Summaries for Pneumonia

Sources:
6Disease Ontology, 23MedlinePlus, 44Wikipedia, 22MalaCards
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MedlinePlus: Pneumonia is an inflammation of the lung, usually caused by an infection. three common causes are bacteria, viruses and fungi. you can also get pneumonia by accidentally inhaling a liquid or chemical. people most at risk are older than 65 or younger than 2 years of age, or already have health problems. if you have pneumonia, you may have difficulty breathing and have a cough and a fever. a physical exam and history can help determine if you have pneumonia. chest x-rays and blood tests can help determine what is wrong. treatment depends on what made you sick. if bacteria are the cause, antibiotics should help. viral pneumonia may get better with rest and drinking liquids. preventing pneumonia is always better than treating it. the best preventive measures include washing your hands frequently, not smoking, and wearing a mask when cleaning dusty or moldy areas. there is a vaccine for pneumococcal pneumonia, a bacterial infection which accounts for up to a quarter of all pneumonias.23

MalaCards: Pneumonia, also known as acute pneumonia, is related to tuberculosis and carcinoma. An important gene associated with Pneumonia is CRP (C-reactive protein, pentraxin-related), and among its related pathways are Metabolic pathways and Antioxidant Action of Vitamin-C. The drugs sucralfate and acetylcysteine and the compounds calcium and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and lung, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Disease Ontology: A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). it results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. it is accompanied by fever, chills, cough, and difficulty in breathing.6

Wikipedia: Pneumonia is an inflammatory condition of the lung—affecting primarily the microscopic air sacs known...44 more...

Aliases & Descriptions for Pneumonia

Sources:
2CDC, 6Disease Ontology, 8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS, 7diseasecard, 40SNOMED-CT, 24MeSH, 27NCIt
See all sources

Aliases & Descriptions:

pneumonia 6 8 32 23 43
acute pneumonia 6 43
pneumonitis 6 7

Related Diseases for Pneumonia

Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to pneumonia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 984)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis147.9COASY, RELA, REV1, CNDP1, CNDP2, CNNM1
2carcinoma128.1PIGR, PIK3C2A, PI3, KL, PDE4A, RELA
3leukemia106.3PIK3C2A, COG2, PDE4A, RELA, REV1, VTN
4neuronitis92.8PIK3C2A, PDE4A, RELA, CNDP1, CNNM1, CNNM2
5pancreatitis90.8PIK3C2A, PI3, KL, PDE4A, RELA, VTN
6fibrosis89.6PI3, KL, PDE4A, RELA, VTN, SFTPA1
7rheumatoid arthritis87.0KL, PDE4A, RELA, CNDP2, VTN, SFTPD
8colorectal cancer81.1PIGR, SH2D3A, COG2, KL, CNNM4, VPS13B
9melanoma78.6PIK3C2A, PI3, KL, PDE4A, RELA, VTN
10atherosclerosis77.3PIK3C2A, PI3, COG2, KL, PDE4A, VTN
11malaria73.9COASY, PDE4A, CNNM1, CNNM2, CNNM3, CNNM4
12cholesterol73.5PIK3C2A, COG2, KL, KLB, RELA, VTN
13lupus erythematosus69.6PIK3C2A, COG2, VTN, RDBP, SFTPD, RBP4
14cerebritis69.4PIK3C2A, COG2, PDE4A, RELA, VTN, RBP4
15cystic fibrosis68.3PI3, PDE4A, SFTPA1, SFTPB, SFTPC, SFTPD
16diabetes mellitus68.2PIK3C2A, PI3, COG2, PDE4A, CNDP1, CNDP2
17influenza68.0PIGR, PIK3C2A, RELA, VTN, SFTPA1, SFTPD
18peritonitis67.0PIK3C2A, COG2, RELA, VTN, RBP4, SELE
19multiple sclerosis66.6PDE4A, RELA, VTN, BTN1A1, SELE, SELL
20pulmonary disease65.8PI3, PDE4A, SFTPA1, SFTPB, SFTPC, SFTPD
21hypertension63.4PIK3C2A, COG2, KL, PDE4A, CNNM2, SFTPB
22anemia60.8RELA, REV1, SELE, SELL, SERPINC1, SETD2
23bronchiolitis60.3PIK3C2A, SFTPA1, SFTPB, SFTPC, SFTPD, SELE
24myeloma59.5PDE4A, RELA, VTN, RBP4, SELL, SERPINC1
25pulmonary fibrosis59.4VTN, SFTPA1, SFTPB, SFTPC, SFTPD, SELE
26prostatitis59.3PIK3C2A, KL, PDE4A, RELA, CNDP2, CNNM3
27sepsis58.2PI3, PDE4A, VTN, SFTPD, RBP4, SELE
28gingivitis57.9BTK, SELE, SELL, SETD2, SERPINF2, SERPINH1
29meningitis57.4PIK3C2A, BTK, SELE, SELL, SERPINA1, VIM
30gonococcal synovitis55.7PIGR, PI3, PDE4A, RELA, VTN, SFTPB
31blindness54.7PIK3C2A, COG2, PDE4A, RBP4, SELE, SERPINC1
32lung carcinoma54.7SFTPB, SFTPD, RBP4, SELL, SETD2, SERPINA1
33sarcoidosis54.5PIK3C2A, VTN, SFTPD, SELE, SELL, VIM
34multiple myeloma53.0RELA, VTN, RBP4, SERPINC1, SETD2, NAGLU
35lymphoblastic leukemia52.8COG2, RELA, SFTPD, BTK, SELL, SERPINC1
36coronary heart disease52.5PIK3C2A, COG2, CNDP1, SELE, SELL, SERPINC1
37herpes simplex52.2SERPINC1, SERPINE1, VIM, VEGFA, LPO, MYD88
38adenocarcinoma51.7PIGR, PIK3C2A, RELA, REV1, VTN, SFTPB
39copd51.0PIK3C2A, PDE4A, RELA, SFTPB, SFTPD, SELL
40nasopharyngitis50.7PIGR, RELA, SETD2, SERPINB9, VIM, VEGFA
41klebsiella48.8SFTPD, SERPINC1, VDAC1, LCN2, MTAP, LACTB
42systemic lupus erythematosus48.8VTN, RBP4, SELE, SERPINH1, SERPINB1, VCAM1
43gastric cancer48.2COASY, RELA, WARS2, VTN, SELE, SELL
44aortic aneurysm47.3PIK3C2A, SELE, SELL, SERPINC1, SERPINF2, SERPINE1
45purpura47.0SELE, SERPINC1, SERPINF2, SERPINE1, VEGFA, VCAM1
46alzheimer's disease46.5COG2, PDE4A, CNNM1, CNNM2, SFTPA1, SFTPC
47otitis media46.4SFTPA1, SELL, SERPINC1, SERPINE1, VCAM1, MYD88
48dementia46.3PIK3C2A, PDE4A, SFTPD, SERPINC1, SERPINA1, SERPINE1
49thyroiditis46.1PIK3C2A, COG2, PDE4A, RELA, VTN, SFTPA1
50nephritis46.0VTN, RBP4, SELE, SERPINA1, SERPINE1, NAGLU

Graphical network of the top 20 diseases related to pneumonia:



Graphical network of diseases related to pneumonia

Clinical Features for Pneumonia

Drugs & Therapeutics for Pneumonia

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for pneumonia

Drug clinical trials:

Search ClinicalTrials for pneumonia

Search NIH Clinical Center for pneumonia

Search CenterWatch for pneumonia

Inferred drug relations via UMLS/NDF-RT:

43 28 acetylcysteine, oxygen, sparfloxacin, sucralfate

Genetic Tests for Pneumonia

Anatomical Context for Pneumonia

Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to pneumonia:

22
Brain, Liver, Lung, Bone marrow, Whole blood, Thymus, Heart, Smooth muscle, Colon, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Bronchial epithelium, Pancreatic islet

Phenotypes for genes affiliated with Pneumonia

Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to pneumonia:

25 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1homeostasis/metabolism phenotypeMP:000537648.7PIGR, PIK3C2A, PILRB, KL, KLB, RELA
2mortality/agingMP:001076841.2PIK3C2A, PILRB, KL, RELA, REV1, SFTPB
3cellular phenotypeMP:000538440.4KL, RELA, REV1, BTK, RBP4, SELE
4cardiovascular system phenotypeMP:000538533.1KL, PDE4A, RELA, SFTPC, BTAF1, RBP4
5immune system phenotypeMP:000538733.0PIGR, PILRB, KL, PDE4A, REV1, BTK
6growth/size phenotypeMP:000537832.4PIK3C2A, KL, KLB, RELA, REV1, SFTPC
7behavior/neurological phenotypeMP:000538629.4KL, SFTPB, SFTPC, PCCA, SELE, VIM
8nervous system phenotypeMP:000363128.3KL, PDE4A, RELA, BTAF1, SERPINC1, SERPINH1
9hematopoietic system phenotypeMP:000539726.4PIGR, REV1, BTK, SERPINB9, SERPINB1, MYD88
10reproductive system phenotypeMP:000538925.0PIGR, SFTPC, BTN1A1, RBP4, VEGFA, VASN
11normal phenotypeMP:000287323.4RELA, REV1, VTN, RBP4, SELE, VEGFA
12muscle phenotypeMP:000536923.2KL, RELA, BTAF1, RBP4, VIM, VEGFA
13integument phenotypeMP:001077121.6KL, RELA, PCCA, BTK, BTN1A1, RAC1
14digestive/alimentary phenotypeMP:000538121.4PIGR, KL, BTK, VEGFA, MYLK, RARA
15tumorigenesisMP:000200621.4SFTPC, BTK, SELL, SERPINE1, MYD88, RARA
16vision/eye phenotypeMP:000539120.6RELA, SFTPC, RBP4, SELE, SERPINC1, VIM
17endocrine/exocrine gland phenotypeMP:000537919.0KL, KLB, BTN1A1, SELL, LDHC, LDLR
18skeleton phenotypeMP:000539018.4RELA, NAGLU, VEGFA, MYD88, BMP6, RARA
19liver/biliary system phenotypeMP:000537018.3KLB, PCCA, SERPINC1, VEGFA, LPL, VASN
20respiratory system phenotypeMP:000538818.1KL, SFTPC, SFTPD, SELL, SERPINB1, LPL
21renal/urinary system phenotypeMP:000536717.8KL, PCCA, NAGLU, MYD88, MYLK, RARA
22embryogenesis phenotypeMP:000538017.3BTAF1, SERPINC1, SETD2, VIM, RAD51, RAD54L2
23craniofacial phenotypeMP:000538215.7BTAF1, NAGLU, BDNF, LAMP1, CFTR, ATP2C1
24adipose tissue phenotypeMP:000537515.7PIK3C2A, KL, SERPINE1, LPL, MYD88, LIF
25other phenotypeMP:000539513.7KL, SERPINH1, RARA, LDLR, LAMC2, ATP7B

Publications for genes affiliated with Pneumonia

Sources:
35PubMed
See all sources

Articles related to pneumonia:

(show top 50)    (show all 1103)
idTitleAuthorsYearAffiliating Genes
1Heat shock protein 10 of Chlamydophila pneumoniae ind uces proinflammatory cytokines through Toll-like receptor (TLR) 2 and TLR4 in h uman monocytes THP-1. (21789730)Zhou Z.... Chen C.2011TLR2, TLR4
2Decreased interleukin-18 response in asthmatic childr en with severe Mycoplasma pneumoniae pneumonia. (21356600)Chung H.L.... Kim S.G.2011IL18
3Serum levels of IL-13 and TNF-alpha in children with Mycoplasma pneumoniae pneumonia (20416219)Li Y.F.... Lu Z.F.2010TNF, IL13
4Streptococcus pneumoniae DNA load in blood as a marke r of infection in patients with community-acquired pneumonia. (19675218)Peters R.P.... Savelkoul P.H.2009CRP
5Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats. (19740417)Hofstra J.J.... Schultz M.J.2009SERPINC1, F5
6Community-acquired pneumonia in older patients: does age influence systemic cytokine levels in community-acquired pneumonia? (19272082)Kelly E.... O'Neill S.J.2009IL6, IL10
7C-reactive protein, severity of pneumonia and mortali ty in elderly, hospitalised patients with community-acquired pneumonia. (19729453)Thiem U.... Pientka L.2009CRP
8Transient acquired hemophilia associated with Mycoplasma pneumoniae pneumonia. (18303215)Kim M.S.... Hwang P.H.2008F8
9Pneumocystis jirovecii pneumonia in Spanish HIV-infected patients in the combined antiretroviral therapy era: prevalence of dihydropteroate synthase mutations and prognostic factors of mortality. (18554841)Alvarez-Martinez M.J.... Meshnick S.R.2008DHPS
10Validity of the quick-read C-reactive protein test in the prediction of bacterial pneumonia in the pediatric emergency department. (18460957)Marcus N.... Waisman Y.2008CRP
11Immunoproteomic identification and serological responses to novel Chlamydia pneumoniae antigens that are associated with persistent C. pneumoniae infections. (18390732)Bunk S.... Hermann C.2008HSPD1
12A patient with fulminant influenza-related bacterial pneumonia due to Streptococcus pneumoniae followed by Mycobacterium tuberculosi s infection. (19043258)Seki M.... Kohno S.2008ELANE
13Efficient replication of pneumonia virus of mice (PVM) in a mouse macrophage cell line. (17547763)Dyer K.D.... Rosenberg H.F.2007TNF, IL8, CCL4
14Leptospiral pneumonias. (17414132)Dolhnikoff M.... Carvalho C.R.2007SLC5A6
15Tuberculosis and Legionella pneumophila pneumonia in a patient receiving anti-tumour necrosis factor-alpha (anti-TNF-alpha) treatment. (17711485)Mancini G.... Vullo V.2007TNF
16Septic arthritis due to extended spectrum beta lactamase producing Klebsiella pneumoniae. (17433752)Schelenz S.... Goldsmith D.2007LACTB
17Emergence of a Streptococcus pneumoniae isolate resistant to streptogramins by mutation in ribosomal protein L22 during pristinamycin therapy of pneumococcal pneumonia. (17434877)Cattoir V.... Leclercq R.2007RPL22, RPL4
18H3N2 subtype of human influenza pneumonia with staph ylococcal sepsis and staphylococcal pneumonia: report of one case (18087564)Mu X.D.... Que C.L.2007NEU1
19Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. (17334246)Angus D.C.... Weissfeld L.2007HMGB1
20In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase. (16652304)Elliott E.... Livermore D.M.2006LACTB
21The relationship between serum endothelin (ET)-1 and wheezing status in the children with Mycoplasma pneumoniae pneumonia. (16771782)Chung H.L.... Shin I.H.2006EDN1
22Chlamydia pneumoniae and Mycoplasma pneumoniae pneumo nia: comparison of clinical, epidemiological characteristics and laboratory pro files. (16316495)Puljiz I.... Mise B.2006CRP
23Usefulness of procalcitonin levels in community-acquired pneumonia according to the patients outcome research team pneumonia severity index. (16236878)Masia M.... Hernandez I.2005CALCA
24Expression of HSP47 in usual interstitial pneumonia and nonspecific interstitial pneumonia. (15955241)Kakugawa T.... Kohno S.2005SERPINH1
25Non-specific host response markers in the differentiation between pneumococcal and viral pneumonia: what is the most accurate combination? (15491381)Korppi M.2004CRP
26High-BAL fluid concentrations of RANTES in nonspecific interstitial pneumonia compared with usual interstitial pneumonia. (15481270)Yoshioka S.... Kohno S.2004CCL2
27Nonspecific interstitial pneumonia and usual interstitial pneumonia with mutation in surfactant protein C in familial pulmonary fibrosis. (15133475)Chibbar R.... Lemire E.G.2004SFTPC
28Different cytokine profiles in usual interstitial pneumonia and nonspecific interstitial pneumonia (12899768)Gu L.... Zhu Y.J.2003TGFB1, FGF2, IL8
29Elevated interleukin-6 predicts progressive carotid artery atherosclerosis in dialysis patients: association with Chlamydia pneumoniae seropositivity. (11840367)Stenvinkel P.... Jogestrand T.2002IL6
30Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis. (12526080)Choi E.Y.... Kim H.S.2002BSG
31Linezolid for the treatment of community-acquired pneumonia in hospitalized children. Linezolid Pediatric Pneumonia Study Group. (11368105)Kaplan S.L.... Anderson D.C.2001GPT
32Remission of acute myeloblastic leukemia after severe pneumonia treated with high-dose methylprednisolone. (11594518)Shimohakamada Y.... Fukuda N.2001RUNX1T1
33Two cases of lymphadenopathy with liver dysfunction due to Mycoplasma pneumoniae infection with mycoplasmal bacteraemia without pneumonia. (11531323)Narita M.... Sageshima S.2001MSH2
34Increased levels of interleukin-6 are associated with lymphocytosis in bronchoalveolar lavage fluids of idiopathic nonspecific interstitial pneumonia. (10988147)Park C.S.... Kitaichi M.2000IL6
35Intracellular trafficking and killing of Streptococcus pneumoniae by human alveolar macrophages are influenced by opsonins. (10722631)Gordon S.B.... Read R.C.2000LAMP3
36Immunoglobin subclasses and determination of specific antibodies. What role in the study of children with recurrent pneumonias? (11234492)De Sousa P.O.... Trindade J.C.2000CD79A
37Cellular immune response to Klebsiella pneumoniae antigens in patients with HLA-B27+ ankylosing spondylitis. (10852270)DomA-nguez-LA^pez M.L.... GarcA-a-Latorre E.2000HSPD1
38Serologic and histopathologic study of Chlamydia pneumoniae infection in atherosclerosis: a possible pathogenetic mechanism of atherosclerosis induced by Chlamydia pneumoniae. (10957885)Song Y.G.... Kim H.S.2000MMP9, PTGS2
39Identification of human beta-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia. (9731241)Hiratsuka T.... Matsukura S.1998DEFB4A
40Comparative study of the clinical presentation of Leg ionella pneumonia and other community-acquired pneumonias. (9596294)Sopena N.... Tudela P.1998CHKB
41Predominant implication of IL-5 in acute eosinophilic pneumonia: comparison with chronic eosinophilic pneumonia. (9623513)Okubo Y.... Sekiguchi M.1998IL5
42A case of Goodpasture's syndrome with myeloperoxidase specific anti-neutrophil cytoplasmic autoantibody (MPO-ANCA) during chronic interstitial pneumonia (9567081)Inoue A.... Ono Y.1997MPO
43IL-1beta and IL-6 in community-acquired pneumonia: bacteremic pneumococcal pneumonia versus Mycoplasma pneumoniae pneumonia. (9108183)Lieberman D.... Levy R.1997IL6, IL1B
44Modified latex agglutination test for rapid detection of Streptococcus pneumoniae and haemophilus influenzae in cerebrospinal fluid and direct serotyping of Streptococcus pneumoniae. (8839641)Singhal A.... Steinhoff M.C.1996HLA-B
45Adhesion molecules on eosinophils in acute eosinophilic pneumonia. (7697263)Okubo Y.... Takatsu K.1995IL5
46Interleukin-8 and eicosanoid production in the lung during moderate to severe Pneumocystis carinii pneumonia in AIDS: a role of interleukin-8 in the pathogenesis of P. carinii pneumonia. (7597268)Benfield T.L.... Lundgren J.D.1995IL8, PLA2G1B
47Increased adenosine deaminase activity in Q fever pneumonia with pleural effusion. (8306800)Esteban C.... Capelastegui A.1994ADA
48Interleukin-8 and granulocyte colony-stimulating factor in bronchoalveolar lavage fluid and plasma of human immunodeficiency virus-infected patients with Pneumocystis carinii pneumonia, bacterial pneumonia, or tuberculosis. (7690822)GrA1newald T.... Ruf B.1993IL8
49Local production of interleukin-8 is associated with nosocomial pneumonia. (1635109)Rodriguez J.L.... Remick D.G.1992IL8
50Detection of Streptococcus pneumoniae and Haemophilus influenzae type b antigens in the serum and urine of patients with pneumonia i n Papua New Guinea: comparison of latex agglutination and counterimmunoelectrop horesis. (2270396)Witt C.S.... Alpers M.P.1990HLA-B

Expression for genes affiliated with Pneumonia

Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Pneumonia

Pathways for genes affiliated with Pneumonia

Sources:
20KEGG, 36QIAGEN, 41Thomson Reuters, 37R&D Systems, 10EMD Millipore
See all sources

Pathways related to pneumonia according to GeneDecks:

(show top 50)    (show all 138)
idPathwayScoreTop Affiliating Genes
1Metabolic pathways2035.7PIK3C2A, COASY, KL, CNDP1, PCCA, GCH1
2Antioxidant Action of Vitamin-C3623.4BTK, VEGFC, BMP6, RAC1, LIF, BDNF
3Tec Kinases Signaling3622.7BTK, VEGFC, MYD88, BMP6, RAC1, PAK4
4Cytokine-cytokine receptor interaction2022.0VEGFA, VEGFC, LIF, CD40LG, CD40, FLT3LG
5p38 Signaling3622.0BTK, VEGFC, BMP6, RAC1, LIF, BDNF
6Rho Family GTPases3621.0BTK, VIM, VEGFC, MYLK, BMP6, RAC1
7STAT3 Pathway3620.7BTK, BMP6, RAC1, LIF, BCL2, CD4
8MAPK Family Pathway3620.3BTK, VEGFC, BMP6, RAC1, BDNF, BCL2
9Molecular Mechanisms of Cancer3620.1BTK, VEGFC, BMP6, RARA, LIF, BIRC3
10Akt Signaling3620.0BTK, VEGFC, LIF, CHUK, CD4, ITGAM
11JAK-STAT Pathway3619.8BTK, VEGFC, BMP6, BDNF, BCL2, JUN
12ERK Signaling3619.8BTK, VEGFC, MYLK, BMP6, PAK4, CHUK
13PAK Pathway3619.7BTK, VEGFC, MYLK, BMP6, RAC1, LIF
14MIF Regulation of Innate Immune Cells3619.2BTK, BMP6, LIF, BCL2, JUN, CD14
15TGF-Beta Pathway3618.7BTK, VEGFC, BMP6, BDNF, BCL2, JUN
16MIF Mediated Glucocorticoid Regulation3618.7BTK, BMP6, LIF, BCL2, CD14, MIF
17PEDF Induced Signaling3618.6RELA, BTK, BMP6, LIF, BDNF, BCL2
18Transendothelial Migration of Leukocytes3618.6BTK, VCAM1, MYLK, RAC1, CLDN5, PAK4
19all-trans-Retinoic Acid Signaling in Brain3618.2BTK, BMP6, RARA, LIF, BCL2, IL10
20Glucocorticoid Receptor Signaling3617.8BTK, BMP6, BCL2, JUN, CD4, IL10
21Endothelin-1 Signaling Pathway3617.2BTK, BMP6, IL10, IL11, IL13, IL16
22Chemokine Signaling3617.1JUN, IL8, MAPK8, MAPK3, MAPK1, CCL4
23Regulation of eIF4 and p70S6K3616.9BTK, VEGFC, CD4, ITGA4, ITGAM, ITGB2
24SOCS Pathway3616.6BTK, VEGFC, BMP6, BCL2, CD4, INS
25IL-6 Pathway3616.4BTK, BMP6, IL10, IL11, IL16, IL18
26Chemokine signaling pathway2016.4RELA, RAC1, CHUK, CDC42, ITK, IL8
27RAR-Gamma-RXR-Alpha Degradation3616.2BTK, LIF, IL11, IL15, IL16, IL2
28PGC1Alpha Pathway3616.1BTK, BMP6, BCL2, CD4, IL11, IL13
29Toll-like receptor signaling pathway2016.0RELA, MYD88, RAC1, CHUK, LBP, JUN
30NFAT Signaling and Lymphocyte Interactions3615.8BTK, BMP6, BCL2, CD3D, CD4, FCER2
31Influenza A2015.8RELA, VDAC1, MYD88, JUN, IRF3, IRF7
32Tuberculosis2015.6RELA, MYD88, BCL2, LBP, LAMP1, ATP6V0B
33Purine metabolism2015.4PDE4A, PAICS, XDH, ATIC, ITPA, GUK1
34Rheumatoid arthritis2015.3VEGFA, ATP6V1B1, ATP6V1D, ATP6V1B2, ATP6V1A, ATP6V0B
35NF-KappaB Family Pathway3615.3RELA, VEGFC, MYD88, BMP6, BDNF, CHUK
36NF-KappaB (p50-p65) Pathway3615.1RELA, VEGFC, MYD88, BMP6, BDNF, CHUK
37Hematopoietic cell lineage2014.8MS4A1, CD36, CD3D, CD8A, CD14, CD4
38Pertussis2014.7RELA, SFTPA1, MYD88, JUN, CD14, ITGAM
39Immune response_TLR signaling pathways4114.4RELA, SFTPA1, MYD88, CHUK, LBP, JUN
40Glycolysis / Gluconeogenesis2014.4BPGM, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC
41Malaria2014.4SELE, VCAM1, MYD88, CD36, CD40LG, CD40
42Toll-Like Receptor Signaling Pathways3714.0RELA, MYD88, CHUK, JUN, CD36, CD14
43TRAF Pathway3613.7MYD88, BIRC3, CHUK, JUN, IL1A, IL1B
44Complement and coagulation cascades2013.7SERPINC1, SERPINF2, SERPINA1, SERPINE1, CFH, CFI
45Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response1013.6MYD88, CHUK, LBP, JUN, CD14, IL11
46Bacterial infections in CF airways4113.4RELA, SFTPA1, SFTPD, MYD88, CHUK, MUC1
47Toll-Like Receptors Pathway3613.3BTK, MYD88, RAC1, CHUK, LBP, JUN
48Immune response_Bacterial infections in normal airways4113.3RELA, MYD88, CHUK, LBP, CFTR, CD14
49Pyrimidine metabolism2012.9UMPS, UCK2, CDA, ITPA, CAD, AK3
50Pathways in cancer2012.5RELA, VEGFA, VEGFC, RAD51, RARA, RAC1

Compounds for genes affiliated with Pneumonia

Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
See all sources

Compounds related to pneumonia according to GeneDecks:

(show top 50)    (show all 544)
idCompoundScoreTop Affiliating Genes
1calcium32 9 18 9 48.0PIGR, PIK3C2A, PI3, COG2, KL, PDE4A
2nitric oxide32 9 18 9 37.1COG2, PDE4A, SFTPB, SFTPD, GCH1, SELE
3atp32 32.2PIK3C2A, PDE4A, WARS2, VTN, SFTPB, PCCA
4cysteine32 28.8PI3, VTN, SFTPB, SFTPC, SFTPD, BTK
5cholesterol32 9 18 9 31.1PIK3C2A, COG2, VTN, SFTPB, SFTPC, SFTPD
6superoxide32 18 28.3PIK3C2A, PI3, PDE4A, GCH1, SELL, SETD2
7iron32 18 23.1PIK3C2A, COG2, RBP4, SETD2, SERPINA1, VIM
8indomethacin32 9 9 22.9PDE4A, SELL, VIM, LPL, BMP6, BDNF
9paraffin32 20.4RELA, SFTPB, SELL, SERPINA1, VIM, VEGFA
10glucose32 20.2PDE4A, GCH1, SETD2, VEGFC, LPO, LMAN1
11norepinephrine32 9 18 9 23.0PIK3C2A, PDE4A, GCH1, SELE, SELL, LPL
12ethanol32 34 9 18 9 23.8KL, SFTPC, SERPINA1, BPI, VAT1, BDNF
13neopterin32 18.5GCH1, NAGLU, CHKB, LCN2, SAA4, B2M
14acetylcholine32 9 18 9 21.2PIK3C2A, PDE4A, VIM, LPL, BMP6, RAC1
15progesterone32 42 9 18 9 21.6PDE4A, SFTPB, RBP4, SETD2, BSG, VEGFC
16methionine32 17.5SFTPC, GCH1, SERPINH1, SERPINA1, VIM, LPO
17peptidoglycan32 16.5VDAC1, MYD88, CHUK, LBP, ATN1, CD14
18heparan sulfate32 18 17.5VTN, SERPINC1, SERPINF2, SERPINE1, VIM, BSG
19urea32 9 18 9 19.2PIK3C2A, VTN, SERPINF2, NAGLU, BPI, RAD51
20dopamine32 9 18 9 19.1PDE4A, GCH1, RBP4, SELE, NAGLU, BMP6
21glyceraldehyde 3-phosphate32 16.0SETD2, VEGFC, VDAC1, UNG, CKB, LDHA
22tamoxifen32 34 9 9 18.8PDE4A, VTN, SELE, SERPINC1, SERPINB9, VIM
23calcitriol32 42 9 18 9 19.5BMP6, RARA, LIF, BGLAP, LBP, S100A8
24malondialdehyde32 15.4PIK3C2A, COG2, NAGLU, CHKA, CHKB, XDH
255fluorouracil32 15.2SELE, VEGFA, LIF, BIRC3, BCL2, UNG
26nadph32 18 16.1GCH1, NADK, LPO, MYD88, ASS1, MGMT
27histidine32 15.0PDE4A, BPGM, RAD51, RARA, MVK, LALBA
28carbon32 14.7VTN, SFTPD, LPL, BCHE, LDLR, MTHFR
29chloroquine32 34 9 9 17.7VTN, SERPINC1, BMP6, LDLR, B2M, CFTR
30cytochalasin d32 42 15.6VTN, SELE, SELL, VIM, LPL, VCAM1
31manganese superoxide32 14.6SFTPB, VCAM1, CD14, CD40, GSR, GSTM1
32agar32 14.3VIM, VDAC1, RARA, RAC1, MUC1, MTAP
33ribavirin32 34 9 9 17.3CD40LG, ITPA, MMP1, MMP2, MMP9, IMPDH1
34gf 109203x32 42 15.2BTK, VEGFA, CFTR, JUN, MMP1, FN1
35procollagen32 14.0SERPINH1, VIM, BMP6, CMA1, BGLAP, CFP
36anaphylatoxin32 14.0CFP, MPO, IL1B, IL3, IL4, IL6
37anti-fungal32 14.0SFTPD, BPI, MUC7, CD79A, CD40LG, IL15
38salicylic acid32 13.5SERPINA1, LPO, CHUK, XDH, CFTR, CD40
39ionomycin32 13.4BTK, SETD2, CHUK, ATP2A3, CD69, CD40
40phosphatidylserine32 9 9 15.4SELE, VIM, LPL, RAC1, BCL2, LALBA
41troglitazone32 42 9 9 16.3SELE, SERPINE1, LPL, VCAM1, BMP6, RARA
42melphalan32 9 9 15.1PIK3C2A, RAD51, CHKB, MUC16, CD79A, MMP2
43sulfasalazine32 9 9 14.7SELE, CHUK, MTHFR, MPO, CD79A, CD40LG
44succinate32 12.7SELE, SETD2, VDAC1, CHKB, MT-CYB, B2M
45budesonide32 42 9 9 15.6PDE4A, SFTPD, BGLAP, CD36, CCL11, IGHE
46vincristine32 34 9 9 15.5BTK, BCL6, ITGA4, MGMT, FGF2, ANXA5
47mifepristone32 42 9 9 15.4PI3, LIF, MUC1, JUN, MMP1, MMP3
48pioglitazone32 9 9 14.1COG2, RBP4, BSG, VEGFA, LPL, VCAM1
49fluorescein32 9 9 13.8SERPINC1, VEGFA, BGLAP, LALBA, MPO, CD40LG
50silymarin32 11.5VEGFA, BMP6, CHUK, XDH, JUN, MMP2

GO Terms for genes affiliated with Pneumonia

Sources:
12Gene Ontology
See all sources

Cellular components related to pneumonia according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573738.1PIK3C2A, COASY, RELA, GCH1, BTK, SERPINB9
2extracellular regionGO:00557636.3PIGR, KL, CNDP1, VTN, SFTPA1, SFTPD
3plasma membraneGO:00588636.3PIK3C2A, KL, KLB, CNNM1, CNNM3, CNNM4
4cytosolGO:00582934.9PIK3C2A, PDE4A, RELA, CNDP2, GCH1, BTK
5extracellular spaceGO:00561532.2KL, VTN, SFTPA1, SFTPB, SFTPC, SFTPD
6mitochondrionGO:00573930.0RDBP, GCSH, BSG, NARS2, VDAC1, VARS2
7integral to plasma membraneGO:00588724.8PIGR, PILRB, KL, BTN1A1, SELL, BPI
8mitochondrial matrixGO:00575917.0WARS2, PCCA, NARS2, RAD51, RARS2, CLPP
9external side of plasma membraneGO:00989716.8SELL, VCAM1, LDLR, MUC17, LAMP1, B2M
10cell surfaceGO:00998615.8VEGFA, LPL, VCAM1, RARA, LDLR, ATP5B
11apical plasma membraneGO:01632413.9USH2A, MUC17, MUC20, LCT, P2RY1, CFTR
12basolateral plasma membraneGO:01632313.0CNNM2, P2RY1, CFTR, ATP6V1B1, ATP7A, ATP7B
13platelet alpha granule lumenGO:03109313.0SERPINF2, SERPINA1, SERPINE1, VEGFA, VEGFC, FN1
14secretory granuleGO:03014112.9VEGFA, AVP, ATP7A, MPO, CDC42, INS

Biological processes related to pneumonia according to GeneDecks:

(show top 50)    (show all 68)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428129.4PIK3C2A, COASY, CNDP2, PCCA, GCH1, BSG
2inflammatory responseGO:00695422.2RELA, SELE, MYD88, BMP6, RAC1, PARK7
3immune responseGO:00695521.5VTN, SERPINB9, BPI, BMP6, LIF, CHUK
4signal transductionGO:00716521.5PDE4A, VEGFC, VAPA, MYD88, RARA, PAK4
5transmembrane transportGO:05508520.1CFTR, AVP, ATP6V1B1, ATP2A3, ATP4A, ATP7A
6innate immune responseGO:04508719.2RELA, SFTPD, BTK, MYD88, CLEC4A, BCL2
7cell-cell signalingGO:00726718.2LALBA, AVP, ITGB2, INS, GREM1, IL10
8proteolysisGO:00650818.1CNDP1, CNDP2, BLMH, CMA1, CLPP, PARK7
9blood coagulationGO:00759617.9SELL, SERPINC1, SERPINF2, SERPINA1, SERPINE1, BSG
10chemotaxisGO:00693517.0S100A8, FGF2, IL4, MAPK1, CCL4, CCL7
11carbohydrate metabolic processGO:00597516.8KL, KLB, NAGLU, NANP, BPGM, LCT
12transportGO:00681016.6LCN1, CFTR, ATP2A3, ATP4A, ATP2B2, ATP2B3
13response to drugGO:04249316.4PDE4A, VEGFC, LPL, RAD54L, BGLAP, PARK7
14positive regulation of cell proliferationGO:00828416.3KLB, VEGFA, VEGFC, RARA, LIF, MVD
15response to hypoxiaGO:00166615.9SFTPB, SERPINA1, VEGFA, VCAM1, BCL2, LCT
16response to lipopolysaccharideGO:03249615.0SFTPB, SFTPC, GCH1, SELE, SERPINA1, LBP
17positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312315.0RELA, VAPA, MYD88, BIRC3, LGALS9, CHUK
18cellular nitrogen compound metabolic processGO:03464114.9CNDP2, PAOX, BCAT1, BCAT2, BCKDHA, BCKDHB
19platelet activationGO:03016814.7SERPINF2, SERPINA1, SERPINE1, VEGFA, VEGFC, RAC1
20positive regulation of NF-kappaB transcription factor activityGO:05109214.6RELA, BTK, MYD88, CHUK, CD40, INS
21negative regulation of apoptotic processGO:04306614.6RELA, SERPINE1, VEGFA, BCL2, AVP, ITGAV
22nucleobase-containing small molecule metabolic processGO:05508614.5PAICS, UMPS, UCK2, XDH, ATIC, CDA
23response to glucocorticoid stimulusGO:05138414.1SFTPB, SFTPC, SERPINE1, BGLAP, BCHE, BCKDHB
24ion transportGO:00681114.1CNNM1, CNNM3, CNNM4, GLRA1, SLC9A9, SLC7A2
25anti-apoptosisGO:00691613.9RELA, SERPINB9, MYD88, BIRC3, BDNF, BCL2
26response to oxidative stressGO:00697913.9NAPRT1, LPO, MPO, MMP9, MBL2, GPX8
27tRNA aminoacylation for protein translationGO:00641813.8WARS2, NARS2, VARS, VARS2, RARS2, PARS2
28response to ethanolGO:04547113.8RBP4, BGLAP, BCL2, LCT, S100A8, AVP
29cell surface receptor signaling pathwayGO:00716613.8BSG, MYD88, BIRC3, CLEC4A, P2RY1, CD36
30Toll signaling pathwayGO:00806313.7RELA, BTK, MYD88, CHUK, LBP, JUN
31positive regulation of tumor necrosis factor productionGO:03276013.6MYD88, LBP, CD36, CD14, IL18, IL23A
32toll-like receptor 4 signaling pathwayGO:03414213.5RELA, BTK, MYD88, CHUK, JUN, CD14
33purine nucleobase metabolic processGO:00614413.4PAICS, XDH, ATIC, IMPDH1, IMPDH2, APRT
34platelet degranulationGO:00257613.3SERPINF2, SERPINA1, SERPINE1, VEGFA, VEGFC, CD36
35MyD88-dependent toll-like receptor signaling pathwayGO:00275513.2RELA, BTK, MYD88, CHUK, JUN, MAPK8
36lipopolysaccharide-mediated signaling pathwayGO:03166313.2MYD88, LBP, IRF3, IL18, IL1B, MAPK3
37cellular response to mechanical stimulusGO:07126013.2SFTPB, SFTPC, MYD88, CD40, IRF1, IL13
38cellular response to lipopolysaccharideGO:07122213.2SERPINE1, LBP, CD36, CD14, ASS1, ARG1
39agingGO:00756813.1KL, VCAM1, P2RY1, JUN, ASS1, IL15
40glycolysisGO:00609613.1BPGM, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC
41positive regulation of interleukin-12 productionGO:03273513.1CD36, CD40LG, CD40, IL23A, CCR7, CCL19
42response to organic cyclic compoundGO:01407013.0SERPINA1, MSH2, ATP12A, JUN, IL1A, IL1RN
43ATP biosynthetic processGO:00675412.8ATP2A3, ATP4A, ATP7A, ATP2B2, ATP5B, ATP2A1
44toll-like receptor signaling pathwayGO:00222412.8RELA, BTK, MYD88, CHUK, JUN, MAPK8
45glucose metabolic processGO:00600612.8INS, ENO1, ENO2, ENO3, GPI, ALDOA
46response to heatGO:00940812.7BCL2, MTHFD2, CD14, MMP9, IRF1, IL1B
47positive regulation of interleukin-8 productionGO:03275712.4SERPINE1, LBP, IL18, IL1B, MAVS, CALCA
48purine ribonucleoside monophosphate biosynthetic processGO:00916812.2PAICS, ATIC, IMPDH1, IMPDH2, GMPS, PPAT
49positive regulation of smooth muscle cell proliferationGO:04866112.1SERPINF2, MYD88, JUN, IL13, IL6, CCL5
50negative regulation of growth of symbiont in hostGO:04413012.0MYD88, LBP, CD36, IL10, MBL2, IFNG

Molecular functions related to pneumonia according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551548.2PILRB, COG2, PDE4A, RELA, REV1, CNNM3
2ATP bindingGO:00552430.6PIK3C2A, COASY, WARS2, PCCA, BTAF1, BTK
3metal ion bindingGO:04687223.0PDE4A, CNDP1, CNDP2, PCCA, BTK, NADK
4protein homodimerization activityGO:04280319.5SFTPC, GCH1, SERPINF2, VEGFA, VAPB, PARK7
5cytokine activityGO:00512516.5VEGFA, BMP6, LIF, CD40LG, FLT3LG, MIF
6receptor bindingGO:00510214.9SERPINE1, LPL, RARA, LIF, PAOX, LBP
7growth factor activityGO:00808314.8VEGFA, VEGFC, BMP6, LIF, BDNF, FGF2
8chemokine activityGO:00800914.7IL8, CCL4, CCL7, CCL27, CCL22, CCL2
9heparin bindingGO:00820114.0VTN, SELL, SERPINC1, VEGFA, LPL, LAMC2
10ATPase activityGO:01688712.7CLPX, MSH2, MSH6, ATP5B, ATP8B1, ATP5C1
11protein heterodimerization activityGO:04698212.7VEGFA, VAPA, VAPB, BMP6, RARA, BCL2
12enzyme bindingGO:01989912.5PCCA, GCSH, VAPB, RARA, RAC1, BCHE
13sodium:hydrogen antiporter activityGO:01538511.1SLC9A9, SLC9A4, SLC9A3, SLC9A8, SLC9A1, SLC9A5
14calcium-transporting ATPase activityGO:00538810.9ATP2A3, ATP2B2, ATP2A1, ATP2B3, ATP2C2, ATP2A2

Sources for Pneumonia

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS