MCID: PNM013
MIFTS: 39

Pneumococcal Meningitis malady

Neuronal diseases, Infectious diseases categories

Summaries for Pneumococcal Meningitis

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Pneumococcal infection refers to an infection caused by Streptococcus pneumoniae. more...

MalaCards: Pneumococcal Meningitis, also known as meningitis, pneumococcal, is related to meningitis and pneumonia. An important gene associated with Pneumococcal Meningitis is IRAK4 (interleukin-1 receptor-associated kinase 4), and among its related pathways are Activation of C3 and C5 and Terminal pathway of complement. The compounds estrogen and anaphylatoxin have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and vision/eye.

Aliases & Classifications for Pneumococcal Meningitis

About this section
Sources:
48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

pneumococcal meningitis 48
meningitis, pneumococcal 60


External Ids:

MESH via Orphanet35 D008586
ICD10 via Orphanet26 G00.1
SNOMED-CT via Orphanet57 51169003
UMLS via Orphanet61 C0025295
ICD1025 G00.1

Related Diseases for Pneumococcal Meningitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Pneumococcal Meningitis:



Diseases related to pneumococcal meningitis

Clinical Features for Pneumococcal Meningitis

About this section

Drugs & Therapeutics for Pneumococcal Meningitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pneumococcal Meningitis

Drug clinical trials:

Search ClinicalTrials for Pneumococcal Meningitis

Search NIH Clinical Center for Pneumococcal Meningitis

Search CenterWatch for Pneumococcal Meningitis

Genetic Tests for Pneumococcal Meningitis

About this section

Anatomical Context for Pneumococcal Meningitis

About this section

Animal Models for Pneumococcal Meningitis or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Pneumococcal Meningitis

About this section

Genetic Variations for Pneumococcal Meningitis

About this section

Expression for genes affiliated with Pneumococcal Meningitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pneumococcal Meningitis

Search GEO for disease gene expression data for Pneumococcal Meningitis.

Pathways for genes affiliated with Pneumococcal Meningitis

About this section
Sources:
53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology, 55SinoBiological, 52R&D Systems, 12EMD Millipore
See all sources

Pathways related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9C3, C5
2
Hide members
9.9C5, C3
3
Mucin expression in CF via IL-6, IL-17 signaling pathways
9.8SRC, IRAK4
4
Hide members
9.7TNFRSF1B, SRC
59.7SRC, MMP9
6
Hide members
9.4SRC, C5, C3
7
Hide members
9.4C3, IRAK4, HSPA1A
89.3SRC, MMP9, TNFRSF1B
9
Hide members
9.3IRAK4, CASP3, CASP1
10
Hide members
9.2TNFRSF1B, CASP3, CASP1
11
Hide members
9.2TNFRSF1B, CASP3, CASP1
129.2CASP1, CASP3, TNFRSF1B
139.2CASP1, CASP3, SRC
14
Hide members
9.1IL6, IRAK4, CASP1
15
Hide members
9.0IRAK4, TNFRSF1B, CASP3, CASP1
168.9KMO, IL6, CAT
178.9SRC, MMP9, IL6
188.8C5, IL6, HSPA1A
198.8SRC, MMP9, IRAK4, CASP3
20
Hide members
8.8TNFRSF1B, CAT, CASP3, CASP1
21
Hide members
8.7CASP1, IRAK4, IL6, SRC
228.7CASP3, IL6, MMP9
23
Hide members
8.5HSPA1A, CASP1, CASP3, TNFRSF1B, IRAK4
248.3CASP3, TNFRSF1B, IL6, MMP9
258.2CASP3, IL6, MMP9, SRC
268.2CASP3, IL6, MMP9, SRC
27
Hide members
8.2HSPA1A, CASP3, TNFRSF1B, IL6
288.0CASP3, IRAK4, IL6, SRC, C3
29
Hide members
8.0CASP3, TNFRSF1B, IRAK4, IL6, SRC
307.9HSPA1A, CASP1, CASP3, IL6, C3
317.9C3, C5, IL6, IRAK4, CASP3, CASP1
32
Hide members
7.7CASP3, IRAK4, IL6, MMP9, SRC, C3
33
Hide members
7.6CASP1, CASP3, TNFRSF1B, IL6, MMP9, SRC
34
Hide members
7.5HSPA1A, CASP1, CASP3, TNFRSF1B, IL6, MMP9
35
Hide members
7.5HSPA1A, CASP1, CASP3, TNFRSF1B, IL6, SRC
36
Hide members
7.4HSPA1A, CASP1, CASP3, IRAK4, IL6, C5

Compounds for genes affiliated with Pneumococcal Meningitis

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5TNFRSF1B
2anaphylatoxin4410.5C5
3cycloheximide4410.5CAT
4rotenone4410.4CASP1
5endotoxin4410.2CASP1, TNFRSF1B
6pge24410.0SRC, MMP9
7norepinephrine44 11 2411.9HSPA1A, SRC
8cyclosporin a44 28 5911.9SRC, TNFRSF1B, CASP1
9evodiamine449.7CASP1, CASP3
10minocycline44 1110.6CASP1, MMP9, CASP3
11diphenyleneiodonium449.6CASP1, SRC, CASP3
12staurosporin449.5CASP1, SRC, CASP3
13superoxide44 2410.5CASP3, TNFRSF1B, CASP1
14dutp449.5CASP3, CASP1, TNFRSF1B
15nmda44 2810.5CASP1, SRC, KMO
16trolox449.5CASP1, CAT, CASP3
17zoledronic acid449.5CASP3, MMP9, SRC
18s-nitroso-n-acetylpenicillamine449.4CAT, CASP1, CASP3
19alpha lipoic acid449.4CAT, MMP9, HSPA1A
20helenalin449.3IL6, MMP9, SRC
21manganese superoxide449.3TNFRSF1B, CAT, HSPA1A
22creatinine449.3CASP1, MMP9, C3, HSPA1A
23fluvastatin44 49 28 1112.2CASP1, MMP9, IL6
24salicylic acid44 2810.2CAT, HSPA1A, SRC
25ivig449.1MMP9, IL6, TNFRSF1B
26tpck449.1CASP1, IL6, CASP3
275fluorouracil449.0CASP3, CASP1, TNFRSF1B, SRC
28parthenolide44 210.0IL6, MMP9, CASP3
29ciglitazone44 2810.0IL6, MMP9, CASP3
30neopterin449.0TNFRSF1B, C3, IL6
31serine449.0SRC, TNFRSF1B, C3, MMP9, CASP1
32quercetin44 59 11 2412.0CASP1, CASP3, CAT, HSPA1A
33oxygen44 249.9TNFRSF1B, HSPA1A, CASP1, IRAK4, KMO, C3
34h2o2448.9HSPA1A, CASP1, CAT, TNFRSF1B, SRC
358-isoprostane448.7HSPA1A, CAT, IL6, MMP9
36arsenite44 249.7CASP3, SRC, MMP9, CASP1, HSPA1A
37pdtc448.6CAT, IL6, MMP9, CASP3
38cisplatin44 49 59 1111.6HSPA1A, SRC, TNFRSF1B, CASP3, CASP1
3915-deoxy-delta-12,14-prostaglandin j2448.4CASP3, IL6, HSPA1A
40ly294002448.3CASP3, SRC, MMP9, IL6, TNFRSF1B
41dexamethasone44 49 28 1111.2CASP1, IL6, TNFRSF1B, HSPA1A, MMP9, C3
42cysteine448.1CASP1, CASP3, CAT, TNFRSF1B, MMP9, SRC
43vegf448.0SRC, TNFRSF1B, CASP1, MMP9, IL6, CASP3
44testosterone44 59 11 2410.9CASP1, TNFRSF1B, IL6, MMP9, SRC
45curcumin447.9SRC, MMP9, TNFRSF1B, IL6, CASP3, CAT
46pd 98,059447.9HSPA1A, CASP3, IL6, MMP9, SRC, CASP1
47lactate447.5IL6, MMP9, CASP3, CASP1, HSPA1A, C3
48actinomycin d447.5TNFRSF1B, HSPA1A, CASP1, CASP3, CAT, MMP9
49n acetylcysteine447.4SRC, IL6, MMP9, CAT, CASP3, CASP1
50sb 20358044 598.4MMP9, HSPA1A, CASP1, CASP3, CAT, IL6

GO Terms for genes affiliated with Pneumococcal Meningitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5C3, C5, LGALS9, MMP9, IL6, TNFRSF1B

Biological processes related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation vascular endothelial growth factor productionGO:0105759.9C3, C5
2complement activation, alternative pathwayGO:0069579.6C3, C5
3innate immune responseGO:0450878.9C3, C5, SRC, IRAK4, CASP1
4inflammatory responseGO:0069548.6TNFRSF1B, IL6, C5, C3

Molecular functions related to Pneumococcal Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.0C3, C5, SRC, CAT

Products for genes affiliated with Pneumococcal Meningitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pneumococcal Meningitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet