MCID: PLM011
MIFTS: 38

Plummer's Disease

Categories: Endocrine diseases

Aliases & Classifications for Plummer's Disease

MalaCards integrated aliases for Plummer's Disease:

Name: Plummer's Disease 12 14
Toxic Nodular Goiter 12 69
Toxic Nodular Goiter Unspecified 12
Toxic Nodular Goiter Nos 12
Goiter Toxic Nodular 51
Plummer Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11277
ICD10 32 E05.2
ICD9CM 34 242.3
NCIt 46 C35171
UMLS 69 C0342127

Summaries for Plummer's Disease

MalaCards based summary : Plummer's Disease, also known as toxic nodular goiter, is related to nodular goiter and goiter. An important gene associated with Plummer's Disease is TG (Thyroglobulin), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and Cell adhesion molecules (CAMs). The drugs Antithyroid Agents and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid and bone, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Plummer's Disease

Diseases related to Plummer's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 nodular goiter 32.5 ICAM1 TG TPO
2 goiter 31.0 TG THRB TPO
3 thyroiditis 30.4 TG THRB TPO
4 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.4 TG TPO
5 toxic diffuse goiter 30.2 TG TPO
6 multinodular goiter 30.1 TG TPO
7 graves' disease 30.1 ICAM1 TG THRB TPO
8 hashimoto thyroiditis 29.8 ICAM1 TG TPO
9 graves disease 1 29.7 TG THRB TPO
10 hypothyroidism 29.6 SHBG TG TPO
11 thyroid cancer 29.5 TG THRB TPO
12 nontoxic goiter 29.4 SHBG TG TPO
13 hyperthyroidism 29.3 SHBG TG THRB TPO
14 familial thyroid dyshormonogenesis 10.3 TG TPO
15 subacute lymphocytic thyroiditis 10.3 TG TPO
16 neonatal hypothyroidism 10.3 TG TPO
17 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.3 TG TPO
18 endemic goiter 10.3 TG TPO
19 premature menopause 10.3 TG TPO
20 hypothyroidism, congenital, nongoitrous, 4 10.3 TG TPO
21 myxedema 10.3 TG TPO
22 pernicious anemia 10.3 TG TPO
23 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.3 TG TPO
24 follicular adenoma 10.2 TG TPO
25 toxicodendron dermatitis 10.2 ICAM1 SELL
26 pendred syndrome 10.2 TG TPO
27 congenital hypothyroidism 10.2 TG TPO
28 arthus reaction 10.1 ICAM1 SELL
29 hypersensitivity reaction disease 10.1 TG TPO
30 chronic venous insufficiency 10.1 ICAM1 SELL
31 heterophyiasis 10.1 ICAM1 SELE
32 papillary carcinoma 10.1 TG TPO
33 lymphocytic vasculitis 10.1 ICAM1 SELE
34 mooren's ulcer 10.1 ICAM1 SELE
35 venous insufficiency 10.1 ICAM1 SELL
36 hymenolepiasis 10.1 ICAM1 SELE
37 pleurisy 10.1 ICAM1 SELL
38 subendocardial myocardial infarction 10.1 ICAM1 SELE
39 actinic prurigo 10.1 ICAM1 SELE
40 endophthalmitis 10.1 ICAM1 SELE
41 rheumatoid vasculitis 10.1 ICAM1 SELE
42 hydrocele 10.1 ICAM1 SELE
43 hypersensitivity reaction type iii disease 10.1 ICAM1 SELE
44 boutonneuse fever 10.1 SELE SELL
45 cytomegalovirus infection 10.1 ICAM1 SELE
46 retinitis pigmentosa 60 10.1 SELE SELL
47 differentiated thyroid carcinoma 10.1 TG TPO
48 plasmodium vivax malaria 10.0 ICAM1 SELE
49 critical illness polyneuropathy 10.0 ICAM1 SELE
50 hypoadrenalism 10.0 SHBG TG

Graphical network of the top 20 diseases related to Plummer's Disease:



Diseases related to Plummer's Disease

Symptoms & Phenotypes for Plummer's Disease

MGI Mouse Phenotypes related to Plummer's Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 ICAM1 SELL TG THRB TPO
2 growth/size/body region MP:0005378 9.63 ICAM1 SELE SELL TG THRB TPO
3 hematopoietic system MP:0005397 9.43 ICAM1 SELE SELL TG THRB TPO
4 homeostasis/metabolism MP:0005376 9.1 ICAM1 SELE SELL TG THRB TPO

Drugs & Therapeutics for Plummer's Disease

Drugs for Plummer's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antithyroid Agents Phase 4
2 Hormone Antagonists Phase 4
3 Hormones Phase 4
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
5
Salmon Calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
6 Bone Density Conservation Agents Phase 2
7 calcitonin Phase 2
8 Calcitonin Gene-Related Peptide Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
2 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
3 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
4 Thumb-ECG Ambulant Screening for Atrial Fibrillation in Patients Treated for Hyperthyroidism (TAMBOURINE) Recruiting NCT01945229
5 Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism Recruiting NCT02005250

Search NIH Clinical Center for Plummer's Disease

Genetic Tests for Plummer's Disease

Anatomical Context for Plummer's Disease

MalaCards organs/tissues related to Plummer's Disease:

38
Thyroid, Bone

Publications for Plummer's Disease

Articles related to Plummer's Disease:

(show top 50) (show all 81)
# Title Authors Year
1
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter. ( 28471268 )
2017
2
Quality-of-Life Impairments Persist Six Months After Treatment of Graves' Hyperthyroidism and Toxic Nodular Goiter: A Prospective Cohort Study. ( 27370744 )
2016
3
Long-Term Results of Fixed High-Dose I-131 Treatment for Toxic Nodular Goiter: Higher Euthyroidism Rates in Geriatric Patients. ( 27529883 )
2015
4
Thyroid cancer in patients with toxic nodular goiter-is the incidence increasing? ( 25896315 )
2015
5
Graves Disease Induced by Radioiodine Therapy for Toxic Nodular Goiter: A Case Report. ( 27529890 )
2015
6
Effectiveness of Radioiodine Treatment for Toxic Nodular Goiter. ( 27529884 )
2015
7
Laser ablation and 131-iodine: a 24-month pilot study of combined treatment for large toxic nodular goiter. ( 24684455 )
2014
8
Efficacy of different protocols of radioiodine therapy for treatment of toxic nodular goiter: systematic review and meta-analysis of the literature. ( 24803943 )
2014
9
ANIMAL MODELS OF DISEASE: Feline hyperthyroidism: an animal model for toxic nodular goiter. ( 25297557 )
2014
10
Bone mineral density in geriatric patients with toxic nodular goiter. ( 25161096 )
2014
11
Toxic nodular goiter and cancer: a compelling case for thyroidectomy. ( 23108556 )
2013
12
Graves' disease and toxic nodular goiter are both associated with increased mortality but differ with respect to the cause of death: a Danish population-based register study. ( 23253072 )
2013
13
Thyroid cancer in Plummer's disease. ( 23456166 )
2013
14
Thyroid function: cause of increased mortality differs for Graves disease and toxic nodular goiter. ( 23318229 )
2013
15
Efficiency of radioactive I-131 therapy in geriatric patients with toxic nodular goiter. ( 23211880 )
2012
16
Efficacy of low and high fixed dose radioactive iodine therapy in patients with toxic nodular goiter. ( 21519320 )
2011
17
Progressive macular hypomelanosis arising in a young African American woman in association with pregnancy and a toxic nodular goiter. ( 20514800 )
2010
18
Toxic nodular goiter with thyroid papillary microcarcinoma. ( 20575904 )
2010
19
Evidence-based management of toxic multinodular goiter (Plummer's Disease). ( 18357484 )
2008
20
Comments regarding "Subclinical hyperthyroidism in cats: a spontaneous model of subclinical toxic nodular goiter in humans?". ( 19067644 )
2008
21
Intra-thyroid blood flow in Plummer's disease. ( 18520123 )
2008
22
Subclinical hyperthyroidism in cats: a spontaneous model of subclinical toxic nodular goiter in humans? ( 18177255 )
2007
23
Iodine-131 given for therapeutic purposes modulates differently interferon-gamma-inducible alpha-chemokine CXCL10 serum levels in patients with active Graves' disease or toxic nodular goiter. ( 17244787 )
2007
24
The occurrence of hypothyroidism following radioactive iodine treatment of toxic nodular goiter is related to the TSH level. ( 17632747 )
2007
25
[Soluble forms of adhesion molecules sELAM-1 and sICAM-1 in Graves disease and toxic nodular goiter]. ( 14768174 )
2003
26
Cytologic appearance of toxic nodular goiter after thyrostatic treatment. A karyometric study. ( 12630081 )
2003
27
A rare coexistence of primary hyperparathyroidism and hyperthyroidism due to toxic nodular goiter--a case report. ( 12879780 )
2003
28
Ventricular dysfunction in a patient with Plummer's disease: a case report. ( 12027234 )
2002
29
Generalized granuloma annulare associated with Plummer's disease. ( 12224712 )
2002
30
Current treatment of nodular goiter with hyperthyroidism (Plummer's disease): surgery versus radioiodine. ( 12490836 )
2002
31
Smoking as a risk factor for Graves' disease, toxic nodular goiter, and autoimmune hypothyroidism. ( 11838733 )
2002
32
False-positive suspicion of a thyroid metastatic lesion by In-111 pentetreotide uptake in a toxic nodular goiter. ( 11353323 )
2001
33
Serum levels of cytokines in children and adolescents with Graves' disease and non-toxic nodular goiter. ( 11453524 )
2001
34
Radioiodine therapy for Plummer's disease based on the thyroid uptake of technetium-99m pertechnetate. ( 11007508 )
2000
35
Plummer's disease with spontaneous progression to hypothyroidism. ( 10656280 )
1999
36
Differentiated operative therapy of thyroid autonomy (Plummer's disease). ( 9867204 )
1998
37
Cost analysis of surgical procedures for toxic nodular goiter. ( 9867202 )
1998
38
Toxic nodular goiter. Toxic adenoma and toxic multinodular goiter. ( 9534034 )
1998
39
Diagnostic items and treatment of Plummer's disease: a study on 180 patients. ( 9842101 )
1998
40
Sequential occurrence of toxic nodular goiter followed by Graves' disease. ( 15251744 )
1998
41
Radioiodine treatment of Plummer's disease. ( 9867200 )
1998
42
Toxic nodular goiter and thymic hyperplasia in an adult. Case report. ( 9557476 )
1997
43
Serum levels of the carboxy-terminal cross-linked telopeptide of type I collagen and laminin are elevated in Graves' disease but not in toxic nodular goiter. ( 7768039 )
1995
44
Delayed radioiodine organification in Plummer's disease. ( 7750210 )
1995
45
Depression and anxiety in an 85-year-old woman with a toxic nodular goiter. ( 7789785 )
1995
46
Etiopathology of feline toxic nodular goiter. ( 8053112 )
1994
47
Concurrent Plummer's disease and parathyroid adenoma. Diagnostic and therapeutic approaches to a difficult clinical problem. ( 8062469 )
1994
48
Serum selenium concentrations in patients with autoimmune thyroiditis and non-toxic nodular goiter. ( 7508739 )
1993
49
Symptomatology of Graves' disease and Plummer's disease in relation to age and thyroid hormone level. ( 8377872 )
1993
50
Unusual thyroid scintigrams in Plummer's disease during methimazole therapy. ( 2044327 )
1991

Variations for Plummer's Disease

Expression for Plummer's Disease

Search GEO for disease gene expression data for Plummer's Disease.

Pathways for Plummer's Disease

GO Terms for Plummer's Disease

Biological processes related to Plummer's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.33 ICAM1 SELE SELL
2 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.32 ICAM1 SELE
3 leukocyte cell-cell adhesion GO:0007159 9.26 ICAM1 SELE
4 leukocyte tethering or rolling GO:0050901 8.96 SELE SELL
5 hormone biosynthetic process GO:0042446 8.62 TG TPO

Molecular functions related to Plummer's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oligosaccharide binding GO:0070492 8.62 SELE SELL

Sources for Plummer's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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