MCID: PLR008
MIFTS: 53

Pleurisy malady

Summaries for Pleurisy

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. the inflamed pleural layers rub against each other every time the lungs expand to breathe in air. this can cause sharp pain with breathing (also called pleuritic chest pain).

MalaCards: Pleurisy is related to tuberculosis and pleural tuberculosis. An important gene associated with Pleurisy is ADA (adenosine deaminase), and among its related pathways are Malaria and Rheumatoid arthritis. The compounds gm-csf and pge2 have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Wikipedia:63 Pleurisy (also known as pleuritis) is an inflammation of the pleura, the lining surrounding the lungs.... more...

Aliases & Classifications for Pleurisy

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 25ICD10
See all sources

Related Diseases for Pleurisy

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pleurisy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 216)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.8CCL3, IFNG, CXCL9, IL2RA, IL18, CEACAM7
2pleural tuberculosis30.6ADA, CEACAM7, IL8, IL18, IL2RA, PSG2
3pneumonia30.4PSG2, PDE4A, CCL3, CCL2, IL8, PLA2G7
4sarcoidosis30.3CCL2, CCL3, IFNG, TRB, CXCL9, IL2RA
5lupus erythematosus30.2IL18
6systemic lupus erythematosus30.2CCL2, CCL3, IFNG, TRB, IL2RA, IL18
7arthritis30.2CCL2, CCL3, IFNG, MEFV, TRB, CXCL9
8rheumatoid arthritis30.2CCL2, CCL3, ADA, ALOX5, PLA2G1B, PLA2G6
9malignant mesothelioma30.1MUC16
10leukemia30.1CCL3, IFNG, PSG2, TRB, IL2RA, PLA2G6
11breast cancer30.1ADA, CEACAM7, MUC16, PSG2, CCL3
12pulmonary tuberculosis30.0CCL3, IFNG, MUC16, IL2RA, IL18, ADA
13peritonitis30.0CCL2, ADA, ALOX5, PLA2G6, MUC16, MEFV
14familial mediterranean fever29.8MEFV
15sarcoma29.8ADA
16hepatitis29.8IL18
17dermatomyositis29.8CCL3, MUC16
18synovitis29.8IL8, IL18
19interstitial lung disease29.8CCL2, CCL3, IL8
20mastitis29.8IL8
21chronic lymphocytic leukemia29.8ADA, IL2RA, TRB, PDE4A
22eosinophilia29.8IFNG, PDE4A, IL2RA, IL18, IL8, ALOX5
23encephalomyelitis29.8CCL2, CCL3, IFNG, PDE4A, TRB, ALOX5
24pulmonary sarcoidosis29.8IL18, IL2RA, CXCL9, TRB, IFNG, CCL3
25ulcerative colitis29.8IFNG, PDE4A, IL2RA, IL18, IL8, PLA2G7
26lung cancer10.4
27pertussis10.3
28pleural cancer10.2
29tuberculous pneumothorax10.0
30pneumothorax10.0
31acute myocardial infarction10.0MEFV
32rhinitis10.0IL8
33extrapulmonary tuberculosis10.0ADA
34liver cirrhosis10.0ADA
35multiple myeloma10.0CCL3
36urticaria10.0ALOX5
37alopecia areata10.0IFNG
38leishmaniasis10.0IFNG
39human immunodeficiency virus infectious disease10.0CCL3
40bladder carcinoma10.0PSG2
41hypercholesterolemia10.0PLA2G7
42keratitis10.0CXCL9
43polymyositis10.0CCL3
44vascular disease10.0IL8
45myasthenia gravis10.0IFNG
46nephrotic syndrome10.0IL2RA, PLA2G7
47brucellosis10.0MEFV
48arthropathy10.0ALOX5
49myeloid leukemia10.0TRB
50deficiency anemia10.0MUC16

Graphical network of the top 20 diseases related to Pleurisy:



Diseases related to pleurisy

Clinical Features for Pleurisy

About this section

Drugs & Therapeutics for Pleurisy

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pleurisy

Drug clinical trials:

Search ClinicalTrials for Pleurisy

Search NIH Clinical Center for Pleurisy

Search CenterWatch for Pleurisy

Genetic Tests for Pleurisy

About this section

Anatomical Context for Pleurisy

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Pleurisy:

32
Lung, T cells, Testes, Nk cells, Breast, Monocytes, Skin

Animal Models for Pleurisy or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pleurisy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.9ADA, PLA2G1B, TRB, MEFV, IFNG, CCL2
2MP:00053979.5CCL2, CCL3, IFNG, MEFV, TRB, IL2RA
3MP:00053819.5CCL2, CCL3, IFNG, TRB, IL2RA, IL18
4MP:00053849.4PHLDA2, IFNG, CCL3, CCL2, MEFV, TRB
5MP:00053879.3ADA, CCL2, CCL3, IFNG, PDE4A, MEFV
6MP:00053789.3PHLDA2, IFNG, CCL3, CCL2, MEFV, TRB

Publications for Pleurisy

About this section
Sources:
50PubMed
See all sources

Articles related to Pleurisy:

(show top 50)    (show all 522)
idTitleAuthorsYear
1
Indoleamine 2,3-dioxygenase in the pathogenesis of tuberculous pleurisy. (24125458)
2013
2
PPAR-gamma agonist rosiglitazone attenuates the inflammation caused by carrageenan in the mouse model of pleurisy. (21465278)
2012
3
Proteinase-activated receptor-4 plays a major role in the recruitment of neutrophils induced by trypsin or carrageenan during pleurisy in mice. (22517275)
2012
4
Clinical Utility of Two Interferon-gamma Release Assays on Pleural Fluid for the Diagnosis of Tuberculous Pleurisy. (23166547)
2012
5
In-hospital outcome of patients with culture-confirmed tuberculous pleurisy: clinical impact of pulmonary involvement. (21338482)
2011
6
Identification of Mycobacterium tuberculosis-specific Th1, Th17 and Th22 cells using the expression of CD40L in tuberculous pleurisy. (21625607)
2011
7
Sonographic septation: a predictor of sequelae of tuberculous pleurisy after treatment. (19497923)
2009
8
Pleural fluid adenosine deaminase and interferon gamma as diagnostic tools in tuberculosis pleurisy. (19218659)
2008
9
Increased pleural soluble fas ligand (sFasL) levels in tuberculosis pleurisy and its relation with T-helper type 1 cytokines. (18663530)
2008
10
Pharmacokinetic study of pleural fluid penetration of carbapenem antibiotic agents in chemical pleurisy. (16493791)
2006
11
The diagnostic values of serum, pleural fluid and urine neopterin measurements in tuberculous pleurisy. (16158898)
2005
12
IgA antibody responses to Mycobacterium tuberculosis recombinant MPT-64 and MT-10.3 (Rv3019c) antigens in pleural fluid of patients with tuberculous pleurisy. (15830754)
2005
13
Effect of anti-inflammatory drugs on pleurisy induced by latex of Calotropis procera in rats. (15225678)
2004
14
Apoptotic changes in the myocardium in the course of experimentally-induced pleurisy. (15232782)
2004
15
Differential activation of NF kappa B/RelA-p50 and NF kappa B/p50-p50 in control and alcohol-drinking rats subjected to carrageenin-induced pleurisy. (15545056)
2004
16
Effect of Mycobacterium leprae lipids on BCG- and carrageenan-induced cellular recruitment in mouse pleurisy. (15527549)
2004
17
Evaluation of suspected tuberculous pleurisy: clinical and diagnostic findings in HIV-1-positive and HIV-negative adults in Uganda. (11495266)
2001
18
Participation of endogenous endothelins in delayed eosinophil and neutrophil recruitment in mouse pleurisy. (10858017)
2000
19
Stem cell factor plays a major role in the recruitment of eosinophils in allergic pleurisy in mice via the production of leukotriene B4. (10754325)
2000
20
Development of contralateral pleural effusion during chemotherapy for tuberculous pleurisy. (11500710)
2000
21
Extensive fibrinous pleurisy associated with Streptococcus dysgalactiae mastitis in two ewes. (10777043)
2000
22
Regulation of prostaglandin production in carrageenan-induced pleurisy by melatonin. (10451019)
1999
23
Migration of neutrophils is dependent on mast cells in nonspecific pleurisy in rats. (10549590)
1999
24
Tuberculous pleurisy with or without radiographic evidence of pulmonary disease. Is there any difference? (9626610)
1998
25
Effects of an orally active non-peptide bradykinin B2 receptor antagonist, FR173657, on plasma exudation in rat carrageenin-induced pleurisy. (9208140)
1997
26
Pro-inflammatory effects induced by bradykinin in a murine model of pleurisy. (9274929)
1997
27
Effects of inhibitors of inflammatory mediators and cytokines on eosinophil and neutrophil accumulation induced by Mycobacterium bovis bacillus Calmette-GuAcrin in mouse pleurisy. (9400819)
1997
28
Treatment of tuberculous pleurisy with effusion by artificial pneumothorax. (8758748)
1996
29
Progressive dyspnea, pleurisy, and hemoptysis of three weeks' duration in a 48-year-old woman. (8181352)
1994
30
Effect of treatment with interleukin-1 receptor antagonist on the development of carrageenan-induced pleurisy in the rat. (8491511)
1993
31
Interference of the PAF receptor antagonist, PCA 4248, with the rat pleurisy evoked by inflammatory mediators or allergen. (8395390)
1993
32
Adenosine deaminase in rheumatoid pleurisy. (2035103)
1991
33
Effect of azelastine on platelet-activating factor and antigen-induced pleurisy in rats. (1680710)
1991
34
The usefulness and limitations of adenosine deaminase in the diagnosis of tubercular pleurisy. A meta-analytical study]. (2149157)
1990
35
Tuberculous pleurisy--a family outbreak. (2219465)
1990
36
Doxofylline exerts a prophylactic effect against bronchoconstriction and pleurisy induced by PAF. (2776832)
1989
37
Pharmacological studies on zymosan inflammation in rats and mice. 2: Zymosan-induced pleurisy in rats. (2771857)
1989
38
Participation of lipid peroxidation in rat pertussis vaccine pleurisy. I. Thiobarbituric acid (TBA) reactant and ceruloplasmin. (3240492)
1988
39
Sequential study of pleural peritoneal and blood cells in acute pleurisy induced by calcium pyrophosphate in the rat. (2826118)
1987
40
Comparative effects of carprofen, benoxaprofen and indomethacin on the development and decay phases of a carrageenan pleurisy in the rat. (6475662)
1984
41
Activation of lymphocytes by PPD and PHA is promoted by exudate from BCG-induced pleurisy. (6489488)
1984
42
Contributions to the study of the etiology of serofibrinous pleurisy in Romania, under the present epidemiological conditions. Evaluation of the etiological role of viruses. (6369762)
1984
43
Points to consider when choosing a biopsy method in cases of pleurisy of unknown origin. (6872597)
1983
44
Pathway of onset, development, and decay of carrageenan pleurisy in the rat. (6806127)
1982
45
Evidence that histamine does not participate in carrageenan-induced pleurisy in rat. (7371721)
1980
46
Action of various drugs with anti-inflammatory or anti-rheumatic properties on pleurisy due to Bordetella pertussis hypersensitivity in the rat. (232922)
1979
47
Enzootic pneumonia-pleurisy complex in sheep and lambs. (278919)
1978
48
Turpentine pleurisy in rabbits: a model of pleural fluid acidosis and low pleural fluid glucose. (32820)
1978
49
Pleurisy and methotrexate treatment. (200300)
1977
50
Experimental model of acute inflammation: acetic acid-induced pleurisy in rat. (882594)
1977

Genetic Variations for Pleurisy

About this section

Expression for genes affiliated with Pleurisy

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pleurisy

Search GEO for disease gene expression data for Pleurisy.

Pathways for genes affiliated with Pleurisy

About this section
Sources:
29KEGG, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore
See all sources

Pathways related to Pleurisy according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL18
210.4IL18
3
Hide members
10.3IL2RA, CCL2
4
Hide members
10.3IL8, CCL2
510.3PLA2G6, CCL2
610.2IFNG, IL2RA, IL18
7
Hide members
10.2IL8, IL2RA, IFNG
810.2IL8, IL18, IFNG
910.2CCL2, IFNG, IL18
10
Hide members
10.2CCL3, IFNG, IL2RA
1110.2ALOX5, IFNG, CCL2
12
Hide members
10.2PLA2G7, PLA2G6, PLA2G1B
13
Hide members
10.2ALOX5, PLA2G1B, PLA2G6
14
Hide members
10.1IL8, IL18, MEFV, CCL2
1510.1CCL3, IFNG, IL18, IL8
16
Development PDGF signaling via STATs and NF-kB
Hide members
10.1CCL2, IFNG, CXCL9, IL18
1710.1CCL2, CCL3, CXCL9, IL8
18
Hide members
10.0CCL2, IFNG, IL2RA, IL18, IL8
19
Hide members
10.0CCL3, IFNG, TRB, IL2RA, IL18
20
Hide members
10.0CCL2, CCL3, IFNG, CXCL9, IL8
21
Hide members
9.9PLA2G1B, PLA2G6, IL2RA, CXCL9, CCL3
22
Hide members
9.9CCL2, CCL3, CXCL9, IL2RA, IL18, IL8
23
Hide members
9.9CCL3, CXCL9, IL2RA, PLA2G7, PLA2G6, PLA2G1B
24
Hide members
9.7CCL2, CCL3, CXCL9, IL8, PLA2G7, PLA2G6

Compounds for genes affiliated with Pleurisy

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
See all sources

Compounds related to Pleurisy according to GeneCards/GeneDecks:

(show top 50)    (show all 171)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.8IFNG
2pge24410.7PLA2G7, PDE4A
3endotoxin4410.6MEFV, PLA2G1B, PLA2G7
4pentoxifylline44 1111.6IL18, PDE4A
5rantes4410.6IL2RA, IFNG, CCL3
6indomethacin44 59 28 1113.6PLA2G6, PLA2G1B, ALOX5
7rolipram44 59 2812.6ADA, ALOX5, PDE4A
8tuberculin4410.5IFNG, ADA, IL2RA, IL18
9pdtc4410.5IL8, IL18, CCL2
10prednisolone44 28 1112.5MUC16, IL2RA
11aspartate4410.5CCL2, PDE4A, ALOX5, ADA
12cyclophosphamide44 49 1112.4TRB, IL2RA, CXCL9, MUC16
13il-124410.4IL18, IFNG, IL8, CCL2
14lysophospholipid4410.4CCL2, PLA2G7, PLA2G6, PLA2G1B
155 aminosalicylic acid4410.4ALOX5, IL8, IL2RA, CCL2
16cycloheximide4410.4IL18, CEACAM7, PLA2G6, PLA2G7, PDE4A
17scalaradial4410.4PLA2G6, ALOX5, PLA2G1B
18creatinine4410.4ADA, MUC16, PSG2, LCN1, CXCL9
19groalpha4410.4CCL3, IL8, IL18, CCL2, CXCL9
20neopterin4410.4CCL3, IFNG, IL2RA, IL18, IL8, ADA
21phosphatidylcholine4410.4ALOX5, CCL2, PLA2G1B, PLA2G7
22fmlp4410.4ALOX5, PDE4A, CCL3, ADA, PLA2G1B
23triptolide4410.3IL8, IFNG, CCL3, CCL2
24sulfasalazine44 28 49 1113.3IL8, CCL2, IL2RA, ALOX5
25lipoteichoic acid4410.3IL18, IL8, CCL2, CCL3
26tarc4410.3CXCL9, CCL3, IL8, IFNG, IL18, CCL2
27ccl344 2811.3IL8, CCL3, CCL2, IL18, IFNG, CXCL9
28manoalide4410.3PLA2G1B, PLA2G6, ALOX5
29il 104410.3CCL3, IL8, IFNG, CXCL9, IL2RA, IL18
30aspirin44 49 28 2413.2PLA2G7, PLA2G6, ALOX5, PDE4A, IL2RA, ADA
31lysophosphatidylcholine44 2811.2CCL2, PLA2G7, CXCL9, PLA2G6
325fluorouracil4410.2IL18, IL2RA, PSG2, IFNG, CCL3, CCL2
33sb 20358044 5911.2IL18, CCL3, IFNG, IL8, PLA2G6, ALOX5
34leukotriene b444 59 2412.2CCL3, ALOX5, PLA2G1B, PLA2G7, IL8, CCL2
35polyinosinic-polycytidylic acid4410.2IL8, IL18, IFNG, CCL3
36epinephrine44 11 2412.2PDE4A, CCL3, ALOX5, ADA, IL2RA, IL18
37h2o24410.2CCL3, MUC16, IL2RA, IL18, PLA2G1B, ALOX5
38oxygen44 2411.1CCL3, CCL2, PDE4A, PLA2G1B, IL8, PLA2G7
39actinomycin d4410.1IL8, PLA2G6, PDE4A, IFNG, CCL3, CEACAM7
40dexamethasone44 49 28 1113.1MUC16, PDE4A, CXCL9, ADA, ALOX5, PLA2G1B
41ndga4410.1PLA2G6, IL2RA, ALOX5, PLA2G1B
42txb24410.1PLA2G7, PLA2G6, PLA2G1B, ALOX5
43lactate4410.1ADA, PLA2G1B, IL8, IL18, MUC16, PSG2
44p-bromophenacyl bromide4410.1ALOX5, PLA2G1B, PLA2G6
45cyclosporin a44 28 5912.0TRB, PLA2G6, CCL3, IFNG, IL2RA, IL18
46arginine4410.0PLA2G6, CXCL9, IFNG, IL2RA, IL18, PDE4A
47nitric oxide44 11 2411.9CCL3, PLA2G7, CCL2, IL8, PSG2, PDE4A
48histamine44 28 2411.9IL8, IL18, IL2RA, IFNG, PDE4A, CXCL9
49poly(i-c)449.8CCL3, IL8, IFNG, IL18
50vegf449.8CCL2, ADA, ALOX5, IL8, IL18, IL2RA

GO Terms for genes affiliated with Pleurisy

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pleurisy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.1ADA, IL2RA, CXCL9, IFNG
2extracellular spaceGO:0056159.5ADA, CCL2, CCL3, IFNG, MUC16, CXCL9
3extracellular regionGO:0055769.2LCN1, CCL2, CCL3, IFNG, PSG2, CXCL9

Biological processes related to Pleurisy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interferon-gammaGO:07134610.5IL18, CCL3, CCL2
2lipopolysaccharide-mediated signaling pathwayGO:03166310.4CCL2, CCL3, IL18
3cellular response to organic cyclic compoundGO:07140710.4IL18, CCL3, CCL2
4astrocyte cell migrationGO:04361510.4CCL3, CCL2
5cellular response to interleukin-1GO:07134710.4IL8, CCL3, CCL2
6positive regulation of tumor necrosis factor productionGO:03276010.4CCL3, IFNG, IL18
7cellular response to tumor necrosis factorGO:07135610.4CCL2, CCL3, IL18, IL8
8positive regulation of inflammatory responseGO:05072910.4PLA2G7, IL18, CCL3
9negative regulation of inflammatory responseGO:05072810.4MEFV, IL2RA, ADA
10chemotaxisGO:00693510.3CCL2, CCL3, CXCL9, PLA2G6
11neutrophil chemotaxisGO:03059310.3PLA2G1B, IL8, IFNG, CCL3, CCL2
12lymphocyte chemotaxisGO:04824710.3CCL3, CCL2
13macrophage chemotaxisGO:04824610.3CCL3, CCL2
14MAPK cascadeGO:00016510.2IL18, CCL3, CCL2
15inflammatory responseGO:00695410.2CCL2, CCL3, MEFV, CXCL9, IL18, IL8
16cellular response to lipopolysaccharideGO:07122210.1CCL2, IFNG, IL8
17endoplasmic reticulum unfolded protein responseGO:0309689.9IL8, IFNG, CCL2

Molecular functions related to Pleurisy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent phospholipase A2 activityGO:04749910.3PLA2G6, PLA2G7
2chemokine activityGO:0080099.8IL8, CXCL9, CCL3, CCL2

Products for genes affiliated with Pleurisy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pleurisy

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet