MCID: PNM006
MIFTS: 59

Pneumoconiosis malady

Respiratory diseases category

Summaries for Pneumoconiosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Pneumoconiosis is an occupational lung disease and a restrictive lung disease caused by the inhalation... more...

MalaCards: Pneumoconiosis, also known as pneumoconiosis, unspecified, is related to silicosis and lung cancer. An important gene associated with Pneumoconiosis is SOD1 (superoxide dismutase 1, soluble), and among its related pathways are Oxidative Stress Regulatory Pathway (Erythrocyte) and superoxide radicals degradation. The compounds dmpo-oh and manganese superoxide have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and monocytes, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 An interstitial lung disease that is caused by the inhalation of dust.

Aliases & Classifications for Pneumoconiosis

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Pneumoconiosis

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17GeneCards, 18GeneDecks
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Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1silicosis30.9SCGB1A1, FASLG
2lung cancer30.6OGG1
3anthracosis30.6CCL2, SOD1, BMP6
4tuberculosis30.2MBL2, CP
5arthritis30.2CCL2, FTH1, IL2RB
6pulmonary fibrosis30.2CCL2, SOD1, BMP6
7rheumatoid arthritis30.2CCL2, MBL2, FASLG, BMP6, CX3CR1, IL2RB
8sarcoidosis30.0CCL2, SCGB1A1, IL2RB
9pulmonary tuberculosis30.0CAT, MBL2, CP
10pneumonia30.0CCL2, MBL2, SCGB1A1, IL2RB
11idiopathic pulmonary fibrosis30.0CCL2, FASLG, SCGB1A1, BMP6, IL2RB
12interstitial lung disease29.9CCL2
13hypertension29.8CCL2
14liver cirrhosis29.8CP
15esophagitis29.8CAT
16hemosiderosis29.8CP, FTH1
17adenocarcinoma29.8OGG1, FASLG, SCGB1A1, BMP6
18aspergillosis29.8MBL2
19caplan's syndrome10.4
20kaolin pneumoconiosis10.4
21asbestosis10.4
22graphite pneumoconiosis10.2
23baritosis10.2
24byssinosis10.2
25pneumoconiosis due to talc10.2
26bronchitis10.1
27slate pneumoconiosis10.1
28berylliosis10.1
29mixed mineral dust pneumoconiosis10.1
30labrador lung10.1
31pulmonary sarcoidosis10.0
32obstructive lung disease10.0
33silicosiderosis10.0
34uveitis10.0CCL2
35peritonitis10.0CCL2
36endometriosis10.0CCL2
37insulin resistance10.0CCL2
38cervical cancer10.0MBL2
39pancreatitis10.0SOD1
40tonsillitis10.0SOD1
41essential hypertension10.0SOD1
42age related macular degeneration10.0CX3CR1
43hepatitis b10.0MBL2
44rhinitis10.0SCGB1A1
45amyotrophic lateral sclerosis10.0SOD1
46atopy10.0SCGB1A1
47graves' disease10.0FASLG
48viral hepatitis10.0FASLG
49fatty liver disease10.0FTH1
50diabetic cataract10.0CAT

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to pneumoconiosis

Clinical Features for Pneumoconiosis

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Drugs & Therapeutics for Pneumoconiosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pneumoconiosis

Drug clinical trials:

Search ClinicalTrials for Pneumoconiosis

Search NIH Clinical Center for Pneumoconiosis

Search CenterWatch for Pneumoconiosis

Genetic Tests for Pneumoconiosis

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Anatomical Context for Pneumoconiosis

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32MalaCards
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MalaCards organs/tissues related to Pneumoconiosis:

32
Lung, Testes, Monocytes, Skin, Liver, Eye

Animal Models for Pneumoconiosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pneumoconiosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.2CCR2, CCL2, FASLG, SCGB1A1
2MP:000537010.0FTH1, CCR2, CP, IL2RB, FASLG, SOD1
3MP:00053769.8CX3CR1, FTH1, SCGB1A1, MBL2, CCR2, CCL2
4MP:00053879.7SOD1, MBL2, OGG1, CCL2, IL2RB, CCR2
5MP:00053979.6MBL2, CP, IL2RB, CX3CR1, FTH1, FASLG
6MP:00053849.3SOD1, OGG1, FASLG, FTH1, CX3CR1, IL2RB

Publications for Pneumoconiosis

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50PubMed
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Articles related to Pneumoconiosis:

(show top 50)    (show all 542)
idTitleAuthorsYear
1
Interleukin gene polymorphisms in pneumoconiosis. (22580886)
2012
2
Annexin A5 gene polymorphism (-1C/T) and the susceptibility to pneumoconiosis in coal works]. (22804929)
2012
3
Functional state of RBC and neutrophils in pneumoconiosis patients variable in tolerance to dust factor in after contact period]. (22242279)
2011
4
Comparison of digital direct readout radiography with conventional film-screen radiography for the recognition of pneumoconiosis in dust-exposed Chinese workers. (21778659)
2011
5
Possible effect of gene polymorphisms on the release of TNFI+ and IL1 cytokines in coal workers' pneumoconiosis. (20005085)
2011
6
Rheumatoid pneumoconiosis (Caplan's syndrome). (20493416)
2010
7
Hard metal pneumoconiosis with spontaneous bilateral pneumothorax. (20209319)
2010
8
Prevalence of respiratory abnormalities and pneumoconiosis in dental laboratory technicians. (20865565)
2010
9
Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. (19881472)
2010
10
Inorganic agricultural dust exposure causes pneumoconiosis among farmworkers. (20427580)
2010
11
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study. (21475938)
2009
12
Transforming growth factor beta and tumor necrosis factor gene polymorphism and coal worker's pneumoconiosis]. (19493496)
2009
13
Quality of life of coal dust workers without pneumoconiosis in mainland China. (18946192)
2008
14
What are the major points and emerging issues in radiologic imaging for pneumoconiosis surveillance and diagnosis? (18188087)
2008
15
Advanced Pneumoconiosis Among Working Underground Coal Miners-Eastern Kentucky and Southwestern Virginia, 2006Advanced Pneumoconiosis Among Working Underground Coal Miners-Eastern Kentucky and Southwestern Virginia, 2006. (22600370)
2007
16
Long-term outcome after resection of non-small cell lung carcinoma complicated by pneumoconiosis. (16998679)
2006
17
Gene polymorphisms of fibrinolytic enzymes in coal workers' pneumoconiosis. (17649957)
2006
18
Alcohol consumption, lung function, and quality of life in pneumoconiosis. (16046879)
2005
19
Outcome of coal worker's pneumoconiosis with acute respiratory failure. (15006968)
2004
20
Dust concentrations and respiratory risks in coalminers: key risk estimates from the British Pneumoconiosis Field Research. (15150385)
2004
21
Potential effect of tumor necrosis factor-alpha and its receptor II gene polymorphisms on the pathogenesis of coal worker's pneumoconiosis]. (15355698)
2004
22
Chronic necrotizing pulmonary aspergillosis in pneumoconiosis: clinical and radiologic findings in 10 patients. (11796440)
2002
23
Cytokines and cytokine network in silicosis and coal workers' pneumoconiosis. (7656959)
1995
24
Coal worker's pneumoconiosis mimicking pulmonary sarcoidosis. (8062478)
1994
25
How silicosis and coal workers' pneumoconiosis develop--a cellular assessment. (8384379)
1993
26
Classification of radiographs for pneumoconiosis: the Canadian Pneumoconiosis Reading Panel. (8213842)
1993
27
Classification of chest radiographs for pneumoconiosis: a comparison of two methods of reading. (1472446)
1992
28
Slateworker's pneumoconiosis. (1398639)
1992
29
Pulmonary alveolar proteinosis as a component of massive fibrosis in cases of chronic pneumoconiosis. An autopsy study of 79 cases. (1801911)
1991
30
Long-term mortality in miners with coal workers' pneumoconiosis in The Netherlands: a pilot study. (1989436)
1991
31
Silicosis among gemstone workers in South Africa: tiger's-eye pneumoconiosis. (1847003)
1991
32
Pulmonary arteriolar muscularization in coal workers' pneumoconiosis and its correlation with right ventricular hypertrophy. (2145819)
1990
33
Trace metal lung diseases: a new fatal case of hard metal pneumoconiosis. (2095607)
1990
34
A new approach to the study of pneumoconiosis: the nuclear reactor. (2623373)
1989
35
Relationship of lipid secretion and particle size to diffuse interstitial change in pneumoconiosis: a pathogenetic perspective. (2658569)
1989
36
Carborundum pneumoconiosis. Fibers in the mineral activate macrophages to produce fibroblast growth factors and sustain the chronic inflammatory disease. (2924613)
1989
37
Pneumoconiosis in an elderly dentist. (3371114)
1988
38
Does the 1980 ILO classification of pneumoconiosis need a facelift? (3415350)
1988
39
Coal workers' pneumoconiosis in Texas. (6729739)
1984
40
Lung mechanics in relation to radiographic category of coalworkers' simple pneumoconiosis. (6722059)
1984
41
Spontaneous organic dust pneumoconiosis in guinea pigs. (6521155)
1984
42
Clinical and pathological aspects of lung cancer associated with asbestosis and other pneumoconiosis. (6679676)
1983
43
"Labrador lung": an unusual mixed dust pneumoconiosis. (6277443)
1982
44
Prediction of pneumoconiosis risk by bioassays of particulate from occupational exposures. (7181280)
1982
45
The relation between pneumoconiosis and dust exposure in Spanish coal mines with comparative studies of different gravimetric dust samplers. (7181307)
1982
46
Diagnosis of pneumoconiosis. (7299965)
1981
47
Tropical pulmonary eosinophilia and coal worker's pneumoconiosis among Dhanbad coal miners (new observations). (1176164)
1975
48
Rheumatoid pneumoconiosis (Caplan's syndrome). A discussion of the disease and a report of a case in a European Witwatersrand gold miner. (13692590)
1961
49
Kaolin pneumoconiosis. (13577154)
1958
50
Hemosiderosis of the lung due to mitral disease; a report of six cases simulating pneumoconiosis. (18120450)
1949

Genetic Variations for Pneumoconiosis

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Expression for genes affiliated with Pneumoconiosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for genes affiliated with Pneumoconiosis

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49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Pneumoconiosis

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Pneumoconiosis according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1dmpo-oh4410.7CP, CAT, SOD1
2manganese superoxide4410.7CAT, FASLG
3endotoxin4410.7SCGB1A1, FASLG
4dmpo4410.7CP, CAT, SOD1
5dehydroascorbic acid44 1111.7CP, CAT
6thiobarbituric acid4410.7SOD1, CAT, CP
7sodium azide4410.7CP, SOD1, CAT
8azide4410.7CP, SOD1, CAT
9mannitol44 1111.7CAT, FTH1, OGG1
10fenton4410.7CP, CAT, SOD1
11nickel carbonate hydroxide4410.7SOD1, CAT
12bathocuproine4410.6SOD1, CAT
13chromium4410.6OGG1, IL2RB
14deferoxamine44 1111.6CP, SOD1, CAT, FTH1
15fpl 557124410.6CAT, SOD1
16dtpa4410.6SOD1, CP, CAT
17hypoxanthine44 11 2412.6CAT, OGG1, CP, SOD1
18u 83836e4410.6CAT, SOD1
198-oxo-dg4410.6SOD1, CAT, OGG1
20pdtc4410.6CP, CAT, CCL2, SOD1
21malondialdehyde4410.6CAT, OGG1, CP, SOD1
22probucol44 1111.6SOD1, CAT, CCL2
231,3-dimethyl-2-thiourea4410.6CAT, SOD1
24rantes4410.6BMP6, MBL2, IL2RB, FASLG
25sodium nitroprusside4410.5BMP6, CAT, FASLG, CP, SOD1
26tocopherol4410.5CAT, SOD1, CP
27superoxide44 2411.5CP, MBL2, OGG1, CCL2, IL2RB
28ferrihydrite4410.5CP, FTH1
29h2o24410.5CAT, OGG1, FASLG, CP, FTH1
30fe2+4410.5FTH1, CAT, CP
31ferrous ammonium sulfate4410.5CP, FTH1
32ascorbic acid44 2411.5CP, FTH1, FASLG, OGG1, SOD1, CAT
33agar4410.5CCL2, CP, CAT, FASLG, BMP6
34iron44 2411.5CAT, FASLG, SCGB1A1, FTH1, CP, IL2RB
35n acetylcysteine4410.4CCL2, CAT, SOD1, FASLG, IL2RB
368-isoprostane4410.4CCL2, CAT, SOD1
37polysaccharide4410.4CCL2, MBL2, IL2RB, FASLG
38lactate4410.4CP, SOD1, FASLG, BMP6, IL2RB, CAT
39creatinine4410.4CP, IL2RB, BMP6, CCL2, SOD1, SCGB1A1
40oxygen44 2411.4SCGB1A1, FTH1, CX3CR1, IL2RB, CCL2, OGG1
41aspartate4410.3IL2RB, CP, CCL2, MBL2, FASLG, SCGB1A1
42s-nitroso-n-acetylpenicillamine4410.3CP, CAT, SOD1
43spec-t4410.3BMP6, CP, IL2RB
44zinc44 2411.3OGG1, SOD1, MBL2, FASLG, CP, FTH1
45vegf4410.3CP, IL2RB, CX3CR1, BMP6, FASLG, CCL2
46lipid4410.2IL2RB, FTH1, SCGB1A1, MBL2, SOD1, CCL2
47copper44 2411.2CP, FTH1, SOD1, CAT
48nitric oxide44 11 2412.2OGG1, SOD1, MBL2, FASLG, SCGB1A1, CAT
49cyclophosphamide44 49 1112.1IL2RB, FASLG, MBL2
50sodium arsenite4410.0CAT, SOD1, FASLG

GO Terms for genes affiliated with Pneumoconiosis

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16Gene Ontology
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Cellular components related to Pneumoconiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.9CP, BMP6, SCGB1A1, FASLG, MBL2, SOD1

Biological processes related to Pneumoconiosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immune complex clearance by monocytes and macrophagesGO:09026510.5CCR2, CCL2
2regulation of vascular endothelial growth factor productionGO:01057410.5CCL2, CCR2
3chemokine-mediated signaling pathwayGO:07009810.5CX3CR1, CCL2, CCR2
4negative regulation of angiogenesisGO:01652510.4CX3CR1, FASLG, CCL2, CCR2
5cellular iron ion homeostasisGO:00687910.4SOD1, FTH1, CP
6response to glucocorticoid stimulusGO:05138410.4CCL2, SCGB1A1, BMP6
7response to ethanolGO:04547110.3CCL2, OGG1, SOD1
8cellular homeostasisGO:01972510.3CCL2, CCR2
9positive regulation of T cell activationGO:05087010.3CCL2, CCR2
10response to drugGO:04249310.1CCL2, OGG1, SOD1, SCGB1A1
11macrophage chemotaxisGO:04824610.0CX3CR1, CCL2

Molecular functions related to Pneumoconiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR2 chemokine receptor bindingGO:03172710.2CCL2, CCR2
2receptor bindingGO:00510210.2FASLG, MBL2, CAT, CCL2
3ferroxidase activityGO:00432210.0CP, FTH1

Products for genes affiliated with Pneumoconiosis

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  • Antibodies
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Sources for Pneumoconiosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet