Aliases & Classifications for Pleural Disease

MalaCards integrated aliases for Pleural Disease:

Name: Pleural Disease 12 14
Pleural Diseases 52 42 69
Non-Neoplastic Pleural Disorder 69
Non-Neoplastic Pleural Disease 12
Abnormality of the Pleura 29
Disorder of Pleura 12
Pleural Disorders 41

Classifications:



External Ids:

Disease Ontology 12 DOID:1532
MeSH 42 D010995
NCIt 47 C26859
SNOMED-CT 64 88075009
ICD10 33 J94.9 Q34.0
UMLS 69 C0032226

Summaries for Pleural Disease

MedlinePlus : 41 your pleura is a large, thin sheet of tissue that wraps around the outside of your lungs and lines the inside of your chest cavity. between the layers of the pleura is a very thin space. normally it's filled with a small amount of fluid. the fluid helps the two layers of the pleura glide smoothly past each other as your lungs breathe air in and out. disorders of the pleura include pleurisy - inflammation of the pleura that causes sharp pain with breathing pleural effusion - excess fluid in the pleural space pneumothorax - buildup of air or gas in the pleural space hemothorax - buildup of blood in the pleural space many different conditions can cause pleural problems. viral infection is the most common cause of pleurisy. the most common cause of pleural effusion is congestive heart failure. lung diseases, like copd, tuberculosis, and acute lung injury, cause pneumothorax. injury to the chest is the most common cause of hemothorax. treatment focuses on removing fluid, air, or blood from the pleural space, relieving symptoms, and treating the underlying condition. nih: national heart, lung, and blood institute

MalaCards based summary : Pleural Disease, also known as pleural diseases, is related to lymphoma and pleurisy, and has symptoms including pleuritic pain, coughing and dyspnea. An important gene associated with Pleural Disease is ADA (Adenosine Deaminase), and among its related pathways/superpathways are NF-kappaB Signaling and mTOR signaling pathway (KEGG). The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes, and related phenotypes are homeostasis/metabolism and cardiovascular system

Disease Ontology : 12 A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism.

Wikipedia : 72 Pleural tumors may be benign (i.e. solitary fibromas) or malignant in nature. Pleural Mesothelioma is a... more...

Related Diseases for Pleural Disease

Diseases related to Pleural Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
id Related Disease Score Top Affiliating Genes
1 lymphoma 29.7 ALB IL1B TNF
2 pleurisy 11.0
3 tabatznik syndrome 10.7 IL1B TNF
4 sternal cleft 10.7 IL1B TNF
5 congenital dyserythropoietic anemia 10.7 ALB TNF
6 liver rhabdomyosarcoma 10.7 ADA ALB
7 chylothorax, congenital 10.7
8 pulmonary hypertension 10.7 IL1B TNF
9 autoimmune oophoritis 10.6 MPO TNF
10 oral cavity carcinoma in situ 10.6 ADA ALB
11 acquired thrombocytopenia 10.6 IL1B KNG1 TNF
12 walker dyson syndrome 10.5 IL1B TNF
13 migraine with brainstem aura 10.5 MPO TNF
14 inflammatory bowel disease 3 10.5 ADA IL1B TNF
15 functional gastric disease 10.5 ADA CRP TNF
16 signet ring cell adenocarcinoma 10.5 CHI3L1 CRP TNF
17 idiopathic peripheral autonomic neuropathy 10.5 ADA ALB
18 cataract 10.5 ALB IL1B TNF
19 axillary adenitis 10.5 CRP IL1B
20 calciphylaxis 10.5 ALB IL1B KNG1
21 mikulicz disease 10.5 ALB IL1B TNF
22 broad ligament malignant neoplasm 10.4 ALB KLKB1 KNG1
23 megaloblastic anemia 10.4 CRP IL1B TNF
24 benign neonatal seizures 10.4 CRP IL1B TNF
25 familial mediterranean fever, ad 10.4 CRP IL1B TNF
26 urethral gland abscess 10.4 ADA CRP
27 diabetic encephalopathy 10.4 CHI3L1 CRP TNF
28 myeloid sarcoma 10.4 CRP IL1B TNF
29 patau syndrome 10.4 CRP IL1B TNF
30 breast disease 10.4 CRP IL1B TNF
31 muscle tissue disease 10.4 CHI3L1 CRP TNF
32 tumefactive multiple sclerosis 10.4 ADA ALOX5 TNF
33 atrophy of prostate 10.4 CRP IL1B TNF
34 neonatal period electroclinical syndrome 10.4 CRP IL1B TNF
35 pyelonephritis 10.4 CRP IL1B TNF
36 neovascular glaucoma 10.4 CRP KNG1 TNF
37 cannabis dependence 10.4 CRP MPO
38 capillary leak syndrome 10.4 ALB CRP
39 premature ovarian failure 12 10.4 ALB IL1B TNF
40 keratomalacia 10.4 CRP IL1B TNF
41 hyperpigmentation of eyelid 10.4 ALB IL1B TNF
42 mesenchymal cell neoplasm 10.4 CRP IL1B TNF
43 bacterial gastritis 10.4 CRP IL1B TNF
44 nodular ganglioneuroblastoma 10.4 CRP MPO
45 respiratory system disease 10.4 CRP IL1B TNF
46 synovium cancer 10.3 CRP IL1B TNF
47 plummer's disease 10.3 ALB CRP TNF
48 vulva fibroepithelial polyp 10.3 CRP IL1B TNF
49 scrotal carcinoma 10.3 IL1B TNF
50 benign mammary dysplasia 10.3 ALB CRP TNF

Graphical network of the top 20 diseases related to Pleural Disease:



Diseases related to Pleural Disease

Symptoms & Phenotypes for Pleural Disease

UMLS symptoms related to Pleural Disease:


pleuritic pain, coughing, dyspnea, snoring

MGI Mouse Phenotypes related to Pleural Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.93 ADA ALB ALOX5 CRP FLCN FNIP1
2 cardiovascular system MP:0005385 9.91 ADA ALOX5 CRP FLCN FNIP1 IL1B
3 immune system MP:0005387 9.7 TNF ADA ALOX5 CHI3L1 CRP CXCL13
4 neoplasm MP:0002006 9.02 ALB FLCN FNIP1 IL1B TNF

Drugs & Therapeutics for Pleural Disease

Drugs for Pleural Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 313)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
3
Lymecycline Approved Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
5
Cefazolin Approved Phase 4,Phase 2,Phase 3 25953-19-9 656510 33255
6
Clindamycin Approved, Vet_approved Phase 4,Phase 2,Phase 3 18323-44-9 29029
7
Zoledronic acid Approved Phase 4,Phase 2 118072-93-8 68740
8
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
9
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
10
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
11
Reteplase Approved Phase 4 133652-38-7 65820
12
Tenecteplase Approved Phase 4,Phase 2,Phase 3 191588-94-0
13
Ketotifen Approved Phase 4 34580-14-8, 34580-13-7 3827
14
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
15
Ofloxacin Approved Phase 4 82419-36-1 4583
16
Povidone Approved Phase 4,Phase 3 9003-39-8
17 Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
18
Mesna Approved Phase 4 3375-50-6 598
19
Streptokinase Approved Phase 4 9002-01-1
20
Iodine Investigational Phase 4,Phase 3,Phase 1 7553-56-2 807
21 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
22 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
23 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
24 Antitubercular Agents Phase 4,Phase 2,Phase 3
25 Antimalarials Phase 4,Phase 3,Phase 2
26 Antiparasitic Agents Phase 4,Phase 3,Phase 2
27 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
28 Pulmonary Surfactants Phase 4,Phase 3
29 Respiratory System Agents Phase 4,Phase 3,Phase 1
30 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Plasminogen Phase 4,Phase 3,Phase 2,Phase 1
32 Tissue Plasminogen Activator Phase 4,Phase 3,Phase 2,Phase 1
33 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
34 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
35 Anti-Inflammatory Agents Phase 4,Phase 2
36 Antineoplastic Agents, Hormonal Phase 4,Phase 2
37 Autonomic Agents Phase 4,Phase 3,Phase 2
38 Gastrointestinal Agents Phase 4,Phase 2
39 glucocorticoids Phase 4,Phase 2
40 Hormone Antagonists Phase 4,Phase 2
41 Hormones Phase 4,Phase 2
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
43 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
44 Topoisomerase Inhibitors Phase 4,Phase 3
45 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2
46 Micronutrients Phase 4,Phase 2,Phase 1
47 Trace Elements Phase 4,Phase 2,Phase 1
48 Clindamycin palmitate Phase 4,Phase 2,Phase 3
49 Clindamycin phosphate Phase 4,Phase 2,Phase 3
50 Bone Density Conservation Agents Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 385)

id Name Status NCT ID Phase Drugs
1 Improving Primary Spontaneous Pneumothorax (PSP) Treatment Techniques in VATS Unknown status NCT01463553 Phase 4
2 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Unknown status NCT00313066 Phase 4
3 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
4 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
5 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
6 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
7 Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema Completed NCT01246453 Phase 4 Intrapleurally Alteplase vs Intrapleurally Urokinase
8 Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter Completed NCT00978939 Phase 4
9 Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion Completed NCT01670786 Phase 4
10 Talc Pleurodesis in Patients With Recurrent Malignant Pleural Effusion Completed NCT00789087 Phase 4
11 Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy Completed NCT02446782 Phase 4 Cefazolin
12 Non-small Cell Lung Cancer Registry Completed NCT00099541 Phase 4 zoledronic acid
13 Comparison of the Ultra-low-dose Veo Algorithm With the Gold Standard Filtered Back Projection for Detecting Pulmonary Asbestos-related Conditions Completed NCT01955018 Phase 4
14 PleuraSeal Post Market Study (Europe) Completed NCT00704171 Phase 4
15 Fibrinolytic Therapy Versus Medical Thoracoscopy Recruiting NCT03213834 Phase 4 tPA;DNase
16 Early Intrapleural TPA Instillation Versus Late Recruiting NCT03167281 Phase 4
17 Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Recruiting NCT02673840 Phase 4 Ketotifen;Placebo
18 Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia Recruiting NCT02618057 Phase 4 Prednisolone;Levofloxacin
19 The Effect of Chest Tubes Using Active Clearance Technology® on the Incidence of Postoperative Atrial Fibrillation Recruiting NCT02808897 Phase 4
20 Epidemiology and Outcome of Solitary Fibrous Tumors of the Pleura. Active, not recruiting NCT01694654 Phase 4
21 Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital Not yet recruiting NCT03172052 Phase 4 streptokinase;MESNA (2-mercaptoethane sulfonate Na)
22 Betadine Pleurodesis Via Tunneled Pleural Catheters Not yet recruiting NCT02975921 Phase 4 Povidone-Iodine
23 Safety, Efficacy, and Side Effects Study of Interventional Cryotherapy in the Pleural Space("ICE PLS") Terminated NCT00747916 Phase 4
24 Pleural Abrasion Plus Minocycline Versus Apical Pleurectomy for Primary Spontaneous Pneumothorax Unknown status NCT00270751 Phase 2, Phase 3
25 Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax Unknown status NCT00418392 Phase 3
26 Pigtail Catheter Versus Chest Tube in the Management of Traumatic Pneumothorax Unknown status NCT01537289 Phase 3
27 Chest Tube Drainage or Thoracoscopic Surgery for Failed Aspiration of Spontaneous Pneumothorax Unknown status NCT00713362 Phase 2, Phase 3
28 Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax Unknown status NCT00154895 Phase 3 intrapleural minocycline instillation
29 Comparing 14 F Pigtail Catheter to Traditional 28-32F Chest Tube in the Management of Traumatic Hemothorax and Hemopneumothorax Unknown status NCT02553434 Phase 3
30 Intrapleural Urokinase for Retained Hemothorax Unknown status NCT01134237 Phase 3 urokinase;placebo
31 Comparison of Intrapleural Urokinase and Video-Assisted Thorascopic Surgery in the Treatment of Parapneumonic Pleural Effusion in Children Unknown status NCT02165891 Phase 3 insertion of a chest drain with urokinase instillation
32 Dornase Alfa and Urokinase for Kids With Pleural Empyema Unknown status NCT00502632 Phase 2, Phase 3 Urokinase and Dornase alfa;Urokinase
33 COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial) Unknown status NCT01552187 Phase 3 Colchicine;Placebo
34 Chest Tube After a Video-assisted Thoracoscopic Surgery Pulmonary Wedge Resection Unknown status NCT00841750 Phase 3
35 NGR015: Study in Second Line for Patient With Advanced Malignant Pleural Mesothelioma Pretreated With Pemetrexed Unknown status NCT01098266 Phase 3 NGR-hTNF plus Best Investigator's Choice (BIC);Placebo plus Best Investigator's Choice (BIC)
36 Efficacy and Safety of Sirolimus for Treating Lymphangioleiomyomatosis (LAM) Unknown status NCT00414648 Phase 3 Sirolimus;Placebo sirolimus
37 ONCONASE Plus Doxorubicin Versus Doxorubicin Alone For Patients With Malignant Pleural or Peritoneal Mesothelioma Who Have Had No More Than One Prior Chemotherapy Regimen Unknown status NCT00003034 Phase 3 doxorubicin hydrochloride;ranpirnase
38 Rigid Versus Semirigid Thoracoscopy in Diagnosing Pleural Diseases: a Randomized Study Completed NCT01366261 Phase 3
39 Cryobiopsy or Forceps Biopsy During Semirigid Thoracoscopy: a Comparative Study Completed NCT01475084 Phase 2, Phase 3
40 Efficacy of the Additional Mechanical Pleurodesis for Surgical Management of Primary Spontaneous Pneumothorax Completed NCT00615849 Phase 3
41 Bio-Seal Biopsy Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Procedure Completed NCT00562302 Phase 3
42 Role of Antibiotics to Reduce Infectious Complications in Tube Thoracotomy Management of Traumatic Hemopneumothorax Completed NCT01127880 Phase 2, Phase 3 Ancef or Clindamycin;Placebo
43 Very Early Surfactant and NCPAP for Premature Infants With RDS Completed NCT00563641 Phase 3
44 A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions Completed NCT00758316 Phase 3
45 Efficacy and Safety Study of Abnoba Viscum F 20mg in Malignant Pleural Effusion Patients Completed NCT02191540 Phase 3 Abnoba Viscum F 20mg
46 KatGuide Method Versus Conventional Method at Insertion of Chest Tube Completed NCT01522885 Phase 3
47 Gene Expression Profiling of Breast Cancer Cells Predict the Response of Malignant Pleural Effusion Completed NCT01256801 Phase 3
48 Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer Completed NCT00042770 Phase 3
49 Talc in Treating Patients With Malignant Pleural Effusion Completed NCT00002622 Phase 3 talc;Talc
50 Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions Completed NCT00002872 Phase 3 doxycycline

Search NIH Clinical Center for Pleural Disease

Cochrane evidence based reviews: pleural diseases

Genetic Tests for Pleural Disease

Genetic tests related to Pleural Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Pleura 29

Anatomical Context for Pleural Disease

MalaCards organs/tissues related to Pleural Disease:

39
Lung, Heart, Testes, T Cells, Myeloid, Endothelial, Bone

Publications for Pleural Disease

Articles related to Pleural Disease:

(show top 50) (show all 59)
id Title Authors Year
1
Tuberculous pleural effusion occurring concurrently with asbestos-related pleural disease. ( 28491491 )
2017
2
State-of-the-art: Radiological investigation of pleural disease. ( 28233652 )
2017
3
The Effect of Benign and Malignant Pleural Disease on Chest Wall Mechanics. ( 28707974 )
2017
4
Medical Thoracoscopy in Pleural Disease: Experience from a One-Center Study. ( 28416960 )
2017
5
Safety and Performance Characteristics of Outpatient Medical Thoracoscopy and Indwelling Pleural Catheter Insertion for Evaluation and Diagnosis of Pleural Disease at a Tertiary Center in Canada. ( 28951662 )
2017
6
Chest ultrasonography in health surveillance of asbestos related pleural disease. ( 28838385 )
2017
7
Ultrasound in the management of pleural disease. ( 28345480 )
2017
8
Primary Malignant Lymphoma Originating from the Chest Wall without Preceding Pleural Disease. ( 28321070 )
2017
9
Migrating pleural plaque in a patient with asbestos induced pleural disease: a case report. ( 28855951 )
2017
10
The importance of units specialising in pleural disease for postgraduate training. ( 27908379 )
2016
11
Advances in pleural disease. ( 27246586 )
2016
12
Diagnostic Utility of Pleural Fluid Cell Block versus Pleural Biopsy Collected by Flex-Rigid Pleuroscopy for Malignant Pleural Disease: A Single Center Retrospective Analysis. ( 27880851 )
2016
13
25-hydroxyvitamin D in malignant pleural disease: a prospective cohort study. ( 27502152 )
2016
14
Rapid on-site evaluation with the Hemacolor rapid staining method of medical thoracoscopy biopsy specimens for the management of pleural disease. ( 27080382 )
2016
15
Reduced Port Thoracoscopic Surgery for Mediastinal and Pleural Disease: Experiences in a Single Institution. ( 27358509 )
2016
16
"Advanced medical interventions in pleural disease." Rahul Bhatnagar, John P. Corcoran, Fabien Maldonado, David Feller-Kopman, Julius Janssen, Philippe Astoul and Najib M. Rahman. Eur Respir Rev 2016; 25: 199-213. ( 27581835 )
2016
17
Should primary tumor be resected for non-small cell lung cancer with malignant pleural disease unexpectedly found during operation?-a systemic review and meta-analysis. ( 27867560 )
2016
18
IgG4-related disease in asbestos-related pleural disease. ( 26839697 )
2016
19
Ultrasound-Guided Abrams Pleural Biopsy vs CT-Guided Tru-Cut Pleural Biopsy in Malignant Pleural Disease, a 3-Year Follow-up Study. ( 27540734 )
2016
20
Role of respiratory-triggered diffusion-weighted MRI in the assessment of pleural disease. ( 27302493 )
2016
21
Malignant pleural disease is highly associated with subsequent peritoneal metastasis in patients with stage IV non-small cell lung cancer independent of oncogene status. ( 27133746 )
2016
22
Advanced medical interventions in pleural disease. ( 27246597 )
2016
23
Erratum: Multidetector CT Findings and Differential Diagnoses of Malignant Pleural Mesothelioma and Metastatic Pleural Diseases in Korea. ( 27587973 )
2016
24
Physical activity in people with asbestos related pleural disease and dust-related interstitial lung disease: An observational study. ( 26048393 )
2015
25
The impact of pleural disease on the management of advanced ovarian cancer. ( 25969350 )
2015
26
A modified experimental model of malignant pleural disease induced by lung Lewis carcinoma (LLC) cells. ( 26373420 )
2015
27
A pilot study of autofluorescence in the diagnosis of pleural disease. ( 25411951 )
2015
28
The past, current and future of diagnosis and management of pleural disease. ( 26807281 )
2015
29
Accidental discovery of asbestos-related occupational pleural disease in unemployed carpenter: a healthcare safety net that needs mending. ( 26444343 )
2015
30
A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: a proof of principle pilot study. ( 25781025 )
2015
31
Autofluorescence thoracoscopy in pleural disease: does it have clinical relevance? ( 24856077 )
2014
32
Physician-based ultrasound-guided biopsy for diagnosing pleural disease. ( 24832701 )
2014
33
Advances in pleural disease management including updated procedural coding. ( 25091756 )
2014
34
Mediastinectomy for management of chronic pyogranulomatous pleural disease in dogs. ( 24686857 )
2014
35
IgG4-related pleural disease presenting as a massive bilateral effusion. ( 24992134 )
2014
36
Rapid progression of pleural disease due to exposure to Libby amphibole: "Not your grandfather's asbestos related disease". ( 24898907 )
2014
37
A rare cause of pleural disease. ( 23487832 )
2013
38
Progress means change: reflections on two articles about pleural disease. ( 23720696 )
2013
39
Advances in the management of pleural disease. ( 24138694 )
2013
40
Levels of YKL-40 in pleural effusions and blood from patients with pulmonary or pleural disease. ( 22480951 )
2012
41
Management of spontaneous pneumothorax: British Thoracic Society Pleural Disease Guideline 2010. ( 20696690 )
2010
42
Crystal-storing histiocytosis presenting with pleural disease. ( 20459543 )
2010
43
Clinical value of fluorodeoxyglucose-positron emission tomography/computed tomography in differentiation of malignant mesothelioma from asbestos-related benign pleural disease: an observational pilot study. ( 19875971 )
2009
44
Managing Pleural Disease in Acute Medicine ( II ) : Spontaneous Pneumothorax. ( 21611569 )
2008
45
Pleural disease in lymphangioleiomyomatosis. ( 16716823 )
2006
46
Clinical year in review II: pulmonary infections, diagnostic imaging, pleural diseases, and neuromuscular disease. ( 16222034 )
2005
47
Resolution of residual pleural disease according to time course in tuberculous pleurisy during and after the termination of antituberculosis medication. ( 16304268 )
2005
48
The additional risk of malignant mesothelioma in former workers and residents of Wittenoom with benign pleural disease or asbestosis. ( 16169910 )
2005
49
Pleural disease in silicosis: pleural thickening, effusion, and invagination. ( 16040925 )
2005
50
Lymphocytes in pleural disease. ( 15928502 )
2005

Variations for Pleural Disease

Expression for Pleural Disease

Search GEO for disease gene expression data for Pleural Disease.

Pathways for Pleural Disease

Pathways related to Pleural Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 12.12 ALOX5 IL1B MPO TNF
2
Show member pathways
12.03 FLCN FNIP1 FNIP2 TNF
3 11.6 ALOX5 IL1B TNF
4 11.01 KNG1 MPO TNF
5 10.81 IL1B KLKB1 TNF
6 10 IL1B MPO TNF

GO Terms for Pleural Disease

Cellular components related to Pleural Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ALB ALOX5 CHI3L1 CRP CXCL13 IL1B
2 extracellular space GO:0005615 9.36 ADA ALB ALOX5 CHI3L1 CRP CXCL13

Biological processes related to Pleural Disease according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.71 FLCN FNIP1 IL1B TNF
2 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.69 FNIP1 FNIP2 TNF
3 blood coagulation, intrinsic pathway GO:0007597 9.59 KLKB1 KNG1
4 embryonic digestive tract development GO:0048566 9.58 ADA TNF
5 negative regulation of lipid catabolic process GO:0050995 9.58 IL1B TNF
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 IL1B TNF
7 negative regulation of growth of symbiont in host GO:0044130 9.56 MPO TNF
8 TOR signaling GO:0031929 9.55 FLCN FNIP1
9 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.54 IL1B TNF
10 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.52 IL1B TNF
11 positive regulation of chemokine biosynthetic process GO:0045080 9.49 IL1B TNF
12 negative regulation of lipid storage GO:0010888 9.48 CRP TNF
13 regulation of establishment of endothelial barrier GO:1903140 9.46 IL1B TNF
14 positive regulation of fever generation GO:0031622 9.43 IL1B TNF
15 sequestering of triglyceride GO:0030730 9.37 IL1B TNF
16 positive regulation of protein complex assembly GO:0031334 9.33 FNIP1 FNIP2 TNF
17 regulation of pro-B cell differentiation GO:2000973 9.32 FLCN FNIP1
18 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
19 regulation of protein phosphorylation GO:0001932 9.26 FLCN FNIP1 FNIP2 TNF
20 inflammatory response GO:0006954 9.23 ALOX5 CHI3L1 CRP CXCL13 IL1B KLKB1

Molecular functions related to Pleural Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 9.13 ALB FNIP1 FNIP2
2 ATPase inhibitor activity GO:0042030 8.62 FNIP1 FNIP2

Sources for Pleural Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....