MCID: PNM013
MIFTS: 40

Pneumococcal Meningitis

Categories: Neuronal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Pneumococcal Meningitis

MalaCards integrated aliases for Pneumococcal Meningitis:

Name: Pneumococcal Meningitis 55
Meningitis, Pneumococcal 69

Classifications:



External Ids:

Orphanet 55 ORPHA55655
MESH via Orphanet 42 D008586
UMLS via Orphanet 70 C0025295
ICD10 via Orphanet 33 G00.1
ICD10 32 G00.1
UMLS 69 C0025295

Summaries for Pneumococcal Meningitis

MalaCards based summary : Pneumococcal Meningitis, also known as meningitis, pneumococcal, is related to meningitis and brain edema. An important gene associated with Pneumococcal Meningitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are TNFR1 Pathway and IL-17 Family Signaling Pathways. The drugs Phenytoin and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and neutrophil, and related phenotypes are cellular and hematopoietic system

Related Diseases for Pneumococcal Meningitis

Diseases related to Pneumococcal Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 meningitis 31.3 MBL2 MMP9
2 brain edema 29.9 GLUL MMP9
3 cerebritis 10.4
4 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
5 pneumonia 10.2
6 neuronitis 10.2
7 bacteremia 2 10.1
8 endocarditis 10.1
9 hydrops, lactic acidosis, and sideroblastic anemia 10.1
10 thrombosis 10.0
11 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.0
12 vasculitis 9.9
13 aging 9.9
14 quadriplegia 9.9
15 aneurysm 9.9
16 brain injury 9.9
17 common variable immunodeficiency 9.9
18 sinusitis 9.9
19 sickle cell disease 9.9
20 labyrinthitis 9.9
21 sphenoid sinusitis 9.9
22 otitis media 9.9
23 endotheliitis 9.9
24 photokeratitis 9.8 MIF MMP9
25 keratitis, hereditary 9.7 MIF MMP9
26 thymoma, familial 9.7
27 cerebral arteritis 9.7
28 cervicitis 9.7
29 glomerulonephritis 9.7
30 pulmonary edema 9.7
31 hemoglobinopathy 9.7
32 chickenpox 9.7
33 stroke, ischemic 9.7
34 hepatitis 9.7
35 streptococcal meningitis 9.7
36 ischemia 9.7
37 pyomyositis 9.7
38 branchiootic syndrome 1 9.7
39 hydrocephalus 9.7
40 cauda equina syndrome 9.7
41 thymoma 9.7
42 eczema herpeticum 9.7
43 west nile virus 9.7
44 optic neuritis 9.7
45 purpura 9.7
46 intracranial hypertension 9.7
47 mungan syndrome 9.7
48 cardiac arrest 9.7
49 aseptic meningitis 9.7
50 bacterial meningitis 9.7

Comorbidity relations with Pneumococcal Meningitis via Phenotypic Disease Network (PDN):


Otitis Media Respiratory Failure

Graphical network of the top 20 diseases related to Pneumococcal Meningitis:



Diseases related to Pneumococcal Meningitis

Symptoms & Phenotypes for Pneumococcal Meningitis

MGI Mouse Phenotypes related to Pneumococcal Meningitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.35 GLUL MAPK10 MIF MMP9 NFKBIE
2 hematopoietic system MP:0005397 9.02 MAPK10 MBL2 MIF MMP9 NFKBIE

Drugs & Therapeutics for Pneumococcal Meningitis

Drugs for Pneumococcal Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Cefotaxime Approved Phase 4 63527-52-6 5742673 456256
4
Cefoxitin Approved Phase 4 35607-66-0 441199
5 Sodium Channel Blockers Phase 4
6 Diuretics, Potassium Sparing Phase 4
7 Anti-Bacterial Agents Phase 4,Phase 2
8 Anticonvulsants Phase 4
9 Antibiotics, Antitubercular Phase 4
10 Analgesics Phase 4
11 Analgesics, Non-Narcotic Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Anti-Infective Agents Phase 4,Phase 2
14 Lactams Phase 4
15 Antipyretics Phase 4
16 beta-Lactams Phase 4
17
Ceftobiprole Approved, Investigational Phase 2 209467-52-7 6918430
18 Ceftobiprole medocaril Phase 2
19 Cephalosporins Phase 2
20
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
21
Vancomycin Approved 1404-90-6 14969 441141
22 Dexamethasone acetate 1177-87-3
23 glucocorticoids
24 Gastrointestinal Agents
25 Heptavalent Pneumococcal Conjugate Vaccine
26 Vaccines
27 Hormone Antagonists
28 Hormones
29 Hormones, Hormone Substitutes, and Hormone Antagonists
30 Antiemetics
31 Anti-Inflammatory Agents
32 Antineoplastic Agents, Hormonal
33 BB 1101
34 Autonomic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4 Phenytoin;placebo
2 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
3 Open and Exploratory Trial to Investigate the Pharmacokinetic of Ceftobiprole Medocaril in Patients With CSF Device Not yet recruiting NCT03317093 Phase 2 Ceftobiprole Medocaril
4 Vancomycin Concentration in Cerebrospinal Fluid During Pneumococcal Meningitis Completed NCT00162578
5 Study Evaluating Pneumococcal Meningitis in the Paediatric Population in Spain Four Years After the Marketing of Prevenar. Completed NCT00227214
6 Child Pneumococcal Serotype Epidemiology In Greece Completed NCT01111214
7 Surveillance of Hospitalised Pneumonia and Bacterial Meningitis in Tône District, Togo, 2010-2013 Recruiting NCT01747369
8 Costa Rica Epidemiological Study on S. Pneumoniae Suspended NCT01308827

Search NIH Clinical Center for Pneumococcal Meningitis

Genetic Tests for Pneumococcal Meningitis

Anatomical Context for Pneumococcal Meningitis

MalaCards organs/tissues related to Pneumococcal Meningitis:

38
Brain, Testes, Neutrophil, Bone, Cortex, Endothelial, Spinal Cord

Publications for Pneumococcal Meningitis

Articles related to Pneumococcal Meningitis:

(show top 50) (show all 613)
# Title Authors Year
1
Reactive vaccination as a control strategy for pneumococcal meningitis outbreaks in the African meningitis belt: Analysis of outbreak data from Ghana. ( 29371015 )
2018
2
Delayed cerebral thrombosis complicating pneumococcal meningitis: an autopsy study. ( 29427117 )
2018
3
Pneumococcal meningitis trends after pneumococcal conjugate vaccine introduction in Colombia: An interrupted time-series analysis. ( 29351491 )
2018
4
Adult Patients with Pneumococcal Meningitis at a Neurosurgical Neurologic Center: Different Predisposing Conditions? ( 29170119 )
2018
5
Novel and preclinical treatment strategies in pneumococcal meningitis. ( 29095719 )
2018
6
Early impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis-Burkina Faso, 2014-2015. ( 29253559 )
2018
7
Quantitative Proteomics of Cerebrospinal Fluid in Paediatric Pneumococcal Meningitis. ( 28765563 )
2017
8
Impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis in children. ( 28711388 )
2017
9
Trends in pneumococcal meningitis hospitalizations following the introduction of the 13-valent pneumococcal conjugate vaccine in the United States. ( 28951086 )
2017
10
Pneumococcal meningitis in Cantabria (Spain) in the pneumococcal conjugate vaccine era (2001-2015). ( 28318182 )
2017
11
Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems. ( 28489958 )
2017
12
Detection of Significant Pneumococcal Meningitis Biomarkers by Ego Network. ( 28247176 )
2017
13
Mannose-binding lectin-deficient genotypes as a risk factor of pneumococcal meningitis in infants. ( 28562692 )
2017
14
B7-H3 Augments Inflammatory Responses and Exacerbates Brain Damage via Amplifying NF-I_B p65 and MAPK p38 Activation during Experimental Pneumococcal Meningitis. ( 28141831 )
2017
15
Risk Factors in Children Older Than 5 Years With Pneumococcal Meningitis: Data From a National Network. ( 28403047 )
2017
16
Surveillance of impact of PCV-10 vaccine on pneumococcal meningitis in Mozambique, 2013 - 2015. ( 28604773 )
2017
17
Pneumococcal meningitis and endocarditis in an infant: possible improved survival with factor V Leiden mutation. ( 28801724 )
2017
18
Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. ( 28086930 )
2017
19
Pneumococcal meningitis-associated bihemispherical acute vasculitic infarcts. ( 28784909 )
2017
20
DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6. ( 29233148 )
2017
21
Diagnostic Dilemma in a 15-Year-Old Boy with Recurrent Pneumococcal Meningitis. ( 28658867 )
2017
22
Case-control study shows that neonatal pneumococcal meningitis cannot be distinguished from group B Streptococcus cases. ( 28508419 )
2017
23
Inhibition of DAMP signaling as an effective adjunctive treatment strategy in pneumococcal meningitis. ( 29096648 )
2017
24
Prevention of Memory Impairment and Neurotrophic Factors Increased by Lithium in Wistar Rats Submitted to Pneumococcal Meningitis Model. ( 29200666 )
2017
25
The Early Adaptive Immune Response in the Pathophysiological Process of Pneumococcal Meningitis. ( 27803171 )
2017
26
Sporadic isolated congenital asplenia with fulminant pneumococcal meningitis: a case report and updated literature review. ( 29254492 )
2017
27
Can infant vaccination prevent pneumococcal meningitis outbreaks in sub-Saharan Africa? ( 28244176 )
2017
28
Role of purinergic signaling in experimental pneumococcal meningitis. ( 28300164 )
2017
29
Pneumococcal meningitis with normal cerebrospinal biochemistry and no pneumococci at microscopy, mimicking a stroke: a case report. ( 28592301 )
2017
30
Pneumococcal Meningitis Before and After Universal Vaccination With Pneumococcal Conjugate Vaccines 7/13, Impact on Pediatric Hospitalization in Public and Nonpublic Institutions, in Uruguay. ( 28661966 )
2017
31
Variation of 46 Innate Immune Genes Evaluated for their Contribution in Pneumococcal Meningitis Susceptibility and Outcome. ( 27432718 )
2016
32
Pneumococcal meningitis outbreaks in sub-Saharan Africa. ( 27305709 )
2016
33
Comparison of the clinical presentations of Naegleria fowleri primary amoebic meningoencephalitis with pneumococcal meningitis: a case-control study. ( 26922583 )
2016
34
The Severity of Infection Determines the Localization of Damage and Extent of Sensorineural Hearing Loss in Experimental Pneumococcal Meningitis. ( 27445150 )
2016
35
Streptococcus pneumoniae capsule determines disease severity in experimental pneumococcal meningitis. ( 27009189 )
2016
36
The wider implications of normal cerebrospinal fluid cellularity in pneumococcal meningitis. ( 26776534 )
2016
37
Depression-Like Adult Behaviors may be a Long-Term Result of Experimental Pneumococcal Meningitis in Wistar Rats Infants. ( 27364961 )
2016
38
Refractory status epilepticus due to pneumococcal meningitis in an infant with congenital immunodeficiency. ( 27606021 )
2016
39
Exome Array Analysis of Susceptibility to Pneumococcal Meningitis. ( 27389768 )
2016
40
Do Innate Immune Gene Variations Contribute to Susceptibility and Severity of Pneumococcal Meningitis? ( 27478066 )
2016
41
Abdominal aortitis and aneurysm impending rupture during pneumococcal meningitis. ( 27477988 )
2016
42
Predictive risk factors for Listeria monocytogenes meningitis compared to pneumococcal meningitis: a multicenter case-control study. ( 27541039 )
2016
43
Dramatic reduction of mortality in pneumococcal meningitis. ( 27716447 )
2016
44
Thioredoxins and Methionine Sulfoxide Reductases in the Pathophysiology of Pneumococcal Meningitis. ( 27368348 )
2016
45
Edaravone attenuates hippocampal damage in an infant mouse model of pneumococcal meningitis by reducing HMGB1 and iNOS expression via the Nrf2/HO-1 pathway. ( 27569388 )
2016
46
Comparative impact of pneumococcal conjugate vaccines on pneumococcal meningitis according to underlying conditions. ( 27595445 )
2016
47
Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA. ( 27348589 )
2016
48
Pneumococcal Meningitis in the PCV13 Era: A Cluster of Cases With Increased Morbidity and Mortality. ( 26902305 )
2016
49
Inhibition of Hippocampal Regeneration by Adjuvant Dexamethasone in Experimental Infant Rat Pneumococcal Meningitis. ( 26824948 )
2016
50
Therapeutic hypothermia and inhalation anesthesia in a patient with severe pneumococcal meningitis and secondary cardiac arrest. ( 27856137 )
2016

Variations for Pneumococcal Meningitis

Expression for Pneumococcal Meningitis

Search GEO for disease gene expression data for Pneumococcal Meningitis.

Pathways for Pneumococcal Meningitis

Pathways related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 GLUL MAPK10 MMP9 NFKBIE
2
Show member pathways
11.83 MAPK10 MMP9 NFKBIE
3
Show member pathways
11.73 MAPK10 MIF NFKBIE
4
Show member pathways
11.63 MAPK10 NFKBIE
5 11.6 MIF MMP9
6
Show member pathways
11.56 MAPK10 NFKBIE
7 11.53 MAPK10 MMP9
8
Show member pathways
11.4 MAPK10 NFKBIE
9 11.27 MAPK10 NFKBIE
10
Show member pathways
11.1 MAPK10 NFKBIE
11
Show member pathways
11.02 MAPK10 MMP9 NFKBIE
12
Show member pathways
11.01 MAPK10 NFKBIE
13 10.78 MAPK10 NFKBIE
14
Show member pathways
10.6 MIF MMP9 NFKBIE

GO Terms for Pneumococcal Meningitis

Cellular components related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ficolin-1-rich granule lumen GO:1904813 8.62 MIF MMP9

Sources for Pneumococcal Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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