Aliases & Classifications for Pleurisy

Summaries for Pleurisy

Disease Ontology : 12 A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs.

MalaCards based summary : Pleurisy is related to pleural tuberculosis and pleural disease, and has symptoms including dyspnea and pleuritic pain. An important gene associated with Pleurisy is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and neutrophil, and related phenotypes are cardiovascular system and cellular

Wikipedia : 72 Pleurisy, also known as pleuritis, is inflammation of the membranes (pleurae) that surround the lungs... more...

Related Diseases for Pleurisy

Diseases related to Pleurisy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 pleural tuberculosis 32.1 ADA CCL2 CXCL8 IFNG TNF
2 pleural disease 32.1 ADA CRP MPO TNF
3 extrapulmonary tuberculosis 31.9 ADA CCL2 IFNG
4 pleural empyema 31.4 ADA CRP
5 tuberculous peritonitis 31.4 ADA CRP IFNG TNF
6 familial mediterranean fever 31.0 CRP MEFV TNF
7 mycobacterium tuberculosis 1 30.4 ADA IFNG SELL TNF
8 tuberculous empyema 30.0 ADA IL2
9 arthritis 29.9 CCL2 CXCL8 IFNG TNF
10 pulmonary tuberculosis 29.9 ADA IFNG IL2 TNF
11 pneumonia 29.7 CCL2 CRP CXCL8 MPO TNF
12 interstitial lung disease 29.5 CCL2 CXCL8 IFNG TNF
13 lymphadenitis 29.5 CXCL8 ICAM1 IFNG TNF
14 lung disease 29.5 CCL2 CXCL8 MPO TNF
15 synovitis 29.3 CRP CXCL8 ICAM1 TNF
16 colitis 29.2 CXCL8 IFNG IL2 MPO TNF
17 adult-onset still's disease 29.1 CRP MEFV TNF
18 pulmonary sarcoidosis 29.0 CCL2 ICAM1 IFNG IL2 TNF
19 keratoconjunctivitis 29.0 CXCL8 ICAM1 IFNG IL2 TNF
20 arthus reaction 29.0 ALOX5 ICAM1 SELL TNF
21 pericarditis 28.9 ADA CRP MEFV TNF
22 ulcerative colitis 28.8 CRP CXCL8 IFNG IL2 MPO TNF
23 systemic lupus erythematosus 28.7 CCL2 CRP ICAM1 IFNG IL2 MPO
24 rheumatoid arthritis 28.7 CCL2 CRP CXCL8 ICAM1 IFNG IL2
25 peritonitis 27.8 ADA CCL2 CRP CXCL8 ICAM1 IFNG
26 pleuropneumonia 11.2
27 epidemic pleurodynia 10.9
28 inflammatory diarrhea 10.5 CXCL8 MPO
29 israeli tick typhus 10.4 CCL2 CXCL8
30 autoimmune inner ear disease 10.4 MPO TNF
31 staphylococcal toxic shock syndrome 10.4 IFNG TNF
32 mononeuritis multiplex 10.4 CRP MPO
33 aortitis 10.4 CRP MPO
34 variola major 10.4 IFNG IL2
35 denture stomatitis 10.4 CCL2 CXCL8
36 chronic beryllium disease 10.4 IFNG TNF
37 microscopic polyangiitis 10.4 MPO TNF
38 slow-channel congenital myasthenic syndrome 10.4 CRP CXCL8
39 trichosporonosis 10.4 IFNG TNF
40 berylliosis 10.4 IFNG IL2
41 tungiasis 10.4 CXCL8 TNF
42 pyuria 10.3 CRP CXCL8
43 anthracosis 10.3 CCL2 TNF
44 oral tuberculosis 10.3 IL2 TNF
45 mediastinitis 10.3 CRP MPO
46 acute proliferative glomerulonephritis 10.3 CCL2 ICAM1 MPO
47 herpes simplex virus keratitis 10.3 CCL2 CXCL8 ICAM1
48 immune suppression 10.3 IFNG IL2
49 extrinsic allergic alveolitis 10.3 CCL2 CXCL8 MPO
50 crescentic glomerulonephritis 10.3 CCL2 ICAM1 MPO

Graphical network of the top 20 diseases related to Pleurisy:



Diseases related to Pleurisy

Symptoms & Phenotypes for Pleurisy

UMLS symptoms related to Pleurisy:


dyspnea, pleuritic pain

MGI Mouse Phenotypes related to Pleurisy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 TNF ADA IL2 ALOX5 CRP MPO
2 cellular MP:0005384 10.02 TNF IFNG ADA IL2 ALOX5 MEFV
3 hematopoietic system MP:0005397 9.97 TNF ADA IL2 ALOX5 MEFV MPO
4 homeostasis/metabolism MP:0005376 9.96 TNF IFNG ADA IL2 ALOX5 MEFV
5 immune system MP:0005387 9.9 ADA IL2 ALOX5 MEFV CCL2 CRP
6 liver/biliary system MP:0005370 9.43 TNF IFNG ADA IL2 MEFV SELL
7 respiratory system MP:0005388 9.1 TNF IFNG ADA IL2 ENO2 SELL

Drugs & Therapeutics for Pleurisy

Drugs for Pleurisy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 53477736 447043 55185
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3 564-25-0 54671203
3
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
5
Cefazolin Approved Phase 4 25953-19-9 33255 656510
6
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
7
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
9
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
10
Ofloxacin Approved Phase 4 82419-36-1 4583
11 Anti-Bacterial Agents Phase 4,Phase 3
12 Antibiotics, Antitubercular Phase 4,Phase 3
13 Anti-Infective Agents Phase 4,Phase 3
14 Antitubercular Agents Phase 4,Phase 3
15 Antimalarials Phase 4,Phase 3
16 Antiparasitic Agents Phase 4,Phase 3
17 Antiprotozoal Agents Phase 4,Phase 3
18 Anti-Inflammatory Agents Phase 4,Phase 2
19 Peripheral Nervous System Agents Phase 4
20 Clindamycin palmitate Phase 4
21 Clindamycin phosphate Phase 4
22 Antineoplastic Agents, Hormonal Phase 4,Phase 2
23 glucocorticoids Phase 4,Phase 2
24 Hormone Antagonists Phase 4,Phase 2
25 Hormones Phase 4,Phase 2
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
27 Methylprednisolone acetate Phase 4
28 Methylprednisolone Hemisuccinate Phase 4
29 Prednisolone acetate Phase 4
30 Prednisolone hemisuccinate Phase 4
31 Prednisolone phosphate Phase 4
32 Protective Agents Phase 4
33 Topoisomerase Inhibitors Phase 4
34 Antiemetics Phase 4
35 Autonomic Agents Phase 4
36 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
37 Cytochrome P-450 Enzyme Inhibitors Phase 4
38 Gastrointestinal Agents Phase 4
39 Neuroprotective Agents Phase 4
40 Renal Agents Phase 4
41
Colchicine Approved Phase 3 64-86-8 2833 6167
42 Antirheumatic Agents Phase 3,Phase 2
43 Antimitotic Agents Phase 3
44 Interleukin 1 Receptor Antagonist Protein Phase 3
45
Abatacept Approved Phase 2 332348-12-6 10237
46
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
47 Immunosuppressive Agents Phase 2
48
Bevacizumab Approved, Investigational Phase 1 216974-75-3
49 Angiogenesis Inhibitors Phase 1
50 Angiogenesis Modulating Agents Phase 1

Interventional clinical trials:

(show all 36)

# Name Status NCT ID Phase Drugs
1 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Unknown status NCT00313066 Phase 4
2 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
3 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
4 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
5 Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy Completed NCT02446782 Phase 4 Cefazolin
6 Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia Recruiting NCT02618057 Phase 4 Prednisolone;Levofloxacin
7 Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever Completed NCT01705756 Phase 3 Kineret
8 Antibiotic Treatment of Gulf War Veterans' Illnesses Completed NCT00007735 Phase 3 Doxycycline (200mg/day) or Placebo
9 Abatacept in the Treatment and Prevention of Active Systemic Lupus Erythematosus (SLE) Flares in Combination With Prednisone Completed NCT00119678 Phase 2 Abatacept;Placebo;Prednisone;Abatacept
10 Intrapleural Bevacizumab After Pleural Drainage in the Context of Breast Cancer Terminated NCT02250118 Phase 1 Bevacizumab
11 Evaluating the Diagnostic Validity of Inflammation-associated Markers for Tuberculous Pleurisy Unknown status NCT01685099
12 Magnetic Resonance (MR) Spectroscopy In Familial Mediterranean Fever (FMF) Patients Unknown status NCT00658060
13 NSAIDs Treatment in Children With Pleuropneumonia Unknown status NCT01586299 Ibuprofen;Acetaminophen
14 Evaluation of a Serology Diagnostic Kit for the Detection of Genital Mycoplasma in Pregnancy Unknown status NCT01281319
15 Prevalence and Clinical Significance of Co-infection of Mycoplasma Pneumoniae in Patients With Pulmonary Tuberculosis Unknown status NCT00926601
16 Corticosteroids in the Treatment of Tuberculous Pleurisy Completed NCT00338793 prednisolone
17 Procalcitonin in Pleural Pleuritis Completed NCT01011881
18 Drainage of Tuberculous Pleural Effusions Completed NCT00524147
19 Outcome of Patients Undiagnosed Under Medical Thoracoscopy Completed NCT01356979
20 A Trial of Rigid Versus Semirigid Thoracoscopy in the Evaluation of Exudative Pleural Effusions Completed NCT01726556
21 Serum Biomarkers in Diagnosis of Mesothelioma Completed NCT02029105
22 Predictive Factors and Outcome in Medical Thoracoscopy Completed NCT02288065 sterile talc pleurodesis
23 Lung Ultrasound in Pleuritic Chest Pain Completed NCT02107001
24 Extravascular Lung Water Monitoring by Combined Ultrasound and Bioimpedance as a Guide for Treatment in Hemodialysis Patients Completed NCT01815762
25 Efficiency and Safety of Pleural Biopsy Methods in the Diagnosis of Pleural Diseases Completed NCT03153501
26 Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy Completed NCT00720954
27 Detection of Mycoplasma Pneumoniae Completed NCT02511262
28 The Optimization of Mycoplasm Pneumonia Antibiotic Therapy Completed NCT01259141 Moxifloxacin;Cephalosporins and azithromycin
29 Randomized Controlled Trial of Doxycycline to Prevent Acquisition of Mycoplasma Pneumoniae in an Outbreak Setting Completed NCT00207584 Doxycycline treatment
30 Chlamydia and Mycoplasma in Coronary Artery Disease Completed NCT00561028
31 Yield of Cryoprobe vs Flexible Forceps Pleural Biopsy Recruiting NCT02500277
32 Thoracic Ultrasound in the Treatment of Pleural Effusion Recruiting NCT02505763
33 Pathophysiological Effects of Intrapleural Pressure Changes During Therapeutic Thoracentesis Recruiting NCT02192138
34 Methylprednisolone for Children With Severe Mycoplasma Pneumoniae Pneumonia (MCMP) Recruiting NCT02303587 methylprednisolone
35 Natural History of Nonspecific Pleuritis Diagnosed After Video-assisted-thoracoscopic-surgery Not yet recruiting NCT03270228
36 Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children Terminated NCT01217099 methylprednisolone;azithromycin

Search NIH Clinical Center for Pleurisy

Genetic Tests for Pleurisy

Anatomical Context for Pleurisy

MalaCards organs/tissues related to Pleurisy:

38
Lung, T Cells, Neutrophil, Breast, Testes, Nk Cells, Bone

Publications for Pleurisy

Articles related to Pleurisy:

(show top 50) (show all 600)
# Title Authors Year
1
Success rate of medical thoracoscopy and talc pleurodesis in malignant pleurisy: A single-centre experience. ( 29320805 )
2018
2
Clinical Features of Nontuberculous Mycobacterial Pleurisy: A Review of 12 Cases. ( 29033435 )
2018
3
Successful treatment of non-tuberculous mycobacterial pleurisy with acute fever by antimycobacterial therapy. ( 29437801 )
2018
4
Bilateral Tuberculous Pleurisy with Subsequent Upper Lobe Predominant Pulmonary Fibrosis Mimicking Pleuroparenchymal Fibroelastosis. ( 29033441 )
2018
5
Diagnostic value of T-Spot TB combined with INF-I^ and IL-27 in tuberculous pleurisy. ( 29399137 )
2018
6
Inhibition of inflammasome activation improves lung acute injury induced by carrageenan in a mouse model of pleurisy. ( 28461340 )
2017
7
Diagnosis of tuberculous pleurisy with combination of adenosine deaminase and interferon-I^ immunospot assay in a tuberculosis-endemic population: A prospective cohort study. ( 29381918 )
2017
8
Mycobacterium tuberculosis Rv3615c is a highly immunodominant antigen and specifically induces potent Th1-type immune responses in tuberculosis pleurisy. ( 28588103 )
2017
9
Peripheral blood mononuclear cells from rat model of pleurisy: The effects of hesperidin on ectoenzymes activity, apoptosis, cell cycle and reactive oxygen species production. ( 28460230 )
2017
10
Pleurisy Caused by Mycobacterium abscessus in a Young Patient with Dermatomyositis: A Case Report and Brief Review of the Literature. ( 29269658 )
2017
11
Ulcerative colitis with acute pleurisy: A case report and review of the literature. ( 28746225 )
2017
12
Erratum: Evaluation of different laboratory methods for rapid diagnosis of tuberculous pleurisy. ( 28317818 )
2017
13
Corticosteroids for tuberculous pleurisy. ( 28290161 )
2017
14
Calea uniflora Less. attenuates the inflammatory response to carrageenan-induced pleurisy in mice. ( 27912150 )
2017
15
Transmembrane Tumor Necrosis Factor Controls Myeloid-Derived Suppressor Cell Activity via TNF Receptor 2 and Protects from Excessive Inflammation during BCG-Induced Pleurisy. ( 28890718 )
2017
16
Pirfenidone-induced Eosinophilic Pleurisy. ( 28717083 )
2017
17
The efficacy and safety of adjunctive corticosteroids in the treatment of tuberculous pleurisy: a systematic review and meta-analysis. ( 29137345 )
2017
18
Accuracy of interleukin-27 assay for the diagnosis of tuberculous pleurisy: A PRISMA-compliant meta-analysis. ( 29390341 )
2017
19
Comparison of laboratory testing methods for the diagnosis of tuberculous pleurisy in China. ( 28674427 )
2017
20
Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy. ( 28657497 )
2017
21
Long-term outcome of patients with nonspecific pleurisy at medical thoracoscopy. ( 28284315 )
2017
22
CT findings of pulmonary tuberculosis and tuberculous pleurisy in diabetes mellitus patients. ( 28185999 )
2017
23
The Ethanolic Stem-Bark Extract of Antrocaryon micraster Inhibits Carrageenan-Induced Pleurisy and Pedal Oedema in Murine Models of Inflammation. ( 28798953 )
2017
24
The roles of a ribosomal protein S19 polymer in a mouse model of carrageenan-induced acute pleurisy. ( 28190533 )
2017
25
Diagnostic value of interferon-I^-induced protein of 10kDa for tuberculous pleurisy: A meta-analysis. ( 28577960 )
2017
26
Associates and predictors of pleurisy or pericarditis in SLE. ( 29118999 )
2017
27
Antiinflammatory properties of betulinic acid and xylopic acid in the carrageenan-induced pleurisy model of lung inflammation in mice. ( 29243291 )
2017
28
Long-lasting tuberculous pleurisy. ( 28546275 )
2017
29
Long-lasting tuberculous pleurisy. ( 28546270 )
2017
30
Progression of Tuberculous Pleurisy: From a Lymphocyte-Predominant Free-Flowing Effusion to a Neutrophil-Predominant Loculated Effusion. ( 28119752 )
2017
31
Role of MCP-1 in pleural effusion development in a carrageenan-induced murine model of pleurisy. ( 27878909 )
2016
32
Evaluation of different laboratory methods for rapid diagnosis of tuberculous pleurisy. ( 27931685 )
2016
33
Evaluation of a whole-blood chemiluminescent immunoassay of IFN-I^, IP-10, and MCP-1 for diagnosis of active pulmonary tuberculosis and tuberculous pleurisy patients. ( 27523388 )
2016
34
Anti-inflammatory effect of volatile oil from Schizonepeta tenuifolia on carrageenin-induced pleurisy in rats and its application to study of appropriate harvesting time coupled with multi-attribute comprehensive index method. ( 27765609 )
2016
35
Diagnostic accuracy of tumor necrosis factor-alpha assay for tuberculous pleurisy: A PRISMA-compliant meta-analysis. ( 27902616 )
2016
36
A diagnostic algorithm for tuberculous pleurisy using the ELISPOT assay on peripheral blood and pleural effusion. ( 27187759 )
2016
37
Analysis of Cytokine Levers in Pleural Effusions of Tuberculous Pleurisy and Tuberculous Empyema. ( 27034588 )
2016
38
The anti-inflammatory effect of Ilex paraguariensis A. St. Hil (Mate) in a murine model of pleurisy. ( 27155392 )
2016
39
Tissue-infiltrating mucosal-associated invariant T cells play an important role against Mycobacterium tuberculosis infection in tuberculosis pleurisy. ( 27507648 )
2016
40
Inhibition of the NF-I_B and p38 MAPK pathways by scopoletin reduce the inflammation caused by carrageenan in the mouse model of pleurisy. ( 27324858 )
2016
41
Dynamic Analysis of Changes of Protein Levels and Selected Biochemical Indices in Rat Serum in the Course of Experimental Pleurisy. ( 27083876 )
2016
42
TB/HIV pleurisy reduces Th17 lymphocyte proportion independent of the cytokine microenvironment. ( 27450010 )
2016
43
Diagnostic Performance of Different Pleural Fluid Biomarkers in Tuberculous Pleurisy. ( 25523627 )
2015
44
Tuberculous pleurisy drives marked effector responses of I^I', CD4+, and CD8+ T cell subpopulations in humans. ( 26156008 )
2015
45
Co-existent Ascariasis and Multiloculated Tuberculous Pleurisy Treated with Intrapleural Streptokinase. ( 26522189 )
2015
46
Recruitment of IL-27-Producing CD4(+) T Cells and Effect of IL-27 on Pleural Mesothelial Cells in Tuberculous Pleurisy. ( 25944255 )
2015
47
Impact of Implementation of an Automated Liquid Culture System on Diagnosis of Tuberculous Pleurisy. ( 26130948 )
2015
48
7-prenyloxi-6-methoxycoumarin from Polygala sabulosa A.W. Bennett Regulates p38 MAPK and NF-kB Pathways Inhibiting the Inflammation Induced by Carrageenan in the Mouse Model of Pleurisy. ( 26434700 )
2015
49
Treatment of free-flowing tuberculous pleurisy with intrapleural urokinase. ( 26467594 )
2015
50
Diagnostic accuracy of pleural fluid tumor necrosis factor-I+ in tuberculous pleurisy: A meta-analysis. ( 26622262 )
2015

Variations for Pleurisy

Expression for Pleurisy

Search GEO for disease gene expression data for Pleurisy.

Pathways for Pleurisy

Pathways related to Pleurisy according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 ALOX5 CCL2 CRP CXCL8 ICAM1 IFNG
2
Show member pathways
13.28 ALOX5 CCL2 CXCL8 ICAM1 IFNG IL2
3
Show member pathways
12.8 CXCL8 ICAM1 IFNG IL2 TNF
4
Show member pathways
12.71 CCL2 CXCL8 ICAM1 IFNG IL2 TNF
5
Show member pathways
12.54 CCL2 IFNG IL2 MPO TNF
6
Show member pathways
12.47 CCL2 CXCL8 IFNG IL2 TNF
7
Show member pathways
12.46 ICAM1 IFNG IL2 TNF
8 12.45 ALOX5 CCL2 IFNG IL2 MPO TNF
9
Show member pathways
12.29 CCL2 CXCL8 IFNG TNF
10
Show member pathways
12.11 CXCL8 IFNG IL2 TNF
11 12.06 CCL2 ICAM1 IFNG TNF
12 11.9 CCL2 ICAM1 TNF
13 11.9 IFNG IL2 MPO SELL TNF
14
Show member pathways
11.88 IFNG IL2 TNF
15 11.86 CCL2 CXCL8 ICAM1 TNF
16 11.86 ALOX5 CCL2 CXCL8 ICAM1 TNF
17 11.84 CXCL8 IFNG TNF
18 11.83 CXCL8 ICAM1 TNF
19 11.75 IFNG IL2 TNF
20 11.74 CXCL8 ICAM1 IFNG IL2
21 11.72 CCL2 CXCL8 ICAM1 IFNG TNF
22
Show member pathways
11.69 CXCL8 IFNG IL2 TNF
23 11.66 IFNG IL2 SELL TNF
24 11.64 CCL2 CXCL8 TNF
25
Show member pathways
11.62 IFNG IL2 TNF
26
Show member pathways
11.56 ALOX5 CCL2 CRP ICAM1 IFNG IL2
27 11.54 IFNG IL2 TNF
28
Show member pathways
11.52 CXCL8 ICAM1 IFNG IL2 TNF
29 11.51 CCL2 CXCL8 ICAM1 IFNG IL2 TNF
30 11.5 ICAM1 MPO TNF
31 11.5 IFNG IL2 TNF
32 11.49 CCL2 IFNG TNF
33 11.47 CCL2 CXCL8 ICAM1 TNF
34 11.45 CXCL8 ICAM1 IFNG
35
Show member pathways
11.36 IFNG IL2 TNF
36 11.34 ICAM1 IFNG TNF
37 11.24 IFNG IL2 TNF
38 11.24 CCL2 CXCL8 ICAM1 IFNG TNF
39 11.18 CCL2 CXCL8 IL2 TNF
40 11.15 CCL2 ICAM1 IFNG
41 11.01 CRP CXCL8 TNF
42 10.76 CCL2 ICAM1 MPO TNF

GO Terms for Pleurisy

Cellular components related to Pleurisy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 ALOX5 CCL2 CRP CXCL8 IFNG IL2
2 external side of plasma membrane GO:0009897 9.56 ADA ICAM1 SELL TNF
3 intracellular GO:0005622 9.5 CCL2 CXCL8 ENO2 IFNG IL2 MEFV
4 extracellular space GO:0005615 9.36 ADA ALOX5 CCL2 CRP CXCL8 ENO2

Biological processes related to Pleurisy according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.92 ADA CCL2 ICAM1 IL2 SELL
2 immune response GO:0006955 9.83 CCL2 CXCL8 IFNG IL2 TNF
3 regulation of receptor activity GO:0010469 9.8 CCL2 CXCL8 IFNG IL2 TNF
4 defense response GO:0006952 9.78 CXCL8 MPO TNF
5 cellular response to tumor necrosis factor GO:0071356 9.77 CCL2 CXCL8 ICAM1
6 negative regulation of inflammatory response GO:0050728 9.71 ADA IL2 MEFV
7 cellular response to interleukin-1 GO:0071347 9.67 CCL2 CXCL8 ICAM1
8 humoral immune response GO:0006959 9.63 CCL2 IFNG TNF
9 positive regulation of osteoclast differentiation GO:0045672 9.61 IFNG TNF
10 positive regulation of T cell differentiation GO:0045582 9.6 ADA IL2
11 leukocyte tethering or rolling GO:0050901 9.58 SELL TNF
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IFNG TNF
13 negative regulation of growth of symbiont in host GO:0044130 9.57 MPO TNF
14 regulation of regulatory T cell differentiation GO:0045589 9.56 IFNG IL2
15 PERK-mediated unfolded protein response GO:0036499 9.55 CCL2 CXCL8
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 ICAM1 IFNG TNF
17 negative regulation of lipid storage GO:0010888 9.51 CRP TNF
18 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.48 ICAM1 TNF
19 cellular response to lipopolysaccharide GO:0071222 9.46 CCL2 CXCL8 ICAM1 TNF
20 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IFNG TNF
21 positive regulation of vitamin D biosynthetic process GO:0060557 9.26 IFNG TNF
22 embryonic digestive tract development GO:0048566 9.13 ADA CXCL8 TNF
23 inflammatory response GO:0006954 9.1 ALOX5 CCL2 CRP CXCL8 MEFV TNF

Molecular functions related to Pleurisy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL2 CXCL8 IFNG IL2 TNF
2 glycosphingolipid binding GO:0043208 8.96 IL2 SELL

Sources for Pleurisy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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