MCID: PLX001
MIFTS: 34

Plexiform Schwannoma

Categories: Cancer diseases

Aliases & Classifications for Plexiform Schwannoma

MalaCards integrated aliases for Plexiform Schwannoma:

Name: Plexiform Schwannoma 12 14 69
Plexiform Neurilemmoma 12
Plexiform Neurinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3206
NCIt 46 C6969
UMLS 69 C1370659

Summaries for Plexiform Schwannoma

MalaCards based summary : Plexiform Schwannoma, also known as plexiform neurilemmoma, is related to neurofibromatosis, type iv, of riccardi and neurilemmoma. An important gene associated with Plexiform Schwannoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Neuroscience and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include trachea, tongue and breast, and related phenotypes are behavior/neurological and cellular

Related Diseases for Plexiform Schwannoma

Diseases related to Plexiform Schwannoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 neurofibromatosis, type iv, of riccardi 30.6 KIT NF1 NF2
2 neurilemmoma 28.0 ENO2 GFAP KIT NF1 NF2 NGFR
3 neurofibromatosis, familial spinal 10.5 NF1 NF2
4 neurofibrosarcoma 10.5 NF1 NF2
5 meningothelial meningioma 10.4 ENO2 NF2
6 immature cataract 10.4 NF1 NF2
7 plexiform neurofibroma 10.4 NF1 NF2
8 amyloid tumor 10.4 NF1 NF2
9 neurilemmomatosis 10.4 NF1 NF2
10 duodenal somatostatinoma 10.4 ENO2 NF1
11 epithelioid malignant peripheral nerve sheath tumor 10.4 ENO2 NF1
12 epithelioid neurofibroma 10.4 CD34 DSP
13 melanotic neurilemmoma 10.4 CD34 NF2
14 psammomatous meningioma 10.4 CD34 NF2
15 cutaneous ganglioneuroma 10.3 ENO2 KIT
16 gastric leiomyosarcoma 10.3 ENO2 KIT
17 endometrial small cell carcinoma 10.3 ENO2 KIT
18 rete testis adenocarcinoma 10.3 ENO2 KIT
19 vulvar melanoma 10.3 KIT NF1
20 small cell neuroendocrine carcinoma 10.3 ENO2 KIT
21 neurofibromatosis, type i 10.3 KIT NF1
22 heart sarcoma 10.3 ENO2 KIT
23 epulis 10.3 ENO2 NGFR
24 rete testis neoplasm 10.3 ENO2 KIT
25 lymphangiosarcoma 10.3 CD34 DSP
26 gallbladder leiomyoma 10.3 CD34 KIT
27 lung leiomyosarcoma 10.3 CD34 KIT
28 liver leiomyoma 10.3 CD34 KIT
29 mixed cell type cancer 10.2 ENO2 KIT
30 extracutaneous mastocytoma 10.2 CD34 KIT
31 small intestine leiomyosarcoma 10.2 CD34 KIT
32 small intestinal sarcoma 10.2 CD34 KIT
33 gallbladder sarcoma 10.2 CD34 KIT
34 prostate leiomyosarcoma 10.2 CD34 KIT
35 malignant glandular tumor of peripheral nerve sheath 10.2 B3GAT1 NF1
36 pleomorphic lipoma 10.2 CD34 NF1
37 diffuse cutaneous mastocytosis 10.2 CD34 KIT
38 sarcomatoid squamous cell skin carcinoma 10.2 CD34 KIT
39 breast angiosarcoma 10.2 CD34 KIT
40 follicular dendritic cell sarcoma 10.2 DSP KIT
41 spindle cell liposarcoma 10.2 CD34 KIT
42 large cell neuroendocrine carcinoma 10.2 ENO2 KIT
43 kidney rhabdoid cancer 10.2 B3GAT1 ENO2
44 spinal canal and spinal cord meningioma 10.2 ENO2 NF1 NF2
45 spinal meningioma 10.2 ENO2 NF1 NF2
46 olfactory neuroblastoma 10.2 ENO2 NGFR
47 optic nerve neoplasm 10.2 ENO2 NF1 NF2
48 mesenchymal cell neoplasm 10.2 CD34 KIT
49 exophthalmos 10.2 CD34 NF1
50 intraneural perineurioma 10.2 CD34 NF1

Graphical network of the top 20 diseases related to Plexiform Schwannoma:



Diseases related to Plexiform Schwannoma

Symptoms & Phenotypes for Plexiform Schwannoma

MGI Mouse Phenotypes related to Plexiform Schwannoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 GFAP KIT NF1 B3GAT1 NF2 ENO2
2 cellular MP:0005384 9.91 GFAP KIT NF1 CD34 DSP ENO2
3 craniofacial MP:0005382 9.8 KIT NF1 NF2 DSP NGFR ENO2
4 digestive/alimentary MP:0005381 9.65 GFAP KIT NF1 DSP NGFR
5 integument MP:0010771 9.63 KIT NF1 CD34 NF2 DSP NGFR
6 nervous system MP:0003631 9.56 KIT NF1 B3GAT1 NF2 DSP NGFR
7 respiratory system MP:0005388 9.02 KIT NF1 NF2 ENO2 NGFR

Drugs & Therapeutics for Plexiform Schwannoma

Search Clinical Trials , NIH Clinical Center for Plexiform Schwannoma

Genetic Tests for Plexiform Schwannoma

Anatomical Context for Plexiform Schwannoma

MalaCards organs/tissues related to Plexiform Schwannoma:

38
Trachea, Tongue, Breast, Small Intestine

Publications for Plexiform Schwannoma

Articles related to Plexiform Schwannoma:

(show top 50) (show all 67)
# Title Authors Year
1
Percutaneous Image-Guided Cryotherapy for Local Control of Recurrent Plexiform Schwannoma in a 3-Year-Old Male. ( 28431654 )
2017
2
Plexiform Schwannoma of the Finger: A Case Report and Literature Review. ( 28979871 )
2017
3
Recurrent plexiform schwannoma involving the carotid canal. ( 28487042 )
2017
4
Congenital cellular plexiform schwannoma mimicking a vascular lesion: Potential pitfalls in clinical and histopathological assessment. ( 26728820 )
2016
5
Gastric plexiform schwannoma in association with neurofibromatosis type 2. ( 27696205 )
2016
6
Plexiform schwannoma of the thoracolumbar spine a rare clinical entity - a case report. ( 27809595 )
2016
7
Plexiform schwannoma: an unusual clitoral mass. ( 27818132 )
2016
8
Plexiform schwannoma of the posterior pharyngeal wall in a patient with neurofibromatosis 2. ( 25738721 )
2015
9
Plexiform schwannoma involving the trachea and recurrent laryngeal nerve: a case report. ( 26366364 )
2015
10
Oral plexiform schwannoma withA unusual epithelial induction. ( 26268670 )
2015
11
Congenital cellular plexiform schwannoma mimicking a vascular lesion: Potential pitfalls in clinical and histopathological assessment. ( 26658391 )
2015
12
Successful enucleation of large multinodular/plexiform schwannoma of the foot and ankle. ( 26090307 )
2015
13
Plexiform Schwannoma of Lumbar Region. ( 26064806 )
2015
14
A rare case of plexiform schwannoma of the lower lip: Treatment and management. ( 26424990 )
2015
15
Plexiform schwannoma of the rectum. ( 23363231 )
2014
16
Multinodular/plexiform schwannoma of the ulnar nerve. ( 24165375 )
2014
17
Plexiform schwannoma arising from cauda equina. ( 25264320 )
2014
18
Case presentations and review of plexiform schwannoma in the foot. ( 24556484 )
2014
19
Unusual intramaxillary plexiform schwannoma. ( 22847037 )
2013
20
Macrodactyly in the setting of a plexiform schwannoma in neurofibromatosis type 2: case report. ( 23453897 )
2013
21
Neuroimage: giant plexiform schwannoma of the penis. ( 23207604 )
2013
22
Plexiform schwannoma of the clitoris in a young girl: a case report. ( 23947092 )
2013
23
A rare case of life-threatening giant plexiform schwannoma. ( 22209242 )
2012
24
Plexiform schwannoma of the duodenum accompanying pyloric stenosis: report of a case. ( 22965512 )
2012
25
Plexiform Schwannoma of the nasal tip: surgical approach. ( 22714859 )
2012
26
Multiple plexiform schwannoma of a finger. ( 22266205 )
2012
27
A giant plexiform schwannoma of the brachial plexus: case report. ( 22044580 )
2011
28
Lobular breast carcinoma metastasis to a superficial plexiform schwannoma as the first evidence of an occult breast cancer. ( 22123192 )
2011
29
Plexiform schwannoma of the foot: a review of the literature and case report. ( 20833568 )
2011
30
Giant plexiform schwannoma of the tongue. ( 22937374 )
2011
31
Intraosseus plexiform schwannoma of the mandible: immunohistochemical differential diagnosis. ( 21119430 )
2010
32
Laryngeal plexiform schwannoma as first symptom in a patient with neurofibromatosis type 2. ( 20303213 )
2010
33
Plexiform schwannoma in schwannomatosis. ( 19884750 )
2009
34
Plexiform schwannoma of the esophagus in a child with neurofibromatosis type 2. ( 19573680 )
2009
35
Plexiform schwannoma of the posterior tibial nerve: a case report. ( 19918424 )
2009
36
Plexiform schwannoma of the lip mucosa. ( 19415817 )
2009
37
Plexiform schwannoma: a clinicopathologic overview with emphasis on the head and neck region. ( 18439936 )
2008
38
Cutaneous plexiform schwannoma of the finger not associated with neurofibromatosis. ( 18284268 )
2008
39
Isolated plexiform schwannoma of the hand. ( 21886708 )
2008
40
Congenital plexiform schwannoma of the clitoris. ( 18382807 )
2008
41
Intra-extradural plexiform schwannoma of the cervical spine. ( 17906563 )
2007
42
Plexiform schwannoma mimicking haemangioma: pitfalls in clinical diagnosis and histological interpretation. ( 17714565 )
2007
43
Plexiform schwannoma of the clitoris. ( 17614860 )
2007
44
Epithelioid angiosarcoma arising in a deep-seated plexiform schwannoma: a case report and literature review. ( 17574948 )
2007
45
Plexiform schwannoma of scalp: a case report with brief review of literature. ( 18306559 )
2007
46
Recurrent plexiform schwannoma in vestibular mucosa. ( 16681871 )
2006
47
Contiguous conventional and plexiform schwannomas. Report of two cases. ( 16509508 )
2006
48
Plexiform schwannoma of the ulnar nerve. ( 16019742 )
2005
49
Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety. ( 16006798 )
2005
50
Multiple plexiform schwannoma of the hand and forearm: a long-term follow-up. ( 15950336 )
2005

Variations for Plexiform Schwannoma

Expression for Plexiform Schwannoma

Search GEO for disease gene expression data for Plexiform Schwannoma.

Pathways for Plexiform Schwannoma

Pathways related to Plexiform Schwannoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.55 ENO2 GFAP NF1 NF2 NGFR
2 11.11 CD34 KIT NGFR

GO Terms for Plexiform Schwannoma

Cellular components related to Plexiform Schwannoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 desmosome GO:0030057 8.96 CDSN DSP
2 cell-cell junction GO:0005911 8.8 CDSN DSP KIT

Biological processes related to Plexiform Schwannoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.5 KIT NF1 NF2
2 pigmentation GO:0043473 9.37 KIT NF1
3 negative regulation of MAPK cascade GO:0043409 9.26 NF1 NF2
4 negative regulation of cell-matrix adhesion GO:0001953 9.16 NF1 NF2
5 intermediate filament organization GO:0045109 8.96 DSP GFAP
6 cell-cell adhesion GO:0098609 8.8 CD34 CDSN DSP

Sources for Plexiform Schwannoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
51 Novoseek
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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