MCID: PLR008
MIFTS: 47

Pleurisy malady

Respiratory diseases category

Summaries for Pleurisy

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Disease Ontology:9 A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs.

MalaCards based summary: Pleurisy is related to pneumonia and tuberculosis. An important gene associated with Pleurisy is ADA (adenosine deaminase), and among its related pathways are Signaling by Interleukins and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds pentostatin and sodium stibogluconate have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and neutrophil, and related mouse phenotypes are hematopoietic system and mortality/aging.

Wikipedia:64 Pleurisy (also known as pleuritis) is an inflammation of the pleura, the lining surrounding the lungs.... more...

Aliases & Classifications for Pleurisy

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Sources:
9Disease Ontology, 11DISEASES, 44Novoseek, 61UMLS, 28ICD9CM, 26ICD10
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Related Diseases for Pleurisy

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Diseases related to Pleurisy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.7PLA2G7, PSG2
2tuberculosis30.6IL2RA, IL18, IFNG, ADA
3malignant mesothelioma30.5ADA, PSG2
4peritonitis30.4ADA, MEFV
5arthritis30.2IL18, IFNG, MEFV
6sarcoidosis30.1ADA, IFNG, IL18, IL2RA
7pleural tuberculosis30.0ADA, PSG2, IFNG, IL18, IL2RA
8leukemia30.0ADA, PSG2, IFNG, IL2RA
9pulmonary sarcoidosis29.9IL2RA, IL18, IFNG
10pulmonary tuberculosis29.9ADA, IFNG, IL18, IL2RA
11colitis29.9IL18, IFNG
12eosinophilia29.8IFNG, IL18, IL2RA
13rheumatoid arthritis29.7ADA, MEFV, IFNG, IL18, IL2RA
14systemic lupus erythematosus29.5PLA2G7, IL2RA, IL18, IFNG, ADA
15ulcerative colitis29.3PLA2G7, IL2RA, IL18, IFNG
16periapical granuloma10.4IL2RA
17brucellosis10.4MEFV
18lung cancer10.4
19malaria10.4IFNG
20pertussis10.4
21pericardial effusion10.3ADA, PSG2
22gamma chain deficiency10.3IL2RA, ADA
23hairy cell leukemia10.3IL2RA, ADA
24mycosis fungoides10.3ADA, IL2RA
25lupus erythematosus10.2
26hemophagocytic lymphohistiocytosis10.2IL18, IL2RA
27chronic granulomatous disease10.2IFNG, ADA
28chronic infantile neurological cutaneous articular syndrome10.2IL18, MEFV
29tuberculoid leprosy10.2IL2RA, IFNG
30tropical spastic paraparesis10.2IL2RA, IFNG
31lupus nephritis10.2IL2RA, IL18
32acute pancreatitis10.2IL18, PSG2
33sezary's disease10.2IFNG, IL2RA
34breast cancer10.2
35blindness10.2
36factor vii deficiency10.2PSG2, IFNG
37atopy10.2IL18, IFNG
38plasmodium falciparum malaria10.1IFNG, IL18
39autoimmune thyroiditis10.1IL2RA, IFNG
40uveitis10.1IFNG, IL2RA
41familial hypercholesterolemia10.1PLA2G7, ADA
42pericarditis10.1ADA, PSG2, MEFV
43hematologic cancer10.1IL2RA, ADA
44hypersensitivity reaction type ii disease10.1IL2RA, IL18
45pleuropneumonia10.1
46pleural empyema10.1
47pneumothorax10.1
48tetanus10.1IL2RA, IFNG
49idiopathic pulmonary fibrosis10.1IL18, IFNG
50juvenile rheumatoid arthritis10.1PLA2G7, IL2RA

Graphical network of the top 20 diseases related to Pleurisy:



Diseases related to pleurisy

Symptoms for Pleurisy

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Drugs & Therapeutics for Pleurisy

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Drug clinical trials:

Search ClinicalTrials for Pleurisy

Search NIH Clinical Center for Pleurisy

Genetic Tests for Pleurisy

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Anatomical Context for Pleurisy

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MalaCards organs/tissues related to Pleurisy:

32
Lung, T cells, Neutrophil, Testes, Nk cells, Breast, Monocytes, Heart, Skin

Animal Models for Pleurisy or affiliated genes

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MGI Mouse Phenotypes related to Pleurisy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0IL2RA, IL18, IFNG, MEFV, ADA
2MP:00107688.0IL2RA, IL18, IFNG, MEFV, ADA
3MP:00053877.9ADA, MEFV, IFNG, IL18, IL2RA
4MP:00053787.7ADA, MEFV, IFNG, IL18, IL2RA

Publications for Pleurisy

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Articles related to Pleurisy:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Polygala molluginifolia A. St.-Hil. and Moq. prevent inflammation in the mouse pleurisy model by inhibiting NF-I_B activation. (24560858)
2014
2
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) preceding tuberculous pleurisy. (24576282)
2014
3
Mycobacterium intracellulare Pleurisy Identified on Liquid Cultures of the Pleural Fluid and Pleural Biopsy. (23579554)
2013
4
PD-1/PD-Ls pathways between CD4(+) T cells and pleural mesothelial cells in human tuberculous pleurisy. (24406080)
2013
5
Combined NMR and GC-MS Analyses Revealed Dynamic Metabolic Changes Associated with the Carrageenan-Induced Rat Pleurisy. (24131325)
2013
6
Lung squamous cell carcinoma combined with tuberculous pleurisy. (23075740)
2012
7
Factors associated with pleurisy in pigs: a case-control analysis of slaughter pig data for England and Wales. (22363407)
2012
8
Carcinomatosis lymphangitis and pleurisy after allo-SCT in two patients with secondary leukemia after breast cancer. (21383684)
2012
9
Mantle cell lymphoma involvement of the pleura and tuberculous pleurisy with pulmonary tuberculosis: a case report and literature review. (21968964)
2012
10
Diagnostic accuracy of T-cell interferon-I^ release assays in tuberculous pleurisy: a meta-analysis. (21299686)
2011
11
Serum trace element levels in tuberculous pleurisy. (20461473)
2011
12
Non-tuberculous mycobacterial pleurisy: an 8-year single-centre experience in Taiwan. (20392359)
2010
13
Evidence of anti-inflammatory effects of pioglitazone in the murine pleurisy model induced by carrageenan. (19716439)
2009
14
Tuberculous pleurisy after tumour necrosis factor-alpha antagonist usage: case report]. (19123083)
2008
15
Corticosteroids for tuberculous pleurisy. (17943759)
2007
16
Antiinflammatory effects of Tacrolimus in a mouse model of pleurisy. (16860713)
2006
17
Diagnostic value of thoracoscopic pleural biopsy for pleurisy under local anaesthesia. (16916393)
2006
18
Pneumocystis carinii pneumonia with pleurisy, platypnoea and orthodeoxia. (12554907)
2003
19
Positive response to oral chemoendocrine combination therapy using 5"-deoxy-5-fluorouridine for locally advanced breast cancer with carcinomatous pleurisy: report of a case. (14669082)
2003
20
Diagnostic tools in tuberculous pleurisy: a direct comparative study. (14582908)
2003
21
Evaluation of suspected tuberculous pleurisy: clinical and diagnostic findings in HIV-1-positive and HIV-negative adults in Uganda. (11495266)
2001
22
Elevated soluble CD26 levels in patients with tuberculous pleurisy. (11573900)
2001
23
Hypoxemia modifies circulating and exudate neutrophil number and functional responses in carrageenin-induced pleurisy in the rat. (10857850)
2000
24
Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice. (10403502)
1999
25
Regulation of prostaglandin production in carrageenan-induced pleurisy by melatonin. (10451019)
1999
26
Relationship between nitric oxide and prostaglandins in carrageenin pleurisy. (9605435)
1998
27
Tuberculous pleurisy is more common in AIDS than in non-AIDS patients with tuberculosis. (9266874)
1997
28
Adenosine deaminase (ADA) isoenzyme analysis in pleural effusions: diagnostic role, and relevance to the origin of increased ADA in tuberculous pleurisy. (8726940)
1996
29
Use of adenosine deaminase as a diagnostic tool for tuberculous pleurisy. (7638812)
1995
30
Anti-inflammatory effect of magnolol, isolated from Magnolia officinalis, on A23187-induced pleurisy in mice. (8583356)
1995
31
Involvement of leukotriene B4 in zymosan-induced rat pleurisy: inhibition of leukocyte infiltration by the 5-lipoxygenase inhibitor T-0757. (8845830)
1995
32
Tuberculous pleurisy after percutaneous needle biopsy of a pulmonary nodule. (7938803)
1994
33
Antiinflammatory action of thielocin A1 beta, a group II phospholipase A2 specific inhibitor, in rat carrageenan-induced pleurisy. (8491510)
1993
34
Effect of treatment with interleukin-1 receptor antagonist on the development of carrageenan-induced pleurisy in the rat. (8491511)
1993
35
Adenosine deaminase activity and isozyme test for differentiation diagnosis of tuberculous pleurisy]. (7923429)
1993
36
Suppression by cetirizine of pleurisy triggered by antigen in actively sensitized rats. (1362160)
1992
37
Adenosine deaminase in rheumatoid pleurisy. (2035103)
1991
38
Anti-inflammatory effects of cyclosporin A (CsA) in carragheenan-induced pleurisy in rats. (2158217)
1990
39
The usefulness and limitations of adenosine deaminase in the diagnosis of tubercular pleurisy. A meta-analytical study]. (2149157)
1990
40
Change of glycosaminoglycan in pus of patients with purulent pleurisy. (2719860)
1989
41
Prevalence of pleurisy in pigs at slaughter. (3218056)
1988
42
Induction of lymphokine-activated killer cells by intrapleural instillations of recombinant interleukin-2 in patients with malignant pleurisy due to lung cancer. (3493843)
1987
43
The reduction of tuberculin-induced pleurisy in the guinea-pig by a gold salt, chloroquine and D-penicillamine. (6115933)
1981
44
Influence of some irritating or immunostimulating substances on experimental pleurisy in the rat. (7406599)
1980
45
Action of various drugs with anti-inflammatory or anti-rheumatic properties on pleurisy due to Bordetella pertussis hypersensitivity in the rat. (232922)
1979
46
Sequelae of pleurisy]. (209523)
1978
47
Immunology of lymphocytes in pleurisy and in effusions due to pleural infiltration by chronic lymphocytic leukemia cells. (310227)
1978
48
An outbreak of pleural mesothelioma and chronic fibrosing pleurisy in the village of Karain/UrgA1p in Anatolia. (663877)
1978
49
Radiological case of the month: Tuberculous pleurisy with spinal dissemination. (875474)
1977
50
Meigs' syndrome and pathogenesis of pleurisy and polyserositis. (13760748)
1960

Variations for Pleurisy

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Expression for genes affiliated with Pleurisy

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Expression patterns in normal tissues for genes affiliated with Pleurisy

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Pathways for genes affiliated with Pleurisy

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Pathways related to Pleurisy according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5IL2RA, IL18
2
Show member pathways
9.4MEFV, IL18
3
Show member pathways
IL-2 Signaling pathway37
9.4IL2RA, IFNG
4
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.4IL2RA, IFNG
5
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.4IFNG, IL2RA
69.4IL2RA, IFNG
79.4IL2RA, IFNG
8
Show member pathways
9.4IFNG, IL2RA
99.3IL18, IFNG
109.3IL18, IFNG
119.3IL18, IFNG
12
Show member pathways
9.3IL18, IFNG
139.3IFNG, IL18
14
Show member pathways
IL27-mediated signaling events37
9.3IFNG, IL18
159.3IFNG, IL18
169.3IFNG, IL18
178.9IL2RA, IL18, IFNG
18
Show member pathways
Immune response IL 12 induced IFN gamma production59
8.9IL2RA, IL18, IFNG
19
Show member pathways
8.9IL2RA, IL18, IFNG
20
Show member pathways
8.9IL2RA, IL18, IFNG
21
Show member pathways
8.9IL2RA, IL18, IFNG
22
Show member pathways
8.9IFNG, IL18, IL2RA
23
Show member pathways
8.9IFNG, IL18, IL2RA
24
Show member pathways
8.7PLA2G7, IL2RA, IL18

Compounds for genes affiliated with Pleurisy

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Compounds related to Pleurisy according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1pentostatin44 60 29 1213.0IL2RA, ADA
2sodium stibogluconate44 1210.8IFNG, ADA
3gluten449.8IL2RA, IL18
4amphotericin b449.7ADA, IFNG
5levamisole44 1210.7IL18, IL2RA
6gold sodium thiomalate449.7IFNG, IL2RA
7pirfenidone44 6010.7IL2RA, IFNG
8ranitidine44 29 25 1212.6ADA, IL18, IL2RA
9il-12449.5IFNG, IL18
102,5-oligoadenylate449.5ADA, IFNG, IL2RA
11indoleamine449.4IL18, IFNG
12methotrexate50 44 1211.4ADA, IL18, IL2RA
13ribavirin44 50 1211.4IL18, IFNG, ADA
14imiquimod44 60 29 1212.3IL18, IFNG
15natalizumab44 1210.3IFNG, IL18, IL2RA
16con a449.3IL2RA, IL18, IFNG
17epinephrine44 25 1211.3IL2RA, IL18, ADA
18il 10449.3IFNG, IL18, IL2RA
19mycophenolate mofetil44 50 1211.3IFNG, IL18, IL2RA
20infliximab44 50 1211.3IFNG, IL18, IL2RA
21pentoxifylline44 1210.3IFNG, IL18, IL2RA
22ifn-alpha449.3IL2RA, IL18, IFNG
23thalidomide44 50 60 1212.3IL2RA, IL18, IFNG
24prednisolone44 29 1211.2IFNG, IL18, IL2RA
25ionomycin449.2IFNG, IL18, IL2RA
26tacrolimus44 50 1211.2IL2RA, IL18, IFNG
27acetylcholine44 50 29 25 1213.1IL2RA, IL18, ADA
28doxorubicin44 50 1211.1ADA, PSG2, IL18, IL2RA
29creatinine449.1ADA, PSG2, IL18, IL2RA
30p002449.1PSG2, IL18, PLA2G7
31rantes449.1IL2RA, IL18, IFNG
32atorvastatin44 50 29 25 1213.0IL18, IL2RA, PLA2G7
33ivig449.0IFNG, IL2RA, PLA2G7
34tuberculin449.0IL2RA, IL18, IFNG, ADA
35neopterin449.0IL2RA, IL18, IFNG, ADA
36indomethacin44 29 60 1211.9IL2RA, IL18, IFNG, ADA
37histamine44 29 2510.9IL2RA, IL18, IFNG, ADA
385fluorouracil448.9PSG2, IFNG, IL18, IL2RA
39cyclosporin a44 29 6010.9IL2RA, IL18, IFNG, ADA
40thymidine44 259.8PSG2, IFNG, IL18, IL2RA
41norepinephrine44 25 1210.8IL2RA, IL18, ADA
42arginine448.8IL2RA, IL18, IFNG, ADA
43aspirin44 50 29 2511.7ADA, IL18, IL2RA, PLA2G7
44vegf448.5IL2RA, IL18, IFNG, PSG2, ADA
45pge2448.4IFNG, IL18, IL2RA, PLA2G7
46endotoxin448.4PLA2G7, IL18, IFNG, MEFV
47cysteine448.4ADA, IFNG, IL18, IL2RA
48nitric oxide44 25 1210.4PLA2G7, IL18, IFNG, PSG2
49estrogen448.4ADA, IL18, IL2RA, PLA2G7
50dexamethasone44 50 29 1211.1ADA, IFNG, IL18, IL2RA, PLA2G7

GO Terms for genes affiliated with Pleurisy

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Cellular components related to Pleurisy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7IL2RA, IFNG, ADA
2extracellular regionGO:0055768.1PLA2G7, IL18, IFNG, PSG2

Biological processes related to Pleurisy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of activated T cell proliferationGO:0421049.2IL2RA, IL18
2positive regulation of inflammatory responseGO:0507299.1PLA2G7, IL18
3negative regulation of inflammatory responseGO:0507289.0IL2RA, MEFV, ADA

Products for genes affiliated with Pleurisy

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Sources for Pleurisy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet