MCID: PLM030
MIFTS: 47

Pleomorphic Rhabdomyosarcoma malady

Cancer diseases category

Summaries for Pleomorphic Rhabdomyosarcoma

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32MalaCards
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MalaCards: Pleomorphic Rhabdomyosarcoma, also known as anaplastic rhabdomyosarcoma, is related to rhabdomyosarcoma and colorectal cancer. An important gene associated with Pleomorphic Rhabdomyosarcoma is MYH3 (myosin, heavy chain 3, skeletal muscle, embryonic), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Thyroid cancer. The compounds glucose and sodium nitroprusside have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and skeletal muscle, and related mouse phenotypes are muscle and cardiovascular system.

Aliases & Classifications for Pleomorphic Rhabdomyosarcoma

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8Disease Ontology, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
pleomorphic rhabdomyosarcoma:
Prevalence: <1/1000000


Aliases & Descriptions:

pleomorphic rhabdomyosarcoma 8 48 60
anaplastic rhabdomyosarcoma 8 60
pleomorphic rhabdomyosarcoma, adult type 8


External Ids:

Disease Ontology8 DOID:3250
NCIt39 C4258
SNOMED-CT56 404054005, 77455004
SNOMED-CT via Orphanet57 404054005, 77455004
ICD10 via Orphanet26 C49.9

Related Diseases for Pleomorphic Rhabdomyosarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pleomorphic Rhabdomyosarcoma family:

Adult Pleomorphic Rhabdomyosarcoma

Diseases related to Pleomorphic Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma31.4TP53, PAX7, MYOG, MYOD1, DES, MB
2colorectal cancer30.3TP53, ALPPL2, MUC16
3alveolar rhabdomyosarcoma30.3MB, DES, MYOD1, MYOG, PAX7
4liposarcoma30.1MB, DES, TP53
5embryonal rhabdomyosarcoma30.1MB, DES, MYOD1, MYOG, PAX7
6melanoma30.0MB, DES, MAPK3, MYOD1, EPHA3, MME
7adult pleomorphic rhabdomyosarcoma10.7
8laryngitis10.3
9adult botryoid rhabdomyosarcoma10.2
10childhood pleomorphic rhabdomyosarcoma10.2
11botryoid rhabdomyosarcoma10.2
12pulmonary embolism10.2
13obstructive jaundice10.1
14fibrous histiocytoma10.1
15pleomorphic carcinoma10.1
16pleomorphic liposarcoma10.1
17rectum rhabdomyosarcoma10.1
18liver rhabdomyosarcoma10.1
19choledochal cyst10.1
20histiocytoma10.1
21mediastinitis10.1
22thrombocytopenia10.1
23teratoma10.0ALPPL2
24angiomyolipoma10.0DES
25chondrosarcoma10.0DES
26pancreatitis10.0ALPPL2
27fibrosarcoma10.0DES
28chordoma10.0DES
29cystadenoma10.0MME
30glomerulonephritis10.0MME
31myeloma10.0ALPPL2
32malignant mesenchymoma10.0MYOG, MYOD1
33kidney cancer10.0TP53
34seminoma10.0ALPPL2
35bladder carcinoma10.0TP53
36nephroblastoma10.0TP53
37rhabdoid tumor10.0DES, MYOD1
38adrenocortical carcinoma10.0TP53
39pseudosarcomatous fibromatosis10.0MYOG, DES
40ductal carcinoma in situ10.0TP53
41alveolar soft part sarcoma10.0MYOD1, MB
42gastrointestinal stromal tumor10.0DES
43smooth muscle tumor10.0DES, MME
44myositis10.0MYOD1, MB
45endometriosis10.0MUC16
46myopathy congenital10.0DES, MYOG
47congestive heart failure10.0MME
48endometrial stromal sarcoma10.0DES, MME
49cervical adenocarcinoma10.0MUC16
50malignant fibroxanthoma10.0MYOG, MYOD1, DES

Graphical network of the top 20 diseases related to Pleomorphic Rhabdomyosarcoma:



Diseases related to pleomorphic rhabdomyosarcoma

Clinical Features for Pleomorphic Rhabdomyosarcoma

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Drugs & Therapeutics for Pleomorphic Rhabdomyosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pleomorphic Rhabdomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Rhabdomyosarcoma

Search NIH Clinical Center for Pleomorphic Rhabdomyosarcoma

Search CenterWatch for Pleomorphic Rhabdomyosarcoma

Genetic Tests for Pleomorphic Rhabdomyosarcoma

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Anatomical Context for Pleomorphic Rhabdomyosarcoma

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32MalaCards
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MalaCards organs/tissues related to Pleomorphic Rhabdomyosarcoma:

32
Uterus, Cervix, Skeletal muscle, Heart, Kidney, Liver, Smooth muscle, Salivary gland, Adrenal gland, Bone

Animal Models for Pleomorphic Rhabdomyosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pleomorphic Rhabdomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4MB, MAPK3, MYOD1, PAX7, TP53
2MP:00053858.0DES, MAPK3, MYOD1, EPHA3, TP53, MB
3MP:00053887.5TP53, PAX7, EPHA3, MYOG, MYOD1, MAPK3
4MP:00053767.1MB, DES, MAPK3, MYOD1, MYOG, EPHA3
5MP:00107686.8MB, DES, MAPK3, MYOD1, MYOG, EPHA3

Publications for Pleomorphic Rhabdomyosarcoma

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50PubMed
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Articles related to Pleomorphic Rhabdomyosarcoma:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Primary pleomorphic rhabdomyosarcoma of the adrenal gland in an adult: A case report. (24348835)
2014
2
Pleomorphic rhabdomyosarcoma in a patient with hereditary nonpolyposis colorectal cancer. (23319697)
2013
3
Postradiation cutaneous pleomorphic rhabdomyosarcoma with extracellular collagen deposits reminiscent of so-called amianthoid fibers. (24341853)
2013
4
Paratesticular pleomorphic rhabdomyosarcoma: a report of two cases. (23476881)
2013
5
A pleomorphic rhabdomyosarcoma mimicking an inguinal hernia: a case report and review of the literature. (22611365)
2012
6
Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. (23002204)
2012
7
Pleomorphic rhabdomyosarcoma with pulmonary tumour embolism. (23203178)
2012
8
Multiple sites of highly amplified DNA sequences detected by molecular cytogenetic analysis in HS-RMS-2, a new pleomorphic rhabdomyosarcoma cell line. (22432055)
2012
9
Uterine pleomorphic rhabdomyosarcoma: a case report and review of literature. (21476391)
2011
10
Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma. (21316601)
2011
11
A rare case of paratesticular pleomorphic rhabdomyosarcoma diagnosed by fine needle aspiration: a case report. (19790247)
2010
12
Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. (20173498)
2010
13
Pleomorphic rhabdomyosarcoma of the uterine corpus--a case report. (20825058)
2010
14
p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma. (20662002)
2010
15
Pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation: a single case report. (20070153)
2010
16
Primary pleomorphic rhabdomyosarcoma of trunk in an adolescent. (19317765)
2009
17
Pleomorphic rhabdomyosarcoma pulmonary embolism. (19713348)
2009
18
Surgical management of an inoperable giant pleomorphic rhabdomyosarcoma of the chest wall. (19704344)
2009
19
A rare tumor of the diaphragm: pleomorphic rhabdomyosarcoma. (18442596)
2008
20
A case of extremely chemoresistant pure pleomorphic rhabdomyosarcoma of the uterus associated with a high serum LDH level. (19051826)
2008
21
Primary mediastinal pleomorphic rhabdomyosarcoma: a case report. (18287801)
2008
22
Laryngeal pleomorphic rhabdomyosarcoma. (17481838)
2007
23
Palpebral pleomorphic rhabdomyosarcoma in a teenager. (16946759)
2007
24
Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. (17630111)
2007
25
Embryonal rhabdomyosarcoma of the cervix with focal pleomorphic areas. (17213352)
2007
26
Botryoid-type pleomorphic rhabdomyosarcoma of the renal pelvis in an adult. A rare case report and review of the literature. (16825824)
2006
27
Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal patient. (16799711)
2006
28
Pleomorphic rhabdomyosarcoma of the diaphragm. (15719879)
2005
29
Adult paravertebral pleomorphic rhabdomyosarcoma infiltrating diffusely the whole spinal axis. Case report. (15796361)
2005
30
Pleomorphic rhabdomyosarcoma of the anterior abdominal wall following multimodality treatment for carcinoma of the rectum. (15173925)
2004
31
Anaplastic (pleomorphic) subtype embryonal rhabdomyosarcoma of the cervix. (12942264)
2004
32
Primary pleomorphic rhabdomyosarcoma of the kidney in adults: unusual tumor]. (14650305)
2003
33
Microsatellite instability in a pleomorphic rhabdomyosarcoma in a patient with hereditary non-polyposis colorectal cancer. (12940783)
2003
34
Pleomorphic rhabdomyosarcoma of the uterine corpus: a case report. (11446473)
2001
35
Pleomorphic rhabdomyosarcoma in a cow. (11217054)
2001
36
Unusual second malignancies following radiation therapy: subcutaneous pleomorphic rhabdomyosarcoma and cutaneous melanoma. Two case reports. (10955690)
2000
37
A new human pleomorphic rhabdomyosarcoma cell-line, HS-RMS-1, exhibiting MyoD1 and myogenin. (10853028)
2000
38
Laryngeal pleomorphic rhabdomyosarcoma. (9693927)
1998
39
Pleomorphic rhabdomyosarcoma of the submandibular salivary gland. (9141408)
1997
40
Laryngeal pleomorphic rhabdomyosarcoma. A critical review of the literature. (8604891)
1996
41
Pleomorphic rhabdomyosarcoma of the heart metastatic to bone. Report of a case with fine needle aspiration biopsy findings. (7762352)
1995
42
Identification of a spontaneous pleomorphic rhabdomyosarcoma in the thoracic and abdominal cavities of a female Wistar rat. (7725603)
1995
43
Pleomorphic rhabdomyosarcoma arising in association with the right pulmonary artery. (7979918)
1994
44
Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. (8333559)
1993
45
Pleomorphic rhabdomyosarcoma of the urinary bladder in association with recurrent urinary-tract infection. (2703059)
1989
46
Electron microscopic study of pleomorphic rhabdomyosarcoma of adult skeletal muscle. (6677005)
1983
47
Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. (223963)
1979
48
Pleomorphic Rhabdomyosarcoma: response to irradiation. (1135403)
1975
49
Pleomorphic rhabdomyosarcoma of the uvula--report of a case and review of the literature. (4773903)
1973
50
Pleomorphic rhabdomyosarcoma of the gingiva. Report of a case. (5249509)
1969

Genetic Variations for Pleomorphic Rhabdomyosarcoma

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Expression for genes affiliated with Pleomorphic Rhabdomyosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleomorphic Rhabdomyosarcoma

Search GEO for disease gene expression data for Pleomorphic Rhabdomyosarcoma.

Pathways for genes affiliated with Pleomorphic Rhabdomyosarcoma

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49PharmGKB, 29KEGG, 51QIAGEN
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Pathways related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8MME, MAPK3
29.6TP53, MAPK3
3
Hide members
8.7TP53, EPHA3, MYH3, MAPK3, DES

Compounds for genes affiliated with Pleomorphic Rhabdomyosarcoma

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1glucose449.8MUC16, MYOG
2sodium nitroprusside449.7MME, MAPK3, MB
3fatty acid449.6MYOG, MYOD1
4olomoucine44 1110.5TP53, MAPK3
5sp 60012544 5910.5TP53, EPHA3, MAPK3
6resveratrol44 59 11 2412.5MAPK3, EPHA3, TP53
7adriamycin449.5MB, DES, MME, TP53
8c2ceramide449.5TP53, MYOG, MAPK3
9amifostine44 1110.5TP53, ALPPL2
10hyaluronic acid44 2410.4MUC16, DES, MB
11citrate449.4MME, MYOD1, MB
12geldanamycin44 49 59 1112.4TP53, MYOD1, MAPK3
13ascorbic acid44 2410.3MB, MAPK3, MYOG, MME
14lactate449.2MB, DES, MUC16, MME
15thymidine44 2410.2DES, MAPK3, MME, TP53
16melphalan44 1110.2TP53, MUC16, MAPK3, MB
17estradiol44 11 2411.2DES, MAPK3, MUC16, EPHA3
18actinomycin d449.1DES, MYOD1, MME, TP53
19creatinine449.1MB, MYOD1, MUC16, MME
20adenylate449.0MB, DES, MYOG, MME
21doxorubicin44 49 1111.0MB, DES, MUC16, MME, TP53
22cisplatin44 49 59 1112.0MB, MAPK3, MUC16, TP53
23progesterone44 59 28 11 2412.9TP53, MME, MUC16, DES
24nitric oxide44 11 2410.9DES, MAPK3, MYOG, EPHA3, MME
25acetylcholine44 49 28 11 2412.8MME, MYOG, MYOD1, DES, MB
26bromodeoxyuridine448.8DES, MAPK3, MYOD1, MYOG, MME
2712-o-tetradecanoylphorbol 13-acetate448.8DES, MAPK3, MYOD1, MYOG, MME
28threonine448.6DES, MAPK3, MYOD1, MUC16, EPHA3
29steroid448.6DES, MYOD1, MYOG, MUC16, MME
30arginine448.5MB, DES, MAPK3, MYOD1, MME, TP53
31leucine448.4MYOD1, EPHA3, MME, ALPPL2
32oxygen44 249.4MB, DES, MYOD1, MYOG, EPHA3, MME
33retinoic acid44 249.3DES, MAPK3, MYOD1, MYOG, MME, TP53
34h2o2448.2MB, DES, MAPK3, MUC16, EPHA3, MME
35butyrate448.1MAPK3, MYOD1, MYOG, ALPPL2, TP53
36cyclic amp44 249.1DES, MAPK3, MYOD1, ALPPL2
37cysteine448.0MB, DES, MAPK3, MYOD1, MYOG, EPHA3
38tyrosine447.8DES, MAPK3, MYOD1, MYOG, MUC16, EPHA3
39testosterone44 59 11 2410.5MB, DES, MAPK3, MYOD1, MYOG, MUC16
40estrogen447.4DES, MAPK3, MYOD1, MYOG, MUC16, EPHA3
41vegf447.1MB, DES, MAPK3, MYOD1, MYOG, MUC16
42serine447.1MB, DES, MAPK3, MYOD1, MYOG, MUC16
43paraffin447.0TP53, MB, DES, MYOD1, MYOG, MUC16

GO Terms for genes affiliated with Pleomorphic Rhabdomyosarcoma

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16Gene Ontology
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Cellular components related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myofibrilGO:0300169.6MYOD1, MYH3

Biological processes related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.8TP53, MME
2muscle cell fate commitmentGO:0426939.5MYOG, MYOD1
3positive regulation of cell cycle arrestGO:0711589.4TP53, MYOG
4skeletal muscle fiber developmentGO:0487419.4MYOD1, MYOG
5cellular response to estradiol stimulusGO:0713929.3MYOG, MYOD1
6phosphorylationGO:0163109.3ALPPL2, MAPK3
7positive regulation of muscle cell differentiationGO:0511499.0MYOG, MYOD1
8positive regulation of transcription from RNA polymerase II promoterGO:0459448.3MAPK3, MYOD1, MYOG, PAX7, TP53

Molecular functions related to Pleomorphic Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positiGO:0012289.5TP53, MYOG
2E-box bindingGO:0708889.3MYOG, MYOD1
3chromatin DNA bindingGO:0314909.2MYOG, MYOD1
4core promoter bindingGO:0010479.0MYOG, MYOD1

Products for genes affiliated with Pleomorphic Rhabdomyosarcoma

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Sources for Pleomorphic Rhabdomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet