MCID: PLX002
MIFTS: 40

Plexiform Neurofibroma

Categories: Neuronal diseases, Cancer diseases

Aliases & Classifications for Plexiform Neurofibroma

MalaCards integrated aliases for Plexiform Neurofibroma:

Name: Plexiform Neurofibroma 12 28 14 69
Neurofibroma, Plexiform 41
Neurofibroma Plexiform 51

Classifications:



External Ids:

Disease Ontology 12 DOID:5151
MeSH 41 D018318
NCIt 46 C3797
SNOMED-CT 64 403818001 41252002
UMLS 69 C0206728

Summaries for Plexiform Neurofibroma

MalaCards based summary : Plexiform Neurofibroma, also known as neurofibroma, plexiform, is related to neurofibroma and neurofibromatosis, type iv, of riccardi. An important gene associated with Plexiform Neurofibroma is NF1 (Neurofibromin 1), and among its related pathways/superpathways is Cell cycle_Role of APC in cell cycle regulation. The drugs Celecoxib and Peginterferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, bone and tongue, and related phenotype is respiratory system.

Related Diseases for Plexiform Neurofibroma

Diseases related to Plexiform Neurofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 neurofibroma 31.9 NF1 NF2
2 neurofibromatosis, type iv, of riccardi 31.2 NF1 NF2
3 malignant peripheral nerve sheath tumor 30.1 NF1 NF2
4 cellular schwannoma 30.1 NF1 NF2
5 neuroma 29.8 ANK3 NF2
6 neurofibromatosis, type i 10.4
7 neurofibromatosis, familial spinal 10.3 NF1 NF2
8 neurofibrosarcoma 10.3 NF1 NF2
9 plexiform schwannoma 10.3 NF1 NF2
10 immature cataract 10.3 NF1 NF2
11 atypical neurofibroma 10.3 NF1 NF2
12 amyloid tumor 10.3 NF1 NF2
13 spinal canal and spinal cord meningioma 10.3 NF1 NF2
14 neurilemmomatosis 10.2 NF1 NF2
15 spinal meningioma 10.2 NF1 NF2
16 optic nerve neoplasm 10.2 NF1 NF2
17 spinal cord ependymoma 10.2 NF1 NF2
18 hepatitis 10.2
19 neurofibromatosis, type ii 10.2 NF1 NF2
20 neurilemmoma 10.2 NF1 NF2
21 cervicitis 10.2
22 organ system benign neoplasm 10.2 NF1 NF2
23 peripheral nervous system neoplasm 10.1 NF1 NF2
24 nervous system cancer 10.1 NF1 NF2
25 autosomal genetic disease 10.1 NF1 NF2
26 carpal tunnel syndrome 10.0
27 mononeuropathy of the median nerve, mild 10.0
28 episodic pain syndrome, familial, 1 10.0
29 choroiditis 10.0
30 laryngitis 10.0
31 ganglioneuroma 10.0
32 glioma 10.0
33 autosomal dominant café au lait spots 10.0 NF1 SPRED1
34 legius syndrome 9.9 NF1 SPRED1
35 autosomal dominant disease 9.9 NF1 NF2
36 leopard syndrome 9.9 NF1 SPRED1
37 hair whorl 9.9
38 lipomatosis, multiple 9.9
39 otitis media 9.9
40 pectus excavatum 9.9
41 dowling-degos disease 1 9.9
42 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
43 glaucoma 3, primary congenital, a 9.9
44 hemangiopericytoma, malignant 9.9
45 myasthenia gravis 9.9
46 aging 9.9
47 gastrointestinal stromal tumor 9.9
48 meningioma, familial 9.9
49 sacrococcygeal teratoma 9.9
50 angiosarcoma 9.9

Graphical network of the top 20 diseases related to Plexiform Neurofibroma:



Diseases related to Plexiform Neurofibroma

Symptoms & Phenotypes for Plexiform Neurofibroma

MGI Mouse Phenotypes related to Plexiform Neurofibroma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.02 ANK3 BUB1B NF1 NF2 SPRED1

Drugs & Therapeutics for Plexiform Neurofibroma

Drugs for Plexiform Neurofibroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
2
Peginterferon alfa-2b Approved Phase 2,Phase 1 215647-85-1, 99210-65-8
3
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
4
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
5
Everolimus Approved Phase 2 159351-69-6 6442177
6
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
7
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
8
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
9
Vinblastine Approved Phase 2 865-21-4 241903 13342
10
Pirfenidone Approved, Investigational Phase 2,Phase 1 53179-13-8 40632
11
Trametinib Approved Phase 1, Phase 2 871700-17-3 11707110
12
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
14
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
15
tipifarnib Investigational Phase 2 192185-72-1 159324
16
Cediranib Investigational Phase 2 288383-20-0 9933475
17
Maleic acid Experimental Phase 2 110-16-7 444266
18 Alkylating Agents Phase 2
19 Analgesics Phase 2,Phase 1
20 Analgesics, Non-Narcotic Phase 2,Phase 1
21 Anti-Infective Agents Phase 2,Phase 1
22 Anti-Inflammatory Agents Phase 2,Phase 1
23 Anti-Inflammatory Agents, Non-Steroidal Phase 2,Phase 1
24 Antimitotic Agents Phase 2
25 Antineoplastic Agents, Phytogenic Phase 2
26 Antirheumatic Agents Phase 2,Phase 1
27 Antiviral Agents Phase 2,Phase 1
28 Cyclooxygenase 2 Inhibitors Phase 2
29 Cyclooxygenase Inhibitors Phase 2
30 Interferon-alpha Phase 2,Phase 1
31 interferons Phase 2,Phase 1
32 Peripheral Nervous System Agents Phase 2,Phase 1
33 Anti-Bacterial Agents Phase 2
34 Antibiotics, Antitubercular Phase 2
35 Antifungal Agents Phase 2
36 Immunosuppressive Agents Phase 2
37 Pharmaceutical Solutions Phase 2,Phase 1
38 Antimetabolites Phase 2
39 Antimetabolites, Antineoplastic Phase 2
40 Dermatologic Agents Phase 2,Phase 1
41 Folic Acid Antagonists Phase 2
42 Nucleic Acid Synthesis Inhibitors Phase 2
43 Vitamin B Complex Phase 2
44 Imatinib Mesylate Phase 2,Phase 1 123596
45 Protein Kinase Inhibitors Phase 2,Phase 1
46 Angiogenesis Inhibitors Phase 2,Phase 1
47 Mitogens Phase 1, Phase 2
48 Angiogenesis Modulating Agents Phase 2
49 Folate Nutraceutical Phase 2
50 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:

(show all 41)

# Name Status NCT ID Phase Drugs
1 Acceptance and Commitment Training for Adolescents and Young Adults With Neurofibromatosis Type 1, Plexiform Neurofibromas, and Chronic Pain Recruiting NCT02471339 Phase 3
2 Medical Treatment of "High-Risk" Neurofibromas Unknown status NCT00846430 Phase 2 Peg-Interferon alpha-2b;Celecoxib (Celebrex);Temozolomide (temodar);Vincristine Sulfate (Oncovin)
3 Study of PEG-Intron for Plexiform Neurofibromas Completed NCT00396019 Phase 2 PEG-Intron
4 Use of RAD001 as Monotherapy in the Treatment of Neurofibromatosis 1 Related Internal Plexiform Neurofibromas Completed NCT01412892 Phase 2 RAD001: Everolimus
5 A Phase II Study of the mTOR Inhibitor Sirolimus in Neurofibromatosis Type 1 Related Plexiform Neurofibromas Completed NCT00634270 Phase 2 Sirolimus
6 Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform Neurofibromas Completed NCT00030264 Phase 2 Methotrexate;Vinblastine
7 Phase II Study of Gleevec/Imatinib Mesylate (STI-571, NCS 716051) in Neurofibromatosis (NF1) Patients With Plexiform Neurofibromas Completed NCT01673009 Phase 2 Gleevec
8 Pirfenidone in Children and Young Adults With Neurofibromatosis Type I and Progressive Plexiform Neurofibromas Completed NCT00076102 Phase 2 Pirfenidone
9 Pilot Study of Gleevec/Imatinib Mesylate (STI-571, NSC 716051) in Neurofibromatosis (NF1) Patient With Plexiform Neurofibromas Completed NCT01140360 Phase 1, Phase 2 Gleevec
10 R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas Completed NCT00021541 Phase 2 tipifarnib
11 Clinical Trial of Pirfenidone in Adult Patients With Neurofibromatosis 1 Completed NCT00754780 Phase 2 Pirfenidone
12 Study of Imatinib Mesylate in Neurofibromatosis Type I Patients Aged 2 to 21 With Plexiform Neurofibromas Recruiting NCT02177825 Phase 2 Imatinib Mesylate
13 Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas Recruiting NCT03231306 Phase 2 Binimetinib
14 Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibromas That Cannot Be Removed by Surgery Recruiting NCT02407405 Phase 2 Selumetinib
15 AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors Recruiting NCT01362803 Phase 1, Phase 2 AZD6244
16 Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in People With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST) Recruiting NCT03109301 Phase 2 Selumetinib (AZD6244 hyd sulfate)
17 Cabozantinib for Plexiform Neurofibromas (PN) in Subjects With NF1 (16 Years +) Active, not recruiting NCT02101736 Phase 2 Cabozantinib
18 MEK Inhibitor PD-0325901 Trial in Adolescents and Adults With NF1 Active, not recruiting NCT02096471 Phase 2 PD-0325901
19 Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours Not yet recruiting NCT03326388 Phase 1, Phase 2 Selumetinib
20 Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway. Not yet recruiting NCT03363217 Phase 1, Phase 2 Trametinib
21 Study of Sutent®/Sunitinib (SU11248) in Subjects With NF-1 Plexiform Neurofibromas Suspended NCT01402817 Phase 2 Sutent®/Sunitinib
22 PLX3397 in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) Suspended NCT02390752 Phase 1, Phase 2 PLX3397
23 Efficacy and Safety of RAD001 in Treating Plexiform Neurofibromas (PN) Associated With Neurofibromatosis (NF1) Terminated NCT01365468 Phase 2 Everolimus (RAD001)
24 AZD2171 in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibroma and/or Neurofibroma Near the Spine Terminated NCT00326872 Phase 2 Cediranib Maleate
25 Sorafenib to Treat Children and Young Adults With Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas Completed NCT00727233 Phase 1 Nexavar (BAY 43-9006) (Sorafenib);Toxicity, Pharmacokinetics;Pharmacodynamics;Radiographic Evaluation;QOL assessment, Neuropsychological;Bony Toxicity
26 Pirfenidone in Treating Young Patients With Neurofibromatosis Type 1 and Plexiform Neurofibromas Completed NCT00053937 Phase 1 pirfenidone
27 PEG-Interferon Alfa-2b in Treating Young Patients With Plexiform Neurofibroma Completed NCT00253474 Phase 1
28 Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1 Recruiting NCT02211768 Phase 1
29 Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations Recruiting NCT02124772 Phase 1 Trametinib;Dabrafenib
30 Phase I Clinical Study of the Safety of Photodynamic Therapy (PDT) Using LS11 in Children With Plexiform Neurofibromas Terminated NCT00716469 Phase 1 LS11
31 Whole Body Magnetic Resonance Imaging With Diffusion Weighted Imaging : Potential Role in Neurofibromatosis Unknown status NCT01777451
32 Study of Plexiform Neurofibromas in Neurofibromatosis Type 1 Completed NCT00006435
33 Study of Tasigna®/Nilotinib (AMN107) in Neurofibromatosis (NF1) Patients With Plexiform Neurofibromas Completed NCT01275586 Early Phase 1 Tasigna
34 Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development Completed NCT00340522
35 Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (PNs) Recruiting NCT02544022
36 Natural History Study of Patients With Neurofibromatosis Type I Recruiting NCT00924196
37 Targeting the Mechanisms Underlying Cutaneous Neurofibroma Formation in NF1: A Clinical Translational Approach. Recruiting NCT02777775
38 Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors Recruiting NCT03141021
39 PET/MRI in CNS and Extra-CNS Tumors of Patients With Neurofibromatosis-1 (NF1) Active, not recruiting NCT01800032
40 An Intermediate Access Protocol for Selumetinib for Treatment of Neurofibromatosis Type 1 Available NCT03259633 Selumetinib
41 Fludeoxyglucose F 18 Positron Emission Tomography and Magnetic Resonance Perfusion Imaging in Patients With Neurofibromatosis 1 and Plexiform Neurofibroma Terminated NCT00060008

Search NIH Clinical Center for Plexiform Neurofibroma

Cochrane evidence based reviews: neurofibroma, plexiform

Genetic Tests for Plexiform Neurofibroma

Genetic tests related to Plexiform Neurofibroma:

# Genetic test Affiliating Genes
1 Plexiform Neurofibroma 28

Anatomical Context for Plexiform Neurofibroma

MalaCards organs/tissues related to Plexiform Neurofibroma:

38
Salivary Gland, Bone, Tongue, Skin, Liver, Dorsal Root Ganglion, Trigeminal Ganglion

Publications for Plexiform Neurofibroma

Articles related to Plexiform Neurofibroma:

(show top 50) (show all 315)
# Title Authors Year
1
Intrahepatic plexiform neurofibroma with neurofibromatosis type 1. ( 29356283 )
2018
2
A brief report of plexiform neurofibroma. ( 29449010 )
2018
3
Plexiform Neurofibroma in the Axilla with Intraosseous Neurofibroma in the Humerus in Neurofibromatosis 5. ( 29441226 )
2018
4
Development of 3D culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening. ( 29055717 )
2018
5
Plexiform neurofibroma causing an ossifying subperiosteal haematoma: a rare case in the tibia of an 11-year-old girl. ( 28623408 )
2017
6
Plexiform Neurofibroma of Clitoris. ( 29142769 )
2017
7
Solitary Plexiform Neurofibroma of the Hepatic Artery. ( 28948502 )
2017
8
Monitoring of plexiform neurofibroma in children and adolescents with neurofibromatosis type 1 by [(18) F]FDG-PET imaging. Is it of value in asymptomatic patients? ( 28771999 )
2017
9
Giant congenital Becker's nevus overlying a plexiform neurofibroma: Merely a coincidence or more than it? ( 29210362 )
2017
10
An unexpected manifestation of extensive plexiform neurofibroma. ( 28681789 )
2017
11
Plexiform neurofibroma as a cause of carpal tunnel syndrome in a radial deficiency patient. ( 28554231 )
2017
12
Multiple Plexiform Neurofibroma of the Hand Misdiagnosed as Ganglion Cyst. ( 28442864 )
2017
13
Giant scalp plexiform neurofibroma associated with NF-1. ( 28928977 )
2017
14
Plexiform Neurofibroma Overlying Giant CafAc-au-lait Macule. ( 28405569 )
2017
15
BCRP expression in schwannoma, plexiform neurofibroma and MPNST. ( 29179472 )
2017
16
Plexiform Neurofibroma Involving the Lacrimal Gland. ( 28203199 )
2017
17
Rare triad of periampullary carcinoid, duodenal gastrointestinal stromal tumor and plexiform neurofibroma at hepatic hilum in neurofibromatosis type 1: a case report. ( 28851321 )
2017
18
The primacy of NF1 loss as the driver of tumorigenesis in neurofibromatosis type 1-associated plexiform neurofibromas. ( 28068329 )
2017
19
An Exceptional Case of Intraparotid Plexiform Neurofibroma Originating from Autonomic Fibers of the Auriculotemporal Nerve. ( 28634493 )
2017
20
Successful treatment by negative-pressure wound therapy for ulcer located on diffuse plexiform neurofibroma. ( 28734012 )
2017
21
Arteriovenous Malformation Underlying a Plexiform Neurofibroma: An Unusual Presentation. ( 28405554 )
2017
22
Plexiform neurofibroma. ( 27824540 )
2016
23
Isolated plexiform neurofibroma mimicking a vascular lesion. ( 27192529 )
2016
24
Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas. ( 28029918 )
2016
25
Sphenoid wing dysplasia and plexiform neurofibroma in neurofibromatosis type 1. ( 27061833 )
2016
26
Improvement of hyperpigmentation within a plexiform neurofibroma after treatment with Q-switched neodymium:yttrium-aluminium-garnet laser. ( 26880255 )
2016
27
Genetic basis of a solitary familial plexiform neurofibroma without verified associated neurofibromatosis. ( 27119482 )
2016
28
Solitary Non Syndromic Oral Plexiform Neurofibroma: a Case Report and Review of Literature. ( 27840843 )
2016
29
Plexiform Neurofibroma: A Case Report. ( 26871793 )
2016
30
A case of portal hypertension by presumed as plexiform neurofibroma at the hepatic hilum. ( 27209645 )
2016
31
Congenital extra calvarial plexiform neurofibroma in occipito-cervical region with Occipital bone defect with neurofibromatosis type 1 and segmental neurofibromatosis: Case report and review of literature. ( 28217149 )
2016
32
Multifactorial pathological hip subluxation in neurofibromatosis type-1 (NF1) due to intra-articular plexiform neurofibroma, lumbar radiculopathy and neurofibromatous polyneuropathy. ( 27932436 )
2016
33
Dual mTORC1/2 inhibition induces anti-proliferative effect in NF1-associated plexiform neurofibroma and malignant peripheral nerve sheath tumor cells. ( 26840085 )
2016
34
The Role of [(18)F]FDG-PET/CT in Predicting Malignant Transformation of Plexiform Neurofibromas in Neurofibromatosis-1. ( 28058117 )
2016
35
Multivacuolated mucin-filled cells: a unique cell characteristic of plexiform neurofibroma. A report of 11 cases. ( 27816720 )
2016
36
Magnetic resonance neurographic confirmation of extensive Plexiform neurofibroma in neurofibromatosis-1 presenting as ambiguous genitalia. ( 27857458 )
2016
37
Unusual location of a plexiform neurofibroma in the fallopian tube: A case report. ( 27641440 )
2016
38
Misdiagnosis of plexiform neurofibroma as venous malformation in pediatric patients. ( 26868134 )
2016
39
Initial Exploration on Temporal Branch of Facial Nerve Function Preservation in Plexiform Neurofibroma Resection. ( 27526236 )
2016
40
Hybrid resection of a giant thigh plexiform neurofibroma. ( 25603483 )
2015
41
Management of an expansile orbital mass: Plexiform neurofibroma decompression by orbitozygomatic approach. ( 25960281 )
2015
42
Partially Plexiform Neurofibroma of the Labia Minora and Clitoral Hood-A Prognostic Dilemma. ( 25658713 )
2015
43
Infant With a Unilateral Parotid Mass, Recurrent Otitis Media, and Macrocephaly. Plexiform neurofibroma. ( 26237456 )
2015
44
SRU Cases of the Day: Plexiform Neurofibroma. ( 26561219 )
2015
45
Preclinical assessment of the anticancer drug response of plexiform neurofibroma tissue using primary cultures. ( 25851896 )
2015
46
Giant cell tumor of the tendon sheath mimicking a plexiform neurofibroma. ( 26009718 )
2015
47
Massive Plexiform Neurofibroma of the Neck and Larynx. ( 26491483 )
2015
48
Ipsilateral Sphenoid Wing Dysplasia, Orbital Plexiform Neurofibroma and Fronto-Parietal Dermal Cylindroma in a Patient with Segmental Neurofibromatosis. ( 26637901 )
2015
49
Oral manifestations of neurofibromatosis type 1 in children with facial plexiform neurofibroma: report of three cases. ( 25823487 )
2015
50
Isolated plexiform neurofibroma of arm with unusual presentation - a rare case report. ( 25738048 )
2015

Variations for Plexiform Neurofibroma

Copy number variations for Plexiform Neurofibroma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 109397 17 25800000 31800000 Deletion NF1 Plexiform neurofibroma
2 109445 17 26082 26121 Microdeletion SUZ12 Plexiform neurofibroma
3 109456 17 26183 26246 Microdeletion ATAD5 Plexiform neurofibroma
4 109470 17 26273 26310 Microdeletion CENTA2 Plexiform neurofibroma
5 109475 17 26322 26351 Microdeletion RNF135 Plexiform neurofibroma
6 109535 17 26645 26648 Microdeletion OMG Plexiform neurofibroma
7 109543 17 26668 26672 Microdeletion EVI2A Plexiform neurofibroma
8 109598 17 27203 27210 Microdeletion C17orf79 Plexiform neurofibroma

Expression for Plexiform Neurofibroma

Search GEO for disease gene expression data for Plexiform Neurofibroma.

Pathways for Plexiform Neurofibroma

Pathways related to Plexiform Neurofibroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.36 BUB1B NEK2

GO Terms for Plexiform Neurofibroma

Cellular components related to Plexiform Neurofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.26 ANK3 BUB1B NEK2 NF2
2 nucleolus GO:0005730 8.92 KDM2B NEK2 NF1 NF2

Biological processes related to Plexiform Neurofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of MAPK cascade GO:0043408 9.26 NF1 SPRED1
2 negative regulation of cell-matrix adhesion GO:0001953 9.16 NF1 NF2
3 negative regulation of protein kinase activity GO:0006469 9.13 NF1 NF2 SPRED1
4 negative regulation of MAPK cascade GO:0043409 8.8 NF1 NF2 SPRED1

Molecular functions related to Plexiform Neurofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeletal protein binding GO:0008092 8.62 ANK3 NF2

Sources for Plexiform Neurofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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