MCID: PLR008
MIFTS: 53

Pleurisy malady

Summaries for Pleurisy

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. the inflamed pleural layers rub against each other every time the lungs expand to breathe in air. this can cause sharp pain with breathing (also called pleuritic chest pain).

MalaCards: Pleurisy is related to tuberculosis and pleural tuberculosis. An important gene associated with Pleurisy is ADA (adenosine deaminase), and among its related pathways are Malaria and Rheumatoid arthritis. The compounds gm-csf and pge2 have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Wikipedia:63 Pleurisy (also known as pleuritis) is an inflammation of the pleura, the lining surrounding the lungs.... more...

Aliases & Classifications for Pleurisy

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 25ICD10
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Related Diseases for Pleurisy

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17GeneCards, 18GeneDecks
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Diseases related to Pleurisy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 216)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.8CCL3, IFNG, CXCL9, IL2RA, IL18, CEACAM7
2pleural tuberculosis30.6ADA, CEACAM7, IL8, IL18, IL2RA, PSG2
3pneumonia30.4PSG2, PDE4A, CCL3, CCL2, IL8, PLA2G7
4sarcoidosis30.3CCL2, CCL3, IFNG, TRB, CXCL9, IL2RA
5lupus erythematosus30.2IL18
6systemic lupus erythematosus30.2CCL2, CCL3, IFNG, TRB, IL2RA, IL18
7arthritis30.2CCL2, CCL3, IFNG, MEFV, TRB, CXCL9
8rheumatoid arthritis30.2CCL2, CCL3, ADA, ALOX5, PLA2G1B, PLA2G6
9malignant mesothelioma30.1MUC16
10leukemia30.1CCL3, IFNG, PSG2, TRB, IL2RA, PLA2G6
11breast cancer30.1ADA, CEACAM7, MUC16, PSG2, CCL3
12pulmonary tuberculosis30.0CCL3, IFNG, MUC16, IL2RA, IL18, ADA
13peritonitis30.0CCL2, ADA, ALOX5, PLA2G6, MUC16, MEFV
14familial mediterranean fever29.8MEFV
15sarcoma29.8ADA
16hepatitis29.8IL18
17dermatomyositis29.8CCL3, MUC16
18synovitis29.8IL8, IL18
19interstitial lung disease29.8CCL2, CCL3, IL8
20mastitis29.8IL8
21chronic lymphocytic leukemia29.8ADA, IL2RA, TRB, PDE4A
22eosinophilia29.8IFNG, PDE4A, IL2RA, IL18, IL8, ALOX5
23encephalomyelitis29.8CCL2, CCL3, IFNG, PDE4A, TRB, ALOX5
24pulmonary sarcoidosis29.8IL18, IL2RA, CXCL9, TRB, IFNG, CCL3
25ulcerative colitis29.8IFNG, PDE4A, IL2RA, IL18, IL8, PLA2G7
26lung cancer10.4
27pertussis10.3
28pleural cancer10.2
29tuberculous pneumothorax10.0
30pneumothorax10.0
31acute myocardial infarction10.0MEFV
32rhinitis10.0IL8
33extrapulmonary tuberculosis10.0ADA
34liver cirrhosis10.0ADA
35multiple myeloma10.0CCL3
36urticaria10.0ALOX5
37alopecia areata10.0IFNG
38leishmaniasis10.0IFNG
39human immunodeficiency virus infectious disease10.0CCL3
40bladder carcinoma10.0PSG2
41hypercholesterolemia10.0PLA2G7
42keratitis10.0CXCL9
43polymyositis10.0CCL3
44vascular disease10.0IL8
45myasthenia gravis10.0IFNG
46nephrotic syndrome10.0IL2RA, PLA2G7
47brucellosis10.0MEFV
48arthropathy10.0ALOX5
49myeloid leukemia10.0TRB
50deficiency anemia10.0MUC16

Graphical network of the top 20 diseases related to Pleurisy:



Diseases related to pleurisy

Clinical Features for Pleurisy

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Drugs & Therapeutics for Pleurisy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pleurisy

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Anatomical Context for Pleurisy

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32MalaCards
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MalaCards organs/tissues related to Pleurisy:

32
Lung, T cells, Testes, Nk cells, Breast, Monocytes, Skin

Animal Models for Pleurisy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pleurisy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.9ADA, PLA2G1B, TRB, MEFV, IFNG, CCL2
2MP:00053979.5CCL2, CCL3, IFNG, MEFV, TRB, IL2RA
3MP:00053819.5CCL2, CCL3, IFNG, TRB, IL2RA, IL18
4MP:00053849.4PHLDA2, IFNG, CCL3, CCL2, MEFV, TRB
5MP:00053879.3ADA, CCL2, CCL3, IFNG, PDE4A, MEFV
6MP:00053789.3PHLDA2, IFNG, CCL3, CCL2, MEFV, TRB

Publications for Pleurisy

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50PubMed
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Articles related to Pleurisy:

(show top 50)    (show all 522)
idTitleAuthorsYear
1
Association between elevated pleural interleukin-33 levels and tuberculous pleurisy. (23301222)
2013
2
Evaluating pleural ADA, ADA2, IFN-I^ and IGRA for diagnosing tuberculous pleurisy. (23796864)
2013
3
Pleural fluid mononuclear cells (PFMCs) from tuberculous pleurisy canA migrate inA vitro in response to CXCL10. (24406079)
2013
4
Carcinomatosis lymphangitis and pleurisy after allo-SCT in two patients with secondary leukemia after breast cancer. (21383684)
2012
5
Mantle cell lymphoma involvement of the pleura and tuberculous pleurisy with pulmonary tuberculosis: a case report and literature review. (21968964)
2012
6
Differentiation and recruitment of IL-22-producing helper T cells stimulated by pleural mesothelial cells in tuberculous pleurisy. (22199006)
2012
7
Diphenyl diselenide reduces inflammation in the mouse model of pleurisy induced by carrageenan: reduction of pro-inflammatory markers and reactive species levels. (22699806)
2012
8
Identification, assessment and management of pleurisy. (21560710)
2011
9
Human natural killer cells expressing the memory-associated marker CD45RO from tuberculous pleurisy respond more strongly and rapidly than CD45RO- natural killer cells following stimulation with interleukin-12. (21711347)
2011
10
A higher significance of anaerobes: the clone library analysis of bacterial pleurisy. (20688923)
2011
11
Effect of compound IMMLG5521, a novel coumarin derivative, on carrageenan-induced pleurisy in rats. (21549112)
2011
12
Trace elements analysis of urine and hair in tuberculous pleurisy. (21286849)
2011
13
5-androstenediol ameliorates pleurisy, septic shock, and experimental autoimmune encephalomyelitis in mice. (21188238)
2010
14
Involvement of nitric oxide in a rat model of carrageenin-induced pleurisy. (20592757)
2010
15
Anti-inflammatory action of a phosphatidylcholine, phosphatidylethanolamine and N-acylphosphatidylethanolamine-enriched diet in carrageenan-induced pleurisy. (18987473)
2009
16
The anti-allergic activity of the acetate fraction of Schinus terebinthifolius leaves in IgE induced mice paw edema and pleurisy. (18672096)
2008
17
Cyclosporin A inhibits CD11a/CD18 adhesion molecules due to inhibition of TNFalpha and IL-1 beta levels in the mouse model of pleurisy induced by carrageenan. (19262158)
2008
18
Corticosteroids for tuberculous pleurisy. (17943759)
2007
19
Transforming growth factor beta-1 as a predictor of fibrosis in tuberculous pleurisy. (17875052)
2007
20
Two patients with tuberculous pleurisy]. (15688842)
2005
21
Pleural fluid and serum procalcitonin as diagnostic tools in tuberculous pleurisy. (15708544)
2005
22
Diagnostic significance of gamma-interferon in tuberculous pleurisy. (15351932)
2004
23
A case of rheumatoid arthritis exhibiting accelerating rheumatoid pleurisy during low-dose weekly methotrexate therapy. (17143704)
2004
24
Positive response to oral chemoendocrine combination therapy using 5"-deoxy-5-fluorouridine for locally advanced breast cancer with carcinomatous pleurisy: report of a case. (14669082)
2003
25
Effects of methotrexate upon inflammatory parameters induced by carrageenan in the mouse model of pleurisy. (12467522)
2002
26
Myeloperoxidase and adenosine-deaminase levels in the pleural fluid leakage induced by carrageenan in the mouse model of pleurisy. (11577999)
2001
27
Role of IL-6 in the pleurisy and lung injury caused by carrageenan. (10528216)
1999
28
Generation of inflammatory cytokines in zymosan-induced pleurisy in rats: TNF induces IL-6 and cytokine-induced neutrophil chemoattractant (CINC) in vivo. (10049519)
1998
29
Characterization of the receptor and the mechanisms underlying the inflammatory response induced by des-Arg9-BK in mouse pleurisy. (9489617)
1998
30
The optimal number of pleural biopsy specimens for a diagnosis of tuberculous pleurisy. (9315802)
1997
31
Pharmacological profile of rat pleurisy induced by Bothrops jararaca venom. (8722506)
1996
32
Suggestive evidence for bromocriptine-induced pleurisy. (8710045)
1996
33
Induction of prostaglandin H synthase-2 in rat carrageenin-induced pleurisy and effect of a selective COX-2 inhibitor. (7732867)
1995
34
Interleukin-8 is a major component of pleural liquid chemotactic activity in a rabbit model of endotoxin pleurisy. (8074236)
1994
35
Evaluation of three culture media and their combinations for the isolation of Mycobacterium tuberculosis from pleural aspirates of patients with tuberculous pleurisy. (8064950)
1994
36
Adenosine deaminase activity and isozyme test for differentiation diagnosis of tuberculous pleurisy]. (7923429)
1993
37
Cooperation between accessory cells and T lymphocytes in patients with tuberculous pleurisy. (1914556)
1991
38
Participation of lipid peroxidation in rat pertussis vaccine pleurisy. III. Thiobarbituric acid (TBA) reactant and lysosomal enzyme. (2054877)
1991
39
Clinical significance of serum CA125 in patients with tuberculous pleurisy]. (1921093)
1991
40
Treatment of malignant ascites and pleurisy by a streptococcal preparation OK-432 with fresh frozen plasma--a mechanism of polymorphonuclear leukocyte (PMN) accumulation. (2539336)
1989
41
Purified protein derivative induced cytotoxicity in carcinomatous and tuberculous pleurisy. (2461459)
1988
42
Time course analyses of kinins and other mediators in plasma exudation of rat kaolin-induced pleurisy. (3065090)
1988
43
Changes of Cu & Zn in carrageenan pleurisy and paw-oedema in rat. (3174799)
1988
44
Characteristic and specific histological findings in rheumatoid pleurisy. (2421531)
1986
45
Frequency of tuberculin-reactive T-lymphocytes in pleural fluid and blood from patients with tuberculous pleurisy. (3485515)
1986
46
Effects of several anti-inflammatory drugs on the various parameters involved in the inflammatory response in rat carrageenin-induced pleurisy. (6583058)
1983
47
Sarcoidosis presenting with pleurisy and bilateral pleural effusions. (7433329)
1980
48
The pulmonary angiographic appearance of pleurisy associated with subdiaphragmatic inflammation. (483191)
1979
49
Chronic pleurisy in systemic lupus erythematosus treated with pleurectomy. (553667)
1979
50
Radiological case of the month: Tuberculous pleurisy with spinal dissemination. (875474)
1977

Genetic Variations for Pleurisy

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Expression for genes affiliated with Pleurisy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleurisy

Search GEO for disease gene expression data for Pleurisy.

Pathways for genes affiliated with Pleurisy

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29KEGG, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore
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Pathways related to Pleurisy according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL18
210.4IL18
3
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10.3IL2RA, CCL2
4
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10.3IL8, CCL2
510.3PLA2G6, CCL2
610.2IFNG, IL2RA, IL18
7
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10.2IL8, IL2RA, IFNG
810.2IL8, IL18, IFNG
910.2CCL2, IFNG, IL18
10
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10.2CCL3, IFNG, IL2RA
1110.2ALOX5, IFNG, CCL2
12
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10.2PLA2G7, PLA2G6, PLA2G1B
13
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10.2ALOX5, PLA2G1B, PLA2G6
14
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10.1IL8, IL18, MEFV, CCL2
1510.1CCL3, IFNG, IL18, IL8
16
Development PDGF signaling via STATs and NF-kB
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10.1CCL2, IFNG, CXCL9, IL18
1710.1CCL2, CCL3, CXCL9, IL8
18
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10.0CCL2, IFNG, IL2RA, IL18, IL8
19
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10.0CCL3, IFNG, TRB, IL2RA, IL18
20
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10.0CCL2, CCL3, IFNG, CXCL9, IL8
21
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9.9PLA2G1B, PLA2G6, IL2RA, CXCL9, CCL3
22
Hide members
9.9CCL2, CCL3, CXCL9, IL2RA, IL18, IL8
23
Hide members
9.9CCL3, CXCL9, IL2RA, PLA2G7, PLA2G6, PLA2G1B
24
Hide members
9.7CCL2, CCL3, CXCL9, IL8, PLA2G7, PLA2G6

Compounds for genes affiliated with Pleurisy

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Pleurisy according to GeneCards/GeneDecks:

(show top 50)    (show all 171)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.8IFNG
2pge24410.7PLA2G7, PDE4A
3endotoxin4410.6MEFV, PLA2G1B, PLA2G7
4pentoxifylline44 1111.6IL18, PDE4A
5rantes4410.6IL2RA, IFNG, CCL3
6indomethacin44 59 28 1113.6PLA2G6, PLA2G1B, ALOX5
7rolipram44 59 2812.6ADA, ALOX5, PDE4A
8tuberculin4410.5IFNG, ADA, IL2RA, IL18
9pdtc4410.5IL8, IL18, CCL2
10prednisolone44 28 1112.5MUC16, IL2RA
11aspartate4410.5CCL2, PDE4A, ALOX5, ADA
12cyclophosphamide44 49 1112.4TRB, IL2RA, CXCL9, MUC16
13il-124410.4IL18, IFNG, IL8, CCL2
14lysophospholipid4410.4CCL2, PLA2G7, PLA2G6, PLA2G1B
155 aminosalicylic acid4410.4ALOX5, IL8, IL2RA, CCL2
16cycloheximide4410.4IL18, CEACAM7, PLA2G6, PLA2G7, PDE4A
17scalaradial4410.4PLA2G6, ALOX5, PLA2G1B
18creatinine4410.4ADA, MUC16, PSG2, LCN1, CXCL9
19groalpha4410.4CCL3, IL8, IL18, CCL2, CXCL9
20neopterin4410.4CCL3, IFNG, IL2RA, IL18, IL8, ADA
21phosphatidylcholine4410.4ALOX5, CCL2, PLA2G1B, PLA2G7
22fmlp4410.4ALOX5, PDE4A, CCL3, ADA, PLA2G1B
23triptolide4410.3IL8, IFNG, CCL3, CCL2
24sulfasalazine44 28 49 1113.3IL8, CCL2, IL2RA, ALOX5
25lipoteichoic acid4410.3IL18, IL8, CCL2, CCL3
26tarc4410.3CXCL9, CCL3, IL8, IFNG, IL18, CCL2
27ccl344 2811.3IL8, CCL3, CCL2, IL18, IFNG, CXCL9
28manoalide4410.3PLA2G1B, PLA2G6, ALOX5
29il 104410.3CCL3, IL8, IFNG, CXCL9, IL2RA, IL18
30aspirin44 49 28 2413.2PLA2G7, PLA2G6, ALOX5, PDE4A, IL2RA, ADA
31lysophosphatidylcholine44 2811.2CCL2, PLA2G7, CXCL9, PLA2G6
325fluorouracil4410.2IL18, IL2RA, PSG2, IFNG, CCL3, CCL2
33sb 20358044 5911.2IL18, CCL3, IFNG, IL8, PLA2G6, ALOX5
34leukotriene b444 59 2412.2CCL3, ALOX5, PLA2G1B, PLA2G7, IL8, CCL2
35polyinosinic-polycytidylic acid4410.2IL8, IL18, IFNG, CCL3
36epinephrine44 11 2412.2PDE4A, CCL3, ALOX5, ADA, IL2RA, IL18
37h2o24410.2CCL3, MUC16, IL2RA, IL18, PLA2G1B, ALOX5
38oxygen44 2411.1CCL3, CCL2, PDE4A, PLA2G1B, IL8, PLA2G7
39actinomycin d4410.1IL8, PLA2G6, PDE4A, IFNG, CCL3, CEACAM7
40dexamethasone44 49 28 1113.1MUC16, PDE4A, CXCL9, ADA, ALOX5, PLA2G1B
41ndga4410.1PLA2G6, IL2RA, ALOX5, PLA2G1B
42txb24410.1PLA2G7, PLA2G6, PLA2G1B, ALOX5
43lactate4410.1ADA, PLA2G1B, IL8, IL18, MUC16, PSG2
44p-bromophenacyl bromide4410.1ALOX5, PLA2G1B, PLA2G6
45cyclosporin a44 28 5912.0TRB, PLA2G6, CCL3, IFNG, IL2RA, IL18
46arginine4410.0PLA2G6, CXCL9, IFNG, IL2RA, IL18, PDE4A
47nitric oxide44 11 2411.9CCL3, PLA2G7, CCL2, IL8, PSG2, PDE4A
48histamine44 28 2411.9IL8, IL18, IL2RA, IFNG, PDE4A, CXCL9
49poly(i-c)449.8CCL3, IL8, IFNG, IL18
50vegf449.8CCL2, ADA, ALOX5, IL8, IL18, IL2RA

GO Terms for genes affiliated with Pleurisy

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16Gene Ontology
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Cellular components related to Pleurisy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.1ADA, IL2RA, CXCL9, IFNG
2extracellular spaceGO:0056159.5ADA, CCL2, CCL3, IFNG, MUC16, CXCL9
3extracellular regionGO:0055769.2LCN1, CCL2, CCL3, IFNG, PSG2, CXCL9

Biological processes related to Pleurisy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interferon-gammaGO:07134610.5IL18, CCL3, CCL2
2lipopolysaccharide-mediated signaling pathwayGO:03166310.4CCL2, CCL3, IL18
3cellular response to organic cyclic compoundGO:07140710.4IL18, CCL3, CCL2
4astrocyte cell migrationGO:04361510.4CCL3, CCL2
5cellular response to interleukin-1GO:07134710.4IL8, CCL3, CCL2
6positive regulation of tumor necrosis factor productionGO:03276010.4CCL3, IFNG, IL18
7cellular response to tumor necrosis factorGO:07135610.4CCL2, CCL3, IL18, IL8
8positive regulation of inflammatory responseGO:05072910.4PLA2G7, IL18, CCL3
9negative regulation of inflammatory responseGO:05072810.4MEFV, IL2RA, ADA
10chemotaxisGO:00693510.3CCL2, CCL3, CXCL9, PLA2G6
11neutrophil chemotaxisGO:03059310.3PLA2G1B, IL8, IFNG, CCL3, CCL2
12lymphocyte chemotaxisGO:04824710.3CCL3, CCL2
13macrophage chemotaxisGO:04824610.3CCL3, CCL2
14MAPK cascadeGO:00016510.2IL18, CCL3, CCL2
15inflammatory responseGO:00695410.2CCL2, CCL3, MEFV, CXCL9, IL18, IL8
16cellular response to lipopolysaccharideGO:07122210.1CCL2, IFNG, IL8
17endoplasmic reticulum unfolded protein responseGO:0309689.9IL8, IFNG, CCL2

Molecular functions related to Pleurisy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent phospholipase A2 activityGO:04749910.3PLA2G6, PLA2G7
2chemokine activityGO:0080099.8IL8, CXCL9, CCL3, CCL2

Products for genes affiliated with Pleurisy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pleurisy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet