MCID: PLR008
MIFTS: 46

Pleurisy malady

Summaries for Pleurisy

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. the inflamed pleural layers rub against each other every time the lungs expand to breathe in air. this can cause sharp pain with breathing (also called pleuritic chest pain).

MalaCards: Pleurisy is related to tuberculosis and pleural tuberculosis. An important gene associated with Pleurisy is ADA (adenosine deaminase), and among its related pathways are Malaria and Rheumatoid arthritis. The compounds gm-csf and pge2 have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and hematopoietic system.

Wikipedia:64 Pleurisy (also known as pleuritis) is an inflammation of the pleura, the lining surrounding the lungs.... more...

Aliases & Classifications for Pleurisy

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 25ICD10
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Related Diseases for Pleurisy

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pleurisy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.9CCL3, IFNG, CXCL9, IL2RA, IL18, CEACAM7
2pleural tuberculosis30.7ADA, CEACAM7, IL8, IL18, IL2RA, PSG2
3systemic lupus erythematosus30.3CCL2, CCL3, IFNG, TRB, IL2RA, IL18
4arthritis30.3CCL2, CCL3, IFNG, MEFV, TRB, CXCL9
5pulmonary tuberculosis30.1CCL3, IFNG, MUC16, IL2RA, IL18, ADA
6familial mediterranean fever29.9MEFV
7synovitis29.9IL8, IL18
8oral cancer29.9ALOX5
9septic shock29.9PLA2G1B, PLA2G6, PLA2G7, IL8
10pulmonary sarcoidosis29.9IL18, IL2RA, CXCL9, TRB, IFNG, CCL3
11ulcerative colitis29.9IFNG, PDE4A, IL2RA, IL18, IL8, PLA2G7
12tuberculous pneumothorax10.1
13acute myocardial infarction10.0MEFV
14rhinitis10.0IL8
15lupus erythematosus10.0IL18
16extrapulmonary tuberculosis10.0ADA
17liver cirrhosis10.0ADA
18multiple myeloma10.0CCL3
19sarcoma10.0ADA
20urticaria10.0ALOX5
21alopecia areata10.0IFNG
22leishmaniasis10.0IFNG
23human immunodeficiency virus infectious disease10.0CCL3
24bladder carcinoma10.0PSG2
25hypercholesterolemia10.0PLA2G7
26hepatitis10.0IL18
27keratitis10.0CXCL9
28polymyositis10.0CCL3
29vascular disease10.0IL8
30myasthenia gravis10.0IFNG
31nephrotic syndrome10.0IL2RA, PLA2G7
32brucellosis10.0MEFV
33arthropathy10.0ALOX5
34myeloid leukemia10.0TRB
35deficiency anemia10.0MUC16
36meningitis10.0ADA, IL8
37chagas disease10.0TRB
38hypertension10.0CCL2
39celiac disease10.0TRB
40primary pulmonary hypertension10.0ALOX5
41diphtheria10.0IL2RA
42cholera10.0PDE4A
43atopy10.0IL18, IFNG
44primary hyperoxaluria10.0CCL2
45lichen planus10.0CXCL9
46bronchiolitis10.0IL8, CCL3
47herpes simplex10.0TRB, PSG2
48adenoma10.0CEACAM7, PSG2
49dermatomyositis10.0CCL3, MUC16
50candidiasis10.0IFNG

Graphical network of the top 20 diseases related to Pleurisy:



Diseases related to pleurisy

Clinical Features for Pleurisy

Drugs & Therapeutics for Pleurisy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Pleurisy

Drug clinical trials:

Search ClinicalTrials for Pleurisy

Search NIH Clinical Center for Pleurisy

Search CenterWatch for Pleurisy

Genetic Tests for Pleurisy

Anatomical Context for Pleurisy

Animal Models for Pleurisy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Pleurisy

Sources:
51PubMed
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Articles related to Pleurisy:

(show top 50)    (show all 522)
idTitleAuthorsYear
1
Factors associated with pleurisy in pigs: a case-control analysis of slaughter pig data for England and Wales. (22363407)
2012
2
Amplified Mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy--a diagnostic accuracy study. (22970318)
2012
3
Neutrophil recruitment is inhibited by nicotinamide in experimental pleurisy in mice. (22543086)
2012
4
Lactoferrin restrains allergen-induced pleurisy in mice. (22810368)
2012
5
Clinical value of ELISA-MPT64 for the diagnosis of tuberculous pleurisy. (22674175)
2012
6
CXCL12 as a biological marker for the diagnosis of tuberculous pleurisy. (22297026)
2012
7
The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy. (21411195)
2011
8
Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy. (21829471)
2011
9
Use of a subcutaneous implantable pleural port in the management of recurrent malignant pleurisy: five-year experience based on 168 subcutaneous implantable pleural ports. (21612501)
2011
10
NK cells from tuberculous pleurisy express high ICAM-1 levels and exert stimulatory effect on local T cells. (19714575)
2009
11
Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy. (17158890)
2007
12
Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy. (17686594)
2007
13
Passiflora alata and Passiflora edulis spray-dried aqueous extracts inhibit inflammation in mouse model of pleurisy. (17215089)
2007
14
Resolution of residual pleural disease according to time course in tuberculous pleurisy during and after the termination of antituberculosis medication. (16304268)
2005
15
Clinical investigation on diagnostic value of interferon-gamma, interleukin-12 and adenosine deaminase isoenzyme for tuberculous pleurisy. (15740654)
2005
16
Comparison between C57Bl/6 and C57Bl/10 mycobacterial mouse pleurisy with respect to cellular migration and nitric oxide production. (15901414)
2004
17
Concurrent evolution and resolution in an acute inflammatory model of rat carrageenin-induced pleurisy. (12660220)
2003
18
Nitric oxide inhibits leucocyte migration in carrageenin-induced rat pleurisy. (11028758)
2000
19
Pleurisy: diagnostic and therapeutic management]. (10793945)
2000
20
Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice. (10403502)
1999
21
Tuberculous pleurisy with effusion. (10575837)
1999
22
Relationship between nitric oxide and prostaglandins in carrageenin pleurisy. (9605435)
1998
23
Mycobacterium-mediated chemokine expression in pleural mesothelial cells: role of C-C chemokines in tuberculous pleurisy. (9780267)
1998
24
Procoagulant activity of purified protein derivative-stimulated pleural effusion mononuclear cells in tuberculous pleurisy. (9097351)
1997
25
Effects of nimesulide, a preferential cyclooxygenase-2 inhibitor, on carrageenan-induced pleurisy and stress-induced gastric lesions in rats. (9014217)
1996
26
Tuberculous pleurisy after percutaneous needle biopsy of a pulmonary nodule. (7938803)
1994
27
Calcium pyrophosphate-induced pleurisy in rats: a new model of acute inflammation. 1975. (7725977)
1994
28
Antiinflammatory action of thielocin A1 beta, a group II phospholipase A2 specific inhibitor, in rat carrageenan-induced pleurisy. (8491510)
1993
29
Role of PAF in the allergic pleurisy caused by ovalbumin in actively sensitized rats. (8381149)
1993
30
Quinacrine-induced pleural inflammation in malignant pleurisy: relation between drainage time of pleural fluid and local interleukin-1 beta levels. (8290803)
1993
31
Cell-associated and soluble phospholipases A2 increase during carrageenan and zymosan-induced pleurisy in rat. (8339752)
1993
32
Homologous tachyphylaxis to bradykinin and its interference with allergic pleurisy in actively sensitized rats. (1425980)
1992
33
Diagnostic value of adenosine deaminase and lysozyme in tuberculous pleurisy. (1395040)
1992
34
The usefulness of pleural biopsy in benign or malignant pleurisy]. (2067153)
1991
35
Effect of capsaicin on carrageenan-induced inflammation in rat pleurisy and exudate substance P level. (1724349)
1991
36
Phospholipase A2 acyl-hydrolytic activity in rat RPAR-induced pleurisy. (1838900)
1991
37
Characterization of phospholipase A2 activity in rat RPAR-induced pleurisy. (1838901)
1991
38
Inhibition of rat paw oedema and pleurisy by the extract from Mandevilla velutina. (1719783)
1991
39
Soluble interleukin-2 receptor in the serum and the pleural fluid in patients with tuberculous pleurisy]. (2281539)
1990
40
Adenosine deaminase activity, not diagnostic for tuberculous pleurisy. (3653300)
1987
41
A rare cause of pleurisy. (3732434)
1986
42
A comparison of air pouch, sponge and pleurisy models of acute carrageenan inflammation in the rat. (3463171)
1986
43
Unilateral chest wall edema in carcinomatous pleurisy. (3975496)
1985
44
Rat pleurisy induced by kaolin or croton oil: time course of fluid accumulation and white cell migration. (4055263)
1985
45
Acute rheumatoid pleurisy with effusion and demonstration of a rheumatoid nodule in the pleura. (6500107)
1984
46
Contralateral pleural effusion during chemotherapy for tuberculous pleurisy. (6485118)
1984
47
Low in vitro response to PPD and PHA in lymphocytes from BCG-induced pleurisy in guinea pigs. (7140874)
1982
48
Intrapleural therapy of malignant pleurisy in patients with neuroblastoma. (7266428)
1981
49
A possible role of prostaglandins and bradykinin as a trigger of exudation in carrageenin-induced rat pleurisy. (636934)
1978
50
Action of chloroquine on pleurisy due to Bordetella pertussis hypersensitivity. (29110)
1978

Genetic Variations for Pleurisy

Expression for genes affiliated with Pleurisy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleurisy

Search GEO for disease gene expression data for Pleurisy.

Pathways for genes affiliated with Pleurisy

Sources:
30KEGG, 52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore
See all sources

Pathways related to Pleurisy according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL18
210.4IL18
3
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10.3CCL2, IL2RA
4
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10.3CCL2, IL8
510.3PLA2G6, CCL2
610.2IFNG, IL2RA, IL18
7
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10.2IFNG, IL8, IL2RA
810.2IFNG, IL18, IL8
910.2IL18, IFNG, CCL2
10
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10.2CCL3, IL2RA, IFNG
1110.2CCL2, ALOX5, IFNG
12
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10.2PLA2G1B, PLA2G7, PLA2G6
13
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10.2ALOX5, PLA2G1B, PLA2G6
14
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10.1IL8, IL18, MEFV, CCL2
1510.1CCL3, IFNG, IL18, IL8
16
Development PDGF signaling via STATs and NF-kB
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10.1CXCL9, IL18, IFNG, CCL2
1710.1IL8, CXCL9, CCL2, CCL3
18
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10.0CCL2, IL8, IL18, IL2RA, IFNG
19
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10.0IL2RA, TRB, IFNG, CCL3, IL18
20
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10.0IL8, IFNG, CCL3, CCL2, CXCL9
21
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9.9PLA2G1B, PLA2G6, IL2RA, CXCL9, CCL3
22
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9.9IL2RA, IL18, CCL3, IL8, CCL2, CXCL9
23
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9.9CXCL9, CCL3, IL2RA, PLA2G7, PLA2G6, PLA2G1B
24
Hide members
9.7PLA2G1B, PLA2G6, CCL3, PLA2G7, IL8, CXCL9

Compounds for genes affiliated with Pleurisy

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB
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Compounds related to Pleurisy according to GeneCards/GeneDecks:

(show top 50)    (show all 171)
idCompoundScoreTop Affiliating Genes
1gm-csf45 2911.8IFNG
2pge24510.7PLA2G7, PDE4A
3endotoxin4510.6MEFV, PLA2G1B, PLA2G7
4pentoxifylline45 1111.6IL18, PDE4A
5rantes4510.6IL2RA, IFNG, CCL3
6indomethacin45 60 29 1113.6PLA2G6, PLA2G1B, ALOX5
7rolipram45 60 2912.6ADA, ALOX5, PDE4A
8tuberculin4510.5IFNG, ADA, IL2RA, IL18
9pdtc4510.5IL8, IL18, CCL2
10prednisolone45 29 1112.5MUC16, IL2RA
11aspartate4510.5CCL2, PDE4A, ALOX5, ADA
12cyclophosphamide45 50 1112.4TRB, IL2RA, CXCL9, MUC16
13il-124510.4IL18, IFNG, IL8, CCL2
14lysophospholipid4510.4CCL2, PLA2G7, PLA2G6, PLA2G1B
155 aminosalicylic acid4510.4ALOX5, IL8, IL2RA, CCL2
16cycloheximide4510.4IL18, CEACAM7, PLA2G6, PLA2G7, PDE4A
17scalaradial4510.4PLA2G6, ALOX5, PLA2G1B
18creatinine4510.4ADA, MUC16, PSG2, LCN1, CXCL9
19groalpha4510.4CCL3, IL8, IL18, CCL2, CXCL9
20neopterin4510.4CCL3, IFNG, IL2RA, IL18, IL8, ADA
21phosphatidylcholine4510.4ALOX5, CCL2, PLA2G1B, PLA2G7
22fmlp4510.4ALOX5, PDE4A, CCL3, ADA, PLA2G1B
23triptolide4510.3IL8, IFNG, CCL3, CCL2
24sulfasalazine45 29 50 1113.3IL8, CCL2, IL2RA, ALOX5
25lipoteichoic acid4510.3IL18, IL8, CCL2, CCL3
26tarc4510.3CXCL9, CCL3, IL8, IFNG, IL18, CCL2
27ccl345 2911.3IL8, CCL3, CCL2, IL18, IFNG, CXCL9
28manoalide4510.3PLA2G1B, PLA2G6, ALOX5
29il 104510.3CCL3, IL8, IFNG, CXCL9, IL2RA, IL18
30aspirin45 50 29 2413.2PLA2G7, PLA2G6, ALOX5, PDE4A, IL2RA, ADA
31lysophosphatidylcholine45 2911.2CCL2, PLA2G7, CXCL9, PLA2G6
325fluorouracil4510.2IL18, IL2RA, PSG2, IFNG, CCL3, CCL2
33sb 20358045 6011.2IL18, CCL3, IFNG, IL8, PLA2G6, ALOX5
34leukotriene b445 60 2412.2CCL3, ALOX5, PLA2G1B, PLA2G7, IL8, CCL2
35polyinosinic-polycytidylic acid4510.2IL8, IL18, IFNG, CCL3
36epinephrine45 11 2412.2PDE4A, CCL3, ALOX5, ADA, IL2RA, IL18
37h2o24510.2CCL3, MUC16, IL2RA, IL18, PLA2G1B, ALOX5
38oxygen45 2411.1CCL3, CCL2, PDE4A, PLA2G1B, IL8, PLA2G7
39actinomycin d4510.1IL8, PLA2G6, PDE4A, IFNG, CCL3, CEACAM7
40dexamethasone45 50 29 1113.1MUC16, PDE4A, CXCL9, ADA, ALOX5, PLA2G1B
41ndga4510.1PLA2G6, IL2RA, ALOX5, PLA2G1B
42txb24510.1PLA2G7, PLA2G6, PLA2G1B, ALOX5
43lactate4510.1ADA, PLA2G1B, IL8, IL18, MUC16, PSG2
44p-bromophenacyl bromide4510.1ALOX5, PLA2G1B, PLA2G6
45cyclosporin a45 29 6012.0TRB, PLA2G6, CCL3, IFNG, IL2RA, IL18
46arginine4510.0PLA2G6, CXCL9, IFNG, IL2RA, IL18, PDE4A
47nitric oxide45 11 2411.9CCL3, PLA2G7, CCL2, IL8, PSG2, PDE4A
48histamine45 29 2411.9IL8, IL18, IL2RA, IFNG, PDE4A, CXCL9
49poly(i-c)459.8CCL3, IL8, IFNG, IL18
50vegf459.8CCL2, ADA, ALOX5, IL8, IL18, IL2RA

GO Terms for genes affiliated with Pleurisy

Sources:
16Gene Ontology
See all sources

Cellular components related to Pleurisy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.1ADA, IL2RA, CXCL9, IFNG
2extracellular spaceGO:0056159.5PLA2G1B, IL8, IL18, CXCL9, MUC16, IFNG
3extracellular regionGO:0055769.2PLA2G1B, LCN1, PLA2G7, IL8, IL18, CXCL9

Biological processes related to Pleurisy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interferon-gammaGO:07134610.5IL18, CCL3, CCL2
2lipopolysaccharide-mediated signaling pathwayGO:03166310.4IL18, CCL3, CCL2
3cellular response to organic cyclic compoundGO:07140710.4CCL3, IL18, CCL2
4astrocyte cell migrationGO:04361510.4CCL2, CCL3
5cellular response to interleukin-1GO:07134710.4IL8, CCL3, CCL2
6positive regulation of tumor necrosis factor productionGO:03276010.4IFNG, CCL3, IL18
7cellular response to tumor necrosis factorGO:07135610.4IL8, IL18, CCL3, CCL2
8positive regulation of inflammatory responseGO:05072910.4CCL3, PLA2G7, IL18
9negative regulation of inflammatory responseGO:05072810.4IL2RA, MEFV, ADA
10chemotaxisGO:00693510.3CCL2, CCL3, PLA2G6, CXCL9
11neutrophil chemotaxisGO:03059310.3PLA2G1B, CCL2, CCL3, IFNG, IL8
12lymphocyte chemotaxisGO:04824710.3CCL3, CCL2
13macrophage chemotaxisGO:04824610.3CCL2, CCL3
14MAPK cascadeGO:00016510.2IL18, CCL2, CCL3
15inflammatory responseGO:00695410.2MEFV, CXCL9, IL18, IL8, CCL2, CCL3
16cellular response to lipopolysaccharideGO:07122210.1IFNG, IL8, CCL2
17endoplasmic reticulum unfolded protein responseGO:0309689.9CCL2, IFNG, IL8

Molecular functions related to Pleurisy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent phospholipase A2 activityGO:04749910.3PLA2G6, PLA2G7
2chemokine activityGO:0080099.8IL8, CXCL9, CCL3, CCL2

Products for genes affiliated with Pleurisy

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Sources for Pleurisy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet