MCID: PNM013
MIFTS: 55

Pneumococcal Meningitis malady

Neuronal diseases, Infectious diseases, Rare diseases categories

Summaries for Pneumococcal Meningitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Pneumococcal infection refers to an infection caused by Streptococcus pneumoniae. more...

MalaCards: Pneumococcal Meningitis, also known as meningitis, pneumococcal, is related to meningitis and pneumonia. An important gene associated with Pneumococcal Meningitis is IRAK4 (interleukin-1 receptor-associated kinase 4), and among its related pathways are Plasma membrane estrogen receptor signaling and Angiogenesis. The compounds minocycline and trolox have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are muscle and tumorigenesis.

Aliases & Classifications for Pneumococcal Meningitis

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50Orphanet, 63UMLS, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

pneumococcal meningitis 50
meningitis, pneumococcal 63


External Ids:

MESH via Orphanet37 D008586
ICD10 via Orphanet27 G00.1
SNOMED-CT via Orphanet60 51169003
UMLS via Orphanet64 C0025295
ICD1026 G00.1

Related Diseases for Pneumococcal Meningitis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Pneumococcal Meningitis:



Diseases related to pneumococcal meningitis

Symptoms for Pneumococcal Meningitis

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Drugs & Therapeutics for Pneumococcal Meningitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Pneumococcal Meningitis

Drug clinical trials:

Search ClinicalTrials for Pneumococcal Meningitis

Search NIH Clinical Center for Pneumococcal Meningitis

Search CenterWatch for Pneumococcal Meningitis

Genetic Tests for Pneumococcal Meningitis

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Anatomical Context for Pneumococcal Meningitis

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34MalaCards
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MalaCards organs/tissues related to Pneumococcal Meningitis:

34
Brain, Testes, Cortex, Endothelial, Bone, Spleen, Spinal cord, Myeloid

Animal Models for Pneumococcal Meningitis or affiliated genes

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38MGI
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Publications for Pneumococcal Meningitis

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53PubMed
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Articles related to Pneumococcal Meningitis:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis. (24248324)
2013
2
Death is associated with complement C3 depletion in cerebrospinal fluid of patients with pneumococcal meningitis. (22415003)
2012
3
Brain abscesses complicating acute pneumococcal meningitis during etanercept therapy. (22634540)
2012
4
Cerebral ischaemia in the context of improving, steroid-treated pneumococcal meningitis. (21493690)
2012
5
Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis. (21261959)
2011
6
Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. (20875857)
2011
7
The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release. (22003197)
2011
8
Treatment of Drug-resistant Pneumococcal Meningitis. (21308542)
2010
9
Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis? (20625175)
2010
10
High cerebrospinal fluid (CSF) penetration and potent bactericidal activity in CSF of NZ2114, a novel plectasin variant, during experimental pneumococcal meningitis. (19188395)
2009
11
Effect of pneumococcal conjugate vaccine on pneumococcal meningitis. (19144940)
2009
12
Effect of the NMDA-receptor antagonist dextromethorphan in infant rat pneumococcal meningitis. (18220575)
2008
13
Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. (18625913)
2008
14
Changing epidemiology of pneumococcal meningitis after the introduction of pneumococcal conjugate vaccine in the United States. (18433334)
2008
15
Late-onset rhabdomyolysis in pneumococcal meningitis: a case report. (17909699)
2007
16
Threshold shift: effects of cochlear implantation on the risk of pneumococcal meningitis. (17418257)
2007
17
Pneumococcal meningitis in community is frequent after craniocerebral trauma and in alcohol abusers. (18030267)
2007
18
Pneumococcal meningitis epidemics in Africa. (16912942)
2006
19
Clinical data and factors associated with poor outcome in pneumococcal meningitis. (16333641)
2006
20
Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury. (16956766)
2006
21
Gene expression in cortex and hippocampus during acute pneumococcal meningitis. (16749930)
2006
22
Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study. (16915106)
2006
23
C-reactive protein: a valuable acute investigation. A case of pneumococcal meningitis presenting as ankle pain. (16046777)
2005
24
Cerebral output of cytokines in patients with pneumococcal meningitis. (16276227)
2005
25
Penicillin-resistant pneumococcal meningitis: high antibiotic exposure impedes new vaccine protection. (15962556)
2005
26
Elevated cytokines in pneumococcal meningitis: Chicken or egg? (15891358)
2005
27
Reduction of astrogliosis by early treatment of pneumococcal meningitis measured by simultaneous imaging, in vivo, of the pathogen and host response. (16299273)
2005
28
Austrian syndrome in a child-aortic valve endocarditis following pneumococcal meningitis. (15094001)
2004
29
Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice. (11891827)
2002
30
Recurrence of pneumococcal meningitis due to primary spontaneous cerebrospinal fluid fistulas. (11820653)
2001
31
Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus. (10696140)
2000
32
Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis. (10479144)
1999
33
Endothelin B receptor-mediated increase of cerebral blood flow in experimental pneumococcal meningitis. (9428307)
1998
34
A possible secondary case of pneumococcal meningitis. (9892535)
1998
35
Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis. (9083551)
1997
36
Ultrastructural damage to the organ of corti during acute experimental Escherichia coli and pneumococcal meningitis in guinea pigs. (8790739)
1996
37
Pneumococcal meningitis in children: prognostic indicators and outcome. (8749621)
1995
38
Drug-resistant pneumococcal meningitis in an American adult. (7548521)
1995
39
Fatal pneumococcal meningitis in an HIV-infected drug user despite previous pneumococcal immunization. (8061097)
1994
40
Methylprednisolone attenuates inflammation, increase of brain water content and intracranial pressure, but does not influence cerebral blood flow changes in experimental pneumococcal meningitis. (8032946)
1994
41
A review of the clinical presentation, laboratory features, antimicrobial therapy and outcome of 77 episodes of pneumococcal meningitis occurring in children and adults. (7806880)
1994
42
Is nitric oxide involved as a mediator of cerebrovascular changes in the early phase of experimental pneumococcal meningitis? (7913993)
1994
43
Evaluation of antimicrobial regimens for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. (8215275)
1993
44
Mortality in pneumococcal meningitis: a multivariate analysis of prognostic factors. (8258002)
1993
45
Antibiotic resistance to pneumococcal meningitis. (1353601)
1992
46
Autosplenectomy complicating pneumococcal meningitis in adults. (1627041)
1992
47
Sequential bacteriological findings in the cerebrospinal fluid of Nigerian patients with pneumococcal meningitis. (3958504)
1986
48
Pneumococcal meningitis with purpura. (4055694)
1985
49
Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis. (6517548)
1984
50
Cerebral arteritis and phlebitis in pneumococcal meningitis. (20297306)
1946

Variations for Pneumococcal Meningitis

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Expression for genes affiliated with Pneumococcal Meningitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pneumococcal Meningitis

Search GEO for disease gene expression data for Pneumococcal Meningitis.

Pathways for genes affiliated with Pneumococcal Meningitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 5Cell Signaling Technology, 61Thomson Reuters, 54QIAGEN, 56Reactome, 31KEGG, 58SinoBiological, 55R&D Systems
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Pathways related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MMP9, SRC
2
Show member pathways
Angiogenesis39
9.7SRC, MMP9
39.7CASP3, CASP1
49.7TNFRSF1B, CASP3
59.5IL6, MMP9
69.5SRC, CASP3
7
Show member pathways
9.4CASP1, CASP3, IRAK4
89.4SRC, MMP9, TNFRSF1B
9
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.4TNFRSF1B, CASP3, CASP1
109.4TNFRSF1B, CASP3, CASP1
119.3CASP3, IL6
12
Show member pathways
9.3CASP1, IL6, IRAK4
13
Show member pathways
9.3IL6, IRAK4, TNFRSF1B
14
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
9.3SRC, MMP9, HSPA1A
15
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.3CASP3, SRC, IRAK4
16
Show member pathways
thioredoxin pathway39
9.2KMO, IL6, CAT
179.2SRC, CASP3, CASP1
18
Show member pathways
Alternative NF-kappaB pathway39
9.2CASP3, SRC, TNFRSF1B
199.2SRC, C3, CASP3
209.2C5, IL6, HSPA1A
219.2CASP3, SRC, MMP9
22
Show member pathways
9.1SRC, IL6, CASP1
23
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.1MBL2, C5, C3
249.1MBL2, C5, C3
25
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.1C3, C5, MBL2
269.1MMP9, SRC, IL6
27
Show member pathways
Amyotrophic lateral sclerosis (ALS)39
9.0CAT, CASP1, CASP3, TNFRSF1B
289.0CASP3, IL6, MMP9
29
Show member pathways
9.0IRAK4, SRC, CASP3, CASP1
30
Show member pathways
8.9CASP1, CASP3, SRC, TNFRSF1B
318.9MMP9, IRAK4, SRC, CASP3
32
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.9IRAK4, SRC, IL6, CASP1
33
Show member pathways
8.7CASP1, CASP3, IRAK4, HSPA1A, TNFRSF1B
348.7TNFRSF1B, MMP9, IL6, CASP3
35
Show member pathways
8.6TNFRSF1B, HSPA1A, IL6, CASP3
36
Show member pathways
8.6MBL2, C5, C3, SRC
378.5MMP9, SRC, IL6, CASP3
388.5MMP9, SRC, IL6, CASP3
39
Show member pathways
8.4HSPA1A, IRAK4, IL6, C3, CASP3
40
Show member pathways
8.3TNFRSF1B, IRAK4, SRC, IL6, CASP3
41
Show member pathways
8.3TNFRSF1B, IRAK4, SRC, IL6, CASP3
428.3HSPA1A, IL6, C3, CASP3, CASP1
438.3IRAK4, SRC, IL6, C3, CASP3
44
Show member pathways
8.3TNFRSF1B, SRC, IL6, CASP3, CASP1
458.2C5, CASP1, CASP3, C3, IL6, IRAK4
46
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
8.0TNFRSF1B, HSPA1A, MMP9, IL6, CASP3, CASP1
47
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.0MMP9, IRAK4, SRC, IL6, C3, CASP3
48
Show member pathways
7.9TNFRSF1B, MMP9, SRC, IL6, CASP3, CASP1
49
Show member pathways
7.9TNFRSF1B, HSPA1A, SRC, IL6, CASP3, CASP1
50
Show member pathways
7.8HSPA1A, IRAK4, IL6, C3, CASP3, CASP1

Compounds for genes affiliated with Pneumococcal Meningitis

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Sources:
46Novoseek, 12DrugBank, 3BitterDB, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 52PharmGKB
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Compounds related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1minocycline46 1210.7CASP1, MMP9, CASP3
2trolox469.7CASP1, CASP3, CAT
3staurosporin469.6SRC, CASP1, CASP3
4dutp469.5CASP1, CASP3, TNFRSF1B
5anaphylatoxin469.5C3, IL6, C5
6s-nitroso-n-acetylpenicillamine469.5CAT, CASP1, CASP3
7helenalin469.4SRC, MMP9, IL6
8alpha lipoic acid469.4MMP9, HSPA1A, CAT
9tpck469.4CASP1, IL6, CASP3
10parthenolide46 310.3CASP3, IL6, MMP9
11diphenyleneiodonium469.2CASP3, CASP1, CAT, SRC
12ciglitazone46 3010.2MMP9, IL6, CASP3
13quercetin46 62 25 1212.2HSPA1A, CASP3, CAT, CASP1
14rotenone469.2CASP3, CASP1, CAT
15endotoxin469.2HSPA1A, TNFRSF1B, IL6, CASP1
168-isoprostane469.1CAT, HSPA1A, MMP9, IL6
17pdtc469.0CAT, IL6, CASP3, MMP9
18zoledronic acid469.0CASP3, MMP9, IL6, SRC
195fluorouracil468.9CASP1, CASP3, SRC, TNFRSF1B
20neopterin468.8TNFRSF1B, MBL2, C3, IL6
21pge2468.8TNFRSF1B, SRC, IL6, MMP9, CASP1
22peptidoglycan46 309.7IL6, CASP1, MBL2
23cisplatin46 52 62 1211.7CASP1, CASP3, SRC, HSPA1A, TNFRSF1B
24norepinephrine46 25 1210.7TNFRSF1B, HSPA1A, MMP9, SRC, IL6
25ly294002468.6TNFRSF1B, MMP9, SRC, IL6, CASP3
26arsenite46 259.5HSPA1A, CAT, CASP1, CASP3, MMP9, SRC
27h2o2468.5TNFRSF1B, CAT, CASP1, CASP3, SRC, HSPA1A
28fibrinogen468.4IL6, C3, TNFRSF1B, MBL2, MMP9
29aspartate468.4MBL2, CASP1, MMP9, HSPA1A, SRC
30curcumin468.3IL6, MMP9, CAT, CASP3, SRC, TNFRSF1B
31pd 98,059468.3CASP1, HSPA1A, SRC, IL6, CASP3, MMP9
32superoxide46 259.2HSPA1A, MBL2, TNFRSF1B, CASP3, CASP1, CAT
33rantes468.1MBL2, IL6, MMP9, TNFRSF1B
34creatinine468.1HSPA1A, MBL2, CASP1, C3, IL6, MMP9
35actinomycin d468.1TNFRSF1B, CAT, CASP1, HSPA1A, CASP3, IL6
36cycloheximide468.0CAT, CASP1, CASP3, IL6, MMP9, HSPA1A
37lactate468.0CASP1, CASP3, IL6, C3, CAT, MMP9
38nitric oxide46 25 1210.0CAT, IL6, HSPA1A, TNFRSF1B, CASP1, MBL2
39cyclosporin a46 30 6210.0TNFRSF1B, IL6, MMP9, CASP3, SRC, CASP1
40n acetylcysteine467.9SRC, MMP9, IL6, CASP3, CASP1, CAT
41sb 20358046 628.9CASP1, CASP3, IL6, SRC, CAT, MMP9
42glucose467.9HSPA1A, IL6, TNFRSF1B, C3, CASP1, MBL2
43lipid467.7IL6, C3, CASP1, CAT, MBL2, TNFRSF1B
44serine467.6IRAK4, MMP9, TNFRSF1B, CASP1, CASP3, C3
45vegf467.5TNFRSF1B, MMP9, MBL2, SRC, CASP3, CASP1
46cysteine467.5SRC, MMP9, MBL2, CAT, TNFRSF1B, CASP1
47oxygen46 258.4MBL2, IRAK4, CAT, TNFRSF1B, HSPA1A, KMO
48dexamethasone46 52 30 1210.4MMP9, C3, IL6, SRC, HSPA1A, TNFRSF1B
49tyrosine467.3CASP1, TNFRSF1B, HSPA1A, MMP9, MBL2, IL6
50estrogen467.3HSPA1A, MMP9, SRC, TNFRSF1B, C3, CASP1

GO Terms for genes affiliated with Pneumococcal Meningitis

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17Gene Ontology
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Cellular components related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1MBL2, C5, C3, IL6, MMP9
2extracellular regionGO:0055766.7MBL2, TNFRSF1B, MMP9, LGALS9, IL6, C3

Biological processes related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:00695710.1C5, C3
2positive regulation vascular endothelial growth factor productionGO:01057510.0C5, C3
3regulation of complement activationGO:03044910.0C5, C3
4execution phase of apoptosisGO:0971949.6CASP1, CASP3
5positive regulation of phagocytosisGO:0507669.4MBL2, C3
6proteolysisGO:0065089.3MMP9, CASP3, CASP1
7complement activationGO:0069569.3MBL2, C5, C3
8complement activation, classical pathwayGO:0069589.3C3, C5, MBL2
9inflammatory responseGO:0069549.2C5, C3, IL6, TNFRSF1B
10acute-phase responseGO:0069539.0MBL2, IL6
11defense response to Gram-positive bacteriumGO:0508308.7MBL2, IL6
12negative regulation of apoptotic processGO:0430668.7SRC, IL6, CASP3, CAT
13innate immune responseGO:0450878.4MBL2, IRAK4, SRC, C3, CASP1, C5

Molecular functions related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.9C5, C3
2receptor bindingGO:0051028.1MBL2, C5, CAT, C3, SRC
3protein bindingGO:0055156.0SRC, IRAK4, MMP9, TNFRSF1B, IL6, C3

Products for genes affiliated with Pneumococcal Meningitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pneumococcal Meningitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet