MCID: PNM006
MIFTS: 55

Pneumoconiosis

Categories: Respiratory diseases

Aliases & Classifications for Pneumoconiosis

MalaCards integrated aliases for Pneumoconiosis:

Name: Pneumoconiosis 12 72 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10316
ICD10 32 J64
ICD9CM 34 505
MeSH 41 D011009
NCIt 46 C26861
UMLS 69 C0032273

Summaries for Pneumoconiosis

Disease Ontology : 12 An interstitial lung disease that is caused by the inhalation of dust.

MalaCards based summary : Pneumoconiosis is related to silicosis and pulmonary disease, chronic obstructive. An important gene associated with Pneumoconiosis is CAT (Catalase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Iron and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 72 Pneumoconiosis is an occupational lung disease and a restrictive lung disease caused by the inhalation... more...

Related Diseases for Pneumoconiosis

Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
# Related Disease Score Top Affiliating Genes
1 silicosis 30.7 CCL2 CXCL8 FAS FASLG IL1A IL1B
2 pulmonary disease, chronic obstructive 30.4 CXCL8 IL6 TNF
3 arteries, anomalies of 29.9 CCL2 IL1B IL6 TNF
4 pulmonary fibrosis 29.9 CCL2 IL1B MUC5B TGFB1
5 esophagitis 29.9 CXCL8 IL1B IL6 TGFB1
6 arthritis 29.6 CCL2 CXCL8 IL1A IL1B IL6 TNF
7 lung disease 29.4 CCL2 CXCL8 IL1B MUC5B TGFB1 TNF
8 rheumatoid arthritis 29.0 CAT CCL2 CXCL8 IL1A IL1B IL6
9 pneumonia 28.9 CCL2 CXCL8 IL1B IL6 MUC5B SCGB1A1
10 respiratory failure 28.9 CXCL8 SCGB1A1 TNF
11 pulmonary fibrosis, idiopathic 27.9 CCL2 CXCL8 FASLG IL1A IL1B MUC5B
12 kaolin pneumoconiosis 12.3
13 pneumoconiosis due to talc 12.2
14 anthracosis 12.1
15 graphite pneumoconiosis 12.1
16 mixed mineral dust pneumoconiosis 11.9
17 slate pneumoconiosis 11.9
18 caplan's syndrome 11.8
19 asbestosis 11.5
20 baritosis 11.4
21 berylliosis 11.4
22 labrador lung 11.4
23 nontuberculous mycobacterial lung disease 10.9
24 silicosiderosis 10.9
25 asbestos intoxication 10.7
26 polyposis, gastric 10.6 IL1B TNF
27 scorpion envenomation 10.6 IL6 TNF
28 systemic onset juvenile idiopathic arthritis 10.6 IL1B TNF
29 staphylococcal toxic shock syndrome 10.5 IL1B TNF
30 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
31 posterior urethral valves 10.5 IL6 TGFB1 TNF
32 critical limb ischemia 10.5 IL6 TNF
33 poems syndrome 10.5 IL1B IL6 TNF
34 burning mouth syndrome 10.5 IL1B IL6 TNF
35 central nervous system vasculitis 10.5 IL1B IL6 TNF
36 osteosclerotic myeloma 10.5 IL1B IL6 TNF
37 beryllium disease 10.5 TGFB1 TNF
38 kashin-beck disease 10.5 FAS IL1B TNF
39 localized scleroderma 10.5 IL6 TGFB1 TNF
40 endometritis 10.5 IL1B IL6 TNF
41 joint disorders 10.5 IL1B IL6 TNF
42 burn scar 10.5 FAS TGFB1
43 lacrimal apparatus disease 10.5 IL1B IL6 TNF
44 adult-onset still's disease 10.5 IL1B IL6 TNF
45 gingival disease 10.5 IL1B IL6 TGFB1
46 commensal bacterial infectious disease 10.5 IL1B IL6 TNF
47 rheumatic heart disease 10.5 IL6 TGFB1 TNF
48 chikungunya 10.5 IL1B IL6 TNF
49 pericarditis 10.5 IL1B IL6 TNF
50 typhoid fever 10.5 IL1B IL6 TNF

Comorbidity relations with Pneumoconiosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Chronic Myocardial Ischemia Familial Atrial Fibrillation
Heart Disease Ischemic Heart Disease
Postinflammatory Pulmonary Fibrosis Prostatic Hypertrophy
Respiratory Failure

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to Pneumoconiosis

Symptoms & Phenotypes for Pneumoconiosis

GenomeRNAi Phenotypes related to Pneumoconiosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.89 IL1B NLRP3 SOD1 CASP8 TGFB1 CXCL8
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.89 IL1A IL1B NLRP3 SOD1 CASP8 TGFB1

MGI Mouse Phenotypes related to Pneumoconiosis:

43 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 FAS CASP8 FASLG CAT IL1A CP
2 immune system MP:0005387 10.25 CASP8 FASLG CCL2 CP IL1A IL1B
3 hematopoietic system MP:0005397 10.23 TNF IL1B FAS CASP8 FASLG CP
4 cellular MP:0005384 10.22 TNF FAS CASP8 FASLG CAT CP
5 cardiovascular system MP:0005385 10.19 TNF IL1B FAS CASP8 FASLG CP
6 integument MP:0010771 10.07 TNF IL1B FAS CASP8 FASLG IL1A
7 mortality/aging MP:0010768 10.03 TNF FAS CASP8 CAT FASLG NLRP3
8 liver/biliary system MP:0005370 9.97 CASP8 FASLG CP FAS TNF IL6
9 neoplasm MP:0002006 9.9 CASP8 FASLG CAT IL1A IL1B FAS
10 renal/urinary system MP:0005367 9.5 FAS CASP8 FASLG SCGB1A1 IL6 TGFB1
11 respiratory system MP:0005388 9.23 TNF FAS CASP8 FASLG SCGB1A1 IL6

Drugs & Therapeutics for Pneumoconiosis

Drugs for Pneumoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2 Liver Extracts Phase 4
3 Micronutrients Phase 4
4 Trace Elements Phase 4
5
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
6
Metoprolol Approved, Investigational Phase 2, Phase 3 51384-51-1, 37350-58-6 4171
7
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
8
Rifampin Approved Phase 3 13292-46-1 5381226 5458213
9
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
10 Adrenergic Agents Phase 2, Phase 3
11 Adrenergic Antagonists Phase 2, Phase 3
12 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
13 Adrenergic beta-Antagonists Phase 2, Phase 3
14 Anti-Arrhythmia Agents Phase 2, Phase 3
15 Antihypertensive Agents Phase 2, Phase 3
16 Autonomic Agents Phase 2, Phase 3
17 calcium channel blockers Phase 2, Phase 3
18 Calcium, Dietary Phase 2, Phase 3
19 Neurotransmitter Agents Phase 2, Phase 3
20 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
21 Sympatholytics Phase 2, Phase 3
22 Vasodilator Agents Phase 2, Phase 3
23 Anti-Bacterial Agents Phase 3
24 Antibiotics, Antitubercular Phase 3
25 Anti-Infective Agents Phase 3
26 Antimetabolites Phase 3
27 Antitubercular Agents Phase 3
28 Cytochrome P-450 CYP3A Inducers Phase 3
29 Hypolipidemic Agents Phase 3
30 Lipid Regulating Agents Phase 3
31 Nucleic Acid Synthesis Inhibitors Phase 3
32
Infliximab Approved Phase 1, Phase 2 170277-31-3
33 Mitogens Phase 1, Phase 2
34 Analgesics Phase 1, Phase 2
35 Analgesics, Non-Narcotic Phase 1, Phase 2
36 Anti-Inflammatory Agents Phase 1, Phase 2
37 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
38 Antirheumatic Agents Phase 1, Phase 2
39 Mesalamine Phase 1, Phase 2 89-57-6
40 Dermatologic Agents Phase 1, Phase 2
41 Gastrointestinal Agents Phase 1, Phase 2
42
Deferiprone Approved 30652-11-0 2972
43
Heparin Approved, Investigational 9005-49-6 46507594 772
44 Respiratory System Agents
45 Chelating Agents
46 Iron Chelating Agents
47 calcium heparin
48 Pharmaceutical Solutions
49 Xenon Early Phase 1

Interventional clinical trials:

(show all 25)

# Name Status NCT ID Phase Drugs
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome Unknown status NCT02408172 Phase 2, Phase 3 Amlodipine;metoprolol
3 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Recruiting NCT02430259 Phase 3 Weekly INH / RRT given by DOT
4 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
5 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
6 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
7 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
8 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Recruiting NCT02668068 Phase 1
9 Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Not yet recruiting NCT02790762 Phase 1
10 Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis Unknown status NCT02280343
11 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
12 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
13 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
14 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
15 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
16 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Completed NCT01284127
17 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
18 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
19 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
20 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
21 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Recruiting NCT02794701
22 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693
23 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Recruiting NCT02596347
24 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
25 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1 HP 3He;HP 129Xe;PFP;SF6

Search NIH Clinical Center for Pneumoconiosis

Cochrane evidence based reviews: pneumoconiosis

Genetic Tests for Pneumoconiosis

Anatomical Context for Pneumoconiosis

MalaCards organs/tissues related to Pneumoconiosis:

38
Lung, Liver, Heart, Testes, Bone Marrow, Bone, Monocytes

Publications for Pneumoconiosis

Articles related to Pneumoconiosis:

(show top 50) (show all 641)
# Title Authors Year
1
Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269. ( 29415464 )
2018
2
A response to the Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269 by the Author Mei Yong. ( 29438277 )
2018
3
Association analysis identifies new risk loci for coal workers' pneumoconiosis in Han Chinese men. ( 29394417 )
2018
4
Prevalence and characteristics of COPD among pneumoconiosis patients at an occupational disease prevention institute: a cross-sectional study. ( 29378587 )
2018
5
Estimated economic costs of coal workers' pneumoconiosis among coal workers redeployed from the Fuxin mining group in China. ( 29116190 )
2018
6
TNFR/TNF-I+ signaling pathway regulates apoptosis of alveolar macrophages in coal workers' pneumoconiosis. ( 29416696 )
2018
7
Increasing Severity of Pneumoconiosis Among Younger Former US Coal Miners Working Exclusively Under Modern Dust-Control Regulations. ( 28598937 )
2017
8
Coal miner participation in a job transfer program designed to prevent progression of pneumoconiosis, United States, 1986-2016. ( 29116886 )
2017
9
Progressive massive fibrosis in patients with pneumoconiosis: utility of MRI in differentiating from lung cancer. ( 28361545 )
2017
10
Evaluation of dental technician's pneumoconiosis using chest X-rayand HRCT: correlation between radiological and functional findings. ( 28263498 )
2017
11
TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis. ( 28698801 )
2017
12
The association of LAMB1 polymorphism and expression changes with the risk of coal workers' pneumoconiosis. ( 28444932 )
2017
13
Diagnostic and clinical application value of magnetic resonance imaging (MRI) for progressive massive fibrosis of coal worker pneumoconiosis: Case reports. ( 28514304 )
2017
14
Element-based prognostics of occupational pneumoconiosis using micro-proton-induced X-ray emission analysis. ( 28912379 )
2017
15
Development of breath test for pneumoconiosis: a case-control study. ( 29041938 )
2017
16
Cross-section analysis of coal workers' pneumoconiosis and higher brachial-ankle pulse wave velocity within Kailuan study. ( 28148238 )
2017
17
Dental Technicians' Pneumoconiosis. ( 29021460 )
2017
18
LRBA Gene Polymorphisms and Risk of Coal Workers' Pneumoconiosis: A Case-Control Study from China. ( 28953250 )
2017
19
A case of mixed dust pneumoconiosis with desquamative interstitial pneumonia-like reaction in an aluminum welder. ( 28239542 )
2017
20
Polymorphisms in autophagy related genes and the coal workers' pneumoconiosis in a Chinese population. ( 28844669 )
2017
21
Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. ( 28272360 )
2017
22
Daytime blood pressure surges following hypoxic episodes in a case of pneumoconiosis with lacunar stroke recurrences. ( 28263202 )
2017
23
Wood charcoal dust pneumoconiosis. ( 28365221 )
2017
24
Loss of regulatory characteristics in CD4(+) CD25(+/hi) T cells induced by impaired transforming growth factor beta secretion in pneumoconiosis. ( 28913840 )
2017
25
Survival Analysis of Coal Workers' Pneumoconiosis (CWP) Patients in a State-Owned Mine in the East of China from 1963 to 2014. ( 28481235 )
2017
26
Squamous cell carcinoma of the lung showing a ground glass nodule on high-resolution computed tomography associated with pneumoconiosis: a case report. ( 28963659 )
2017
27
Association between Genetic Variants of Transforming Growth Factor-I^1 and Susceptibility of Pneumoconiosis: A Meta-analysis. ( 28139521 )
2017
28
Diagnostic accuracy of breath tests for pneumoconiosis using an electronic nose. ( 28795953 )
2017
29
Differential gene expression associated with inflammation in peripheral blood cells of patients with pneumoconiosis. ( 27265534 )
2016
30
Platelet Indices in Patients with Coal Workers' Pneumoconiosis. ( 27107875 )
2016
31
Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population. ( 27621877 )
2016
32
Lung transplantation is increasingly common among patients with coal workers' pneumoconiosis. ( 26725917 )
2016
33
Plasma LncRNA-ATB, a Potential Biomarker for Diagnosis of Patients with Coal Workers' Pneumoconiosis: A Case-Control Study. ( 27556453 )
2016
34
Risk of Cerebrovascular Events in Pneumoconiosis Patients: A Population-based Study, 1996-2011. ( 26945404 )
2016
35
Pneumoconiosis Redux. Coal Workers' Pneumoconiosis and Silicosis Are Still a Problem. ( 26977968 )
2016
36
Dental technician pneumoconiosis mimicking pulmonary tuberculosis: a case report. ( 27604085 )
2016
37
Endogenous pneumoconiosis: Analytical scanning electron microscopic analysis of a case. ( 27281119 )
2016
38
Aluminum-induced pneumoconiosis confirmed by analytical scanning electron microscopy: A case report and review of the literature. ( 26895029 )
2016
39
Screening and Preliminary Verification of a Phage Display Single-Chain Antibody Library Against Coal Workers' Pneumoconiosis. ( 27930489 )
2016
40
Ocular findings in coal miners diagnosed with pneumoconiosis. ( 27292375 )
2016
41
Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers' Pneumoconiosis in a Chinese Population. ( 27626436 )
2016
42
Pneumoconiosis in different sectors and their differences in Turkey. ( 28393716 )
2016
43
Risk factors associated with mortality from pneumonia among patients with pneumoconiosis. ( 27057317 )
2016
44
Pneumoconiosis increases the risk of congestive heart failure: A nationwide population-based cohort study. ( 27336897 )
2016
45
Estimates and Predictions of Coal Workers' Pneumoconiosis Cases among Redeployed Coal Workers of the Fuxin Mining Industry Group in China: A Historical Cohort Study. ( 26845337 )
2016
46
Positive FDG PET/CT findings in a patient with pneumoconiosis. ( 28393722 )
2016
47
Ocular findings in coal miners diagnosed with pneumoconiosis. ( 27406957 )
2016
48
The relation between the extent of radiological findings and respiratory functions in pneumoconiosis cases of dental technicians who are working in Ankara. ( 27481079 )
2016
49
Endobronchial fibroma in a pneumoconiosis patient with a history of tuberculosis: A case report and literature review. ( 27446391 )
2016
50
Coal workers' pneumoconiosis: an Australian perspective. ( 27318401 )
2016

Variations for Pneumoconiosis

Expression for Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for Pneumoconiosis

Pathways related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 CASP8 CAT CCL2 CXCL8 FASLG IL1A
2
Show member pathways
13.9 CASP8 CCL2 CXCL8 FAS FASLG IL1A
3
Show member pathways
13.74 CASP8 CCL2 CXCL8 FAS FASLG IL1A
4
Show member pathways
13.57 CASP8 CXCL8 FAS FASLG IL1A IL1B
5
Show member pathways
13.5 CCL2 CXCL8 FAS FASLG IL1A IL1B
6
Show member pathways
13.44 CCL2 CXCL8 FASLG IL1A IL1B IL6
7
Show member pathways
13.38 CASP8 CCL2 CXCL8 FAS FASLG IL1A
8
Show member pathways
13.19 CAT CXCL8 HSPA1L IL1A IL6 SOD1
9
Show member pathways
13.03 CASP8 CCL2 CP CXCL8 IL1A IL1B
10
Show member pathways
12.98 CASP8 CCL2 FAS FASLG IL6 TNF
11 12.95 CASP8 CXCL8 FAS FASLG GSTM1 IL6
12 12.86 CASP8 FAS FASLG HSPA1L IL1A IL1B
13
Show member pathways
12.84 CASP8 CXCL8 FAS FASLG HSPA1L IL1A
14
Show member pathways
12.79 CASP8 CXCL8 IL1B IL6 TNF
15
Show member pathways
12.77 IL1A IL1B IL6 TGFB1 TNF
16
Show member pathways
12.74 FAS FASLG IL1A IL1B TNF
17
Show member pathways
12.72 CASP8 FAS FASLG IL1A IL1B TNF
18
Show member pathways
12.69 CASP8 CXCL8 FAS FASLG IL6 TGFB1
19
Show member pathways
12.68 IL1A IL1B IL6 TGFB1 TNF
20 12.65 CCL2 FAS FASLG IL1B TNF
21
Show member pathways
12.55 FAS IL1A IL1B IL6 TGFB1 TNF
22
Show member pathways
12.46 CAT CCL2 IL1B IL6 SOD1 TNF
23
Show member pathways
12.46 CASP8 CCL2 CXCL8 FAS FASLG IL1B
24
Show member pathways
12.45 CASP8 CCL2 CXCL8 IL1B IL6 MUC5B
25
Show member pathways
12.39 CASP8 FAS FASLG TNF
26
Show member pathways
12.39 CXCL8 IL1A IL1B IL6 TNF
27
Show member pathways
12.39 CASP8 HSPA1L IL1A IL1B TGFB1 TNF
28 12.37 FAS FASLG TGFB1 TNF
29
Show member pathways
12.37 CASP8 FAS FASLG IL1A TNF
30 12.36 CASP8 IL1A IL1B IL6 TGFB1 TNF
31
Show member pathways
12.33 CXCL8 IL1A IL6 TNF
32
Show member pathways
12.33 CASP8 FAS FASLG IL1A IL1B NLRP3
33 12.32 CASP8 FAS FASLG TNF
34
Show member pathways
12.31 CXCL8 FAS FASLG IL1B IL6 TNF
35 12.3 CXCL8 IL1A IL1B IL6 TNF
36
Show member pathways
12.28 CXCL8 IL1A IL1B IL6 TNF
37 12.25 CXCL8 IL1A IL6 TGFB1
38 12.22 CCL2 GSTM1 IL1A IL1B TNF
39
Show member pathways
12.18 CAT FASLG IL6 TGFB1
40 12.16 FAS IL6 TGFB1 TNF
41 12.14 IL1A IL1B TGFB1 TNF
42 12.1 CCL2 CXCL8 IL1A IL1B IL6 TGFB1
43 12.09 CASP8 CCL2 FAS IL1B IL6 TNF
44 12.08 CXCL8 IL1A IL1B IL6 TGFB1
45
Show member pathways
12.06 CASP8 CCL2 CXCL8 FAS FASLG HSPA1L
46
Show member pathways
12.04 IL1B IL6 TGFB1 TNF
47 12.02 CXCL8 IL1B IL6 TGFB1 TNF
48 12 IL1A IL1B IL6 TNF
49 11.95 CXCL8 IL1A IL1B IL6
50 11.92 CXCL8 IL1B TNF

GO Terms for Pneumoconiosis

Cellular components related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 CAT CCL2 CP CXCL8 FASLG IL1A
2 membrane raft GO:0045121 9.67 CASP8 FAS FASLG TNF
3 extracellular region GO:0005576 9.5 CAT CCL2 CP CXCL8 FAS FASLG
4 secretory granule GO:0030141 9.46 IL1B SCGB1A1 SOD1 TGFB1
5 death-inducing signaling complex GO:0031264 9.32 CASP8 FAS
6 CD95 death-inducing signaling complex GO:0031265 9.26 CASP8 FAS

Biological processes related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 CASP8 FASLG IL1B TNF
2 response to lipopolysaccharide GO:0032496 9.97 CASP8 FAS FASLG IL1B SCGB1A1
3 positive regulation of protein phosphorylation GO:0001934 9.95 FAS IL1B TGFB1 TNF
4 cytokine-mediated signaling pathway GO:0019221 9.94 CCL2 IL1A IL1B IL6
5 immune response GO:0006955 9.92 CCL2 CXCL8 FAS FASLG IL1A IL1B
6 defense response to Gram-positive bacterium GO:0050830 9.9 IL6 NLRP3 TNF
7 response to organic substance GO:0010033 9.89 SCGB1A1 SOD1 TGFB1 TNF
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.88 IL6 TGFB1 TNF
9 regulation of inflammatory response GO:0050727 9.88 NLRP3 SCGB1A1 TNF
10 cellular response to mechanical stimulus GO:0071260 9.88 CASP8 FAS IL1B TGFB1
11 cellular response to lipopolysaccharide GO:0071222 9.88 CCL2 CXCL8 IL6 NLRP3 TNF
12 neutrophil chemotaxis GO:0030593 9.87 CCL2 CXCL8 IL1B
13 response to glucocorticoid GO:0051384 9.87 IL6 SCGB1A1 TNF
14 humoral immune response GO:0006959 9.86 CCL2 IL6 TNF
15 apoptotic signaling pathway GO:0097190 9.86 CASP8 FAS FASLG TNF
16 negative regulation of fat cell differentiation GO:0045599 9.83 IL6 TGFB1 TNF
17 positive regulation of interleukin-6 production GO:0032755 9.83 IL1A IL1B IL6 TNF
18 positive regulation of cell division GO:0051781 9.81 CAT IL1A IL1B TGFB1
19 embryo implantation GO:0007566 9.8 IL1B SCGB1A1 SOD1
20 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.8 IL1A IL1B TNF
21 protein kinase B signaling GO:0043491 9.8 CCL2 IL1B TGFB1 TNF
22 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.8 CASP8 FAS FASLG NLRP3 TNF
23 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.79 CASP8 FAS FASLG
24 positive regulation of vascular endothelial growth factor production GO:0010575 9.77 IL1A IL1B TGFB1
25 cellular response to organic cyclic compound GO:0071407 9.77 CASP8 CCL2 IL1B TGFB1 TNF
26 regulation of receptor activity GO:0010469 9.76 CCL2 CXCL8 FASLG IL1A IL1B IL6
27 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.75 CASP8 FAS FASLG
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 CCL2 IL1B TGFB1 TNF
29 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 CAT IL1B IL6 NLRP3 TGFB1 TNF
30 positive regulation of superoxide anion generation GO:0032930 9.72 SOD1 TGFB1
31 response to reactive oxygen species GO:0000302 9.72 CAT SOD1
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL1B TNF
33 PERK-mediated unfolded protein response GO:0036499 9.71 CCL2 CXCL8
34 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.71 IL1A IL1B
35 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.71 IL1A IL1B
36 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.71 CASP8 FAS FASLG
37 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
38 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
39 death-inducing signaling complex assembly GO:0071550 9.7 CASP8 TNF
40 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
41 ectopic germ cell programmed cell death GO:0035234 9.68 IL1A IL1B
42 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.68 IL6 NLRP3
43 response to ozone GO:0010193 9.67 CAT SCGB1A1
44 interleukin-1 beta production GO:0032611 9.66 IL1B NLRP3
45 fever generation GO:0001660 9.66 IL1A IL1B
46 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
47 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.64 IL1A TGFB1
48 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
49 necroptotic signaling pathway GO:0097527 9.63 FAS FASLG TNF
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF

Molecular functions related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 9.33 CP IL1A SOD1
2 cytokine activity GO:0005125 9.23 CCL2 CXCL8 FASLG IL1A IL1B IL6
3 tumor necrosis factor receptor binding GO:0005164 9.13 CASP8 FASLG TNF

Sources for Pneumoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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