MCID: PNM006
MIFTS: 50

Pneumoconiosis

Categories: Respiratory diseases

Aliases & Classifications for Pneumoconiosis

MalaCards integrated aliases for Pneumoconiosis:

Name: Pneumoconiosis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10316
ICD10 33 J64
ICD9CM 35 505
MeSH 42 D011009
NCIt 47 C26861
UMLS 69 C0032273

Summaries for Pneumoconiosis

Disease Ontology : 12 An interstitial lung disease that is caused by the inhalation of dust.

MalaCards based summary : Pneumoconiosis is related to mixed mineral dust pneumoconiosis and berylliosis. An important gene associated with Pneumoconiosis is CAT (Catalase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Iron and Micronutrients have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Wikipedia : 72 Pneumoconiosis is an occupational lung disease and a restrictive lung disease caused by the inhalation... more...

Related Diseases for Pneumoconiosis

Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 266)
id Related Disease Score Top Affiliating Genes
1 mixed mineral dust pneumoconiosis 33.4 CXCL8 IL6 TNF
2 berylliosis 32.0 CAT GSTM1 IL6 OGG1
3 pulmonary hypertension 30.5 FAS IL1B TNF
4 pulmonary tuberculosis 30.3 CCL2 CXCL8 TNF
5 rheumatoid arthritis 29.1 CCL2 CXCL8 IL1A IL1B IL6 TGFB1
6 asbestosis 24.2 CASP8 CAT CCL2 CXCL8 FAS FASLG
7 pneumoconiosis due to talc 12.0
8 kaolin pneumoconiosis 12.0
9 graphite pneumoconiosis 11.9
10 silicosis 11.9
11 anthracosis 11.7
12 slate pneumoconiosis 11.7
13 caplan's syndrome 11.6
14 silicosiderosis 11.3
15 labrador lung 11.3
16 baritosis 11.3
17 smarca4-deficient sarcoma of thorax 10.9 IL6 TNF
18 tabatznik syndrome 10.8 IL1B TNF
19 myoclonic encephalopathy of infants 10.8 CAT SOD1
20 sternal cleft 10.8 IL1B TNF
21 bipolar i disorder 10.8 IL1B IL6 TNF
22 tinea favosa 10.8 IL1B IL6 TNF
23 central nervous system leiomyosarcoma 10.8 IL1B IL6 TNF
24 aortic arch interruption 10.8 IL6 TNF
25 indolent myeloma 10.8 IL1B IL6 TNF
26 potato nose 10.8 IL6 TGFB1 TNF
27 ampulla of vater neoplasm 10.7 IL1B IL6 TNF
28 benign neonatal seizures 10.7 IL1B IL6 TNF
29 nontuberculous mycobacterial lung disease 10.7
30 aluminium lung 10.7
31 keloids 10.7 IL1B IL6 TNF
32 brucella canis brucellosis 10.7 IL1B IL6 TNF
33 foodborne botulism 10.7 IL1B IL6 TNF
34 human monocytic ehrlichiosis 10.7 IL1B IL6 TNF
35 rheumatic myocarditis 10.7 IL6 TGFB1 TNF
36 cholera 10.7 IL1B IL6 TGFB1
37 pancreas lymphoma 10.7 IL1B IL6 TNF
38 rift valley fever 10.7 IL1B IL6 TNF
39 cutaneous leishmaniasis 10.7 IL6 TNF
40 uterine adnexa cancer 10.7 IL1B IL6 TNF
41 biemond syndrome 10.7 TGFB1 TNF
42 cartilage disease 10.7 FAS TGFB1
43 opportunistic bacterial infectious disease 10.7 IL1B IL6 TNF
44 antigen-peptide-transporter 2 deficiency 10.7 CCL2 IL6 TNF
45 hypervitaminosis d 10.7 IL1B IL6 TNF
46 amyotrophic lateral sclerosis type 10 10.6 CXCL8 IL1B TNF
47 epulis 10.6 CXCL8 IL1B TNF
48 oculomotor nerve paralysis 10.6 CXCL8 IL1B IL6
49 common peroneal nerve lesion 10.6 CXCL8 IL1B IL6
50 spirillary rat-bite fever 10.6 CXCL8 IL6 TNF

Comorbidity relations with Pneumoconiosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Chronic Myocardial Ischemia Familial Atrial Fibrillation
Heart Disease Ischemic Heart Disease
Postinflammatory Pulmonary Fibrosis Prostatic Hypertrophy
Respiratory Failure

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to Pneumoconiosis

Symptoms & Phenotypes for Pneumoconiosis

GenomeRNAi Phenotypes related to Pneumoconiosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.89 TNF IL1A IL1B NLRP3 SOD1 TGFB1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.89 FASLG TNF IL1A IL1B NLRP3 SOD1

MGI Mouse Phenotypes related to Pneumoconiosis:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 SOD1 TGFB1 TNF CASP8 CAT FAS
2 immune system MP:0005387 10.25 IL1B IL6 MUC5B NLRP3 OGG1 SCGB1A1
3 hematopoietic system MP:0005397 10.23 CASP8 FAS FASLG IL1A IL1B IL6
4 cellular MP:0005384 10.22 TGFB1 TNF CASP8 CAT FAS FASLG
5 cardiovascular system MP:0005385 10.15 FASLG IL1A IL1B IL6 SOD1 TGFB1
6 integument MP:0010771 10.07 CASP8 FAS FASLG IL1A IL1B IL6
7 mortality/aging MP:0010768 10.07 CASP8 CAT FAS FASLG IL1B IL6
8 liver/biliary system MP:0005370 9.97 CASP8 FAS FASLG IL6 NLRP3 OGG1
9 neoplasm MP:0002006 9.93 CASP8 CAT FAS FASLG IL1A IL1B
10 renal/urinary system MP:0005367 9.5 CASP8 FAS FASLG IL6 NLRP3 SCGB1A1
11 respiratory system MP:0005388 9.23 FASLG IL6 MUC5B SCGB1A1 TGFB1 TNF

Drugs & Therapeutics for Pneumoconiosis

Drugs for Pneumoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2 Micronutrients Phase 4
3 Trace Elements Phase 4
4 Liver Extracts Phase 4
5
Rifampin Approved Phase 3 13292-46-1 5458213 5381226
6
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
7
Metoprolol Approved, Investigational Phase 2, Phase 3 37350-58-6, 51384-51-1 4171
8
Isoniazid Approved Phase 3 54-85-3 3767
9
Rifapentine Approved Phase 3 61379-65-5 6323497
10 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
11 calcium channel blockers Phase 2, Phase 3
12 Adrenergic Agents Phase 2, Phase 3
13 Adrenergic Antagonists Phase 2, Phase 3
14 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
15 Adrenergic beta-Antagonists Phase 2, Phase 3
16 Sympatholytics Phase 2, Phase 3
17 Neurotransmitter Agents Phase 2, Phase 3
18 Cytochrome P-450 CYP3A Inducers Phase 3
19 Nucleic Acid Synthesis Inhibitors Phase 3
20 Vasodilator Agents Phase 2, Phase 3
21 Anti-Arrhythmia Agents Phase 2, Phase 3
22 Anti-Bacterial Agents Phase 3
23 Hypolipidemic Agents Phase 3
24 Anti-Infective Agents Phase 3
25 Antihypertensive Agents Phase 2, Phase 3
26 Lipid Regulating Agents Phase 3
27 Antibiotics, Antitubercular Phase 3
28 Antimetabolites Phase 3
29 Autonomic Agents Phase 2, Phase 3
30 Antitubercular Agents Phase 3
31 Calcium, Dietary Phase 2, Phase 3
32
Infliximab Approved Phase 1, Phase 2 170277-31-3
33 Mesalamine Phase 1, Phase 2 89-57-6
34 Analgesics Phase 1, Phase 2
35 Mitogens Phase 1, Phase 2
36 Analgesics, Non-Narcotic Phase 1, Phase 2
37 Anti-Inflammatory Agents Phase 1, Phase 2
38 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
39 Antirheumatic Agents Phase 1, Phase 2
40 Gastrointestinal Agents Phase 1, Phase 2
41 Dermatologic Agents Phase 1, Phase 2
42
Heparin Approved, Investigational 9005-49-6 772 46507594
43
Deferiprone Approved 30652-11-0 2972
44 Respiratory System Agents
45 calcium heparin
46 Pharmaceutical Solutions
47 Chelating Agents
48 Iron Chelating Agents
49 Xenon Early Phase 1

Interventional clinical trials:

(show all 25)

id Name Status NCT ID Phase Drugs
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome Recruiting NCT02408172 Phase 2, Phase 3 Amlodipine;metoprolol
3 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Recruiting NCT02430259 Phase 3 Weekly INH / RRT given by DOT
4 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
5 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
6 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
7 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
8 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Recruiting NCT02668068 Phase 1
9 Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Not yet recruiting NCT02790762 Phase 1
10 Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis Unknown status NCT02280343
11 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
12 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
13 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
14 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
15 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
16 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
17 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
18 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
19 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
20 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Recruiting NCT02794701
21 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693
22 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Recruiting NCT02596347
23 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Active, not recruiting NCT01284127
24 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
25 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1 HP 3He;HP 129Xe;PFP;SF6

Search NIH Clinical Center for Pneumoconiosis

Cochrane evidence based reviews: pneumoconiosis

Genetic Tests for Pneumoconiosis

Anatomical Context for Pneumoconiosis

MalaCards organs/tissues related to Pneumoconiosis:

39
Lung, Liver, Heart, Bone Marrow, Bone, Testes, Monocytes

Publications for Pneumoconiosis

Articles related to Pneumoconiosis:

(show top 50) (show all 632)
id Title Authors Year
1
The association of LAMB1 polymorphism and expression changes with the risk of coal workers' pneumoconiosis. ( 28444932 )
2017
2
A case of mixed dust pneumoconiosis with desquamative interstitial pneumonia-like reaction in an aluminum welder. ( 28239542 )
2017
3
Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. ( 28272360 )
2017
4
Element-based prognostics of occupational pneumoconiosis using micro-proton-induced X-ray emission analysis. ( 28912379 )
2017
5
Cross-section analysis of coal workers' pneumoconiosis and higher brachial-ankle pulse wave velocity within Kailuan study. ( 28148238 )
2017
6
Loss of regulatory characteristics in CD4(+) CD25(+/hi) T cells induced by impaired transforming growth factor beta secretion in pneumoconiosis. ( 28913840 )
2017
7
Wood charcoal dust pneumoconiosis. ( 28365221 )
2017
8
Evaluation of dental technician's pneumoconiosis using chest X-rayand HRCT: correlation between radiological and functional findings. ( 28263498 )
2017
9
Polymorphisms in autophagy related genes and the coal workers' pneumoconiosis in a Chinese population. ( 28844669 )
2017
10
LRBA Gene Polymorphisms and Risk of Coal Workers' Pneumoconiosis: A Case-Control Study from China. ( 28953250 )
2017
11
TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis. ( 28698801 )
2017
12
Progressive massive fibrosis in patients with pneumoconiosis: utility of MRI in differentiating from lung cancer. ( 28361545 )
2017
13
Daytime blood pressure surges following hypoxic episodes in a case of pneumoconiosis with lacunar stroke recurrences. ( 28263202 )
2017
14
Diagnostic and clinical application value of magnetic resonance imaging (MRI) for progressive massive fibrosis of coal worker pneumoconiosis: Case reports. ( 28514304 )
2017
15
Survival Analysis of Coal Workers' Pneumoconiosis (CWP) Patients in a State-Owned Mine in the East of China from 1963 to 2014. ( 28481235 )
2017
16
Increasing Severity of Pneumoconiosis Among Younger Former US Coal Miners Working Exclusively Under Modern Dust-Control Regulations. ( 28598937 )
2017
17
Association between Genetic Variants of Transforming Growth Factor-I^1 and Susceptibility of Pneumoconiosis: A Meta-analysis. ( 28139521 )
2017
18
Diagnostic accuracy of breath tests for pneumoconiosis using an electronic nose. ( 28795953 )
2017
19
Endobronchial fibroma in a pneumoconiosis patient with a history of tuberculosis: A case report and literature review. ( 27446391 )
2016
20
Risk factors associated with mortality from pneumonia among patients with pneumoconiosis. ( 27057317 )
2016
21
Coal workers' pneumoconiosis: an Australian perspective. ( 27318401 )
2016
22
Screening and Preliminary Verification of a Phage Display Single-Chain Antibody Library Against Coal Workers' Pneumoconiosis. ( 27930489 )
2016
23
Socio-Demographic and Clinical Characteristics of Turkish Workers with Pneumoconiosis. ( 27755862 )
2016
24
Risk of Cerebrovascular Events in Pneumoconiosis Patients: A Population-based Study, 1996-2011. ( 26945404 )
2016
25
Platelet Indices in Patients with Coal Workers' Pneumoconiosis. ( 27107875 )
2016
26
Pneumoconiosis in different sectors and their differences in Turkey. ( 28393716 )
2016
27
Dental technician pneumoconiosis mimicking pulmonary tuberculosis: a case report. ( 27604085 )
2016
28
Pneumoconiosis Redux. Coal Workers' Pneumoconiosis and Silicosis Are Still a Problem. ( 26977968 )
2016
29
Positive FDG PET/CT findings in a patient with pneumoconiosis. ( 28393722 )
2016
30
Lung transplantation is increasingly common among patients with coal workers' pneumoconiosis. ( 26725917 )
2016
31
Estimates and Predictions of Coal Workers' Pneumoconiosis Cases among Redeployed Coal Workers of the Fuxin Mining Industry Group in China: A Historical Cohort Study. ( 26845337 )
2016
32
Plasma LncRNA-ATB, a Potential Biomarker for Diagnosis of Patients with Coal Workers' Pneumoconiosis: A Case-Control Study. ( 27556453 )
2016
33
Ocular findings in coal miners diagnosed with pneumoconiosis. ( 27406957 )
2016
34
Differential gene expression associated with inflammation in peripheral blood cells of patients with pneumoconiosis. ( 27265534 )
2016
35
Emphysema and Airflow Obstruction in Non-Smoking Coal Miners with Pneumoconiosis. ( 27956734 )
2016
36
Japanese Workplace Health Management in Pneumoconiosis Prevention. ( 27980247 )
2016
37
Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers' Pneumoconiosis in a Chinese Population. ( 27626436 )
2016
38
Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population. ( 27621877 )
2016
39
The relation between the extent of radiological findings and respiratory functions in pneumoconiosis cases of dental technicians who are working in Ankara. ( 27481079 )
2016
40
Endogenous pneumoconiosis: Analytical scanning electron microscopic analysis of a case. ( 27281119 )
2016
41
Aluminum-induced pneumoconiosis confirmed by analytical scanning electron microscopy: A case report and review of the literature. ( 26895029 )
2016
42
Pneumoconiosis increases the risk of congestive heart failure: A nationwide population-based cohort study. ( 27336897 )
2016
43
Ocular findings in coal miners diagnosed with pneumoconiosis. ( 27292375 )
2016
44
Cost-Effectiveness of Coal Workers' Pneumoconiosis Prevention Based on Its Predicted Incidence within the Datong Coal Mine Group in China. ( 26098706 )
2015
45
Case cluster of pneumoconiosis at a coal slag processing facility. ( 25851166 )
2015
46
CT patterns of pleuro-pulmonary damage caused by inhalation of pumice as a model of pneumoconiosis from non-fibrous amorphous silicates. ( 26231253 )
2015
47
The association between bronchial anthracofibrosis and pneumoconiosis: A retrospective cross-sectional study. ( 25519805 )
2015
48
Fifty years ago: 'Emery Pneumoconiosis'. ( 26503973 )
2015
49
Prevalence Characteristics of Coal Workers' Pneumoconiosis (CWP) in a State-Owned Mine in Eastern China. ( 26184259 )
2015
50
Dental technician pneumoconiosis mimicking lung cancer. ( 26369493 )
2015

Variations for Pneumoconiosis

Expression for Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for Pneumoconiosis

Pathways related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 82)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.1 CASP8 CAT CCL2 CXCL8 FASLG IL1A
2
Show member pathways
13.92 CASP8 CCL2 CXCL8 FAS FASLG IL1A
3
Show member pathways
13.73 CASP8 CCL2 CXCL8 FAS FASLG IL1A
4
Show member pathways
13.56 CASP8 CXCL8 FAS FASLG IL1A IL1B
5
Show member pathways
13.49 CCL2 CXCL8 FAS FASLG IL1A IL1B
6
Show member pathways
13.43 CCL2 CXCL8 FASLG IL1A IL1B IL6
7
Show member pathways
13.37 CASP8 CCL2 CXCL8 FAS FASLG IL1A
8
Show member pathways
13.08 CASP8 CCL2 CXCL8 IL1A IL1B IL6
9
Show member pathways
12.97 CASP8 CCL2 FAS FASLG IL6 TNF
10
Show member pathways
12.92 CASP8 CCL2 CXCL8 FAS FASLG IL1B
11 12.81 CASP8 FAS FASLG HSPA1L IL1A IL1B
12
Show member pathways
12.81 CASP8 CXCL8 FAS FASLG HSPA1L IL1A
13
Show member pathways
12.79 CASP8 CXCL8 IL1B IL6 TNF
14 12.77 CASP8 CXCL8 FAS FASLG IL6 TGFB1
15
Show member pathways
12.76 IL1A IL1B IL6 TGFB1 TNF
16
Show member pathways
12.73 FAS FASLG IL1A IL1B TNF
17
Show member pathways
12.71 CASP8 FAS FASLG IL1A IL1B TNF
18
Show member pathways
12.67 IL1A IL1B IL6 TGFB1 TNF
19 12.62 CCL2 FAS FASLG IL1B TNF
20
Show member pathways
12.54 FAS IL1A IL1B IL6 TGFB1 TNF
21
Show member pathways
12.43 CASP8 CCL2 CXCL8 IL1B IL6 MUC5B
22
Show member pathways
12.38 CASP8 FAS FASLG TNF
23
Show member pathways
12.37 CXCL8 IL1A IL1B IL6 TNF
24
Show member pathways
12.37 CASP8 HSPA1L IL1A IL1B TGFB1 TNF
25 12.36 FAS FASLG TGFB1 TNF
26
Show member pathways
12.36 CASP8 FAS FASLG IL1A TNF
27 12.35 CASP8 IL1A IL1B IL6 TGFB1 TNF
28
Show member pathways
12.3 CXCL8 FAS FASLG IL1B IL6 TNF
29 12.29 CXCL8 IL1A IL1B IL6 TNF
30
Show member pathways
12.26 CXCL8 IL1A IL1B IL6 TNF
31 12.2 CCL2 GSTM1 IL1A IL1B TNF
32
Show member pathways
12.17 CAT FASLG IL6 TGFB1
33 12.15 FAS IL6 TGFB1 TNF
34 12.13 IL1A IL1B TGFB1 TNF
35 12.08 CASP8 CCL2 FAS IL1B IL6 TNF
36 12.08 CCL2 CXCL8 IL1A IL1B IL6 TGFB1
37 12.07 CXCL8 IL1A IL1B IL6 TGFB1
38
Show member pathways
12.06 CASP8 CCL2 CXCL8 FAS FASLG HSPA1L
39
Show member pathways
12.04 IL1B IL6 TGFB1 TNF
40 12.01 CXCL8 IL1B IL6 TGFB1 TNF
41 12 IL1A IL1B IL6 TNF
42
Show member pathways
11.94 IL1B IL6 TGFB1
43 11.94 CXCL8 IL1A IL1B IL6
44 11.91 CXCL8 IL1B TNF
45
Show member pathways
11.9 CXCL8 IL6 TGFB1
46 11.87 IL1B IL6 TGFB1 TNF
47 11.87 CXCL8 IL1A IL1B IL6 NLRP3 TNF
48
Show member pathways
11.86 CASP8 FAS FASLG
49
Show member pathways
11.86 FAS FASLG TNF
50 11.86 CCL2 CXCL8 IL1A IL1B IL6 TGFB1

GO Terms for Pneumoconiosis

Cellular components related to Pneumoconiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 CAT CCL2 CXCL8 FASLG IL1A IL1B
2 external side of plasma membrane GO:0009897 9.71 FAS FASLG IL6 TNF
3 membrane raft GO:0045121 9.67 CASP8 FAS FASLG TNF
4 extracellular region GO:0005576 9.47 CAT CCL2 CXCL8 FAS FASLG IL1A
5 secretory granule GO:0030141 9.46 IL1B SCGB1A1 SOD1 TGFB1
6 death-inducing signaling complex GO:0031264 9.32 CASP8 FAS
7 CD95 death-inducing signaling complex GO:0031265 9.26 CASP8 FAS

Biological processes related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.99 FAS IL1B TGFB1 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.98 CCL2 IL1A IL1B IL6
3 cellular response to lipopolysaccharide GO:0071222 9.96 CCL2 CXCL8 IL6 NLRP3 TNF
4 response to ethanol GO:0045471 9.95 CASP8 CAT CCL2 OGG1 SOD1
5 response to drug GO:0042493 9.95 CAT CCL2 IL6 OGG1 SCGB1A1 SOD1
6 positive regulation of protein kinase B signaling GO:0051897 9.93 IL6 TGFB1 TNF
7 aging GO:0007568 9.93 CAT CCL2 IL6 OGG1 SOD1 TGFB1
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.92 IL6 TGFB1 TNF
9 response to estradiol GO:0032355 9.92 CASP8 CAT OGG1 TGFB1
10 response to organic substance GO:0010033 9.92 SCGB1A1 SOD1 TGFB1 TNF
11 immune response GO:0006955 9.92 CCL2 CXCL8 FAS FASLG IL1A IL1B
12 response to wounding GO:0009611 9.91 CCL2 IL6 TGFB1
13 cellular response to interleukin-1 GO:0071347 9.91 CCL2 CXCL8 IL6
14 neutrophil chemotaxis GO:0030593 9.91 CCL2 CXCL8 IL1B
15 cellular response to mechanical stimulus GO:0071260 9.91 CASP8 FAS IL1B TGFB1
16 apoptotic signaling pathway GO:0097190 9.9 CASP8 FAS FASLG TNF
17 humoral immune response GO:0006959 9.89 CCL2 IL6 TNF
18 T cell activation GO:0042110 9.89 CASP8 IL6 TGFB1
19 response to heat GO:0009408 9.88 CCL2 IL6 SOD1
20 positive regulation of interleukin-6 production GO:0032755 9.88 IL1A IL1B IL6 TNF
21 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.88 CASP8 FAS FASLG NLRP3 TNF
22 negative regulation of fat cell differentiation GO:0045599 9.87 IL6 TGFB1 TNF
23 positive regulation of cell division GO:0051781 9.87 CAT IL1A IL1B TGFB1
24 embryo implantation GO:0007566 9.86 IL1B SCGB1A1 SOD1
25 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 IL1B IL6 TNF
26 response to radiation GO:0009314 9.84 CAT OGG1 TGFB1
27 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.83 IL1A IL1B TNF
28 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.83 CASP8 FAS FASLG
29 response to antibiotic GO:0046677 9.83 CASP8 CCL2 IL6 SOD1
30 cellular response to organic cyclic compound GO:0071407 9.83 CASP8 CCL2 IL1B TGFB1 TNF
31 cellular response to dexamethasone stimulus GO:0071549 9.82 CCL2 IL6 TGFB1
32 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.81 FAS IL1A IL1B
33 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.81 FAS FASLG TNF
34 protein kinase B signaling GO:0043491 9.81 CCL2 IL1B TGFB1 TNF
35 positive regulation of vascular endothelial growth factor production GO:0010575 9.8 IL1A IL1B TGFB1
36 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 CCL2 IL1B TGFB1 TNF
37 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.78 CASP8 FAS FASLG
38 response to glucocorticoid GO:0051384 9.77 CCL2 FAS IL6 SCGB1A1 TNF
39 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.76 CASP8 FAS FASLG
40 cellular response to ATP GO:0071318 9.75 CCL2 SOD1
41 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.75 IL1B TNF
42 positive regulation of superoxide anion generation GO:0032930 9.75 SOD1 TGFB1
43 PERK-mediated unfolded protein response GO:0036499 9.75 CCL2 CXCL8
44 response to reactive oxygen species GO:0000302 9.75 CAT SOD1
45 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.75 IL1A IL1B
46 positive regulation of chemokine biosynthetic process GO:0045080 9.74 IL1B TNF
47 myeloid cell homeostasis GO:0002262 9.74 IL6 SOD1
48 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.74 IL1A IL1B
49 negative regulation of lipid storage GO:0010888 9.73 IL6 TNF
50 death-inducing signaling complex assembly GO:0071550 9.73 CASP8 TNF

Molecular functions related to Pneumoconiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL2 CXCL8 FASLG IL1A IL1B IL6
2 tumor necrosis factor receptor binding GO:0005164 9.13 CASP8 FASLG TNF

Sources for Pneumoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....