Aliases & Classifications for Pleurisy

Summaries for Pleurisy

Disease Ontology : 12 A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs.

MalaCards based summary : Pleurisy is related to tuberculosis and pulmonary tuberculosis, and has symptoms including pleuritic pain and dyspnea. An important gene associated with Pleurisy is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Tetracycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and neutrophil, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and cardiovascular system

Wikipedia : 71 Pleurisy, also known as pleuritis, is inflammation of the membranes (pleurae) that surround the lungs... more...

Related Diseases for Pleurisy

Diseases related to Pleurisy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 271)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 30.6 CCL2 IL2 TNF
2 pulmonary tuberculosis 29.9 CXCL8 IFNG TNF
3 tularemia 29.5 IFNG IL2 TNF
4 chronic lymphocytic leukemia 29.5 IFNG MPO TNF
5 hepatitis 29.5 IFNG IL2 TNF
6 rheumatoid arthritis 28.8 CCL2 CRP CXCL8 ICAM1 IFNG IL2
7 pleural tuberculosis 11.4
8 pleural disease 11.3
9 pleuropneumonia 11.1
10 familial mediterranean fever, ar 10.8
11 epidemic pleurodynia 10.8
12 pleural empyema 10.8
13 autosomal dominant charcot-marie-tooth disease type 2 with giant axons 10.3 MPO TNF
14 oral cavity carcinoma in situ 10.2 ADA CCL2 IFNG
15 immune-complex glomerulonephritis 10.2 CCL2 IFNG MPO
16 stocco dos santos syndrome 10.2 IFNG TNF
17 cutaneous candidiasis 10.2 CCL2 CXCL8 ICAM1
18 steatitis 10.2 IL2 TNF
19 urethral intrinsic sphincter deficiency 10.2 CCL2 IFNG TNF
20 hyperlucent lung 10.2 CCL2 CRP IFNG
21 paralytic poliomyelitis 10.2 IFNG IL2
22 breast apocrine carcinoma in situ 10.2 CCL2 CXCL8 MPO
23 hydrophthalmos 10.2 CXCL8 ICAM1 IFNG
24 caplan's syndrome 10.2 IFNG IL2
25 stiff-person syndrome 10.2 CCL2 CRP IFNG
26 mirizzi syndrome 10.2 MPO TNF
27 esophagus lymphoma 10.2 CXCL8 IFNG TNF
28 senile reticular retinal degeneration 10.2 CXCL8 IFNG TNF
29 sosby syndrome 10.2 CRP CXCL8
30 allergic bronchopulmonary aspergillosis 10.2 CCL2 CRP CXCL8
31 epidermolysis bullosa simplex, sutosomal recessive 2 10.2 CCL2 CXCL8 ICAM1
32 hypotrichosis 4 10.2 ICAM1 IFNG TNF
33 status epilepticus 10.2 CCL2 IFNG TNF
34 neurotic disorder 10.2 ICAM1 IFNG TNF
35 conduct disorder 10.2 ICAM1 IFNG TNF
36 oral cavity cancer 10.2 ICAM1 IFNG TNF
37 central nervous system origin vertigo 10.2 IFNG IL2 MPO
38 depressed scar 10.2 CXCL8 IFNG TNF
39 functional gastric disease 10.2 ADA CRP TNF
40 classic type lipoma 10.1 CXCL8 IFNG TNF
41 plummer's disease 10.1 CRP IFNG TNF
42 cockayne syndrome, type b 10.1 ADA IFNG TNF
43 follicular adenoma 10.1 CRP IFNG TNF
44 scalp dermatosis 10.1 CRP MPO TNF
45 rift valley fever 10.1 CRP IFNG TNF
46 intra-abdominal lymph node mast cell malignancy 10.1 CRP CXCL8 ICAM1
47 cicatricial lagophthalmos 10.1 CRP CXCL8 TNF
48 autosomal dominant deafness-onychodystrophy syndrome 10.1 IFNG IL2 TNF
49 fungal gastritis 10.1 CXCL8 IFNG TNF
50 pyoderma gangrenosum 10.1 CXCL8 IFNG TNF

Graphical network of the top 20 diseases related to Pleurisy:



Diseases related to Pleurisy

Symptoms & Phenotypes for Pleurisy

UMLS symptoms related to Pleurisy:


pleuritic pain, dyspnea

GenomeRNAi Phenotypes related to Pleurisy according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 CXCL8 ICAM1 IL2 MPO TGFB1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CXCL8 ICAM1 IL2 MPO TGFB1 TNF

MGI Mouse Phenotypes related to Pleurisy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 ADA ALOX5 CRP ICAM1 IFNG IL2
2 homeostasis/metabolism MP:0005376 10.11 MEFV MPO SELL TGFB1 TNF ADA
3 hematopoietic system MP:0005397 10.1 ADA ALOX5 ICAM1 IFNG IL2 MEFV
4 immune system MP:0005387 10.1 TGFB1 TNF ADA ALOX5 CCL2 CRP
5 endocrine/exocrine gland MP:0005379 9.98 ADA ICAM1 IFNG IL2 SELL TGFB1
6 digestive/alimentary MP:0005381 9.93 ADA ICAM1 IFNG IL2 TGFB1 TNF
7 liver/biliary system MP:0005370 9.8 ADA IFNG IL2 MEFV SELL TGFB1
8 muscle MP:0005369 9.63 TNF ADA ICAM1 IFNG MPO TGFB1
9 neoplasm MP:0002006 9.43 ICAM1 IFNG IL2 SELL TGFB1 TNF
10 respiratory system MP:0005388 9.1 ADA IFNG IL2 SELL TGFB1 TNF

Drugs & Therapeutics for Pleurisy

Drugs for Pleurisy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
2
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
3
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3 564-25-0 54671203
4
Lymecycline Approved Phase 4 992-21-2 5280963
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Cefazolin Approved Phase 4 25953-19-9 656510 33255
7
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
8
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
9
Ofloxacin Approved Phase 4 82419-36-1 4583
10
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
11 Peripheral Nervous System Agents Phase 4
12 Anti-Bacterial Agents Phase 4,Phase 3
13 Anti-Infective Agents Phase 4,Phase 3
14 Anti-Inflammatory Agents Phase 4,Phase 2
15 Antimalarials Phase 4,Phase 3
16 Antibiotics, Antitubercular Phase 4,Phase 3
17 Antitubercular Agents Phase 4,Phase 3
18 Antiparasitic Agents Phase 4,Phase 3
19 Antiprotozoal Agents Phase 4,Phase 3
20 Prednisolone acetate Phase 4
21 glucocorticoids Phase 4,Phase 2
22 Clindamycin palmitate Phase 4
23 Clindamycin phosphate Phase 4
24 Topoisomerase Inhibitors Phase 4
25 Hormone Antagonists Phase 4,Phase 2
26 Hormones Phase 4,Phase 2
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
28 Prednisolone hemisuccinate Phase 4
29 Prednisolone phosphate Phase 4
30 Protective Agents Phase 4
31 Methylprednisolone acetate Phase 4
32 Methylprednisolone Hemisuccinate Phase 4
33 Antineoplastic Agents, Hormonal Phase 4,Phase 2
34 Gastrointestinal Agents Phase 4
35 Neuroprotective Agents Phase 4
36 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
37 Cytochrome P-450 Enzyme Inhibitors Phase 4
38 Antiemetics Phase 4
39 Renal Agents Phase 4
40 Autonomic Agents Phase 4
41
Colchicine Approved Phase 3 64-86-8 6167 2833
42 Antirheumatic Agents Phase 3,Phase 2
43 Interleukin 1 Receptor Antagonist Protein Phase 3
44 Antimitotic Agents Phase 3
45
Abatacept Approved Phase 2 332348-12-6 10237
46
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
47 Immunosuppressive Agents Phase 2
48
Bevacizumab Approved, Investigational Phase 1 216974-75-3
49 Angiogenesis Inhibitors Phase 1
50 Angiogenesis Modulating Agents Phase 1

Interventional clinical trials:

(show all 35)
id Name Status NCT ID Phase
1 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Unknown status NCT00313066 Phase 4
2 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
3 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
4 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4
5 Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy Completed NCT02446782 Phase 4
6 Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia Recruiting NCT02618057 Phase 4
7 Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever Completed NCT01705756 Phase 3
8 Antibiotic Treatment of Gulf War Veterans' Illnesses Completed NCT00007735 Phase 3
9 Abatacept in the Treatment and Prevention of Active Systemic Lupus Erythematosus (SLE) Flares in Combination With Prednisone Completed NCT00119678 Phase 2
10 Intrapleural Bevacizumab After Pleural Drainage in the Context of Breast Cancer Terminated NCT02250118 Phase 1
11 Evaluating the Diagnostic Validity of Inflammation-associated Markers for Tuberculous Pleurisy Unknown status NCT01685099
12 Pathophysiological Effects of Intrapleural Pressure Changes During Therapeutic Thoracentesis Unknown status NCT02192138
13 Magnetic Resonance (MR) Spectroscopy In Familial Mediterranean Fever (FMF) Patients Unknown status NCT00658060
14 NSAIDs Treatment in Children With Pleuropneumonia Unknown status NCT01586299
15 Evaluation of a Serology Diagnostic Kit for the Detection of Genital Mycoplasma in Pregnancy Unknown status NCT01281319
16 Prevalence and Clinical Significance of Co-infection of Mycoplasma Pneumoniae in Patients With Pulmonary Tuberculosis Unknown status NCT00926601
17 Corticosteroids in the Treatment of Tuberculous Pleurisy Completed NCT00338793
18 Procalcitonin in Pleural Pleuritis Completed NCT01011881
19 Drainage of Tuberculous Pleural Effusions Completed NCT00524147
20 Outcome of Patients Undiagnosed Under Medical Thoracoscopy Completed NCT01356979
21 A Trial of Rigid Versus Semirigid Thoracoscopy in the Evaluation of Exudative Pleural Effusions Completed NCT01726556
22 Serum Biomarkers in Diagnosis of Mesothelioma Completed NCT02029105
23 Predictive Factors and Outcome in Medical Thoracoscopy Completed NCT02288065
24 Lung Ultrasound in Pleuritic Chest Pain Completed NCT02107001
25 Extravascular Lung Water Monitoring by Combined Ultrasound and Bioimpedance as a Guide for Treatment in Hemodialysis Patients Completed NCT01815762
26 Efficiency and Safety of Pleural Biopsy Methods in the Diagnosis of Pleural Diseases Completed NCT03153501
27 Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy Completed NCT00720954
28 Detection of Mycoplasma Pneumoniae Completed NCT02511262
29 The Optimization of Mycoplasm Pneumonia Antibiotic Therapy Completed NCT01259141
30 Chlamydia and Mycoplasma in Coronary Artery Disease Completed NCT00561028
31 Randomized Controlled Trial of Doxycycline to Prevent Acquisition of Mycoplasma Pneumoniae in an Outbreak Setting Completed NCT00207584
32 Yield of Cryoprobe vs Flexible Forceps Pleural Biopsy Recruiting NCT02500277
33 Thoracic Ultrasound in the Treatment of Pleural Effusion Recruiting NCT02505763
34 Methylprednisolone for Children With Severe Mycoplasma Pneumoniae Pneumonia (MCMP) Recruiting NCT02303587
35 Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children Terminated NCT01217099

Search NIH Clinical Center for Pleurisy

Genetic Tests for Pleurisy

Anatomical Context for Pleurisy

MalaCards organs/tissues related to Pleurisy:

39
Lung, T Cells, Neutrophil, Testes, Nk Cells, Breast, Monocytes

Publications for Pleurisy

Articles related to Pleurisy:

(show top 50) (show all 571)
id Title Authors Year
1
Calea uniflora Less. attenuates the inflammatory response to carrageenan-induced pleurisy in mice. ( 27912150 )
2017
2
Evaluation of different laboratory methods for rapid diagnosis of tuberculous pleurisy. ( 27931685 )
2016
3
A diagnostic algorithm for tuberculous pleurisy using the ELISPOT assay on peripheral blood and pleural effusion. ( 27187759 )
2016
4
Tissue-infiltrating mucosal-associated invariant T cells play an important role against Mycobacterium tuberculosis infection in tuberculosis pleurisy. ( 27507648 )
2016
5
Role of MCP-1 in pleural effusion development in a carrageenan-induced murine model of pleurisy. ( 27878909 )
2016
6
Dynamic Analysis of Changes of Protein Levels and Selected Biochemical Indices in Rat Serum in the Course of Experimental Pleurisy. ( 27083876 )
2016
7
Anti-inflammatory effect of volatile oil from Schizonepeta tenuifolia on carrageenin-induced pleurisy in rats and its application to study of appropriate harvesting time coupled with multi-attribute comprehensive index method. ( 27765609 )
2016
8
Evaluation of a whole-blood chemiluminescent immunoassay of IFN-I^, IP-10, and MCP-1 for diagnosis of active pulmonary tuberculosis and tuberculous pleurisy patients. ( 27523388 )
2016
9
Analysis of Cytokine Levers in Pleural Effusions of Tuberculous Pleurisy and Tuberculous Empyema. ( 27034588 )
2016
10
Diagnostic accuracy of tumor necrosis factor-alpha assay for tuberculous pleurisy: A PRISMA-compliant meta-analysis. ( 27902616 )
2016
11
Inhibition of the NF-I_B and p38 MAPK pathways by scopoletin reduce the inflammation caused by carrageenan in the mouse model of pleurisy. ( 27324858 )
2016
12
TB/HIV pleurisy reduces Th17 lymphocyte proportion independent of the cytokine microenvironment. ( 27450010 )
2016
13
The anti-inflammatory effect of Ilex paraguariensis A. St. Hil (Mate) in a murine model of pleurisy. ( 27155392 )
2016
14
Are soluble IL-2 receptor and IL-12p40 levels useful markers for diagnosis of tuberculous pleurisy? ( 25549699 )
2015
15
Dry pleurisy complicating solitary pulmonary nodules caused by Mycobacterium avium: a case report. ( 26503229 )
2015
16
Hyaluronic Acid concentration in pleural fluid: diagnostic aid for tuberculous pleurisy. ( 25368701 )
2015
17
Impact of Implementation of an Automated Liquid Culture System on Diagnosis of Tuberculous Pleurisy. ( 26130948 )
2015
18
Accuracy of the interferon-gamma release assay for the diagnosis of tuberculous pleurisy: an updated meta-analysis. ( 26038718 )
2015
19
Diagnostic accuracy of pleural fluid tumor necrosis factor-I+ in tuberculous pleurisy: A meta-analysis. ( 26622262 )
2015
20
Diagnostic Performance of Different Pleural Fluid Biomarkers in Tuberculous Pleurisy. ( 25523627 )
2015
21
The Author's Response: Impact of Implementation of an Automated Liquid Culture System on the Diagnosis of Tuberculous Pleurisy. ( 27099883 )
2015
22
Combined evaluation of adenosine deaminase level and histopathological findings from pleural biopsy with Cope's needle for the diagnosis of tuberculous pleurisy. ( 26261621 )
2015
23
7-prenyloxi-6-methoxycoumarin from Polygala sabulosa A.W. Bennett Regulates p38 MAPK and NF-kB Pathways Inhibiting the Inflammation Induced by Carrageenan in the Mouse Model of Pleurisy. ( 26434700 )
2015
24
Tuberculous pleurisy drives marked effector responses of I^I', CD4+, and CD8+ T cell subpopulations in humans. ( 26156008 )
2015
25
Co-existent Ascariasis and Multiloculated Tuberculous Pleurisy Treated with Intrapleural Streptokinase. ( 26522189 )
2015
26
Epidemiological evaluation of the outcomes after video-assisted thoracoscopic talcage in neoplastic pleurisy. ( 25970953 )
2015
27
Recruitment of IL-27-Producing CD4(+) T Cells and Effect of IL-27 on Pleural Mesothelial Cells in Tuberculous Pleurisy. ( 25944255 )
2015
28
Treatment of free-flowing tuberculous pleurisy with intrapleural urokinase. ( 26467594 )
2015
29
Nicorandil inhibits neutrophil recruitment in carrageenan-induced experimental pleurisy in mice. ( 26607465 )
2015
30
Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats. ( 25616904 )
2015
31
Impact of HIV infection on tuberculosis pleurisy. ( 25957323 )
2015
32
Efficacy of vaccination against Actinobacillus pleuropneumoniae in two Belgian farrow-to-finish pig herds with a history of chronic pleurisy. ( 24552670 )
2014
33
Interferon-gamma immunospot assay of pleural effusion mononuclear cells for diagnosis of tuberculous pleurisy. ( 24391138 )
2014
34
Polygala molluginifolia A. St.-Hil. and Moq. prevent inflammation in the mouse pleurisy model by inhibiting NF-I_B activation. ( 24560858 )
2014
35
Proteinase-activated receptor 2 blockade impairs CCL11- or allergen-induced eosinophil recruitment in experimental pleurisy. ( 24972241 )
2014
36
Campylobacter fetus bacteremia with purulent pleurisy in a young adult with primary hypogammaglobulinemia. ( 24881753 )
2014
37
Role of a histamine 4 receptor as an anti-inflammatory target in carrageenan-induced pleurisy in mice. ( 24460575 )
2014
38
Factors influencing pleural adenosine deaminase level in patients with tuberculous pleurisy. ( 24762755 )
2014
39
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) preceding tuberculous pleurisy. ( 24576282 )
2014
40
IL-33 levels differentiate tuberculous pleurisy from malignant pleural effusions. ( 24959294 )
2014
41
Tuberculous pleurisy: an update. ( 24851127 )
2014
42
Costunolide and Dehydrocostuslactone, two natural sesquiterpene lactones, ameliorate the inflammatory process associated to experimental pleurisy in mice. ( 24625594 )
2014
43
The changes and its significance of Th17 and Treg cells and related cytokines in patients with tuberculosis pleurisy. ( 25089129 )
2014
44
BCG-induced pneumonitis with lymphocytic pleurisy in the absence of elevated KL-6. ( 24593234 )
2014
45
A case of pleural paragonimiasis confused with tuberculous pleurisy. ( 24851131 )
2014
46
Treatment of consecutive episodes of multidrug-resistant bacterial pleurisy with different aetiology in a heart transplant candidate: proof of concept of pharmacokinetic/pharmacodynamic optimisation of antimicrobial therapy at the infection site. ( 25305146 )
2014
47
Diagnosis of tuberculosis pleurisy with adenosine deaminase (ADA): a systematic review and meta-analysis. ( 25419343 )
2014
48
Jungia sellowii suppresses the carrageenan-induced inflammatory response in the mouse model of pleurisy. ( 25168307 )
2014
49
Mycobacterium tuberculosis-specific memory NKT cells in patients with tuberculous pleurisy. ( 25190196 )
2014
50
Indicaxanthin from cactus pear fruit exerts anti-inflammatory effects in carrageenin-induced rat pleurisy. ( 24306215 )
2014

Variations for Pleurisy

Expression for Pleurisy

Search GEO for disease gene expression data for Pleurisy.

Pathways for Pleurisy

Pathways related to Pleurisy according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 ALOX5 CCL2 CRP CXCL8 ICAM1 IFNG
2
Show member pathways
13.6 ALOX5 CCL2 CXCL8 IFNG IL2 TGFB1
3
Show member pathways
13.49 CCL2 CXCL8 ICAM1 IFNG IL2 TGFB1
4
Show member pathways
13.3 ALOX5 CCL2 CXCL8 ICAM1 IFNG IL2
5
Show member pathways
12.89 CCL2 CXCL8 IFNG IL2 TGFB1 TNF
6
Show member pathways
12.83 CXCL8 ICAM1 IFNG IL2 TGFB1 TNF
7
Show member pathways
12.77 CCL2 CXCL8 ICAM1 IFNG IL2 TNF
8
Show member pathways
12.58 CCL2 IFNG IL2 MPO TNF
9
Show member pathways
12.56 IFNG IL2 TGFB1 TNF
10 12.51 ALOX5 CCL2 IFNG IL2 MPO TNF
11
Show member pathways
12.49 ICAM1 IFNG IL2 TNF
12
Show member pathways
12.41 IFNG IL2 TGFB1 TNF
13 12.4 ICAM1 IL2 TGFB1 TNF
14
Show member pathways
12.32 CCL2 CXCL8 IFNG TNF
15
Show member pathways
12.25 ALOX5 IFNG TGFB1 TNF
16
Show member pathways
12.15 CXCL8 IFNG IL2 TNF
17 12.09 CCL2 ICAM1 IFNG TNF
18 12.01 IFNG TGFB1 TNF
19 11.96 IFNG IL2 MPO SELL TNF
20
Show member pathways
11.95 IFNG IL2 TGFB1 TNF
21 11.93 CCL2 ICAM1 TNF
22 11.92 CXCL8 IFNG TGFB1
23 11.9 CXCL8 IFNG TGFB1 TNF
24 11.87 CXCL8 ICAM1 TNF
25 11.86 ALOX5 CCL2 CXCL8 ICAM1 TGFB1 TNF
26 11.85 CXCL8 IL2 TGFB1
27
Show member pathways
11.85 CXCL8 ICAM1 TGFB1
28 11.85 CCL2 CXCL8 ICAM1 TGFB1 TNF
29 11.81 CXCL8 ICAM1 IFNG IL2
30 11.8 IFNG TGFB1 TNF
31 11.78 IFNG IL2 TNF
32 11.78 CCL2 CXCL8 ICAM1 IFNG IL2 TGFB1
33
Show member pathways
11.76 CXCL8 IFNG IL2 TNF
34 11.71 ICAM1 TGFB1 TNF
35 11.71 IFNG IL2 SELL TGFB1 TNF
36 11.69 CCL2 CXCL8 ICAM1 IFNG TGFB1 TNF
37 11.68 IFNG IL2 TGFB1
38 11.67 CCL2 CXCL8 TGFB1 TNF
39
Show member pathways
11.65 IFNG IL2 TNF
40 11.62 IFNG TGFB1 TNF
41
Show member pathways
11.6 CXCL8 ICAM1 IFNG IL2 TNF
42 11.56 IFNG IL2 TNF
43
Show member pathways
11.56 ALOX5 CCL2 CRP ICAM1 IFNG IL2
44 11.55 CCL2 CXCL8 ICAM1 TNF
45 11.53 IFNG IL2 TGFB1 TNF
46 11.52 ICAM1 MPO TNF
47 11.52 CCL2 IFNG TNF
48 11.48 CXCL8 ICAM1 IFNG
49
Show member pathways
11.43 IFNG IL2 TGFB1 TNF
50 11.37 ICAM1 IFNG TNF

GO Terms for Pleurisy

Cellular components related to Pleurisy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 ALOX5 CCL2 CRP CXCL8 IFNG IL2
2 cell surface GO:0009986 9.65 ADA ICAM1 SELL TGFB1 TNF
3 extracellular space GO:0005615 9.36 ADA ALOX5 CCL2 CRP CXCL8 ICAM1
4 external side of plasma membrane GO:0009897 9.35 ADA ICAM1 IFNG SELL TNF

Biological processes related to Pleurisy according to GeneCards Suite gene sharing:

(show all 50)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.98 CRP IFNG TGFB1 TNF
2 MAPK cascade GO:0000165 9.94 CCL2 IL2 TGFB1 TNF
3 leukocyte migration GO:0050900 9.92 ICAM1 SELL TGFB1 TNF
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.89 CCL2 ICAM1 TGFB1 TNF
5 cell cycle arrest GO:0007050 9.88 CXCL8 IFNG TGFB1
6 defense response GO:0006952 9.88 CXCL8 MPO TNF
7 aging GO:0007568 9.88 ADA CCL2 MPO TGFB1
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 ICAM1 TGFB1 TNF
9 response to ethanol GO:0045471 9.87 CCL2 ICAM1 IL2
10 response to hypoxia GO:0001666 9.87 ADA CCL2 ICAM1 TGFB1
11 cellular response to tumor necrosis factor GO:0071356 9.86 CCL2 CXCL8 ICAM1
12 positive regulation of protein phosphorylation GO:0001934 9.84 IFNG IL2 TGFB1 TNF
13 negative regulation of inflammatory response GO:0050728 9.83 ADA IL2 MEFV
14 response to drug GO:0042493 9.83 ADA CCL2 ICAM1 IFNG TGFB1
15 cellular response to interleukin-1 GO:0071347 9.81 CCL2 CXCL8 ICAM1
16 cellular response to organic cyclic compound GO:0071407 9.81 CCL2 TGFB1 TNF
17 neutrophil chemotaxis GO:0030593 9.8 CCL2 CXCL8 IFNG
18 humoral immune response GO:0006959 9.78 CCL2 IFNG TNF
19 positive regulation of cell adhesion GO:0045785 9.77 CCL2 IFNG TNF
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 ICAM1 IFNG TNF
21 extrinsic apoptotic signaling pathway GO:0097191 9.72 IFNG TGFB1 TNF
22 negative regulation of myoblast differentiation GO:0045662 9.71 TGFB1 TNF
23 positive regulation of osteoclast differentiation GO:0045672 9.7 IFNG TNF
24 cellular response to interleukin-6 GO:0071354 9.7 CCL2 ICAM1
25 positive regulation of T cell differentiation GO:0045582 9.69 ADA IL2
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IFNG TNF
27 positive regulation of interleukin-17 production GO:0032740 9.68 IL2 TGFB1
28 PERK-mediated unfolded protein response GO:0036499 9.68 CCL2 CXCL8
29 negative regulation of interleukin-17 production GO:0032700 9.67 IFNG TGFB1
30 positive regulation of regulatory T cell differentiation GO:0045591 9.67 IL2 TGFB1
31 cellular response to dexamethasone stimulus GO:0071549 9.67 CCL2 ICAM1 TGFB1
32 positive regulation of superoxide anion generation GO:0032930 9.66 CRP TGFB1
33 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IFNG TNF
34 positive regulation of isotype switching to IgG isotypes GO:0048304 9.65 IFNG IL2
35 negative regulation of lipid storage GO:0010888 9.65 CRP TNF
36 protein kinase B signaling GO:0043491 9.65 CCL2 TGFB1 TNF
37 positive regulation of cellular extravasation GO:0002693 9.63 CCL2 ICAM1
38 lipopolysaccharide-mediated signaling pathway GO:0031663 9.63 CCL2 TGFB1 TNF
39 positive regulation of mononuclear cell migration GO:0071677 9.58 TGFB1 TNF
40 protein import into nucleus, translocation GO:0000060 9.54 IFNG TGFB1 TNF
41 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.52 ICAM1 TNF
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 IFNG TNF
43 positive regulation of protein complex assembly GO:0031334 9.5 IFNG TGFB1 TNF
44 embryonic digestive tract development GO:0048566 9.43 ADA CXCL8 TNF
45 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 IFNG TNF
46 cellular response to lipopolysaccharide GO:0071222 9.35 CCL2 CXCL8 ICAM1 IFNG TNF
47 negative regulation of growth of symbiont in host GO:0044130 9.33 IFNG MPO TNF
48 inflammatory response GO:0006954 9.17 ALOX5 CCL2 CRP CXCL8 MEFV TGFB1
49 cell adhesion GO:0007155 10.07 ADA CCL2 ICAM1 IL2 SELL
50 immune response GO:0006955 10.01 CCL2 CXCL8 IFNG IL2 TNF

Molecular functions related to Pleurisy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IFNG IL2 TGFB1 TNF
2 glycosphingolipid binding GO:0043208 8.96 IL2 SELL

Sources for Pleurisy

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
16 ExPASy
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28 GO
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30 HGMD
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33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
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54 OMIM
55 OMIM via Orphanet
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60 QIAGEN
65 SNOMED-CT via Orphanet
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68 Tocris
69 UMLS
70 UMLS via Orphanet
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