MCID: PNM006
MIFTS: 52

Pneumoconiosis malady

Respiratory diseases category

Summaries for Pneumoconiosis

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Pneumoconiosis is an occupational lung disease and a restrictive lung disease caused by the inhalation... more...

MalaCards: Pneumoconiosis, also known as pneumoconiosis, unspecified, is related to anthracosis and tuberculosis. An important gene associated with Pneumoconiosis is SOD1 (superoxide dismutase 1, soluble), and among its related pathways are Oxidative Stress and Amyotrophic lateral sclerosis (ALS). The compounds u 83836e and fpl 55712 have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and monocytes.

Disease Ontology:9 An interstitial lung disease that is caused by the inhalation of dust.

Aliases & Classifications for Pneumoconiosis

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Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 28ICD9CM, 36MeSH, 26ICD10
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Related Diseases for Pneumoconiosis

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18GeneCards, 19GeneDecks
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Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1anthracosis30.8CCL2, SOD1
2tuberculosis30.5CP
3pulmonary fibrosis30.3CCL2, SOD1
4hemosiderosis30.0CP
5pulmonary tuberculosis30.0CAT, CP
6silicosis10.7
7graphite pneumoconiosis10.5
8caplan's syndrome10.5
9lung cancer10.5
10asbestosis10.4
11kaolin pneumoconiosis10.4
12pulmonary function10.3
13byssinosis10.2
14pneumoconiosis due to talc10.2
15baritosis10.2
16arthritis10.2
17rheumatoid arthritis10.2
18bronchitis10.2
19berylliosis10.2
20mixed mineral dust pneumoconiosis10.2
21labrador lung10.2
22eales disease10.1SOD1
23hypermethioninemia10.1SOD1
24aceruloplasminemia10.1CP
25diabetic cataract10.1CAT
26slate pneumoconiosis10.1
27idiopathic pulmonary fibrosis10.1
28pneumonia10.1
29sarcoidosis10.1
30mycobacterium malmoense10.1
31silicosiderosis10.1
32menkes disease10.1SOD1, CP
33senile cataract10.1SOD1, CAT
34alcoholic liver cirrhosis10.1SOD1, CAT
35chronic granulomatous disease10.1SOD1, CAT
36gastritis10.1CAT
37arteriosclerosis10.1CCL2, SOD1
38vitiligo10.0CAT, SOD1
39male infertility10.0CAT, SOD1
40eye disease10.0CAT, CCL2
41hyperhomocysteinemia10.0CCL2, SOD1
42prion disease10.0CAT, CP
43wilson disease10.0CAT, SOD1, CP
44bronchiolitis10.0
45interstitial lung disease10.0
46asthma10.0CCL2, CP
47parkinson's disease10.0CAT, SOD1, CP
48cork-handlers' disease10.0CAT, CCL2, SOD1
49vascular disease10.0CAT, CCL2, SOD1
50primary hyperoxaluria10.0SOD1, CCL2, CAT

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to pneumoconiosis

Symptoms for Pneumoconiosis

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Drugs & Therapeutics for Pneumoconiosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Pneumoconiosis

Drug clinical trials:

Search ClinicalTrials for Pneumoconiosis

Search NIH Clinical Center for Pneumoconiosis

Search CenterWatch for Pneumoconiosis

Genetic Tests for Pneumoconiosis

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Anatomical Context for Pneumoconiosis

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34MalaCards
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MalaCards organs/tissues related to Pneumoconiosis:

34
Lung, Testes, Monocytes, Skin, Liver, Eye

Animal Models for Pneumoconiosis or affiliated genes

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Publications for Pneumoconiosis

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53PubMed
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Articles related to Pneumoconiosis:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Associations between tumor necrosis factor alpha gene -238 G/A and -308 G/A polymorphisms and the risk of pneumoconiosis: update of a meta-analysis. (23919499)
2013
2
Mixed dust pneumoconiosis occurring in an unusual setting. (24296771)
2013
3
Pneumoconiosis. (23708110)
2013
4
Interleukin gene polymorphisms in pneumoconiosis. (22580886)
2012
5
Miners compensated for pneumoconiosis and glutathione s-transferases M1 and T1 genotypes. (22686319)
2012
6
Functional state of RBC and neutrophils in pneumoconiosis patients variable in tolerance to dust factor in after contact period]. (22242279)
2011
7
Denim sandblasters' pneumoconiosis. (21466064)
2011
8
Rheumatoid pneumoconiosis (Caplan's syndrome). (20493416)
2010
9
What component of coal causes coal workers' pneumoconiosis? (19333134)
2009
10
Coal workers' pneumoconiosis-related years of potential life lost before age 65 years - United States, 1968-2006. (20032926)
2009
11
Airway function and respiratory resistance in Taiwanese coal workers with simple pneumoconiosis. (19664351)
2009
12
Cytogenetic monitoring of coal workers and patients with coal workers' pneumoconiosis in Turkey. (18288720)
2008
13
Clinical study on pneumoconiosis with pulmonary thromboembolism]. (18302891)
2008
14
Activity of superoxide dismutase and level of lipid peroxidation in pneumoconiosis patients]. (17908436)
2007
15
Wood charcoal and activated carbon dust pneumoconiosis in three workers. (17315177)
2007
16
Long-term outcome after resection of non-small cell lung carcinoma complicated by pneumoconiosis. (16998679)
2006
17
Relationship between pneumoconiosis and the polymorphisms of HLA-DRB1*, DQB1* genes]. (16188098)
2005
18
Changing patterns of pneumoconiosis mortality--United States, 1968-2000. (15269698)
2004
19
Pneumoconiosis in rush mat workers exposed to clay dye "sendo" dust: clinical, radiologic, and histopathologic features in seven patients. (14769759)
2004
20
Study on the expression of C-erbB-2 gene in coal miners with pneumoconiosis complicated by pulmonary cancer]. (14761474)
2003
21
Tumor necrosis factor-alpha gene promoter polymorphism in coal workers' pneumoconiosis. (12162435)
2002
22
Centennial photo page. Silicosis and a few of the other pneumoconiosies: observations on certain aspects of the problem, with emphasis on the role of the radiologist. 1958. (10915663)
2000
23
Mineralogy of lung tissue in dental laboratory technicians' pneumoconiosis. (10386356)
1999
24
Radiologic and pathologic characteristics of mixed dust pneumoconiosis. (8897618)
1996
25
Silicate pneumoconiosis in pigs: optical and scanning electron microscopical investigations with X-ray microanalysis. (8040388)
1994
26
Fuller's earth (montmorillonite) pneumoconiosis. (7951799)
1994
27
Complexation of iron by humic-like substances in lung tissue: role in coal workers' pneumoconiosis. (8074240)
1994
28
Coal workers' pneumoconiosis. (1511552)
1992
29
Lung cancer risk among pneumoconiosis patients in Japan, with special reference to silicotics. (2164508)
1990
30
Pneumoconiosis (silicosis) in the confectionery industry. (2345825)
1990
31
Radiographic type p pneumoconiosis: high-resolution CT. (2928514)
1989
32
Siliceous pneumoconiosis in two dogs. (2715401)
1989
33
Resting gas exchange in nonsmoking bituminous-coal miners with simple pneumoconiosis. (2500687)
1989
34
Pneumoconiosis in an elderly dentist. (3371114)
1988
35
Pneumoconiosis in carbon electrode workers. (3230438)
1988
36
Lung and blood lymphocyte subsets in asbestosis and in mixed dust pneumoconiosis. (3792062)
1987
37
A case-control study to investigate the association between indices of dust exposure and the development of radiologic pneumoconiosis. (3439812)
1987
38
Epidemiologic studies of Scottish oil shale workers: II. Lung function in shale workers' pneumoconiosis. (3717167)
1986
39
Quantitative relations between exposure to respirable coalmine dust and coalworkers' simple pneumoconiosis in men who have worked as miners but have left the coal industry. (3718902)
1986
40
Morphology and pathogenesis of pneumoconiosis in dental technicians. (4001030)
1985
41
Experimental pneumoconiosis due to dusts of ore mines. II. (3939086)
1985
42
An application of kappa-type analyses to interobserver variation in classifying chest radiographs for pneumoconiosis. (6729290)
1984
43
Antimoniosis: a particular form of pneumoconiosis. I. Etiology, clinical and X-ray findings. (6222000)
1983
44
Does coal workers' pneumoconiosis predict to lung cancer? Some evidence from a case-control study. (6632816)
1983
45
Epidemiologic and histologic observations on lung cancer in pneumoconiosis population. (7172143)
1982
46
Irregular opacities in coalworkers' pneumoconiosis--correlation with pulmonary function and pathology. (7181305)
1982
47
Nepheline rock dust pneumoconiosis. A report of 2 cases. (7053544)
1982
48
Graphite pneumoconiosis of electrotypers. (5954455)
1966
49
Farmer's lung; a form of pneumoconiosis due to organic dusts. (13498211)
1958
50
Kaolin pneumoconiosis. (13577154)
1958

Variations for Pneumoconiosis

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Expression for genes affiliated with Pneumoconiosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for genes affiliated with Pneumoconiosis

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 52PharmGKB, 56Reactome, 61Thomson Reuters
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Pathways related to Pneumoconiosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CAT, SOD1
2
Show member pathways
Amyotrophic lateral sclerosis (ALS)39
9.7CAT, SOD1
39.7CAT, SOD1
4
Show member pathways
9.7SOD1, CAT
5
Show member pathways
Vitamin B12 Metabolism39
9.7SOD1, CAT
69.7CAT, SOD1
7
Show member pathways
9.7CAT, SOD1
8
Show member pathways
thioredoxin pathway39
9.3SOD1, CCL2, CAT
9
Show member pathways
9.2SOD1, CP, HSPA1L

Compounds for genes affiliated with Pneumoconiosis

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Sources:
46Novoseek, 12DrugBank, 25HMDB
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Compounds related to Pneumoconiosis according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1u 83836e4610.1SOD1, CAT
2fpl 557124610.1SOD1, CAT
3nickel carbonate hydroxide4610.1SOD1, CAT
4bathocuproine4610.1SOD1, CAT
5randox4610.1CP, SOD1
61,3-dimethyl-2-thiourea4610.1SOD1, CAT
7alpha-phenyl-n-tert-butylnitrone4610.1SOD1, CAT
8ionol4610.1SOD1, CAT
9n-(2-mercaptopropionyl)glycine4610.1SOD1, CAT
10trimetazidine4610.1CAT, SOD1
11tempol4610.1CAT, SOD1
12pyrogallol4610.0SOD1, CAT
13zinc superoxide4610.0SOD1, CAT
14oxypurinol4610.0SOD1, CAT
15propyl gallate4610.0SOD1, CAT
16benzoate4610.0SOD1, CAT
17nacn469.9CAT, SOD1
18ptio469.9CAT, SOD1
19diphenyliodonium469.9CAT, SOD1
20dmpo-oh469.8CAT, SOD1, CP
21dmpo469.8CAT, SOD1, CP
22thiobarbituric acid469.8CAT, SOD1, CP
23sodium azide469.8CAT, SOD1, CP
24azide469.8CP, SOD1, CAT
25fenton469.8CAT, SOD1, CP
26dehydroascorbic acid46 1210.8CAT, SOD1, CP
27dtpa469.8CP, SOD1, CAT
28tocopherol469.8CP, SOD1, CAT
29s-nitroso-n-acetylpenicillamine469.8CAT, SOD1, CP
30deferoxamine46 1210.8CP, SOD1, CAT
31hypoxanthine46 25 1211.7CP, SOD1, CAT
32selenium46 2510.7CAT, SOD1, CP
33betacarotene469.7CP, SOD1, CAT
34citrinin469.7SOD1, CAT
35malondialdehyde469.7CP, SOD1, CAT
36probucol46 1210.7CAT, CCL2, SOD1
37ferric ammonium citrate469.7CAT, CP
388-isoprostane469.7CAT, CCL2, SOD1
39uric acid46 2510.7CP, SOD1, CAT
40alpha lipoic acid469.7CAT, CCL2, SOD1
41diphenyleneiodonium469.7CAT, CCL2, SOD1
42vitamin-e469.6CP, SOD1, CAT
43levodopa46 1210.6CP, SOD1, CAT
44thiourea469.6SOD1, CAT
45alpha tocopherol469.6CP, SOD1, CAT
46sodium nitroprusside469.5CP, SOD1, CAT
47mannitol46 1210.4CAT, SOD1, CP
48pdtc469.3CP, SOD1, CCL2, CAT
49superoxide46 2510.1CAT, CCL2, SOD1, CP
50egcg469.0CAT, CCL2, SOD1

GO Terms for genes affiliated with Pneumoconiosis

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17Gene Ontology
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Cellular components related to Pneumoconiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.7CAT, SOD1
2mitochondrial intermembrane spaceGO:0057589.4CAT, SOD1

Biological processes related to Pneumoconiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to ethanolGO:0454719.7CCL2, SOD1
2response to heatGO:0094089.6CCL2, SOD1
3cellular iron ion homeostasisGO:0068799.5SOD1, CP

Molecular functions related to Pneumoconiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.8SOD1, CP
2chaperone bindingGO:0510879.5SOD1, CP

Products for genes affiliated with Pneumoconiosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pneumoconiosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet