Pleurisy malady

Disease Ontology: A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. the inflamed pleural layers rub against each other every time the lungs expand to breathe in air. this can cause sharp pain with breathing (also called pleuritic chest pain).⁶

MalaCards: Pleurisy is related to pleural tuberculosis and tuberculosis. An important gene associated with Pleurisy is ADA (adenosine deaminase), and among its related pathways are Bacterial infections in CF airways and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds cyclophosphamide and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include lung, monocytes and nk cells, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia: Pleurisy (also known as pleuritis) is an inflammation of the pleura, the lining of the pleural cavity...⁴⁴ more...

Aliases & Descriptions:

pleurisy 6 8 32 43

Diseases related to pleurisy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 865)

id	Related Disease	Score	Top Affiliating Genes
1	pleural tuberculosis	31.1	IL18, IFNG, TNF, ADA
2	tuberculosis	29.6	IL10, IL1B, IL1RN, CCL2, IFNG, TNF
3	mycobacterium tuberculosis	27.5	CCL2, TNF, SLC11A1
4	arthritis	27.0	IL17A, IL1B, IL8, TNF
5	pulmonary tuberculosis	26.8	MUC16, IL10, IL18, IL2, IL2RA, CCL3
6	angiosarcoma	26.3	VIM, IL2, TP53, CRP
7	rheumatoid arthritis	26.1	IL10, IL1B, IL1RN, IL2, TNF
8	familial mediterranean fever	24.3	MEFV, IL10, IL18, IL1B, IL1RN, IL2RA
9	sjogren's syndrome	23.0	MUC16, LCN1, IL10, IL17A, IL18, IL1B
10	fibrosis	18.0	PDE4A, VIM, LCN1, MPO, GRP, IL10
11	tuberculous peritonitis	13.8	MUC16, ADA
12	mucinous ovarian cystadenoma	13.8	MUC16, CEACAM7, PSG2
13	extrinsic allergic alveolitis	13.7	IL18, IL8, CCL3
14	congenital hemolytic anemia	13.6	IL3, IFNG, ADA
15	blepharitis	13.6	IFNG, PLA2G1B, PLA2G6
16	tuberculoid leprosy	13.6	IL10, IL2RA, IFNG
17	mast-cell leukemia	13.6	MPO, CCL2, CCL3
18	bronchogenic carcinoma	13.6	CEACAM7, ENO2, KRT19, PSG2
19	secretory meningioma	13.6	VIM, CEACAM7, PSG2
20	paranasal sinus disease	13.5	IL17A, IL5, IFNG
21	pericardial effusion	13.5	VIM, MUC16, PSG2, ADA
22	cutaneous leishmaniasis	13.5	IL10, IFNG
23	african tick-bite fever	13.5	IL10, CCL3, IFNG
24	mucinous cystadenocarcinoma	13.5	VIM, MUC16, CEACAM7, PSG2
25	henoch-schoenlein purpura	13.5	MPO, MEFV, ICAM1
26	pseudomyxoma peritonei	13.5	VIM, CEACAM7, PSG2
27	pulmonary emphysema	13.5	GRP, IL18, IL8, IFNG
28	visceral leishmaniasis	13.5	IL10, IFNG, SLC11A1
29	t-cell large granular lymphocyte leukemia	13.5	IL18, IL2, TRB@
30	vogt-koyanagi-harada disease	13.5	IL17A, IL2RA, IFNG, ICAM1
31	autoimmune thyroiditis	13.4	IL2RA, IFNG, ICAM1, KRT19
32	allergic conjunctivitis	13.4	IL5, IL8, IFNG, ICAM1
33	viral meningitis	13.4	IL8, CRP, ADA
34	diffuse infiltrative lymphocytosis syndrome	13.4	IL2, IL2RA, TRB@
35	htlv-1 associated myelopathy	13.4	IL2, IL2RA, CCL3
36	gastric cancer risk after h. pylori infection	13.4	IL1B, IL1RN
37	thyroid medullary carcinoma	13.4	GRP, ENO2, KRT19, PSG2
38	chronic eosinophilic pneumonia	13.4	IL10, IL5, CXCL9
39	slow-channel congenital myasthenic syndrome	13.4	IL8, CRP
40	temporal arteritis	13.4	CCL2, IFNG, CRP
41	urinary schistosomiasis	13.4	IL10, IL5, IFNG
42	felty's syndrome	13.4	IL10, IL3, IL8
43	gamma chain deficiency	13.3	IL2, IL2RA, ADA
44	stachybotrys chartarum	13.3	IL18, IL1B, IL3, CCL3
45	plasmodium falciparum malaria	13.3	IL10, IL18, IFNG, ICAM1
46	eosinophilic fasciitis	13.3	IL10, IL5, IFNG, TRB@
47	egg allergy	13.3	IL2, IL5, IFNG
48	factor vii deficiency	13.3	MUC16, IL2, IFNG, TRB@, PSG2
49	persistent hyperinsulinemic hypoglycemia of infancy	13.3	VIM, ENO2, KRT19
50	hypersensitivity reaction type iv disease	13.3	IL2, IFNG, ICAM1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pleurisy:

²²

MGI Mouse Phenotypes related to pleurisy:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.6	ADA
2	hematopoietic system phenotype	MP:0005397	9.3	ADA, KIAA0101, MEFV, IL17A, IL3, IL5
3	integument phenotype	MP:0010771	9.0	TLR4, TLR2, KRT19, PTGES, TP53, TRB@
4	liver/biliary system phenotype	MP:0005370	8.9	ADA, TLR4, TLR2, PLA2G1B, TP53, TRB@
5	digestive/alimentary phenotype	MP:0005381	8.8	KRT19, TLR2, TGFB1, SLC11A1, PLA2G1B, TRB@
6	skeleton phenotype	MP:0005390	8.7	ADA, KRT19, PLA2G6, PTGS2, TP53, ALOX5
7	nervous system phenotype	MP:0003631	8.6	TGFB1, TLR4, TLR2, KRT19, PLA2G6, TRB@
8	growth/size phenotype	MP:0005378	8.3	ADA, TLR4, KRT19, PHLDA2, PLA2G6, PLA2G1B
9	mortality/aging	MP:0010768	7.9	PLA2G6, KRT19, TLR2, TLR4, CXCL9, SLC11A1
10	behavior/neurological phenotype	MP:0005386	7.9	IFNG, PTGES, PLA2G6, TLR2, TLR4, CCL3
11	immune system phenotype	MP:0005387	7.8	TLR4, SLC11A1, PLA2G6, PTGES, PDE4A, KIAA0101
12	reproductive system phenotype	MP:0005389	7.5	TGFB1, TLR4, KRT19, PLA2G6, PTGS2, TNF
13	adipose tissue phenotype	MP:0005375	7.4	PLA2G1B, TLR2, TLR4, TGFB1, PTGS2, TNF
14	vision/eye phenotype	MP:0005391	7.0	TLR4, PTGS2, TNF, TP53, ICAM1, IFNG
15	muscle phenotype	MP:0005369	6.9	TNF, PTGS2, PLA2G6, TLR2, TGFB1, TP53
16	tumorigenesis	MP:0002006	5.6	TNF, PTGS2, KRT19, TLR2, TLR4, TGFB1
17	homeostasis/metabolism phenotype	MP:0005376	4.7	PLA2G1B, CRP, PTGS2, PTGES, KLKB1, TLR2
18	cellular phenotype	MP:0005384	4.5	PTGES, TNF, TP53, TRB@, ALOX5, PTGS2
19	cardiovascular system phenotype	MP:0005385	4.4	TP53, TNF, PTGS2, CRP, KRT19, KLKB1

Articles related to pleurisy:

(show top 50)    (show all 81)

id	Title	Authors	Year	Affiliating Genes
1	Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy. (19552525)	Chen X.... Zhou B.	2009	TLR2, IL17A
2	The diagnostic value of adenosine deaminase coeffici ent in patients with tuberculous exudative pleurisy (19514456)	Shirinkina A.E.... Milashina E.N.	2009	ADA
3	Could IFN-gamma predict the development of residual pleural thickening in tuberculous pleurisy? (18507195)	Gerogianni I.... Gourgoulianis K.I.	2008	ADA, IFNG
4	Autopsy case of diffuse pleural thickening presenting respiratory impairment and benign asbestos pleurisy (18517012)	Morokawa N.... Kawabata Y.	2008	ADA
5	Diagnostic utility of interferon-gamma-induced protein of 10 kDa (IP-10) in tuberculous pleurisy. (18620834)	Supriya P.... Das S.D.	2008	IL8, CXCL9
6	Pleural fluid adenosine deaminase and interferon gamma as diagnostic tools in tuberculosis pleurisy. (19218659)	Krenke R.... Chazan R.	2008	ADA, IFNG
7	Increased pleural soluble fas ligand (sFasL) levels in tuberculosis pleurisy and its relation with T-helper type 1 cytokines. (18663530)	Budak F.... Oral H.B.	2008	IL8, IL18, IFNG
8	Adenosine deaminase in the blood cells and serum of patients with tuberculous pleurisy (18318225)	Alinezhad S.M.... Taganovich A.D.	2008	ADA
9	Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: a meta-analysis. (18222681)	Liang Q.L.... Qin X.J.	2008	ADA
10	Diagnostic characteristics of adenosine deaminase test in Byelorussian patients with tuberculous pleurisy (18822475)	Taganovich A.D.... Alinezhad S.M.	2008	ADA
11	Gamma-interferon and adenosine deaminase in the diagnosis of tuberculous pleurisy (19227321)	Titarenko O.T.... Popov M.I.u.	2008	ADA, IFNG
12	Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy. (17709420)	Schierloh P.... Sasiain M.C.	2007	TLR2, TLR4, IFNG
13	Pleural fluid neopterin levels in tuberculous pleurisy. (17531216)	Cok G.... Bayindir O.	2007	ADA, IFNG
14	Diagnostic value of interferon-gamma in tuberculous pleurisy: a metaanalysis. (17426220)	Jiang J.... Qin X.J.	2007	IFNG
15	A case of tuberculous pleurisy with a rapid decrease in pleural effusion (18051793)	Tokuyasu H.... Eiji S.	2007	ADA
16	Transforming growth factor beta-1 as a predictor of fibrosis in tuberculous pleurisy. (17875052)	Seiscento M.... Teixeira L.R.	2007	TGFB1
17	Autoantibodies against tumour suppressor protein p53 in pleural effusions of patients with tuberculosis pleurisy. (17270093)	Wang L.... Shiau M.Y.	2007	TP53, ADA
18	Bilateral massive bloody pleurisy complicated by angiosarcoma. (17268128)	Moriya Y.... Takahashi H.	2007	VIM
19	Diagnostic value of serum and pleural fluid adenosine deaminase activity in tuberculous pleurisy (16698563)	Smach M.A.... Limem K.	2006	ADA
20	Two patients with tuberculous pleurisy (15688842)	er Steege R.W.... van A.R.	2005	ADA, IFNG
21	The diagnostic values of serum, pleural fluid and urine neopterin measurements in tuberculous pleurisy. (16158898)	Tozkoparan E.... Ekiz K.	2005	ADA
22	Clinical investigation on diagnostic value of interferon-gamma, interleukin-12 and adenosine deaminase isoenzyme for tuberculous pleurisy. (15740654)	Gao Z.C.... Tian R.X.	2005	IFNG
23	Clinical investigation of the diagnostic value of interferon-gamma, interleukin-12 and adenosine deaminase isoenzyme in tuberculous pleurisy (15312552)	Tian R.X.... Gao Z.C.	2004	IFNG
24	Interleukin-8 production in tuberculous pleurisy: role of mesothelial cells stimulated by cytokine network involving tumour necrosis factor-alpha and interleukin-1 beta. (12753503)	Park J.S.... Lee K.Y.	2003	IL8
25	Diagnostic tools in tuberculous pleurisy: a direct comparative study. (14582908)	Diacon A.H.... Walzl G.	2003	ADA
26	Activity of pleural fluid adenosine deaminase in tuberculous pleurisy (11899804)	Mardanian S.S.... Markarian N.R.	2002	ADA
27	Elevated soluble CD26 levels in patients with tuberculous pleurisy. (11573900)	Oshikawa K.... Sugiyama Y.	2001	ADA, IFNG
28	Pleurisy: diagnostic and therapeutic management (10793945)	Sardet A.	2000	ADA
29	Intrapleural therapy with MDP-Lys (L18), a synthetic derivative of muramyl dipeptide, against malignant pleurisy associated with lung cancer. (10688489)	Yanagawa H.... Sone S.	2000	IL1B
30	Parameters relating to the development of residual pleural thickening in tuberculous pleurisy (10191601)	Nagayama N.... Hayashi K.	1999	LCN1
31	Mycobacterium-induced transmesothelial migration of monocytes into pleural space: role of intercellular adhesion molecule-1 in tuberculous pleurisy. (10515824)	Nasreen N.... Antony V.B.	1999	ICAM1
32	Mycobacterium-mediated chemokine expression in pleural mesothelial cells: role of C-C chemokines in tuberculous pleurisy. (9780267)	Mohammed K.A.... Antony V.B.	1998	CCL2, CCL3
33	Cell-mediated immune responses and cytotoxicity to mycobacterial antigens in patients with tuberculous pleurisy in Brazil. (9776139)	Arruda S.... Barral-Netto M.	1998	IL10
34	Compartmentalization of pro-inflammatory cytokines in tuberculous pleurisy. (9519218)	Hoheisel G.... Perruchoud A.P.	1998	IL8
35	Levels of interleukin-8 in tuberculous pleurisy and the profile of immunocompetent cells in pleural and peripheral compartments. (9093879)	Dlugovitzky D.... Bottasso O.	1997	IL8
36	Differential diagnosis of tuberculous pleurisy by measurement of cytokine concentrations in pleural effusion. (9666960)	Ogawa K.... Kohno S.	1997	ADA, IFNG
37	Pleural fluid interferon-gamma and tumour necrosis factor-alpha in tuberculous and rheumatoid pleurisy. (8866589)	SAPderblom T.... Pettersson T.	1996	IFNG
38	Commemorative lecture of receiving Imamura Memorial Prize. Analysis of cellular immunity against tuberculosis in man with special reference to tuberculous pleurisy and cytokines (8936994)	Shimokata K.	1996	IL2, IFNG
39	Adenosine deaminase (ADA) isoenzyme analysis in pleural effusions: diagnostic role, and relevance to the origin of increased ADA in tuberculous pleurisy. (8726940)	Valdes L.... Valle J.M.	1996	ADA
40	Tuberculous pleurisy and adenosine deaminase. (7638795)	Bothamley G.H.	1995	ADA
41	Diagnosis of tuberculous pleurisy using the biologic parameters adenosine deaminase, lysozyme, and interferon gamma. (8432137)	ValdAcs L.... RodrA-guez SuA!rez J.R.	1993	ADA, IFNG
42	Adenosine deaminase activity and isozyme test for differentiation diagnosis of tuberculous pleurisy (7923429)	Luo S.W.... Li L.	1993	ADA
43	Quinacrine-induced pleural inflammation in malignant pleurisy: relation between drainage time of pleural fluid and local interleukin-1 beta levels. (8290803)	Agrenius V.... Svenson S.B.	1993	IL1B
44	Effect of postoperative intrapleural instillations of interleukin-2 in patients with malignant pleurisy due to lung cancer. (8398572)	Yasumoto K.... Nomoto K.	1993	IL2
45	Clinical significance of serum CA125 in patients with tuberculous pleurisy (1921093)	Nakanishi Y.... Yamada H.	1991	MUC16
46	Adenosine deaminase in rheumatoid pleurisy. (2035103)	Akama H.... Tsuji S.	1991	ADA
47	Cytokine content in pleural effusion. Comparison between tuberculous and carcinomatous pleurisy. (1902158)	Shimokata K.... Hasegawa T.	1991	IFNG
48	Eosinophil colony-stimulating factor induced by administration of interleukin-2 into the pleural cavity of patients with malignant pleurisy. (2206537)	Nakamura Y.... Ogura T.	1990	IL2, IL3, IL5
49	The usefulness and limitations of adenosine deaminase in the diagnosis of tubercular pleurisy. A meta-analytical study (2149157)	Ena J.... EnrA-quez de Salamanca R.	1990	ADA
50	Soluble interleukin-2 receptor in the serum and the pleural fluid in patients with tuberculous pleurisy (2281539)	Hamzaoui A.... Ayed K.	1990	IL2RA

Genes related to pleurisy according to GeneCards:

(show all 48)

id	Symbol	Description	Score	GeneCards Section Context
1	ADA	adenosine deaminase	11.0	Publications
2	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0
3	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
4	LCN1	lipocalin 1	11.0	Publications
5	CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	11.0	Publications
6	MEFV	Mediterranean fever	11.0
7	PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	11.0
8	MUC16	mucin 16, cell surface associated	11.0	Publications
9	IFNG	interferon, gamma	11.0	Publications
10	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
11	PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	11.0
12	PDE4A	phosphodiesterase 4A, cAMP-specific	11.0
13	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
14	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
15	ALOX5	arachidonate 5-lipoxygenase	11.0
16	IL8	interleukin 8	11.0	Publications
17	TRB@	T cell receptor beta locus	11.0	Publications
18	PHLDA2	pleckstrin homology-like domain, family A, member 2	11.0
19	KIAA0101	KIAA0101	11.0
20	KLKB1	kallikrein B, plasma (Fletcher factor) 1	11.0
21	PLA2G1B	phospholipase A2, group IB (pancreas)	11.0
22	PTGES	prostaglandin E synthase	11.0
23	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
24	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	11.0	Publications
25	EPRS	glutamyl-prolyl-tRNA synthetase	11.0	Publications
26	ALDH9A1	aldehyde dehydrogenase 9 family, member A1	11.0	Publications
27	APLF	aprataxin and PNKP like factor	11.0
28	GRP	gastrin-releasing peptide	11.0	Publications
29	KRT19	keratin 19	11.0	Publications
30	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
31	IL17A	interleukin 17A	11.0	Publications
32	VIM	vimentin	11.0	Publications
33	TLR4	toll-like receptor 4	11.0	Publications
34	TLR2	toll-like receptor 2	11.0	Publications
35	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
36	MPO	myeloperoxidase	11.0	Publications
37	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
38	ICAM1	intercellular adhesion molecule 1	11.0	Publications
39	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
40	IL1B	interleukin 1, beta	11.0	Publications
41	IL10	interleukin 10	11.0	Publications
42	IL2	interleukin 2	11.0	Publications
43	KNG1	kininogen 1	11.0
44	TNF	tumor necrosis factor	11.0	Publications
45	TGFB1	transforming growth factor, beta 1	11.0	Publications
46	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0
47	CRP	C-reactive protein, pentraxin-related	11.0	Publications
48	TP53	tumor protein p53	11.0	Publications

Pathways related to pleurisy according to GeneDecks:

(show top 50)    (show all 93)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.4	TLR2
2	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.1	IL2RA, IL2, CCL3
3	RAR-Gamma-RXR-Alpha Degradation36	10.0	CXCL9, CCL3, IL3, IL2
4	NFAT Signaling and Lymphocyte Interactions36	9.7	CCL2, CCL3, IL2, IL3, IL5
5	Regulation of eIF4 and p70S6K36	9.6	IL18, IL2, IL3, IL5, CCL3
6	Immune System38	9.4	IL3, IL18, IFNG, ICAM1, MEFV, IL5
7	IL-6 Pathway36	9.4	IL10, IL18, IL3, IL5, IL8, CCL2
8	Amoebiasis20	9.4	TLR2, IL8, IL1B, TGFB1, TLR4
9	LDL Oxidation in Atherogenesis36	9.3	CCL2, IL1B, MPO, CCL3, ICAM1, TNF
10	PGC1Alpha Pathway36	9.3	IL3, IL8, CCL3, IL18, IL1B, IL2
11	NOD-like receptor signaling pathway20	9.3	IL18, MEFV, IL1B, IL8, CCL2, TNF
12	THC Differentiation Pathway36	9.2	IL10, IFNG, IL18, IL2, IL2RA, TNF
13	MSP-RON Signaling36	9.2	IL18, TLR2, KLKB1, TNF, IFNG, CCL2
14	Akt Signaling36	9.1	IL2RA, IL2, IL18, IL10, TNF, CXCL9
15	African trypanosomiasis20	9.1	TNF, IFNG, IL1B, IL18, IL10, ICAM1
16	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.1	TGFB1, TLR4, IL17A, IL1B, IFNG, TLR2
17	Th1 Differentiation37	9.0	IL10, IL2, IL18, TLR4, TLR2, TNF
18	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.9	IL10, IL2, IL2RA, TNF, TGFB1
19	Toll-like receptor signaling pathway20	8.9	IL8, CCL3, IL1B, CXCL9, TLR4, TLR2
20	Immune response MIF-mediated glucocorticoid regulation10	8.8	IL2, IL8, IFNG, PTGS2, TNF, ICAM1
21	Immune response_MIF-mediated glucocorticoid regulation41	8.8	PTGS2, TNF, ICAM1, IFNG, IL8, IL2
22	Endothelin-1 Signaling Pathway36	8.8	CXCL9, IL10, PLA2G1B, CCL3, IL5, IL3
23	SOCS Pathway36	8.8	CCL2, CCL3, IL8, IL5, IL2, IL1B
24	Influenza A20	8.7	IL18, IFNG, IL1B, IL8, ICAM1, TNF
25	Molecular Mechanisms of Cancer36	8.6	CXCL9, TGFB1, IL2, TP53, IL5, IL3
26	Immune response CD16 signaling in NK cells10	8.6	IL3, IFNG, TNF, PLA2G1B, PLA2G6, PLA2G7
27	Toxoplasmosis20	8.6	ALOX5, IL10, TNF, PLA2G6, PLA2G1B, TLR2
28	Cytokine Network36	8.6	TNF, IFNG, IL8, IL5, IL3, IL2
29	Chagas disease (American trypanosomiasis)20	8.5	TGFB1, TLR4, TLR2, IFNG, CCL3, CCL2
30	Immune response MIF in innate immunity response10	8.5	IL1B, IL8, IFNG, TP53, TNF, TLR4
31	Immune response_MIF in innate immunity response41	8.5	TLR4, IL8, IFNG, TNF, TP53, PTGS2
32	ERK Signaling36	8.3	IL2, IL5, IL1B, CXCL9, TGFB1, CCL3
33	PEDF Induced Signaling36	8.3	CCL3, IL10, IL8, IL18, CXCL9, IL1B
34	Glucocorticoid Receptor Signaling36	8.2	IL10, IL18, IL2, IL1B, CCL2, IL5
35	TGF-Beta Pathway36	8.2	IL5, IL8, CCL2, CCL3, TGFB1, IL3
36	STAT3 Pathway36	8.2	IL2RA, IL3, IL5, IL8, IL2, IL18
37	Tec Kinases Signaling36	8.1	IL5, CCL3, IL8, CCL2, IL3, IL2RA
38	Rheumatoid arthritis20	8.1	IL17A, IL18, IL1B, TGFB1, TLR4, TLR2
39	Rho Family GTPases36	8.1	CCL2, IL8, IL3, IL2, IL1B, IL18
40	Malaria20	8.1	IFNG, CCL2, IL8, IL1B, IL18, IL10
41	JAK-STAT Pathway36	8.1	IL3, IFNG, CCL3, CCL2, IL5, IL10
42	Leishmaniasis20	8.0	TLR2, IFNG, IL1B, IL10, TGFB1, TNF
43	MAPK Family Pathway36	7.8	IL2RA, IL1B, IL3, IL5, IL8, CCL2
44	PAK Pathway36	7.7	IL10, CXCL9, TGFB1, TNF, CCL3, CCL2
45	Cytokine-cytokine receptor interaction20	7.4	IL8, CCL2, CCL3, IFNG, TNF, TGFB1
46	Antioxidant Action of Vitamin-C36	7.3	IL2RA, IL3, IL5, IL8, CCL2, CCL3
47	MIF Mediated Glucocorticoid Regulation36	7.3	IL1B, IL18, IL10, IL2, IL3, IL5
48	all-trans-Retinoic Acid Signaling in Brain36	7.3	IL8, CCL2, CCL3, ALOX5, TNF, PTGES
49	p38 Signaling36	7.1	IL8, CCL2, CCL3, TGFB1, TP53, TNF
50	MIF Regulation of Innate Immune Cells36	6.8	TNF, TP53, CCL3, CCL2, IL8, IL5

Compounds related to pleurisy according to GeneDecks:

(show top 50)    (show all 335)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.5	TRB@, CXCL9
2	ionomycin32	10.0	IL5, IL3, GRP, CCL3
3	ivig32	9.7	PLA2G7, CRP, IL3
4	n acetylcysteine32	9.4	EPRS, TLR4, TP53, ALOX5, IL3, IL2RA
5	endotoxin32	9.1	CCL3, IL18, MEFV, CRP, PLA2G1B, EPRS
6	polyinosinic-polycytidylic acid32	9.0	TLR4, TLR2, IFNG, CCL3, IL8, IL5
7	rolipram32 42	10.0	PDE4A, IL10, ADA, KNG1, TNF, ALOX5
8	tarc32	8.8	IFNG, CCL3, CCL2, IL8, IL5, IL18
9	groalpha32	8.8	CCL3, CCL2, IL1B, IL18, IL17A, IL10
10	toxin-132	8.8	TNF, CCL3, CCL2, IL8, IL2, IL1RN
11	il-1232	8.7	TNF, IFNG, CCL2, IL8, IL5, IL2
12	poly(i-c)32	8.7	IFNG, CCL3, IL8, IL5, IL3, IL1B
13	sb 20358032 42	9.7	PLA2G6, CRP, TNF, ALOX5, IFNG, IL17A
14	lipoteichoic acid32	8.5	CCL3, CCL2, IL8, IL1RN, IL1B, IL18
15	sulfasalazine32 9 9	10.4	CRP, TNF, ALOX5, CCL2, IL2RA, IL1RN
16	polymyxin b32	8.4	IL10, IL1B, TLR4, TLR2, TNF, ICAM1
17	pge232	8.3	TLR2, PDE4A, GRP, IL17A, PLA2G7, PLA2G6
18	ccl332	8.3	TLR2, TNF, ICAM1, IFNG, CCL3, CCL2
19	pentoxifylline32 9 9	10.1	TNF, ICAM1, IFNG, IL8, IL2RA, IL2
20	h2o232	8.1	IL2RA, IL1RN, IL18, MPO, MUC16, PDE4A
21	infliximab32 9 9	9.9	TLR4, CRP, TNF, IFNG, IL2RA, IL1RN
22	rantes32	7.9	CXCL9, TGFB1, TLR4, TLR2, ICAM1, IFNG
23	triptolide32	7.9	IL2, IL1B, IL8, CCL2, PTGS2, TNF
24	hydrocortisone32 9 9	9.8	IL1RN, IL1B, IL10, GRP, VIM, PLA2G6
25	methacholine32 9 9	9.8	MPO, GRP, KNG1, TGFB1, CRP, ICAM1
26	leukotriene b432 42 18	9.7	PDE4A, MPO, TNF, ALOX5, CCL3, CCL2
27	fmlp32	7.6	ADA, TLR4, PLA2G1B, MPO, VIM, PDE4A
28	gm-csf32	7.5	TGFB1, TNF, IL10, IL18, IL1B, ICAM1
29	prostaglandin32	7.4	KNG1, TLR2, PLA2G6, PLA2G1B, PTGS2, PTGES
30	simvastatin32 34 42 9 18 9	12.4	IL18, IL10, IL1RN, IL8, TLR4, TLR2
31	prednisolone32 9 9	9.3	TNF, IFNG, CCL3, IL5, IL2RA, IL2
32	tacrolimus32 34 9 9	10.3	TGFB1, TLR4, TLR2, TNF, IL10, IL17A
33	aspirin32 34 18	9.3	CRP, PTGS2, ALOX5, IL2RA, IL1RN, IL18
34	neopterin32	7.1	CCL3, IL8, IL3, IL2RA, IL2, IL1RN
35	retinoic acid32 42 18	8.9	ALDH9A1, MPO, PDE4A, GRP, IL18, ICAM1
36	il 1032	6.8	TNF, IFNG, CCL3, CCL2, IL8, IL5
37	pdtc32	6.7	TP53, ICAM1, IFNG, CCL3, CCL2, IL8
38	creatinine32	6.7	ENO2, VIM, MUC16, IL3, IL2RA, IL1RN
39	prostacyclin32	6.7	KNG1, PLA2G7, PLA2G6, CRP, PTGS2, PDE4A
40	ly29400232	6.6	TGFB1, IL17A, IL10, IL18, IL1B, TLR4
41	genistein32 9 18 9	9.4	KNG1, TLR4, PLA2G6, PTGS2, TNF, ALOX5
42	thymidine32 18	7.1	IL2RA, IL2, IL1B, IL18, IL17A, IL10
43	cyclosporin a32 42	7.0	TLR2, PLA2G6, TNF, TRB@, ICAM1, IFNG
44	vegf32	5.9	ICAM1, CCL3, CCL2, ENO2, IL1RN, IL1B
45	lactate32	5.6	ADA, PSG2, TGFB1, TLR4, KRT19, PLA2G1B
46	indomethacin32 9 9	7.6	ADA, KNG1, TGFB1, PLA2G6, PLA2G1B, PTGS2
47	nitric oxide32 9 18 9	8.5	EPRS, KNG1, SLC11A1, CXCL9, PSG2, ENO2
48	actinomycin d32	5.0	KNG1, TGFB1, TLR4, TLR2, PLA2G6, PTGS2
49	serine32	4.9	KNG1, TGFB1, TLR4, TLR2, KLKB1, KRT19
50	cycloheximide32	3.2	KNG1, TGFB1, TLR4, TLR2, KRT19, PLA2G7

Cellular components related to pleurisy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	8.8	CXCL9, TLR4, TLR2, TNF, ICAM1, IFNG
2	extracellular region	GO:005576	5.8	CRP, PLA2G1B, PLA2G7, KLKB1, TGFB1, PSG2
3	extracellular space	GO:005615	4.3	MUC16, IFNG, ICAM1, TNF, CRP, PLA2G1B

Biological processes related to pleurisy according to GeneDecks:

(show top 50)    (show all 60)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to interferon-gamma	GO:071346	10.3	IL18, CCL2, CCL3
2	chronic inflammatory response to antigenic stimulus	GO:002439	10.3	IL1RN, IL1B
3	negative regulation of interleukin-17 production	GO:032700	10.3	TLR4, TLR2, IFNG
4	positive regulation of nitric-oxide synthase biosynthetic process	GO:051770	10.2	TLR4, TLR2, CCL2
5	cellular response to tumor necrosis factor	GO:071356	10.2	ICAM1, CCL3, CCL2, IL8, IL18
6	positive regulation of MHC class II biosynthetic process	GO:045348	10.1	TLR4, IFNG, IL10
7	positive regulation of tumor necrosis factor production	GO:032760	10.1	TLR4, TLR2, IFNG, CCL3, IL18
8	negative regulation of interleukin-12 production	GO:032695	10.1	TLR2, IL10, MEFV
9	cellular response to interleukin-1	GO:071347	10.1	ICAM1, CCL3, CCL2, IL8, IL17A
10	embryonic digestive tract development	GO:048566	10.0	ADA, TNF, IL8
11	neutrophil chemotaxis	GO:030593	10.0	PLA2G1B, IFNG, CCL3, CCL2, IL8, IL1B
12	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	10.0	TNF, IFNG, IL1B
13	positive regulation of interleukin-8 production	GO:032757	10.0	IL18, IL1B, TLR2, TLR4
14	positive regulation of vitamin D biosynthetic process	GO:060557	9.9	IFNG, TNF
15	positive regulation of osteoclast differentiation	GO:045672	9.9	TNF, IFNG, IL17A
16	positive regulation of chemokine biosynthetic process	GO:045080	9.9	TNF, IFNG, IL1B
17	positive regulation of B cell proliferation	GO:030890	9.9	ADA, TLR4, IL5, IL2
18	positive regulation of chemokine production	GO:032722	9.9	TLR4, TLR2, TNF, IL18
19	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.8	TNF, IFNG, IL1B
20	positive regulation of inflammatory response	GO:050729	9.8	TLR4, TLR2, PLA2G7, CCL3, IL2, IL18
21	positive regulation of interleukin-17 production	GO:032740	9.8	IL18, IL2, TGFB1
22	negative regulation of growth of symbiont in host	GO:044130	9.7	TLR2, TNF, IFNG, IL10
23	cellular response to lipopolysaccharide	GO:071222	9.7	TLR4, ICAM1, IFNG, CCL2, IL8, IL10
24	regulation of sensory perception of pain	GO:051930	9.7	CCL3, IL10, TLR4
25	response to activity	GO:014823	9.7	TLR4, TNF, CCL2, IL10
26	negative regulation of interleukin-6 production	GO:032715	9.6	TLR4, TNF, IL10
27	positive regulation of NF-kappaB import into nucleus	GO:042346	9.6	TLR4, TLR2, TNF, IL1B
28	positive regulation of interleukin-6 production	GO:032755	9.6	TLR4, TLR2, TNF, IL1B
29	positive regulation of fever generation	GO:031622	9.4	IL1B, TNF, PTGS2
30	protein kinase B signaling cascade	GO:043491	9.4	TGFB1, TNF, CCL3, CCL2, IL1B
31	positive regulation of interferon-gamma production	GO:032729	9.3	SLC11A1, TLR4, TNF, IL2, IL1B, IL18
32	cellular response to organic cyclic compound	GO:071407	9.3	TGFB1, TNF, CCL3, CCL2, IL1B, IL18
33	MAPK cascade	GO:000165	9.3	TGFB1, TNF, CCL3, CCL2, IL1B, IL18
34	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.3	TLR4, TP53, IL5, IL3
35	protein import into nucleus, translocation	GO:000060	9.2	SLC11A1, TGFB1, TNF, TP53, IFNG
36	positive regulation vascular endothelial growth factor production	GO:010575	9.0	TGFB1, PTGS2, IL1B
37	cell-cell signaling	GO:007267	9.0	CXCL9, CCL3, IL3, IL2, IL1B, IL18
38	anti-apoptosis	GO:006916	8.9	TNF, CCL2, IL2, IL1B, IL10, MPO
39	lipopolysaccharide-mediated signaling pathway	GO:031663	8.9	TGFB1, TLR4, TLR2, TNF, CCL3, CCL2
40	response to glucocorticoid stimulus	GO:051384	8.8	PTGS2, TNF, CCL2, IL1RN, IL1B, IL10
41	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.7	TGFB1, TLR4, TLR2, PLA2G1B, TNF, ICAM1
42	response to vitamin D	GO:033280	8.7	TGFB1, PTGS2, IL1B
43	positive regulation of nitric oxide biosynthetic process	GO:045429	8.7	TLR4, TLR2, PTGS2, TNF, ICAM1, IFNG
44	immune response	GO:006955	8.6	CXCL9, TLR4, TLR2, IL8, IL5, IL3
45	response to hypoxia	GO:001666	8.3	ADA, TGFB1, TLR4, CRP, TNF, CCL2
46	positive regulation of apoptotic process	GO:043065	8.2	KNG1, TLR4, PTGS2, TNF, TP53, IL1B
47	negative regulation of cell proliferation	GO:008285	7.9	TGFB1, PTGS2, PTGES, TNF, TP53, IL8
48	response to drug	GO:042493	7.9	TGFB1, PTGS2, TNF, ICAM1, IFNG, CCL2
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.6	SLC11A1, TGFB1, TLR4, TLR2, PLA2G1B, TNF
50	inflammatory response	GO:006954	5.9	MEFV, KNG1, SLC11A1, CXCL9, TGFB1, TLR2

Molecular functions related to pleurisy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	10.0	IL8, CCL2, CCL3, CXCL9
2	growth factor activity	GO:008083	8.1	TGFB1, IL5, IL3, IL2, IL1B, IL10
3	cytokine activity	GO:005125	7.8	IL10, CXCL9, TNF, IFNG, IL5, IL3