PXA
MCID: PLM020
MIFTS: 57

Pleomorphic Xanthoastrocytoma (PXA) malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Pleomorphic Xanthoastrocytoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Pleomorphic Xanthoastrocytoma is a neoplasm of the brain that occurs often in children and teenagers.... more...

MalaCards: Pleomorphic Xanthoastrocytoma, also known as PXA, is related to ganglioglioma and giant cell glioblastoma. An important gene associated with Pleomorphic Xanthoastrocytoma is SYP (synaptophysin), and among its related pathways are Cytoplasmic microtubules and Cell cycle Regulation of G1 S transition part 1 . The compounds reticulin and dutp have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and parietal lobe, and related mouse phenotypes are pigmentation and respiratory system.

Aliases & Classifications for Pleomorphic Xanthoastrocytoma

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9Disease Ontology, 44NIH Rare Diseases, 50Orphanet, 63UMLS, 59SNOMED-CT, 41NCIt, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
pleomorphic xanthoastrocytoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pleomorphic xanthoastrocytoma 9 44 50 63
pxa 44 50
pleomorphic xantho-astrocytoma 9


External Ids:

Disease Ontology9 DOID:4852
NCIt41 C4323
SNOMED-CT59 189924002, 78838008
SNOMED-CT via Orphanet60 78838008
UMLS via Orphanet64 C0334586

Related Diseases for Pleomorphic Xanthoastrocytoma

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18GeneCards, 19GeneDecks
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Diseases related to Pleomorphic Xanthoastrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1ganglioglioma31.0SYP, TSC1, GFAP, TUBB
2giant cell glioblastoma30.6GFAP, MDM2, EGFR
3dysembryoplastic neuroepithelial tumor30.5SYP
4fibrous histiocytoma30.5CD34
5rhabdoid tumor30.4SYP, SMARCB1
6astrocytoma30.4SYP, MDM2, CDKN2A, CDK4, CDKN2B, EGFR
7oligodendroglioma30.4MGMT, GFAP, BRAF, CDKN2A, CDKN2B, EGFR
8pilocytic astrocytoma30.3CDK4, SYP, TSC1, GFAP, MGMT
9meningioma30.3CD34, CDKN2B, SMARCB1, GFAP, TSC1, SYP
10glioblastoma multiforme30.2MGMT, TUBB, SMARCB1, GFAP, TP53, MDM2
11anaplastic astrocytoma30.0MGMT, GFAP, TP53, MDM2, CDKN2A, CDK4
12neurofibromatosis10.7
13cerebritis10.6
14neuronitis10.5
15meningitis10.4
16arteriovenous malformation10.4
17atypical teratoid rhabdoid tumor10.2
18moyamoya disease10.2
19histiocytoma10.2
20desmoplastic infantile ganglioglioma10.2
21sturge-weber syndrome10.2
22weber syndrome10.2
23gliomatosis cerebri10.1GFAP
24choroid plexus carcinoma10.1SMARCB1
25glomus tumor10.1SYP
26gemistocytic astrocytoma10.1GFAP
27spitz nevus10.1BRAF
28melanotic neuroectodermal tumor10.1SYP
29congenital mesoblastic nephroma10.1SMARCB1
30alexander disease10.1GFAP
31adult acute lymphocytic leukemia10.1CDKN2B
32pineocytoma10.1SYP, GFAP
33pineoblastoma10.1SYP, GFAP
34papillary ependymoma10.1SYP, GFAP
35binswanger's disease10.1SYP, GFAP
36perineurioma10.1CD34
37central neurocytoma10.1GFAP, SYP
38choroid plexus papilloma10.1SYP, GFAP
39gliosarcoma10.1GFAP, CDK4
40subependymal giant cell astrocytoma10.1TSC1, SYP
41granular cell tumor10.1CD68, SYP
42oligoastrocytoma10.1MGMT, GFAP
43anaplastic ependymoma10.1MDM2, GFAP
44cutaneous fibrous histiocytoma10.1CD68, CD34
45epithelioid sarcoma10.1SMARCB1, CD34
46actinic keratosis10.1TP53
47tuberous sclerosis10.1GFAP, TSC1, SYP
48hemangioblastoma10.1GFAP, SYP
49neurilemmoma10.1CD34, GFAP, SMARCB1
50dedifferentiated liposarcoma10.1MDM2, CDK4

Graphical network of the top 20 diseases related to Pleomorphic Xanthoastrocytoma:



Diseases related to pleomorphic xanthoastrocytoma

Symptoms for Pleomorphic Xanthoastrocytoma

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Drugs & Therapeutics for Pleomorphic Xanthoastrocytoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Pleomorphic Xanthoastrocytoma

Drug clinical trials:

Search ClinicalTrials for Pleomorphic Xanthoastrocytoma

Search NIH Clinical Center for Pleomorphic Xanthoastrocytoma

Search CenterWatch for Pleomorphic Xanthoastrocytoma

Genetic Tests for Pleomorphic Xanthoastrocytoma

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Anatomical Context for Pleomorphic Xanthoastrocytoma

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34MalaCards
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MalaCards organs/tissues related to Pleomorphic Xanthoastrocytoma:

34
Brain, Spinal cord, Parietal lobe, Temporal lobe, Cerebellum, Pineal, Retina, Testes

Animal Models for Pleomorphic Xanthoastrocytoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pleomorphic Xanthoastrocytoma:

38 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.4TP53, BRAF, MDM2, CDKN2A, EGFR
2MP:00053888.3EGFR, CDKN2A, TSC1, BRAF, TP53
3MP:00053678.0TP53, BRAF, TSC1, MDM2, CDK4, CDKN2B
4MP:00053917.9SMARCB1, GFAP, TP53, BRAF, CDKN2A, CDK4
5MP:00028737.9GFAP, TP53, BRAF, SYP, MDM2, EGFR
6MP:00053867.9GFAP, TP53, BRAF, TSC1, MDM2, CDKN2A
7MP:00053707.7SMARCB1, TP53, BRAF, TSC1, MDM2, CDKN2A
8MP:00053817.7CDK4, CDKN2A, MDM2, BRAF, TP53, GFAP
9MP:00053857.7SMARCB1, GFAP, TP53, BRAF, TSC1, MDM2
10MP:00053697.6GFAP, TP53, BRAF, TSC1, MDM2, CDKN2A
11MP:00053797.6MGMT, TP53, BRAF, TSC1, CDKN2A, CDK4
12MP:00053807.6SMARCB1, TP53, BRAF, TSC1, MDM2, CDKN2A
13MP:00053897.4SMARCB1, TP53, EGFR, CDKN2B, CDK4, CDKN2A
14MP:00030127.2MGMT, TP53, SYP, MDM2, CDKN2A, CD68
15MP:00053787.2SMARCB1, GFAP, TP53, BRAF, TSC1, MDM2
16MP:00036317.1SMARCB1, GFAP, TP53, BRAF, TSC1, SYP
17MP:00107717.1TP53, BRAF, TSC1, MDM2, CDKN2A, CDK4
18MP:00053907.1TP53, BRAF, TSC1, MDM2, CDKN2A, CD68
19MP:00107686.7TP53, GFAP, SMARCB1, MGMT, BRAF, TSC1
20MP:00053846.7BRAF, TP53, GFAP, SMARCB1, TSC1, MDM2
21MP:00053766.7MGMT, SMARCB1, GFAP, TP53, BRAF, TSC1
22MP:00020066.6EGFR, MGMT, SMARCB1, TP53, BRAF, TSC1
23MP:00053976.4SMARCB1, TP53, BRAF, MDM2, CDKN2A, CD68
24MP:00053876.1BRAF, TP53, GFAP, SMARCB1, MDM2, CDKN2A

Publications for Pleomorphic Xanthoastrocytoma

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53PubMed
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Articles related to Pleomorphic Xanthoastrocytoma:

(show top 50)    (show all 189)
idTitleAuthorsYear
1
Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma. (24252190)
2013
2
Pleomorphic xanthoastrocytoma: magnetic resonance imaging findings in a series of cases with histopathological confirmation. (23249973)
2013
3
Atrial fibrillation as an uncommon presentation in a large pleomorphic xanthoastrocytoma. (22086138)
2012
4
Cerebral pleomorphic xanthoastrocytoma associated with NF1: an updated review with a rare atypical case from Africa. (22020543)
2012
5
Patterns of care and outcomes of patients with pleomorphic xanthoastrocytoma: a SEER analysis. (22843450)
2012
6
Pleomorphic xanthoastrocytoma - a clinico-pathological review. (22101999)
2011
7
Pleomorphic xanthoastrocytoma and oligodendroglioma: collision of 2 morphologically and genetically distinct anaplastic components. (21214337)
2011
8
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. (21274720)
2011
9
Temporal lobe pleomorphic xanthoastrocytoma and acquired BRAF mutation in an adolescent with the constitutional 22q11.2 deletion syndrome. (20730472)
2011
10
Primary spinal pleomorphic xanthoastrocytoma. (21045509)
2010
11
Pleomorphic xanthoastrocytoma presenting with life-threatening hemorrhage in a child. (19278318)
2009
12
Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma. (19099200)
2009
13
Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis--a pediatric case report and review of the literature. (19326050)
2009
14
Rapid progression of early delayed radiation effect in pleomorphic xanthoastrocytoma. (20062573)
2009
15
Pleomorphic xanthoastrocytoma in elderly patients may portend a poor prognosis. (18255294)
2008
16
Temporal pleomorphic xanthoastrocytoma with glycogen accumulation--case report. (18666439)
2008
17
Pleomorphic xanthoastrocytoma with an intracystic hemorrhage : a case report and literature review. (19096580)
2007
18
Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma. (17431546)
2007
19
Cerebellar pleomorphic xanthoastrocytoma: case report and literature review. (17537486)
2007
20
Unusual recurrence of pleomorphic xanthoastrocytoma. (17439101)
2006
21
Multicentric pleomorphic xanthoastrocytoma in a patient with neurofibromatosis type 1. Case report and review of the literature. (15739569)
2005
22
Pleomorphic xanthoastrocytoma with anaplastic features presenting without GFAP immunoreactivity: implications for differential diagnosis. (16193842)
2005
23
Cerebral anaplastic pleomorphic xanthoastrocytoma with meningeal dissemination at first presentation. (14669022)
2004
24
Unique presentation of pleomorphic xanthoastrocytoma as a lytic skull lesion in an eight-year-old girl. (12411717)
2002
25
The use of chemotherapy to facilitate surgical resection in pleomorphic xanthoastrocytoma: experience in a single case. (11585332)
2001
26
Evaluation of pleomorphic xanthoastrocytoma by use of positron emission tomography with. (11156775)
2001
27
Pigmented pleomorphic xanthoastrocytoma: report of a rare case with review of the literature. (11371237)
2001
28
Combined oligodendroglioma/pleomorphic xanthoastrocytoma: a probable collision tumor: case report. (11383742)
2001
29
Cerebellar pleomorphic xanthoastrocytoma in an infant. (10504553)
1999
30
Pleomorphic xanthoastrocytoma with CT and MRI appearance of meningioma. (9987765)
1999
31
Pleomorphic xanthoastrocytoma: what do we really know about it? (10223246)
1999
32
Fatal pleomorphic xanthoastrocytoma with meningeal gliomatosis. (9602336)
1998
33
Atypical pleomorphic xanthoastrocytoma. (10192056)
1998
34
Late sequelae of treated pleomorphic xanthoastrocytoma: malignant brain stem astrocytoma occurring 15 years after radiation therapy. (9049863)
1997
35
Pleomorphic xanthoastrocytoma with gangliogliomatous component. (9521020)
1997
36
Clinical, radiological, and therapeutic features of pleomorphic xanthoastrocytoma: report of three patients and review of the literature. (8648341)
1996
37
Molecular genetic alterations in pleomorphic xanthoastrocytoma. (8834542)
1996
38
PET-FDG of pleomorphic xanthoastrocytoma. (7799091)
1995
39
Pleomorphic xanthoastrocytoma: report of two cases and brief review of the literature. (8477554)
1993
40
Pleomorphic xanthoastrocytoma associated with von Recklinghausen neurofibromatosis. (8481944)
1993
41
Pleomorphic xanthoastrocytoma: the birth of a diagnosis and a concept. (8293186)
1993
42
Pleomorphic xanthoastrocytoma, a distinctive astroglial tumor: neuroradiologic and pathologic features. (8279337)
1993
43
Telomeric associations evolving to ring chromosomes in a recurrent pleomorphic xanthoastrocytoma. (1606558)
1992
44
Pleomorphic xanthoastrocytoma: an immunohistochemical study of three cases. (1563714)
1992
45
Pleomorphic xanthoastrocytoma as a component of a cerebellar ganglioglioma: case report. (1513442)
1992
46
Temporal lobe tumor demonstrating ganglioglioma and pleomorphic xanthoastrocytoma components. Case report. (1607956)
1992
47
Pleomorphic xanthoastrocytoma. Ultrastructural, immunohistochemical, and DNA cytofluorometric study of a case. (1855184)
1991
48
Glioblastoma multiforme masquerading as a pleomorphic xanthoastrocytoma. (2547522)
1989
49
Pleomorphic xanthoastrocytoma. Immunohistochemical methods for differentiation from fibrous histiocytomas with similar morphology. (3010749)
1986
50
Pleomorphic xanthoastrocytoma: a report of two cases. (6687296)
1983

Variations for Pleomorphic Xanthoastrocytoma

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Expression for genes affiliated with Pleomorphic Xanthoastrocytoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleomorphic Xanthoastrocytoma

Search GEO for disease gene expression data for Pleomorphic Xanthoastrocytoma.

Pathways for genes affiliated with Pleomorphic Xanthoastrocytoma

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Sources:
51PathCards, 13EMD Millipore, 61Thomson Reuters, 31KEGG, 54QIAGEN, 58SinoBiological, 39NCBI BioSystems Database, 56Reactome, 62Tocris Bioscience, 52PharmGKB, 5Cell Signaling Technology, 55R&D Systems
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Pathways related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Neurofilaments61
9.6SYNM, GFAP, TUBB
2
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation61
9.4CDKN2A, CDK4, CDKN2B
39.4TP53, CDK4, CDKN2B
4
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.3MDM2, TSC1, TP53
59.3MGMT, TP53, CDK4
6
Show member pathways
9.3TP53, MDM2, CDK4
7
Show member pathways
9.3TP53, MDM2, CDK4
89.3CDK4, MDM2, TP53
99.3CDK4, MDM2, TP53
10
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion61
Pathogenic Escherichia coli infection39
9.1TUBB, BRAF, EGFR
119.1CDKN2A, MDM2, TP53
12
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.1CDKN2A, MDM2, TP53
139.1TP53, MDM2, CDKN2A
14
Show member pathways
9.1TP53, MDM2, CDKN2A
15
Show member pathways
9.1MDM2, CDKN2A, CDK4, CDKN2B
169.0EGFR, BRAF, TP53
17
Show member pathways
9.0TP53, BRAF, EGFR
18
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.0CDK4, MDM2, TSC1, TP53
199.0TP53, MDM2, EGFR
209.0EGFR, MDM2, TP53
21
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
8.9EGFR, CDKN2B, MDM2, BRAF
228.9TP53, CDKN2A, CDK4, CDKN2B
23
Show member pathways
8.9CDKN2B, CDK4, CDKN2A, TP53
248.8TP53, BRAF, MDM2, CDKN2A
25
Show member pathways
DNA damage response39
8.8TP53, MDM2, CDKN2A, CDK4
268.8CDK4, CDKN2A, MDM2, TP53
278.8EGFR, CDK4, TP53, GFAP
288.7TP53, BRAF, MDM2, EGFR
29
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
8.7TP53, BRAF, MDM2, EGFR
30
Show member pathways
Signal transduction PTEN pathway61
8.7TP53, BRAF, MDM2, EGFR
31
Show member pathways
8.7EGFR, MDM2, BRAF, TP53
32
Show member pathways
8.5TP53, MDM2, CDKN2A, CDK4, CDKN2B
33
Show member pathways
Cell cycle39
8.5TP53, MDM2, CDKN2A, CDK4, CDKN2B
348.5TP53, MDM2, CDKN2A, CDK4, CDKN2B
358.5TP53, MDM2, CDKN2A, CDK4, CDKN2B
368.5EGFR, CDKN2A, MDM2, TP53
37
Show member pathways
8.5MGMT, TP53, MDM2, CDKN2A, CDK4
388.4TP53, MDM2, CDK4, CDKN2B, EGFR
398.4TP53, TSC1, MDM2, CDK4, EGFR
408.4TP53, TSC1, MDM2, CDK4, EGFR
41
Show member pathways
8.2EGFR, CDKN2A, MDM2, BRAF, TP53
42
Show member pathways
8.1TUBB, TP53, MDM2, CDKN2A, CDK4, CDKN2B
438.1TP53, BRAF, TSC1, MDM2, CDK4, EGFR
44
Show member pathways
7.9TP53, BRAF, MDM2, CDKN2A, CDK4, EGFR
45
Show member pathways
7.9GFAP, TP53, BRAF, TSC1, MDM2, CDKN2B
46
Show member pathways
7.6TP53, BRAF, MDM2, CDKN2A, CDK4, CDKN2B
477.6TP53, BRAF, MDM2, CDKN2A, CDK4, CDKN2B
48
Show member pathways
Signaling Pathways in Glioblastoma39
7.3TP53, BRAF, TSC1, MDM2, CDKN2A, CDK4
497.3EGFR, MGMT, TP53, BRAF, TSC1, MDM2
50
Show member pathways
7.1GFAP, TP53, BRAF, TSC1, MDM2, CDKN2A

Compounds for genes affiliated with Pleomorphic Xanthoastrocytoma

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 3BitterDB
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Compounds related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1reticulin469.5SYP, GFAP, CD34
2dutp469.4MDM2, TP53, GFAP, SYP
3acnu469.4MGMT, TP53, CDKN2A
4sodium bisulfite469.4CDKN2A, MGMT, CDKN2B
55-methylcytosine46 2510.3MGMT, TP53, CDKN2A, CDKN2B
6hematoxylin469.2CD34, CDKN2A, SYP, GFAP
7chlorambucil46 1210.2MGMT, TP53, MDM2
8crcs469.2CDKN2A, MGMT, TP53, BRAF
9silver469.2CDKN2A, CD34, SYP, GFAP
10depsipeptide469.1BRAF, CDKN2A, TP53, TUBB
11roscovitine469.1CDKN2A, TP53, CDK4, MDM2
12o6-methylguanine469.0CDKN2B, BRAF, TP53, MGMT, CDKN2A
137,12-dimethylbenz(a)anthracene469.0MGMT, CDKN2A, MDM2
14temozolomide46 129.9MGMT, EGFR, TP53, CDKN2A
15valine468.9CDKN2A, TUBB, BRAF, MDM2, CDK4
16camptothecin46 62 1210.8TP53, MDM2, CDKN2A, CDK4, MGMT
175-aza-2deoxycytidine468.8TP53, MGMT, MDM2, CDKN2A, CDKN2B
18cyclic amp46 259.8CDKN2A, GFAP, BRAF, SYP, CDK4, MDM2
19vincristine46 52 1210.7CDKN2A, TP53, TUBB, MGMT, MDM2
20geldanamycin46 52 62 1211.7BRAF, MDM2, CDK4, EGFR, TP53
21bcnu468.7CDKN2A, EGFR, MGMT, GFAP, TP53
22carboplatin46 52 1210.7MGMT, CDK4, TP53, MDM2, EGFR
23flavopiridol46 129.6EGFR, CDK4, CDKN2A, MDM2, TP53
24curcumin468.6CDK4, EGFR, MDM2, TP53, MGMT
25egcg468.6MGMT, TP53, CDK4, CDKN2A, EGFR
26adpribose468.5EGFR, CDK4, MDM2, TP53
27pd 98,059468.5MDM2, EGFR, CDKN2B, CDK4, GFAP, BRAF
28docetaxel46 52 62 1211.4TP53, MDM2, CDKN2A, EGFR, TUBB
29alanine468.3TUBB, CDK4, MDM2, TSC1, BRAF, CDKN2A
30genistein46 30 62 3 25 1213.3EGFR, MGMT, GFAP, SYP, MDM2, CDKN2A
31irinotecan46 52 1210.3EGFR, MGMT, TP53, BRAF, MDM2, CDKN2A
325fluorouracil468.2CDK4, EGFR, MDM2, TP53, MGMT, CDKN2A
33cysteine468.2MGMT, CDK4, CDKN2A, MDM2, SYP, GFAP
34threonine468.2TUBB, TSC1, BRAF, MDM2, CDK4, GFAP
35testosterone46 62 25 1211.2SYP, MDM2, CDKN2A, CDK4, EGFR, GFAP
36doxorubicin46 52 1210.2EGFR, CDK4, MGMT, TP53, CDKN2A, MDM2
37thymidine46 259.1MDM2, TP53, GFAP, CD34, MGMT, TUBB
38cycloheximide468.1CDKN2A, CDK4, EGFR, MDM2, TP53, GFAP
39oligonucleotide468.1BRAF, TP53, MDM2, CDK4, CDKN2A, MGMT
40agar468.0GFAP, BRAF, MDM2, CDK4, CD34, EGFR
41thymidylate467.9EGFR, CDK4, CDKN2A, MDM2, MGMT, TUBB
42paclitaxel46 52 129.3MGMT, BRAF, EGFR, CDK4, CDKN2A, MDM2
43tyrosine467.3BRAF, TSC1, GFAP, TUBB, EGFR, CD34
44cisplatin46 52 62 1210.1MDM2, TP53, BRAF, SYP, CDK4, EGFR
45retinoic acid46 258.1SYP, CDK4, TP53, MGMT, GFAP, BRAF
46progesterone46 30 62 25 1211.0EGFR, CD34, CDK4, CDKN2A, TP53, MGMT
47serine466.9CDKN2A, GFAP, TP53, TUBB, EGFR, CDKN2B
48vegf466.7GFAP, MGMT, TP53, BRAF, TSC1, SYP
49estrogen466.3EGFR, CD34, CDKN2B, CDK4, CDKN2A, MDM2
50paraffin465.5CD34, TP53, BRAF, TUBB, MGMT, TSC1

GO Terms for genes affiliated with Pleomorphic Xanthoastrocytoma

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17Gene Ontology
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Cellular components related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.2TP53, MDM2, CDKN2A
2protein complexGO:0432348.8CDKN2A, MDM2, SYP, TSC1, TP53
3nucleoplasmGO:0056548.3MGMT, SMARCB1, TP53, MDM2, CDKN2A, CDK4
4membraneGO:0160208.3GFAP, TSC1, SYNM, CD68, EGFR
5nucleolusGO:0057308.0SMARCB1, TP53, MDM2, CDKN2A, CDK4, CDKN2B
6cytosolGO:0058297.4TUBB, GFAP, TP53, BRAF, TSC1, MDM2
7cytoplasmGO:0057377.2TP53, TSC1, MDM2, CDKN2A, CDKN2B, CD34
8nucleusGO:0056346.9MGMT, SMARCB1, TP53, BRAF, MDM2, CDKN2A

Biological processes related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:07115710.0CDK4, MDM2
2negative regulation of phosphorylationGO:0423269.8CDKN2B, CDKN2A
3replicative senescenceGO:0903999.8CDKN2A, TP53
4protein destabilizationGO:0316489.7MDM2, CDKN2A
5positive regulation of cell cycle arrestGO:0711589.6TP53, CDKN2A
6cellular response to organic substanceGO:0713109.6SYP, CD68
7cellular response to ionizing radiationGO:0714799.6TP53, MGMT
8positive regulation of gene expressionGO:0106289.5CD34, MDM2, BRAF
9mitotic cell cycleGO:0002789.3TUBB, CDKN2A, CDK4, CDKN2B
10cell cycle arrestGO:0070509.2CDKN2B, CDKN2A, TSC1, TP53
11positive regulation of DNA repairGO:0457399.2EGFR, MGMT
12fibroblast growth factor receptor signaling pathwayGO:0085439.1BRAF, MDM2, EGFR
13negative regulation of cell proliferationGO:0082859.0SMARCB1, TP53, TSC1, CDKN2A, CDKN2B
14negative regulation of apoptotic processGO:0430668.8EGFR, MDM2, BRAF, TP53
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.6SMARCB1, TP53, CDKN2A, CDKN2B, EGFR

Molecular functions related to Pleomorphic Xanthoastrocytoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.8CDKN2B, CDKN2A
2GTPase activating protein bindingGO:0327949.7TSC1, TUBB
3structural constituent of cytoskeletonGO:0052009.6TUBB, GFAP, SYNM
4MDM2/MDM4 family protein bindingGO:0973719.6TP53, CDKN2A
5protein complex bindingGO:0324039.5CDK4, SYP, TUBB
6MAP kinase kinase kinase activityGO:0047099.3BRAF, EGFR
7p53 bindingGO:0020399.1CDKN2A, MDM2, TP53, SMARCB1
8protein kinase bindingGO:0199018.7EGFR, CDKN2B, CDKN2A, TP53
9identical protein bindingGO:0428028.6TP53, BRAF, SYP, MDM2, EGFR
10protein bindingGO:0055156.6TUBB, SMARCB1, TP53, BRAF, TSC1, SYNM

Products for genes affiliated with Pleomorphic Xanthoastrocytoma

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Sources for Pleomorphic Xanthoastrocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet