, Adrenal gland, Breast, Skin

Animal Models for Pleomorphic Rhabdomyosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Rhabdomyosarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7MAPK3, MYOD1, PAX7, TP53
2MP:00053857.9DES, TP53, EPHA3, MYOD1, MAPK3, MB
3MP:00053867.8DES, TP53, PAX7, EPHA3, MYOG, MAPK3
4MP:00053697.7DES, TP53, PAX7, MYOD1, MYOG, MAPK3
5MP:00053887.6MB, TP53, PAX7, EPHA3, MYOD1, MYOG
6MP:00053767.2DES, TP53, EPHA3, MYOD1, MYOG, MME
7MP:00107687.2DES, TP53, PAX7, EPHA3, MYOD1, MYOG

Publications for Pleomorphic Rhabdomyosarcoma

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Articles related to Pleomorphic Rhabdomyosarcoma:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Pelvic pleomorphic rhabdomyosarcoma presenting as oliguria in a 61-year-old woman. (25880675)
2015
2
Cutaneous Pleomorphic Rhabdomyosarcoma Occurring on Sun Damaged Skin: A Case Report. (25140666)
2014
3
Pleomorphic rhabdomyosarcoma of the cerebellopontine angle in an adult: a review of literature. (24481021)
2014
4
Pleomorphic rhabdomyosarcoma in a patient with hereditary nonpolyposis colorectal cancer. (23319697)
2013
5
A pleomorphic rhabdomyosarcoma mimicking an inguinal hernia: a case report and review of the literature. (22611365)
2012
6
Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. (23002204)
2012
7
Pleomorphic rhabdomyosarcoma with pulmonary tumour embolism. (23203178)
2012
8
Multiple sites of highly amplified DNA sequences detected by molecular cytogenetic analysis in HS-RMS-2, a new pleomorphic rhabdomyosarcoma cell line. (22432055)
2012
9
Uterine pleomorphic rhabdomyosarcoma: a case report and review of literature. (21476391)
2011
10
Touch preparation of primary uterine pleomorphic rhabdomyosarcoma: report of a case with clinical cytopathologic features. (21053592)
2010
11
A rare case of paratesticular pleomorphic rhabdomyosarcoma diagnosed by fine needle aspiration: a case report. (19790247)
2010
12
Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. (20173498)
2010
13
Pleomorphic rhabdomyosarcoma of the uterine corpus--a case report. (20825058)
2010
14
Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma. (19480930)
2009
15
Primary pleomorphic rhabdomyosarcoma of trunk in an adolescent. (19317765)
2009
16
A rare tumor of the diaphragm: pleomorphic rhabdomyosarcoma. (18442596)
2008
17
Primary pleomorphic rhabdomyosarcoma of the kidney in an adult. (18621001)
2008
18
A case of extremely chemoresistant pure pleomorphic rhabdomyosarcoma of the uterus associated with a high serum LDH level. (19051826)
2008
19
Primary mediastinal pleomorphic rhabdomyosarcoma: a case report. (18287801)
2008
20
Laryngeal pleomorphic rhabdomyosarcoma. (17481838)
2007
21
Palpebral pleomorphic rhabdomyosarcoma in a teenager. (16946759)
2007
22
Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. (17630111)
2007
23
Pleomorphic rhabdomyosarcoma within a choledochal cyst; a rare cause of obstructive jaundice. (16967793)
2006
24
Unusual manifestations of disseminated neoplasia at presentation: right-sided heart failure due to a massive cardiac metastasis and autoimmune thrombocytopenia in pleomorphic rhabdomyosarcoma of the adult. (16462513)
2006
25
Botryoid-type pleomorphic rhabdomyosarcoma of the renal pelvis in an adult. A rare case report and review of the literature. (16825824)
2006
26
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal patient. (16799711)
2006
27
Pleomorphic rhabdomyosarcoma of the diaphragm. (15719879)
2005
28
Paratesticular pleomorphic rhabdomyosarcoma in an adult. (15787340)
2004
29
Pleomorphic rhabdomyosarcoma of the anterior abdominal wall following multimodality treatment for carcinoma of the rectum. (15173925)
2004
30
Pleomorphic rhabdomyosarcoma with pulmonary metastasis in a stranded Steller (northern) sea lion (Eumetopias jubatus). (15003477)
2004
31
Primary pleomorphic rhabdomyosarcoma of the kidney in adults: unusual tumor]. (14650305)
2003
32
Microsatellite instability in a pleomorphic rhabdomyosarcoma in a patient with hereditary non-polyposis colorectal cancer. (12940783)
2003
33
Pleomorphic rhabdomyosarcoma in an adult forearm: a case report. (11810631)
2002
34
Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. (11406662)
2001
35
Pleomorphic rhabdomyosarcoma of the uterine corpus: a case report. (11446473)
2001
36
Unusual second malignancies following radiation therapy: subcutaneous pleomorphic rhabdomyosarcoma and cutaneous melanoma. Two case reports. (10955690)
2000
37
A new human pleomorphic rhabdomyosarcoma cell-line, HS-RMS-1, exhibiting MyoD1 and myogenin. (10853028)
2000
38
Uterine pleomorphic rhabdomyosarcoma in a patient receiving tamoxifen therapy. (10600318)
1999
39
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal woman with elevated serum CA125. (10479519)
1999
40
Laryngeal pleomorphic rhabdomyosarcoma. (9693927)
1998
41
A rare paratesticular pleomorphic rhabdomyosarcoma. (7656365)
1995
42
Pleomorphic rhabdomyosarcoma of the heart metastatic to bone. Report of a case with fine needle aspiration biopsy findings. (7762352)
1995
43
Identification of a spontaneous pleomorphic rhabdomyosarcoma in the thoracic and abdominal cavities of a female Wistar rat. (7725603)
1995
44
Pleomorphic rhabdomyosarcoma arising in association with the right pulmonary artery. (7979918)
1994
45
Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. (8333559)
1993
46
Pleomorphic rhabdomyosarcoma of the urinary bladder in association with recurrent urinary-tract infection. (2703059)
1989
47
Rapid remission of a large pleomorphic rhabdomyosarcoma with radiation and a novel schedule of simultaneous high-dose cisplatin. (2623385)
1989
48
Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. (223963)
1979
49
Pleomorphic rhabdomyosarcoma of the larynx. A case report and review of the literature. (956708)
1976
50
Pleomorphic rhabdomyosarcoma of the uvula--report of a case and review of the literature. (4773903)
1973

Variations for Pleomorphic Rhabdomyosarcoma

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Expression for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Search GEO for disease gene expression data for Pleomorphic Rhabdomyosarcoma.

Pathways for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Pathways related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8MAPK3, MME
29.6TP53, MAPK3
39.6MAPK3, TP53
49.6MYOD1, PAX7
59.4TP53, MYOD1
69.3MYOG, MYOD1
7
Show member pathways
9.3MYOG, MYOD1
8
Show member pathways
Alzheimers Disease36
9.3TP53, MME, MAPK3
9
Show member pathways
8.7MAPK3, MYH3, EPHA3, TP53, DES

Compounds for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Compounds related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1olomoucine44 1110.8TP53, MAPK3
2sodium nitroprusside449.8MB, MAPK3, MME
3phorbol 12,13-dibutyrate449.8MAPK3, EPHA3
4b 723449.7MUC16, DES
5hyaluronic acid44 2410.6MB, DES, MUC16
6sp 60012544 6010.6TP53, EPHA3, MAPK3
7resveratrol44 60 24 1112.6MAPK3, EPHA3, TP53
8c2ceramide449.5TP53, MAPK3, MYOG
9adriamycin449.5MME, TP53, DES, MB
10citrate449.5MYOD1, MME, MB
11amifostine44 1110.5ALPPL2, TP53
12geldanamycin44 50 60 1112.4TP53, MAPK3, MYOD1
13radicicol44 60 1111.3MAPK3, TP53
14lactate449.3MB, DES, MUC16, MME
15thymidine44 2410.3DES, MAPK3, MME, TP53
16n acetylcysteine449.3TP53, MAPK3, MB
17ascorbic acid44 2410.3MB, MME, MAPK3, MYOG
18estradiol44 24 1111.2EPHA3, MUC16, DES, MAPK3
19adenylate449.2MME, MB, DES, MYOG
20melphalan44 50 1111.2MUC16, TP53, MAPK3, MB
21actinomycin d449.1MYOD1, DES, TP53, MME
22cisplatin44 50 60 1112.1MB, MAPK3, MUC16, TP53
23progesterone44 28 60 24 1113.1MME, TP53, DES, MUC16
24fatty acid449.0DES, MYOD1, MME, MYOG
25doxorubicin44 50 1111.0TP53, DES, MUC16, MB, MME
26nitric oxide44 24 1110.9EPHA3, MME, MAPK3, MYOG, DES
27acetylcholine44 50 28 24 1112.8MYOD1, DES, MYOG, MB, MME
28bromodeoxyuridine448.8MAPK3, DES, MYOD1, MYOG, MME
2912-o-tetradecanoylphorbol 13-acetate448.8MYOD1, MME, MYOG, DES, MAPK3
30oligonucleotide448.7MYOG, TP53, MYOD1, PAX7
31threonine448.6MAPK3, MYOD1, EPHA3, DES, MUC16
32phosphatidylinositol448.6MYOD1, EPHA3, MME, MAPK3
33cyclic amp44 249.6MYOD1, MAPK3, ALPPL2, DES
34steroid448.6MUC16, MME, MYOG, MYOD1, DES
35leucine448.6MME, MYOD1, ALPPL2, EPHA3
36arginine448.5TP53, MAPK3, MB, MME, DES, MYOD1
37oxygen44 249.4EPHA3, MYOD1, DES, MME, MB, MYOG
38creatinine448.3MB, MME, MUC16, DES, MYOD1, MYOG
39retinoic acid44 249.3MAPK3, MYOD1, MYOG, MME, TP53, DES
40h2o2448.2MME, MUC16, MAPK3, EPHA3, MB, DES
41glucose448.2MYOG, MYOD1, MUC16, MME, EPHA3, DES
42butyrate448.1MYOG, ALPPL2, MAPK3, MYOD1, TP53
43calcium44 50 24 1111.1DES, MAPK3, MYOD1, MME, MYOG, EPHA3
44cysteine448.0MYOD1, MME, MB, MAPK3, MYOG, EPHA3
45tyrosine447.8MAPK3, MME, MUC16, MYOD1, EPHA3, DES
46testosterone44 60 24 1110.5MYOD1, MYOG, EPHA3, DES, MB, MME
47estrogen447.4TP53, EPHA3, MYOG, MUC16, MME, MAPK3
48vegf447.1TP53, MYOG, DES, EPHA3, MYOD1, MUC16
49serine447.1MB, DES, MME, MYOG, MYOD1, EPHA3
50paraffin447.0ALPPL2, MME, MUC16, MYOG, MYOD1, DES

GO Terms for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Biological processes related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:00903999.9MME, TP53
2muscle filament slidingGO:00300499.8MYH3, DES
3sensory perception of painGO:00192339.8MAPK3, MME
4positive regulation of cell cycle arrestGO:00711589.6MYOG, TP53
5muscle cell fate commitmentGO:00426939.6MYOD1, MYOG
6skeletal muscle fiber developmentGO:00487419.5MYOG, MYOD1
7cellular response to estradiol stimulusGO:00713929.5MYOD1, MYOG
8positive regulation of muscle cell differentiationGO:00511499.4MYOG, MYOD1
9muscle cell differentiationGO:00426929.3MYOD1, MYOG
10skeletal muscle tissue developmentGO:00075199.0MYOG, MYOD1
11positive regulation of transcription from RNA polymerase II promoterGO:00459448.4MAPK3, MYOG, MYOD1, PAX7, TP53

Molecular functions related to Pleomorphic Rhabdomyosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:00012289.5MYOG, TP53
2core promoter bindingGO:00010479.3MYOG, MYOD1
3chromatin DNA bindingGO:00314909.2MYOG, MYOD1
4E-box bindingGO:00708889.0MYOG, MYOD1

Sources for Pleomorphic Rhabdomyosarcoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet