MCID: PLM011
MIFTS: 35

Plummer's Disease malady

Categories: Endocrine diseases

Aliases & Classifications for Plummer's Disease

Aliases & Descriptions for Plummer's Disease:

Name: Plummer's Disease 12 14
Toxic Nodular Goiter 12 69
Toxic Nodular Goiter Unspecified 12
Toxic Nodular Goiter Nos 12
Goiter Toxic Nodular 52
Plummer Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11277
ICD10 33 E05.2
ICD9CM 35 242.3
NCIt 47 C35171
UMLS 69 C0342127

Summaries for Plummer's Disease

MalaCards based summary : Plummer's Disease, also known as toxic nodular goiter, is related to nodular goiter and goiter. An important gene associated with Plummer's Disease is TG (Thyroglobulin), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and Cell adhesion molecules (CAMs). The drugs Povidone-iodine and Antithyroid Agents have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Plummer's Disease

Diseases related to Plummer's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
id Related Disease Score Top Affiliating Genes
1 nodular goiter 11.5
2 goiter 10.6
3 graves' disease 10.3
4 thyroiditis 10.3
5 fibrous meningioma 10.2 TG TPO
6 neuhauser daly magnelli syndrome 10.2 TG TPO
7 premature closure of the arterial duct 10.2 TG TPO
8 background diabetic retinopathy 10.2 TG TPO
9 krabbe disease 10.2 TG TPO
10 frontal sinusitis 10.2 TG TPO
11 conjunctival deposit 10.2 TG TPO
12 caudal regression syndrome 10.2 TG TPO
13 color blindness 10.2 TG TPO
14 broad ligament malignant neoplasm 10.2 TG TPO
15 dysautonomia, familial 10.2 TG TPO
16 exanthema subitum 10.2 TG TPO
17 denys-drash syndrome 10.2 TG TPO
18 chromophobe adenoma 10.1 ICAM1 SELL
19 janus kinase-3 deficiency 10.1 TG TPO
20 hyperthyroidism 10.1
21 chromoblastomycosis 10.1 ICAM1 SELL
22 dihydrolipoamide dehydrogenase deficiency 10.1 TG TPO
23 tonsil cancer 10.1 ICAM1 SELE
24 hypopyon ulcer 10.1 ICAM1 SELE
25 perrault syndrome 10.1 ICAM1 SELL
26 macrodactyly of the foot 10.1 ICAM1 SELE
27 xerophthalmia 10.1 ICAM1 SELL
28 periosteal chondrosarcoma 10.1 ICAM1 SELE
29 sparganosis 10.1 ICAM1 SELE
30 peritoneal serous papillary adenocarcinoma 10.1 TG TPO
31 right ventricle hypoplasia 10.1 ICAM1 SELE
32 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.1 SELE SELL
33 prostate disease 10.1 ICAM1 SELE
34 lymph node disease 10.1 ICAM1 SELE
35 strawberry gallbladder 10.1 ICAM1 SELL
36 de quervain disease 10.1 SELE SELL
37 dermatomycosis 10.1 ICAM1 SELE
38 commensal bacterial infectious disease 10.1 TG TPO
39 nodular prostate 10.1 ICAM1 TG TPO
40 hypogonadism cardiomyopathy 10.1 SHBG TG
41 erb-duchenne and dejerine-klumpke palsies 10.1 ICAM1 SELE
42 diabetes mellitus, insulin-dependent, 12 10.0 ICAM1 TG TPO
43 powassan encephalitis 10.0 ICAM1 SELE
44 hypothyroidism, congenital, nongoitrous, 1 10.0 TG THRB TPO
45 dracunculiasis 10.0 ICAM1 SELE
46 autoimmune hemolytic anemia 10.0 TG THRB TPO
47 otosclerosis 10.0 TG THRB TPO
48 muscular dystrophy-dystroglycanopathy , type a, 10 10.0 TG THRB TPO
49 lobomycosis 10.0 ICAM1 SELE
50 peritoneal mesothelioma 10.0 TG THRB TPO

Graphical network of the top 20 diseases related to Plummer's Disease:



Diseases related to Plummer's Disease

Symptoms & Phenotypes for Plummer's Disease

MGI Mouse Phenotypes related to Plummer's Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 ICAM1 SELL TG THRB TPO
2 growth/size/body region MP:0005378 9.63 ICAM1 SELE SELL TG THRB TPO
3 hematopoietic system MP:0005397 9.43 ICAM1 SELE SELL TG THRB TPO
4 homeostasis/metabolism MP:0005376 9.1 ICAM1 SELE SELL TG THRB TPO

Drugs & Therapeutics for Plummer's Disease

Drugs for Plummer's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Povidone-iodine Approved Phase 4 25655-41-8
2 Antithyroid Agents Phase 4
3 Hormone Antagonists Phase 4
4 Hormones Phase 4
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
6 Anti-Infective Agents Phase 4,Phase 1
7 Anti-Infective Agents, Local Phase 4
8 cadexomer iodine Phase 4
9
Iodine Phase 4 7553-56-2 807
10 Povidone Phase 4
11
Chlorambucil Approved Phase 3 305-03-3 2708
12
Obinutuzumab Approved Phase 3 949142-50-1
13 Alkylating Agents Phase 3
14 Antineoplastic Agents, Alkylating Phase 3
15
Salmon Calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
16
Rucaparib Approved, Investigational Phase 2 283173-50-2 9931954
17 Poly(ADP-ribose) Polymerase Inhibitors Phase 2,Phase 1
18 Bone Density Conservation Agents Phase 2
19 calcitonin Phase 2
20 Calcitonin Gene-Related Peptide Phase 2
21 Antibodies Phase 1, Phase 2
22 Immunoglobulins Phase 1, Phase 2
23 Thromboplastin Phase 1, Phase 2
24
Olaparib Approved Phase 1 763113-22-0 23725625
25
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
26
Gemcitabine Approved Phase 1 95058-81-4 60750
27
Pemetrexed Approved, Investigational Phase 1 150399-23-8, 137281-23-3 446556 60843
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
29
leucovorin Approved, Nutraceutical Phase 1 58-05-9 54575, 6560146 143
30
Docetaxel Approved May 1996, Investigational Phase 1 114977-28-5 148124 9877265
31 Liver Extracts Phase 1
32 Antimetabolites Phase 1
33 Antimetabolites, Antineoplastic Phase 1
34 Antimitotic Agents Phase 1
35 Antiviral Agents Phase 1
36 Folic Acid Antagonists Phase 1
37 Immunosuppressive Agents Phase 1
38 Nucleic Acid Synthesis Inhibitors Phase 1
39 Vitamin B Complex Phase 1
40 Cola Nutraceutical Phase 1
41 Folate Nutraceutical Phase 1
42 Vitamin B9 Nutraceutical Phase 1
43 Analgesics
44 Peripheral Nervous System Agents

Interventional clinical trials:

(show all 27)
id Name Status NCT ID Phase
1 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4
2 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4
3 Dilute Betadine Lavage in the Prevention of Postoperative Infection Recruiting NCT01175044 Phase 4
4 A Study to Compare the Efficacy and Safety of Obinutuzumab + Venetoclax (GDC-0199) Versus Obinutuzumab + Chlorambucil in Participants With Chronic Lymphocytic Leukemia Active, not recruiting NCT02242942 Phase 3
5 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2
6 A Phase 1/2A Study of Minerval in Adult Patients With Advanced Solid Tumours Completed NCT01792310 Phase 1, Phase 2
7 Rucaparib(CO-338;Formally Called AG-014699 or PF-0136738) in Treating Patients With Locally Advanced or Metastatic Breast Cancer or Advanced Ovarian Cancer Completed NCT00664781 Phase 2
8 Phase 1/2a Study of Oral BAL101553 in Adult Patients With Solid Tumors or Glioblastoma or High-grade Glioma Recruiting NCT02490800 Phase 1, Phase 2
9 Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors Recruiting NCT02001623 Phase 1, Phase 2
10 Trial of Olaparib in Combination With AZD5363 (ComPAKT) Unknown status NCT02338622 Phase 1
11 Dose Escalating Study of Foxy-5 in Breast-, Colon- or Prostate Cancer Patients Recruiting NCT02655952 Phase 1
12 Safety and Tolerability of Collagenase Clostridium Histolyticum (EN3835) to Treat Uterine Leiomyoma (Fibroids) Recruiting NCT02889848 Phase 1
13 MSB0011359C (M7824) in Metastatic or Locally Advanced Solid Tumors Recruiting NCT02517398 Phase 1
14 A Phase I Trial of AZD3965 in Patients With Advanced Cancer Recruiting NCT01791595 Phase 1
15 A Phase 1 Trial of SRA737 in Subjects With Advanced Cancer Recruiting NCT02797964 Phase 1
16 First-in-Human Safety and Tolerability Study of MTL-CEBPA in Patients With Advanced Liver Cancer Recruiting NCT02716012 Phase 1
17 A Clinical Study on the Safety and Efficacy of Debio 0932 in Combination With Standard of Care in Patients With Non-small Cell Lung Cancer [NSCLC] Terminated NCT01714037 Phase 1
18 Opiate Sleep Disordered Breathing Study Unknown status NCT00791674
19 Cell Phone Intervention to Support Antiretroviral Therapy (ART) Adherence in Kenya Completed NCT00830622
20 Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism Recruiting NCT02005250
21 RADAR1- Trial of a New Blood Sample Method (Remote Arthritis Disease Activity MonitoR) Recruiting NCT02809547
22 Training Dual-Task Walking After Stroke Recruiting NCT01568957
23 Ultrasound Appearance of the Endometrium Post Radio-Frequency Ablation Recruiting NCT02584088
24 Pharmacogenomics Information in Enhancing Post-operative Total Joint Replacement Pain Management: a Pilot Study Recruiting NCT02711592
25 Comparison of Three Different Pain Blocks for Subjects Undergoing VATS (Video Assisted Thoracoscopic Surgery) Procedure. Recruiting NCT03151434
26 Expanding MRI Access for Patients With New and Existing ICDs and CRT-Ds ( ENABLE MRI) Recruiting NCT02652481
27 ReActiv8 for Chronic Low Back Pain Recruiting NCT01985230

Search NIH Clinical Center for Plummer's Disease

Genetic Tests for Plummer's Disease

Anatomical Context for Plummer's Disease

MalaCards organs/tissues related to Plummer's Disease:

39
Thyroid

Publications for Plummer's Disease

Articles related to Plummer's Disease:

(show all 30)
id Title Authors Year
1
Thyroid cancer in Plummer's disease. ( 23456166 )
2013
2
Intra-thyroid blood flow in Plummer's disease. ( 18520123 )
2008
3
Evidence-based management of toxic multinodular goiter (Plummer's Disease). ( 18357484 )
2008
4
Ventricular dysfunction in a patient with Plummer's disease: a case report. ( 12027234 )
2002
5
Generalized granuloma annulare associated with Plummer's disease. ( 12224712 )
2002
6
Current treatment of nodular goiter with hyperthyroidism (Plummer's disease): surgery versus radioiodine. ( 12490836 )
2002
7
Radioiodine therapy for Plummer's disease based on the thyroid uptake of technetium-99m pertechnetate. ( 11007508 )
2000
8
Plummer's disease with spontaneous progression to hypothyroidism. ( 10656280 )
1999
9
Diagnostic items and treatment of Plummer's disease: a study on 180 patients. ( 9842101 )
1998
10
Radioiodine treatment of Plummer's disease. ( 9867200 )
1998
11
Differentiated operative therapy of thyroid autonomy (Plummer's disease). ( 9867204 )
1998
12
Delayed radioiodine organification in Plummer's disease. ( 7750210 )
1995
13
Concurrent Plummer's disease and parathyroid adenoma. Diagnostic and therapeutic approaches to a difficult clinical problem. ( 8062469 )
1994
14
Symptomatology of Graves' disease and Plummer's disease in relation to age and thyroid hormone level. ( 8377872 )
1993
15
Unusual thyroid scintigrams in Plummer's disease during methimazole therapy. ( 2044327 )
1991
16
Unusual thyroid scintigrams in Plummer's disease during methimazole therapy. Conversion of hot to hypofunctional nodules. ( 2102667 )
1990
17
Plummer's disease. ( 3145821 )
1988
18
Long-term follow-up of patients with residual thyroid autonomy after surgical treatment of Plummer's disease. ( 2484893 )
1988
19
Use of ultrasonography to eliminate hemiagenesis of a thyroid lobe in the differential diagnosis of a toxic adenoma (Plummer's disease) ( 3280210 )
1988
20
Coexistence of a nonfunctioning thyroid nodule in Plummer's disease demonstrated by thallium-201 imaging. ( 3349711 )
1988
21
Plummer's disease: localized thyroid autonomy. ( 3294993 )
1987
22
Long-term follow-up in untreated Plummer's disease (autonomous goiter). ( 3829547 )
1987
23
Treatment of toxic multinodular goiter (Plummer's disease): surgery or radioiodine? ( 3751092 )
1986
24
Long-term follow-up after iodine-131 treatment for Plummer's disease (autonomous goiter). ( 3922656 )
1985
25
Autoimmunity and the pathogenesis of localized thyroid autonomy (Plummer's disease). ( 2869844 )
1985
26
Is partial thyroidectomy definitive treatment for Plummer's disease (autonomous goiter)? ( 6825357 )
1983
27
On the natural history of Plummer's disease. ( 582300 )
1979
28
Thyroid autonomy (Plummer's disease) with contralateral malignancy--mere coincidence? ( 1015361 )
1976
29
Plummer's disease. ( 1099364 )
1975
30
Nodular toxic goiter (Plummer's disease) in a child. ( 12119925 )
1974

Variations for Plummer's Disease

Expression for Plummer's Disease

Search GEO for disease gene expression data for Plummer's Disease.

Pathways for Plummer's Disease

GO Terms for Plummer's Disease

Biological processes related to Plummer's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.33 ICAM1 SELE SELL
2 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.26 ICAM1 SELE
3 leukocyte cell-cell adhesion GO:0007159 8.96 ICAM1 SELE
4 hormone biosynthetic process GO:0042446 8.62 TG TPO

Sources for Plummer's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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