PXA
MCID: PLM020
MIFTS: 58

Pleomorphic Xanthoastrocytoma (PXA) malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Pleomorphic Xanthoastrocytoma

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Wikipedia:65 Pleomorphic Xanthoastrocytoma is a neoplasm of the brain that most frequently occurs in children and... more...

MalaCards based summary: Pleomorphic Xanthoastrocytoma, also known as pleomorphic xantho-astrocytoma, is related to dysembryoplastic neuroepithelial tumor and ganglioglioma. An important gene associated with Pleomorphic Xanthoastrocytoma is SYP (synaptophysin), and among its related pathways are Cytoplasmic microtubules and Cell cycle Regulation of G1 S transition part 1 . The compounds reticulin and dutp have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and parietal lobe, and related mouse phenotypes are pigmentation and respiratory system.

Aliases & Classifications for Pleomorphic Xanthoastrocytoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 62UMLS, 57SNOMED-CT, 39NCIt, 63UMLS via Orphanet
See all sources

Pleomorphic Xanthoastrocytoma, Aliases & Descriptions:

Name: Pleomorphic Xanthoastrocytoma 8 42 48 62
Pleomorphic Xantho-Astrocytoma 8 62
 
Pxa 42 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
pleomorphic xanthoastrocytoma:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:4852
NCIt39 C4323
SNOMED-CT57 78838008, 189924002
UMLS via Orphanet63 C0334586

Related Diseases for Pleomorphic Xanthoastrocytoma

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Diseases related to Pleomorphic Xanthoastrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1dysembryoplastic neuroepithelial tumor31.4SYP
2ganglioglioma31.2SYP, TSC1, TUBB, GFAP
3rhabdoid tumor31.1SMARCB1, SYP
4fibrous histiocytoma31.1CD34
5giant cell glioblastoma30.8GFAP, MDM2, EGFR
6tuberous sclerosis30.8SYP, TSC1, GFAP
7pilocytic astrocytoma30.4SYP, TSC1, GFAP, MGMT, CDK4
8meningioma30.1SMARCB1, GFAP, TSC1, SYP, CD68, CDKN2B
9glioblastoma29.2TUBB, MGMT, TP53, GFAP, SMARCB1, EGFR
10astrocytoma29.1CDKN2B, EGFR, CDK4, CDKN2A, MGMT, GFAP
11glioblastoma multiforme29.1MGMT, GFAP, TP53, TSC1, MDM2, CDKN2A
12oligodendroglioma28.8EGFR, CDKN2B, MGMT, GFAP, TP53, TSC1
13neurofibromatosis10.7
14gliomatosis cerebri10.6GFAP
15paraganglioma10.6SYP
16choroid plexus carcinoma10.6SMARCB1
17gemistocytic astrocytoma10.6GFAP
18cerebritis10.6
19spitz nevus10.5BRAF
20melanotic neuroectodermal tumor10.5SYP
21neuronitis10.5
22congenital mesoblastic nephroma10.5SMARCB1
23alexander disease10.5GFAP
24adult acute lymphocytic leukemia10.5CDKN2B
25pineocytoma10.5SYP, GFAP
26pineoblastoma10.5SYP, GFAP
27meningitis10.5
28papillary ependymoma10.4GFAP, SYP
29binswanger's disease10.4SYP, GFAP
30perineurioma10.4CD34
31central neurocytoma10.4SYP, GFAP
32choroid plexus papilloma10.4SYP, GFAP
33gliosarcoma10.4CDK4, GFAP
34subependymal giant cell astrocytoma10.4TSC1, SYP
35granular cell tumor10.4CD68, SYP
36anaplastic ependymoma10.4GFAP, MDM2
37oligoastrocytoma10.4GFAP, MGMT
38atypical teratoid rhabdoid tumor10.4
39arteriovenous malformation10.4
40cutaneous fibrous histiocytoma10.4CD68, CD34
41epithelioid sarcoma10.4CD34, SMARCB1
42hemangioblastoma10.3SYP, GFAP
43actinic keratosis10.3TP53
44neurilemmoma10.3CD34, SMARCB1, GFAP
45dedifferentiated liposarcoma10.3CDK4, MDM2
46myxoid liposarcoma10.3CDK4, MDM2
47chondrosarcoma10.3CDK4, MDM2
48fibroma10.3CD34, TSC1
49ganglioneuroma10.3GFAP, SYP
50acute myeloid leukemia, adult10.2CDKN2B, CD34

Graphical network of the top 20 diseases related to Pleomorphic Xanthoastrocytoma:



Diseases related to pleomorphic xanthoastrocytoma

Symptoms for Pleomorphic Xanthoastrocytoma

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Drugs & Therapeutics for Pleomorphic Xanthoastrocytoma

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Drug clinical trials:

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Genetic Tests for Pleomorphic Xanthoastrocytoma

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Anatomical Context for Pleomorphic Xanthoastrocytoma

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MalaCards organs/tissues related to Pleomorphic Xanthoastrocytoma:

32
Brain, Spinal cord, Parietal lobe, Temporal lobe, Cerebellum, Pineal, Retina, Testes, Medulla oblongata

Animal Models for Pleomorphic Xanthoastrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Xanthoastrocytoma:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.4TP53, EGFR, CDKN2A, MDM2, BRAF
2MP:00053888.3TP53, CDKN2A, TSC1, BRAF, EGFR
3MP:00053678.0TP53, BRAF, TSC1, MDM2, CDK4, EGFR
4MP:00053917.9EGFR, CDK4, CDKN2A, BRAF, TP53, GFAP
5MP:00028737.9EGFR, GFAP, TP53, BRAF, SYP, MDM2
6MP:00053867.9BRAF, TSC1, MDM2, CDKN2A, TP53, GFAP
7MP:00053707.7CDK4, CDKN2A, MDM2, TSC1, BRAF, TP53
8MP:00053817.7BRAF, TP53, GFAP, SMARCB1, MDM2, CDK4
9MP:00053857.7TSC1, EGFR, SMARCB1, GFAP, TP53, BRAF
10MP:00053697.6EGFR, CDK4, MDM2, TSC1, CDKN2A, GFAP
11MP:00053797.6TSC1, EGFR, CDKN2B, TP53, CDK4, BRAF
12MP:00053807.6SMARCB1, BRAF, EGFR, CDK4, CDKN2A, MDM2
13MP:00053897.4CDKN2A, MDM2, TSC1, BRAF, TP53, SMARCB1
14MP:00030127.2MGMT, EGFR, CDKN2B, TP53, CD68, CDKN2A
15MP:00053787.2CDK4, BRAF, TSC1, MDM2, CDKN2A, EGFR
16MP:00036317.1CDK4, TP53, BRAF, SMARCB1, GFAP, TSC1
17MP:00107717.1CDKN2A, EGFR, CD34, BRAF, TSC1, TP53
18MP:00053907.1EGFR, CD68, MDM2, TSC1, BRAF, TP53
19MP:00107686.7SMARCB1, BRAF, MDM2, CDKN2A, TSC1, TP53
20MP:00053846.7TP53, EGFR, CD34, CDKN2B, CDK4, MDM2
21MP:00053766.7TP53, GFAP, SMARCB1, MGMT, BRAF, TSC1
22MP:00020066.6CD34, CDKN2B, CDK4, CDKN2A, MDM2, TSC1
23MP:00053976.4BRAF, CD34, CDKN2B, CDK4, CD68, EGFR
24MP:00053876.1CDK4, EGFR, GFAP, SMARCB1, BRAF, TP53

Publications for Pleomorphic Xanthoastrocytoma

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Articles related to Pleomorphic Xanthoastrocytoma:

(show top 50)    (show all 205)
idTitleAuthorsYear
1
Successful Treatment of a Progressive BRAF V600E-Mutated Anaplastic Pleomorphic Xanthoastrocytoma With Vemurafenib Monotherapy. (25092772)
2014
2
Pleomorphic Xanthoastrocytoma: Natural History and Long-term Follow-up. (25318587)
2014
3
Pleomorphic Xanthoastrocytoma Within the Medulla Oblongata of a Young Dog. (24686391)
2014
4
Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression. (23442159)
2013
5
Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma. (24252190)
2013
6
Pleomorphic xanthoastrocytoma: magnetic resonance imaging findings in a series of cases with histopathological confirmation. (23249973)
2013
7
Atrial fibrillation as an uncommon presentation in a large pleomorphic xanthoastrocytoma. (22086138)
2012
8
Cerebral pleomorphic xanthoastrocytoma associated with NF1: an updated review with a rare atypical case from Africa. (22020543)
2012
9
Patterns of care and outcomes of patients with pleomorphic xanthoastrocytoma: a SEER analysis. (22843450)
2012
10
Pleomorphic xanthoastrocytoma - a clinico-pathological review. (22101999)
2011
11
Pleomorphic xanthoastrocytoma and oligodendroglioma: collision of 2 morphologically and genetically distinct anaplastic components. (21214337)
2011
12
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. (21274720)
2011
13
Temporal lobe pleomorphic xanthoastrocytoma and acquired BRAF mutation in an adolescent with the constitutional 22q11.2 deletion syndrome. (20730472)
2011
14
Primary spinal pleomorphic xanthoastrocytoma. (21045509)
2010
15
Pleomorphic xanthoastrocytoma presenting with life-threatening hemorrhage in a child. (19278318)
2009
16
Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma. (19099200)
2009
17
Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis--a pediatric case report and review of the literature. (19326050)
2009
18
Rapid progression of early delayed radiation effect in pleomorphic xanthoastrocytoma. (20062573)
2009
19
Pleomorphic xanthoastrocytoma in elderly patients may portend a poor prognosis. (18255294)
2008
20
Temporal pleomorphic xanthoastrocytoma with glycogen accumulation--case report. (18666439)
2008
21
Pleomorphic xanthoastrocytoma with an intracystic hemorrhage : a case report and literature review. (19096580)
2007
22
Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma. (17431546)
2007
23
Cerebellar pleomorphic xanthoastrocytoma: case report and literature review. (17537486)
2007
24
Unusual recurrence of pleomorphic xanthoastrocytoma. (17439101)
2006
25
Multicentric pleomorphic xanthoastrocytoma in a patient with neurofibromatosis type 1. Case report and review of the literature. (15739569)
2005
26
Pleomorphic xanthoastrocytoma with anaplastic features presenting without GFAP immunoreactivity: implications for differential diagnosis. (16193842)
2005
27
The use of chemotherapy to facilitate surgical resection in pleomorphic xanthoastrocytoma: experience in a single case. (11585332)
2001
28
Evaluation of pleomorphic xanthoastrocytoma by use of positron emission tomography with. (11156775)
2001
29
Pigmented pleomorphic xanthoastrocytoma: report of a rare case with review of the literature. (11371237)
2001
30
Combined oligodendroglioma/pleomorphic xanthoastrocytoma: a probable collision tumor: case report. (11383742)
2001
31
Cerebellar pleomorphic xanthoastrocytoma in an infant. (10504553)
1999
32
Pleomorphic xanthoastrocytoma with CT and MRI appearance of meningioma. (9987765)
1999
33
Pleomorphic xanthoastrocytoma: what do we really know about it? (10223246)
1999
34
Fatal pleomorphic xanthoastrocytoma with meningeal gliomatosis. (9602336)
1998
35
Late sequelae of treated pleomorphic xanthoastrocytoma: malignant brain stem astrocytoma occurring 15 years after radiation therapy. (9049863)
1997
36
Pleomorphic xanthoastrocytoma with gangliogliomatous component. (9521020)
1997
37
Clinical, radiological, and therapeutic features of pleomorphic xanthoastrocytoma: report of three patients and review of the literature. (8648341)
1996
38
Molecular genetic alterations in pleomorphic xanthoastrocytoma. (8834542)
1996
39
PET-FDG of pleomorphic xanthoastrocytoma. (7799091)
1995
40
Pleomorphic xanthoastrocytoma: report of two cases and brief review of the literature. (8477554)
1993
41
Pleomorphic xanthoastrocytoma associated with von Recklinghausen neurofibromatosis. (8481944)
1993
42
Pleomorphic xanthoastrocytoma: the birth of a diagnosis and a concept. (8293186)
1993
43
Telomeric associations evolving to ring chromosomes in a recurrent pleomorphic xanthoastrocytoma. (1606558)
1992
44
Pleomorphic xanthoastrocytoma: an immunohistochemical study of three cases. (1563714)
1992
45
Pleomorphic xanthoastrocytoma as a component of a cerebellar ganglioglioma: case report. (1513442)
1992
46
Temporal lobe tumor demonstrating ganglioglioma and pleomorphic xanthoastrocytoma components. Case report. (1607956)
1992
47
Pleomorphic xanthoastrocytoma. Ultrastructural, immunohistochemical, and DNA cytofluorometric study of a case. (1855184)
1991
48
Glioblastoma multiforme masquerading as a pleomorphic xanthoastrocytoma. (2547522)
1989
49
Pleomorphic xanthoastrocytoma. Immunohistochemical methods for differentiation from fibrous histiocytomas with similar morphology. (3010749)
1986
50
Pleomorphic xanthoastrocytoma: a report of two cases. (6687296)
1983

Variations for Pleomorphic Xanthoastrocytoma

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Expression for genes affiliated with Pleomorphic Xanthoastrocytoma

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Expression patterns in normal tissues for genes affiliated with Pleomorphic Xanthoastrocytoma

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Pathways for genes affiliated with Pleomorphic Xanthoastrocytoma

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Pathways related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.6SYNM, GFAP, TUBB
2
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.4CDKN2B, CDK4, CDKN2A
39.4CDK4, CDKN2B, TP53
4
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.3TSC1, MDM2, TP53
59.3CDK4, TP53, MGMT
69.3CDK4, MDM2, TP53
79.3CDK4, MDM2, TP53
8
Show member pathways
9.3MDM2, TP53, CDK4
9
Show member pathways
9.3CDK4, TP53, MDM2
10
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection37
9.1TUBB, EGFR, BRAF
11
Show member pathways
9.1TP53, MDM2, CDKN2A
129.1CDKN2A, MDM2, TP53
13
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.1CDKN2A, TP53, MDM2
149.1MDM2, TP53, CDKN2A
15
Show member pathways
9.1CDK4, CDKN2B, CDKN2A, MDM2
169.0BRAF, TP53, EGFR
17
Show member pathways
9.0TP53, EGFR, BRAF
18
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.0CDK4, MDM2, TSC1, TP53
199.0TP53, MDM2, EGFR
209.0EGFR, MDM2, TP53
21
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
8.9MDM2, EGFR, CDKN2B, BRAF
228.9CDKN2B, TP53, CDKN2A, CDK4
23
Show member pathways
8.9CDKN2A, CDK4, TP53, CDKN2B
248.8CDKN2A, MDM2, BRAF, TP53
258.8TP53, MDM2, CDKN2A, CDK4
26
Show member pathways
DNA damage response37
8.8CDK4, MDM2, TP53, CDKN2A
278.8TP53, EGFR, GFAP, CDK4
28
Show member pathways
8.7TP53, BRAF, MDM2, EGFR
298.7BRAF, EGFR, TP53, MDM2
30
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
8.7EGFR, MDM2, BRAF, TP53
31
Show member pathways
Signal transduction PTEN pathway60
8.7EGFR, TP53, BRAF, MDM2
328.5CDKN2A, CDK4, CDKN2B, TP53, MDM2
338.5CDK4, CDKN2B, CDKN2A, MDM2, TP53
34
Show member pathways
8.5TP53, CDK4, CDKN2A, MDM2, CDKN2B
35
Show member pathways
Cell cycle37
8.5CDKN2B, TP53, MDM2, CDK4, CDKN2A
368.5MDM2, CDKN2A, EGFR, TP53
37
Show member pathways
8.5MDM2, MGMT, CDKN2A, CDK4, TP53
388.4TP53, CDKN2B, CDK4, EGFR, MDM2
398.4TP53, TSC1, MDM2, CDK4, EGFR
408.4EGFR, CDK4, MDM2, TSC1, TP53
41
Show member pathways
8.2TP53, BRAF, MDM2, CDKN2A, EGFR
42
Show member pathways
8.1TP53, CDKN2A, MDM2, CDK4, CDKN2B, TUBB
438.1TP53, BRAF, TSC1, MDM2, CDK4, EGFR
44
Show member pathways
7.9EGFR, CDK4, CDKN2A, MDM2, BRAF, TP53
45
Show member pathways
7.9EGFR, MDM2, TSC1, BRAF, CDKN2B, GFAP
467.6CDKN2A, BRAF, MDM2, CDK4, CDKN2B, EGFR
47
Show member pathways
7.6EGFR, TP53, BRAF, MDM2, CDKN2B, CDK4
48
Show member pathways
Signaling Pathways in Glioblastoma37
7.3CDKN2A, MDM2, TSC1, BRAF, TP53, EGFR
497.3EGFR, CDK4, CDKN2A, MDM2, TSC1, BRAF
50
Show member pathways
7.1GFAP, BRAF, TSC1, MDM2, CDKN2A, CDK4

Compounds for genes affiliated with Pleomorphic Xanthoastrocytoma

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Compounds related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1reticulin449.5SYP, GFAP, CD34
2dutp449.4MDM2, TP53, GFAP, SYP
3acnu449.4MGMT, TP53, CDKN2A
4sodium bisulfite449.4CDKN2A, MGMT, CDKN2B
55-methylcytosine44 2410.3MGMT, TP53, CDKN2A, CDKN2B
6hematoxylin449.2CD34, CDKN2A, SYP, GFAP
7chlorambucil44 1110.2MGMT, TP53, MDM2
8crcs449.2CDKN2A, MGMT, TP53, BRAF
9silver449.2CDKN2A, CD34, SYP, GFAP
10depsipeptide449.1BRAF, CDKN2A, TP53, TUBB
11roscovitine449.1CDKN2A, TP53, CDK4, MDM2
12o6-methylguanine449.0CDKN2B, BRAF, TP53, MGMT, CDKN2A
137,12-dimethylbenz(a)anthracene449.0MGMT, CDKN2A, MDM2
14temozolomide44 119.9MGMT, EGFR, TP53, CDKN2A
15valine448.9CDKN2A, TUBB, BRAF, MDM2, CDK4
16camptothecin44 61 1110.8TP53, MDM2, CDKN2A, CDK4, MGMT
175-aza-2deoxycytidine448.8TP53, MGMT, MDM2, CDKN2A, CDKN2B
18cyclic amp44 249.8CDKN2A, GFAP, BRAF, SYP, CDK4, MDM2
19vincristine44 50 1110.7CDKN2A, TP53, TUBB, MGMT, MDM2
20geldanamycin44 50 61 1111.7BRAF, MDM2, CDK4, EGFR, TP53
21bcnu448.7CDKN2A, EGFR, MGMT, GFAP, TP53
22carboplatin44 50 1110.7MGMT, CDK4, TP53, MDM2, EGFR
23flavopiridol44 119.6EGFR, CDK4, CDKN2A, MDM2, TP53
24curcumin448.6CDK4, EGFR, MDM2, TP53, MGMT
25egcg448.6MGMT, TP53, CDK4, CDKN2A, EGFR
26adpribose448.5EGFR, CDK4, MDM2, TP53
27pd 98,059448.5MDM2, EGFR, CDKN2B, CDK4, GFAP, BRAF
28docetaxel44 50 61 1111.4TP53, MDM2, CDKN2A, EGFR, TUBB
29alanine448.3TUBB, CDK4, MDM2, TSC1, BRAF, CDKN2A
30genistein44 28 61 2 24 1113.3EGFR, MGMT, GFAP, SYP, MDM2, CDKN2A
31irinotecan44 50 1110.3EGFR, MGMT, TP53, BRAF, MDM2, CDKN2A
325fluorouracil448.2CDK4, EGFR, MDM2, TP53, MGMT, CDKN2A
33cysteine448.2MGMT, CDK4, CDKN2A, MDM2, SYP, GFAP
34threonine448.2TUBB, TSC1, BRAF, MDM2, CDK4, GFAP
35testosterone44 61 24 1111.2SYP, MDM2, CDKN2A, CDK4, EGFR, GFAP
36doxorubicin44 50 1110.2EGFR, CDK4, MGMT, TP53, CDKN2A, MDM2
37thymidine44 249.1MDM2, TP53, GFAP, CD34, MGMT, TUBB
38cycloheximide448.1CDKN2A, CDK4, EGFR, MDM2, TP53, GFAP
39oligonucleotide448.1BRAF, TP53, MDM2, CDK4, CDKN2A, MGMT
40agar448.0GFAP, BRAF, MDM2, CDK4, CD34, EGFR
41thymidylate447.9EGFR, CDK4, CDKN2A, MDM2, MGMT, TUBB
42paclitaxel44 50 119.3MGMT, BRAF, EGFR, CDK4, CDKN2A, MDM2
43tyrosine447.3BRAF, TSC1, GFAP, TUBB, EGFR, CD34
44cisplatin44 50 61 1110.1MDM2, TP53, BRAF, SYP, CDK4, EGFR
45retinoic acid44 248.1SYP, CDK4, TP53, MGMT, GFAP, BRAF
46progesterone44 28 61 24 1111.0EGFR, CD34, CDK4, CDKN2A, TP53, MGMT
47serine446.9CDKN2A, GFAP, TP53, TUBB, EGFR, CDKN2B
48vegf446.7GFAP, MGMT, TP53, BRAF, TSC1, SYP
49estrogen446.3EGFR, CD34, CDKN2B, CDK4, CDKN2A, MDM2
50paraffin445.5CD34, TP53, BRAF, TUBB, MGMT, TSC1

GO Terms for genes affiliated with Pleomorphic Xanthoastrocytoma

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Cellular components related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.2TP53, MDM2, CDKN2A
2protein complexGO:0432348.8CDKN2A, MDM2, SYP, TSC1, TP53
3nucleoplasmGO:0056548.3MGMT, SMARCB1, TP53, MDM2, CDKN2A, CDK4
4membraneGO:0160208.3GFAP, TSC1, SYNM, CD68, EGFR
5nucleolusGO:0057308.0SMARCB1, TP53, MDM2, CDKN2A, CDK4, CDKN2B
6cytosolGO:0058297.4TUBB, GFAP, TP53, BRAF, TSC1, MDM2
7cytoplasmGO:0057377.2TP53, TSC1, MDM2, CDKN2A, CDKN2B, CD34
8nucleusGO:0056346.9MGMT, SMARCB1, TP53, BRAF, MDM2, CDKN2A

Biological processes related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:07115710.0CDK4, MDM2
2negative regulation of phosphorylationGO:0423269.8CDKN2B, CDKN2A
3replicative senescenceGO:0903999.8CDKN2A, TP53
4protein destabilizationGO:0316489.7MDM2, CDKN2A
5positive regulation of cell cycle arrestGO:0711589.6TP53, CDKN2A
6cellular response to organic substanceGO:0713109.6SYP, CD68
7cellular response to ionizing radiationGO:0714799.6TP53, MGMT
8positive regulation of gene expressionGO:0106289.5CD34, MDM2, BRAF
9mitotic cell cycleGO:0002789.3TUBB, CDKN2A, CDK4, CDKN2B
10cell cycle arrestGO:0070509.2CDKN2B, CDKN2A, TSC1, TP53
11positive regulation of DNA repairGO:0457399.2EGFR, MGMT
12fibroblast growth factor receptor signaling pathwayGO:0085439.1BRAF, MDM2, EGFR
13negative regulation of cell proliferationGO:0082859.0SMARCB1, TP53, TSC1, CDKN2A, CDKN2B
14negative regulation of apoptotic processGO:0430668.8EGFR, MDM2, BRAF, TP53
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.6SMARCB1, TP53, CDKN2A, CDKN2B, EGFR

Molecular functions related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.8CDKN2B, CDKN2A
2GTPase activating protein bindingGO:0327949.7TSC1, TUBB
3structural constituent of cytoskeletonGO:0052009.6TUBB, GFAP, SYNM
4MDM2/MDM4 family protein bindingGO:0973719.6TP53, CDKN2A
5protein complex bindingGO:0324039.5CDK4, SYP, TUBB
6MAP kinase kinase kinase activityGO:0047099.3BRAF, EGFR
7p53 bindingGO:0020399.1CDKN2A, MDM2, TP53, SMARCB1
8protein kinase bindingGO:0199018.7EGFR, CDKN2B, CDKN2A, TP53
9identical protein bindingGO:0428028.6TP53, BRAF, SYP, MDM2, EGFR
10protein bindingGO:0055156.6TUBB, SMARCB1, TP53, BRAF, TSC1, SYNM

Products for genes affiliated with Pleomorphic Xanthoastrocytoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Pleomorphic Xanthoastrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet