Aliases & Classifications for Pleurisy

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 27ICD9CM, 25ICD10
See all sources

Summaries for Pleurisy

About this section
Disease Ontology:8 A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs.

MalaCards based summary: Pleurisy, also known as pleurisy with pleural effusion, is related to mesothelioma and pneumonia. An important gene associated with Pleurisy is ADA (adenosine deaminase), and among its related pathways are Signaling by Interleukins and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds pentostatin and sodium stibogluconate have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and neutrophil, and related mouse phenotypes are hematopoietic system and mortality/aging.

Wikipedia:64 Pleurisy (also known as pleuritis) is an inflammation of the pleura, the lining surrounding the lungs.... more...

Related Diseases for Pleurisy

About this section

Diseases related to Pleurisy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1mesothelioma30.8ADA, PSG2
2pneumonia30.7PLA2G7, PSG2
3tuberculosis30.6IL2RA, IL18, IFNG, ADA
4peritonitis30.4ADA, MEFV
5arthritis30.2IL18, IFNG, MEFV
6pleural tuberculosis30.0ADA, PSG2, IFNG, IL18, IL2RA
7leukemia30.0ADA, PSG2, IFNG, IL2RA
8pulmonary sarcoidosis29.9IL2RA, IL18, IFNG
9pulmonary tuberculosis29.8ADA, IFNG, IL18, IL2RA
10eosinophilia29.8IFNG, IL18, IL2RA
11rheumatoid arthritis29.7ADA, MEFV, IFNG, IL18, IL2RA
12systemic lupus erythematosus29.5PLA2G7, IL2RA, IL18, IFNG, ADA
13periapical granuloma10.4IL2RA
14lung cancer10.4
15brucellosis10.4MEFV
16malaria10.4IFNG
17pertussis10.4
18pericardial effusion10.3ADA, PSG2
19severe combined immunodeficiency, x-linked10.3IL2RA, ADA
20hcl-v10.3IL2RA, ADA
21mycosis fungoides10.2ADA, IL2RA
22lupus erythematosus10.2
23hemophagocytic lymphohistiocytosis10.2IL18, IL2RA
24chronic granulomatous disease10.2IFNG, ADA
25cinca syndrome10.2IL18, MEFV
26tuberculoid leprosy10.2IL2RA, IFNG
27breast cancer10.2
28blindness10.2
29tropical spastic paraparesis10.2IL2RA, IFNG
30lupus nephritis10.2IL2RA, IL18
31acute pancreatitis10.2IL18, PSG2
32sezary's disease10.2IFNG, IL2RA
33factor vii deficiency10.2PSG2, IFNG
34atopy10.2IL18, IFNG
35plasmodium falciparum malaria10.1IFNG, IL18
36hashimoto thyroiditis10.1IL2RA, IFNG
37uveitis10.1IFNG, IL2RA
38hypercholesterolemia, familial10.1PLA2G7, ADA
39pericarditis10.1ADA, PSG2, MEFV
40hematologic cancer10.1IL2RA, ADA
41hypersensitivity reaction type ii disease10.1IL2RA, IL18
42bacteremia10.1
43pleuropneumonia10.1
44pneumothorax10.1
45tetanus10.1IL2RA, IFNG
46pulmonary fibrosis, idiopathic10.1IL18, IFNG
47juvenile rheumatoid arthritis10.1PLA2G7, IL2RA
48dermatitis10.1IL18, IFNG
49cutaneous t cell lymphoma10.0IL2RA, IFNG, ADA
50severe combined immunodeficiency10.0ADA, IFNG, IL2RA

Graphical network of the top 20 diseases related to Pleurisy:



Diseases related to pleurisy

Symptoms for Pleurisy

About this section

Drugs & Therapeutics for Pleurisy

About this section

Drug clinical trials:

Search ClinicalTrials for Pleurisy

Search NIH Clinical Center for Pleurisy

Genetic Tests for Pleurisy

About this section

Anatomical Context for Pleurisy

About this section

MalaCards organs/tissues related to Pleurisy:

31
Lung, T cells, Neutrophil, Testes, Nk cells, Breast, Monocytes, Heart, Skin

Animal Models for Pleurisy or affiliated genes

About this section

MGI Mouse Phenotypes related to Pleurisy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0IL2RA, IL18, IFNG, MEFV, ADA
2MP:00107688.0IL2RA, IL18, IFNG, MEFV, ADA
3MP:00053877.9ADA, MEFV, IFNG, IL18, IL2RA
4MP:00053787.7ADA, MEFV, IFNG, IL18, IL2RA

Publications for Pleurisy

About this section

Articles related to Pleurisy:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Polygala molluginifolia A. St.-Hil. and Moq. prevent inflammation in the mouse pleurisy model by inhibiting NF-I_B activation. (24560858)
2014
2
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) preceding tuberculous pleurisy. (24576282)
2014
3
Mycobacterium intracellulare Pleurisy Identified on Liquid Cultures of the Pleural Fluid and Pleural Biopsy. (23579554)
2013
4
PD-1/PD-Ls pathways between CD4(+) T cells and pleural mesothelial cells in human tuberculous pleurisy. (24406080)
2013
5
Combined NMR and GC-MS Analyses Revealed Dynamic Metabolic Changes Associated with the Carrageenan-Induced Rat Pleurisy. (24131325)
2013
6
Lung squamous cell carcinoma combined with tuberculous pleurisy. (23075740)
2012
7
Factors associated with pleurisy in pigs: a case-control analysis of slaughter pig data for England and Wales. (22363407)
2012
8
Carcinomatosis lymphangitis and pleurisy after allo-SCT in two patients with secondary leukemia after breast cancer. (21383684)
2012
9
Mantle cell lymphoma involvement of the pleura and tuberculous pleurisy with pulmonary tuberculosis: a case report and literature review. (21968964)
2012
10
Diagnostic accuracy of T-cell interferon-I^ release assays in tuberculous pleurisy: a meta-analysis. (21299686)
2011
11
Serum trace element levels in tuberculous pleurisy. (20461473)
2011
12
Non-tuberculous mycobacterial pleurisy: an 8-year single-centre experience in Taiwan. (20392359)
2010
13
Evidence of anti-inflammatory effects of pioglitazone in the murine pleurisy model induced by carrageenan. (19716439)
2009
14
Tuberculous pleurisy after tumour necrosis factor-alpha antagonist usage: case report]. (19123083)
2008
15
Corticosteroids for tuberculous pleurisy. (17943759)
2007
16
Antiinflammatory effects of Tacrolimus in a mouse model of pleurisy. (16860713)
2006
17
Pneumocystis carinii pneumonia with pleurisy, platypnoea and orthodeoxia. (12554907)
2003
18
Positive response to oral chemoendocrine combination therapy using 5"-deoxy-5-fluorouridine for locally advanced breast cancer with carcinomatous pleurisy: report of a case. (14669082)
2003
19
Diagnostic tools in tuberculous pleurisy: a direct comparative study. (14582908)
2003
20
Evaluation of suspected tuberculous pleurisy: clinical and diagnostic findings in HIV-1-positive and HIV-negative adults in Uganda. (11495266)
2001
21
Elevated soluble CD26 levels in patients with tuberculous pleurisy. (11573900)
2001
22
Hypoxemia modifies circulating and exudate neutrophil number and functional responses in carrageenin-induced pleurisy in the rat. (10857850)
2000
23
Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice. (10403502)
1999
24
Regulation of prostaglandin production in carrageenan-induced pleurisy by melatonin. (10451019)
1999
25
Relationship between nitric oxide and prostaglandins in carrageenin pleurisy. (9605435)
1998
26
Tuberculous pleurisy is more common in AIDS than in non-AIDS patients with tuberculosis. (9266874)
1997
27
Adenosine deaminase (ADA) isoenzyme analysis in pleural effusions: diagnostic role, and relevance to the origin of increased ADA in tuberculous pleurisy. (8726940)
1996
28
Use of adenosine deaminase as a diagnostic tool for tuberculous pleurisy. (7638812)
1995
29
Anti-inflammatory effect of magnolol, isolated from Magnolia officinalis, on A23187-induced pleurisy in mice. (8583356)
1995
30
Involvement of leukotriene B4 in zymosan-induced rat pleurisy: inhibition of leukocyte infiltration by the 5-lipoxygenase inhibitor T-0757. (8845830)
1995
31
Tuberculous pleurisy after percutaneous needle biopsy of a pulmonary nodule. (7938803)
1994
32
Antiinflammatory action of thielocin A1 beta, a group II phospholipase A2 specific inhibitor, in rat carrageenan-induced pleurisy. (8491510)
1993
33
Effect of treatment with interleukin-1 receptor antagonist on the development of carrageenan-induced pleurisy in the rat. (8491511)
1993
34
Adenosine deaminase activity and isozyme test for differentiation diagnosis of tuberculous pleurisy]. (7923429)
1993
35
Suppression by cetirizine of pleurisy triggered by antigen in actively sensitized rats. (1362160)
1992
36
Adenosine deaminase in rheumatoid pleurisy. (2035103)
1991
37
Anti-inflammatory effects of cyclosporin A (CsA) in carragheenan-induced pleurisy in rats. (2158217)
1990
38
The usefulness and limitations of adenosine deaminase in the diagnosis of tubercular pleurisy. A meta-analytical study]. (2149157)
1990
39
Change of glycosaminoglycan in pus of patients with purulent pleurisy. (2719860)
1989
40
Prevalence of pleurisy in pigs at slaughter. (3218056)
1988
41
Induction of lymphokine-activated killer cells by intrapleural instillations of recombinant interleukin-2 in patients with malignant pleurisy due to lung cancer. (3493843)
1987
42
The anti-inflammatory mechanism of MK-447 in rat carrageenin-induced pleurisy. (6635213)
1983
43
Low in vitro response to PPD and PHA in lymphocytes from BCG-induced pleurisy in guinea pigs. (7140874)
1982
44
The reduction of tuberculin-induced pleurisy in the guinea-pig by a gold salt, chloroquine and D-penicillamine. (6115933)
1981
45
Influence of some irritating or immunostimulating substances on experimental pleurisy in the rat. (7406599)
1980
46
Action of various drugs with anti-inflammatory or anti-rheumatic properties on pleurisy due to Bordetella pertussis hypersensitivity in the rat. (232922)
1979
47
Sequelae of pleurisy]. (209523)
1978
48
Immunology of lymphocytes in pleurisy and in effusions due to pleural infiltration by chronic lymphocytic leukemia cells. (310227)
1978
49
Radiological case of the month: Tuberculous pleurisy with spinal dissemination. (875474)
1977
50
Meigs' syndrome and pathogenesis of pleurisy and polyserositis. (13760748)
1960

Variations for Pleurisy

About this section

Expression for genes affiliated with Pleurisy

About this section
Search GEO for disease gene expression data for Pleurisy.

Pathways for genes affiliated with Pleurisy

About this section

Pathways related to Pleurisy according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5IL2RA, IL18
2
Show member pathways
9.4MEFV, IL18
3
Show member pathways
IL-2 Signaling pathway36
9.4IL2RA, IFNG
4
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.4IL2RA, IFNG
5
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.4IFNG, IL2RA
69.4IL2RA, IFNG
79.4IL2RA, IFNG
8
Show member pathways
9.4IFNG, IL2RA
99.3IL18, IFNG
109.3IL18, IFNG
119.3IL18, IFNG
12
Show member pathways
9.3IL18, IFNG
139.3IFNG, IL18
14
Show member pathways
IL27-mediated signaling events36
9.3IFNG, IL18
159.3IFNG, IL18
169.3IFNG, IL18
178.9IL2RA, IL18, IFNG
18
Show member pathways
Immune response IL 12 induced IFN gamma production59
8.9IL2RA, IL18, IFNG
19
Show member pathways
8.9IL2RA, IL18, IFNG
20
Show member pathways
8.9IL2RA, IL18, IFNG
21
Show member pathways
8.9IL2RA, IL18, IFNG
22
Show member pathways
8.9IFNG, IL18, IL2RA
23
Show member pathways
8.9IFNG, IL18, IL2RA
24
Show member pathways
8.7PLA2G7, IL2RA, IL18

Compounds for genes affiliated with Pleurisy

About this section

Compounds related to Pleurisy according to GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1pentostatin44 60 28 1113.0IL2RA, ADA
2sodium stibogluconate44 1110.8ADA, IFNG
3gluten449.8IL18, IL2RA
4amphotericin b449.7ADA, IFNG
5levamisole44 1110.7IL2RA, IL18
6gold sodium thiomalate449.7IFNG, IL2RA
7pirfenidone44 6010.7IFNG, IL2RA
8ranitidine44 28 24 1112.6ADA, IL18, IL2RA
9il-12449.5IL18, IFNG
102,5-oligoadenylate449.5ADA, IFNG, IL2RA
11indoleamine449.4IFNG, IL18
12methotrexate50 44 1111.4IL18, IL2RA, ADA
13ribavirin44 50 1111.4IL18, ADA, IFNG
14imiquimod44 60 28 1112.3IFNG, IL18
15natalizumab44 1110.3IFNG, IL18, IL2RA
16con a449.3IFNG, IL18, IL2RA
17epinephrine44 24 1111.3IL2RA, IL18, ADA
18il 10449.3IL2RA, IFNG, IL18
19mycophenolate mofetil44 50 1111.3IFNG, IL18, IL2RA
20infliximab44 50 1111.3IFNG, IL18, IL2RA
21pentoxifylline44 1110.3IL18, IFNG, IL2RA
22ifn-alpha449.3IL2RA, IL18, IFNG
23thalidomide44 50 60 1112.3IL2RA, IL18, IFNG
24prednisolone44 28 1111.2IL2RA, IL18, IFNG
25ionomycin449.2IFNG, IL18, IL2RA
26tacrolimus44 50 1111.2IL2RA, IL18, IFNG
27acetylcholine44 50 28 24 1113.1IL18, ADA, IL2RA
28doxorubicin44 50 1111.1IL2RA, PSG2, IL18, ADA
29creatinine449.1ADA, PSG2, IL18, IL2RA
30p002449.1PLA2G7, IL18, PSG2
31rantes449.1IFNG, IL2RA, IL18
32atorvastatin44 50 28 24 1113.0PLA2G7, IL2RA, IL18
33ivig449.0PLA2G7, IFNG, IL2RA
34tuberculin449.0IL2RA, IFNG, IL18, ADA
35neopterin449.0IL2RA, IL18, IFNG, ADA
36indomethacin44 28 60 1111.9IL2RA, ADA, IL18, IFNG
37histamine44 28 2410.9ADA, IFNG, IL18, IL2RA
385fluorouracil448.9IL2RA, PSG2, IL18, IFNG
39cyclosporin a44 28 6010.9IFNG, IL18, IL2RA, ADA
40thymidine44 249.8IL18, IL2RA, IFNG, PSG2
41norepinephrine44 24 1110.8ADA, IL2RA, IL18
42arginine448.8ADA, IFNG, IL18, IL2RA
43aspirin44 50 28 2411.7ADA, IL18, PLA2G7, IL2RA
44vegf448.5PSG2, IL2RA, IL18, IFNG, ADA
45pge2448.4IFNG, IL2RA, PLA2G7, IL18
46endotoxin448.4IFNG, MEFV, IL18, PLA2G7
47cysteine448.4IL2RA, IL18, IFNG, ADA
48nitric oxide44 24 1110.4PSG2, PLA2G7, IFNG, IL18
49estrogen448.4PLA2G7, IL18, IL2RA, ADA
50dexamethasone44 50 28 1111.1IL2RA, IL18, PLA2G7, ADA, IFNG

GO Terms for genes affiliated with Pleurisy

About this section

Cellular components related to Pleurisy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.7IL2RA, IFNG, ADA
2extracellular regionGO:00055768.1PLA2G7, IL18, IFNG, PSG2

Biological processes related to Pleurisy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of activated T cell proliferationGO:00421049.2IL2RA, IL18
2positive regulation of inflammatory responseGO:00507299.1PLA2G7, IL18
3negative regulation of inflammatory responseGO:00507289.0IL2RA, MEFV, ADA

Sources for Pleurisy

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet