PXA
MCID: PLM020
MIFTS: 57

Pleomorphic Xanthoastrocytoma (PXA) malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Pleomorphic Xanthoastrocytoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Pleomorphic Xanthoastrocytoma is a neoplasm of the brain that occurs often in children and teenagers.... more...

MalaCards: Pleomorphic Xanthoastrocytoma, also known as PXA, is related to ganglioglioma and giant cell glioblastoma. An important gene associated with Pleomorphic Xanthoastrocytoma is SYP (synaptophysin), and among its related pathways are Cytoplasmic microtubules and Cell cycle Regulation of G1 S transition part 1 . The compounds reticulin and dutp have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and parietal lobe, and related mouse phenotypes are pigmentation and respiratory system.

Aliases & Classifications for Pleomorphic Xanthoastrocytoma

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8Disease Ontology, 43NIH Rare Diseases, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
pleomorphic xanthoastrocytoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pleomorphic xanthoastrocytoma 8 43 49 62
pxa 43 49
pleomorphic xantho-astrocytoma 8


External Ids:

Disease Ontology8 DOID:4852
NCIt40 C4323
SNOMED-CT58 189924002, 78838008
SNOMED-CT via Orphanet59 78838008
UMLS via Orphanet63 C0334586

Related Diseases for Pleomorphic Xanthoastrocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Pleomorphic Xanthoastrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1ganglioglioma31.0SYP, TSC1, GFAP, TUBB
2giant cell glioblastoma30.6GFAP, MDM2, EGFR
3dysembryoplastic neuroepithelial tumor30.5SYP
4fibrous histiocytoma30.5CD34
5rhabdoid tumor30.4SYP, SMARCB1
6astrocytoma30.4SYP, MDM2, CDKN2A, CDK4, CDKN2B, EGFR
7oligodendroglioma30.4MGMT, GFAP, BRAF, CDKN2A, CDKN2B, EGFR
8pilocytic astrocytoma30.3CDK4, SYP, TSC1, GFAP, MGMT
9meningioma30.3CD34, CDKN2B, SMARCB1, GFAP, TSC1, SYP
10glioblastoma multiforme30.2MGMT, TUBB, SMARCB1, GFAP, TP53, MDM2
11anaplastic astrocytoma30.0MGMT, GFAP, TP53, MDM2, CDKN2A, CDK4
12neurofibromatosis10.7
13cerebritis10.6
14neuronitis10.5
15meningitis10.4
16arteriovenous malformation10.4
17atypical teratoid rhabdoid tumor10.2
18moyamoya disease10.2
19histiocytoma10.2
20desmoplastic infantile ganglioglioma10.2
21sturge-weber syndrome10.2
22weber syndrome10.2
23gliomatosis cerebri10.1GFAP
24choroid plexus carcinoma10.1SMARCB1
25glomus tumor10.1SYP
26gemistocytic astrocytoma10.1GFAP
27spitz nevus10.1BRAF
28melanotic neuroectodermal tumor10.1SYP
29congenital mesoblastic nephroma10.1SMARCB1
30alexander disease10.1GFAP
31adult acute lymphocytic leukemia10.1CDKN2B
32pineocytoma10.1SYP, GFAP
33pineoblastoma10.1SYP, GFAP
34papillary ependymoma10.1SYP, GFAP
35binswanger's disease10.1SYP, GFAP
36perineurioma10.1CD34
37central neurocytoma10.1GFAP, SYP
38choroid plexus papilloma10.1SYP, GFAP
39gliosarcoma10.1GFAP, CDK4
40subependymal giant cell astrocytoma10.1TSC1, SYP
41granular cell tumor10.1CD68, SYP
42oligoastrocytoma10.1MGMT, GFAP
43anaplastic ependymoma10.1MDM2, GFAP
44cutaneous fibrous histiocytoma10.1CD68, CD34
45epithelioid sarcoma10.1SMARCB1, CD34
46actinic keratosis10.1TP53
47tuberous sclerosis10.1GFAP, TSC1, SYP
48hemangioblastoma10.1GFAP, SYP
49neurilemmoma10.1CD34, GFAP, SMARCB1
50dedifferentiated liposarcoma10.1MDM2, CDK4

Graphical network of the top 20 diseases related to Pleomorphic Xanthoastrocytoma:



Diseases related to pleomorphic xanthoastrocytoma

Symptoms for Pleomorphic Xanthoastrocytoma

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Drugs & Therapeutics for Pleomorphic Xanthoastrocytoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pleomorphic Xanthoastrocytoma

Search NIH Clinical Center for Pleomorphic Xanthoastrocytoma

Genetic Tests for Pleomorphic Xanthoastrocytoma

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Anatomical Context for Pleomorphic Xanthoastrocytoma

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33MalaCards
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MalaCards organs/tissues related to Pleomorphic Xanthoastrocytoma:

33
Brain, Spinal cord, Parietal lobe, Temporal lobe, Cerebellum, Pineal, Retina, Testes

Animal Models for Pleomorphic Xanthoastrocytoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pleomorphic Xanthoastrocytoma:

37 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.4TP53, BRAF, MDM2, CDKN2A, EGFR
2MP:00053888.3EGFR, CDKN2A, TSC1, BRAF, TP53
3MP:00053678.0TP53, BRAF, TSC1, MDM2, CDK4, CDKN2B
4MP:00053917.9SMARCB1, GFAP, TP53, BRAF, CDKN2A, CDK4
5MP:00028737.9GFAP, TP53, BRAF, SYP, MDM2, EGFR
6MP:00053867.9GFAP, TP53, BRAF, TSC1, MDM2, CDKN2A
7MP:00053707.7SMARCB1, TP53, BRAF, TSC1, MDM2, CDKN2A
8MP:00053817.7CDK4, CDKN2A, MDM2, BRAF, TP53, GFAP
9MP:00053857.7SMARCB1, GFAP, TP53, BRAF, TSC1, MDM2
10MP:00053697.6GFAP, TP53, BRAF, TSC1, MDM2, CDKN2A
11MP:00053797.6MGMT, TP53, BRAF, TSC1, CDKN2A, CDK4
12MP:00053807.6SMARCB1, TP53, BRAF, TSC1, MDM2, CDKN2A
13MP:00053897.4SMARCB1, TP53, EGFR, CDKN2B, CDK4, CDKN2A
14MP:00030127.2MGMT, TP53, SYP, MDM2, CDKN2A, CD68
15MP:00053787.2SMARCB1, GFAP, TP53, BRAF, TSC1, MDM2
16MP:00036317.1SMARCB1, GFAP, TP53, BRAF, TSC1, SYP
17MP:00107717.1TP53, BRAF, TSC1, MDM2, CDKN2A, CDK4
18MP:00053907.1TP53, BRAF, TSC1, MDM2, CDKN2A, CD68
19MP:00107686.7TP53, GFAP, SMARCB1, MGMT, BRAF, TSC1
20MP:00053846.7BRAF, TP53, GFAP, SMARCB1, TSC1, MDM2
21MP:00053766.7MGMT, SMARCB1, GFAP, TP53, BRAF, TSC1
22MP:00020066.6EGFR, MGMT, SMARCB1, TP53, BRAF, TSC1
23MP:00053976.4SMARCB1, TP53, BRAF, MDM2, CDKN2A, CD68
24MP:00053876.1BRAF, TP53, GFAP, SMARCB1, MDM2, CDKN2A

Publications for Pleomorphic Xanthoastrocytoma

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52PubMed
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Articles related to Pleomorphic Xanthoastrocytoma:

(show top 50)    (show all 189)
idTitleAuthorsYear
1
Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma. (24252190)
2013
2
Pleomorphic xanthoastrocytoma: magnetic resonance imaging findings in a series of cases with histopathological confirmation. (23249973)
2013
3
Atrial fibrillation as an uncommon presentation in a large pleomorphic xanthoastrocytoma. (22086138)
2012
4
Cerebral pleomorphic xanthoastrocytoma associated with NF1: an updated review with a rare atypical case from Africa. (22020543)
2012
5
Patterns of care and outcomes of patients with pleomorphic xanthoastrocytoma: a SEER analysis. (22843450)
2012
6
Pleomorphic xanthoastrocytoma - a clinico-pathological review. (22101999)
2011
7
Pleomorphic xanthoastrocytoma and oligodendroglioma: collision of 2 morphologically and genetically distinct anaplastic components. (21214337)
2011
8
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. (21274720)
2011
9
Temporal lobe pleomorphic xanthoastrocytoma and acquired BRAF mutation in an adolescent with the constitutional 22q11.2 deletion syndrome. (20730472)
2011
10
Primary spinal pleomorphic xanthoastrocytoma. (21045509)
2010
11
Pleomorphic xanthoastrocytoma presenting with life-threatening hemorrhage in a child. (19278318)
2009
12
Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma. (19099200)
2009
13
Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis--a pediatric case report and review of the literature. (19326050)
2009
14
Rapid progression of early delayed radiation effect in pleomorphic xanthoastrocytoma. (20062573)
2009
15
Pleomorphic xanthoastrocytoma in elderly patients may portend a poor prognosis. (18255294)
2008
16
Temporal pleomorphic xanthoastrocytoma with glycogen accumulation--case report. (18666439)
2008
17
Pleomorphic xanthoastrocytoma with an intracystic hemorrhage : a case report and literature review. (19096580)
2007
18
Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma. (17431546)
2007
19
Cerebellar pleomorphic xanthoastrocytoma: case report and literature review. (17537486)
2007
20
Unusual recurrence of pleomorphic xanthoastrocytoma. (17439101)
2006
21
Multicentric pleomorphic xanthoastrocytoma in a patient with neurofibromatosis type 1. Case report and review of the literature. (15739569)
2005
22
Pleomorphic xanthoastrocytoma with anaplastic features presenting without GFAP immunoreactivity: implications for differential diagnosis. (16193842)
2005
23
Cerebral anaplastic pleomorphic xanthoastrocytoma with meningeal dissemination at first presentation. (14669022)
2004
24
Unique presentation of pleomorphic xanthoastrocytoma as a lytic skull lesion in an eight-year-old girl. (12411717)
2002
25
The use of chemotherapy to facilitate surgical resection in pleomorphic xanthoastrocytoma: experience in a single case. (11585332)
2001
26
Evaluation of pleomorphic xanthoastrocytoma by use of positron emission tomography with. (11156775)
2001
27
Pigmented pleomorphic xanthoastrocytoma: report of a rare case with review of the literature. (11371237)
2001
28
Combined oligodendroglioma/pleomorphic xanthoastrocytoma: a probable collision tumor: case report. (11383742)
2001
29
Cerebellar pleomorphic xanthoastrocytoma in an infant. (10504553)
1999
30
Pleomorphic xanthoastrocytoma with CT and MRI appearance of meningioma. (9987765)
1999
31
Pleomorphic xanthoastrocytoma: what do we really know about it? (10223246)
1999
32
Fatal pleomorphic xanthoastrocytoma with meningeal gliomatosis. (9602336)
1998
33
Atypical pleomorphic xanthoastrocytoma. (10192056)
1998
34
Late sequelae of treated pleomorphic xanthoastrocytoma: malignant brain stem astrocytoma occurring 15 years after radiation therapy. (9049863)
1997
35
Pleomorphic xanthoastrocytoma with gangliogliomatous component. (9521020)
1997
36
Clinical, radiological, and therapeutic features of pleomorphic xanthoastrocytoma: report of three patients and review of the literature. (8648341)
1996
37
Molecular genetic alterations in pleomorphic xanthoastrocytoma. (8834542)
1996
38
PET-FDG of pleomorphic xanthoastrocytoma. (7799091)
1995
39
Pleomorphic xanthoastrocytoma: report of two cases and brief review of the literature. (8477554)
1993
40
Pleomorphic xanthoastrocytoma associated with von Recklinghausen neurofibromatosis. (8481944)
1993
41
Pleomorphic xanthoastrocytoma: the birth of a diagnosis and a concept. (8293186)
1993
42
Pleomorphic xanthoastrocytoma, a distinctive astroglial tumor: neuroradiologic and pathologic features. (8279337)
1993
43
Telomeric associations evolving to ring chromosomes in a recurrent pleomorphic xanthoastrocytoma. (1606558)
1992
44
Pleomorphic xanthoastrocytoma: an immunohistochemical study of three cases. (1563714)
1992
45
Pleomorphic xanthoastrocytoma as a component of a cerebellar ganglioglioma: case report. (1513442)
1992
46
Temporal lobe tumor demonstrating ganglioglioma and pleomorphic xanthoastrocytoma components. Case report. (1607956)
1992
47
Pleomorphic xanthoastrocytoma. Ultrastructural, immunohistochemical, and DNA cytofluorometric study of a case. (1855184)
1991
48
Glioblastoma multiforme masquerading as a pleomorphic xanthoastrocytoma. (2547522)
1989
49
Pleomorphic xanthoastrocytoma. Immunohistochemical methods for differentiation from fibrous histiocytomas with similar morphology. (3010749)
1986
50
Pleomorphic xanthoastrocytoma: a report of two cases. (6687296)
1983

Variations for Pleomorphic Xanthoastrocytoma

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Expression for genes affiliated with Pleomorphic Xanthoastrocytoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleomorphic Xanthoastrocytoma

Search GEO for disease gene expression data for Pleomorphic Xanthoastrocytoma.

Pathways for genes affiliated with Pleomorphic Xanthoastrocytoma

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Sources:
50PathCards, 12EMD Millipore, 60Thomson Reuters, 30KEGG, 53QIAGEN, 57SinoBiological, 38NCBI BioSystems Database, 55Reactome, 61Tocris Bioscience, 51PharmGKB, 5Cell Signaling Technology, 54R&D Systems
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Pathways related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.6SYNM, GFAP, TUBB
2
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.4CDKN2A, CDK4, CDKN2B
39.4TP53, CDK4, CDKN2B
4
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.3MDM2, TSC1, TP53
59.3MGMT, TP53, CDK4
6
Show member pathways
9.3TP53, MDM2, CDK4
7
Show member pathways
9.3TP53, MDM2, CDK4
89.3CDK4, MDM2, TP53
99.3CDK4, MDM2, TP53
10
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection38
9.1TUBB, BRAF, EGFR
119.1CDKN2A, MDM2, TP53
12
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.1CDKN2A, MDM2, TP53
139.1TP53, MDM2, CDKN2A
14
Show member pathways
9.1TP53, MDM2, CDKN2A
15
Show member pathways
9.1MDM2, CDKN2A, CDK4, CDKN2B
169.0EGFR, BRAF, TP53
17
Show member pathways
9.0TP53, BRAF, EGFR
18
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.0CDK4, MDM2, TSC1, TP53
199.0TP53, MDM2, EGFR
209.0EGFR, MDM2, TP53
21
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
8.9EGFR, CDKN2B, MDM2, BRAF
228.9TP53, CDKN2A, CDK4, CDKN2B
23
Show member pathways
8.9CDKN2B, CDK4, CDKN2A, TP53
248.8TP53, BRAF, MDM2, CDKN2A
25
Show member pathways
DNA damage response38
8.8TP53, MDM2, CDKN2A, CDK4
268.8CDK4, CDKN2A, MDM2, TP53
278.8EGFR, CDK4, TP53, GFAP
288.7TP53, BRAF, MDM2, EGFR
29
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
8.7TP53, BRAF, MDM2, EGFR
30
Show member pathways
Signal transduction PTEN pathway60
8.7TP53, BRAF, MDM2, EGFR
31
Show member pathways
8.7EGFR, MDM2, BRAF, TP53
32
Show member pathways
8.5TP53, MDM2, CDKN2A, CDK4, CDKN2B
33
Show member pathways
Cell cycle38
8.5TP53, MDM2, CDKN2A, CDK4, CDKN2B
348.5TP53, MDM2, CDKN2A, CDK4, CDKN2B
358.5TP53, MDM2, CDKN2A, CDK4, CDKN2B
368.5EGFR, CDKN2A, MDM2, TP53
37
Show member pathways
8.5MGMT, TP53, MDM2, CDKN2A, CDK4
388.4TP53, MDM2, CDK4, CDKN2B, EGFR
398.4TP53, TSC1, MDM2, CDK4, EGFR
408.4TP53, TSC1, MDM2, CDK4, EGFR
41
Show member pathways
8.2EGFR, CDKN2A, MDM2, BRAF, TP53
42
Show member pathways
8.1TUBB, TP53, MDM2, CDKN2A, CDK4, CDKN2B
438.1TP53, BRAF, TSC1, MDM2, CDK4, EGFR
44
Show member pathways
7.9TP53, BRAF, MDM2, CDKN2A, CDK4, EGFR
45
Show member pathways
7.9GFAP, TP53, BRAF, TSC1, MDM2, CDKN2B
46
Show member pathways
7.6TP53, BRAF, MDM2, CDKN2A, CDK4, CDKN2B
477.6TP53, BRAF, MDM2, CDKN2A, CDK4, CDKN2B
48
Show member pathways
Signaling Pathways in Glioblastoma38
7.3TP53, BRAF, TSC1, MDM2, CDKN2A, CDK4
497.3EGFR, MGMT, TP53, BRAF, TSC1, MDM2
50
Show member pathways
7.1GFAP, TP53, BRAF, TSC1, MDM2, CDKN2A

Compounds for genes affiliated with Pleomorphic Xanthoastrocytoma

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45Novoseek, 24HMDB, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 29IUPHAR, 3BitterDB
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Compounds related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1reticulin459.5SYP, GFAP, CD34
2dutp459.4MDM2, TP53, GFAP, SYP
3acnu459.4MGMT, TP53, CDKN2A
4sodium bisulfite459.4CDKN2A, MGMT, CDKN2B
55-methylcytosine45 2410.3MGMT, TP53, CDKN2A, CDKN2B
6hematoxylin459.2CD34, CDKN2A, SYP, GFAP
7chlorambucil45 1110.2MGMT, TP53, MDM2
8crcs459.2CDKN2A, MGMT, TP53, BRAF
9silver459.2CDKN2A, CD34, SYP, GFAP
10depsipeptide459.1BRAF, CDKN2A, TP53, TUBB
11roscovitine459.1CDKN2A, TP53, CDK4, MDM2
12o6-methylguanine459.0CDKN2B, BRAF, TP53, MGMT, CDKN2A
137,12-dimethylbenz(a)anthracene459.0MGMT, CDKN2A, MDM2
14temozolomide45 119.9MGMT, EGFR, TP53, CDKN2A
15valine458.9CDKN2A, TUBB, BRAF, MDM2, CDK4
16camptothecin45 61 1110.8TP53, MDM2, CDKN2A, CDK4, MGMT
175-aza-2deoxycytidine458.8TP53, MGMT, MDM2, CDKN2A, CDKN2B
18cyclic amp45 249.8CDKN2A, GFAP, BRAF, SYP, CDK4, MDM2
19vincristine45 51 1110.7CDKN2A, TP53, TUBB, MGMT, MDM2
20geldanamycin45 51 61 1111.7BRAF, MDM2, CDK4, EGFR, TP53
21bcnu458.7CDKN2A, EGFR, MGMT, GFAP, TP53
22carboplatin45 51 1110.7MGMT, CDK4, TP53, MDM2, EGFR
23flavopiridol45 119.6EGFR, CDK4, CDKN2A, MDM2, TP53
24curcumin458.6CDK4, EGFR, MDM2, TP53, MGMT
25egcg458.6MGMT, TP53, CDK4, CDKN2A, EGFR
26adpribose458.5EGFR, CDK4, MDM2, TP53
27pd 98,059458.5MDM2, EGFR, CDKN2B, CDK4, GFAP, BRAF
28docetaxel45 51 61 1111.4TP53, MDM2, CDKN2A, EGFR, TUBB
29alanine458.3TUBB, CDK4, MDM2, TSC1, BRAF, CDKN2A
30genistein45 29 61 3 24 1113.3EGFR, MGMT, GFAP, SYP, MDM2, CDKN2A
31irinotecan45 51 1110.3EGFR, MGMT, TP53, BRAF, MDM2, CDKN2A
325fluorouracil458.2CDK4, EGFR, MDM2, TP53, MGMT, CDKN2A
33cysteine458.2MGMT, CDK4, CDKN2A, MDM2, SYP, GFAP
34threonine458.2TUBB, TSC1, BRAF, MDM2, CDK4, GFAP
35testosterone45 61 24 1111.2SYP, MDM2, CDKN2A, CDK4, EGFR, GFAP
36doxorubicin45 51 1110.2EGFR, CDK4, MGMT, TP53, CDKN2A, MDM2
37thymidine45 249.1MDM2, TP53, GFAP, CD34, MGMT, TUBB
38cycloheximide458.1CDKN2A, CDK4, EGFR, MDM2, TP53, GFAP
39oligonucleotide458.1BRAF, TP53, MDM2, CDK4, CDKN2A, MGMT
40agar458.0GFAP, BRAF, MDM2, CDK4, CD34, EGFR
41thymidylate457.9EGFR, CDK4, CDKN2A, MDM2, MGMT, TUBB
42paclitaxel45 51 119.3MGMT, BRAF, EGFR, CDK4, CDKN2A, MDM2
43tyrosine457.3BRAF, TSC1, GFAP, TUBB, EGFR, CD34
44cisplatin45 51 61 1110.1MDM2, TP53, BRAF, SYP, CDK4, EGFR
45retinoic acid45 248.1SYP, CDK4, TP53, MGMT, GFAP, BRAF
46progesterone45 29 61 24 1111.0EGFR, CD34, CDK4, CDKN2A, TP53, MGMT
47serine456.9CDKN2A, GFAP, TP53, TUBB, EGFR, CDKN2B
48vegf456.7GFAP, MGMT, TP53, BRAF, TSC1, SYP
49estrogen456.3EGFR, CD34, CDKN2B, CDK4, CDKN2A, MDM2
50paraffin455.5CD34, TP53, BRAF, TUBB, MGMT, TSC1

GO Terms for genes affiliated with Pleomorphic Xanthoastrocytoma

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16Gene Ontology
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Cellular components related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.2TP53, MDM2, CDKN2A
2protein complexGO:0432348.8CDKN2A, MDM2, SYP, TSC1, TP53
3nucleoplasmGO:0056548.3MGMT, SMARCB1, TP53, MDM2, CDKN2A, CDK4
4membraneGO:0160208.3GFAP, TSC1, SYNM, CD68, EGFR
5nucleolusGO:0057308.0SMARCB1, TP53, MDM2, CDKN2A, CDK4, CDKN2B
6cytosolGO:0058297.4TUBB, GFAP, TP53, BRAF, TSC1, MDM2
7cytoplasmGO:0057377.2TP53, TSC1, MDM2, CDKN2A, CDKN2B, CD34
8nucleusGO:0056346.9MGMT, SMARCB1, TP53, BRAF, MDM2, CDKN2A

Biological processes related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:07115710.0CDK4, MDM2
2negative regulation of phosphorylationGO:0423269.8CDKN2B, CDKN2A
3replicative senescenceGO:0903999.8CDKN2A, TP53
4protein destabilizationGO:0316489.7MDM2, CDKN2A
5positive regulation of cell cycle arrestGO:0711589.6TP53, CDKN2A
6cellular response to organic substanceGO:0713109.6SYP, CD68
7cellular response to ionizing radiationGO:0714799.6TP53, MGMT
8positive regulation of gene expressionGO:0106289.5CD34, MDM2, BRAF
9mitotic cell cycleGO:0002789.3TUBB, CDKN2A, CDK4, CDKN2B
10cell cycle arrestGO:0070509.2CDKN2B, CDKN2A, TSC1, TP53
11positive regulation of DNA repairGO:0457399.2EGFR, MGMT
12fibroblast growth factor receptor signaling pathwayGO:0085439.1BRAF, MDM2, EGFR
13negative regulation of cell proliferationGO:0082859.0SMARCB1, TP53, TSC1, CDKN2A, CDKN2B
14negative regulation of apoptotic processGO:0430668.8EGFR, MDM2, BRAF, TP53
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.6SMARCB1, TP53, CDKN2A, CDKN2B, EGFR

Molecular functions related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.8CDKN2B, CDKN2A
2GTPase activating protein bindingGO:0327949.7TSC1, TUBB
3structural constituent of cytoskeletonGO:0052009.6TUBB, GFAP, SYNM
4MDM2/MDM4 family protein bindingGO:0973719.6TP53, CDKN2A
5protein complex bindingGO:0324039.5CDK4, SYP, TUBB
6MAP kinase kinase kinase activityGO:0047099.3BRAF, EGFR
7p53 bindingGO:0020399.1CDKN2A, MDM2, TP53, SMARCB1
8protein kinase bindingGO:0199018.7EGFR, CDKN2B, CDKN2A, TP53
9identical protein bindingGO:0428028.6TP53, BRAF, SYP, MDM2, EGFR
10protein bindingGO:0055156.6TUBB, SMARCB1, TP53, BRAF, TSC1, SYNM

Products for genes affiliated with Pleomorphic Xanthoastrocytoma

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Sources for Pleomorphic Xanthoastrocytoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet