PXA
MCID: PLM020
MIFTS: 48

Pleomorphic Xanthoastrocytoma (PXA) malady

Neuronal, Cancer categories

Summaries for Pleomorphic Xanthoastrocytoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Pleomorphic Xanthoastrocytoma is a neoplasm of the brain that occurs often in children and teenagers.... more...

MalaCards: Pleomorphic Xanthoastrocytoma, also known as PXA, is related to ganglioglioma and astrocytoma. An important gene associated with Pleomorphic Xanthoastrocytoma is SYP (synaptophysin), and among its related pathways are Small cell lung cancer and Development IGF-RI signaling. The compounds estrogen and vincristine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and cerebellum, and related mouse phenotypes are embryogenesis and renal/urinary system.

Aliases & Classifications for Pleomorphic Xanthoastrocytoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 49Orphanet, 61UMLS, 40NCIt, 57SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
pleomorphic xanthoastrocytoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pleomorphic xanthoastrocytoma 8 43 49 61
pxa 43 49
pleomorphic xantho-astrocytoma 8


External Ids:

Disease Ontology8 DOID:4852
SNOMED-CT57 189924002, 78838008
NCIt40 C4323

Related Diseases for Pleomorphic Xanthoastrocytoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pleomorphic Xanthoastrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1ganglioglioma31.0TUBB, SYP, GFAP, TSC1
2astrocytoma30.7TP53, TSC1, GFAP, CDK4, CDKN2B, CDKN2A
3giant cell glioblastoma30.5GFAP, EGFR, MDM2
4atypical teratoid rhabdoid tumor30.3SMARCB1
5dysembryoplastic neuroepithelial tumor30.3SYP
6fibrous histiocytoma30.3CD34
7rhabdoid tumor30.3SYP, SMARCB1
8pilocytic astrocytoma30.2TSC1, GFAP, CDK4, SYP, MGMT
9anaplastic oligodendroglioma30.2MDM2, MGMT, EGFR, CDKN2A, GFAP, CDK4
10anaplastic astrocytoma30.2TP53, GFAP, CDK4, CDKN2B, CDKN2A, EGFR
11neurofibromatosis10.6
12arteriovenous malformation10.3
13moyamoya disease10.2
14temporal lobe epilepsy10.2
15desmoplastic infantile ganglioglioma10.2
16sturge-weber syndrome10.2
17weber syndrome10.2
18glomus tumor10.0SYP
19chordoma10.0GFAP
20gliomatosis cerebri10.0GFAP
21angiomyolipoma10.0TSC1
22gastrointestinal stromal tumor10.0CD34
23wilms tumor10.0SMARCB1
24choroid plexus carcinoma10.0SMARCB1
25ganglioneuroblastoma10.0SYP
26gemistocytic astrocytoma10.0GFAP
27synovial sarcoma10.0CD34
28mycosis fungoides10.0CDKN2B
29angiosarcoma10.0CD34
30skin melanoma10.0CDKN2B
31leiomyoma10.0CD34
32plasma cell leukemia10.0CDK4
33kaposi's sarcoma10.0CD34
34medulloepithelioma10.0SYP
35melanotic neuroectodermal tumor10.0SYP
36uterine sarcoma10.0MDM2
37peutz-jeghers syndrome10.0TSC1
38cervical adenocarcinoma10.0CDKN2A
39dermatofibrosarcoma10.0MDM2
40merkel cell carcinoma10.0SYP
41hemangioblastoma10.0GFAP, SYP
42hemangioma10.0CD34, CD68
43spitz nevus10.0BRAF
44leukoplakia10.0MGMT
45biliary tract cancer10.0EGFR
46fibromatosis10.0CD34
47pineocytoma10.0GFAP, SYP
48teratoma10.0SMARCB1, GFAP
49gliosarcoma10.0CDK4, GFAP
50pineoblastoma10.0GFAP, SYP

Graphical network of the top 20 diseases related to Pleomorphic Xanthoastrocytoma:



Diseases related to pleomorphic xanthoastrocytoma

Clinical Features for Pleomorphic Xanthoastrocytoma

Drugs & Therapeutics for Pleomorphic Xanthoastrocytoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pleomorphic Xanthoastrocytoma

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Xanthoastrocytoma

Search NIH Clinical Center for Pleomorphic Xanthoastrocytoma

Search CenterWatch for Pleomorphic Xanthoastrocytoma

Genetic Tests for Pleomorphic Xanthoastrocytoma

Anatomical Context for Pleomorphic Xanthoastrocytoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Pleomorphic Xanthoastrocytoma:

33
Spinal cord, Brain, Cerebellum, Retina, Parietal lobe, Temporal lobe, Pineal

Animal Models for Pleomorphic Xanthoastrocytoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pleomorphic Xanthoastrocytoma:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.4TSC1
2MP:00053679.9TSC1, EGFR
3MP:00036319.7TSC1, GFAP, CDK4, SYP
4MP:00053919.6EGFR, GFAP, SMARCB1
5MP:00053909.1CD68, TSC1
6MP:00053798.7MGMT, CDKN2A, CDKN2B, CDK4, TP53
7MP:00053898.7BRAF, EGFR, CDKN2A, CDKN2B, TSC1, TP53
8MP:00053768.5MGMT, CDK4, CD34, GFAP, TSC1, SMARCB1
9MP:00053698.5BRAF, MDM2, CDKN2A, CDK4, GFAP, TSC1
10MP:00107718.4MDM2, CDKN2A, CDKN2B, CDK4, CD34, TSC1
11MP:00053708.2BRAF, MDM2, EGFR, CDKN2A, CDK4, TSC1
12MP:00053818.1BRAF, MDM2, EGFR, CDKN2A, CDK4, GFAP
13MP:00053857.8BRAF, MDM2, EGFR, CDK4, GFAP, TSC1
14MP:00053787.6MDM2, EGFR, CDKN2A, CDK4, GFAP, TSC1
15MP:00030127.4MGMT, MDM2, EGFR, SYP, CDKN2A, CD68
16MP:00053847.1BRAF, MDM2, EGFR, CDKN2A, CDKN2B, CDK4
17MP:00107686.9BRAF, MGMT, MDM2, EGFR, CDKN2A, CDKN2B
18MP:00053976.8BRAF, MDM2, EGFR, CDKN2A, CD68, CDKN2B
19MP:00020066.8TP53, BRAF, MGMT, MDM2, EGFR, CDKN2A
20MP:00053876.6CDKN2A, EGFR, MDM2, BRAF, CD68, CDKN2B

Publications for Pleomorphic Xanthoastrocytoma

Sources:
51PubMed
See all sources

Articles related to Pleomorphic Xanthoastrocytoma:

(show top 50)    (show all 190)
idTitleAuthorsYear
1
Pleomorphic xanthoastrocytoma: magnetic resonance imaging findings in a series of cases with histopathological confirmation. (23249973)
2013
2
Nonanaplastic Pleomorphic Xanthoastrocytoma with Meningeal Dissemination Presenting with Bilateral Visual Loss. (23701304)
2013
3
Cerebral pleomorphic xanthoastrocytoma associated with NF1: an updated review with a rare atypical case from Africa. (22020543)
2012
4
Patterns of care and outcomes of patients with pleomorphic xanthoastrocytoma: a SEER analysis. (22843450)
2012
5
Pleomorphic xanthoastrocytoma: an atypical astrocytoma. (22755386)
2012
6
Pleomorphic xanthoastrocytoma - a clinico-pathological review. (22101999)
2011
7
Pleomorphic xanthoastrocytoma and moyamoya disease in a patient with neurofibromatosis type 1 - case report - . (21515957)
2011
8
Assessment of MGMT promoter methylation status in pleomorphic xanthoastrocytoma. (21626073)
2011
9
Pleomorphic xanthoastrocytoma: MR imaging findings in 19 patients. (21498352)
2011
10
Cerebrospinal fluid cytologic findings of a pleomorphic xanthoastrocytoma: a case report. (21053559)
2010
11
Pleomorphic xanthoastrocytoma presenting with life-threatening hemorrhage in a child. (19278318)
2009
12
Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation. (19164434)
2009
13
Pleomorphic xanthoastrocytoma in elderly patients may portend a poor prognosis. (18255294)
2008
14
Pleomorphic xanthoastrocytoma: a comparative pathological study between conventional and anaplastic types. (18184267)
2008
15
Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma. (17431546)
2007
16
A neuroepithelial tumor showing combined histological features of dysembryoplastic neuroepithelial tumor and pleomorphic xanthoastrocytoma--a case report and review of the literature. (17702498)
2007
17
Non-anaplastic pleomorphic xanthoastrocytoma with neuroradiological evidences of leptomeningeal dissemination. (16369851)
2006
18
Pleomorphic xanthoastrocytoma of the cerebellopontine angle in a child. (17047968)
2006
19
A case of pleomorphic xanthoastrocytoma presenting with massive tumoral hemorrhage. (15690134)
2005
20
Cerebellar pleomorphic xanthoastrocytoma in a patient with neurofibromatosis type 1. (15289955)
2004
21
Expression of the CD34 antigen in pleomorphic xanthoastrocytomas. (12624789)
2003
22
Molecular genetic analysis of anaplastic pleomorphic xanthoastrocytoma. (12732498)
2003
23
Expression of macrophage/histiocytic antigens in pleomorphic xanthoastrocytomas. (12899201)
2003
24
Malignant transformation of pleomorphic xanthoastrocytoma: case report. (12715030)
2003
25
Genetic imbalances in pleomorphic xanthoastrocytoma detected by comparative genomic hybridization and literature review. (11801302)
2002
26
Positron emission tomography in three children with pleomorphic xanthoastrocytoma. (12269732)
2002
27
Immunophenotype of pleomorphic xanthoastrocytoma. (11914626)
2002
28
Intrasellar pleomorphic xanthoastrocytoma: case report. (12234421)
2002
29
The use of chemotherapy to facilitate surgical resection in pleomorphic xanthoastrocytoma: experience in a single case. (11585332)
2001
30
Pigmented pleomorphic xanthoastrocytoma: report of a rare case with review of the literature. (11371237)
2001
31
Pleomorphic xanthoastrocytoma with predominantly exophytic growth: case report. (11750009)
2001
32
Pleomorphic xanthoastrocytoma of the cerebellum. (11048750)
2000
33
Cerebellar pleomorphic xanthoastrocytoma in an infant. (10504553)
1999
34
Pleomorphic xanthoastrocytoma: what do we really know about it? (10223246)
1999
35
Angiomatous pleomorphic xanthoastrocytoma as a component of ganglioglioma. (17337987)
1999
36
Malignant transformation in pleomorphic xanthoastrocytoma--a report of two cases. (10627788)
1999
37
Squash cytology of pleomorphic xanthoastrocytoma mimicking glioblastoma. A case report. (10432890)
1999
38
PCR detection of JC virus DNA in the brain tissue of a 9-year-old child with pleomorphic xanthoastrocytoma. (9584961)
1998
39
Pleomorphic xanthoastrocytoma. (9009492)
1996
40
Divergent differentiation in pleomorphic xanthoastrocytoma. Evidence for a neuronal element and possible relationship to ganglion cell tumors. (8540612)
1996
41
Delayed occurrence of cerebellar pleomorphic xanthoastrocytoma after supratentorial pleomorphic xanthoastrocytoma removal. Case report. (7815113)
1995
42
Pleomorphic xanthoastrocytoma associated with von Recklinghausen neurofibromatosis. (8481944)
1993
43
Pleomorphic xanthoastrocytoma. (8498232)
1993
44
Pleomorphic xanthoastrocytoma: an immunohistochemical study of three cases. (1563714)
1992
45
Temporal lobe tumor demonstrating ganglioglioma and pleomorphic xanthoastrocytoma components. Case report. (1607956)
1992
46
Pleomorphic xanthoastrocytoma: some new observations. (1335384)
1992
47
MRI of temporal lobe pleomorphic xanthoastrocytoma. (1385498)
1992
48
Test and teach. Number Sixty-four. Diagnosis: Pleomorphic xanthoastrocytoma. (2091002)
1990
49
Pleomorphic xanthoastrocytoma: report of two cases. (3352896)
1988
50
A variant of cerebral glioma called pleomorphic xanthoastrocytoma: case report. (4000446)
1985

Genetic Variations for Pleomorphic Xanthoastrocytoma

Expression for genes affiliated with Pleomorphic Xanthoastrocytoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pleomorphic Xanthoastrocytoma

Search GEO for disease gene expression data for Pleomorphic Xanthoastrocytoma.

Pathways for genes affiliated with Pleomorphic Xanthoastrocytoma

Sources:
30KEGG, 12EMD Millipore, 52QIAGEN, 38NCBI BioSystems Database, 54Reactome, 56SinoBiological, 50PharmGKB, 4Cell Signaling Technology, 53R&D Systems
See all sources

Pathways related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TP53, CDK4, CDKN2B
2
Hide members
9.5TP53, TSC1, MDM2
39.4TP53, CDK4, MDM2
49.4MDM2, CDKN2A, TP53
59.4MDM2, CDKN2A, TP53
69.4MDM2, CDKN2A, TP53
7
Hide members
9.4TP53, CDKN2A, MDM2
89.4TUBB, BRAF, EGFR
9
Hide members
9.3GFAP, SYNM, TUBB
10
Hide members
9.3MDM2, CDKN2A, CDKN2B, CDK4
119.3TP53, EGFR, MDM2
12
Hide members
9.2TP53, CDK4, CDKN2B, BRAF
13
Hide members
9.2MDM2, CDK4, TSC1, TP53
149.2CDKN2A, CDKN2B, CDK4, TP53
15
Hide members
9.2CDKN2A, CDKN2B, CDK4, TP53
169.1TP53, CDK4, MGMT
17
Transcription P53 signaling pathway
Hide members
9.1MDM2, CDKN2A, CDK4, TP53
18
Hide members
9.1MDM2, CDKN2A, CDK4, TP53
199.1TP53, GFAP, CDK4, EGFR
209.1TP53, CDKN2A, MDM2, BRAF
21
Hide members
9.0BRAF, MDM2, EGFR, TP53
22
Hide members
9.0BRAF, MDM2, EGFR, TP53
239.0TP53, EGFR, MDM2, BRAF
249.0MDM2, EGFR, CDKN2A, TP53
25
Hide members
8.9MGMT, MDM2, CDKN2A, CDK4
26
Hide members
8.9BRAF, MDM2, CDKN2B, TSC1, TP53
278.9TP53, CDK4, CDKN2B, CDKN2A, MDM2
288.8MDM2, EGFR, CDKN2B, CDK4, TP53
298.8MDM2, EGFR, CDK4, TSC1, TP53
308.8TP53, TSC1, CDK4, EGFR, MDM2
31
Hide members
8.6BRAF, MDM2, EGFR, CDKN2A, TP53
328.4BRAF, MDM2, EGFR, CDK4, TSC1, TP53
33
Hide members
8.4BRAF, MDM2, EGFR, CDKN2A, CDK4, TP53
348.1BRAF, MDM2, EGFR, CDKN2A, CDKN2B, CDK4
35
Hide members
7.6BRAF, MDM2, EGFR, CDKN2A, CDKN2B, CDK4
367.5TP53, BRAF, MGMT, MDM2, EGFR, CDKN2A

Compounds for genes affiliated with Pleomorphic Xanthoastrocytoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
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Compounds related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7GFAP
2vincristine45 50 1111.9TUBB, MGMT
3reticulin459.7GFAP, CD34, SYP
4depsipeptide459.6TP53, CDKN2A, TUBB
5dutp459.6SYP, GFAP, TP53, MDM2
6serine459.6TUBB, SYP, CDKN2B, TSC1, GFAP
7sodium bisulfite459.5CDKN2A, MGMT, CDKN2B
8roscovitine459.4CDK4, CDKN2A, TP53, MDM2
9hematoxylin459.4CDKN2A, GFAP, CD34, SYP
10acnu459.4CDKN2A, TP53, MGMT
117,12-dimethylbenz(a)anthracene459.4MDM2, CDKN2A, MGMT
12silver459.3GFAP, CD34, SYP, CDKN2A
13olomoucine45 1110.3CDKN2A, CDK4, TP53
145-methylcytosine45 2410.2TP53, CDKN2A, MGMT, CDKN2B
155-methylthioadenosine459.2CDKN2B, CDKN2A, EGFR
16cytarabine45 50 1111.2CDKN2B, TP53, CDKN2A, GFAP
17valine459.1BRAF, MDM2, TUBB, CDKN2A, CDK4
18crcs459.1BRAF, CDKN2A, TP53, MGMT
19chlorambucil45 1110.1TP53, MDM2, MGMT
20geldanamycin45 50 60 1112.1BRAF, CDK4, EGFR, MDM2, TP53
21flavopiridol45 1110.1CDK4, CDKN2A, EGFR, MDM2, TP53
22adpribose459.1EGFR, CDK4, TP53, MDM2
23temozolomide45 1110.0EGFR, TP53, MGMT, CDKN2A
24docetaxel45 50 60 1112.0TP53, CDKN2A, EGFR, MDM2, TUBB
25o6-methylguanine458.9MGMT, TP53, BRAF, CDKN2A, CDKN2B
26cyclic amp45 249.9BRAF, MDM2, GFAP, CDK4, CDKN2A, SYP
27pd 98,059458.8MDM2, TSC1, GFAP, CDK4, CDKN2B, EGFR
28camptothecin45 60 1110.8MDM2, CDKN2A, CDK4, MGMT, TP53
29bcnu458.8TP53, MGMT, CDKN2A, EGFR, GFAP
305-aza-2deoxycytidine458.8MDM2, CDKN2A, TP53, MGMT, CDKN2B
31carboplatin45 50 1110.8MGMT, MDM2, CDK4, TP53, EGFR
32curcumin458.7EGFR, MGMT, TP53, CDK4, MDM2
33testosterone45 60 11 2411.6TUBB, MDM2, EGFR, CDKN2A, CDK4, GFAP
34alanine458.6TSC1, CDKN2A, TUBB, BRAF, GFAP, CDK4
35threonine458.5GFAP, TSC1, BRAF, TUBB, MDM2, CDKN2A
36agar458.5BRAF, MDM2, GFAP, CD34, CDK4, CDKN2A
375fluorouracil458.5EGFR, CDK4, CDKN2A, MDM2, TP53, MGMT
38irinotecan45 50 1110.5MGMT, MDM2, EGFR, CDKN2A, TP53, BRAF
39genistein45 29 60 2 11 2413.5MGMT, GFAP, CDK4, CDKN2A, SYP, EGFR
40doxorubicin45 50 1110.4MGMT, TP53, CDK4, CDKN2A, EGFR, MDM2
41paclitaxel45 50 1110.2TUBB, GFAP, MDM2, TP53, CDK4, CDKN2A
42thymidylate458.1CDKN2A, EGFR, MDM2, CDK4, MGMT, TUBB
43oligonucleotide458.1MGMT, MDM2, TUBB, BRAF, CDK4, TP53
44thymidine45 249.0MGMT, MDM2, CDK4, CD34, GFAP, TUBB
45tyrosine457.7CD34, TUBB, GFAP, CDKN2B, CDK4, BRAF
46cisplatin45 50 60 1110.3GFAP, CDK4, CDKN2A, BRAF, EGFR, MGMT
47retinoic acid45 248.2TP53, GFAP, CDK4, BRAF, MGMT, EGFR
48progesterone45 60 29 11 2411.2CD34, BRAF, MGMT, MDM2, EGFR, SYP
49vegf456.9CD34, BRAF, TP53, TSC1, GFAP, CDK4
50paraffin455.7TP53, TUBB, CD68, BRAF, MGMT, MDM2

GO Terms for genes affiliated with Pleomorphic Xanthoastrocytoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.4MDM2, CDKN2A, TP53
2protein complexGO:0432349.0TP53, TSC1, CDKN2A, SYP, MDM2
3membraneGO:0160208.2TSC1, GFAP, CD68, SYNM, EGFR
4nucleoplasmGO:0056547.9MGMT, MDM2, CDKN2A, CDK4, SMARCB1, TP53
5cytosolGO:0058297.5TUBB, BRAF, MDM2, CDKN2A, CDKN2B, CDK4

Biological processes related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.8TP53, CDKN2A
2positive regulation of cell cycle arrestGO:0711589.7TP53, CDKN2A
3cell cycle arrestGO:0070509.4TP53, TSC1, CDKN2B, CDKN2A
4cellular response to organic substanceGO:0713109.3CD68, SYP
5positive regulation of gene expressionGO:0106289.3CD34, MDM2, BRAF
6negative regulation of cell proliferationGO:0082859.1CDKN2A, CDKN2B, TSC1, SMARCB1, TP53
7mitotic cell cycleGO:0002788.9TUBB, CDKN2A, CDKN2B, CDK4
8positive regulation of transcription from RNA polymerase II promoterGO:0459448.9EGFR, CDKN2A, CDKN2B, SMARCB1, TP53

Molecular functions related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.7TP53, CDKN2A
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.6CDKN2A, CDKN2B
3protein complex bindingGO:0324039.6CDK4, SYP, TUBB
4p53 bindingGO:0020399.2TP53, SMARCB1, CDKN2A, MDM2
5structural constituent of cytoskeletonGO:0052009.2GFAP, SYNM, TUBB
6identical protein bindingGO:0428028.8BRAF, MDM2, EGFR, SYP, TP53

Products for genes affiliated with Pleomorphic Xanthoastrocytoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pleomorphic Xanthoastrocytoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet