MCID: PLX002
MIFTS: 50

Plexiform Neurofibroma malady

Neuronal diseases, Cancer diseases categories

Summaries for Plexiform Neurofibroma

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66Wikipedia, 34MalaCards
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Wikipedia:66 A solitary neurofibroma (also known as a \"Solitary nerve sheath tumor,\" and \"Sporadic neurofibroma\")... more...

MalaCards: Plexiform Neurofibroma, also known as neurofibroma plexiform, is related to neurofibroma and neurofibromatosis. An important gene associated with Plexiform Neurofibroma is GLI1 (GLI family zinc finger 1), and among its related pathways are Nuclear signaling by ERBB4 and Cell cycle Role of APC in cell cycle regulation. The compounds fluoride and nh4cl have been mentioned in the context of this disorder. Affiliated tissues include skin, salivary gland and bone, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Plexiform Neurofibroma

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

plexiform neurofibroma 9 63
neurofibroma plexiform 46


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Disease Ontology9 DOID:5151
MeSH36 D018318
SNOMED-CT59 41252002, 403818001
NCIt41 C3797

Related Diseases for Plexiform Neurofibroma

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18GeneCards, 19GeneDecks
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Diseases related to Plexiform Neurofibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibroma32.2NF2, S100B, NF1
2neurofibromatosis31.7NF1, NF2
3malignant peripheral nerve sheath tumor31.1NF1
4neuroma30.4ANK3
5neurofibrosarcoma30.4NF2, NF1
6meningioma30.3GAPDH, NF1, NF2, S100B
7adenocarcinoma30.2GLI1, NF2, GHR, GAPDH
8melanoma30.2S100B, GHR, NF1, GLI1, GAPDH, NF2
9cervicitis10.4
10hepatitis10.3
11laryngitis10.3
12meningocele10.2
13exophthalmos10.2
14muscular atrophy10.2
15obstructive jaundice10.2
16cellular schwannoma10.2
17carpal tunnel syndrome10.2
18amblyopia10.2
19angiosarcoma10.2
20hemangiopericytoma10.2
21intestinal obstruction10.2
22leiomyoma10.2
23lipoma10.2
24mediastinitis10.2
25myasthenia gravis10.2
26myopia10.2
27optic nerve glioma10.2
28pancreatitis10.2
29refractive error10.2
30giant congenital nevus10.2
31gigantism10.2
32macrodactyly of the foot10.2
33meningoencephalocele10.2
34sacrococcygeal teratoma10.2
35dysphagia10.2
36teratoma10.2
37hemifacial hypertrophy10.2
38perineurioma10.1S100B
39nervous system cancer10.1NF1, NF2
40neurilemmoma10.1NF1, NF2
41acoustic neuroma10.1NF1, NF2
42fibrous meningioma10.1S100B, NF2
43anaplastic ependymoma10.1NF2, S100B
44multiple endocrine neoplasia10.1NF1, NF2
45pilocytic astrocytoma10.1S100B, NF1
46skin benign neoplasm10.1GLI1, NF1
47noonan syndrome10.1GHR, NF1
48synovial sarcoma10.1NF1, S100B
49ependymoma10.1NF2, S100B, NF1
50gastrointestinal stromal tumor10.1NF1, NF2, S100B

Graphical network of the top 20 diseases related to Plexiform Neurofibroma:



Diseases related to plexiform neurofibroma

Symptoms for Plexiform Neurofibroma

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Drugs & Therapeutics for Plexiform Neurofibroma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Plexiform Neurofibroma

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Anatomical Context for Plexiform Neurofibroma

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34MalaCards
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MalaCards organs/tissues related to Plexiform Neurofibroma:

34
Skin, Salivary gland, Bone, Tongue, Liver, Dorsal root ganglion, Cervix, Colon, Testes, Eye, Spinal cord, Trigeminal ganglion

Animal Models for Plexiform Neurofibroma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Plexiform Neurofibroma:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.8B2M, GHR, NF2, NF1, GLI1
2MP:00020068.8B2M, BUB1B, NF2, NF1, GLI1
3MP:00053808.5BUB1B, GHR, NF2, NF1, GLI1
4MP:00053898.4GLI1, NF2, GHR, BUB1B, B2M
5MP:00053708.4B2M, GHR, NF2, NF1, GAPDH
6MP:00053678.2ANK3, GHR, NF2, NF1, GLI1, GAPDH
7MP:00036318.1B2M, ANK3, GHR, NF2, NF1, GLI1
8MP:00053868.0BUB1B, ANK3, GHR, S100B, NF2, NF1
9MP:00107717.8NF1, B2M, BUB1B, PBK, GHR, S100B
10MP:00053877.8B2M, BUB1B, PBK, GHR, NF2, NF1
11MP:00053787.4B2M, BUB1B, GHR, NF2, NF1, GLI1
12MP:00107687.1B2M, BUB1B, ANK3, GHR, NF2, NF1

Publications for Plexiform Neurofibroma

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53PubMed
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Articles related to Plexiform Neurofibroma:

(show top 50)    (show all 245)
idTitleAuthorsYear
1
Re: 'Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: An uncommon cause of severe urological disease in an infant' J Pediatr Urol 2013 Feb 4 [Epub ahead of print]. (23973761)
2013
2
Puberty and Plexiform Neurofibroma Tumor Growth in Patients with Neurofibromatosis Type I. (24321536)
2013
3
Synchronous plexiform neurofibroma in the arytenoids and neurofibroma in the parapharynx in a patient with non-neurofibromatosis: a case report. (23305487)
2013
4
Plexiform neurofibroma in the submandibular gland along with small diffuse neurofibroma in the floor of the mouth but without neurofibromatosis-1: a rare case report. (23653673)
2013
5
Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: an uncommon cause of severe urological disease in an infant. (23380157)
2013
6
Laryngeal plexiform neurofibroma in a child. (23780601)
2013
7
Growth dynamics of plexiform neurofibromas: a retrospective cohort study of 201 patients with neurofibromatosis 1. (23035791)
2012
8
Role of non-coding RNA ANRIL in the genesis of plexiform neurofibromas in neurofibromatosis type 1]. (22578354)
2012
9
Biallelic inactivation of NF1 in a sporadic plexiform neurofibroma. (22585738)
2012
10
Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial. (23099009)
2012
11
False-negative fluorine-18 fluorodeoxyglucose positron emission tomography of a malignant peripheral nerve sheath tumor arising from a plexiform neurofibroma in the setting of neurofibromatosis type 1. (21838076)
2011
12
Plexiform neurofibroma of the submandibular salivary gland: a rare tumour. (22654338)
2011
13
Intraoral plexiform neurofibroma involving the maxilla - pathognomonic of neurofibromatosis type I. (21977094)
2011
14
Experiences of families with a child, adolescent, or young adult with neurofibromatosis type 1 and plexiform neurofibroma evaluated for clinical trials participation at the National Cancer Institute. (20951236)
2011
15
Solitary oral plexiform neurofibroma: review of literature and report of a case. (21571578)
2011
16
Solitary plexiform neurofibroma, a pitfall in diagnosis of lipoma. (22778282)
2010
17
Giant plexiform neurofibroma in neurofibromatosis type 1. (20212235)
2010
18
Plexiform neurofibroma: a rare tumor of submandibular salivary gland. (22091342)
2010
19
Diffuse plexiform neurofibroma. (23133302)
2010
20
A case of isolated plexiform neurofibroma in a patient with myasthenia gravis. (20548857)
2009
21
Germline and somatic NF1 gene mutations in plexiform neurofibromas. (18484666)
2008
22
Cerclage technique for repairing large circular defects of the trunk: two-staged excision of a plexiform neurofibroma. (18384614)
2008
23
Unusual localization of a plexiform neurofibroma in a child with neurofibromatosis 1. (18954424)
2008
24
Plexiform neurofibroma of the finger. (18722169)
2008
25
Plexiform neurofibroma of the cauda equina: a case report and review of the literature. (18203792)
2008
26
Mesenteric plexiform neurofibroma in an 11-year-old boy with von Recklinghausen disease. (17560189)
2007
27
Pathology quiz case 1. Plexiform neurofibroma. (17372092)
2007
28
Hemimacroglossia caused by isolated plexiform neurofibroma: a case report. (16481830)
2006
29
Oral plexiform neurofibroma not associated with neurofibromatosis type I: case report. (17023749)
2006
30
Expression of CyclinD1, p27kp-1, and bcl-2 in plexiform neurofibroma with and without malignant transformation in neurofibromatosis type 1. (17718269)
2006
31
Plexiform neurofibroma mimicking a pancreatic cystic tumour. (16227365)
2005
32
Plexiform neurofibroma of the oesophagus: a mimicker of malignancy. (16352584)
2005
33
Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain. (15519868)
2004
34
Isolated plexiform neurofibroma: treatment with three-dimensional conformal radiotherapy. (15235336)
2004
35
Plexiform neurofibroma of the cheek mucosa. A case report. (15122129)
2004
36
Plexiform neurofibroma during and after pregnancy. (12410373)
2002
37
Plexiform neurofibroma of the penis in a child. (11018635)
2000
38
Enlarged penis due to a plexiform neurofibroma. (10524930)
1999
39
Quantitative analysis of NF1 and OMGP gene transcripts in sporadic gliomas, sporadic meningiomas and neurofibromatosis type 1-associated plexiform neurofibromas. (10378372)
1999
40
Intrahepatic plexiform neurofibroma in neurofibromatosis 1. (9732509)
1998
41
Prognostic signs in the surgical management of plexiform neurofibroma: the Children's Hospital of Philadelphia experience, 1974-1994. (9403645)
1997
42
Pelvic plexiform neurofibroma--an obstetric dilemma. (7904957)
1993
43
Large vascular plexiform neurofibroma of scalp: excision and coverage with free tissue transfer. (2301889)
1990
44
Pulsating orbital plexiform neurofibroma and optic nerve glioma. (2791937)
1989
45
Plexiform neurofibroma in children. (3743485)
1986
46
Plexiform (multinodular) schwannoma. A tumor simulating the plexiform neurofibroma. (6638259)
1983
47
Ultrasonography of a plexiform neurofibroma of the popliteal fossa. (6820385)
1982
48
Angiosarcoma arising in a plexiform neurofibroma: a case report. (7190462)
1980
49
Plexiform neurofibroma infiltrating the facial nerve. (420602)
1979
50
Plexiform neurofibroma of the lumbar region. Case report. (5766619)
1969

Variations for Plexiform Neurofibroma

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Expression for genes affiliated with Plexiform Neurofibroma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plexiform Neurofibroma

Search GEO for disease gene expression data for Plexiform Neurofibroma.

Pathways for genes affiliated with Plexiform Neurofibroma

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51PathCards, 56Reactome, 61Thomson Reuters
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Pathways related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7S100B, GHR
29.3NEK2, BUB1B

Compounds for genes affiliated with Plexiform Neurofibroma

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46Novoseek, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 12DrugBank
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Compounds related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1fluoride469.8B2M, NF1
2nh4cl469.4B2M, GAPDH
3deoxyribonucleic acid469.4GAPDH, NF2
4actb469.3GAPDH, GLI1, B2M
5progesterone46 30 62 25 1213.3GHR, S100B, NF2, NF1
6succinate469.3B2M, NF1, GAPDH
7hypoxanthine46 25 1211.2GAPDH, B2M
8sodium nitroprusside469.2GAPDH, S100B, B2M
9mannitol46 1210.2GAPDH, S100B, B2M
10rapamycin469.2GAPDH, NF1, NF2
11citric acid46 30 25 1212.1GAPDH, B2M
12steroid469.1NF1, S100B, GHR, B2M
13formaldehyde46 2510.1GAPDH, S100B, B2M
14paraffin469.0B2M, GHR, S100B, NF2, NF1
15vitamin a46 25 1210.8GAPDH, NF1, GHR, B2M
16dopamine46 30 25 1211.8GHR, S100B, NF1, GAPDH
17glutamine468.8B2M, GHR, S100B, GAPDH
18creatinine468.7GAPDH, S100B, GHR, B2M
19aspartate468.7B2M, GHR, S100B, GAPDH
20testosterone46 62 25 1211.6B2M, GHR, S100B, GAPDH
21alanine468.5GAPDH, NF1, S100B, GHR, B2M
22estrogen468.5B2M, GHR, S100B, NF1, GAPDH
23glucose468.5B2M, GHR, S100B, GLI1, GAPDH
24retinoic acid46 259.5B2M, GHR, S100B, NF1, GAPDH
25atp46 309.3GHR, S100B, NF1, GAPDH
26cysteine468.2B2M, GHR, S100B, NF2, NF1, GAPDH
27serine467.3GAPDH, B2M, NEK2, ANK3, GHR, S100B

GO Terms for genes affiliated with Plexiform Neurofibroma

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17Gene Ontology
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Cellular components related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic component of membraneGO:0198989.6NF2, GHR
2kinetochoreGO:0007769.3BUB1B, NEK2
3perinuclear region of cytoplasmGO:0484718.4GAPDH, NF2, S100B, BUB1B
4nucleusGO:0056347.2GAPDH, GLI1, NEK2, NF1, NF2, S100B
5cytoplasmGO:0057377.0NF1, GAPDH, NF2, S100B, NEK2, BUB1B

Biological processes related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:00195310.0NF1, NF2
2negative regulation of MAPK cascadeGO:0434099.9NF2, NF1
3negative regulation of protein kinase activityGO:0064699.9NF1, NF2
4osteoblast differentiationGO:0016499.6GLI1, NF1
5mitosisGO:0070678.7BUB1B, NEK2, PBK

Molecular functions related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein serine/threonine kinase activityGO:0046748.8BUB1B, NEK2, PBK
2protein bindingGO:0055155.3B2M, BUB1B, NEK2, ANK3, PBK, GHR

Products for genes affiliated with Plexiform Neurofibroma

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Sources for Plexiform Neurofibroma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet