MCID: PNM013
MIFTS: 47

Pneumococcal Meningitis malady

Neuronal diseases, Infectious diseases, Rare diseases categories

Aliases & Classifications for Pneumococcal Meningitis

About this section
Sources:
48Orphanet, 61UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Pneumococcal Meningitis:

Name: Pneumococcal Meningitis 48
 
Meningitis, Pneumococcal 61


Classifications:



External Ids:

Orphanet48 55655
MESH via Orphanet34 D008586
ICD10 via Orphanet26 G00.1
UMLS via Orphanet62 C0025295
ICD1025 G00.1

Summaries for Pneumococcal Meningitis

About this section
MalaCards based summary: Pneumococcal Meningitis, also known as meningitis, pneumococcal, is related to meningitis and bacteremia. An important gene associated with Pneumococcal Meningitis is IRAK4 (interleukin-1 receptor-associated kinase 4), and among its related pathways are Plasma membrane estrogen receptor signaling and Angiogenesis. The compounds minocycline and trolox have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are muscle and tumorigenesis.

Related Diseases for Pneumococcal Meningitis

About this section

Diseases related to Pneumococcal Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis31.7CAT, IL6, IRAK4, MMP9, MBL2
2bacteremia31.1MBL2, CAT
3vasculitis30.7TNFRSF1B, C3, MBL2
4pneumonia30.7IL6, TNFRSF1B, MBL2
5glomerulonephritis30.3C3, MBL2, CAT
6ischemia29.5CAT, CASP1, CASP3, HSPA1A, KMO, SRC
7arthritis29.4CASP1, IL6, C3, TNFRSF1B, MMP9, SRC
8cerebritis10.7
9neuronitis10.6
10conjunctivochalasis10.5MMP9
11brain edema10.5
12rheumatic heart disease10.4MBL2
13meningioma, familial10.4SRC
14endocarditis10.4
15cryptosporidiosis10.4MBL2
16abdominal aortic aneurysm10.4MMP9
17huntington disease10.4CASP3
18brain injury10.3
19quadriplegia10.3
20transient cerebral ischemia10.3KMO, HSPA1A
21membranoproliferative glomerulonephritis10.3C3, MBL2
22neisseria meningitidis infection10.3MBL2, C3
23common variable immunodeficiency10.3
24labyrinthitis10.3
25otitis media10.3
26sickle cell disease10.3
27endotheliitis10.3
28kawasaki disease10.2MBL2, MMP9
29cowpox10.2CASP1, CASP3
30complement deficiency10.2C3, MBL2, C5
31synovitis10.2TNFRSF1B, IL6
32connective tissue disease10.2C3, IL6
33tuberculosis10.1MBL2, TNFRSF1B, C3
34fibrosarcoma10.1TNFRSF1B, MMP9, HSPA1A
35pulmonary tuberculosis10.1MBL2, C3, CAT
36west nile virus10.1
37c3 deficiency10.1
38alcohol abuse10.1
39hepatitis10.1
40sinusitis10.1
41hepatitis c10.1
42acquired immunodeficiency syndrome10.1
43nasopharyngitis10.1
44pyomyositis10.1
45chickenpox10.1
46locked-in syndrome10.1
47cauda equina syndrome10.1
48streptococcal meningitis10.1
49hemolytic-uremic syndrome10.1
50epidural abscess10.1

Graphical network of the top 20 diseases related to Pneumococcal Meningitis:



Diseases related to pneumococcal meningitis

Symptoms for Pneumococcal Meningitis

About this section

Drugs & Therapeutics for Pneumococcal Meningitis

About this section

Drug clinical trials:

Search ClinicalTrials for Pneumococcal Meningitis

Search NIH Clinical Center for Pneumococcal Meningitis

Genetic Tests for Pneumococcal Meningitis

About this section

Anatomical Context for Pneumococcal Meningitis

About this section

MalaCards organs/tissues related to Pneumococcal Meningitis:

31
Brain, Testes, Cortex, Endothelial, Neutrophil, Bone, Spleen, Spinal cord, Myeloid

Animal Models for Pneumococcal Meningitis or affiliated genes

About this section

Publications for Pneumococcal Meningitis

About this section

Articles related to Pneumococcal Meningitis:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
Intrathecal application of the antimicrobial peptide CRAMP reduced mortality and neuroinflammation in an experimental model of pneumococcal meningitis. (25896094)
2015
2
Pneumococcal meningitis-associated pyogenic ventriculitis. (25452044)
2015
3
Chickenpox complicated by pneumococcal meningitis: A rare coinfection. (25282451)
2014
4
Vitamin B6 prevents cognitive impairment in experimental pneumococcal meningitis. (24903161)
2014
5
Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis. (24248324)
2013
6
Death is associated with complement C3 depletion in cerebrospinal fluid of patients with pneumococcal meningitis. (22415003)
2012
7
Brain abscesses complicating acute pneumococcal meningitis during etanercept therapy. (22634540)
2012
8
Cerebral ischaemia in the context of improving, steroid-treated pneumococcal meningitis. (21493690)
2012
9
Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis. (21261959)
2011
10
Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. (20875857)
2011
11
Treatment of Drug-resistant Pneumococcal Meningitis. (21308542)
2010
12
Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis? (20625175)
2010
13
High cerebrospinal fluid (CSF) penetration and potent bactericidal activity in CSF of NZ2114, a novel plectasin variant, during experimental pneumococcal meningitis. (19188395)
2009
14
Effect of the NMDA-receptor antagonist dextromethorphan in infant rat pneumococcal meningitis. (18220575)
2008
15
Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. (18625913)
2008
16
Late-onset rhabdomyolysis in pneumococcal meningitis: a case report. (17909699)
2007
17
Threshold shift: effects of cochlear implantation on the risk of pneumococcal meningitis. (17418257)
2007
18
Pneumococcal meningitis in community is frequent after craniocerebral trauma and in alcohol abusers. (18030267)
2007
19
Pneumococcal meningitis epidemics in Africa. (16912942)
2006
20
Clinical data and factors associated with poor outcome in pneumococcal meningitis. (16333641)
2006
21
Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury. (16956766)
2006
22
Gene expression in cortex and hippocampus during acute pneumococcal meningitis. (16749930)
2006
23
Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study. (16915106)
2006
24
C-reactive protein: a valuable acute investigation. A case of pneumococcal meningitis presenting as ankle pain. (16046777)
2005
25
Cerebral output of cytokines in patients with pneumococcal meningitis. (16276227)
2005
26
Penicillin-resistant pneumococcal meningitis: high antibiotic exposure impedes new vaccine protection. (15962556)
2005
27
Elevated cytokines in pneumococcal meningitis: Chicken or egg? (15891358)
2005
28
Austrian syndrome in a child-aortic valve endocarditis following pneumococcal meningitis. (15094001)
2004
29
Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice. (11891827)
2002
30
Recurrence of pneumococcal meningitis due to primary spontaneous cerebrospinal fluid fistulas. (11820653)
2001
31
Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus. (10696140)
2000
32
Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis. (10479144)
1999
33
Endothelin B receptor-mediated increase of cerebral blood flow in experimental pneumococcal meningitis. (9428307)
1998
34
A possible secondary case of pneumococcal meningitis. (9892535)
1998
35
Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis. (9083551)
1997
36
Ultrastructural damage to the organ of corti during acute experimental Escherichia coli and pneumococcal meningitis in guinea pigs. (8790739)
1996
37
Pneumococcal meningitis in children: prognostic indicators and outcome. (8749621)
1995
38
Drug-resistant pneumococcal meningitis in an American adult. (7548521)
1995
39
Fatal pneumococcal meningitis in an HIV-infected drug user despite previous pneumococcal immunization. (8061097)
1994
40
Methylprednisolone attenuates inflammation, increase of brain water content and intracranial pressure, but does not influence cerebral blood flow changes in experimental pneumococcal meningitis. (8032946)
1994
41
A review of the clinical presentation, laboratory features, antimicrobial therapy and outcome of 77 episodes of pneumococcal meningitis occurring in children and adults. (7806880)
1994
42
Is nitric oxide involved as a mediator of cerebrovascular changes in the early phase of experimental pneumococcal meningitis? (7913993)
1994
43
Evaluation of antimicrobial regimens for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. (8215275)
1993
44
Mortality in pneumococcal meningitis: a multivariate analysis of prognostic factors. (8258002)
1993
45
Antibiotic resistance to pneumococcal meningitis. (1353601)
1992
46
Autosplenectomy complicating pneumococcal meningitis in adults. (1627041)
1992
47
Sequential bacteriological findings in the cerebrospinal fluid of Nigerian patients with pneumococcal meningitis. (3958504)
1986
48
Pneumococcal meningitis with purpura. (4055694)
1985
49
Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis. (6517548)
1984
50
Cerebral arteritis and phlebitis in pneumococcal meningitis. (20297306)
1946

Variations for Pneumococcal Meningitis

About this section

Expression for genes affiliated with Pneumococcal Meningitis

About this section
Search GEO for disease gene expression data for Pneumococcal Meningitis.

Pathways for genes affiliated with Pneumococcal Meningitis

About this section

Pathways related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SRC, MMP9
2
Show member pathways
Angiogenesis36
9.7SRC, MMP9
39.7CASP1, CASP3
49.7CASP3, TNFRSF1B
59.5IL6, MMP9
69.5SRC, CASP3
7
Show member pathways
9.4CASP1, CASP3, IRAK4
89.4MMP9, TNFRSF1B, SRC
9
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.4CASP1, CASP3, TNFRSF1B
109.4CASP1, TNFRSF1B, CASP3
119.3IL6, CASP3
12
Show member pathways
9.3CASP1, IL6, IRAK4
13
Show member pathways
9.3IL6, IRAK4, TNFRSF1B
14
Show member pathways
Cytoskeleton remodeling FAK signaling59
Development Endothelin 1 EDNRA transactivation of EGFR59
9.3HSPA1A, SRC, MMP9
15
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
9.3CASP3, IRAK4, SRC
16
Show member pathways
thioredoxin pathway36
9.2CAT, KMO, IL6
179.2CASP1, SRC, CASP3
18
Show member pathways
Alternative NF-kappaB pathway36
9.2CASP3, TNFRSF1B, SRC
199.2SRC, C3, CASP3
209.2C5, IL6, HSPA1A
219.2MMP9, CASP3, SRC
22
Show member pathways
9.1IL6, SRC, CASP1
239.1C5, MBL2, C3
24
Show member pathways
Immune response Alternative complement pathway59
Immune response Lectin Induced complement pathway59
Immune response Classic complement pathway59
9.1C5, MBL2, C3
25
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.1C5, C3, MBL2
269.1IL6, SRC, MMP9
27
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
9.0TNFRSF1B, CASP3, CASP1, CAT
289.0IL6, MMP9, CASP3
29
Show member pathways
9.0CASP3, CASP1, SRC, IRAK4
30
Show member pathways
8.9CASP3, SRC, TNFRSF1B, CASP1
318.9CASP3, IRAK4, SRC, MMP9
32
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.9IRAK4, IL6, CASP1, SRC
33
Show member pathways
8.7HSPA1A, CASP3, CASP1, TNFRSF1B, IRAK4
348.7MMP9, IL6, TNFRSF1B, CASP3
35
Show member pathways
8.6TNFRSF1B, HSPA1A, IL6, CASP3
36
Show member pathways
8.6C3, C5, MBL2, SRC
378.5MMP9, SRC, IL6, CASP3
388.5MMP9, IL6, CASP3, SRC
39
Show member pathways
8.4HSPA1A, IRAK4, IL6, C3, CASP3
40
Show member pathways
8.3TNFRSF1B, IRAK4, SRC, IL6, CASP3
41
Show member pathways
8.3IL6, SRC, CASP3, TNFRSF1B, IRAK4
428.3CASP3, HSPA1A, IL6, C3, CASP1
438.3SRC, IL6, IRAK4, CASP3, C3
44
Show member pathways
8.3CASP1, TNFRSF1B, SRC, IL6, CASP3
458.2C3, IRAK4, IL6, C5, CASP1, CASP3
46
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.0CASP1, TNFRSF1B, CASP3, HSPA1A, MMP9, IL6
47
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.0IL6, C3, SRC, CASP3, MMP9, IRAK4
48
Show member pathways
7.9CASP3, CASP1, TNFRSF1B, MMP9, SRC, IL6
49
Show member pathways
7.9CASP1, IL6, SRC, HSPA1A, TNFRSF1B, CASP3
50
Show member pathways
7.8CASP3, HSPA1A, C5, IL6, CASP1, C3

Compounds for genes affiliated with Pneumococcal Meningitis

About this section

Compounds related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1minocycline44 1110.7CASP1, MMP9, CASP3
2trolox449.7CASP1, CASP3, CAT
3staurosporin449.6SRC, CASP1, CASP3
4dutp449.5CASP1, CASP3, TNFRSF1B
5anaphylatoxin449.5C3, IL6, C5
6s-nitroso-n-acetylpenicillamine449.5CAT, CASP1, CASP3
7helenalin449.4SRC, MMP9, IL6
8alpha lipoic acid449.4MMP9, HSPA1A, CAT
9tpck449.4CASP1, IL6, CASP3
10parthenolide44 110.3CASP3, IL6, MMP9
11diphenyleneiodonium449.2CASP3, CASP1, CAT, SRC
12ciglitazone44 2810.2MMP9, IL6, CASP3
13quercetin44 60 24 1112.2HSPA1A, CASP3, CAT, CASP1
14rotenone449.2CASP3, CASP1, CAT
15endotoxin449.2HSPA1A, TNFRSF1B, IL6, CASP1
168-isoprostane449.1CAT, HSPA1A, MMP9, IL6
17pdtc449.0CAT, IL6, CASP3, MMP9
18zoledronic acid449.0CASP3, MMP9, IL6, SRC
195fluorouracil448.9CASP1, CASP3, SRC, TNFRSF1B
20neopterin448.8TNFRSF1B, MBL2, C3, IL6
21pge2448.8TNFRSF1B, SRC, IL6, MMP9, CASP1
22peptidoglycan44 289.7IL6, CASP1, MBL2
23cisplatin44 50 60 1111.7CASP1, CASP3, SRC, HSPA1A, TNFRSF1B
24norepinephrine44 24 1110.7TNFRSF1B, HSPA1A, MMP9, SRC, IL6
25ly294002448.6TNFRSF1B, MMP9, SRC, IL6, CASP3
26arsenite44 249.5HSPA1A, CAT, CASP1, CASP3, MMP9, SRC
27h2o2448.5TNFRSF1B, CAT, CASP1, CASP3, SRC, HSPA1A
28fibrinogen448.4IL6, C3, TNFRSF1B, MBL2, MMP9
29aspartate448.4MBL2, CASP1, MMP9, HSPA1A, SRC
30curcumin448.3IL6, MMP9, CAT, CASP3, SRC, TNFRSF1B
31pd 98,059448.3CASP1, HSPA1A, SRC, IL6, CASP3, MMP9
32superoxide44 249.2HSPA1A, MBL2, TNFRSF1B, CASP3, CASP1, CAT
33rantes448.1MBL2, IL6, MMP9, TNFRSF1B
34creatinine448.1HSPA1A, MBL2, CASP1, C3, IL6, MMP9
35actinomycin d448.1TNFRSF1B, CAT, CASP1, HSPA1A, CASP3, IL6
36cycloheximide448.0CAT, CASP1, CASP3, IL6, MMP9, HSPA1A
37lactate448.0CASP1, CASP3, IL6, C3, CAT, MMP9
38nitric oxide44 24 1110.0CAT, IL6, HSPA1A, TNFRSF1B, CASP1, MBL2
39cyclosporin a44 28 6010.0TNFRSF1B, IL6, MMP9, CASP3, SRC, CASP1
40n acetylcysteine447.9SRC, MMP9, IL6, CASP3, CASP1, CAT
41sb 20358044 608.9CASP1, CASP3, IL6, SRC, CAT, MMP9
42glucose447.9HSPA1A, IL6, TNFRSF1B, C3, CASP1, MBL2
43lipid447.7IL6, C3, CASP1, CAT, MBL2, TNFRSF1B
44serine447.6IRAK4, MMP9, TNFRSF1B, CASP1, CASP3, C3
45vegf447.5TNFRSF1B, MMP9, MBL2, SRC, CASP3, CASP1
46cysteine447.5SRC, MMP9, MBL2, CAT, TNFRSF1B, CASP1
47oxygen44 248.4MBL2, IRAK4, CAT, TNFRSF1B, HSPA1A, KMO
48dexamethasone44 50 28 1110.4MMP9, C3, IL6, SRC, HSPA1A, TNFRSF1B
49tyrosine447.3CASP1, TNFRSF1B, HSPA1A, MMP9, MBL2, IL6
50estrogen447.3HSPA1A, MMP9, SRC, TNFRSF1B, C3, CASP1

GO Terms for genes affiliated with Pneumococcal Meningitis

About this section

Cellular components related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1MBL2, C5, C3, IL6, MMP9
2extracellular regionGO:00055766.7MBL2, TNFRSF1B, MMP9, LGALS9, IL6, C3

Biological processes related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:000695710.1C5, C3
2positive regulation vascular endothelial growth factor productionGO:001057510.0C5, C3
3regulation of complement activationGO:003044910.0C5, C3
4execution phase of apoptosisGO:00971949.6CASP1, CASP3
5positive regulation of phagocytosisGO:00507669.4MBL2, C3
6proteolysisGO:00065089.3MMP9, CASP3, CASP1
7complement activationGO:00069569.3MBL2, C5, C3
8complement activation, classical pathwayGO:00069589.3C3, C5, MBL2
9inflammatory responseGO:00069549.2C5, C3, IL6, TNFRSF1B
10acute-phase responseGO:00069539.0MBL2, IL6
11defense response to Gram-positive bacteriumGO:00508308.7MBL2, IL6
12negative regulation of apoptotic processGO:00430668.7SRC, IL6, CASP3, CAT
13innate immune responseGO:00450878.4MBL2, IRAK4, SRC, C3, CASP1, C5

Molecular functions related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00048669.9C5, C3
2receptor bindingGO:00051028.1MBL2, C5, CAT, C3, SRC
3protein bindingGO:00055156.0SRC, IRAK4, MMP9, TNFRSF1B, IL6, C3

Sources for Pneumococcal Meningitis

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet