MCID: PNM006
MIFTS: 51

Pneumoconiosis malady

Categories: Respiratory diseases

Aliases & Classifications for Pneumoconiosis

Aliases & Descriptions for Pneumoconiosis:

Name: Pneumoconiosis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10316
ICD10 33 J64
ICD9CM 35 505
MeSH 42 D011009
NCIt 47 C26861
UMLS 69 C0032273

Summaries for Pneumoconiosis

Disease Ontology : 12 An interstitial lung disease that is caused by the inhalation of dust.

MalaCards based summary : Pneumoconiosis is related to mixed mineral dust pneumoconiosis and slate pneumoconiosis. An important gene associated with Pneumoconiosis is CAT (Catalase), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Iron and Deferiprone have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and monocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Wikipedia : 71 Pneumoconiosis is an occupational lung disease and a restrictive lung disease caused by the inhalation... more...

Related Diseases for Pneumoconiosis

Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
id Related Disease Score Top Affiliating Genes
1 mixed mineral dust pneumoconiosis 32.9 CCL2 CXCL8 IL6
2 slate pneumoconiosis 32.7 CCL2 HSPA1L TNF
3 asbestosis 32.2 CXCL8 IL6 TNF
4 tuberculosis 30.3 CCL2 IL1B IL6 TNF
5 pulmonary tuberculosis 29.6 CXCL8 IL6 MUC5B TNF
6 pulmonary eosinophilia 29.5 CCL2 CXCL8 IL1B IL6 TNF
7 rheumatoid arthritis 29.4 CAT CCL2 CXCL8 IL1A IL1B IL6
8 baritosis 29.1 CAT CCL2 CP CXCL8 FAS FASLG
9 pneumoconiosis due to talc 12.0
10 kaolin pneumoconiosis 12.0
11 graphite pneumoconiosis 11.9
12 silicosis 11.9
13 anthracosis 11.8
14 caplan's syndrome 11.6
15 labrador lung 11.4
16 silicosiderosis 11.3
17 berylliosis 11.3
18 aluminium lung 10.7
19 nontuberculous mycobacterial lung disease 10.7
20 intussusception 10.4 IL1B TNF
21 twin-to-twin transfusion syndrome 10.3 FAS IL1B TNF
22 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
23 anthracosilicosis 10.3
24 bipolar i disorder 10.3 IL1B IL6 TNF
25 human immunodeficiency virus infectious disease 10.3 IL1B IL6 TNF
26 tinea capitis 10.3 IL1B IL6 TNF
27 dextrocardia 10.3 IL1B IL6 TNF
28 preaxial polydactyly of fingers 10.3 IL6 TGFB1 TNF
29 pseudo-meigs syndrome 10.3 FAS FASLG TNF
30 benign neonatal seizures 10.3 IL1B IL6 TNF
31 amyotrophic lateral sclerosis type 14 10.3 CXCL8 IL1B TNF
32 parkinson disease 11 10.3 CXCL8 IL1B TNF
33 plantar wart 10.3 CXCL8 TGFB1 TNF
34 breast adenomyoepithelioma 10.3 FAS FASLG IL1B
35 mineral metabolism disease 10.3 IL1B IL6 TNF
36 migraine with aura 10.3 IL1B IL6 TNF
37 hereditary night blindness 10.3 IL6 TGFB1 TNF
38 sacrococcygeal teratoma 10.3 CAT SOD1 TNF
39 keratoconus 10.3 IL1B IL6 TNF
40 splenic artery aneurysm 10.2 IL1B IL6 TNF
41 cholera 10.2 IL1B IL6 TGFB1
42 pancreas lymphoma 10.2 IL1B IL6 TNF
43 cerebellar disease 10.2 IL1A IL1B TNF
44 nasal cavity cancer 10.2 CXCL8 IL1B TNF
45 rift valley fever 10.2 IL1B IL6 TNF
46 status epilepticus 10.2 CCL2 IL1B TNF
47 oculomotor nerve paralysis 10.2 CXCL8 IL1B IL6
48 thymic neuroendocrine carcinoma 10.2 CXCL8 IL6 TNF
49 common peroneal nerve lesion 10.2 CXCL8 IL1B IL6
50 ulcerative proctitis 10.2 CCL2 CXCL8 TNF

Comorbidity relations with Pneumoconiosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Chronic Myocardial Ischemia Familial Atrial Fibrillation
Heart Disease Ischemic Heart Disease
Postinflammatory Pulmonary Fibrosis Prostatic Hypertrophy
Respiratory Failure

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to Pneumoconiosis

Symptoms & Phenotypes for Pneumoconiosis

GenomeRNAi Phenotypes related to Pneumoconiosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 TNF IL1A IL1B NLRP3 SOD1 TGFB1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 FASLG IL1A IL1B NLRP3 SOD1 TGFB1

MGI Mouse Phenotypes related to Pneumoconiosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 SCGB1A1 SOD1 TGFB1 TNF CAT CP
2 immune system MP:0005387 10.18 CCL2 CP FAS FASLG IL1A IL1B
3 hematopoietic system MP:0005397 10.17 CP FAS FASLG NLRP3 SOD1 TGFB1
4 cellular MP:0005384 10.16 TNF CAT CP FAS FASLG IL6
5 cardiovascular system MP:0005385 10.13 CP FAS FASLG IL1A IL1B IL6
6 integument MP:0010771 9.97 FAS FASLG IL1A IL1B IL6 NLRP3
7 liver/biliary system MP:0005370 9.86 CP FAS FASLG IL6 NLRP3 SOD1
8 neoplasm MP:0002006 9.85 IL1B IL6 SCGB1A1 SOD1 TGFB1 TNF
9 respiratory system MP:0005388 9.5 FAS FASLG IL6 MUC5B SCGB1A1 TGFB1
10 skeleton MP:0005390 9.23 FAS FASLG IL1B IL6 NLRP3 SOD1

Drugs & Therapeutics for Pneumoconiosis

Drugs for Pneumoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2
Deferiprone Approved Phase 4 30652-11-0 2972
3 Liver Extracts Phase 4
4 Micronutrients Phase 4
5 Trace Elements Phase 4
6 Chelating Agents Phase 4
7 Iron Chelating Agents Phase 4
8
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
9
Metoprolol Approved, Investigational Phase 2, Phase 3 37350-58-6, 51384-51-1 4171
10
Isoniazid Approved Phase 3 54-85-3 3767
11
Rifampin Approved Phase 3 13292-46-1 5458213 5381226
12
Rifapentine Approved Phase 3 61379-65-5 6323497
13 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
14 Adrenergic Agents Phase 2, Phase 3
15 Adrenergic Antagonists Phase 2, Phase 3
16 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
17 Adrenergic beta-Antagonists Phase 2, Phase 3
18 Anti-Arrhythmia Agents Phase 2, Phase 3
19 Antihypertensive Agents Phase 2, Phase 3
20 Autonomic Agents Phase 2, Phase 3
21 calcium channel blockers Phase 2, Phase 3
22 Calcium, Dietary Phase 2, Phase 3
23 Neurotransmitter Agents Phase 2, Phase 3
24 Sympatholytics Phase 2, Phase 3
25 Vasodilator Agents Phase 2, Phase 3
26 Anti-Bacterial Agents Phase 3
27 Antibiotics, Antitubercular Phase 3
28 Anti-Infective Agents Phase 3
29 Antimetabolites Phase 3
30 Antitubercular Agents Phase 3
31 Cytochrome P-450 CYP3A Inducers Phase 3
32 Hypolipidemic Agents Phase 3
33 Lipid Regulating Agents Phase 3
34 Nucleic Acid Synthesis Inhibitors Phase 3
35
Infliximab Approved Phase 1, Phase 2 170277-31-3
36 Mitogens Phase 1, Phase 2
37 Analgesics Phase 1, Phase 2
38 Analgesics, Non-Narcotic Phase 1, Phase 2
39 Anti-Inflammatory Agents Phase 1, Phase 2
40 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
41 Antirheumatic Agents Phase 1, Phase 2
42 Mesalamine Phase 1, Phase 2 89-57-6
43 Dermatologic Agents Phase 1, Phase 2
44 Gastrointestinal Agents Phase 1, Phase 2
45
Heparin Approved, Investigational 9005-49-6 772 46507594
46 Respiratory System Agents
47 calcium heparin
48 Pharmaceutical Solutions
49 Xenon Early Phase 1

Interventional clinical trials:

(show all 25)
id Name Status NCT ID Phase
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Active, not recruiting NCT01284127 Phase 4
3 Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome Recruiting NCT02408172 Phase 2, Phase 3
4 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Recruiting NCT02430259 Phase 3
5 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
6 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2
7 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2
8 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
9 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Recruiting NCT02668068 Phase 1
10 Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Not yet recruiting NCT02790762 Phase 1
11 Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis Unknown status NCT02280343
12 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
13 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
14 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
15 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
16 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
17 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
18 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
19 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
20 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Recruiting NCT02794701
21 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693
22 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Recruiting NCT02596347
23 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Recruiting NCT02527330
24 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
25 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1

Search NIH Clinical Center for Pneumoconiosis

Cochrane evidence based reviews: pneumoconiosis

Genetic Tests for Pneumoconiosis

Anatomical Context for Pneumoconiosis

MalaCards organs/tissues related to Pneumoconiosis:

39
Lung, Testes, Monocytes, Neutrophil, Skin, Eye, Liver

Publications for Pneumoconiosis

Articles related to Pneumoconiosis:

(show top 50) (show all 613)
id Title Authors Year
1
Association between Genetic Variants of Transforming Growth Factor-I^1 and Susceptibility of Pneumoconiosis: A Meta-analysis. ( 28139521 )
2017
2
Platelet Indices in Patients with Coal Workers' Pneumoconiosis. ( 27107875 )
2016
3
Estimates and Predictions of Coal Workers' Pneumoconiosis Cases among Redeployed Coal Workers of the Fuxin Mining Industry Group in China: A Historical Cohort Study. ( 26845337 )
2016
4
Aluminum-induced pneumoconiosis confirmed by analytical scanning electron microscopy: A case report and review of the literature. ( 26895029 )
2016
5
Coal workers' pneumoconiosis: an Australian perspective. ( 27318401 )
2016
6
Pneumoconiosis Redux. Coal Workers' Pneumoconiosis and Silicosis Are Still a Problem. ( 26977968 )
2016
7
Dental technician pneumoconiosis mimicking pulmonary tuberculosis: a case report. ( 27604085 )
2016
8
The relation between the extent of radiological findings and respiratory functions in pneumoconiosis cases of dental technicians who are working in Ankara. ( 27481079 )
2016
9
Screening and Preliminary Verification of a Phage Display Single-Chain Antibody Library Against Coal Workers' Pneumoconiosis. ( 27930489 )
2016
10
Ocular findings in coal miners diagnosed with pneumoconiosis. ( 27292375 )
2016
11
Ocular findings in coal miners diagnosed with pneumoconiosis. ( 27406957 )
2016
12
Risk factors associated with mortality from pneumonia among patients with pneumoconiosis. ( 27057317 )
2016
13
Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers' Pneumoconiosis in a Chinese Population. ( 27626436 )
2016
14
Emphysema and Airflow Obstruction in Non-Smoking Coal Miners with Pneumoconiosis. ( 27956734 )
2016
15
Endogenous pneumoconiosis: Analytical scanning electron microscopic analysis of a case. ( 27281119 )
2016
16
Socio-Demographic and Clinical Characteristics of Turkish Workers with Pneumoconiosis. ( 27755862 )
2016
17
Risk of Cerebrovascular Events in Pneumoconiosis Patients: A Population-based Study, 1996-2011. ( 26945404 )
2016
18
Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population. ( 27621877 )
2016
19
Plasma LncRNA-ATB, a Potential Biomarker for Diagnosis of Patients with Coal Workers' Pneumoconiosis: A Case-Control Study. ( 27556453 )
2016
20
Japanese Workplace Health Management in Pneumoconiosis Prevention. ( 27980247 )
2016
21
Endobronchial fibroma in a pneumoconiosis patient with a history of tuberculosis: A case report and literature review. ( 27446391 )
2016
22
Differential gene expression associated with inflammation in peripheral blood cells of patients with pneumoconiosis. ( 27265534 )
2016
23
Pneumoconiosis increases the risk of congestive heart failure: A nationwide population-based cohort study. ( 27336897 )
2016
24
Lung transplantation is increasingly common among patients with coal workers' pneumoconiosis. ( 26725917 )
2016
25
Pneumoconiosis increases the risk of peripheral arterial disease: a nationwide population-based study. ( 26020403 )
2015
26
Association between pneumoconiosis and pulmonary emboli. A Nationwide Population-Based Study in Taiwan. ( 25588465 )
2015
27
Lung Pathology in U.S. Coal Workers with Rapidly Progressive Pneumoconiosis Implicates Silica and Silicates. ( 26513613 )
2015
28
A coal worker's pneumoconiosis diagnosed with endosonography. ( 25841573 )
2015
29
Cost-Effectiveness of Coal Workers' Pneumoconiosis Prevention Based on Its Predicted Incidence within the Datong Coal Mine Group in China. ( 26098706 )
2015
30
The association between bronchial anthracofibrosis and pneumoconiosis: A retrospective cross-sectional study. ( 25519805 )
2015
31
Dental technician pneumoconiosis mimicking lung cancer. ( 26369493 )
2015
32
Case cluster of pneumoconiosis at a coal slag processing facility. ( 25851166 )
2015
33
Associations of MMP1, MMP2 and MMP3 Genes Polymorphism with Coal Workers' Pneumoconiosis in Chinese Han Population. ( 26528997 )
2015
34
Comparison of the Cumulative Incidence Rates of Coal Workers' Pneumoconiosis between 1970 and 2013 among Four State-Owned Colliery Groups in China. ( 26133134 )
2015
35
Epidemiological analysis of pneumoconiosis in the Xinjiang Uygur Autonomous Region and cases reported by the Urumqi Railway Bureau. ( 25867304 )
2015
36
Relationships (I) of International Classification of High-resolution Computed Tomography for Occupational and Environmental Respiratory Diseases with the ILO International Classification of Radiographs of Pneumoconiosis for parenchymal abnormalities. ( 25810444 )
2015
37
Profusion of Opacities in Simple Coal Worker's Pneumoconiosis Is Associated With Reduced Lung Function. ( 25996896 )
2015
38
Primary pleural angiosarcoma associated with pneumoconiosis: An autopsy case. ( 26314557 )
2015
39
Serum levels of IL-8 and ICAM-1 as biomarkers for progressive massive fibrosis in coal workers' pneumoconiosis. ( 25653483 )
2015
40
Prevalence Characteristics of Coal Workers' Pneumoconiosis (CWP) in a State-Owned Mine in Eastern China. ( 26184259 )
2015
41
Patterns of pneumoconiosis mortality in Kentucky: Analysis of death certificate data. ( 26374490 )
2015
42
CT patterns of pleuro-pulmonary damage caused by inhalation of pumice as a model of pneumoconiosis from non-fibrous amorphous silicates. ( 26231253 )
2015
43
Increased risk of ischemic stroke in patients with pneumoconiosis. ( 25497706 )
2015
44
Polymorphisms in interleukin 17A gene and coal workers' pneumoconiosis risk in a Chinese population. ( 26223249 )
2015
45
Underground Coal Mining: Relationship between Coal Dust Levels and Pneumoconiosis, in Two Regions of Colombia, 2014. ( 26366418 )
2015
46
Fifty years ago: 'Emery Pneumoconiosis'. ( 26503973 )
2015
47
Associations of MMP-7 and OPN gene polymorphisms with risk of coal workers' pneumoconiosis in a Chinese population: a case-control study. ( 26330178 )
2015
48
Analysis of mutational characteristics of the drug-resistant gene katG in multi-drug resistant Mycobacterium tuberculosis L-form among patients with pneumoconiosis complicated with tuberculosis. ( 24626681 )
2014
49
"Samosa" pneumoconiosis: a case of pulmonary talcosis uncovered during a medicolegal autopsy. ( 24457575 )
2014
50
Pathway analysis for a genome-wide association study of pneumoconiosis. ( 25445010 )
2014

Variations for Pneumoconiosis

Expression for Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for Pneumoconiosis

Pathways related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 CAT CCL2 CXCL8 FASLG IL1A IL1B
2
Show member pathways
13.71 CCL2 CXCL8 FAS FASLG IL1A IL1B
3
Show member pathways
13.55 CXCL8 FAS FASLG IL1A IL1B IL6
4
Show member pathways
13.48 CCL2 CXCL8 FAS FASLG IL1A IL1B
5
Show member pathways
13.42 CCL2 CXCL8 FASLG IL1A IL1B IL6
6
Show member pathways
13.37 CCL2 CXCL8 FAS FASLG IL1A IL1B
7
Show member pathways
13.18 CAT CXCL8 HSPA1L IL1A IL6 SOD1
8
Show member pathways
13.04 CCL2 CP CXCL8 IL1A IL1B IL6
9
Show member pathways
12.96 CCL2 CXCL8 FAS FASLG IL1B IL6
10
Show member pathways
12.93 CCL2 FAS FASLG IL6 TNF
11
Show member pathways
12.89 CXCL8 FAS FASLG HSPA1L IL1A IL1B
12 12.78 FAS FASLG HSPA1L IL1A IL1B TGFB1
13
Show member pathways
12.75 IL1A IL1B IL6 TGFB1 TNF
14 12.73 CXCL8 FAS FASLG IL6 TGFB1
15
Show member pathways
12.72 FAS FASLG IL1A IL1B TNF
16
Show member pathways
12.67 FAS FASLG IL1A IL1B TNF
17
Show member pathways
12.66 IL1A IL1B IL6 TGFB1 TNF
18
Show member pathways
12.65 CCL2 CXCL8 FAS FASLG HSPA1L IL1A
19 12.61 CCL2 FAS FASLG IL1B TNF
20
Show member pathways
12.53 FAS IL1A IL1B IL6 TGFB1 TNF
21
Show member pathways
12.41 CAT CCL2 IL1B IL6 SOD1 TNF
22
Show member pathways
12.4 CCL2 CXCL8 IL1B IL6 MUC5B TNF
23
Show member pathways
12.36 CXCL8 IL1A IL1B IL6 TNF
24 12.35 FAS FASLG TGFB1 TNF
25
Show member pathways
12.35 HSPA1L IL1A IL1B TGFB1 TNF
26
Show member pathways
12.32 CXCL8 IL1A IL6 TNF
27 12.32 IL1A IL1B IL6 TGFB1 TNF
28
Show member pathways
12.31 FAS FASLG IL1A TNF
29 12.28 CXCL8 IL1A IL1B IL6 TNF
30
Show member pathways
12.27 CXCL8 FAS FASLG IL1B IL6 TNF
31
Show member pathways
12.25 CXCL8 IL1A IL1B IL6 TNF
32 12.2 CCL2 GSTM1 IL1A IL1B TNF
33
Show member pathways
12.16 CAT FASLG IL6 TGFB1
34 12.14 FAS IL6 TGFB1 TNF
35 12.12 IL1A IL1B TGFB1 TNF
36 12.06 CCL2 FAS IL1B IL6 TNF
37 12.06 CCL2 CXCL8 IL1A IL1B IL6 TGFB1
38 12.04 CXCL8 IL1A IL1B IL6 TGFB1
39
Show member pathways
12.03 IL1B IL6 TGFB1 TNF
40 11.99 IL1A IL1B IL6 TNF
41 11.99 CXCL8 IL1B IL6 TGFB1 TNF
42 11.93 CXCL8 IL1A IL1B IL6
43 11.91 CXCL8 IL1B TNF
44
Show member pathways
11.9 CXCL8 IL6 TGFB1
45 11.87 IL1B IL6 TGFB1 TNF
46
Show member pathways
11.86 FAS FASLG TNF
47 11.86 CCL2 CXCL8 IL1A IL1B IL6 TGFB1
48
Show member pathways
11.81 CXCL8 FASLG TNF
49 11.81 CXCL8 IL1A IL1B IL6 NLRP3 TNF
50 11.79 FAS FASLG GSTM1

GO Terms for Pneumoconiosis

Cellular components related to Pneumoconiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 CAT CCL2 CP CXCL8 FASLG IL1A
2 external side of plasma membrane GO:0009897 9.56 FAS FASLG IL6 TNF
3 extracellular region GO:0005576 9.5 CAT CCL2 CP CXCL8 FAS FASLG
4 secretory granule GO:0030141 9.46 IL1B SCGB1A1 SOD1 TGFB1

Biological processes related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.99 CCL2 IL6 TGFB1 TNF
2 positive regulation of protein phosphorylation GO:0001934 9.97 FAS IL1B TGFB1 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.96 CCL2 IL1A IL1B IL6
4 aging GO:0007568 9.95 CAT CCL2 IL6 SOD1 TGFB1
5 positive regulation of protein kinase B signaling GO:0051897 9.91 IL6 TGFB1 TNF
6 response to wounding GO:0009611 9.9 CCL2 IL6 TGFB1
7 cellular response to mechanical stimulus GO:0071260 9.9 FAS IL1B TGFB1
8 cellular response to interleukin-1 GO:0071347 9.9 CCL2 CXCL8 IL6
9 apoptotic signaling pathway GO:0097190 9.89 FAS FASLG TNF
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.89 IL6 TGFB1 TNF
11 neutrophil chemotaxis GO:0030593 9.88 CCL2 CXCL8 IL1B
12 response to organic substance GO:0010033 9.88 SCGB1A1 SOD1 TGFB1 TNF
13 cellular response to lipopolysaccharide GO:0071222 9.88 CCL2 CXCL8 IL6 NLRP3 TNF
14 humoral immune response GO:0006959 9.87 CCL2 IL6 TNF
15 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.87 FAS FASLG NLRP3 TNF
16 response to heat GO:0009408 9.86 CCL2 IL6 SOD1
17 cellular response to organic cyclic compound GO:0071407 9.86 CCL2 IL1B TGFB1 TNF
18 embryo implantation GO:0007566 9.85 IL1B SCGB1A1 SOD1
19 negative regulation of fat cell differentiation GO:0045599 9.85 IL6 TGFB1 TNF
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 IL1B IL6 TNF
21 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.81 IL1A IL1B TNF
22 positive regulation of cell division GO:0051781 9.81 CAT IL1A IL1B TGFB1
23 positive regulation of interleukin-6 production GO:0032755 9.8 IL1A IL1B IL6 TNF
24 response to lipopolysaccharide GO:0032496 9.8 CCL2 FAS FASLG IL1B IL6 SCGB1A1
25 cellular response to dexamethasone stimulus GO:0071549 9.79 CCL2 IL6 TGFB1
26 response to antibiotic GO:0046677 9.78 CCL2 IL6 SOD1
27 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.77 FAS FASLG TNF
28 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.77 FAS IL1A IL1B
29 positive regulation of vascular endothelial growth factor production GO:0010575 9.76 IL1A IL1B TGFB1
30 extrinsic apoptotic signaling pathway GO:0097191 9.76 FAS FASLG TGFB1 TNF
31 immune response GO:0006955 9.76 CCL2 CXCL8 FAS FASLG IL1A IL1B
32 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.74 IL1B TNF
33 cellular response to ATP GO:0071318 9.74 CCL2 SOD1
34 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.74 FAS FASLG
35 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.74 IL1B TNF
36 PERK-mediated unfolded protein response GO:0036499 9.73 CCL2 CXCL8
37 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.73 IL1A IL1B
38 positive regulation of superoxide anion generation GO:0032930 9.73 SOD1 TGFB1
39 positive regulation of chemokine biosynthetic process GO:0045080 9.73 IL1B TNF
40 myeloid cell homeostasis GO:0002262 9.73 IL6 SOD1
41 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF
42 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.71 IL1A IL1B
43 positive regulation of T-helper 2 cell differentiation GO:0045630 9.71 IL6 NLRP3
44 ectopic germ cell programmed cell death GO:0035234 9.71 IL1A IL1B
45 protein kinase B signaling GO:0043491 9.71 CCL2 IL1B TGFB1 TNF
46 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
47 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.69 IL6 TNF
48 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.69 IL6 NLRP3
49 response to ozone GO:0010193 9.68 CAT SCGB1A1
50 regulation of vascular endothelial growth factor production GO:0010574 9.68 CCL2 IL6

Molecular functions related to Pneumoconiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL2 CXCL8 FASLG IL1A IL1B IL6
2 copper ion binding GO:0005507 9.13 CP IL1A SOD1

Sources for Pneumoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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