MCID: PLX002
MIFTS: 50

Plexiform Neurofibroma malady

Cancer diseases, Neuronal diseases categories
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Summaries for Plexiform Neurofibroma

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Wikipedia:65 A solitary neurofibroma (also known as a \"Solitary nerve sheath tumor,\" and \"Sporadic neurofibroma\")... more...

MalaCards based summary: Plexiform Neurofibroma, also known as neurofibroma plexiform, is related to neurofibroma and neurofibromatosis. An important gene associated with Plexiform Neurofibroma is GLI1 (GLI family zinc finger 1), and among its related pathways are Nuclear signaling by ERBB4 and Cell cycle Role of APC in cell cycle regulation. The compounds fluoride and nh4cl have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and salivary gland, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Plexiform Neurofibroma

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Sources:
8Disease Ontology, 62UMLS, 44Novoseek, 39NCIt, 34MeSH, 57SNOMED-CT
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Plexiform Neurofibroma, Aliases & Descriptions:

Name: Plexiform Neurofibroma 8 62
 
Neurofibroma Plexiform 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:5151
NCIt39 C3797
SNOMED-CT57 403818001, 41252002
MeSH34 D018318

Related Diseases for Plexiform Neurofibroma

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Diseases related to Plexiform Neurofibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibroma32.5NF1, NF2, S100B
2neurofibromatosis32.1NF2, NF1
3malignant peripheral nerve sheath tumor31.7NF1
4neuroma31.0ANK3
5neurofibrosarcoma30.9NF2, NF1
6meningioma30.3S100B, NF2, NF1, GAPDH
7adenocarcinoma30.0GHR, NF2, GLI1, GAPDH
8melanoma29.8GHR, S100B, NF2, NF1, GLI1, GAPDH
9perineurioma10.5S100B
10cervicitis10.4
11nervous system cancer10.4NF2, NF1
12neurilemmoma10.4NF1, NF2
13acoustic neuroma10.4NF2, NF1
14fibrous meningioma10.4S100B, NF2
15anaplastic ependymoma10.4NF2, S100B
16hepatitis10.3
17ganglioneuroma10.3
18choroiditis10.3
19laryngitis10.3
20multiple endocrine neoplasia10.3NF1, NF2
21pilocytic astrocytoma10.3S100B, NF1
22skin benign neoplasm10.3NF1, GLI1
23noonan syndrome10.3GHR, NF1
24synovial sarcoma10.2S100B, NF1
25ependymoma10.2S100B, NF2, NF1
26gastrointestinal stromal tumor10.2NF1, NF2, S100B
27paraganglioma10.2NF1, S100B
28brain cancer10.2GLI1, NF1, NF2
29secondary hyperparathyroidism of renal origin10.2B2M, GHR
30myasthenia gravis10.2
31sacrococcygeal teratoma10.2
32meningocele10.2
33muscular atrophy10.2
34obstructive jaundice10.2
35exophthalmos10.2
36carpal tunnel syndrome10.2
37oculocutaneous albinism10.2
38cellular schwannoma10.2
39buphthalmos10.2
40amblyopia10.2
41angiosarcoma10.2
42hemangiopericytoma10.2
43intestinal obstruction10.2
44leiomyoma10.2
45lipoma10.2
46mediastinitis10.2
47myopia10.2
48optic nerve glioma10.2
49pancreatitis10.2
50refractive error10.2

Graphical network of the top 20 diseases related to Plexiform Neurofibroma:



Diseases related to plexiform neurofibroma

Symptoms for Plexiform Neurofibroma

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Drugs & Therapeutics for Plexiform Neurofibroma

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Drug clinical trials:

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Search NIH Clinical Center for Plexiform Neurofibroma

Genetic Tests for Plexiform Neurofibroma

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Anatomical Context for Plexiform Neurofibroma

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MalaCards organs/tissues related to Plexiform Neurofibroma:

32
Skin, Bone, Salivary gland, Tongue, Liver, Eye, Spinal cord, Colon, Uterus, Testes, Cervix, Dorsal root ganglion, Trigeminal ganglion

Animal Models for Plexiform Neurofibroma or affiliated genes

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MGI Mouse Phenotypes related to Plexiform Neurofibroma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.8B2M, GHR, NF2, NF1, GLI1
2MP:00020068.8B2M, BUB1B, NF2, NF1, GLI1
3MP:00053808.5BUB1B, GHR, NF2, NF1, GLI1
4MP:00053898.4GLI1, NF2, GHR, BUB1B, B2M
5MP:00053708.4B2M, GHR, NF2, NF1, GAPDH
6MP:00053678.2ANK3, GHR, NF2, NF1, GLI1, GAPDH
7MP:00036318.1B2M, ANK3, GHR, NF2, NF1, GLI1
8MP:00053868.0BUB1B, ANK3, GHR, S100B, NF2, NF1
9MP:00107717.8NF1, B2M, BUB1B, PBK, GHR, S100B
10MP:00053877.8B2M, BUB1B, PBK, GHR, NF2, NF1
11MP:00053787.4B2M, BUB1B, GHR, NF2, NF1, GLI1
12MP:00107687.1B2M, BUB1B, ANK3, GHR, NF2, NF1

Publications for Plexiform Neurofibroma

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Articles related to Plexiform Neurofibroma:

(show top 50)    (show all 259)
idTitleAuthorsYear
1
Solitary plexiform neurofibroma of the stomach: a case report. (24803834)
2014
2
Choroidal Ganglioneuroma and Orbital Plexiform Neurofibroma Presenting as Buphthalmos in an Infant With Neurofibromatosis Type 1. (25186217)
2014
3
Co-occurrence of choroidal pigmented ganglioneuroma and plexiform neurofibroma in a patient with neurofibromatosis 1. (24656164)
2014
4
Re: 'Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: An uncommon cause of severe urological disease in an infant' J Pediatr Urol 2013 Feb 4 [Epub ahead of print]. (23973761)
2013
5
Puberty and Plexiform Neurofibroma Tumor Growth in Patients with Neurofibromatosis Type I. (24321536)
2013
6
Synchronous plexiform neurofibroma in the arytenoids and neurofibroma in the parapharynx in a patient with non-neurofibromatosis: a case report. (23305487)
2013
7
Plexiform neurofibroma in the submandibular gland along with small diffuse neurofibroma in the floor of the mouth but without neurofibromatosis-1: a rare case report. (23653673)
2013
8
Growth dynamics of plexiform neurofibromas: a retrospective cohort study of 201 patients with neurofibromatosis 1. (23035791)
2012
9
Role of non-coding RNA ANRIL in the genesis of plexiform neurofibromas in neurofibromatosis type 1]. (22578354)
2012
10
Biallelic inactivation of NF1 in a sporadic plexiform neurofibroma. (22585738)
2012
11
Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial. (23099009)
2012
12
False-negative fluorine-18 fluorodeoxyglucose positron emission tomography of a malignant peripheral nerve sheath tumor arising from a plexiform neurofibroma in the setting of neurofibromatosis type 1. (21838076)
2011
13
Plexiform neurofibroma of the submandibular salivary gland: a rare tumour. (22654338)
2011
14
Intraoral plexiform neurofibroma involving the maxilla - pathognomonic of neurofibromatosis type I. (21977094)
2011
15
Experiences of families with a child, adolescent, or young adult with neurofibromatosis type 1 and plexiform neurofibroma evaluated for clinical trials participation at the National Cancer Institute. (20951236)
2011
16
Solitary oral plexiform neurofibroma: review of literature and report of a case. (21571578)
2011
17
Solitary plexiform neurofibroma, a pitfall in diagnosis of lipoma. (22778282)
2010
18
Giant plexiform neurofibroma in neurofibromatosis type 1. (20212235)
2010
19
Plexiform neurofibroma: a rare tumor of submandibular salivary gland. (22091342)
2010
20
Diffuse plexiform neurofibroma. (23133302)
2010
21
A case of isolated plexiform neurofibroma in a patient with myasthenia gravis. (20548857)
2009
22
Germline and somatic NF1 gene mutations in plexiform neurofibromas. (18484666)
2008
23
Cerclage technique for repairing large circular defects of the trunk: two-staged excision of a plexiform neurofibroma. (18384614)
2008
24
Unusual localization of a plexiform neurofibroma in a child with neurofibromatosis 1. (18954424)
2008
25
Plexiform neurofibroma of the finger. (18722169)
2008
26
Plexiform neurofibroma of the cauda equina: a case report and review of the literature. (18203792)
2008
27
Mesenteric plexiform neurofibroma in an 11-year-old boy with von Recklinghausen disease. (17560189)
2007
28
Pathology quiz case 1. Plexiform neurofibroma. (17372092)
2007
29
Hemimacroglossia caused by isolated plexiform neurofibroma: a case report. (16481830)
2006
30
Oral plexiform neurofibroma not associated with neurofibromatosis type I: case report. (17023749)
2006
31
Expression of CyclinD1, p27kp-1, and bcl-2 in plexiform neurofibroma with and without malignant transformation in neurofibromatosis type 1. (17718269)
2006
32
Plexiform neurofibroma mimicking a pancreatic cystic tumour. (16227365)
2005
33
Plexiform neurofibroma of the oesophagus: a mimicker of malignancy. (16352584)
2005
34
Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain. (15519868)
2004
35
Isolated plexiform neurofibroma: treatment with three-dimensional conformal radiotherapy. (15235336)
2004
36
Plexiform neurofibroma during and after pregnancy. (12410373)
2002
37
Plexiform neurofibroma of the penis in a child. (11018635)
2000
38
Enlarged penis due to a plexiform neurofibroma. (10524930)
1999
39
Quantitative analysis of NF1 and OMGP gene transcripts in sporadic gliomas, sporadic meningiomas and neurofibromatosis type 1-associated plexiform neurofibromas. (10378372)
1999
40
Intrahepatic plexiform neurofibroma in neurofibromatosis 1. (9732509)
1998
41
Prognostic signs in the surgical management of plexiform neurofibroma: the Children's Hospital of Philadelphia experience, 1974-1994. (9403645)
1997
42
Pelvic plexiform neurofibroma--an obstetric dilemma. (7904957)
1993
43
Large vascular plexiform neurofibroma of scalp: excision and coverage with free tissue transfer. (2301889)
1990
44
Pulsating orbital plexiform neurofibroma and optic nerve glioma. (2791937)
1989
45
Plexiform neurofibroma in children. (3743485)
1986
46
Plexiform (multinodular) schwannoma. A tumor simulating the plexiform neurofibroma. (6638259)
1983
47
Ultrasonography of a plexiform neurofibroma of the popliteal fossa. (6820385)
1982
48
Angiosarcoma arising in a plexiform neurofibroma: a case report. (7190462)
1980
49
Plexiform neurofibroma infiltrating the facial nerve. (420602)
1979
50
Plexiform neurofibroma of the lumbar region. Case report. (5766619)
1969

Variations for Plexiform Neurofibroma

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Expression for genes affiliated with Plexiform Neurofibroma

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Expression patterns in normal tissues for genes affiliated with Plexiform Neurofibroma

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Pathways for genes affiliated with Plexiform Neurofibroma

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Pathways related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7S100B, GHR
29.3NEK2, BUB1B

Compounds for genes affiliated with Plexiform Neurofibroma

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Sources:
44Novoseek, 28IUPHAR, 61Tocris Bioscience, 24HMDB, 11DrugBank
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Compounds related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1fluoride449.8B2M, NF1
2nh4cl449.4B2M, GAPDH
3deoxyribonucleic acid449.4GAPDH, NF2
4actb449.3GAPDH, GLI1, B2M
5progesterone44 28 61 24 1113.3GHR, S100B, NF2, NF1
6succinate449.3B2M, NF1, GAPDH
7hypoxanthine44 24 1111.2GAPDH, B2M
8sodium nitroprusside449.2GAPDH, S100B, B2M
9mannitol44 1110.2GAPDH, S100B, B2M
10rapamycin449.2GAPDH, NF1, NF2
11citric acid44 28 24 1112.1GAPDH, B2M
12steroid449.1NF1, S100B, GHR, B2M
13formaldehyde44 2410.1GAPDH, S100B, B2M
14paraffin449.0B2M, GHR, S100B, NF2, NF1
15vitamin a44 24 1110.8GAPDH, NF1, GHR, B2M
16dopamine44 28 24 1111.8GHR, S100B, NF1, GAPDH
17glutamine448.8B2M, GHR, S100B, GAPDH
18creatinine448.7GAPDH, S100B, GHR, B2M
19aspartate448.7B2M, GHR, S100B, GAPDH
20testosterone44 61 24 1111.6B2M, GHR, S100B, GAPDH
21alanine448.5GAPDH, NF1, S100B, GHR, B2M
22estrogen448.5B2M, GHR, S100B, NF1, GAPDH
23glucose448.5B2M, GHR, S100B, GLI1, GAPDH
24retinoic acid44 249.5B2M, GHR, S100B, NF1, GAPDH
25atp44 289.3GHR, S100B, NF1, GAPDH
26cysteine448.2B2M, GHR, S100B, NF2, NF1, GAPDH
27serine447.3GAPDH, B2M, NEK2, ANK3, GHR, S100B

GO Terms for genes affiliated with Plexiform Neurofibroma

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Cellular components related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic component of membraneGO:0198989.6NF2, GHR
2kinetochoreGO:0007769.3NEK2, BUB1B
3perinuclear region of cytoplasmGO:0484718.4BUB1B, S100B, NF2, GAPDH
4nucleusGO:0056347.2NEK2, GHR, S100B, NF2, NF1, GLI1
5cytoplasmGO:0057377.0GAPDH, B2M, BUB1B, NEK2, S100B, NF2

Biological processes related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:00195310.0NF1, NF2
2negative regulation of MAPK cascadeGO:0434099.9NF1, NF2
3negative regulation of protein kinase activityGO:0064699.9NF1, NF2
4osteoblast differentiationGO:0016499.6GLI1, NF1
5mitosisGO:0070678.7BUB1B, NEK2, PBK

Molecular functions related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein serine/threonine kinase activityGO:0046748.8PBK, NEK2, BUB1B
2protein bindingGO:0055155.3GAPDH, B2M, BUB1B, NEK2, ANK3, PBK

Products for genes affiliated with Plexiform Neurofibroma

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Sources for Plexiform Neurofibroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet