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Pneumoconiosis malady
51 genes, 2 tissues, 890 related diseases, 22 phenotypes, 35 articles, clinical trials.

Summaries for Pneumoconiosis

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6Disease Ontology, 44Wikipedia, 22MalaCards
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Wikipedia: Pneumoconiosis is an occupational lung disease and a restrictive lung disease caused by the inhalation...44 more...

MalaCards: Pneumoconiosis, also known as pneumoconiosis nos (disorder), is related to anthracosis and silicosis. An important gene associated with Pneumoconiosis is SOD1 (superoxide dismutase 1, soluble), and among its related pathways are Bacterial infections in CF airways and Graft-versus-host disease. The compounds egcg and ivig have been mentioned in the context of this disorder. Affiliated tissues include lung and t cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Disease Ontology: An interstitial lung disease that is caused by the inhalation of dust.6

Aliases & Descriptions for Pneumoconiosis

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 19ICD9CM, 24MeSH, 27NCIt
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Aliases & Descriptions:

pneumoconiosis 6 8 32 43
pneumoconiosis nos (disorder) 6
pneumoconiosis, unspecified 6
pneumoconiosis (disorder) 6
pneumoconiosis nos 6
pneumoconioses 6

Related Diseases for Pneumoconiosis

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13GeneCards, 14GeneDecks
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Diseases related to pneumoconiosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 887)
idRelated DiseaseScoreTop Affiliating Genes
1anthracosis32.7BMP6, CCL2, SOD1
2silicosis26.0SCGB1A1, JUN, IL1A, IL1B, IL1RN, IL6
3fibrosis16.4SFTPA1, SERPINE1, BMP6, BCL2, SCGB1A1, FTL
4endemic goiter13.8BMP6, CAT, SOD1, CP
5diabetic cataract13.7CAT, SOD1, CP
6hemosiderosis13.7FTH1, FTL, CAT, CP
7aceruloplasminemia13.7SOD1, SOD2, CP
8nutritional deficiency disease13.7FTH1, FTL, TFRC
9berger disease13.7BMP6, SCGB1A1, MBL2
10avascular necrosis of femoral head13.6CAT, HLA-DRB1, SOD1
11siderosis13.6FTH1, TFRC, CP
12hiv infection, susceptibility/resistance to13.6CCR2, CCR5
13hiv-1, resistance to13.6CCR2, CCL2, CCR5
14drug-induced hepatitis13.6GSTM1, GSTT1, CAT, CP
15exfoliation syndrome13.6GSTM1, GSTT1, CAT, SOD1
16senile cataract13.6GSTM1, GSTT1, CAT, SOD1
17erdheim-chester disease13.5IL1B, CCL2, CCR5
18lumbar disc degeneration13.5MMP3, FASLG, FAS
19peyronies disease13.5BMP6, CCL2, TGFB1, SOD1
20mitochondrial encephalomyopathy13.5CAT, SOD1, SOD2, CP
21abdominal aortic aneurysm13.5MMP3, CCL2, TNFRSF1B, PLAU
22ureteral disease13.5FN1, CCL2, TGFB1
23htlv-1 associated myelopathy/tropical spastic paraparesis13.5JUN, FASLG, CX3CR1
24retinal vasculitis13.5TNF, CX3CR1, SOD1
25diabetic foot ulcers13.5HSPA1B, HSPA1L, TGFB1, SOD1
26gastric cancer risk after h. pylori infection13.4IL1B, IL1RN
27hypersensitivity reaction type iv disease13.4FN1, IL2RB, IL4
28ulceration of vulva13.4FN1, IL2RB, CCR5, HSPA1A, CP
29multinodular goiter13.4IL1A, IL1B, CAT, SOD1, CP
30syphilis13.4FN1, CCR5, HLA-DRB1, CP
31encephalomyopathy13.4CAT, SOD1, SOD2, CP
32tuberculoid leprosy13.4HSPA1A, TNF
33rheumatoid arthritis13.4IL1RN, MBL2, HLA-DRB1
34acute myocarditis13.4FASLG, FAS, PLAT
35alcoholic pancreatitis13.4GSTM1, GSTT1, CAT, SOD2
36chronic rapidly progressive glomerulonephritis13.4SERPINE1, SCGB1A1, FN1
37digestive diseases13.4CAT, ERBB2, SOD1
38cryptosporidiosis13.4IL1A, IL4, MBL2, CAT
39central serous chorioretinopathy13.4SERPINE1, PLAT
40pelvic inflammatory disease13.4CCL2, HLA-DQB1, PLAT, PLAU
41hypofibrinogenemia13.4SERPINE1, PLAT, CP
42somatoform disorder13.4IL1A, IL1B, IL1RN
43t-lymphocytopenia13.4IL2RB, IL4, FAS
44severe congenital neutropenia13.4HSPA1A, HSPA1B, CAT, HLA-DQB1, HLA-DRB1
45malignant histiocytosis13.3IL1A, IL1B, TFRC
46tardive dyskinesia13.3GSTM1, GSTT1, CAT, SOD1, SOD2
47plasminogen activator deficiency13.3SERPINE1, PLAT, PLAU
48autoimmune lymphoproliferative syndrome13.3FASLG, FAS, CASP8
49sympathetic ophthalmia13.3CCL2, HLA-DRB1, TNF
50proliferative vitreoretinopathy13.3BMP6, FN1, CCL2, TGFB1, TFRC

Graphical network of the top 20 diseases related to pneumoconiosis:



Graphical network of diseases related to pneumoconiosis

Clinical Features for Pneumoconiosis

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Drugs & Therapeutics for Pneumoconiosis

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pneumoconiosis

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Anatomical Context for Pneumoconiosis

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22MalaCards
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MalaCards organs/tissues related to pneumoconiosis:

22
Lung, T cells

Phenotypes for genes affiliated with Pneumoconiosis

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25MGI
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MGI Mouse Phenotypes related to pneumoconiosis:

25 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.5CCR2, SCGB1A1
2endocrine/exocrine gland phenotypeMP:00053799.9CASP8, FASLG, IL2RB, SGOL2
3renal/urinary system phenotypeMP:00053679.8SOD2, TNFRSF1B, SCGB1A1, BCL2
4hematopoietic system phenotypeMP:00053979.5BCL2, FTH1, CCR2, HLA-DQB1, TFRC, CX3CR1
5liver/biliary system phenotypeMP:00053709.0FTH1, IL6, CCR2, CCR5, TP53, SOD1
6pigmentation phenotypeMP:00011868.8SOD2, CX3CR1, TP53, CCL2, CCR2, FAS
7nervous system phenotypeMP:00036318.6FTH1, FASLG, CCR2, HSPA1A, HSPA4, CASP8
8digestive/alimentary phenotypeMP:00053818.4CX3CR1, TFRC, TGFB1, PLAU, PLAT, ERBB2
9integument phenotypeMP:00107717.9CX3CR1, TNFRSF1B, TP53, ERBB2, CASP8, FAS
10immune system phenotypeMP:00053877.7FTH1, MMP3, FN1, IL6, MBL2, SOD2
11skeleton phenotypeMP:00053907.3TP53, TNFRSF1B, PLAT, PLAU, ERBB2, FAS
12behavior/neurological phenotypeMP:00053867.3HLA-DQB1, TNFRSF1B, PLAT, CX3CR1, SOD2, CP
13reproductive system phenotypeMP:00053897.3CCR5, ERBB2, TNF, TGFB1, SOD2, CCL2
14adipose tissue phenotypeMP:00053757.2SOD2, TGFB1, PLAU, TNFRSF1B, TNF, TP53
15mortality/agingMP:00107686.7HSPA4, CAT, HLA-DQB1, TP53, PLAT, PLAU
16vision/eye phenotypeMP:00053916.2TNFRSF1B, PLAT, PLAU, TGFB1, CX3CR1, SOD1
17growth/size phenotypeMP:00053786.1CASP8, ERBB2, TP53, PLAT, PLAU, TFRC
18muscle phenotypeMP:00053696.0TNFRSF1B, PLAT, PLAU, TGFB1, CX3CR1, SOD1
19tumorigenesisMP:00020065.4FN1, IL1A, IL1B, IL6, FASLG, FAS
20homeostasis/metabolism phenotypeMP:00053764.3SERPINE1, ERBB2, HLA-DQB1, TP53, TNFRSF1B, PLAT
21cardiovascular system phenotypeMP:00053853.9IL1RN, IL6, FASLG, FAS, CCR2, CCL2
22cellular phenotypeMP:00053843.3SOD2, CP, SOD1, CX3CR1, CCL2, CCR5

Publications for genes affiliated with Pneumoconiosis

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35PubMed
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Articles related to pneumoconiosis:

(show all 35)
idTitleAuthorsYearAffiliating Genes
1Associations of IL-4, IL-4R, and IL-13 gene polymorph isms in coal workers' pneumoconiosis in China: a case-control study. (21857939)Wang M.... Ni C.2011IL4
2Polymorphisms in heat-shock protein 70 genes are asso ciated with coal workers' pneumoconiosis in southwestern China. (21471543)Zhang H.... Li Q.Q.2011HSPA1B
3Effect of HSP70 gene polymorphism on genetic suscept ibility of pneumoconiosis of coal worker]. (20568452)Zhou F.... Wu Y.2010HSPA1A, HSPA1B, HSPA1L
4Common genetic variants in pre-microRNAs are associat ed with risk of coal workers' pneumoconiosis. (19881472)Wang M.... Ni C.2010MIR146A, MIR196A2, MIR149
5Possible effect of gene polymorphisms on the release of TNFalpha and IL1 cytokines in coal workers' pneumoconiosis. (20005085)Ates I.... Karakaya A.2009TNF, IL1B, IL1A
6Transforming growth factor beta and tumor necrosis f actor gene polymorphism and coal worker's pneumoconiosis (19493496)Yu C.... Qi F.2009TGFB1, TNF, BMP6
7A six-nucleotide insertion-deletion polymorphism in t he CASP8 promoter is associated with risk of coal workers' pneumoconiosis. (19492233)Ni C.... Zhou J.2009CASP8
8Relationship between gene polymorphism of fibronectin and Pneumoconiosis. (19224684)Fan X.Y.... Cao Y.2009FN1
9Mannose-binding lectin gene polymorphisms and the development of coal workers' pneumoconiosis in Japan. (18496832)Wang X.... Munakata M.2008MBL2
10Relationship between gene polymorphism of transforming growth factor-beta and pneumoconiosis (17374177)Fan X.Y.... Zhang S.J.2007TGFB1
11Activity of superoxide dismutase and level of lipid peroxidation in pneumoconiosis patients (17908436)Zhang F.C.... Yang X.H.2007SOD1
12Relationship between FAS/FASL gene polymorphisms and susceptibility of coal worker's pneumoconiosis (17997887)Ni C.H.... Zhou J.W.2007FAS, FASLG
13Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker's pneumoconiosis: a comprehensive review. (16990219)Gulumian M.... Murray J.2006IL8, SCGB1A1
14Changes of tumor necrosis factor, surfactant protein A, and phospholipids in bronchoalveolar lavage fluid in the development and progression of coal workers' pneumoconiosis. (16827183)Xing J.C.... Bruch J.2006TNF, SFTPA1
15Polymorphisms in chemokine and chemokine receptor genes and the development of coal workers' pneumoconiosis. (16524739)Nadif R.... Kleeberger S.R.2006CCR5, CCL2, CCR2
16Gene polymorphisms of fibrinolytic enzymes in coal workers' pneumoconiosis. (17649957)Chang L.C.... Wu H.P.2006PLAU, PLAT, SERPINE1
17Significance of serum sialic acid and ceruloplasmin in early lung fibrosis of pneumoconiosis (16600124)Lou K.J.2006CP
18Relationship between genetic polymorphism of interleukin-6 and pneumoconiosis (17034727)Liu Y.H.... Wang L.Q.2006IL6
19Relationship between polymorphism of interleukin-1 and pneumoconiosis susceptibility (17034724)Fan X.Y.... Yao S.Q.2006IL1B, IL1A, IL1RN
20Antithetical effect of tumor necrosis factor-alphagene polymorphism on coal workers' pneumoconiosis (CWP). (15940715)Wang X.T.... Munakata M.2005TNF
21Oxidative injury and serum cytokines in coal workers with pneumoconiosis (16078574)Yao W.... Wang N.2005SOD1
22Relationship between pneumoconiosis and the polymorphisms of HLA-DRB1*, DQB1* genes (16188098)Fan X.Y.... Ma Q.K.2005HLA-DQB1, HLA-DRB1
23The presence of promatrix metalloproteinase-3 and its relation with different categories of coal workers' pneumoconiosis. (15203551)Altin R.... Ornek T.2004MMP3
24Antioxidant response at early stages and low grades of simple coal worker's pneumoconiosis diagnosed by high resolution computed tomography. (15575561)Altin R.... Ozdemir H.2004SOD1
25Potential effect of tumor necrosis factor-alpha and its receptor II gene polymorphisms on the pathogenesis of coal worker's pneumoconiosis (15355698)Li L.... Wang H.L.2004TNF, TNFRSF1B
26Gene expression of primary human bronchial epithelial cells in response to coal dusts with different prevalence of coal workers' pneumoconiosis. (12851122)Hu W.... Huang X.2003TFRC
27Study on the expression of C-erbB-2 gene in coal miners with pneumoconiosis complicated by pulmonary cancer (14761474)Peng J.H.... Sun J.2003ERBB2
28Tumor necrosis factor-alpha gene promoter polymorphism in coal workers' pneumoconiosis. (12162435)Kim K.A.... Lim Y.2002TNF
29Genetic polymorphisms of MnSOD, GSTM1, GSTT1, and OGG1 in coal workers' pneumoconiosis. (11977425)Zhai R.... Christiani D.C.2002SOD2, OGG1, GSTT1
30Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and their soluble receptors in coal workers' pneumoconiosis. (12412984)Zhai R.... Liang D.2002IL2RB
31p53 and Bcl-2 expression in pneumoconiosis-related pre-cancerous lesions and lung cancers: frequent and preferential p53 expression in pneumoconiotic bronchiolar dysplasias. (9466648)Katabami M.... Kikuchi K.1998TP53, BCL2
32Buffering capacity of coal and its acid-soluble Fe2+ content: possible role in coal workers' pneumoconiosis. (9671534)Huang X.... Chen L.C.1998JUN
33MCP-1 secretion in lung from nonsmoking patients with coal worker's pneumoconiosis. (9072984)Boitelle A.... Tonnel A.B.1997CCL2
34Hydroxyl radical generation by coal mine dust: possible implication to coal workers' pneumoconiosis (CWP). (7896164)Dalal N.S.... Vallyathan V.1995SOD1, CAT
35Mechanisms of fibrosis in coal workers' pneumoconiosis. Increased production of platelet-derived growth factor, insulin-like growth factor type I, and transforming growth factor beta and relationship to disease severity. (7921435)Vanhee D.... Tonnel A.B.1994BMP6

Expression for genes affiliated with Pneumoconiosis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Pneumoconiosis

Pathways for genes affiliated with Pneumoconiosis

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41Thomson Reuters, 20KEGG, 37R&D Systems, 36QIAGEN, 10EMD Millipore
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Pathways related to pneumoconiosis according to GeneDecks:

(show top 50)    (show all 133)
idPathwayScoreTop Affiliating Genes
1Bacterial infections in CF airways4110.7SFTPA1
2Graft-versus-host disease2010.5IL1A, FASLG
3IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types3710.1BCL2, IL2RB, FASLG
4Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)419.8CP, HSPA1L, HSPA1B, SOD1, HSPA4, HSPA1A
5IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types379.6IL2RB, FASLG, TNF, FAS, TNFRSF1B, TGFB1
6NFAT Signaling and Lymphocyte Interactions369.6BMP6, BCL2, IL1A, IL2RB, IL4, CCL2
7IL-6 Pathway369.6IL4, BMP6, IL8, CCL2
8Cellular Transformation by HTLV1369.3JUN, TNFRSF1B, TNF, HSPA4, HSPA1B, HSPA1A
9Development Glucocorticoid receptor signaling109.1HSPA4, HSPA1L, HSPA1B, HSPA1A, JUN, SERPINE1
10Antigen processing and presentation209.1HSPA1L, HSPA1B, HSPA1A, HLA-DQB1, HLA-DRB1, HSPA4
11Type I diabetes mellitus209.0FASLG, FAS, IL1A, HLA-DRB1, IL1B, HLA-DQB1
12Allograft rejection209.0FAS, IL4, FASLG, HLA-DRB1, HLA-DQB1, TNF
13Akt Signaling369.0TNF, IL4, CX3CR1, CCR5, CCL2, IL6
14Apoptosis and survival Apoptotic TNF-family pathways108.9FAS, TNF, TNFRSF1B, FASLG, CASP8, BCL2
15PGC1Alpha Pathway368.8IL1B, TNFRSF1B, IL4, IL1A, BCL2, BMP6
16Apoptosis and survival_Apoptotic TNF-family pathways418.7BCL2, FAS, CASP8, TNF, TNFRSF1B, FASLG
17Toxoplasmosis208.6HSPA1B, HSPA1L, CASP8, HLA-DQB1, TNF, TGFB1
18Measles208.6IL2RB, IL1A, IL1B, IL4, IL6, FASLG
19Leishmaniasis208.6HLA-DQB1, JUN, TGFB1, TNF, HLA-DRB1, IL4
20Endothelin-1 Signaling Pathway368.5BMP6, ERBB2, IL6, IL1A, IL1B, IL4
21Apoptosis208.5BCL2, IL1A, IL1B, FASLG, TP53, FAS
22Apoptosis Signaling Pathways378.4FAS, FASLG, TP53, BCL2, HSPA4, CASP8
23Cytokine Network368.2IL8, IL6, IL4, IL1B, IL1A, TNF
24MAPK signaling pathway208.2JUN, TNF, TGFB1, TP53, HSPA1L, HSPA1B
25Pathways in cancer208.2TP53, BCL2, ERBB2, CASP8, FAS, TGFB1
26Immune response IL-1 signaling pathway108.1IL6, IL8, SERPINE1, JUN, CP, TNF
27Immune response_IL-1 signaling pathway418.1CP, TNF, IL8, SERPINE1, JUN, IL1A
28ERK Signaling368.0IL6, TGFB1, FN1, ERBB2, IL4, IL1B
29Pertussis208.0SFTPA1, IL1A, TNF, IL1B, IL6, IL8
30Molecular Mechanisms of Cancer368.0CASP8, TP53, TNFRSF1B, TGFB1, CX3CR1, IL6
31MIF Mediated Glucocorticoid Regulation367.8IL1B, TNF, CCL2, IL8, IL6, BMP6
32all-trans-Retinoic Acid Signaling in Brain367.7IL8, CCL2, BMP6, TNF, IL4, IL1B
33Tuberculosis207.6BCL2, IL1B, TNF, TGFB1, HLA-DRB1, HLA-DQB1
34Rho Family GTPases367.5ERBB2, CCL2, IL4, IL1B, TGFB1, BMP6
35PEDF Induced Signaling367.5SOD2, TNF, CASP8, IL8, BMP6, BCL2
36Rheumatoid arthritis207.4MMP3, JUN, IL1A, IL1B, IL6, IL8
37Chagas disease (American trypanosomiasis)207.4CCL2, CASP8, TNF, FAS, FASLG, IL8
38TGF-Beta Pathway367.3BMP6, JUN, IL1A, IL1B, IL2RB, IL4
39PAK Pathway367.2TGFB1, IL1A, CCL2, BMP6, IL1B, IL4
40STAT3 Pathway367.2IL8, CCR2, CCL2, CCR5, TNF, TNFRSF1B
41MIF Regulation of Innate Immune Cells367.1BMP6, TNF, BCL2, JUN, IL1A, IL1B
42Tec Kinases Signaling367.1TGFB1, BMP6, BCL2, IL2RB, IL4, IL6
43Glucocorticoid Receptor Signaling367.1TGFB1, TNFRSF1B, HSPA1B, HSPA1A, CCL2, IL8
44Influenza A207.1JUN, TNF, IL1A, IL1B, IL6, IL8
45MAPK Family Pathway367.0IL8, BMP6, BCL2, JUN, IL1A, CCL2
46Cytokine-cytokine receptor interaction207.0CCR2, FAS, FASLG, IL8, IL6, IL4
47JAK-STAT Pathway366.6IL2RB, BMP6, BCL2, JUN, ERBB2, TNFRSF1B
48MAPK Signaling366.6BMP6, BCL2, JUN, IL1A, FN1, TGFB1
49Antioxidant Action of Vitamin-C366.6IL1A, IL1B, JUN, IL8, CX3CR1, BCL2
50p38 Signaling365.8BMP6, BCL2, IL1A, IL1B, IL2RB, IL4

Compounds for genes affiliated with Pneumoconiosis

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32Novoseek , 42Tocris Bioscience, 18HMDB, 9DrugBank, 34PharmGKB
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Compounds related to pneumoconiosis according to GeneDecks:

(show top 50)    (show all 363)
idCompoundScoreTop Affiliating Genes
1egcg32 10.6IL1A, CAT, SOD1
2ivig32 10.5CCR5, FASLG
3sp 60012532 42 11.5TP53
4endotoxin32 10.2HSPA1A, FASLG, IL2RB, SCGB1A1, TNFRSF1B
5sodium nitroprusside32 9.9TFRC, CAT, HSPA4, FASLG, BMP6, CP
6h2o232 9.9HSPA1A, IL1RN, FTL, FTH1, TNFRSF1B, OGG1
7pge232 9.7PLAU, TNFRSF1B, FASLG, IL1RN, IL1A, FN1
8n acetylcysteine32 9.4PLAU, TP53, ERBB2, IL2RB, MMP3
9estrogen32 9.2SERPINE1, SCGB1A1, MMP3, IL1RN, CP, ERBB2
10aspartate32 9.2BMP6, SOD2, PLAU, HLA-DQB1, ERBB2, MBL2
11ascorbic acid32 18 9.8SOD2, OGG1, TFRC, HSPA4, FAS, FASLG
12mg 13232 42 9.4JUN, IL1A, IL1B, HSPA4, HSPA1A, FAS
13sb 20358032 42 9.3PLAU, TNF, CASP8, HSPA4, IL6, MMP3
14mip 1alpha32 8.1PLAU, TNF, CCR5, CCL2, IL8, IL6
15tgf beta132 8.1FN1, MMP3, BMP6, SERPINE1, IL1RN, IL6
16gm-csf32 8.0BMP6, IL1A, TGFB1, TNF, CCL2, IL8
17nitric oxide32 9 18 9 10.8IL1RN, IL1B, IL1A, SCGB1A1, BMP6, IL2RB
18polymyxin b32 7.7CCL2, MBL2, IL8, IL6, IL4, IL1RN
19neopterin32 7.7TFRC, TNFRSF1B, TNF, MBL2, IL8, IL6
20oxygen32 18 8.7HSPA1A, MBL2, FAS, IL2RB, GSTT1, GSTM1
21arginine32 7.6CASP8, HSPA1A, CCR5, CCL2, IL2RB, IL1A
22creatinine32 7.5CP, SOD2, TFRC, TGFB1, PLAU, HSPA4
23cyclosporin a32 42 8.5SOD2, FN1, MMP3, JUN, IL1A, IL1RN
24rantes32 7.4CX3CR1, TGFB1, TNFRSF1B, CCR5, CCL2, MBL2
25adriamycin32 7.4SOD1, BCL2, FN1, FASLG, OGG1, TFRC
26il 1032 7.3CCL2, IL8, IL6, IL4, IL2RB, IL1RN
27simvastatin32 34 42 9 18 9 12.3MMP3, BMP6, SERPINE1, IL1A, IL1RN, IL4
28triptolide32 7.1PLAU, BCL2, JUN, TNF, TP53, CASP8
29arsenite32 18 8.0CAT, HSPA4, HSPA1A, FAS, FASLG, JUN
30troglitazone32 42 9 9 9.9PLAT, TNF, CASP8, CCL2, IL8, IL6
31methotrexate32 34 42 9 9 10.8FASLG, IL6, IL2RB, IL1RN, IL1B, GSTM1
3215-deoxy-delta-12,14-prostaglandin j232 6.8JUN, BMP6, SERPINE1, IL1B, IL4, IL6
33ly29400232 6.7IL6, IL4, IL1B, FN1, JUN, IL8
34doxorubicin32 34 9 9 9.5SOD2, TFRC, TGFB1, PLAU, TP53, ERBB2
35vitamin d32 6.4MMP3, JUN, BMP6, SERPINE1, FN1, ERBB2
36vegf32 6.4CP, SOD2, CX3CR1, TGFB1, PLAU, BCL2
37indomethacin32 9 9 8.4CP, SOD2, SOD1, TFRC, TGFB1, PLAU
38butyrate32 6.3IL8, FN1, MMP3, JUN, BCL2, BMP6
39paraffin32 6.2MBL2, FAS, FASLG, IL4, FN1, MMP3
40herbimycin a32 42 7.1CCL2, BMP6, FAS, IL8, IL6, IL4
41pdtc32 5.7CP, SOD2, SOD1, IL1A, JUN, BCL2
42pd 98,05932 5.5TNF, CASP8, HSPA4, HSPA1A, CCL2, FAS
43lactate32 5.4BMP6, FAS, FASLG, IL8, IL6, IL2RB
44curcumin32 5.2CASP8, BCL2, JUN, CAT, HSPA4, CCL2
45genistein32 9 18 9 8.1FAS, FASLG, IL8, IL6, IL2RB, IL1B
46retinoic acid32 42 18 6.6PLAT, TNFRSF1B, TNF, TP53, CASP8, HSPA4
47serine32 4.4ERBB2, CASP8, HSPA4, CCR5, CCL2, MBL2
48actinomycin d32 4.1SOD2, TFRC, TGFB1, PLAU, FASLG, IL8
49dexamethasone32 42 34 9 9 7.5SOD2, TFRC, TGFB1, TNFRSF1B, TNF, ERBB2
50cycloheximide32 3.0SOD2, TFRC, TGFB1, PLAU, PLAT, TNFRSF1B

GO Terms for genes affiliated with Pneumoconiosis

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12Gene Ontology
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Cellular components related to pneumoconiosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular ferritin complexGO:00804310.3FTH1, FTL
2external side of plasma membraneGO:0098978.6TNF, HLA-DRB1, CCR5, FAS, FASLG, IL4
3cytosolGO:0058296.4CCR2, HSPA1B, HSPA4, CAT, CASP8, TP53
4extracellular regionGO:0055766.2MBL2, CCL2, TNFRSF1B, PLAT, PLAU, TGFB1
5extracellular spaceGO:0056156.1SFTPA1, MBL2, CCL2, TNF, PLAT, PLAU

Biological processes related to pneumoconiosis according to GeneDecks:

(show top 50)    (show all 55)
idNameGO IDScoreTop Affiliating Genes
1cellular iron ion homeostasisGO:00687910.4CP, SOD1, TFRC, FTL, FTH1
2chronic inflammatory response to antigenic stimulusGO:00243910.4IL1RN, IL1B
3chemokine-mediated signaling pathwayGO:07009810.4CCR2, CCL2, CCR5, CX3CR1
4negative regulation of angiogenesisGO:01652510.2CX3CR1, CCL2, CCR2, FASLG
5inflammatory cell apoptotic processGO:00692510.0FASLG, FAS
6positive regulation of membrane protein ectodomain proteolysisGO:05104410.0IL1B, TNF, TNFRSF1B
7response to woundingGO:0096119.9CX3CR1, TGFB1, CCR2, FN1
8response to L-ascorbic acidGO:0335919.9BCL2, IL1A, IL1B
9protein kinase B signaling cascadeGO:0434919.9TGFB1, TNF, CCL2, IL1B
10lipopolysaccharide-mediated signaling pathwayGO:0316639.9TGFB1, TNF, CCL2, IL1B
11cellular response to organic cyclic compoundGO:0714079.9TGFB1, TNF, CCL2, IL1B
12regulation of vascular endothelial growth factor productionGO:0105749.9CCL2, CCR2, IL6
13positive regulation of chemokine biosynthetic processGO:0450809.9TNF, IL4, IL1B
14chemotaxisGO:0069359.9CX3CR1, PLAU, CCR5, CCL2, CCR2, IL4
15induction of apoptosis via death domain receptorsGO:0086259.9FASLG, FAS, TNF
16positive regulation of cell divisionGO:0517819.8TGFB1, CAT, IL1B, IL1A
17fibrinolysisGO:0427309.8PLAU, PLAT, SERPINE1
18response to copper ionGO:0466889.8BCL2, IL1A, SOD1
19response to radiationGO:0093149.8OGG1, TGFB1, JUN, BCL2
20activation of pro-apoptotic gene productsGO:0086339.7CASP8, FAS, FASLG, BCL2
21response to ethanolGO:0454719.7SOD1, CASP8, CCL2, IL4, BCL2
22MAPK cascadeGO:0001659.7TGFB1, TNF, CCR5, CCL2, IL1B
23cellular response to lipopolysaccharideGO:0712229.6CX3CR1, TNFRSF1B, CCR5, CCL2, IL8, SERPINE1
24female pregnancyGO:0075659.6TGFB1, IL4, IL1RN, SCGB1A1, BCL2
25release of cytochrome c from mitochondriaGO:0018369.5SOD2, TP53, JUN, BCL2
26acute-phase responseGO:0069539.5FN1, IL1RN, IL6, MBL2
27agingGO:0075689.5JUN, IL1B, FAS, CCL2, TGFB1
28response to lipopolysaccharideGO:0324969.5JUN, IL1A, FASLG, FAS, CASP8
29response to heatGO:0094089.5SOD1, HSPA4, CCL2, IL1B, BCL2
30response to cytokine stimulusGO:0340979.4IL4, JUN, BCL2, SERPINE1
31response to gamma radiationGO:0103329.4TP53, CCL2, IL1B, IL1A, BCL2
32cellular defense responseGO:0069689.4IL4, CCR2, CCR5, CX3CR1
33transforming growth factor beta receptor signaling pathwayGO:0071799.3SERPINE1, JUN, CCL2, TP53, TGFB1
34angiogenesisGO:0015259.2CASP8, CCL2, IL8, FN1, JUN, SERPINE1
35humoral immune responseGO:0069599.2TNF, CCL2, IL6, BCL2
36positive regulation of interleukin-6 productionGO:0327559.2TNF, IL6, IL1B, IL1A
37positive regulation of apoptotic processGO:0430659.2SOD1, TNF, TP53, FAS, FASLG, IL1B
38virus-host interactionGO:0190489.2CX3CR1, TFRC, TGFB1, TP53, CASP8, CCR5
39anti-apoptosisGO:0069169.2SOD1, TNF, HSPA1B, CCL2, FAS, IL1B
40positive regulation of peptidyl-serine phosphorylationGO:0331389.0BCL2, IL6, TNF, TGFB1
41positive regulation of NF-kappaB transcription factor activityGO:0510929.0TGFB1, TNF, CAT, IL6, IL1B
42response to hypoxiaGO:0016668.8TGFB1, PLAT, TNF, CAT, CCL2, FAS
43response to drugGO:0424938.7SOD1, TGFB1, TNF, CCL2, FAS, IL4
44cytokine-mediated signaling pathwayGO:0192218.7HLA-DRB1, HLA-DQB1, CCL2, CCR2, IL6, IL2RB
45response to glucocorticoid stimulusGO:0513848.6SERPINE1, PLAT, TNF, CCL2, FAS, IL6
46immune responseGO:0069558.5CCR2, CCR5, HLA-DQB1, HLA-DRB1, FASLG, IL8
47inflammatory responseGO:0069547.9TGFB1, TNFRSF1B, TNF, CCR5, CCL2, CCR2
48negative regulation of apoptotic processGO:0430667.9TP53, TNF, CX3CR1, SOD2, CAT, IL6
49positive regulation of transcription from RNA polymerase II promoterGO:0459447.6TGFB1, TNF, TP53, IL6, IL4, IL1B
50negative regulation of cell proliferationGO:0082857.4SOD2, TGFB1, TNF, TP53, HSPA1B, IL8

Molecular functions related to pneumoconiosis according to GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1superoxide dismutase activityGO:00478410.2SOD1, SOD2
2interleukin-1 receptor bindingGO:0051499.9IL1RN, IL1B, IL1A
3chemokine receptor activityGO:0049509.7CCR2, CCR5, CX3CR1
4copper ion bindingGO:0055079.6CP, SOD1, TP53, IL1A
5protease bindingGO:0020209.2SERPINE1, BCL2, HSPA1B, TP53, TNF
6cytokine activityGO:0051258.5BMP6, TNF, FASLG, IL6, IL4, IL1B
7identical protein bindingGO:0428028.1TNF, TP53, ERBB2, CASP8, FAS, FTL
8protein bindingGO:0055154.7CASP8, ERBB2, TP53, TNF, TNFRSF1B, PLAT

Sources for Pneumoconiosis

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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