MCID: PLR007
MIFTS: 42

Pleural Empyema

Categories: Respiratory diseases, Rare diseases

Aliases & Classifications for Pleural Empyema

MalaCards integrated aliases for Pleural Empyema:

Name: Pleural Empyema 12 56 14
Empyema 12 52 69
Empyema, Pleural 42 69
Empyema Without Mention of Fistula 12
Empyema of Pleura Without Fistula 12
Pleural Empyema with No Fistula 12
Empyema with Pleural Fistula 12
Pleural Empyema with Fistula 12
Abscess of Pleural Cavity 12
Empyema with No Fistula 12
Empyema with Fistula 12
Purulent Pleuritis 12
Abscess of Thorax 12
Empyema of Pleura 12
Purulent Pleurisy 12
Empyema, Chest 12
Thorax Abscess 12
Lung Empyema 12
Pyothorax 12

Characteristics:

Orphanet epidemiological data:

56
pleural empyema
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 56  
Rare respiratory diseases


Summaries for Pleural Empyema

Disease Ontology : 12 A soft tissue infectious disease that involves accumulation of pus in the pleural cavity as a result of infection within the lung (pneumonia) or a lung abscess spreading into the space. The symptoms include cough, fever, chest pain, sweating and shortness of breath.

MalaCards based summary : Pleural Empyema, also known as empyema, is related to subdural empyema and tuberculous empyema. An important gene associated with Pleural Empyema is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Aurora B signaling and Cell cycle_Chromosome condensation in prometaphase. The drugs Cefazolin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and testes.

Wikipedia : 72 Pleural empyema is a collection of pus in the pleural cavity caused by microorganisms, usually bacteria.... more...

Related Diseases for Pleural Empyema

Diseases related to Pleural Empyema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Related Disease Score Top Affiliating Genes
1 subdural empyema 12.3
2 tuberculous empyema 11.0
3 urethral gland abscess 10.5 ADA CRP
4 inhalation anthrax 10.4 CRP P3H2
5 polyarteritis nodosa 10.4 ADA CRP
6 orbital tenonitis 10.4 CRP PGBD1
7 appendix lymphoma 10.4 CRP PGBD1
8 glycogen storage disease viii 10.4 CRP P3H2
9 signet ring cell adenocarcinoma 10.4 CRP P3H2
10 functional gastric disease 10.4 ADA CRP
11 herpetic whitlow 10.4 HSF4 P3H2
12 heart disease 10.3 CRP PGBD1
13 retinal cancer 10.3 HSF4 P3H2
14 arthus reaction 10.3 ADA CRP
15 inguinal hernia 10.3 CRP HSF4
16 shigellosis 10.3 HSF4 P3H2
17 axillary adenitis 10.3 CRP HSF4
18 pneumoconiosis 10.3 ADA CRP
19 hypertensive heart disease 10.2 CRP HSF4
20 louping ill 10.2 ADA CRP
21 opportunistic bacterial infectious disease 10.2 ADA CRP
22 pleurisy 10.1
23 urinary bladder posterior wall cancer 10.1 ADA CRP
24 pneumonia 10.1
25 lung abscess 9.9
26 mediastinitis 9.9
27 pancreas lymphoma 9.9 ADA CRP
28 esophagitis 9.9
29 pneumothorax 9.9
30 bacteremia 9.8
31 acne 9.8
32 liver cirrhosis 9.8
33 pericarditis 9.8
34 aortic aneurysm 9.8
35 aneurysm 9.8
36 lung cancer 9.6
37 hodgkin lymphoma 9.6
38 myelodysplastic syndrome 9.6
39 cystic fibrosis 9.6
40 pleuropulmonary blastoma 9.6
41 sleep apnea 9.6
42 obstructive sleep apnea 9.6
43 lymphoma 9.6
44 blastoma 9.6
45 endobronchial lipoma 9.6
46 osteomyelitis 9.6
47 disseminated intravascular coagulation 9.6
48 epidural abscess 9.6
49 pulmonary edema 9.6
50 diarrhea 9.6

Graphical network of the top 20 diseases related to Pleural Empyema:



Diseases related to Pleural Empyema

Symptoms & Phenotypes for Pleural Empyema

Drugs & Therapeutics for Pleural Empyema

Drugs for Pleural Empyema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefazolin Approved Phase 4 25953-19-9 656510 33255
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3 Fibrinolytic Agents Phase 4,Phase 3
4 Plasminogen Phase 4,Phase 3
5 Tissue Plasminogen Activator Phase 4,Phase 3
6 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
7 Antibiotics, Antitubercular Phase 4
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2
9 Antitubercular Agents Phase 4
10 Clindamycin palmitate Phase 4
11 Clindamycin phosphate Phase 4
12
Meropenem Approved, Investigational Phase 3 119478-56-7 64778 441130
13
Piperacillin Approved Phase 3 66258-76-2 43672
14
Tazobactam Approved Phase 3 89786-04-9 123630
15 beta-Lactamase Inhibitors Phase 3,Phase 2
16 Penicillanic Acid Phase 3
17 Piperacillin, tazobactam drug combination Phase 3
18 Thienamycins Phase 3
19
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613 2171
20
Cefotaxime Approved Phase 2 63527-52-6 456256 5742673
21
Cefoxitin Approved Phase 2 35607-66-0 441199
22
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
23
Histamine Approved, Investigational Phase 2 75614-87-8, 51-45-6 774
24
Ranitidine Approved Phase 2 66357-59-3, 66357-35-5 3001055
25 Amoxicillin-Potassium Clavulanate Combination Phase 2
26 Antacids Phase 2
27 Antiemetics Phase 2
28 Anti-Inflammatory Agents Phase 2
29 Antineoplastic Agents, Hormonal Phase 2
30 Anti-Ulcer Agents Phase 2
31 Autonomic Agents Phase 2
32 BB 1101 Phase 2
33
Bismuth Phase 2 7440-69-9 16682734 105143
34 Bismuth tripotassium dicitrate Phase 2
35 Clavulanic Acid Phase 2
36 Dexamethasone acetate Phase 2 1177-87-3
37 Gastrointestinal Agents Phase 2
38 glucocorticoids Phase 2
39 Histamine Antagonists Phase 2
40 Histamine H2 Antagonists Phase 2
41
Histamine Phosphate Phase 2 51-74-1 65513
42 HIV Protease Inhibitors Phase 2
43 Hormone Antagonists Phase 2
44 Hormones Phase 2
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
46 Neurotransmitter Agents Phase 2
47 Peripheral Nervous System Agents Phase 2
48
protease inhibitors Phase 2
49 Ranitidine bismuth citrate Phase 2
50 Citrate Nutraceutical Phase 2

Interventional clinical trials:

(show all 18)

id Name Status NCT ID Phase Drugs
1 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Unknown status NCT00313066 Phase 4
2 Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema Completed NCT01246453 Phase 4 Intrapleurally Alteplase vs Intrapleurally Urokinase
3 Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy Completed NCT02446782 Phase 4 Cefazolin
4 Fibrinolytic Therapy Versus Medical Thoracoscopy Recruiting NCT03213834 Phase 4 tPA;DNase
5 Dornase Alfa and Urokinase for Kids With Pleural Empyema Unknown status NCT00502632 Phase 2, Phase 3 Urokinase and Dornase alfa;Urokinase
6 Comparison of Intrapleural Urokinase and Video-Assisted Thorascopic Surgery in the Treatment of Parapneumonic Pleural Effusion in Children Unknown status NCT02165891 Phase 3 insertion of a chest drain with urokinase instillation
7 Thoracoscopy Versus Fibrinolysis in Children With Empyema Completed NCT00323531 Phase 2, Phase 3
8 Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial) Recruiting NCT01717742 Phase 3 tPA;DNase
9 A Study of Meropenem-Vaborbactam Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia Not yet recruiting NCT03006679 Phase 3 Meropenem-Vaborbactam;Piperacillin/Tazobactam
10 Early Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusion and Pleural Empyema Terminated NCT00234208 Phase 3
11 Clinical Trial Corticoids For Empyema And Pleural Effusion In Children Completed NCT01261546 Phase 2 Dexamethasone;Placebo
12 Alteplase for Treatment of Empyema and Complicated Parapneumonic Effusion Unknown status NCT00103766 Alteplase
13 Procalcitonin in Pleural Pleuritis Completed NCT01011881
14 Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/Empyemas Completed NCT00468104 Alteplase;Placebo
15 Procoagulant Activity in Patients With Community Acquired Pneumonia, Pleural Effusion and Empyema Completed NCT01178580
16 The Fast Track Rehabilitation in Thoracic Surgery Recruiting NCT02831140
17 Fibrinolysis Compared to Thoracoscopy for Pleural Infection Recruiting NCT02973139
18 Randomized Study Comparing Pleural Drainage by Videothoracoscopy to Medical Drainage in Infectious Pleural Effusion Recruiting NCT01994499 Medical drainage

Search NIH Clinical Center for Pleural Empyema

Cochrane evidence based reviews: empyema, pleural

Genetic Tests for Pleural Empyema

Anatomical Context for Pleural Empyema

MalaCards organs/tissues related to Pleural Empyema:

39
Lung, Liver, Testes, Spinal Cord

Publications for Pleural Empyema

Articles related to Pleural Empyema:

(show top 50) (show all 272)
id Title Authors Year
1
Uniportal thoracoscopic decortication for pleural empyema and the role of ultrasonographic preoperative staging. ( 28108575 )
2017
2
Preoperative predictors of conversion in thoracoscopic surgery for pleural empyema. ( 28369294 )
2017
3
Management of Aspergillus pleural empyema with combined systemic and intrapleural antifungal therapy in a pediatric patient: Case report. ( 28545901 )
2017
4
Pediatric pleural empyema: one of the management challenges in children of Democratic Republic of Congo. ( 28673074 )
2017
5
Population-based cohort study investigating the correlation of diabetes mellitus with pleural empyema in adults in Taiwan. ( 28885331 )
2017
6
Propionibacterium acnes pleural empyema following medical thoracoscopy. ( 28638619 )
2017
7
Risk of developing pleural empyema in patients with stroke: a propensity-matched cohort study. ( 28698956 )
2017
8
Pneumonia with pleural empyema caused by Salmonella Typhi in an immunocompetent child living in a non-endemic country. ( 28436267 )
2017
9
Pleural empyema caused by incarceration and perforation of the stomach wall discovered several years later after thoracic trauma. ( 28747950 )
2017
10
A Simplified Technique for Drainage of Chronic Calcified Pleural Empyema. ( 28131104 )
2017
11
Pleural empyema and streptococcal toxic shock syndrome due to Streptococcus pyogenes in a healthy Spanish traveler in Japan. ( 28725562 )
2017
12
Surgical versus non-surgical management for pleural empyema. ( 28304084 )
2017
13
An Approach to the Management of Pleural Empyema with Early Video-assisted Thoracoscopic Surgery and Early Transition to Oral Antibiotic Therapy. ( 27097620 )
2016
14
Intrapleural urokinase therapy in a neonate with pleural empyema. ( 27460398 )
2016
15
Stage-directed therapy of pleural empyema. ( 27815709 )
2016
16
Pleural empyema due to Salmonella enterica serovar Enteritidis in an immunocompetent elderly patient: a case report. ( 28348773 )
2016
17
Pleural Empyema Following Liver Resection: A Rare But Serious Complication. ( 27464918 )
2016
18
Video-assisted thoracoscopic decortication for the management of late stage pleural empyema, is it feasible? ( 26933461 )
2016
19
P1.31: Pleural Empyema and Broncho Pleural Fistula After Lung Resection: Analyses of 29 Patients Treated in our Clinic: Track: Advanced NSCLC. ( 27676517 )
2016
20
Etiology of parapneumonic effusion and pleural empyema in children. The role of conventional and molecular microbiological tests. ( 27296817 )
2016
21
Clinical characteristics of 323 children with parapneumonic pleural effusion and pleural empyema due to community acquired pneumonia. ( 26919911 )
2016
22
Double jeopardy - concurrent lung abscess and pleural empyema. ( 27208219 )
2016
23
Diffuse descending necrotising mediastinitis and pleural empyema secondary to acute odontogenic infection resulting in severe dysphagia. ( 27013653 )
2016
24
Pleural empyema caused by Salmonella enteritidis in a patient with non-Hodgkin lymphoma. ( 27295915 )
2016
25
Is open decortication superior to fibrinolytic therapy as a first line treatment in the management of pleural empyema? ( 27182233 )
2016
26
Pleural empyema: a case of failing to see the discharge leading to discharge failure. ( 27899685 )
2016
27
Pneumonia and Pleural Empyema due to a Mixed Lactobacillus spp. Infection as a Possible Early Esophageal Carcinoma Signature. ( 27734016 )
2016
28
Incidence, aetiology and outcome of pleural empyema and parapneumonic effusion from 1998 to 2012 in a population of New Zealand children. ( 27059295 )
2016
29
Pleural empyema in a pneumonectomized patient as a complication of colonoscopy. ( 26422184 )
2015
30
Efficacy of intrapleural instillation of fibrinolytics for treating pleural empyema and parapneumonic effusion: appropriateness of including paediatric trials in meta-analysis. ( 25707421 )
2015
31
Intrapleural administration of DNase alone for pleural empyema. ( 26885174 )
2015
32
Mini-open vacuum-assisted closure therapy with instillation for debilitated and septic patients with pleural empyema. ( 26017017 )
2015
33
Pleural empyema caused by Klebsiella oxytoca: A case series. ( 25677866 )
2015
34
EACTS expert consensus statement for surgical management of pleural empyema. ( 26254467 )
2015
35
Pleural Empyema and Aortic Aneurysm: A Retrospective National Population-Based Cohort Study. ( 26632741 )
2015
36
Photo Quiz: Mysterious Objects in a Pleural Biopsy Sample from a Patient with Recurrent Pleural Empyema. ( 26089383 )
2015
37
Etiology and Incidence of Pleural Empyema in South African Children. ( 26267310 )
2015
38
Incidence, length of stay, and prognosis of hospitalized patients with pleural empyema: a 15-year danish nationwide cohort study. ( 24394842 )
2014
39
Surgery for parapneumonic pleural empyema - What influence does the rising prevalence of multimorbidity and advanced age has on the current outcome? ( 24930000 )
2014
40
Pediatric Pleural Empyema in the Province of Quebec: Analysis of a 10-Fold Increase Between 1990 and 2007. ( 26625364 )
2014
41
Minimally Invasive Vacuum-Assisted Closure Therapy With Instillation (Mini-VAC-Instill) for Pleural Empyema. ( 25049317 )
2014
42
Experimental pleural empyema model in rabbits: Why, how and what are the next steps. ( 26137715 )
2014
43
Hiding behind confusion: pleural empyema caused by Parvimonas micra. ( 24796229 )
2014
44
Repair of Bochdalek hernia in an adult complicated by abdominal compartment syndrome, gastropleural fistula and pleural empyema: Report of a case. ( 24441713 )
2014
45
Risk factors for the development of pleural empyema in children. ( 24692118 )
2014
46
Liver abscess complicated by diaphragm perforation and pleural empyema leads to the discovery of interleukin-1 receptor-associated kinase 4 deficiency. ( 24717963 )
2014
47
The treatment of chronic pleural empyema with laparoscopic omentoplasty. Initial report. ( 25561992 )
2014
48
Serotype 3 pneumococcal pleural empyema in an immunocompetent child after 13-valent pneumococcal conjugate vaccine. ( 24732391 )
2014
49
New tetratrichomonas species in two patients with pleural empyema. ( 23784131 )
2013
50
Management of pleural empyema: don't miss the point! ( 23988456 )
2013

Variations for Pleural Empyema

Expression for Pleural Empyema

Search GEO for disease gene expression data for Pleural Empyema.

Pathways for Pleural Empyema

Pathways related to Pleural Empyema according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.61 SMC2 SMC4
2 10.14 SMC2 SMC4

GO Terms for Pleural Empyema

Cellular components related to Pleural Empyema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 condensin complex GO:0000796 8.62 SMC2 SMC4

Biological processes related to Pleural Empyema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chromosome organization GO:0051276 9.37 SMC2 SMC4
2 chromosome condensation GO:0030261 9.32 SMC2 SMC4
3 mitotic chromosome condensation GO:0007076 9.26 SMC2 SMC4
4 meiotic chromosome segregation GO:0045132 9.16 SMC2 SMC4
5 meiotic chromosome condensation GO:0010032 8.96 SMC2 SMC4
6 kinetochore organization GO:0051383 8.62 SMC2 SMC4

Sources for Pleural Empyema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....