MCID: PNM013
MIFTS: 55

Pneumococcal Meningitis malady

Neuronal diseases, Infectious diseases, Rare diseases categories
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Summaries for Pneumococcal Meningitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Pneumococcal infection refers to an infection caused by Streptococcus pneumoniae. more...

MalaCards: Pneumococcal Meningitis, also known as meningitis, pneumococcal, is related to meningitis and pneumonia. An important gene associated with Pneumococcal Meningitis is IRAK4 (interleukin-1 receptor-associated kinase 4), and among its related pathways are Plasma membrane estrogen receptor signaling and Angiogenesis. The compounds minocycline and trolox have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are muscle and tumorigenesis.

Aliases & Classifications for Pneumococcal Meningitis

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49Orphanet, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

pneumococcal meningitis 49
meningitis, pneumococcal 62


External Ids:

MESH via Orphanet36 D008586
ICD10 via Orphanet26 G00.1
SNOMED-CT via Orphanet59 51169003
UMLS via Orphanet63 C0025295
ICD1025 G00.1

Related Diseases for Pneumococcal Meningitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pneumococcal Meningitis:



Diseases related to pneumococcal meningitis

Symptoms for Pneumococcal Meningitis

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Drugs & Therapeutics for Pneumococcal Meningitis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pneumococcal Meningitis

Search NIH Clinical Center for Pneumococcal Meningitis

Genetic Tests for Pneumococcal Meningitis

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Anatomical Context for Pneumococcal Meningitis

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33MalaCards
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MalaCards organs/tissues related to Pneumococcal Meningitis:

33
Brain, Testes, Cortex, Endothelial, Bone, Spleen, Spinal cord, Myeloid

Animal Models for Pneumococcal Meningitis or affiliated genes

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37MGI
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Publications for Pneumococcal Meningitis

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52PubMed
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Articles related to Pneumococcal Meningitis:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis. (24248324)
2013
2
Death is associated with complement C3 depletion in cerebrospinal fluid of patients with pneumococcal meningitis. (22415003)
2012
3
Brain abscesses complicating acute pneumococcal meningitis during etanercept therapy. (22634540)
2012
4
Cerebral ischaemia in the context of improving, steroid-treated pneumococcal meningitis. (21493690)
2012
5
Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis. (21261959)
2011
6
Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. (20875857)
2011
7
The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release. (22003197)
2011
8
Treatment of Drug-resistant Pneumococcal Meningitis. (21308542)
2010
9
Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis? (20625175)
2010
10
High cerebrospinal fluid (CSF) penetration and potent bactericidal activity in CSF of NZ2114, a novel plectasin variant, during experimental pneumococcal meningitis. (19188395)
2009
11
Effect of pneumococcal conjugate vaccine on pneumococcal meningitis. (19144940)
2009
12
Effect of the NMDA-receptor antagonist dextromethorphan in infant rat pneumococcal meningitis. (18220575)
2008
13
Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. (18625913)
2008
14
Changing epidemiology of pneumococcal meningitis after the introduction of pneumococcal conjugate vaccine in the United States. (18433334)
2008
15
Late-onset rhabdomyolysis in pneumococcal meningitis: a case report. (17909699)
2007
16
Threshold shift: effects of cochlear implantation on the risk of pneumococcal meningitis. (17418257)
2007
17
Pneumococcal meningitis in community is frequent after craniocerebral trauma and in alcohol abusers. (18030267)
2007
18
Pneumococcal meningitis epidemics in Africa. (16912942)
2006
19
Clinical data and factors associated with poor outcome in pneumococcal meningitis. (16333641)
2006
20
Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury. (16956766)
2006
21
Gene expression in cortex and hippocampus during acute pneumococcal meningitis. (16749930)
2006
22
Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study. (16915106)
2006
23
C-reactive protein: a valuable acute investigation. A case of pneumococcal meningitis presenting as ankle pain. (16046777)
2005
24
Cerebral output of cytokines in patients with pneumococcal meningitis. (16276227)
2005
25
Penicillin-resistant pneumococcal meningitis: high antibiotic exposure impedes new vaccine protection. (15962556)
2005
26
Elevated cytokines in pneumococcal meningitis: Chicken or egg? (15891358)
2005
27
Reduction of astrogliosis by early treatment of pneumococcal meningitis measured by simultaneous imaging, in vivo, of the pathogen and host response. (16299273)
2005
28
Austrian syndrome in a child-aortic valve endocarditis following pneumococcal meningitis. (15094001)
2004
29
Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice. (11891827)
2002
30
Recurrence of pneumococcal meningitis due to primary spontaneous cerebrospinal fluid fistulas. (11820653)
2001
31
Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus. (10696140)
2000
32
Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis. (10479144)
1999
33
Endothelin B receptor-mediated increase of cerebral blood flow in experimental pneumococcal meningitis. (9428307)
1998
34
A possible secondary case of pneumococcal meningitis. (9892535)
1998
35
Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis. (9083551)
1997
36
Ultrastructural damage to the organ of corti during acute experimental Escherichia coli and pneumococcal meningitis in guinea pigs. (8790739)
1996
37
Pneumococcal meningitis in children: prognostic indicators and outcome. (8749621)
1995
38
Drug-resistant pneumococcal meningitis in an American adult. (7548521)
1995
39
Fatal pneumococcal meningitis in an HIV-infected drug user despite previous pneumococcal immunization. (8061097)
1994
40
Methylprednisolone attenuates inflammation, increase of brain water content and intracranial pressure, but does not influence cerebral blood flow changes in experimental pneumococcal meningitis. (8032946)
1994
41
A review of the clinical presentation, laboratory features, antimicrobial therapy and outcome of 77 episodes of pneumococcal meningitis occurring in children and adults. (7806880)
1994
42
Is nitric oxide involved as a mediator of cerebrovascular changes in the early phase of experimental pneumococcal meningitis? (7913993)
1994
43
Evaluation of antimicrobial regimens for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. (8215275)
1993
44
Mortality in pneumococcal meningitis: a multivariate analysis of prognostic factors. (8258002)
1993
45
Antibiotic resistance to pneumococcal meningitis. (1353601)
1992
46
Autosplenectomy complicating pneumococcal meningitis in adults. (1627041)
1992
47
Sequential bacteriological findings in the cerebrospinal fluid of Nigerian patients with pneumococcal meningitis. (3958504)
1986
48
Pneumococcal meningitis with purpura. (4055694)
1985
49
Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis. (6517548)
1984
50
Cerebral arteritis and phlebitis in pneumococcal meningitis. (20297306)
1946

Variations for Pneumococcal Meningitis

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Expression for genes affiliated with Pneumococcal Meningitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pneumococcal Meningitis

Search GEO for disease gene expression data for Pneumococcal Meningitis.

Pathways for genes affiliated with Pneumococcal Meningitis

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Sources:
50PathCards, 38NCBI BioSystems Database, 5Cell Signaling Technology, 60Thomson Reuters, 53QIAGEN, 55Reactome, 30KEGG, 57SinoBiological, 54R&D Systems
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Pathways related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MMP9, SRC
2
Show member pathways
Angiogenesis38
9.7SRC, MMP9
39.7CASP3, CASP1
49.7TNFRSF1B, CASP3
59.5IL6, MMP9
69.5SRC, CASP3
7
Show member pathways
9.4CASP1, CASP3, IRAK4
89.4SRC, MMP9, TNFRSF1B
9
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.4TNFRSF1B, CASP3, CASP1
109.4TNFRSF1B, CASP3, CASP1
119.3CASP3, IL6
12
Show member pathways
9.3CASP1, IL6, IRAK4
13
Show member pathways
9.3IL6, IRAK4, TNFRSF1B
14
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.3SRC, MMP9, HSPA1A
15
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3CASP3, SRC, IRAK4
16
Show member pathways
thioredoxin pathway38
9.2KMO, IL6, CAT
179.2SRC, CASP3, CASP1
18
Show member pathways
Alternative NF-kappaB pathway38
9.2CASP3, SRC, TNFRSF1B
199.2SRC, C3, CASP3
209.2C5, IL6, HSPA1A
219.2CASP3, SRC, MMP9
22
Show member pathways
9.1SRC, IL6, CASP1
23
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.1MBL2, C5, C3
249.1MBL2, C5, C3
25
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.1C3, C5, MBL2
269.1MMP9, SRC, IL6
27
Show member pathways
Amyotrophic lateral sclerosis (ALS)38
9.0CAT, CASP1, CASP3, TNFRSF1B
289.0CASP3, IL6, MMP9
29
Show member pathways
9.0IRAK4, SRC, CASP3, CASP1
30
Show member pathways
8.9CASP1, CASP3, SRC, TNFRSF1B
318.9MMP9, IRAK4, SRC, CASP3
32
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.9IRAK4, SRC, IL6, CASP1
33
Show member pathways
8.7CASP1, CASP3, IRAK4, HSPA1A, TNFRSF1B
348.7TNFRSF1B, MMP9, IL6, CASP3
35
Show member pathways
8.6TNFRSF1B, HSPA1A, IL6, CASP3
36
Show member pathways
8.6MBL2, C5, C3, SRC
378.5MMP9, SRC, IL6, CASP3
388.5MMP9, SRC, IL6, CASP3
39
Show member pathways
8.4HSPA1A, IRAK4, IL6, C3, CASP3
40
Show member pathways
8.3TNFRSF1B, IRAK4, SRC, IL6, CASP3
41
Show member pathways
8.3TNFRSF1B, IRAK4, SRC, IL6, CASP3
428.3HSPA1A, IL6, C3, CASP3, CASP1
438.3IRAK4, SRC, IL6, C3, CASP3
44
Show member pathways
8.3TNFRSF1B, SRC, IL6, CASP3, CASP1
458.2C5, CASP1, CASP3, C3, IL6, IRAK4
46
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
8.0TNFRSF1B, HSPA1A, MMP9, IL6, CASP3, CASP1
47
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.0MMP9, IRAK4, SRC, IL6, C3, CASP3
48
Show member pathways
7.9TNFRSF1B, MMP9, SRC, IL6, CASP3, CASP1
49
Show member pathways
7.9TNFRSF1B, HSPA1A, SRC, IL6, CASP3, CASP1
50
Show member pathways
7.8HSPA1A, IRAK4, IL6, C3, CASP3, CASP1

Compounds for genes affiliated with Pneumococcal Meningitis

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Sources:
45Novoseek, 11DrugBank, 3BitterDB, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 51PharmGKB
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Compounds related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1minocycline45 1110.7CASP1, MMP9, CASP3
2trolox459.7CASP1, CASP3, CAT
3staurosporin459.6SRC, CASP1, CASP3
4dutp459.5CASP1, CASP3, TNFRSF1B
5anaphylatoxin459.5C3, IL6, C5
6s-nitroso-n-acetylpenicillamine459.5CAT, CASP1, CASP3
7helenalin459.4SRC, MMP9, IL6
8alpha lipoic acid459.4MMP9, HSPA1A, CAT
9tpck459.4CASP1, IL6, CASP3
10parthenolide45 310.3CASP3, IL6, MMP9
11diphenyleneiodonium459.2CASP3, CASP1, CAT, SRC
12ciglitazone45 2910.2MMP9, IL6, CASP3
13quercetin45 61 24 1112.2HSPA1A, CASP3, CAT, CASP1
14rotenone459.2CASP3, CASP1, CAT
15endotoxin459.2HSPA1A, TNFRSF1B, IL6, CASP1
168-isoprostane459.1CAT, HSPA1A, MMP9, IL6
17pdtc459.0CAT, IL6, CASP3, MMP9
18zoledronic acid459.0CASP3, MMP9, IL6, SRC
195fluorouracil458.9CASP1, CASP3, SRC, TNFRSF1B
20neopterin458.8TNFRSF1B, MBL2, C3, IL6
21pge2458.8TNFRSF1B, SRC, IL6, MMP9, CASP1
22peptidoglycan45 299.7IL6, CASP1, MBL2
23cisplatin45 51 61 1111.7CASP1, CASP3, SRC, HSPA1A, TNFRSF1B
24norepinephrine45 24 1110.7TNFRSF1B, HSPA1A, MMP9, SRC, IL6
25ly294002458.6TNFRSF1B, MMP9, SRC, IL6, CASP3
26arsenite45 249.5HSPA1A, CAT, CASP1, CASP3, MMP9, SRC
27h2o2458.5TNFRSF1B, CAT, CASP1, CASP3, SRC, HSPA1A
28fibrinogen458.4IL6, C3, TNFRSF1B, MBL2, MMP9
29aspartate458.4MBL2, CASP1, MMP9, HSPA1A, SRC
30curcumin458.3IL6, MMP9, CAT, CASP3, SRC, TNFRSF1B
31pd 98,059458.3CASP1, HSPA1A, SRC, IL6, CASP3, MMP9
32superoxide45 249.2HSPA1A, MBL2, TNFRSF1B, CASP3, CASP1, CAT
33rantes458.1MBL2, IL6, MMP9, TNFRSF1B
34creatinine458.1HSPA1A, MBL2, CASP1, C3, IL6, MMP9
35actinomycin d458.1TNFRSF1B, CAT, CASP1, HSPA1A, CASP3, IL6
36cycloheximide458.0CAT, CASP1, CASP3, IL6, MMP9, HSPA1A
37lactate458.0CASP1, CASP3, IL6, C3, CAT, MMP9
38nitric oxide45 24 1110.0CAT, IL6, HSPA1A, TNFRSF1B, CASP1, MBL2
39cyclosporin a45 29 6110.0TNFRSF1B, IL6, MMP9, CASP3, SRC, CASP1
40n acetylcysteine457.9SRC, MMP9, IL6, CASP3, CASP1, CAT
41sb 20358045 618.9CASP1, CASP3, IL6, SRC, CAT, MMP9
42glucose457.9HSPA1A, IL6, TNFRSF1B, C3, CASP1, MBL2
43lipid457.7IL6, C3, CASP1, CAT, MBL2, TNFRSF1B
44serine457.6IRAK4, MMP9, TNFRSF1B, CASP1, CASP3, C3
45vegf457.5TNFRSF1B, MMP9, MBL2, SRC, CASP3, CASP1
46cysteine457.5SRC, MMP9, MBL2, CAT, TNFRSF1B, CASP1
47oxygen45 248.4MBL2, IRAK4, CAT, TNFRSF1B, HSPA1A, KMO
48dexamethasone45 51 29 1110.4MMP9, C3, IL6, SRC, HSPA1A, TNFRSF1B
49tyrosine457.3CASP1, TNFRSF1B, HSPA1A, MMP9, MBL2, IL6
50estrogen457.3HSPA1A, MMP9, SRC, TNFRSF1B, C3, CASP1

GO Terms for genes affiliated with Pneumococcal Meningitis

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16Gene Ontology
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Cellular components related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1MBL2, C5, C3, IL6, MMP9
2extracellular regionGO:0055766.7MBL2, TNFRSF1B, MMP9, LGALS9, IL6, C3

Biological processes related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:00695710.1C5, C3
2positive regulation vascular endothelial growth factor productionGO:01057510.0C5, C3
3regulation of complement activationGO:03044910.0C5, C3
4execution phase of apoptosisGO:0971949.6CASP1, CASP3
5positive regulation of phagocytosisGO:0507669.4MBL2, C3
6proteolysisGO:0065089.3MMP9, CASP3, CASP1
7complement activationGO:0069569.3MBL2, C5, C3
8complement activation, classical pathwayGO:0069589.3C3, C5, MBL2
9inflammatory responseGO:0069549.2C5, C3, IL6, TNFRSF1B
10acute-phase responseGO:0069539.0MBL2, IL6
11defense response to Gram-positive bacteriumGO:0508308.7MBL2, IL6
12negative regulation of apoptotic processGO:0430668.7SRC, IL6, CASP3, CAT
13innate immune responseGO:0450878.4MBL2, IRAK4, SRC, C3, CASP1, C5

Molecular functions related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.9C5, C3
2receptor bindingGO:0051028.1MBL2, C5, CAT, C3, SRC
3protein bindingGO:0055156.0SRC, IRAK4, MMP9, TNFRSF1B, IL6, C3

Products for genes affiliated with Pneumococcal Meningitis

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  • Antibodies
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  • Antibodies

Sources for Pneumococcal Meningitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet