MCID: PNM013
MIFTS: 47

Pneumococcal Meningitis malady

Neuronal diseases, Infectious diseases, Rare diseases categories

Aliases & Classifications for Pneumococcal Meningitis

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Sources:
47Orphanet, 60UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Pneumococcal Meningitis, Aliases & Descriptions:

Name: Pneumococcal Meningitis 47
 
Meningitis, Pneumococcal 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases
Anatomical: Neuronal diseases


External Ids:

Orphanet47 55655
MESH via Orphanet34 D008586
ICD10 via Orphanet26 G00.1
UMLS via Orphanet61 C0025295
ICD1025 G00.1

Summaries for Pneumococcal Meningitis

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MalaCards based summary: Pneumococcal Meningitis, also known as meningitis, pneumococcal, is related to meningitis and bacteremia. An important gene associated with Pneumococcal Meningitis is IRAK4 (interleukin-1 receptor-associated kinase 4), and among its related pathways are Plasma membrane estrogen receptor signaling and Angiogenesis. The compounds minocycline and trolox have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are muscle and tumorigenesis.

Related Diseases for Pneumococcal Meningitis

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Diseases related to Pneumococcal Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis31.7CAT, IL6, IRAK4, MMP9, MBL2
2bacteremia31.1MBL2, CAT
3vasculitis30.7TNFRSF1B, C3, MBL2
4pneumonia30.7IL6, TNFRSF1B, MBL2
5glomerulonephritis30.3C3, MBL2, CAT
6ischemia29.5CAT, CASP1, CASP3, HSPA1A, KMO, SRC
7arthritis29.4CASP1, IL6, C3, TNFRSF1B, MMP9, SRC
8cerebritis10.7
9neuronitis10.6
10conjunctivochalasis10.5MMP9
11brain edema10.5
12rheumatic heart disease10.4MBL2
13meningioma, familial10.4SRC
14endocarditis10.4
15cryptosporidiosis10.4MBL2
16abdominal aortic aneurysm10.4MMP9
17huntington disease10.4CASP3
18brain injury10.3
19quadriplegia10.3
20transient cerebral ischemia10.3KMO, HSPA1A
21membranoproliferative glomerulonephritis10.3C3, MBL2
22neisseria meningitidis infection10.3MBL2, C3
23common variable immunodeficiency10.3
24labyrinthitis10.3
25otitis media10.3
26sickle cell disease10.3
27endotheliitis10.3
28kawasaki disease10.2MBL2, MMP9
29cowpox10.2CASP1, CASP3
30complement deficiency10.2C3, MBL2, C5
31synovitis10.2TNFRSF1B, IL6
32connective tissue disease10.2C3, IL6
33tuberculosis10.1MBL2, TNFRSF1B, C3
34fibrosarcoma10.1TNFRSF1B, MMP9, HSPA1A
35pulmonary tuberculosis10.1MBL2, C3, CAT
36west nile virus10.1
37c3 deficiency10.1
38alcohol abuse10.1
39hepatitis10.1
40sinusitis10.1
41hepatitis c10.1
42acquired immunodeficiency syndrome10.1
43nasopharyngitis10.1
44pyomyositis10.1
45chickenpox10.1
46locked-in syndrome10.1
47cauda equina syndrome10.1
48streptococcal meningitis10.1
49hemolytic-uremic syndrome10.1
50epidural abscess10.1

Graphical network of the top 20 diseases related to Pneumococcal Meningitis:



Diseases related to pneumococcal meningitis

Symptoms for Pneumococcal Meningitis

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Drugs & Therapeutics for Pneumococcal Meningitis

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Drug clinical trials:

Search ClinicalTrials for Pneumococcal Meningitis

Search NIH Clinical Center for Pneumococcal Meningitis

Genetic Tests for Pneumococcal Meningitis

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Anatomical Context for Pneumococcal Meningitis

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MalaCards organs/tissues related to Pneumococcal Meningitis:

31
Brain, Testes, Cortex, Endothelial, Neutrophil, Bone, Spleen, Spinal cord, Myeloid

Animal Models for Pneumococcal Meningitis or affiliated genes

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Publications for Pneumococcal Meningitis

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Articles related to Pneumococcal Meningitis:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
Intrathecal application of the antimicrobial peptide CRAMP reduced mortality and neuroinflammation in an experimental model of pneumococcal meningitis. (25896094)
2015
2
Pneumococcal meningitis-associated pyogenic ventriculitis. (25452044)
2015
3
Chickenpox complicated by pneumococcal meningitis: A rare coinfection. (25282451)
2014
4
Vitamin B6 prevents cognitive impairment in experimental pneumococcal meningitis. (24903161)
2014
5
Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis. (24248324)
2013
6
Death is associated with complement C3 depletion in cerebrospinal fluid of patients with pneumococcal meningitis. (22415003)
2012
7
Brain abscesses complicating acute pneumococcal meningitis during etanercept therapy. (22634540)
2012
8
Cerebral ischaemia in the context of improving, steroid-treated pneumococcal meningitis. (21493690)
2012
9
Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis. (21261959)
2011
10
Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. (20875857)
2011
11
Treatment of Drug-resistant Pneumococcal Meningitis. (21308542)
2010
12
Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis? (20625175)
2010
13
High cerebrospinal fluid (CSF) penetration and potent bactericidal activity in CSF of NZ2114, a novel plectasin variant, during experimental pneumococcal meningitis. (19188395)
2009
14
Effect of the NMDA-receptor antagonist dextromethorphan in infant rat pneumococcal meningitis. (18220575)
2008
15
Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. (18625913)
2008
16
Late-onset rhabdomyolysis in pneumococcal meningitis: a case report. (17909699)
2007
17
Threshold shift: effects of cochlear implantation on the risk of pneumococcal meningitis. (17418257)
2007
18
Pneumococcal meningitis in community is frequent after craniocerebral trauma and in alcohol abusers. (18030267)
2007
19
Pneumococcal meningitis epidemics in Africa. (16912942)
2006
20
Clinical data and factors associated with poor outcome in pneumococcal meningitis. (16333641)
2006
21
Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury. (16956766)
2006
22
Gene expression in cortex and hippocampus during acute pneumococcal meningitis. (16749930)
2006
23
Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study. (16915106)
2006
24
C-reactive protein: a valuable acute investigation. A case of pneumococcal meningitis presenting as ankle pain. (16046777)
2005
25
Cerebral output of cytokines in patients with pneumococcal meningitis. (16276227)
2005
26
Penicillin-resistant pneumococcal meningitis: high antibiotic exposure impedes new vaccine protection. (15962556)
2005
27
Elevated cytokines in pneumococcal meningitis: Chicken or egg? (15891358)
2005
28
Austrian syndrome in a child-aortic valve endocarditis following pneumococcal meningitis. (15094001)
2004
29
Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice. (11891827)
2002
30
Recurrence of pneumococcal meningitis due to primary spontaneous cerebrospinal fluid fistulas. (11820653)
2001
31
Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus. (10696140)
2000
32
Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis. (10479144)
1999
33
Endothelin B receptor-mediated increase of cerebral blood flow in experimental pneumococcal meningitis. (9428307)
1998
34
A possible secondary case of pneumococcal meningitis. (9892535)
1998
35
Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis. (9083551)
1997
36
Ultrastructural damage to the organ of corti during acute experimental Escherichia coli and pneumococcal meningitis in guinea pigs. (8790739)
1996
37
Pneumococcal meningitis in children: prognostic indicators and outcome. (8749621)
1995
38
Drug-resistant pneumococcal meningitis in an American adult. (7548521)
1995
39
Fatal pneumococcal meningitis in an HIV-infected drug user despite previous pneumococcal immunization. (8061097)
1994
40
Methylprednisolone attenuates inflammation, increase of brain water content and intracranial pressure, but does not influence cerebral blood flow changes in experimental pneumococcal meningitis. (8032946)
1994
41
A review of the clinical presentation, laboratory features, antimicrobial therapy and outcome of 77 episodes of pneumococcal meningitis occurring in children and adults. (7806880)
1994
42
Is nitric oxide involved as a mediator of cerebrovascular changes in the early phase of experimental pneumococcal meningitis? (7913993)
1994
43
Evaluation of antimicrobial regimens for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. (8215275)
1993
44
Mortality in pneumococcal meningitis: a multivariate analysis of prognostic factors. (8258002)
1993
45
Antibiotic resistance to pneumococcal meningitis. (1353601)
1992
46
Autosplenectomy complicating pneumococcal meningitis in adults. (1627041)
1992
47
Sequential bacteriological findings in the cerebrospinal fluid of Nigerian patients with pneumococcal meningitis. (3958504)
1986
48
Pneumococcal meningitis with purpura. (4055694)
1985
49
Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis. (6517548)
1984
50
Cerebral arteritis and phlebitis in pneumococcal meningitis. (20297306)
1946

Variations for Pneumococcal Meningitis

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Expression for genes affiliated with Pneumococcal Meningitis

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Search GEO for disease gene expression data for Pneumococcal Meningitis.

Pathways for genes affiliated with Pneumococcal Meningitis

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Pathways related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MMP9, SRC
2
Show member pathways
Angiogenesis36
9.7SRC, MMP9
39.7CASP3, CASP1
49.7TNFRSF1B, CASP3
59.5IL6, MMP9
69.5SRC, CASP3
7
Show member pathways
9.4CASP1, CASP3, IRAK4
89.4SRC, MMP9, TNFRSF1B
9
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.4TNFRSF1B, CASP3, CASP1
109.4TNFRSF1B, CASP3, CASP1
119.3CASP3, IL6
12
Show member pathways
9.3CASP1, IL6, IRAK4
13
Show member pathways
9.3IL6, IRAK4, TNFRSF1B
14
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
9.3SRC, MMP9, HSPA1A
15
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.3CASP3, SRC, IRAK4
16
Show member pathways
thioredoxin pathway36
9.2KMO, IL6, CAT
179.2SRC, CASP3, CASP1
18
Show member pathways
Alternative NF-kappaB pathway36
9.2CASP3, SRC, TNFRSF1B
199.2SRC, C3, CASP3
209.2C5, IL6, HSPA1A
219.2CASP3, SRC, MMP9
22
Show member pathways
9.1SRC, IL6, CASP1
23
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.1MBL2, C5, C3
249.1MBL2, C5, C3
25
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.1C3, C5, MBL2
269.1MMP9, SRC, IL6
27
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
9.0CAT, CASP1, CASP3, TNFRSF1B
289.0CASP3, IL6, MMP9
29
Show member pathways
9.0IRAK4, SRC, CASP3, CASP1
30
Show member pathways
8.9CASP1, CASP3, SRC, TNFRSF1B
318.9MMP9, IRAK4, SRC, CASP3
32
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.9IRAK4, SRC, IL6, CASP1
33
Show member pathways
8.7CASP1, CASP3, IRAK4, HSPA1A, TNFRSF1B
348.7TNFRSF1B, MMP9, IL6, CASP3
35
Show member pathways
8.6TNFRSF1B, HSPA1A, IL6, CASP3
36
Show member pathways
8.6MBL2, C5, C3, SRC
378.5MMP9, SRC, IL6, CASP3
388.5MMP9, SRC, IL6, CASP3
39
Show member pathways
8.4HSPA1A, IRAK4, IL6, C3, CASP3
40
Show member pathways
8.3TNFRSF1B, IRAK4, SRC, IL6, CASP3
41
Show member pathways
8.3TNFRSF1B, IRAK4, SRC, IL6, CASP3
428.3HSPA1A, IL6, C3, CASP3, CASP1
438.3IRAK4, SRC, IL6, C3, CASP3
44
Show member pathways
8.3TNFRSF1B, SRC, IL6, CASP3, CASP1
458.2C5, CASP1, CASP3, C3, IL6, IRAK4
46
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.0TNFRSF1B, HSPA1A, MMP9, IL6, CASP3, CASP1
47
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.0MMP9, IRAK4, SRC, IL6, C3, CASP3
48
Show member pathways
7.9TNFRSF1B, MMP9, SRC, IL6, CASP3, CASP1
49
Show member pathways
7.9TNFRSF1B, HSPA1A, SRC, IL6, CASP3, CASP1
50
Show member pathways
7.8HSPA1A, IRAK4, IL6, C3, CASP3, CASP1

Compounds for genes affiliated with Pneumococcal Meningitis

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Compounds related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1minocycline43 1210.7CASP1, MMP9, CASP3
2trolox439.7CASP1, CASP3, CAT
3staurosporin439.6SRC, CASP1, CASP3
4dutp439.5CASP1, CASP3, TNFRSF1B
5anaphylatoxin439.5C3, IL6, C5
6s-nitroso-n-acetylpenicillamine439.5CAT, CASP1, CASP3
7helenalin439.4SRC, MMP9, IL6
8alpha lipoic acid439.4MMP9, HSPA1A, CAT
9tpck439.4CASP1, IL6, CASP3
10parthenolide43 210.3CASP3, IL6, MMP9
11diphenyleneiodonium439.2CASP3, CASP1, CAT, SRC
12ciglitazone43 2810.2MMP9, IL6, CASP3
13quercetin43 59 24 1212.2HSPA1A, CASP3, CAT, CASP1
14rotenone439.2CASP3, CASP1, CAT
15endotoxin439.2HSPA1A, TNFRSF1B, IL6, CASP1
168-isoprostane439.1CAT, HSPA1A, MMP9, IL6
17pdtc439.0CAT, IL6, CASP3, MMP9
18zoledronic acid439.0CASP3, MMP9, IL6, SRC
195fluorouracil438.9CASP1, CASP3, SRC, TNFRSF1B
20neopterin438.8TNFRSF1B, MBL2, C3, IL6
21pge2438.8TNFRSF1B, SRC, IL6, MMP9, CASP1
22peptidoglycan43 289.7IL6, CASP1, MBL2
23cisplatin43 49 59 1211.7CASP1, CASP3, SRC, HSPA1A, TNFRSF1B
24norepinephrine43 24 1210.7TNFRSF1B, HSPA1A, MMP9, SRC, IL6
25ly294002438.6TNFRSF1B, MMP9, SRC, IL6, CASP3
26arsenite43 249.5HSPA1A, CAT, CASP1, CASP3, MMP9, SRC
27h2o2438.5TNFRSF1B, CAT, CASP1, CASP3, SRC, HSPA1A
28fibrinogen438.4IL6, C3, TNFRSF1B, MBL2, MMP9
29aspartate438.4MBL2, CASP1, MMP9, HSPA1A, SRC
30curcumin438.3IL6, MMP9, CAT, CASP3, SRC, TNFRSF1B
31pd 98,059438.3CASP1, HSPA1A, SRC, IL6, CASP3, MMP9
32superoxide43 249.2HSPA1A, MBL2, TNFRSF1B, CASP3, CASP1, CAT
33rantes438.1MBL2, IL6, MMP9, TNFRSF1B
34creatinine438.1HSPA1A, MBL2, CASP1, C3, IL6, MMP9
35actinomycin d438.1TNFRSF1B, CAT, CASP1, HSPA1A, CASP3, IL6
36cycloheximide438.0CAT, CASP1, CASP3, IL6, MMP9, HSPA1A
37lactate438.0CASP1, CASP3, IL6, C3, CAT, MMP9
38nitric oxide43 24 1210.0CAT, IL6, HSPA1A, TNFRSF1B, CASP1, MBL2
39cyclosporin a43 28 5910.0TNFRSF1B, IL6, MMP9, CASP3, SRC, CASP1
40n acetylcysteine437.9SRC, MMP9, IL6, CASP3, CASP1, CAT
41sb 20358043 598.9CASP1, CASP3, IL6, SRC, CAT, MMP9
42glucose437.9HSPA1A, IL6, TNFRSF1B, C3, CASP1, MBL2
43lipid437.7IL6, C3, CASP1, CAT, MBL2, TNFRSF1B
44serine437.6IRAK4, MMP9, TNFRSF1B, CASP1, CASP3, C3
45vegf437.5TNFRSF1B, MMP9, MBL2, SRC, CASP3, CASP1
46cysteine437.5SRC, MMP9, MBL2, CAT, TNFRSF1B, CASP1
47oxygen43 248.4MBL2, IRAK4, CAT, TNFRSF1B, HSPA1A, KMO
48dexamethasone43 49 28 1210.4MMP9, C3, IL6, SRC, HSPA1A, TNFRSF1B
49tyrosine437.3CASP1, TNFRSF1B, HSPA1A, MMP9, MBL2, IL6
50estrogen437.3HSPA1A, MMP9, SRC, TNFRSF1B, C3, CASP1

GO Terms for genes affiliated with Pneumococcal Meningitis

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Cellular components related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1MBL2, C5, C3, IL6, MMP9
2extracellular regionGO:00055766.7MBL2, TNFRSF1B, MMP9, LGALS9, IL6, C3

Biological processes related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:000695710.1C5, C3
2positive regulation vascular endothelial growth factor productionGO:001057510.0C5, C3
3regulation of complement activationGO:003044910.0C5, C3
4execution phase of apoptosisGO:00971949.6CASP1, CASP3
5positive regulation of phagocytosisGO:00507669.4MBL2, C3
6proteolysisGO:00065089.3MMP9, CASP3, CASP1
7complement activationGO:00069569.3MBL2, C5, C3
8complement activation, classical pathwayGO:00069589.3C3, C5, MBL2
9inflammatory responseGO:00069549.2C5, C3, IL6, TNFRSF1B
10acute-phase responseGO:00069539.0MBL2, IL6
11defense response to Gram-positive bacteriumGO:00508308.7MBL2, IL6
12negative regulation of apoptotic processGO:00430668.7SRC, IL6, CASP3, CAT
13innate immune responseGO:00450878.4MBL2, IRAK4, SRC, C3, CASP1, C5

Molecular functions related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00048669.9C5, C3
2receptor bindingGO:00051028.1MBL2, C5, CAT, C3, SRC
3protein bindingGO:00055156.0SRC, IRAK4, MMP9, TNFRSF1B, IL6, C3

Products for genes affiliated with Pneumococcal Meningitis

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Sources for Pneumococcal Meningitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet