MCID: PLR008
MIFTS: 47

Pleurisy malady

Respiratory diseases category
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Summaries for Pleurisy

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs.

MalaCards: Pleurisy is related to tuberculosis and pneumonia. An important gene associated with Pleurisy is ADA (adenosine deaminase), and among its related pathways are Signaling by Interleukins and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds pentostatin and sodium stibogluconate have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related mouse phenotypes are hematopoietic system and mortality/aging.

Wikipedia:65 Pleurisy (also known as pleuritis) is an inflammation of the pleura, the lining surrounding the lungs.... more...

Aliases & Classifications for Pleurisy

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 25ICD10
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Related Diseases for Pleurisy

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17GeneCards, 18GeneDecks
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Diseases related to Pleurisy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.8IL2RA, ADA, IFNG, IL18
2pneumonia30.6PLA2G7, PSG2
3sarcoidosis30.3IFNG, ADA, IL18, IL2RA
4pleural tuberculosis30.3IFNG, IL2RA, IL18, PSG2, ADA
5arthritis30.3MEFV, IFNG, IL18
6rheumatoid arthritis30.2MEFV, IFNG, IL18, IL2RA, ADA
7peritonitis30.2ADA, MEFV
8systemic lupus erythematosus30.0ADA, IL18, IFNG, PLA2G7, IL2RA
9pulmonary tuberculosis30.0IL18, ADA, IL2RA, IFNG
10leukemia30.0PSG2, ADA, IL2RA, IFNG
11pulmonary sarcoidosis29.9IL2RA, IL18, IFNG
12eosinophilia29.9IL2RA, IL18, IFNG
13ulcerative colitis29.7IL2RA, IFNG, IL18, PLA2G7
14lung cancer10.4
15pertussis10.3
16breast cancer10.2
17lupus erythematosus10.2
18malignant mesothelioma10.2
19blindness10.2
20periapical granuloma10.1IL2RA
21brucellosis10.1MEFV
22malaria10.1IFNG
23pneumothorax10.1
24pericardial effusion10.1ADA, PSG2
25gamma chain deficiency10.1IL2RA, ADA
26hairy cell leukemia10.1ADA, IL2RA
27mycosis fungoides10.1ADA, IL2RA
28hemophagocytic lymphohistiocytosis10.1IL2RA, IL18
29benign mesothelioma10.1ADA, PSG2
30chronic granulomatous disease10.0IFNG, ADA
31chronic infantile neurological cutaneous articular syndrome10.0IL18, MEFV
32tuberculoid leprosy10.0IFNG, IL2RA
33tropical spastic paraparesis10.0IFNG, IL2RA
34lupus nephritis10.0IL18, IL2RA
35sezary's disease10.0IL2RA, IFNG
36acute pancreatitis10.0PSG2, IL18
37factor vii deficiency10.0PSG2, IFNG
38atopy10.0IFNG, IL18
39plasmodium falciparum malaria10.0IL18, IFNG
40autoimmune thyroiditis10.0IL2RA, IFNG
41uveitis10.0IL2RA, IFNG
42familial hypercholesterolemia10.0PLA2G7, ADA
43pericarditis10.0ADA, MEFV, PSG2
44hematologic cancer10.0ADA, IL2RA
45hypersensitivity reaction type ii disease10.0IL18, IL2RA
46juvenile rheumatoid arthritis10.0PLA2G7, IL2RA
47idiopathic pulmonary fibrosis10.0IFNG, IL18
48tetanus10.0IFNG, IL2RA
49dermatitis10.0IL18, IFNG
50cutaneous t cell lymphoma10.0ADA, IFNG, IL2RA

Graphical network of the top 20 diseases related to Pleurisy:



Diseases related to pleurisy

Symptoms for Pleurisy

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Drugs & Therapeutics for Pleurisy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pleurisy

Search NIH Clinical Center for Pleurisy

Genetic Tests for Pleurisy

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Anatomical Context for Pleurisy

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33MalaCards
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MalaCards organs/tissues related to Pleurisy:

33
Lung, T cells, Testes, Nk cells, Breast, Monocytes, Skin

Animal Models for Pleurisy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pleurisy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0IL2RA, IL18, IFNG, MEFV, ADA
2MP:00107688.0IL2RA, IL18, IFNG, MEFV, ADA
3MP:00053877.9ADA, MEFV, IFNG, IL18, IL2RA
4MP:00053787.7ADA, MEFV, IFNG, IL18, IL2RA

Publications for Pleurisy

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52PubMed
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Articles related to Pleurisy:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Mycobacterium intracellulare Pleurisy Identified on Liquid Cultures of the Pleural Fluid and Pleural Biopsy. (23579554)
2013
2
PD-1/PD-Ls pathways between CD4(+) T cells and pleural mesothelial cells in human tuberculous pleurisy. (24406080)
2013
3
Combined NMR and GC-MS Analyses Revealed Dynamic Metabolic Changes Associated with the Carrageenan-Induced Rat Pleurisy. (24131325)
2013
4
Lung squamous cell carcinoma combined with tuberculous pleurisy. (23075740)
2012
5
Factors associated with pleurisy in pigs: a case-control analysis of slaughter pig data for England and Wales. (22363407)
2012
6
Carcinomatosis lymphangitis and pleurisy after allo-SCT in two patients with secondary leukemia after breast cancer. (21383684)
2012
7
Mantle cell lymphoma involvement of the pleura and tuberculous pleurisy with pulmonary tuberculosis: a case report and literature review. (21968964)
2012
8
Diagnostic accuracy of T-cell interferon-I^ release assays in tuberculous pleurisy: a meta-analysis. (21299686)
2011
9
Serum trace element levels in tuberculous pleurisy. (20461473)
2011
10
Non-tuberculous mycobacterial pleurisy: an 8-year single-centre experience in Taiwan. (20392359)
2010
11
Evidence of anti-inflammatory effects of pioglitazone in the murine pleurisy model induced by carrageenan. (19716439)
2009
12
Tuberculous pleurisy after tumour necrosis factor-alpha antagonist usage: case report]. (19123083)
2008
13
Corticosteroids for tuberculous pleurisy. (17943759)
2007
14
Antiinflammatory effects of Tacrolimus in a mouse model of pleurisy. (16860713)
2006
15
Diagnostic value of thoracoscopic pleural biopsy for pleurisy under local anaesthesia. (16916393)
2006
16
Pneumocystis carinii pneumonia with pleurisy, platypnoea and orthodeoxia. (12554907)
2003
17
Positive response to oral chemoendocrine combination therapy using 5"-deoxy-5-fluorouridine for locally advanced breast cancer with carcinomatous pleurisy: report of a case. (14669082)
2003
18
Diagnostic tools in tuberculous pleurisy: a direct comparative study. (14582908)
2003
19
Evaluation of suspected tuberculous pleurisy: clinical and diagnostic findings in HIV-1-positive and HIV-negative adults in Uganda. (11495266)
2001
20
Elevated soluble CD26 levels in patients with tuberculous pleurisy. (11573900)
2001
21
Hypoxemia modifies circulating and exudate neutrophil number and functional responses in carrageenin-induced pleurisy in the rat. (10857850)
2000
22
Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice. (10403502)
1999
23
Regulation of prostaglandin production in carrageenan-induced pleurisy by melatonin. (10451019)
1999
24
Relationship between nitric oxide and prostaglandins in carrageenin pleurisy. (9605435)
1998
25
Tuberculous pleurisy is more common in AIDS than in non-AIDS patients with tuberculosis. (9266874)
1997
26
Adenosine deaminase (ADA) isoenzyme analysis in pleural effusions: diagnostic role, and relevance to the origin of increased ADA in tuberculous pleurisy. (8726940)
1996
27
Use of adenosine deaminase as a diagnostic tool for tuberculous pleurisy. (7638812)
1995
28
Anti-inflammatory effect of magnolol, isolated from Magnolia officinalis, on A23187-induced pleurisy in mice. (8583356)
1995
29
Involvement of leukotriene B4 in zymosan-induced rat pleurisy: inhibition of leukocyte infiltration by the 5-lipoxygenase inhibitor T-0757. (8845830)
1995
30
Tuberculous pleurisy after percutaneous needle biopsy of a pulmonary nodule. (7938803)
1994
31
Antiinflammatory action of thielocin A1 beta, a group II phospholipase A2 specific inhibitor, in rat carrageenan-induced pleurisy. (8491510)
1993
32
Effect of treatment with interleukin-1 receptor antagonist on the development of carrageenan-induced pleurisy in the rat. (8491511)
1993
33
Adenosine deaminase activity and isozyme test for differentiation diagnosis of tuberculous pleurisy]. (7923429)
1993
34
Suppression by cetirizine of pleurisy triggered by antigen in actively sensitized rats. (1362160)
1992
35
Adenosine deaminase in rheumatoid pleurisy. (2035103)
1991
36
Anti-inflammatory effects of cyclosporin A (CsA) in carragheenan-induced pleurisy in rats. (2158217)
1990
37
The usefulness and limitations of adenosine deaminase in the diagnosis of tubercular pleurisy. A meta-analytical study]. (2149157)
1990
38
Change of glycosaminoglycan in pus of patients with purulent pleurisy. (2719860)
1989
39
Prevalence of pleurisy in pigs at slaughter. (3218056)
1988
40
Induction of lymphokine-activated killer cells by intrapleural instillations of recombinant interleukin-2 in patients with malignant pleurisy due to lung cancer. (3493843)
1987
41
The anti-inflammatory mechanism of MK-447 in rat carrageenin-induced pleurisy. (6635213)
1983
42
Low in vitro response to PPD and PHA in lymphocytes from BCG-induced pleurisy in guinea pigs. (7140874)
1982
43
The reduction of tuberculin-induced pleurisy in the guinea-pig by a gold salt, chloroquine and D-penicillamine. (6115933)
1981
44
Influence of some irritating or immunostimulating substances on experimental pleurisy in the rat. (7406599)
1980
45
Action of various drugs with anti-inflammatory or anti-rheumatic properties on pleurisy due to Bordetella pertussis hypersensitivity in the rat. (232922)
1979
46
Sequelae of pleurisy]. (209523)
1978
47
Immunology of lymphocytes in pleurisy and in effusions due to pleural infiltration by chronic lymphocytic leukemia cells. (310227)
1978
48
An outbreak of pleural mesothelioma and chronic fibrosing pleurisy in the village of Karain/UrgA1p in Anatolia. (663877)
1978
49
Radiological case of the month: Tuberculous pleurisy with spinal dissemination. (875474)
1977
50
Meigs' syndrome and pathogenesis of pleurisy and polyserositis. (13760748)
1960

Variations for Pleurisy

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Expression for genes affiliated with Pleurisy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pleurisy

Search GEO for disease gene expression data for Pleurisy.

Pathways for genes affiliated with Pleurisy

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 54R&D Systems, 53QIAGEN
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Pathways related to Pleurisy according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5IL2RA, IL18
2
Show member pathways
9.4MEFV, IL18
3
Show member pathways
IL-2 Signaling pathway38
9.4IL2RA, IFNG
4
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.4IL2RA, IFNG
5
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.4IFNG, IL2RA
69.4IL2RA, IFNG
79.4IL2RA, IFNG
8
Show member pathways
9.4IFNG, IL2RA
99.3IL18, IFNG
109.3IL18, IFNG
119.3IL18, IFNG
12
Show member pathways
9.3IL18, IFNG
139.3IFNG, IL18
14
Show member pathways
IL27-mediated signaling events38
9.3IFNG, IL18
159.3IFNG, IL18
169.3IFNG, IL18
178.9IL2RA, IL18, IFNG
18
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.9IL2RA, IL18, IFNG
19
Show member pathways
8.9IL2RA, IL18, IFNG
20
Show member pathways
8.9IL2RA, IL18, IFNG
21
Show member pathways
8.9IL2RA, IL18, IFNG
22
Show member pathways
8.9IFNG, IL18, IL2RA
23
Show member pathways
8.9IFNG, IL18, IL2RA
24
Show member pathways
8.7PLA2G7, IL2RA, IL18

Compounds for genes affiliated with Pleurisy

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45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB
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Compounds related to Pleurisy according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1pentostatin45 61 29 1113.0IL2RA, ADA
2sodium stibogluconate45 1110.8ADA, IFNG
3gluten459.8IL18, IL2RA
4amphotericin b459.7ADA, IFNG
5levamisole45 1110.7IL2RA, IL18
6gold sodium thiomalate459.7IFNG, IL2RA
7pirfenidone45 6110.7IFNG, IL2RA
8ranitidine45 29 24 1112.6ADA, IL18, IL2RA
9il-12459.5IL18, IFNG
102,5-oligoadenylate459.5ADA, IFNG, IL2RA
11indoleamine459.4IFNG, IL18
12methotrexate51 45 1111.4IL18, IL2RA, ADA
13ribavirin45 51 1111.4IL18, ADA, IFNG
14imiquimod45 61 29 1112.3IFNG, IL18
15natalizumab45 1110.3IFNG, IL18, IL2RA
16con a459.3IFNG, IL18, IL2RA
17epinephrine45 24 1111.3IL2RA, IL18, ADA
18il 10459.3IL2RA, IFNG, IL18
19mycophenolate mofetil45 51 1111.3IFNG, IL18, IL2RA
20infliximab45 51 1111.3IFNG, IL18, IL2RA
21pentoxifylline45 1110.3IL18, IFNG, IL2RA
22ifn-alpha459.3IL2RA, IL18, IFNG
23thalidomide45 51 61 1112.3IL2RA, IL18, IFNG
24prednisolone45 29 1111.2IL2RA, IL18, IFNG
25ionomycin459.2IFNG, IL18, IL2RA
26tacrolimus45 51 1111.2IL2RA, IL18, IFNG
27acetylcholine45 51 29 24 1113.1IL18, ADA, IL2RA
28doxorubicin45 51 1111.1IL2RA, PSG2, IL18, ADA
29creatinine459.1ADA, PSG2, IL18, IL2RA
30p002459.1PLA2G7, IL18, PSG2
31rantes459.1IFNG, IL2RA, IL18
32atorvastatin45 51 29 24 1113.0PLA2G7, IL2RA, IL18
33ivig459.0PLA2G7, IFNG, IL2RA
34tuberculin459.0IL2RA, IFNG, IL18, ADA
35neopterin459.0IL2RA, IL18, IFNG, ADA
36indomethacin45 29 61 1111.9IL2RA, ADA, IL18, IFNG
37histamine45 29 2410.9ADA, IFNG, IL18, IL2RA
385fluorouracil458.9IL2RA, PSG2, IL18, IFNG
39cyclosporin a45 29 6110.9IFNG, IL18, IL2RA, ADA
40thymidine45 249.8IL18, IL2RA, IFNG, PSG2
41norepinephrine45 24 1110.8ADA, IL2RA, IL18
42arginine458.8ADA, IFNG, IL18, IL2RA
43aspirin45 51 29 2411.7ADA, IL18, PLA2G7, IL2RA
44vegf458.5PSG2, IL2RA, IL18, IFNG, ADA
45pge2458.4IFNG, IL2RA, PLA2G7, IL18
46endotoxin458.4IFNG, MEFV, IL18, PLA2G7
47cysteine458.4IL2RA, IL18, IFNG, ADA
48nitric oxide45 24 1110.4PSG2, PLA2G7, IFNG, IL18
49estrogen458.4PLA2G7, IL18, IL2RA, ADA
50dexamethasone45 51 29 1111.1IL2RA, IL18, PLA2G7, ADA, IFNG

GO Terms for genes affiliated with Pleurisy

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16Gene Ontology
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Cellular components related to Pleurisy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7IL2RA, IFNG, ADA
2extracellular regionGO:0055768.1PLA2G7, IL18, IFNG, PSG2

Biological processes related to Pleurisy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of activated T cell proliferationGO:0421049.2IL2RA, IL18
2positive regulation of inflammatory responseGO:0507299.1PLA2G7, IL18
3negative regulation of inflammatory responseGO:0507289.0IL2RA, MEFV, ADA

Products for genes affiliated with Pleurisy

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Sources for Pleurisy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet