MCID: PLX002
MIFTS: 41

Plexiform Neurofibroma malady

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Plexiform Neurofibroma

Aliases & Descriptions for Plexiform Neurofibroma:

Name: Plexiform Neurofibroma 12 29 14 69
Neurofibroma, Plexiform 42
Neurofibroma Plexiform 52

Classifications:



External Ids:

Disease Ontology 12 DOID:5151
MeSH 42 D018318
NCIt 47 C3797
SNOMED-CT 64 403818001 41252002
UMLS 69 C0206728

Summaries for Plexiform Neurofibroma

MalaCards based summary : Plexiform Neurofibroma, also known as neurofibroma, plexiform, is related to neurofibroma and neurofibromatosis. An important gene associated with Plexiform Neurofibroma is NF1 (Neurofibromin 1), and among its related pathways/superpathways are Cell cycle_Role of APC in cell cycle regulation and Interaction between L1 and Ankyrins. The drugs Doxorubicin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, bone and tongue, and related phenotypes are behavior/neurological and respiratory system

Related Diseases for Plexiform Neurofibroma

Diseases related to Plexiform Neurofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
id Related Disease Score Top Affiliating Genes
1 neurofibroma 11.0
2 neurofibromatosis 10.7
3 neurofibromatosis, type 1 10.5
4 malignant peripheral nerve sheath tumor 10.2
5 watson syndrome 10.2 NF1 NF2
6 lateral medullary syndrome 10.2 NF1 NF2
7 anorectal stricture 10.2 NF1 NF2
8 jejunal somatostatinoma 10.2 NF1 NF2
9 monckeberg arteriosclerosis 10.2 NF1 NF2
10 epilepsy, familial focal, with variable foci 10.2 NF1 NF2
11 childhood vagina botryoid rhabdomyosarcoma 10.2 NF1 NF2
12 diphtheria 10.2 NF1 NF2
13 vascular myelopathy 10.2 NF1 NF2
14 epidural abscess 10.1 NF1 NF2
15 pharynx cancer 10.1 NF1 NF2
16 granulomatous myositis 10.1 NF1 NF2
17 surfactant metabolism dysfunction, pulmonary, 5 10.1 NF1 NF2
18 pineal dysgerminoma 10.1 NF1 NF2
19 c-p angle neurinoma 10.1 NF1 NF2
20 endocrine organ benign neoplasm 10.1 NF1 NF2
21 occlusion precerebral artery 10.1 NF1 NF2
22 connective tissue cancer 10.0 ANK3 NF2
23 chromosome 15q11-q13 duplication syndrome 10.0 NF1 SPRED1
24 postmenopausal atrophic vaginitis 10.0 NF1 NF2
25 nephrolithiasis 10.0 NF1 SPRED1
26 cardiomyopathy, dilated, 1r 10.0 NF1 SPRED1
27 neurofibromatosis-noonan syndrome 10.0 NF1 SPRED1
28 hepatitis 10.0
29 cervicitis 10.0
30 autosomal genetic disease 9.9 NF1 NF2
31 choroiditis 9.9
32 laryngitis 9.9
33 ganglioneuroma 9.9
34 glioma 9.9
35 seborrheic dermatitis 9.9 NF1 NF2 SPRED1
36 pathologic nystagmus 9.8 ANK3 NEK2 NF1 NF2
37 otitis media 9.8
38 neurofibromatosis, type 2 9.8
39 lipoma 9.8
40 myasthenia gravis 9.8
41 sacrococcygeal teratoma 9.8
42 angiosarcoma 9.8
43 oculocutaneous albinism 9.8
44 scoliosis 9.8
45 ptosis 9.8
46 amblyopia 9.8
47 portal hypertension 9.8
48 meningocele 9.8
49 buphthalmos 9.8
50 myopia 9.8

Graphical network of the top 20 diseases related to Plexiform Neurofibroma:



Diseases related to Plexiform Neurofibroma

Symptoms & Phenotypes for Plexiform Neurofibroma

MGI Mouse Phenotypes related to Plexiform Neurofibroma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 ANK3 BUB1B NF1 NF2 SPRED1 SPTBN2
2 respiratory system MP:0005388 9.02 ANK3 BUB1B NF1 NF2 SPRED1

Drugs & Therapeutics for Plexiform Neurofibroma

Drugs for Plexiform Neurofibroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved Phase 2, Phase 3 51-75-2 4033
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6 Anti-Bacterial Agents Phase 2, Phase 3
7 Antibiotics, Antitubercular Phase 2, Phase 3
8 Alkylating Agents Phase 2, Phase 3
9 Topoisomerase Inhibitors Phase 2, Phase 3
10 Isophosphamide mustard Phase 2, Phase 3
11 Antineoplastic Agents, Alkylating Phase 2, Phase 3
12
Vinblastine Approved Phase 2 865-21-4 13342 241903
13
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
14
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
15
Everolimus Approved Phase 2 159351-69-6 6442177
16
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
17
Peginterferon alfa-2b Approved Phase 2,Phase 1 99210-65-8, 215647-85-1
18
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
19
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
20
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
21
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
22
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
24
tipifarnib Investigational Phase 2 192185-72-1 159324
25
Pirfenidone Investigational Phase 2,Phase 1 53179-13-8 40632
26
Cediranib Investigational Phase 2 288383-20-0 9933475
27
Maleic acid Experimental Phase 2 110-16-7 444266
28 Imatinib Mesylate Phase 2,Phase 1 123596
29 interferons Phase 2,Phase 1
30 Analgesics Phase 2,Phase 1
31 Folic Acid Antagonists Phase 2
32 Nucleic Acid Synthesis Inhibitors Phase 2
33 Analgesics, Non-Narcotic Phase 2,Phase 1
34 Dermatologic Agents Phase 2,Phase 1
35 Peripheral Nervous System Agents Phase 2,Phase 1
36 Angiogenesis Inhibitors Phase 2,Phase 1
37 Vitamin B Complex Phase 2
38 Pharmaceutical Solutions Phase 2,Phase 1
39 Anti-Infective Agents Phase 2,Phase 1
40 Immunosuppressive Agents Phase 2
41 Protein Kinase Inhibitors Phase 2,Phase 1
42 Anti-Inflammatory Agents Phase 2,Phase 1
43 Interferon-alpha Phase 2,Phase 1
44 Antifungal Agents Phase 2
45 Anti-Inflammatory Agents, Non-Steroidal Phase 2,Phase 1
46 Antimetabolites Phase 2
47 Antimetabolites, Antineoplastic Phase 2
48 Antimitotic Agents Phase 2
49 Antirheumatic Agents Phase 2,Phase 1
50 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:

(show all 40)
id Name Status NCT ID Phase
1 Acceptance and Commitment Training for Adolescents and Young Adults With Neurofibromatosis Type 1, Plexiform Neurofibromas, and Chronic Pain Recruiting NCT02471339 Phase 3
2 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
3 Pirfenidone in Children and Young Adults With Neurofibromatosis Type I and Progressive Plexiform Neurofibromas Completed NCT00076102 Phase 2
4 R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas Completed NCT00021541 Phase 2
5 Study of PEG-Intron for Plexiform Neurofibromas Completed NCT00396019 Phase 2
6 Use of RAD001 as Monotherapy in the Treatment of Neurofibromatosis 1 Related Internal Plexiform Neurofibromas Completed NCT01412892 Phase 2
7 A Phase II Study of the mTOR Inhibitor Sirolimus in Neurofibromatosis Type 1 Related Plexiform Neurofibromas Completed NCT00634270 Phase 2
8 Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform Neurofibromas Completed NCT00030264 Phase 2
9 Phase II Study of Gleevec/Imatinib Mesylate (STI-571, NCS 716051) in Neurofibromatosis (NF1) Patients With Plexiform Neurofibromas Completed NCT01673009 Phase 2
10 Clinical Trial of Pirfenidone in Adult Patients With Neurofibromatosis 1 Completed NCT00754780 Phase 2
11 Study of Imatinib Mesylate in Neurofibromatosis Type I Patients Aged 2 to 21 With Plexiform Neurofibromas Recruiting NCT02177825 Phase 2
12 Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibromas That Cannot Be Removed by Surgery Recruiting NCT02407405 Phase 2
13 PLX3397 in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) Recruiting NCT02390752 Phase 1, Phase 2
14 AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors Recruiting NCT01362803 Phase 1, Phase 2
15 Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in People With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST) Recruiting NCT03109301 Phase 2
16 Pilot Study of Gleevec/Imatinib Mesylate (STI-571, NSC 716051) in Neurofibromatosis (NF1) Patient With Plexiform Neurofibromas Active, not recruiting NCT01140360 Phase 1, Phase 2
17 Cabozantinib for Plexiform Neurofibromas (PN) in Subjects With NF1 (16 Years +) Active, not recruiting NCT02101736 Phase 2
18 AZD2171 in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibroma and/or Neurofibroma Near the Spine Active, not recruiting NCT00326872 Phase 2
19 MEK Inhibitor PD-0325901 Trial in Adolescents and Adults With NF1 Active, not recruiting NCT02096471 Phase 2
20 Medical Treatment of "High-Risk" Neurofibromas Active, not recruiting NCT00846430 Phase 2
21 Study of Sutent®/Sunitinib (SU11248) in Subjects With NF-1 Plexiform Neurofibromas Suspended NCT01402817 Phase 2
22 Efficacy and Safety of RAD001 in Treating Plexiform Neurofibromas (PN) Associated With Neurofibromatosis (NF1) Terminated NCT01365468 Phase 2
23 Sorafenib to Treat Children and Young Adults With Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas Completed NCT00727233 Phase 1
24 Pirfenidone in Treating Young Patients With Neurofibromatosis Type 1 and Plexiform Neurofibromas Completed NCT00053937 Phase 1
25 PEG-Interferon Alfa-2b in Treating Young Patients With Plexiform Neurofibroma Completed NCT00253474 Phase 1
26 Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations Recruiting NCT02124772 Phase 1
27 Phase I Clinical Study of the Safety of Photodynamic Therapy (PDT) Using LS11 in Children With Plexiform Neurofibromas Terminated NCT00716469 Phase 1
28 Whole Body Magnetic Resonance Imaging With Diffusion Weighted Imaging : Potential Role in Neurofibromatosis Unknown status NCT01777451
29 Analysis of Peripheral Nerve Sheath Tumors (PNSTs) in Neurofibromatosis Type 1 (NF1) Patients Unknown status NCT01218139
30 Study of Plexiform Neurofibromas in Neurofibromatosis Type 1 Completed NCT00006435
31 Study of Tasigna®/Nilotinib (AMN107) in Neurofibromatosis (NF1) Patients With Plexiform Neurofibromas Completed NCT01275586 Early Phase 1
32 Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development Completed NCT00340522
33 Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (PNs) Recruiting NCT02544022
34 Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1 Recruiting NCT02211768 Early Phase 1
35 Natural History Study of Patients With Neurofibromatosis Type I Recruiting NCT00924196
36 Targeting the Mechanisms Underlying Cutaneous Neurofibroma Formation in NF1: A Clinical Translational Approach. Recruiting NCT02777775
37 Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors Recruiting NCT03141021
38 PET/MRI in CNS and Extra-CNS Tumors of Patients With Neurofibromatosis-1 (NF1) Active, not recruiting NCT01800032
39 Clinical Sequencing of Cancer and Tissue Repository: ClinOmics Not yet recruiting NCT03027401
40 Fludeoxyglucose F 18 Positron Emission Tomography and Magnetic Resonance Perfusion Imaging in Patients With Neurofibromatosis 1 and Plexiform Neurofibroma Terminated NCT00060008

Search NIH Clinical Center for Plexiform Neurofibroma

Cochrane evidence based reviews: neurofibroma, plexiform

Genetic Tests for Plexiform Neurofibroma

Genetic tests related to Plexiform Neurofibroma:

id Genetic test Affiliating Genes
1 Plexiform Neurofibroma 29

Anatomical Context for Plexiform Neurofibroma

MalaCards organs/tissues related to Plexiform Neurofibroma:

39
Salivary Gland, Bone, Tongue, Skin, Liver, Dorsal Root Ganglion, Trigeminal Ganglion

Publications for Plexiform Neurofibroma

Articles related to Plexiform Neurofibroma:

(show top 50) (show all 294)
id Title Authors Year
1
The primacy of NF1 loss as the driver of tumorigenesis in neurofibromatosis type 1-associated plexiform neurofibromas. ( 28068329 )
2017
2
Magnetic resonance neurographic confirmation of extensive Plexiform neurofibroma in neurofibromatosis-1 presenting as ambiguous genitalia. ( 27857458 )
2016
3
Improvement of hyperpigmentation within a plexiform neurofibroma after treatment with Q-switched neodymium:yttrium-aluminium-garnet laser. ( 26880255 )
2016
4
Initial Exploration on Temporal Branch of Facial Nerve Function Preservation in Plexiform Neurofibroma Resection. ( 27526236 )
2016
5
The Role of [(18)F]FDG-PET/CT in Predicting Malignant Transformation of Plexiform Neurofibromas in Neurofibromatosis-1. ( 28058117 )
2016
6
Dual mTORC1/2 inhibition induces anti-proliferative effect in NF1-associated plexiform neurofibroma and malignant peripheral nerve sheath tumor cells. ( 26840085 )
2016
7
Misdiagnosis of plexiform neurofibroma as venous malformation in pediatric patients. ( 26868134 )
2016
8
Solitary Non Syndromic Oral Plexiform Neurofibroma: a Case Report and Review of Literature. ( 27840843 )
2016
9
Plexiform Neurofibroma: A Case Report. ( 26871793 )
2016
10
Plexiform neurofibroma. ( 27824540 )
2016
11
A case of portal hypertension by presumed as plexiform neurofibroma at the hepatic hilum. ( 27209645 )
2016
12
Isolated plexiform neurofibroma mimicking a vascular lesion. ( 27192529 )
2016
13
Unusual location of a plexiform neurofibroma in the fallopian tube: A case report. ( 27641440 )
2016
14
Sphenoid wing dysplasia and plexiform neurofibroma in neurofibromatosis type 1. ( 27061833 )
2016
15
Multifactorial pathological hip subluxation in neurofibromatosis type-1 (NF1) due to intra-articular plexiform neurofibroma, lumbar radiculopathy and neurofibromatous polyneuropathy. ( 27932436 )
2016
16
Multivacuolated mucin-filled cells: a unique cell characteristic of plexiform neurofibroma. A report of 11 cases. ( 27816720 )
2016
17
Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas. ( 28029918 )
2016
18
Genetic basis of a solitary familial plexiform neurofibroma without verified associated neurofibromatosis. ( 27119482 )
2016
19
Ipsilateral Sphenoid Wing Dysplasia, Orbital Plexiform Neurofibroma and Fronto-Parietal Dermal Cylindroma in a Patient with Segmental Neurofibromatosis. ( 26637901 )
2015
20
Infant With a Unilateral Parotid Mass, Recurrent Otitis Media, and Macrocephaly. Plexiform neurofibroma. ( 26237456 )
2015
21
Massive Plexiform Neurofibroma of the Neck and Larynx. ( 26491483 )
2015
22
Preclinical assessment of the anticancer drug response of plexiform neurofibroma tissue using primary cultures. ( 25851896 )
2015
23
Hybrid resection of a giant thigh plexiform neurofibroma. ( 25603483 )
2015
24
Management of an expansile orbital mass: Plexiform neurofibroma decompression by orbitozygomatic approach. ( 25960281 )
2015
25
Giant cell tumor of the tendon sheath mimicking a plexiform neurofibroma. ( 26009718 )
2015
26
Isolated plexiform neurofibroma of arm with unusual presentation - a rare case report. ( 25738048 )
2015
27
Partially Plexiform Neurofibroma of the Labia Minora and Clitoral Hood-A Prognostic Dilemma. ( 25658713 )
2015
28
SRU Cases of the Day: Plexiform Neurofibroma. ( 26561219 )
2015
29
Oral manifestations of neurofibromatosis type 1 in children with facial plexiform neurofibroma: report of three cases. ( 25823487 )
2015
30
Plexiform Neurofibroma of the Penis and Facial Nerve. ( 25303261 )
2014
31
Plexiform neurofibroma treated with pharmacopuncture. ( 25780713 )
2014
32
Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma. ( 25446898 )
2014
33
Choroidal Ganglioneuroma and Orbital Plexiform Neurofibroma Presenting as Buphthalmos in an Infant With Neurofibromatosis Type 1. ( 25186217 )
2014
34
An unusual combination of unilateral orbital plexiform neurofibroma in a patient with oculocutaneous albinism. ( 25005209 )
2014
35
Nilotinib is more potent than imatinib for treating plexiform neurofibroma in vitro and in vivo. ( 25340526 )
2014
36
Clinical and radiological repercussions of plexiform neurofibroma in the pelvic region. ( 25741110 )
2014
37
Solitary parotid plexiform neurofibroma - diagnostic difficulty in a clinically unsuspected case. ( 25494144 )
2014
38
Plexiform neurofibroma of uterus: a rare manifestation of neurofibromatosis 1. ( 24717994 )
2014
39
Solitary plexiform neurofibroma of the stomach: a case report. ( 24803834 )
2014
40
Extensive Plexiform Neurofibroma in a Premature Neonate. ( 25380612 )
2014
41
Misdiagnosis of plexiform neurofibroma of the medial plantar nerve: case report. ( 25024003 )
2014
42
Co-occurrence of choroidal pigmented ganglioneuroma and plexiform neurofibroma in a patient with neurofibromatosis 1. ( 24656164 )
2014
43
Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a Neurofibromatosis Clinical Trials Consortium phase II study. ( 25314964 )
2014
44
Isolated plexiform neurofibroma of the tongue. ( 24701108 )
2013
45
Phase I trial and pharmacokinetic study of sorafenib in children with neurofibromatosis type I and plexiform neurofibromas. ( 22961690 )
2013
46
Giant plexiform neurofibroma causing asymptomatic cervical spinal cord compression in a child with neurofibromatosis type 1. ( 23625679 )
2013
47
Radiosurgical treatment of ulnar plexiform neurofibroma in a neurofibromatosis type 1 (NF1) patient. ( 23307331 )
2013
48
Visual outcomes in children with neurofibromatosis type 1 and orbitotemporal plexiform neurofibromas. ( 23453281 )
2013
49
Plexiform neurofibroma in an 8 year-old patient. ( 22436367 )
2013
50
Re: 'Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: An uncommon cause of severe urological disease in an infant' J Pediatr Urol 2013 Feb 4 [Epub ahead of print]. ( 23973761 )
2013

Variations for Plexiform Neurofibroma

Copy number variations for Plexiform Neurofibroma from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 109397 17 25800000 31800000 Deletion NF1 Plexiform neurofibroma
2 109445 17 26082 26121 Microdeletion SUZ12 Plexiform neurofibroma
3 109456 17 26183 26246 Microdeletion ATAD5 Plexiform neurofibroma
4 109470 17 26273 26310 Microdeletion CENTA2 Plexiform neurofibroma
5 109475 17 26322 26351 Microdeletion RNF135 Plexiform neurofibroma
6 109535 17 26645 26648 Microdeletion OMG Plexiform neurofibroma
7 109543 17 26668 26672 Microdeletion EVI2A Plexiform neurofibroma
8 109598 17 27203 27210 Microdeletion C17orf79 Plexiform neurofibroma

Expression for Plexiform Neurofibroma

Search GEO for disease gene expression data for Plexiform Neurofibroma.

Pathways for Plexiform Neurofibroma

Pathways related to Plexiform Neurofibroma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.69 BUB1B NEK2
2 10.1 ANK3 SPTBN2

GO Terms for Plexiform Neurofibroma

Cellular components related to Plexiform Neurofibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.5 ANK3 BUB1B NEK2 NF1 NF2 SPRED1
2 cytoskeleton GO:0005856 9.02 ANK3 BUB1B NEK2 NF2 SPTBN2

Biological processes related to Plexiform Neurofibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.33 NF1 SPRED1 SPTBN2
2 negative regulation of MAPK cascade GO:0043409 8.96 NF1 NF2
3 negative regulation of cell-matrix adhesion GO:0001953 8.62 NF1 NF2

Molecular functions related to Plexiform Neurofibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoskeletal protein binding GO:0008092 8.62 ANK3 NF2

Sources for Plexiform Neurofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
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54 OMIM
55 OMIM via Orphanet
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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