MCID: PNM006
MIFTS: 59

Pneumoconiosis malady

Respiratory diseases category

Summaries for Pneumoconiosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Pneumoconiosis is an occupational lung disease and a restrictive lung disease caused by the inhalation... more...

MalaCards: Pneumoconiosis, also known as pneumoconiosis, unspecified, is related to silicosis and lung cancer. An important gene associated with Pneumoconiosis is SOD1 (superoxide dismutase 1, soluble), and among its related pathways are Oxidative Stress Regulatory Pathway (Erythrocyte) and superoxide radicals degradation. The compounds dmpo-oh and manganese superoxide have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and monocytes, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 An interstitial lung disease that is caused by the inhalation of dust.

Aliases & Classifications for Pneumoconiosis

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Pneumoconiosis

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17GeneCards, 18GeneDecks
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Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1silicosis30.9SCGB1A1, FASLG
2lung cancer30.6OGG1
3anthracosis30.6CCL2, SOD1, BMP6
4tuberculosis30.2MBL2, CP
5arthritis30.2CCL2, FTH1, IL2RB
6pulmonary fibrosis30.2CCL2, SOD1, BMP6
7rheumatoid arthritis30.2CCL2, MBL2, FASLG, BMP6, CX3CR1, IL2RB
8sarcoidosis30.0CCL2, SCGB1A1, IL2RB
9pulmonary tuberculosis30.0CAT, MBL2, CP
10pneumonia30.0CCL2, MBL2, SCGB1A1, IL2RB
11idiopathic pulmonary fibrosis30.0CCL2, FASLG, SCGB1A1, BMP6, IL2RB
12interstitial lung disease29.9CCL2
13hypertension29.8CCL2
14liver cirrhosis29.8CP
15esophagitis29.8CAT
16hemosiderosis29.8CP, FTH1
17adenocarcinoma29.8OGG1, FASLG, SCGB1A1, BMP6
18aspergillosis29.8MBL2
19caplan's syndrome10.4
20kaolin pneumoconiosis10.4
21asbestosis10.4
22graphite pneumoconiosis10.2
23baritosis10.2
24byssinosis10.2
25pneumoconiosis due to talc10.2
26bronchitis10.1
27slate pneumoconiosis10.1
28berylliosis10.1
29mixed mineral dust pneumoconiosis10.1
30labrador lung10.1
31pulmonary sarcoidosis10.0
32obstructive lung disease10.0
33silicosiderosis10.0
34uveitis10.0CCL2
35peritonitis10.0CCL2
36endometriosis10.0CCL2
37insulin resistance10.0CCL2
38cervical cancer10.0MBL2
39pancreatitis10.0SOD1
40tonsillitis10.0SOD1
41essential hypertension10.0SOD1
42age related macular degeneration10.0CX3CR1
43hepatitis b10.0MBL2
44rhinitis10.0SCGB1A1
45amyotrophic lateral sclerosis10.0SOD1
46atopy10.0SCGB1A1
47graves' disease10.0FASLG
48viral hepatitis10.0FASLG
49fatty liver disease10.0FTH1
50diabetic cataract10.0CAT

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to pneumoconiosis

Clinical Features for Pneumoconiosis

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Drugs & Therapeutics for Pneumoconiosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pneumoconiosis

Drug clinical trials:

Search ClinicalTrials for Pneumoconiosis

Search NIH Clinical Center for Pneumoconiosis

Search CenterWatch for Pneumoconiosis

Genetic Tests for Pneumoconiosis

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Anatomical Context for Pneumoconiosis

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32MalaCards
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MalaCards organs/tissues related to Pneumoconiosis:

32
Lung, Testes, Monocytes, Eye, Liver, Skin

Animal Models for Pneumoconiosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pneumoconiosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.2SCGB1A1, FASLG, CCL2, CCR2
2MP:000537010.0CP, CCR2, CCL2, OGG1, SOD1, FASLG
3MP:00053769.8CCR2, CCL2, SOD1, MBL2, SCGB1A1, FTH1
4MP:00053879.7CCR2, CCL2, OGG1, SOD1, MBL2, FASLG
5MP:00053979.6CCR2, CCL2, OGG1, SOD1, MBL2, FASLG
6MP:00053849.3OGG1, CAT, CCL2, CCR2, SOD1, FASLG

Publications for Pneumoconiosis

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50PubMed
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Articles related to Pneumoconiosis:

(show top 50)    (show all 542)
idTitleAuthorsYear
1
Development of CAD based on ANN analysis of power spectra for pneumoconiosis in chest radiographs: effect of three new enhancement methods. (24414539)
2014
2
Mixed dust pneumoconiosis occurring in an unusual setting. (24296771)
2013
3
Pneumoconiosis. (23708110)
2013
4
The concomitance of pneumoconiosis and stroke. (23658130)
2013
5
Coal workers' pneumoconiosis with progressive massive fibrosis. (22641681)
2012
6
Computerized analysis of pneumoconiosis in digital chest radiography: effect of artificial neural network trained with power spectra. (21153856)
2011
7
Concurrent pulmonary adenocarcinoma and silicate pneumoconiosis in a red-legged partridge (Alectoris rufa). (21500649)
2011
8
Association of TNF-alpha-238G/A and 308 G/A gene polymorphisms with pulmonary tuberculosis among patients with coal worker's pneumoconiosis. (20514989)
2010
9
Availability of the 6-min walk test in coal workers' pneumoconiosis evaluations. (20525671)
2010
10
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with risk of coal workers' pneumoconiosis. (19492233)
2009
11
Mannose-binding lectin gene polymorphisms and the development of coal workers' pneumoconiosis in Japan. (18496832)
2008
12
Pneumoconiosis and liver cirrhosis are not risk factors for tuberculosis in patients with pulmonary infection. (17539848)
2007
13
Significance of serum sialic acid and ceruloplasmin in early lung fibrosis of pneumoconiosis]. (16600124)
2006
14
Antithetical effect of tumor necrosis factor-alphagene polymorphism on coal workers' pneumoconiosis (CWP). (15940715)
2005
15
Comparison of chest radiography and high-resolution computed tomography findings in early and low-grade coal worker's pneumoconiosis. (15246524)
2004
16
The presence of promatrix metalloproteinase-3 and its relation with different categories of coal workers' pneumoconiosis. (15203551)
2004
17
Dental technician's pneumoconiosis: mineralogical analysis of two cases. (12619195)
2003
18
Pneumoconiosis in a female worker exposed to a primer used in the production of non-stick pans: clinical case. (14619184)
2003
19
Tumor necrosis factor-alpha gene promoter polymorphism in coal workers' pneumoconiosis. (12162435)
2002
20
Silicate pneumoconiosis in hens. (10805978)
2000
21
Pneumoconiosis and tractor ploughing. (10341815)
1999
22
Occurrence and prevention of coal miners' pneumoconiosis in Poland. (10561681)
1999
23
Can the evolution to pneumoconiosis be suspected in coal miners? A longitudinal study. (9700128)
1998
24
Pneumoconiosis. (9307748)
1997
25
Coal mine workers' pneumoconiosis (CWP): in vitro study of the release of organic compounds from coal mine dust in the presence of physiological fluids. (9339218)
1997
26
Mortality of Dutch coal miners in relation to pneumoconiosis, chronic obstructive pulmonary disease, and lung function. (9404317)
1997
27
Atypical mycobacteriosis as a complication of talc pneumoconiosis. (8866607)
1996
28
The survival analyses of 2738 patients with simple pneumoconiosis. (8777450)
1996
29
Secretion and mRNA expression of TNF alpha and IL-6 in the lungs of pneumoconiosis patients. (7599837)
1995
30
Tracheal carcinoma and mixed pneumoconiosis. A causal relationship? (7716357)
1995
31
Complexation of iron by humic-like substances in lung tissue: role in coal workers' pneumoconiosis. (8074240)
1994
32
Immunogenetic studies on HLA-DR in German coal miners with and without coal worker's pneumoconiosis. (7815827)
1994
33
Dust and pneumoconiosis in the South African foundry industry. (7570237)
1994
34
Clinical aspects of coal workers' pneumoconiosis and silicosis. (8456347)
1993
35
Respiratory symptoms, lung function, and pneumoconiosis among self employed dental technicians. (8507597)
1993
36
Coal worker's pneumoconiosis CT assessment in exposed workers in correlation with radiographic findings. (1733890)
1992
37
Development and use of a pneumoconiosis database of human pulmonary inorganic particulate burden in over 400 lungs. (1647058)
1991
38
Pneumoconiosis (silicosis) in the confectionery industry. (2345825)
1990
39
Impaired chemotactic responses of bronchoalveolar leukocytes in experimental pneumoconiosis. (2156037)
1990
40
Comparison of chest radiograph reading methods for assessing progress of pneumoconiosis over 10 years in Wittenoom crocidolite workers. (2155650)
1990
41
Exercise capacity in coal workers' pneumoconiosis: an analysis using causal modelling. (2264843)
1990
42
Recent advances in the pathogenesis and clinical assessment of mineral dust pneumoconioses: asbestosis, silicosis and coal pneumoconiosis. (2691279)
1989
43
Is the desert lung syndrome (nonoccupational dust pneumoconiosis) a variant of pulmonary alveolar microlithiasis? Report of 4 cases with review of the literature. (2549601)
1989
44
Silicosis in women. Experience from the Swedish Pneumoconiosis Register. (4009304)
1985
45
Zeolite exposure and associated pneumoconiosis. (2986911)
1985
46
The incidence and progression of pneumoconiosis over nine years in U.S. coal miners: I. Principal findings. (6517070)
1984
47
Fibre exposure and mortality from pneumoconiosis, respiratory and abdominal malignancies in chrysotile production in Quebec, 1926-75. (6497336)
1984
48
Coalworkers' simple pneumoconiosis and exposure to dust at 10 British coalmines. (7066228)
1982
49
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. (436529)
1979
50
Graphite pneumoconiosis of electrotypers. (5954455)
1966

Genetic Variations for Pneumoconiosis

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Expression for genes affiliated with Pneumoconiosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for genes affiliated with Pneumoconiosis

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49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Pneumoconiosis

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Pneumoconiosis according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1dmpo-oh4410.7CP, CAT, SOD1
2manganese superoxide4410.7CAT, FASLG
3endotoxin4410.7SCGB1A1, FASLG
4dmpo4410.7CP, CAT, SOD1
5dehydroascorbic acid44 1111.7CP, CAT
6thiobarbituric acid4410.7SOD1, CAT, CP
7sodium azide4410.7CP, SOD1, CAT
8azide4410.7CP, SOD1, CAT
9mannitol44 1111.7CAT, FTH1, OGG1
10fenton4410.7CP, CAT, SOD1
11nickel carbonate hydroxide4410.7SOD1, CAT
12bathocuproine4410.6SOD1, CAT
13chromium4410.6OGG1, IL2RB
14deferoxamine44 1111.6CP, SOD1, CAT, FTH1
15fpl 557124410.6CAT, SOD1
16dtpa4410.6SOD1, CP, CAT
17hypoxanthine44 11 2412.6CAT, OGG1, CP, SOD1
18u 83836e4410.6CAT, SOD1
198-oxo-dg4410.6SOD1, CAT, OGG1
20pdtc4410.6CP, CAT, CCL2, SOD1
21malondialdehyde4410.6CAT, OGG1, CP, SOD1
22probucol44 1111.6SOD1, CAT, CCL2
231,3-dimethyl-2-thiourea4410.6CAT, SOD1
24rantes4410.6BMP6, MBL2, IL2RB, FASLG
25sodium nitroprusside4410.5BMP6, CAT, FASLG, CP, SOD1
26tocopherol4410.5CAT, SOD1, CP
27superoxide44 2411.5CP, MBL2, OGG1, CCL2, IL2RB
28ferrihydrite4410.5CP, FTH1
29h2o24410.5CAT, OGG1, FASLG, CP, FTH1
30fe2+4410.5FTH1, CAT, CP
31ferrous ammonium sulfate4410.5CP, FTH1
32ascorbic acid44 2411.5CP, FTH1, FASLG, OGG1, SOD1, CAT
33agar4410.5CCL2, CP, CAT, FASLG, BMP6
34iron44 2411.5CAT, FASLG, SCGB1A1, FTH1, CP, IL2RB
35n acetylcysteine4410.4CCL2, CAT, SOD1, FASLG, IL2RB
368-isoprostane4410.4CCL2, CAT, SOD1
37polysaccharide4410.4CCL2, MBL2, IL2RB, FASLG
38lactate4410.4CP, SOD1, FASLG, BMP6, IL2RB, CAT
39creatinine4410.4CP, IL2RB, BMP6, CCL2, SOD1, SCGB1A1
40oxygen44 2411.4SCGB1A1, FTH1, CX3CR1, IL2RB, CCL2, OGG1
41aspartate4410.3IL2RB, CP, CCL2, MBL2, FASLG, SCGB1A1
42s-nitroso-n-acetylpenicillamine4410.3CP, CAT, SOD1
43spec-t4410.3BMP6, CP, IL2RB
44zinc44 2411.3OGG1, SOD1, MBL2, FASLG, CP, FTH1
45vegf4410.3CP, IL2RB, CX3CR1, BMP6, FASLG, CCL2
46lipid4410.2IL2RB, FTH1, SCGB1A1, MBL2, SOD1, CCL2
47copper44 2411.2CP, FTH1, SOD1, CAT
48nitric oxide44 11 2412.2OGG1, SOD1, MBL2, FASLG, SCGB1A1, CAT
49cyclophosphamide44 49 1112.1IL2RB, FASLG, MBL2
50sodium arsenite4410.0CAT, SOD1, FASLG

GO Terms for genes affiliated with Pneumoconiosis

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16Gene Ontology
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Cellular components related to Pneumoconiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.9CP, BMP6, SCGB1A1, FASLG, MBL2, SOD1

Biological processes related to Pneumoconiosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immune complex clearance by monocytes and macrophagesGO:09026510.5CCR2, CCL2
2regulation of vascular endothelial growth factor productionGO:01057410.5CCL2, CCR2
3chemokine-mediated signaling pathwayGO:07009810.5CX3CR1, CCL2, CCR2
4negative regulation of angiogenesisGO:01652510.4CX3CR1, FASLG, CCL2, CCR2
5cellular iron ion homeostasisGO:00687910.4SOD1, FTH1, CP
6response to glucocorticoid stimulusGO:05138410.4CCL2, SCGB1A1, BMP6
7response to ethanolGO:04547110.3CCL2, OGG1, SOD1
8cellular homeostasisGO:01972510.3CCL2, CCR2
9positive regulation of T cell activationGO:05087010.3CCL2, CCR2
10response to drugGO:04249310.1CCL2, OGG1, SOD1, SCGB1A1
11macrophage chemotaxisGO:04824610.0CX3CR1, CCL2

Molecular functions related to Pneumoconiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR2 chemokine receptor bindingGO:03172710.2CCL2, CCR2
2receptor bindingGO:00510210.2FASLG, MBL2, CAT, CCL2
3ferroxidase activityGO:00432210.0CP, FTH1

Products for genes affiliated with Pneumoconiosis

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Sources for Pneumoconiosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet