MCID: PLM020
MIFTS: 49

Pleomorphic Xanthoastrocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Pleomorphic Xanthoastrocytoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 61UMLS, 56SNOMED-CT, 39NCIt, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Pleomorphic Xanthoastrocytoma:

Name: Pleomorphic Xanthoastrocytoma 8 42 48 61
Pxa 42 48
 
Pleomorphic Xantho-Astrocytoma 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
pleomorphic xanthoastrocytoma:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology8 DOID:4852
NCIt39 C4323
SNOMED-CT56 189924002, 78838008
Orphanet48 251607
UMLS via Orphanet62 C0334586

Summaries for Pleomorphic Xanthoastrocytoma

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Wikipedia:64 Pleomorphic Xanthoastrocytoma is a neoplasm of the brain that most frequently occurs in children and... more...

MalaCards based summary: Pleomorphic Xanthoastrocytoma, also known as pxa, is related to dysembryoplastic neuroepithelial tumor and ganglioglioma. An important gene associated with Pleomorphic Xanthoastrocytoma is SYP (synaptophysin), and among its related pathways are Cytoplasmic microtubules and Cell cycle Regulation of G1 S transition part 1 . The compounds reticulin and dutp have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and parietal lobe, and related mouse phenotypes are pigmentation and respiratory system.

Related Diseases for Pleomorphic Xanthoastrocytoma

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Diseases related to Pleomorphic Xanthoastrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1dysembryoplastic neuroepithelial tumor31.4SYP
2ganglioglioma31.2SYP, TSC1, GFAP, TUBB
3rhabdoid tumor31.1SYP, SMARCB1
4fibrous histiocytoma31.1CD34
5giant cell glioblastoma30.8GFAP, MDM2, EGFR
6tuberous sclerosis30.8GFAP, TSC1, SYP
7pilocytic astrocytoma30.4CDK4, SYP, TSC1, GFAP, MGMT
8oligodendroglioma30.0MGMT, GFAP, BRAF, CDKN2A, CDKN2B, EGFR
9glioblastoma29.1MGMT, TUBB, SMARCB1, GFAP, TP53, MDM2
10astrocytoma29.1SYP, MDM2, CDKN2A, CDK4, CDKN2B, EGFR
11glioblastoma multiforme29.1MGMT, GFAP, TP53, TSC1, MDM2, CDKN2A
12neurofibromatosis10.7
13neurofibromatosis, type 110.6
14gliomatosis cerebri10.6GFAP
15choroid plexus carcinoma10.6SMARCB1
16glomus tumor10.6SYP
17cerebritis10.6
18gemistocytic astrocytoma10.6GFAP
19spitz nevus10.5BRAF
20melanotic neuroectodermal tumor10.5SYP
21neuronitis10.5
22congenital mesoblastic nephroma10.5SMARCB1
23alexander disease10.5GFAP
24adult acute lymphocytic leukemia10.5CDKN2B
25pineocytoma10.5SYP, GFAP
26pineoblastoma10.5SYP, GFAP
27meningitis10.5
28papillary ependymoma10.4SYP, GFAP
29binswanger's disease10.4SYP, GFAP
30perineurioma10.4CD34
31central neurocytoma10.4GFAP, SYP
32choroid plexus papilloma10.4SYP, GFAP
33gliosarcoma10.4GFAP, CDK4
34subependymal giant cell astrocytoma10.4TSC1, SYP
35granular cell tumor10.4CD68, SYP
36atypical teratoid rhabdoid tumor10.4
37arteriovenous malformation10.4
38oligoastrocytoma10.4MGMT, GFAP
39anaplastic ependymoma10.4MDM2, GFAP
40cutaneous fibrous histiocytoma10.4CD68, CD34
41epithelioid sarcoma10.4SMARCB1, CD34
42hemangioblastoma10.3GFAP, SYP
43actinic keratosis10.3TP53
44connective tissue benign neoplasm10.3MDM2, CDK4
45neurilemmoma10.3CD34, GFAP, SMARCB1
46dedifferentiated liposarcoma10.3MDM2, CDK4
47myxoid liposarcoma10.3MDM2, CDK4
48chondrosarcoma10.3MDM2, CDK4
49fibroma10.3TSC1, CD34
50ganglioneuroma10.3SYP, GFAP

Graphical network of the top 20 diseases related to Pleomorphic Xanthoastrocytoma:



Diseases related to pleomorphic xanthoastrocytoma

Symptoms for Pleomorphic Xanthoastrocytoma

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Drugs & Therapeutics for Pleomorphic Xanthoastrocytoma

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Drug clinical trials:

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Genetic Tests for Pleomorphic Xanthoastrocytoma

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Anatomical Context for Pleomorphic Xanthoastrocytoma

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MalaCards organs/tissues related to Pleomorphic Xanthoastrocytoma:

31
Brain, Spinal cord, Parietal lobe, Temporal lobe, Pineal, Cerebellum, Retina, Testes, Medulla oblongata

Animal Models for Pleomorphic Xanthoastrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Pleomorphic Xanthoastrocytoma:

35 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.4TP53, EGFR, CDKN2A, MDM2, BRAF
2MP:00053888.3TP53, CDKN2A, TSC1, BRAF, EGFR
3MP:00053678.0TP53, BRAF, TSC1, MDM2, CDK4, EGFR
4MP:00053917.9EGFR, CDK4, CDKN2A, BRAF, TP53, GFAP
5MP:00028737.9EGFR, GFAP, TP53, BRAF, SYP, MDM2
6MP:00053867.9BRAF, TSC1, MDM2, CDKN2A, TP53, GFAP
7MP:00053707.7CDK4, CDKN2A, MDM2, TSC1, BRAF, TP53
8MP:00053817.7BRAF, TP53, GFAP, SMARCB1, MDM2, CDK4
9MP:00053857.7TSC1, EGFR, SMARCB1, GFAP, TP53, BRAF
10MP:00053697.6EGFR, CDK4, MDM2, TSC1, CDKN2A, GFAP
11MP:00053797.6TSC1, EGFR, CDKN2B, TP53, CDK4, BRAF
12MP:00053807.6SMARCB1, BRAF, EGFR, CDK4, CDKN2A, MDM2
13MP:00053897.4CDKN2A, MDM2, TSC1, BRAF, TP53, SMARCB1
14MP:00030127.2MGMT, EGFR, CDKN2B, TP53, CD68, CDKN2A
15MP:00053787.2CDK4, BRAF, TSC1, MDM2, CDKN2A, EGFR
16MP:00036317.1CDK4, TP53, BRAF, SMARCB1, GFAP, TSC1
17MP:00107717.1CDKN2A, EGFR, CD34, BRAF, TSC1, TP53
18MP:00053907.1EGFR, CD68, MDM2, TSC1, BRAF, TP53
19MP:00107686.7SMARCB1, BRAF, MDM2, CDKN2A, TSC1, TP53
20MP:00053846.7TP53, EGFR, CD34, CDKN2B, CDK4, MDM2
21MP:00053766.7TP53, GFAP, SMARCB1, MGMT, BRAF, TSC1
22MP:00020066.6CD34, CDKN2B, CDK4, CDKN2A, MDM2, TSC1
23MP:00053976.4BRAF, CD34, CDKN2B, CDK4, CD68, EGFR
24MP:00053876.1CDK4, EGFR, GFAP, SMARCB1, BRAF, TP53

Publications for Pleomorphic Xanthoastrocytoma

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Articles related to Pleomorphic Xanthoastrocytoma:

(show top 50)    (show all 209)
idTitleAuthorsYear
1
Successful Treatment of a Progressive BRAF V600E-Mutated Anaplastic Pleomorphic Xanthoastrocytoma With Vemurafenib Monotherapy. (25092772)
2014
2
Pleomorphic Xanthoastrocytoma: Natural History and Long-term Follow-up. (25318587)
2014
3
Intraventricular pleomorphic xanthoastrocytoma: a case report. (25448222)
2014
4
Pleomorphic Xanthoastrocytoma Within the Medulla Oblongata of a Young Dog. (24686391)
2014
5
Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression. (23442159)
2013
6
Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma. (24252190)
2013
7
Pleomorphic xanthoastrocytoma: magnetic resonance imaging findings in a series of cases with histopathological confirmation. (23249973)
2013
8
Atrial fibrillation as an uncommon presentation in a large pleomorphic xanthoastrocytoma. (22086138)
2012
9
Cerebral pleomorphic xanthoastrocytoma associated with NF1: an updated review with a rare atypical case from Africa. (22020543)
2012
10
Patterns of care and outcomes of patients with pleomorphic xanthoastrocytoma: a SEER analysis. (22843450)
2012
11
Pleomorphic xanthoastrocytoma - a clinico-pathological review. (22101999)
2011
12
Pleomorphic xanthoastrocytoma and oligodendroglioma: collision of 2 morphologically and genetically distinct anaplastic components. (21214337)
2011
13
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. (21274720)
2011
14
Temporal lobe pleomorphic xanthoastrocytoma and acquired BRAF mutation in an adolescent with the constitutional 22q11.2 deletion syndrome. (20730472)
2011
15
Primary spinal pleomorphic xanthoastrocytoma. (21045509)
2010
16
Pleomorphic xanthoastrocytoma presenting with life-threatening hemorrhage in a child. (19278318)
2009
17
Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma. (19099200)
2009
18
Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis--a pediatric case report and review of the literature. (19326050)
2009
19
Rapid progression of early delayed radiation effect in pleomorphic xanthoastrocytoma. (20062573)
2009
20
Pleomorphic xanthoastrocytoma in elderly patients may portend a poor prognosis. (18255294)
2008
21
Temporal pleomorphic xanthoastrocytoma with glycogen accumulation--case report. (18666439)
2008
22
Pleomorphic xanthoastrocytoma with an intracystic hemorrhage : a case report and literature review. (19096580)
2007
23
Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma. (17431546)
2007
24
Cerebellar pleomorphic xanthoastrocytoma: case report and literature review. (17537486)
2007
25
Unusual recurrence of pleomorphic xanthoastrocytoma. (17439101)
2006
26
Multicentric pleomorphic xanthoastrocytoma in a patient with neurofibromatosis type 1. Case report and review of the literature. (15739569)
2005
27
Pleomorphic xanthoastrocytoma with anaplastic features presenting without GFAP immunoreactivity: implications for differential diagnosis. (16193842)
2005
28
The use of chemotherapy to facilitate surgical resection in pleomorphic xanthoastrocytoma: experience in a single case. (11585332)
2001
29
Evaluation of pleomorphic xanthoastrocytoma by use of positron emission tomography with. (11156775)
2001
30
Pigmented pleomorphic xanthoastrocytoma: report of a rare case with review of the literature. (11371237)
2001
31
Combined oligodendroglioma/pleomorphic xanthoastrocytoma: a probable collision tumor: case report. (11383742)
2001
32
Cerebellar pleomorphic xanthoastrocytoma in an infant. (10504553)
1999
33
Pleomorphic xanthoastrocytoma with CT and MRI appearance of meningioma. (9987765)
1999
34
Pleomorphic xanthoastrocytoma: what do we really know about it? (10223246)
1999
35
Fatal pleomorphic xanthoastrocytoma with meningeal gliomatosis. (9602336)
1998
36
Late sequelae of treated pleomorphic xanthoastrocytoma: malignant brain stem astrocytoma occurring 15 years after radiation therapy. (9049863)
1997
37
Pleomorphic xanthoastrocytoma with gangliogliomatous component. (9521020)
1997
38
Clinical, radiological, and therapeutic features of pleomorphic xanthoastrocytoma: report of three patients and review of the literature. (8648341)
1996
39
Molecular genetic alterations in pleomorphic xanthoastrocytoma. (8834542)
1996
40
PET-FDG of pleomorphic xanthoastrocytoma. (7799091)
1995
41
Pleomorphic xanthoastrocytoma: report of two cases and brief review of the literature. (8477554)
1993
42
Pleomorphic xanthoastrocytoma associated with von Recklinghausen neurofibromatosis. (8481944)
1993
43
Pleomorphic xanthoastrocytoma: the birth of a diagnosis and a concept. (8293186)
1993
44
Telomeric associations evolving to ring chromosomes in a recurrent pleomorphic xanthoastrocytoma. (1606558)
1992
45
Pleomorphic xanthoastrocytoma: an immunohistochemical study of three cases. (1563714)
1992
46
Pleomorphic xanthoastrocytoma as a component of a cerebellar ganglioglioma: case report. (1513442)
1992
47
Temporal lobe tumor demonstrating ganglioglioma and pleomorphic xanthoastrocytoma components. Case report. (1607956)
1992
48
Glioblastoma multiforme masquerading as a pleomorphic xanthoastrocytoma. (2547522)
1989
49
Pleomorphic xanthoastrocytoma. Immunohistochemical methods for differentiation from fibrous histiocytomas with similar morphology. (3010749)
1986
50
Pleomorphic xanthoastrocytoma: a report of two cases. (6687296)
1983

Variations for Pleomorphic Xanthoastrocytoma

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Expression for genes affiliated with Pleomorphic Xanthoastrocytoma

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Search GEO for disease gene expression data for Pleomorphic Xanthoastrocytoma.

Pathways for genes affiliated with Pleomorphic Xanthoastrocytoma

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Pathways related to Pleomorphic Xanthoastrocytoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation59
9.4CDKN2B, CDK4, CDKN2A
29.4CDK4, CDKN2B, TP53
3
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway59
Signal transduction AKT signaling59
9.3TSC1, MDM2, TP53
49.3CDK4, MDM2, TP53
59.3CDK4, MDM2, TP53
6
Show member pathways
9.3MDM2, TP53, CDK4
7
Show member pathways
9.3CDK4, TP53, MDM2
8
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion59
Pathogenic Escherichia coli infection36
Cytoskeleton remodeling Slit Robo signaling
9.1TUBB, EGFR, BRAF
9
Show member pathways
9.1TP53, MDM2, CDKN2A
109.1CDKN2A, MDM2, TP53
11
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.1CDKN2A, TP53, MDM2
129.1MDM2, TP53, CDKN2A
13
Show member pathways
9.1CDK4, CDKN2B, CDKN2A, MDM2
149.0BRAF, TP53, EGFR
15
Show member pathways
9.0TP53, EGFR, BRAF
16
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.0CDK4, MDM2, TSC1, TP53
179.0TP53, MDM2, EGFR
189.0EGFR, MDM2, TP53
19
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
8.9MDM2, EGFR, CDKN2B, BRAF
208.9CDKN2B, TP53, CDKN2A, CDK4
21
Show member pathways
8.9CDKN2A, CDK4, TP53, CDKN2B
228.8CDKN2A, MDM2, BRAF, TP53
238.8TP53, MDM2, CDKN2A, CDK4
24
Show member pathways
DNA damage response36
8.8CDK4, MDM2, TP53, CDKN2A
258.8TP53, EGFR, GFAP, CDK4
26
Show member pathways
8.7TP53, BRAF, MDM2, EGFR
278.7BRAF, EGFR, TP53, MDM2
28
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
8.7EGFR, MDM2, BRAF, TP53
29
Show member pathways
Signal transduction PTEN pathway59
8.7EGFR, TP53, BRAF, MDM2
308.5CDKN2A, CDK4, CDKN2B, TP53, MDM2
318.5CDK4, CDKN2B, CDKN2A, MDM2, TP53
32
Show member pathways
8.5TP53, CDK4, CDKN2A, MDM2, CDKN2B
33
Show member pathways
Cell cycle36
8.5CDKN2B, TP53, MDM2, CDK4, CDKN2A
348.5MDM2, CDKN2A, EGFR, TP53
35
Show member pathways
8.5MDM2, MGMT, CDKN2A, CDK4, TP53
368.4TP53, CDKN2B, CDK4, EGFR, MDM2
378.4TP53, TSC1, MDM2, CDK4, EGFR
388.4EGFR, CDK4, MDM2, TSC1, TP53
39
Show member pathways
8.2TP53, BRAF, MDM2, CDKN2A, EGFR
40
Show member pathways
8.1TP53, CDKN2A, MDM2, CDK4, CDKN2B, TUBB
418.1TP53, BRAF, TSC1, MDM2, CDK4, EGFR
42
Show member pathways
7.9EGFR, CDK4, CDKN2A, MDM2, BRAF, TP53
43
Show member pathways
7.9EGFR, MDM2, TSC1, BRAF, CDKN2B, GFAP
447.6CDKN2A, BRAF, MDM2, CDK4, CDKN2B, EGFR
45
Show member pathways
7.6EGFR, TP53, BRAF, MDM2, CDKN2B, CDK4
46
Show member pathways
Signaling Pathways in Glioblastoma36
7.3CDKN2A, MDM2, TSC1, BRAF, TP53, EGFR
477.3EGFR, CDK4, CDKN2A, MDM2, TSC1, BRAF
48
Show member pathways
7.1GFAP, BRAF, TSC1, MDM2, CDKN2A, CDK4

Compounds for genes affiliated with Pleomorphic Xanthoastrocytoma

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Compounds related to Pleomorphic Xanthoastrocytoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1reticulin449.5SYP, GFAP, CD34
2dutp449.4MDM2, TP53, GFAP, SYP
3acnu449.4MGMT, TP53, CDKN2A
4sodium bisulfite449.4CDKN2A, MGMT, CDKN2B
55-methylcytosine44 2410.3MGMT, TP53, CDKN2A, CDKN2B
6hematoxylin449.2CD34, CDKN2A, SYP, GFAP
7chlorambucil44 1110.2MGMT, TP53, MDM2
8crcs449.2CDKN2A, MGMT, TP53, BRAF
9silver449.2CDKN2A, CD34, SYP, GFAP
10depsipeptide449.1BRAF, CDKN2A, TP53, TUBB
11roscovitine449.1CDKN2A, TP53, CDK4, MDM2
12o6-methylguanine449.0CDKN2B, BRAF, TP53, MGMT, CDKN2A
137,12-dimethylbenz(a)anthracene449.0MGMT, CDKN2A, MDM2
14temozolomide44 119.9MGMT, EGFR, TP53, CDKN2A
15valine448.9CDKN2A, TUBB, BRAF, MDM2, CDK4
16camptothecin44 60 1110.8TP53, MDM2, CDKN2A, CDK4, MGMT
175-aza-2deoxycytidine448.8TP53, MGMT, MDM2, CDKN2A, CDKN2B
18cyclic amp44 249.8CDKN2A, GFAP, BRAF, SYP, CDK4, MDM2
19vincristine44 50 1110.7CDKN2A, TP53, TUBB, MGMT, MDM2
20geldanamycin44 50 60 1111.7BRAF, MDM2, CDK4, EGFR, TP53
21bcnu448.7CDKN2A, EGFR, MGMT, GFAP, TP53
22carboplatin44 50 1110.7MGMT, CDK4, TP53, MDM2, EGFR
23flavopiridol44 119.6EGFR, CDK4, CDKN2A, MDM2, TP53
24curcumin448.6CDK4, EGFR, MDM2, TP53, MGMT
25egcg448.6MGMT, TP53, CDK4, CDKN2A, EGFR
26adpribose448.5EGFR, CDK4, MDM2, TP53
27pd 98,059448.5MDM2, EGFR, CDKN2B, CDK4, GFAP, BRAF
28docetaxel44 50 60 1111.4TP53, MDM2, CDKN2A, EGFR, TUBB
29alanine448.3TUBB, CDK4, MDM2, TSC1, BRAF, CDKN2A
30genistein44 28 60 1 24 1113.3EGFR, MGMT, GFAP, SYP, MDM2, CDKN2A
31irinotecan44 50 1110.3EGFR, MGMT, TP53, BRAF, MDM2, CDKN2A
325fluorouracil448.2CDK4, EGFR, MDM2, TP53, MGMT, CDKN2A
33cysteine448.2MGMT, CDK4, CDKN2A, MDM2, SYP, GFAP
34threonine448.2TUBB, TSC1, BRAF, MDM2, CDK4, GFAP
35testosterone44 60 24 1111.2SYP, MDM2, CDKN2A, CDK4, EGFR, GFAP
36doxorubicin44 50 1110.2EGFR, CDK4, MGMT, TP53, CDKN2A, MDM2
37thymidine44 249.1MDM2, TP53, GFAP, CD34, MGMT, TUBB
38cycloheximide448.1CDKN2A, CDK4, EGFR, MDM2, TP53, GFAP
39oligonucleotide448.1BRAF, TP53, MDM2, CDK4, CDKN2A, MGMT
40agar448.0GFAP, BRAF, MDM2, CDK4, CD34, EGFR
41thymidylate447.9EGFR, CDK4, CDKN2A, MDM2, MGMT, TUBB
42paclitaxel44 50 119.3MGMT, BRAF, EGFR, CDK4, CDKN2A, MDM2
43tyrosine447.3BRAF, TSC1, GFAP, TUBB, EGFR, CD34
44cisplatin44 50 60 1110.1MDM2, TP53, BRAF, SYP, CDK4, EGFR
45retinoic acid44 248.1SYP, CDK4, TP53, MGMT, GFAP, BRAF
46progesterone44 28 60 24 1111.0EGFR, CD34, CDK4, CDKN2A, TP53, MGMT
47serine446.9CDKN2A, GFAP, TP53, TUBB, EGFR, CDKN2B
48vegf446.7GFAP, MGMT, TP53, BRAF, TSC1, SYP
49estrogen446.3EGFR, CD34, CDKN2B, CDK4, CDKN2A, MDM2
50paraffin445.5CD34, TP53, BRAF, TUBB, MGMT, TSC1

GO Terms for genes affiliated with Pleomorphic Xanthoastrocytoma

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Cellular components related to Pleomorphic Xanthoastrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.2TP53, MDM2, CDKN2A
2protein complexGO:00432348.8CDKN2A, MDM2, SYP, TSC1, TP53
3nucleoplasmGO:00056548.3MGMT, SMARCB1, TP53, MDM2, CDKN2A, CDK4
4membraneGO:00160208.3GFAP, TSC1, SYNM, CD68, EGFR
5nucleolusGO:00057308.0SMARCB1, TP53, MDM2, CDKN2A, CDK4, CDKN2B
6cytosolGO:00058297.4TUBB, GFAP, TP53, BRAF, TSC1, MDM2
7cytoplasmGO:00057377.2TP53, TSC1, MDM2, CDKN2A, CDKN2B, CD34
8nucleusGO:00056346.9MGMT, SMARCB1, TP53, BRAF, MDM2, CDKN2A

Biological processes related to Pleomorphic Xanthoastrocytoma according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:007115710.0CDK4, MDM2
2negative regulation of phosphorylationGO:00423269.8CDKN2B, CDKN2A
3replicative senescenceGO:00903999.8CDKN2A, TP53
4protein destabilizationGO:00316489.7MDM2, CDKN2A
5positive regulation of cell cycle arrestGO:00711589.6TP53, CDKN2A
6cellular response to organic substanceGO:00713109.6SYP, CD68
7cellular response to ionizing radiationGO:00714799.6TP53, MGMT
8positive regulation of gene expressionGO:00106289.5CD34, MDM2, BRAF
9mitotic cell cycleGO:00002789.3TUBB, CDKN2A, CDK4, CDKN2B
10cell cycle arrestGO:00070509.2CDKN2B, CDKN2A, TSC1, TP53
11positive regulation of DNA repairGO:00457399.2EGFR, MGMT
12fibroblast growth factor receptor signaling pathwayGO:00085439.1BRAF, MDM2, EGFR
13negative regulation of cell proliferationGO:00082859.0SMARCB1, TP53, TSC1, CDKN2A, CDKN2B
14negative regulation of apoptotic processGO:00430668.8EGFR, MDM2, BRAF, TP53
15positive regulation of transcription from RNA polymerase II promoterGO:00459448.6SMARCB1, TP53, CDKN2A, CDKN2B, EGFR

Molecular functions related to Pleomorphic Xanthoastrocytoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048619.8CDKN2B, CDKN2A
2GTPase activating protein bindingGO:00327949.7TSC1, TUBB
3structural constituent of cytoskeletonGO:00052009.6TUBB, GFAP, SYNM
4MDM2/MDM4 family protein bindingGO:00973719.6TP53, CDKN2A
5protein complex bindingGO:00324039.5CDK4, SYP, TUBB
6MAP kinase kinase kinase activityGO:00047099.3BRAF, EGFR
7p53 bindingGO:00020399.1CDKN2A, MDM2, TP53, SMARCB1
8protein kinase bindingGO:00199018.7EGFR, CDKN2B, CDKN2A, TP53
9identical protein bindingGO:00428028.6TP53, BRAF, SYP, MDM2, EGFR
10protein bindingGO:00055156.6TUBB, SMARCB1, TP53, BRAF, TSC1, SYNM

Sources for Pleomorphic Xanthoastrocytoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet