MCID: PNM006
MIFTS: 50

Pneumoconiosis malady

Respiratory category

Summaries for Pneumoconiosis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Pneumoconiosis is an occupational lung disease and a restrictive lung disease caused by the inhalation... more...

MalaCards: Pneumoconiosis, also known as pneumoconiosis, unspecified, is related to silicosis and anthracosis. An important gene associated with Pneumoconiosis is SOD1 (superoxide dismutase 1, soluble), and among its related pathways are Oxidative Stress Regulatory Pathway (Erythrocyte) and superoxide radicals degradation. The compounds dmpo-oh and manganese superoxide have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 An interstitial lung disease that is caused by the inhalation of dust.

Aliases & Classifications for Pneumoconiosis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Related Diseases for Pneumoconiosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pneumoconiosis family:

pneumoconiosis due to talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1silicosis31.0SCGB1A1, FASLG
2anthracosis30.6CCL2, SOD1, BMP6
3tuberculosis30.3MBL2, CP
4arthritis30.3CCL2, FTH1, IL2RB
5pulmonary tuberculosis30.1CAT, MBL2, CP
6idiopathic pulmonary fibrosis30.1CCL2, FASLG, SCGB1A1, BMP6, IL2RB
7hemosiderosis29.8CP, FTH1
8adenocarcinoma29.8OGG1, FASLG, SCGB1A1, BMP6
9aspergillosis29.8MBL2
10graphite pneumoconiosis10.5
11caplan's syndrome10.5
12kaolin pneumoconiosis10.5
13asbestosis10.4
14pulmonary function10.3
15slate pneumoconiosis10.2
16baritosis10.2
17byssinosis10.2
18pneumoconiosis due to talc10.2
19labrador lung10.2
20bronchitis10.2
21mixed mineral dust pneumoconiosis10.2
22pulmonary disease, chronic obstructive10.2
23pulmonary sarcoidosis10.1
24berylliosis10.1
25silicosiderosis10.1
26mycobacterium malmoense10.1
27bronchiolitis10.0
28uveitis10.0CCL2
29hypertension10.0CCL2
30peritonitis10.0CCL2
31endometriosis10.0CCL2
32insulin resistance10.0CCL2
33lung cancer10.0OGG1
34pancreatitis10.0SOD1
35cervical cancer10.0MBL2
36tonsillitis10.0SOD1
37essential hypertension10.0SOD1
38age related macular degeneration10.0CX3CR1
39hepatitis b10.0MBL2
40rhinitis10.0SCGB1A1
41amyotrophic lateral sclerosis10.0SOD1
42interstitial lung disease10.0CCL2
43atopy10.0SCGB1A1
44liver cirrhosis10.0CP
45graves' disease10.0FASLG
46viral hepatitis10.0FASLG
47fatty liver disease10.0FTH1
48esophagitis10.0CAT
49diabetic cataract10.0CAT
50obesity10.0CCL2

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to pneumoconiosis

Clinical Features for Pneumoconiosis

Drugs & Therapeutics for Pneumoconiosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pneumoconiosis

Drug clinical trials:

Search ClinicalTrials for Pneumoconiosis

Search NIH Clinical Center for Pneumoconiosis

Search CenterWatch for Pneumoconiosis

Genetic Tests for Pneumoconiosis

Anatomical Context for Pneumoconiosis

Animal Models for Pneumoconiosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Pneumoconiosis

Sources:
51PubMed
See all sources

Articles related to Pneumoconiosis:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
Evaluation of the oblique fissure on lateral chest radiographs in coal workers pneumoconiosis. (23731051)
2013
2
Diagnostic challenge of a complication of pneumoconiosis. (23960154)
2013
3
Leukotrienes B4, C4, D4 and E4 in the exhaled breath condensate (EBC), blood and urine in patients with pneumoconiosis. (22785421)
2012
4
Coal workers' pneumoconiosis in the United States: regional differences 40 years after implementation of the 1969 Federal Coal Mine Health and Safety Act. (21597107)
2011
5
Wall abscess due to Mycobacterium avium intracellulare (MAI) in a patient with pneumoconiosis. (21316138)
2011
6
Prevalence characteristics and prediction of coal workers' pneumoconiosis in the Tiefa Colliery in China. (19672010)
2009
7
Rheumatoid pneumoconiosis (Caplan's syndrome) with a classical presentation. (19820822)
2009
8
Pilot project in developing community rehabilitation service for migrant workers suffering from pneumoconiosis in Mainland China. (18198437)
2008
9
Activity of superoxide dismutase and level of lipid peroxidation in pneumoconiosis patients]. (17908436)
2007
10
A simple diagnostic model for ruling out pneumoconiosis among construction workers. (17409183)
2007
11
General aspect of pneumoconiosis in Turkey. (21938215)
2007
12
Fatal hemoptysis after suction through endotracheal tube in a patient with pneumoconiosis--a case report. (15346707)
2004
13
Pneumoconiosis prevalence among working coal miners examined in federal chest radiograph surveillance programs--United States, 1996-2002. (12733865)
2003
14
Pneumoconiosis in a vermiculite end-product user. (12874855)
2003
15
Chest radiography in the diagnosis of pneumoconiosis. (11934147)
2002
16
Flour mill lung: a pneumoconiosis of mixed aetiology. (12206482)
2002
17
Genotype and phenotype in susceptibility to coal workers' pneumoconiosis. the use of cytokines in perspective. (11816820)
2001
18
Pathology and pathophysiology of pneumoconiosis. (10741774)
2000
19
Pneumoconiosis: a study of its effect on miners' health in South Wales 1900-1980. (10347463)
1999
20
Recent trends of age-specific pneumoconiosis mortality rates in the United States, 1985-1996: coal workers' pneumoconiosis, asbestosis, and silicosis. (10633240)
1999
21
p53 and Bcl-2 expression in pneumoconiosis-related pre-cancerous lesions and lung cancers: frequent and preferential p53 expression in pneumoconiotic bronchiolar dysplasias. (9466648)
1998
22
Obliterative central bronchitis due to mineral dust in patients with pneumoconiosis. (9448018)
1998
23
Three cases of dental technician's pneumoconiosis related to cobalt-chromium-molybdenum dust exposure. (8617099)
1996
24
Rare earth (cerium oxide) pneumoconiosis: analytical scanning electron microscopy and literature review. (8552576)
1995
25
Coal workers' pneumoconiosis. (1511552)
1992
26
Pulmonary clearance of fibrous and angular SiC particulates in the sheep model of pneumoconiosis. (1444071)
1992
27
Impact of arterial blood gas analysis in disability evaluation of the bituminous coal miner with simple pneumoconiosis. (1564579)
1992
28
Dust exposure and pneumoconiosis in a South African pottery. 1. Study objectives and dust exposure. (1637705)
1992
29
Hard metal pneumoconiosis and the association of tumor necrosis factor-alpha. (1456582)
1992
30
Computed tomographic evaluation of silicosis and coal workers' pneumoconiosis. (1410306)
1992
31
Non-fibrous zeolite induced experimental pneumoconiosis in rats. (1664341)
1991
32
Hut lung: a domestically acquired pneumoconiosis of mixed aetiology in rural women. (2068688)
1991
33
Presence of stable coal radicals in autopsied coal miners' lungs and its possible correlation to coal workers' pneumoconiosis. (1663327)
1991
34
Presence of acute phase response in coal workers' pneumoconiosis. (1707651)
1991
35
Graphite pneumoconiosis and its declining prevalence in Sri Lanka. (2607576)
1989
36
Differences in lung function and prevalence of pneumoconiosis between two kaolin plants. (2590641)
1989
37
Marrow granulomas in coal workers' pneumoconiosis. A histologic study with elemental analysis. (2833095)
1988
38
Lung and blood lymphocyte subsets in asbestosis and in mixed dust pneumoconiosis. (3792062)
1987
39
Quantitative relations between exposure to respirable coalmine dust and coalworkers' simple pneumoconiosis in men who have worked as miners but have left the coal industry. (3718902)
1986
40
Morphology and pathogenesis of pneumoconiosis in dental technicians. (4001030)
1985
41
Kaolin dust concentrations and pneumoconiosis at a kaolin mine. (6463912)
1984
42
Antimoniosis: a particular form of pneumoconiosis. I. Etiology, clinical and X-ray findings. (6222000)
1983
43
Kaolin pneumoconiosis. A case report. (6688946)
1983
44
The pathology of asbestos-associated diseases of the lungs and pleural cavities: diagnostic criteria and proposed grading schema. Report of the Pneumoconiosis Committee of the College of American Pathologists and the National Institute for Occupational Safety and Health. (6897166)
1982
45
Serologic changes in pneumoconiosis and progressive massive fibrosis of coal workers. (6797334)
1981
46
Baritosis: a benign pneumoconiosis. (1257935)
1976
47
Rheumatoid pneumoconiosis. A case of Caplan's syndrome in a chalk-mine worker. (13928349)
1963
48
Graphite pneumoconiosis. (14868768)
1951
49
Graphite pneumoconiosis. (15403150)
1950
50
Observations on the development of graphite pneumoconiosis. (18912047)
1948

Genetic Variations for Pneumoconiosis

Expression for genes affiliated with Pneumoconiosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for genes affiliated with Pneumoconiosis

Sources:
50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 52QIAGEN, 30KEGG
See all sources

Compounds for genes affiliated with Pneumoconiosis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Pneumoconiosis according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1dmpo-oh4510.7CP, CAT, SOD1
2manganese superoxide4510.7CAT, FASLG
3endotoxin4510.7SCGB1A1, FASLG
4dmpo4510.7CP, CAT, SOD1
5dehydroascorbic acid45 1111.7CP, CAT
6thiobarbituric acid4510.7SOD1, CAT, CP
7sodium azide4510.7CP, SOD1, CAT
8azide4510.7CP, SOD1, CAT
9mannitol45 1111.7CAT, FTH1, OGG1
10fenton4510.7CP, CAT, SOD1
11nickel carbonate hydroxide4510.7SOD1, CAT
12bathocuproine4510.6SOD1, CAT
13chromium4510.6OGG1, IL2RB
14deferoxamine45 1111.6CP, SOD1, CAT, FTH1
15fpl 557124510.6CAT, SOD1
16dtpa4510.6SOD1, CP, CAT
17hypoxanthine45 11 2412.6CAT, OGG1, CP, SOD1
18u 83836e4510.6CAT, SOD1
198-oxo-dg4510.6SOD1, CAT, OGG1
20pdtc4510.6CP, CAT, CCL2, SOD1
21malondialdehyde4510.6CAT, OGG1, CP, SOD1
22probucol45 1111.6SOD1, CAT, CCL2
231,3-dimethyl-2-thiourea4510.6CAT, SOD1
24rantes4510.6BMP6, MBL2, IL2RB, FASLG
25sodium nitroprusside4510.5BMP6, CAT, FASLG, CP, SOD1
26tocopherol4510.5CAT, SOD1, CP
27superoxide45 2411.5CP, MBL2, OGG1, CCL2, IL2RB
28ferrihydrite4510.5CP, FTH1
29h2o24510.5CAT, OGG1, FASLG, CP, FTH1
30fe2+4510.5FTH1, CAT, CP
31ferrous ammonium sulfate4510.5CP, FTH1
32ascorbic acid45 2411.5CP, FTH1, FASLG, OGG1, SOD1, CAT
33agar4510.5CCL2, CP, CAT, FASLG, BMP6
34iron45 2411.5CAT, FASLG, SCGB1A1, FTH1, CP, IL2RB
35n acetylcysteine4510.4CCL2, CAT, SOD1, FASLG, IL2RB
368-isoprostane4510.4CCL2, CAT, SOD1
37polysaccharide4510.4CCL2, MBL2, IL2RB, FASLG
38lactate4510.4CP, SOD1, FASLG, BMP6, IL2RB, CAT
39creatinine4510.4CP, IL2RB, BMP6, CCL2, SOD1, SCGB1A1
40oxygen45 2411.4SCGB1A1, FTH1, CX3CR1, IL2RB, CCL2, OGG1
41aspartate4510.3IL2RB, CP, CCL2, MBL2, FASLG, SCGB1A1
42s-nitroso-n-acetylpenicillamine4510.3CP, CAT, SOD1
43spec-t4510.3BMP6, CP, IL2RB
44zinc45 2411.3OGG1, SOD1, MBL2, FASLG, CP, FTH1
45vegf4510.3CP, IL2RB, CX3CR1, BMP6, FASLG, CCL2
46lipid4510.2IL2RB, FTH1, SCGB1A1, MBL2, SOD1, CCL2
47copper45 2411.2CP, FTH1, SOD1, CAT
48nitric oxide45 11 2412.2OGG1, SOD1, MBL2, FASLG, SCGB1A1, CAT
49cyclophosphamide45 50 1112.1IL2RB, FASLG, MBL2
50sodium arsenite4510.0CAT, SOD1, FASLG

GO Terms for genes affiliated with Pneumoconiosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Pneumoconiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.9CP, BMP6, SCGB1A1, FASLG, MBL2, SOD1

Biological processes related to Pneumoconiosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immune complex clearance by monocytes and macrophagesGO:09026510.5CCR2, CCL2
2regulation of vascular endothelial growth factor productionGO:01057410.5CCR2, CCL2
3chemokine-mediated signaling pathwayGO:07009810.5CX3CR1, CCR2, CCL2
4negative regulation of angiogenesisGO:01652510.4CCL2, CCR2, CX3CR1, FASLG
5cellular iron ion homeostasisGO:00687910.4CP, FTH1, SOD1
6response to glucocorticoid stimulusGO:05138410.4CCL2, SCGB1A1, BMP6
7response to ethanolGO:04547110.3SOD1, OGG1, CCL2
8cellular homeostasisGO:01972510.3CCL2, CCR2
9positive regulation of T cell activationGO:05087010.3CCR2, CCL2
10response to drugGO:04249310.1SCGB1A1, SOD1, OGG1, CCL2
11macrophage chemotaxisGO:04824610.0CCL2, CX3CR1

Molecular functions related to Pneumoconiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR2 chemokine receptor bindingGO:03172710.2CCL2, CCR2
2receptor bindingGO:00510210.2FASLG, MBL2, CAT, CCL2
3ferroxidase activityGO:00432210.0CP, FTH1

Products for genes affiliated with Pneumoconiosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pneumoconiosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet