MCID: PNM013
MIFTS: 47

Pneumococcal Meningitis malady

Neuronal, Infectious categories

Summaries for Pneumococcal Meningitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Pneumococcal infection refers to an infection caused by Streptococcus pneumoniae. more...

MalaCards: Pneumococcal Meningitis, also known as meningitis, pneumococcal, is related to brain edema and vasculitis. An important gene associated with Pneumococcal Meningitis is IRAK4 (interleukin-1 receptor-associated kinase 4), and among its related pathways are Activation of C3 and C5 and Terminal pathway of complement. The compounds estrogen and anaphylatoxin have been mentioned in the context of this disorder. Affiliated tissues include spleen, brain and cortex, and related mouse phenotypes are renal/urinary system and vision/eye.

Aliases & Classifications for Pneumococcal Meningitis

Sources:
49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Neuronal


Aliases & Descriptions:

pneumococcal meningitis 49
meningitis, pneumococcal 61


External Ids:

MESH via Orphanet36 D008586
ICD10 via Orphanet26 G00.1
SNOMED-CT via Orphanet58 51169003
UMLS via Orphanet62 C0025295
ICD1025 G00.1

Related Diseases for Pneumococcal Meningitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Pneumococcal Meningitis:



Diseases related to pneumococcal meningitis

Clinical Features for Pneumococcal Meningitis

Drugs & Therapeutics for Pneumococcal Meningitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pneumococcal Meningitis

Drug clinical trials:

Search ClinicalTrials for Pneumococcal Meningitis

Search NIH Clinical Center for Pneumococcal Meningitis

Search CenterWatch for Pneumococcal Meningitis

Genetic Tests for Pneumococcal Meningitis

Anatomical Context for Pneumococcal Meningitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Pneumococcal Meningitis:

33
Spleen, Brain, Cortex, Spinal cord, Myeloid, B cells, Endothelial

Animal Models for Pneumococcal Meningitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pneumococcal Meningitis

Sources:
51PubMed
See all sources

Articles related to Pneumococcal Meningitis:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Inhibition of matrix metalloproteinases-2 and -9 prevents cognitive impairment induced by pneumococcal meningitis in Wistar rats. (24419461)
2014
2
Streptococcus pneumoniae Arginine Synthesis Genes Promote Growth and Virulence in Pneumococcal Meningitis. (24338350)
2014
3
Pneumococcal meningitis in children: epidemiology, serotypes, and outcomes from 1997-2010 in Utah. (23979090)
2013
4
Effects of B7-H3 on the inflammatory response and expression of MMP-9 in mice with pneumococcal meningitis. (23054584)
2013
5
Adult pneumococcal meningitis presenting with normocellular cerebrospinal fluid: two case reports. (24378083)
2013
6
Mortality indicators in pneumococcal meningitis: therapeutic implications. (24211227)
2013
7
Imipramine reverses depressive-like parameters in pneumococcal meningitis survivor rats. (22160551)
2012
8
Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis. (21261959)
2011
9
Pneumocephalus and pneumococcal meningitis secondary to a cerebrospinal fluid fistula. (21397993)
2011
10
S100B in the cerebrospinal fluid--a marker for glial damage in the rabbit model of pneumococcal meningitis. (20347934)
2010
11
Experimental studies of pneumococcal meningitis. (20175949)
2010
12
Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis. (19478887)
2009
13
Experimental study of meropenem in the therapy of cephalosporin-susceptible and -resistant pneumococcal meningitis. (18386085)
2008
14
Can we prevent cochlear implant recipients from developing pneumococcal meningitis? (18171202)
2008
15
Clinical data and factors associated with poor outcome in pneumococcal meningitis. (16333641)
2006
16
Quadriparesis from a panspinal extradural abscess following pneumococcal meningitis. (17152434)
2006
17
Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series. (16426988)
2006
18
Dexamethasone treatment in adults with pneumococcal meningitis: risk factors for death. (16470361)
2006
19
Combined treatment with ceftriaxone and linezolid of pneumococcal meningitis: a case series including penicillin-resistant strains. (16524418)
2006
20
Long-term beneficial effects of dexamethasone on intellectual and neuropsychological outcome of children with pneumococcal meningitis. (16449000)
2006
21
Elevated cytokines in pneumococcal meningitis: Chicken or egg? (15891358)
2005
22
Cerebral output of cytokines in patients with pneumococcal meningitis. (15891324)
2005
23
Blocking of leukocyte accumulation in the cerebrospinal fluid augments bacteremia and increases lethality in experimental pneumococcal meningitis. (15982752)
2005
24
Neuroprotective effects of brain-derived neurotrophic factor (BDNF) on hearing in experimental pneumococcal meningitis. (15791923)
2005
25
Dexamethasone and pneumococcal meningitis. (15313761)
2004
26
Method for inducing experimental pneumococcal meningitis in outbred mice. (15385055)
2004
27
Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis. (12654856)
2003
28
Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice. (11891827)
2002
29
Pathogenesis and pathophysiology of pneumococcal meningitis. (12467688)
2002
30
Experimental study of the efficacy of vancomycin, rifampicin and dexamethasone in the therapy of pneumococcal meningitis. (11864951)
2002
31
Reactive nitrogen species contribute to blood-labyrinth barrier disruption in suppurative labyrinthitis complicating experimental pneumococcal meningitis in the rat. (11406118)
2001
32
Effects of clinically used antioxidants in experimental pneumococcal meningitis. (10882622)
2000
33
Treatment with a monocolonal antibody to IL-8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally. (11091276)
2000
34
Comparative therapeutic efficacy of clinafloxacin in a pneumococcal meningitis mouse model. (10747826)
2000
35
Pneumococcal meningitis: current pathophysiologic concepts. (10647088)
1999
36
Effects of nimodipine on the cerebrovascular and neuronal changes during pneumococcal meningitis in the rat. (9468731)
1997
37
Elimination of blood-derived macrophages inhibits the release of interleukin-1 and the entry of leukocytes into the cerebrospinal fluid in experimental pneumococcal meningitis. (9058762)
1997
38
Ultrastructural damage to the organ of corti during acute experimental Escherichia coli and pneumococcal meningitis in guinea pigs. (8790739)
1996
39
Cerebrospinal fluid filtration in a case of severe pneumococcal meningitis. (8953673)
1996
40
A case of penicillin-resistant pneumococcal meningitis. (8867231)
1996
41
Case report: penicillin-resistant pneumococcal meningitis: navigating a therapeutic minefield. (8602648)
1996
42
Slow recovery of cerebrospinal fluid glucose and protein concentrations distinguish pneumococcal from Haemophilus influenzae and meningococcal meningitis in children. (8584322)
1995
43
The impact of dexamethasone on hearing loss in experimental pneumococcal meningitis. (7746714)
1995
44
Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide. (7535035)
1995
45
A review of the clinical presentation, laboratory features, antimicrobial therapy and outcome of 77 episodes of pneumococcal meningitis occurring in children and adults. (7806880)
1994
46
The pathophysiology of pneumococcal meningitis. (7695866)
1994
47
Acute endocarditis following pneumococcal meningitis. (8482282)
1993
48
Superoxide dismutase inhibits brain oedema formation in experimental pneumococcal meningitis. (2089945)
1990
49
Relatively penicillin-resistant pneumococcal meningitis in a Brazilian infant. (3393404)
1988
50
Successful Chemotherapy for Haemolytic Streptococcal Meningitis and Pneumococcal Meningitis in the Same Patient. (20783102)
1940

Genetic Variations for Pneumococcal Meningitis

Expression for genes affiliated with Pneumococcal Meningitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pneumococcal Meningitis

Search GEO for disease gene expression data for Pneumococcal Meningitis.

Pathways for genes affiliated with Pneumococcal Meningitis

Sources:
54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology, 56SinoBiological, 53R&D Systems, 12EMD Millipore
See all sources

Pathways related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9C3, C5
2
Hide members
9.9C5, C3
3
Mucin expression in CF via IL-6, IL-17 signaling pathways
9.8SRC, IRAK4
4
Hide members
9.7TNFRSF1B, SRC
59.7MMP9, SRC
6
Hide members
9.4C3, C5, SRC
7
Hide members
9.4C3, IRAK4, HSPA1A
89.3SRC, TNFRSF1B, MMP9
9
Hide members
9.3CASP3, IRAK4, CASP1
10
Hide members
9.2TNFRSF1B, CASP3, CASP1
11
Hide members
9.2TNFRSF1B, CASP3, CASP1
129.2CASP1, CASP3, TNFRSF1B
139.2SRC, CASP3, CASP1
14
Hide members
9.1IRAK4, IL6, CASP1
15
Hide members
9.0CASP3, CASP1, TNFRSF1B, IRAK4
168.9CAT, KMO, IL6
178.9IL6, MMP9, SRC
188.8HSPA1A, C5, IL6
198.8MMP9, SRC, IRAK4, CASP3
20
Hide members
8.8TNFRSF1B, CAT, CASP1, CASP3
21
Hide members
8.7IRAK4, CASP1, SRC, IL6
228.7CASP3, IL6, MMP9
23
Hide members
8.5IRAK4, TNFRSF1B, CASP3, CASP1, HSPA1A
248.3CASP3, TNFRSF1B, IL6, MMP9
258.2IL6, SRC, MMP9, CASP3
268.2MMP9, SRC, IL6, CASP3
27
Hide members
8.2IL6, CASP3, HSPA1A, TNFRSF1B
288.0IRAK4, IL6, SRC, CASP3, C3
29
Hide members
8.0TNFRSF1B, IRAK4, IL6, SRC, CASP3
307.9IL6, CASP3, CASP1, HSPA1A, C3
317.9CASP1, IRAK4, IL6, C3, C5, CASP3
32
Hide members
7.7MMP9, C3, IL6, SRC, CASP3, IRAK4
33
Hide members
7.6MMP9, IL6, TNFRSF1B, CASP3, CASP1, SRC
34
Hide members
7.5MMP9, IL6, TNFRSF1B, HSPA1A, CASP1, CASP3
35
Hide members
7.5CASP3, SRC, IL6, TNFRSF1B, CASP1, HSPA1A
36
Hide members
7.4IL6, IRAK4, CASP3, CASP1, HSPA1A, C3

Compounds for genes affiliated with Pneumococcal Meningitis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1estrogen4510.5TNFRSF1B
2anaphylatoxin4510.5C5
3cycloheximide4510.5CAT
4rotenone4510.4CASP1
5endotoxin4510.2CASP1, TNFRSF1B
6pge24510.0SRC, MMP9
7norepinephrine45 11 2411.9HSPA1A, SRC
8cyclosporin a45 29 6011.9SRC, TNFRSF1B, CASP1
9evodiamine459.7CASP1, CASP3
10minocycline45 1110.6CASP1, MMP9, CASP3
11diphenyleneiodonium459.6CASP1, SRC, CASP3
12staurosporin459.5CASP1, SRC, CASP3
13superoxide45 2410.5CASP3, TNFRSF1B, CASP1
14dutp459.5CASP3, CASP1, TNFRSF1B
15nmda45 2910.5CASP1, SRC, KMO
16trolox459.5CASP1, CAT, CASP3
17zoledronic acid459.5CASP3, MMP9, SRC
18s-nitroso-n-acetylpenicillamine459.4CAT, CASP1, CASP3
19alpha lipoic acid459.4CAT, MMP9, HSPA1A
20helenalin459.3IL6, MMP9, SRC
21manganese superoxide459.3TNFRSF1B, CAT, HSPA1A
22creatinine459.3CASP1, MMP9, C3, HSPA1A
23fluvastatin45 50 29 1112.2CASP1, MMP9, IL6
24salicylic acid45 2910.2CAT, HSPA1A, SRC
25ivig459.1MMP9, IL6, TNFRSF1B
26tpck459.1CASP1, IL6, CASP3
275fluorouracil459.0CASP3, CASP1, TNFRSF1B, SRC
28parthenolide45 210.0IL6, MMP9, CASP3
29ciglitazone45 2910.0IL6, MMP9, CASP3
30neopterin459.0TNFRSF1B, C3, IL6
31serine459.0SRC, TNFRSF1B, C3, MMP9, CASP1
32quercetin45 60 11 2412.0CASP1, CASP3, CAT, HSPA1A
33oxygen45 249.9TNFRSF1B, HSPA1A, CASP1, IRAK4, KMO, C3
34h2o2458.9HSPA1A, CASP1, CAT, TNFRSF1B, SRC
358-isoprostane458.7HSPA1A, CAT, IL6, MMP9
36arsenite45 249.7CASP3, SRC, MMP9, CASP1, HSPA1A
37pdtc458.6CAT, IL6, MMP9, CASP3
38cisplatin45 50 60 1111.6HSPA1A, SRC, TNFRSF1B, CASP3, CASP1
3915-deoxy-delta-12,14-prostaglandin j2458.4CASP3, IL6, HSPA1A
40ly294002458.3CASP3, SRC, MMP9, IL6, TNFRSF1B
41dexamethasone45 50 29 1111.2CASP1, IL6, TNFRSF1B, HSPA1A, MMP9, C3
42cysteine458.1CASP1, CASP3, CAT, TNFRSF1B, MMP9, SRC
43vegf458.0SRC, TNFRSF1B, CASP1, MMP9, IL6, CASP3
44testosterone45 60 11 2410.9CASP1, TNFRSF1B, IL6, MMP9, SRC
45curcumin457.9SRC, MMP9, TNFRSF1B, IL6, CASP3, CAT
46pd 98,059457.9HSPA1A, CASP3, IL6, MMP9, SRC, CASP1
47lactate457.5IL6, MMP9, CASP3, CASP1, HSPA1A, C3
48actinomycin d457.5TNFRSF1B, HSPA1A, CASP1, CASP3, CAT, MMP9
49n acetylcysteine457.4SRC, IL6, MMP9, CAT, CASP3, CASP1
50sb 20358045 608.4MMP9, HSPA1A, CASP1, CASP3, CAT, IL6

GO Terms for genes affiliated with Pneumococcal Meningitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5C3, C5, LGALS9, MMP9, IL6, TNFRSF1B

Biological processes related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation vascular endothelial growth factor productionGO:0105759.9C5, C3
2complement activation, alternative pathwayGO:0069579.6C5, C3
3innate immune responseGO:0450878.9CASP1, IRAK4, SRC, C5, C3
4inflammatory responseGO:0069548.6C3, TNFRSF1B, IL6, C5

Molecular functions related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.0C3, C5, SRC, CAT

Products for genes affiliated with Pneumococcal Meningitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pneumococcal Meningitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet