MCID: PLX002
MIFTS: 50

Plexiform Neurofibroma malady

Neuronal diseases, Cancer diseases categories
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Summaries for Plexiform Neurofibroma

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65Wikipedia, 33MalaCards
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Wikipedia:65 A solitary neurofibroma (also known as a \"Solitary nerve sheath tumor,\" and \"Sporadic neurofibroma\")... more...

MalaCards: Plexiform Neurofibroma, also known as neurofibroma plexiform, is related to neurofibroma and neurofibromatosis. An important gene associated with Plexiform Neurofibroma is GLI1 (GLI family zinc finger 1), and among its related pathways are Nuclear signaling by ERBB4 and Cell cycle Role of APC in cell cycle regulation. The compounds fluoride and nh4cl have been mentioned in the context of this disorder. Affiliated tissues include skin, salivary gland and bone, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Plexiform Neurofibroma

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

plexiform neurofibroma 8 62
neurofibroma plexiform 45


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Disease Ontology8 DOID:5151
MeSH35 D018318
SNOMED-CT58 41252002, 403818001
NCIt40 C3797

Related Diseases for Plexiform Neurofibroma

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17GeneCards, 18GeneDecks
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Diseases related to Plexiform Neurofibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibroma32.2NF2, S100B, NF1
2neurofibromatosis31.7NF1, NF2
3malignant peripheral nerve sheath tumor31.1NF1
4neuroma30.4ANK3
5neurofibrosarcoma30.4NF2, NF1
6meningioma30.3GAPDH, NF1, NF2, S100B
7adenocarcinoma30.2GLI1, NF2, GHR, GAPDH
8melanoma30.2S100B, GHR, NF1, GLI1, GAPDH, NF2
9cervicitis10.4
10hepatitis10.3
11laryngitis10.3
12meningocele10.2
13exophthalmos10.2
14muscular atrophy10.2
15obstructive jaundice10.2
16cellular schwannoma10.2
17carpal tunnel syndrome10.2
18amblyopia10.2
19angiosarcoma10.2
20hemangiopericytoma10.2
21intestinal obstruction10.2
22leiomyoma10.2
23lipoma10.2
24mediastinitis10.2
25myasthenia gravis10.2
26myopia10.2
27optic nerve glioma10.2
28pancreatitis10.2
29refractive error10.2
30giant congenital nevus10.2
31gigantism10.2
32macrodactyly of the foot10.2
33meningoencephalocele10.2
34sacrococcygeal teratoma10.2
35dysphagia10.2
36teratoma10.2
37hemifacial hypertrophy10.2
38perineurioma10.1S100B
39nervous system cancer10.1NF1, NF2
40neurilemmoma10.1NF1, NF2
41acoustic neuroma10.1NF1, NF2
42fibrous meningioma10.1S100B, NF2
43anaplastic ependymoma10.1NF2, S100B
44multiple endocrine neoplasia10.1NF1, NF2
45pilocytic astrocytoma10.1S100B, NF1
46skin benign neoplasm10.1GLI1, NF1
47noonan syndrome10.1GHR, NF1
48synovial sarcoma10.1NF1, S100B
49ependymoma10.1NF2, S100B, NF1
50gastrointestinal stromal tumor10.1NF1, NF2, S100B

Graphical network of the top 20 diseases related to Plexiform Neurofibroma:



Diseases related to plexiform neurofibroma

Symptoms for Plexiform Neurofibroma

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Drugs & Therapeutics for Plexiform Neurofibroma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Plexiform Neurofibroma

Search NIH Clinical Center for Plexiform Neurofibroma

Genetic Tests for Plexiform Neurofibroma

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Anatomical Context for Plexiform Neurofibroma

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33MalaCards
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MalaCards organs/tissues related to Plexiform Neurofibroma:

33
Skin, Salivary gland, Bone, Tongue, Liver, Dorsal root ganglion, Cervix, Colon, Testes, Eye, Spinal cord, Trigeminal ganglion

Animal Models for Plexiform Neurofibroma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Plexiform Neurofibroma:

37 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.8B2M, GHR, NF2, NF1, GLI1
2MP:00020068.8B2M, BUB1B, NF2, NF1, GLI1
3MP:00053808.5BUB1B, GHR, NF2, NF1, GLI1
4MP:00053898.4GLI1, NF2, GHR, BUB1B, B2M
5MP:00053708.4B2M, GHR, NF2, NF1, GAPDH
6MP:00053678.2ANK3, GHR, NF2, NF1, GLI1, GAPDH
7MP:00036318.1B2M, ANK3, GHR, NF2, NF1, GLI1
8MP:00053868.0BUB1B, ANK3, GHR, S100B, NF2, NF1
9MP:00107717.8NF1, B2M, BUB1B, PBK, GHR, S100B
10MP:00053877.8B2M, BUB1B, PBK, GHR, NF2, NF1
11MP:00053787.4B2M, BUB1B, GHR, NF2, NF1, GLI1
12MP:00107687.1B2M, BUB1B, ANK3, GHR, NF2, NF1

Publications for Plexiform Neurofibroma

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52PubMed
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Articles related to Plexiform Neurofibroma:

(show top 50)    (show all 245)
idTitleAuthorsYear
1
Re: 'Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: An uncommon cause of severe urological disease in an infant' J Pediatr Urol 2013 Feb 4 [Epub ahead of print]. (23973761)
2013
2
Puberty and Plexiform Neurofibroma Tumor Growth in Patients with Neurofibromatosis Type I. (24321536)
2013
3
Synchronous plexiform neurofibroma in the arytenoids and neurofibroma in the parapharynx in a patient with non-neurofibromatosis: a case report. (23305487)
2013
4
Plexiform neurofibroma in the submandibular gland along with small diffuse neurofibroma in the floor of the mouth but without neurofibromatosis-1: a rare case report. (23653673)
2013
5
Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: an uncommon cause of severe urological disease in an infant. (23380157)
2013
6
Laryngeal plexiform neurofibroma in a child. (23780601)
2013
7
Growth dynamics of plexiform neurofibromas: a retrospective cohort study of 201 patients with neurofibromatosis 1. (23035791)
2012
8
Role of non-coding RNA ANRIL in the genesis of plexiform neurofibromas in neurofibromatosis type 1]. (22578354)
2012
9
Biallelic inactivation of NF1 in a sporadic plexiform neurofibroma. (22585738)
2012
10
Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial. (23099009)
2012
11
False-negative fluorine-18 fluorodeoxyglucose positron emission tomography of a malignant peripheral nerve sheath tumor arising from a plexiform neurofibroma in the setting of neurofibromatosis type 1. (21838076)
2011
12
Plexiform neurofibroma of the submandibular salivary gland: a rare tumour. (22654338)
2011
13
Intraoral plexiform neurofibroma involving the maxilla - pathognomonic of neurofibromatosis type I. (21977094)
2011
14
Experiences of families with a child, adolescent, or young adult with neurofibromatosis type 1 and plexiform neurofibroma evaluated for clinical trials participation at the National Cancer Institute. (20951236)
2011
15
Solitary oral plexiform neurofibroma: review of literature and report of a case. (21571578)
2011
16
Solitary plexiform neurofibroma, a pitfall in diagnosis of lipoma. (22778282)
2010
17
Giant plexiform neurofibroma in neurofibromatosis type 1. (20212235)
2010
18
Plexiform neurofibroma: a rare tumor of submandibular salivary gland. (22091342)
2010
19
Diffuse plexiform neurofibroma. (23133302)
2010
20
A case of isolated plexiform neurofibroma in a patient with myasthenia gravis. (20548857)
2009
21
Germline and somatic NF1 gene mutations in plexiform neurofibromas. (18484666)
2008
22
Cerclage technique for repairing large circular defects of the trunk: two-staged excision of a plexiform neurofibroma. (18384614)
2008
23
Unusual localization of a plexiform neurofibroma in a child with neurofibromatosis 1. (18954424)
2008
24
Plexiform neurofibroma of the finger. (18722169)
2008
25
Plexiform neurofibroma of the cauda equina: a case report and review of the literature. (18203792)
2008
26
Mesenteric plexiform neurofibroma in an 11-year-old boy with von Recklinghausen disease. (17560189)
2007
27
Pathology quiz case 1. Plexiform neurofibroma. (17372092)
2007
28
Hemimacroglossia caused by isolated plexiform neurofibroma: a case report. (16481830)
2006
29
Oral plexiform neurofibroma not associated with neurofibromatosis type I: case report. (17023749)
2006
30
Expression of CyclinD1, p27kp-1, and bcl-2 in plexiform neurofibroma with and without malignant transformation in neurofibromatosis type 1. (17718269)
2006
31
Plexiform neurofibroma mimicking a pancreatic cystic tumour. (16227365)
2005
32
Plexiform neurofibroma of the oesophagus: a mimicker of malignancy. (16352584)
2005
33
Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain. (15519868)
2004
34
Isolated plexiform neurofibroma: treatment with three-dimensional conformal radiotherapy. (15235336)
2004
35
Plexiform neurofibroma of the cheek mucosa. A case report. (15122129)
2004
36
Plexiform neurofibroma during and after pregnancy. (12410373)
2002
37
Plexiform neurofibroma of the penis in a child. (11018635)
2000
38
Enlarged penis due to a plexiform neurofibroma. (10524930)
1999
39
Quantitative analysis of NF1 and OMGP gene transcripts in sporadic gliomas, sporadic meningiomas and neurofibromatosis type 1-associated plexiform neurofibromas. (10378372)
1999
40
Intrahepatic plexiform neurofibroma in neurofibromatosis 1. (9732509)
1998
41
Prognostic signs in the surgical management of plexiform neurofibroma: the Children's Hospital of Philadelphia experience, 1974-1994. (9403645)
1997
42
Pelvic plexiform neurofibroma--an obstetric dilemma. (7904957)
1993
43
Large vascular plexiform neurofibroma of scalp: excision and coverage with free tissue transfer. (2301889)
1990
44
Pulsating orbital plexiform neurofibroma and optic nerve glioma. (2791937)
1989
45
Plexiform neurofibroma in children. (3743485)
1986
46
Plexiform (multinodular) schwannoma. A tumor simulating the plexiform neurofibroma. (6638259)
1983
47
Ultrasonography of a plexiform neurofibroma of the popliteal fossa. (6820385)
1982
48
Angiosarcoma arising in a plexiform neurofibroma: a case report. (7190462)
1980
49
Plexiform neurofibroma infiltrating the facial nerve. (420602)
1979
50
Plexiform neurofibroma of the lumbar region. Case report. (5766619)
1969

Variations for Plexiform Neurofibroma

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Expression for genes affiliated with Plexiform Neurofibroma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Plexiform Neurofibroma

Search GEO for disease gene expression data for Plexiform Neurofibroma.

Pathways for genes affiliated with Plexiform Neurofibroma

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50PathCards, 55Reactome, 60Thomson Reuters
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Pathways related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7S100B, GHR
29.3NEK2, BUB1B

Compounds for genes affiliated with Plexiform Neurofibroma

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45Novoseek, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 11DrugBank
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Compounds related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1fluoride459.8B2M, NF1
2nh4cl459.4B2M, GAPDH
3deoxyribonucleic acid459.4GAPDH, NF2
4actb459.3GAPDH, GLI1, B2M
5progesterone45 29 61 24 1113.3GHR, S100B, NF2, NF1
6succinate459.3B2M, NF1, GAPDH
7hypoxanthine45 24 1111.2GAPDH, B2M
8sodium nitroprusside459.2GAPDH, S100B, B2M
9mannitol45 1110.2GAPDH, S100B, B2M
10rapamycin459.2GAPDH, NF1, NF2
11citric acid45 29 24 1112.1GAPDH, B2M
12steroid459.1NF1, S100B, GHR, B2M
13formaldehyde45 2410.1GAPDH, S100B, B2M
14paraffin459.0B2M, GHR, S100B, NF2, NF1
15vitamin a45 24 1110.8GAPDH, NF1, GHR, B2M
16dopamine45 29 24 1111.8GHR, S100B, NF1, GAPDH
17glutamine458.8B2M, GHR, S100B, GAPDH
18creatinine458.7GAPDH, S100B, GHR, B2M
19aspartate458.7B2M, GHR, S100B, GAPDH
20testosterone45 61 24 1111.6B2M, GHR, S100B, GAPDH
21alanine458.5GAPDH, NF1, S100B, GHR, B2M
22estrogen458.5B2M, GHR, S100B, NF1, GAPDH
23glucose458.5B2M, GHR, S100B, GLI1, GAPDH
24retinoic acid45 249.5B2M, GHR, S100B, NF1, GAPDH
25atp45 299.3GHR, S100B, NF1, GAPDH
26cysteine458.2B2M, GHR, S100B, NF2, NF1, GAPDH
27serine457.3GAPDH, B2M, NEK2, ANK3, GHR, S100B

GO Terms for genes affiliated with Plexiform Neurofibroma

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16Gene Ontology
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Cellular components related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic component of membraneGO:0198989.6NF2, GHR
2kinetochoreGO:0007769.3BUB1B, NEK2
3perinuclear region of cytoplasmGO:0484718.4GAPDH, NF2, S100B, BUB1B
4nucleusGO:0056347.2GAPDH, GLI1, NEK2, NF1, NF2, S100B
5cytoplasmGO:0057377.0NF1, GAPDH, NF2, S100B, NEK2, BUB1B

Biological processes related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:00195310.0NF1, NF2
2negative regulation of MAPK cascadeGO:0434099.9NF2, NF1
3negative regulation of protein kinase activityGO:0064699.9NF1, NF2
4osteoblast differentiationGO:0016499.6GLI1, NF1
5mitosisGO:0070678.7BUB1B, NEK2, PBK

Molecular functions related to Plexiform Neurofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein serine/threonine kinase activityGO:0046748.8BUB1B, NEK2, PBK
2protein bindingGO:0055155.3B2M, BUB1B, NEK2, ANK3, PBK, GHR

Products for genes affiliated with Plexiform Neurofibroma

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Sources for Plexiform Neurofibroma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet