MCID: PNM007
MIFTS: 76

Pneumonia malady

Respiratory diseases category

Summaries for Pneumonia

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Sources:
9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Pneumonia is an infection in one or both of the lungs. many germs, such as bacteria, viruses, and fungi, can cause pneumonia. you can also get pneumonia by inhaling a liquid or chemical. people most at risk are older than 65 or younger than 2 years of age, or already have health problems. symptoms of pneumonia vary from mild to severe. see your doctor promptly if you have a high fever have shaking chills have a cough with phlegm that doesn't improve or gets worse develop shortness of breath with normal daily activities have chest pain when you breathe or cough feel suddenly worse after a cold or the flu your doctor will use your medical history, a physical exam, and lab tests to diagnose pneumonia. treatment depends on what kind you have. if bacteria are the cause, antibiotics should help. if you have viral pneumonia, your doctor may prescribe an antiviral medicine to treat it. preventing pneumonia is always better than treating it. vaccines are available to prevent pneumococcal pneumonia and the flu. other preventive measures include washing your hands frequently and not smoking. nih: national heart, lung, and blood institute

MalaCards: Pneumonia, also known as acute pneumonia, is related to bronchiolitis obliterans and bronchiolitis. An important gene associated with Pneumonia is CRP (C-reactive protein, pentraxin-related), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drugs acetylcysteine and oxygen and the compounds sivelestat and salmeterol have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and liver, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Disease Ontology:9 A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). it results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. it is accompanied by fever, chills, cough, and difficulty in breathing.

CDC:4 Pneumocystis pneumonia (PCP) is a serious illness caused by the fungus Pneumocystis jirovecii. PCP is one of the most frequent and severe opportunistic infections in people with weakened immune systems, particularly people with HIV/AIDS. Although people with HIV/AIDS are less likely to get PCP today than in recent years, PCP is still a significant public health problem.

Wikipedia:66 Pneumonia is an inflammatory condition of the lung affecting primarily the microscopic air sacs known as... more...

Aliases & Classifications for Pneumonia

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9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Related Diseases for Pneumonia

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18GeneCards, 19GeneDecks
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Diseases in the Pneumonia family:

Viral Pneumonia

Diseases related to Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 871)
idRelated DiseaseScoreTop Affiliating Genes
1bronchiolitis obliterans31.6IL8, CXCR3
2bronchiolitis31.6IL13, IL8, IL5, CCL11, RNASE3
3eosinophilic pneumonia31.5IL13, IL5, CCL11, CCL22, CCL17, RNASE3
4chronic eosinophilic pneumonia31.3IL5, CCL11, RNASE3
5desquamative interstitial pneumonia31.3TNC
6influenza31.1IFNG, CCL11, CXCR3, NEU1, LACTB, SFTPD
7bacteremia31.0CRP, LACTB
8arthritis31.0IL6, IL8
9meningitis30.9CRP, IL6, IL8, LACTB
10sepsis30.9NEU1, LACTB
11respiratory failure30.9SFTPD, PIK3C2A
12otitis media30.8CCL11, RNASE3, LACTB
13asthma30.8IL13, CCL11
14endophthalmitis30.8LACTB
15tuberculosis30.8CRP, IFNG, CCR4, CXCR3, LACTB, SFTPD
16interstitial lung disease30.7CCL2, SFTPD
17pulmonary fibrosis30.7IL13, IL8, CCL22, CCR4, CCL2, CCL17
18dysphagia30.7PIK3C2A
19adult respiratory distress syndrome30.6IL8, ELANE
20leukemia30.6IL6, IFNG, CCL11, CXCR3, RNASE3, LACTB
21idiopathic pulmonary fibrosis30.6IL13, IL8, IFNG, CCL22, CCR4, CCL2
22rhinitis30.6IL13, IL8, IL5, CCL11, RNASE3
23conjunctivitis30.6RNASE3
24vascular disease30.6CRP, CCL2, ELANE, TNC
25rheumatoid arthritis30.6CRP, IL13, IL6, IL8, IFNG, CCL11
26lung cancer30.6CCL22, CCR4, CXCR3, TNC, SFTPD
27aspergillosis30.6IFNG, ELANE, SFTPD
28pulmonary alveolar proteinosis30.5CCL2, SFTPC, SFTPD
29mediastinitis30.5CRP
30encephalomyelitis30.5IFNG, CCL2, CXCR3
31septic shock30.5CRP, IL6, IL8, ELANE, LACTB, PIK3C2A
32bronchitis30.5IL8, IL5, CCL11, ELANE, RNASE3, LACTB
33atherosclerosis30.4CRP, IL6, IL8, CCL11, CCL2, ELANE
34systemic lupus erythematosus30.4CRP, IL6, IFNG, CCR4, CCL2, CXCR3
35esophagitis30.4IL13, IL5, CCL11
36sarcoidosis30.4IL13, IFNG, CCL11, CCR4, CCL2, CXCR3
37bronchiectasis30.4IL8, ELANE, RNASE3
38septic arthritis30.4CRP
39coronary artery disease30.3CRP, IL6, PIK3C2A
40uveitis30.3IFNG, CCL11, CCR4, CCL2, CXCR3
41vasculitis30.3CRP, CCL2, ELANE
42adult-onset still's disease30.3CRP, IL6
43pharyngitis30.3LACTB
44churg-strauss syndrome30.3IL5, RNASE3
45sinusitis30.3IL5, CCL11, RNASE3, LACTB
46allergic bronchopulmonary aspergillosis30.3IL5, SFTPD
47peritonitis30.3CRP, IL6, CCL2, LACTB
48aortic aneurysm30.3CRP
49exanthem30.2CRP
50diabetes mellitus30.2CRP, IL6, CCL2, NEU1, PIK3C2A

Graphical network of the top 20 diseases related to Pneumonia:



Diseases related to pneumonia

Symptoms for Pneumonia

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Drugs & Therapeutics for Pneumonia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Pneumonia

Drug clinical trials:

Search ClinicalTrials for Pneumonia

Search NIH Clinical Center for Pneumonia

Search CenterWatch for Pneumonia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Pneumonia

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Anatomical Context for Pneumonia

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34MalaCards
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MalaCards organs/tissues related to Pneumonia:

34
Lung, Testes, Liver, Heart, Endothelial, T cells, Bone, Bone marrow, Colon, Breast, Brain, Monocytes, Myeloid, Smooth muscle, Skin, Kidney, B cells, Tonsil, Prostate, Nk cells, Pituitary, Thymus, Eye, Pancreatic islet, Tongue, Spleen, Uterus, Lymph node, Bronchial epithelium, Whole blood, Thyroid

Animal Models for Pneumonia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pneumonia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8SFTPC, CXCR3, ELANE, CCL2, IFNG, IL5
2MP:00053858.7NEU1, CXCR3, CCL2, IFNG, IL6, CRP
3MP:00053888.0SFTPD, SFTPC, NEU1, CXCR3, CCR4, CCL11
4MP:00053787.8PIK3C2A, SFTPD, SFTPC, NEU1, CCL2, IFNG
5MP:00107687.6PIK3C2A, SFTPD, SFTPC, NEU1, CXCR3, ELANE
6MP:00053767.3CXCR3, NEU1, TNC, SFTPD, PIK3C2A, ELANE
7MP:00053976.7CCL17, ELANE, CXCR3, NEU1, SFTPD, PIK3C2A
8MP:00053876.4CRP, PIK3C2A, SFTPD, SFTPC, NEU1, CXCR3

Publications for Pneumonia

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53PubMed
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Articles related to Pneumonia:

(show top 50)    (show all 5066)
idTitleAuthorsYear
1
Mutant prevention concentrations of colistin for Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae clinical isolates. (23997018)
2014
2
Strategies to prevent ventilation-associated pneumonia: the effect of cuff pressure monitoring techniques and tracheal tube type on aspiration of subglottic secretions: An in-vitro study. (24270899)
2013
3
Genome Sequence of Klebsiella pneumoniae Strain ATCC 25955, an Oxygen-Insensitive Producer of 1,3-Propanediol. (23929480)
2013
4
Tracheal bronchus associated with recurrent pneumonia. (24082287)
2013
5
Community-acquired pneumonia versus healthcare-associated pneumonia. The returning pendulum. (24127797)
2013
6
Soluble B7-H3 elevations in hospitalized children with Mycoplasma pneumoniae pneumonia. (24139879)
2013
7
Inhibition of Klebsiella pneumoniae Growth and Capsular Polysaccharide Biosynthesis by Fructus mume. (24062785)
2013
8
Daptomycin-induced acute eosinophilic pneumonia: analysis of the current data and illustrative case reports. (23826793)
2013
9
Detection of clonal KPC-2-producing Klebsiella pneumoniae ST258 in Korea during nationwide surveillance in 2011. (23741020)
2013
10
Chronic Eosinophilic Pneumonia in a Breast Cancer Patient Post Radiation Therapy: A Case Report. (24026185)
2013
11
Risk factors for treatment failure of polymyxin B monotherapy for carbapenem-resistant Klebsiella pneumoniae infections. (23959321)
2013
12
Cough Sound Analysis - A new tool for diagnosing Pneumonia. (24110911)
2013
13
Cryptogenic organizing pneumonia during adjuvant chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX) for colon cancer. (22842502)
2013
14
Single-Day Trimethoprim/Sulfamethoxazole Prophylaxis for Pneumocystis Pneumonia in Children with Cancer. (24252793)
2013
15
A case of adult-onset Still's disease complicated by hemophagocytic syndrome and interstitial pneumonia with pneumomediastinum/recurrent pneumothorax. (22898226)
2012
16
Postoperative meningitis and epidural abscess due to extended-spectrum I^-lactamase-producing Klebsiella pneumoniae: a case report and a review of the literature. (22989843)
2012
17
Mycoplasma pneumoniae infection associated with urticarial vasculitis mimicking adult-onset Still's disease. (21918897)
2012
18
Abdominal infectious aortitis caused by Streptococcus pneumoniae: a case report and literature review. (20926247)
2011
19
Roles of capsule and lipopolysaccharide O antigen in interactions of human monocyte-derived dendritic cells and Klebsiella pneumoniae. (19841082)
2010
20
Organizing pneumonia in a patient with newly diagnosed acquired immunodeficiency syndrome. (21048369)
2010
21
Pneumocystis jirovecii pneumonia in a baby with hyper-IgE syndrome. (19308447)
2010
22
Mycoplasma pneumoniae--associated transverse myelitis and rhabdomyolysis. (19135630)
2009
23
Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia. (19114892)
2009
24
Review: pneumococcal vaccination does not prevent pneumonia, bacteraemia, bronchitis, or mortality. (19553411)
2009
25
Understanding nonspecific interstitial pneumonia: the need for a diagnostic gold standard. (19158329)
2009
26
Homology modeling of Mycoplasma pneumoniae enolase and its molecular interaction with human plasminogen. (19052661)
2008
27
Effect of regular intravenous immunoglobulin therapy on prevention of pneumonia in patients with common variable immunodeficiency. (16604243)
2006
28
Definitive techniques for intractable aspiration pneumonia. (16707166)
2006
29
Relationship between peripheral arterial occlusive disease (PAOD) and chronic Chlamydophila (Chlamydia) pneumoniae infection. A meta-analysis. (15968402)
2005
30
Squalene aspiration pneumonia in children: radiographic and CT findings as the first clue to diagnosis. (15806404)
2005
31
Fibroblastic foci in usual interstitial pneumonia. (14982825)
2004
32
The incidence and clinical characteristics of bronchiolitis obliterans organizing pneumonia syndrome after radiation therapy for breast cancer. (15554078)
2004
33
Efficacy of intravenous immunoglobulin on the prevention of pneumonia in patients with agammaglobulinemia. (14987729)
2004
34
Predicting survival of lung transplantation candidates with idiopathic interstitial pneumonia: does PaO(2) predict survival? (12226013)
2002
35
Levels of interleukin-2, interferon-gamma, and interleukin-4 in bronchoalveolar lavage fluid from patients with Mycoplasma pneumonia: implication of tendency toward increased immunoglobulin E production. (11230620)
2001
36
Procalcitonin in pyelonephritis and acute community-acquired pneumonia in adults]. (11484399)
2001
37
Surfactant protein D and KL-6 as serologic indicators of Pneumocystis carinii pneumonia in a child with acute lymphoblastic leukemia. (11321887)
2001
38
Bilateral symmetrical upper-lobe opacities: an unusual presentation of bronchiolitis obliterans organizing pneumonia. (10988217)
2000
39
Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression: a potential link to accelerated arteriosclerosis. (10500035)
1999
40
Usual interstitial pneumonia: relationship between disease activity and the progression of honeycombing at thin-section computed tomography. (9671423)
1998
41
Exogenous lipoid pneumonia complicated by Mycobacterium fortuitum and Aspergillus fumigatus infections. (8834351)
1996
42
Treatment of aspiration pneumonia with low-dose methylprednisolone and antibiotics]. (7699968)
1995
43
TNF and pneumonia. (7632260)
1994
44
Effect of ventilation with positive end-expiratory pressure on the development of lung damage in experimental acid aspiration pneumonia in the rabbit. (1613190)
1992
45
Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome. (1672788)
1991
46
Serological evidence of viral or Mycoplasma pneumoniae infection in acute maxillary sinusitis. (2498094)
1989
47
Desquamative interstitial pneumonia. Computed tomographic findings before and after treatment with corticosteroids. (3335161)
1988
48
Aspiration pneumonia and coma--an unusual presentation of dystrophic myotonia. (3779503)
1986
49
Desquamative interstitial pneumonia associated with granulomatous lymphadenopathy. (923315)
1977
50
Desquamative interstitial pneumonia. A form of muscular cirrhosis of the lung fibrosing alveolitis. (5555709)
1971

Variations for Pneumonia

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Expression for genes affiliated with Pneumonia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pneumonia

Search GEO for disease gene expression data for Pneumonia.

Pathways for genes affiliated with Pneumonia

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Sources:
51PathCards, 61Thomson Reuters, 55R&D Systems, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 54QIAGEN, 13EMD Millipore, 62Tocris Bioscience
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Pathways related to Pneumonia according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CCL11, CCL2
29.8IL13, IL6, IL5
39.8IL6, IL8, CCL11
49.8CCL2, IL8, IL6
5
Show member pathways
9.8CCL2, IL8, IL6
69.8IL13, IL5, IFNG
7
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.8IFNG, IL5, IL8
89.8IL5, CCL11, CCL17
9
Show member pathways
Immune response MIF in innate immunity response61
9.8IL6, IL8, IFNG
109.8IL6, IL8, IFNG
119.8IL6, IL8, IFNG
129.8IFNG, IL8, IL6
139.8IFNG, IL8, IL6
14
Show member pathways
9.8IFNG, IL8, IL6
15
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.7IL6, IFNG, CCL2
169.6CCL11, IL5, IL8, IL6
17
Show member pathways
9.6IL13, IL5, PIK3C2A
18
Show member pathways
Type III interferon signaling39
9.6IFNG, IL5, IL6, IL13
19
Show member pathways
9.6IL13, IL6, IL5, IFNG
209.6IL13, IL6, IL5, IFNG
21
Show member pathways
thioredoxin pathway39
9.6CCL2, IFNG, IL6, CRP
22
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.5CCL2, IFNG, IL8, IL6
239.5CCL2, IFNG, IL8, IL6
249.5CCL2, IFNG, IL8, IL6
259.5CCL2, IFNG, IL8, IL6
269.4IFNG, IL5, IL8, IL6, IL13
279.4IFNG, IL5, IL8, IL6, IL13
28
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.4SFTPD, CCL11, IFNG, IL8, IL6
29
Show member pathways
9.4CCL2, IFNG, IL8, IL6, IL13
30
Show member pathways
9.1RNASE3, CCL11, IFNG, IL5, IL6, IL13
31
Show member pathways
8.5CXCR3, CCL17, CCL2, CCR4, CCL22, CCL11
32
Show member pathways
8.5CXCR3, CCL17, CCL2, CCR4, CCL22, CCL11
33
Show member pathways
8.5CXCR3, CCL17, CCL2, CCR4, CCL22, CCL11
34
Show member pathways
8.5IL8, CXCR3, CCL17, CCL2, CCR4, CCL22
35
Show member pathways
8.3CCL17, CCL2, CCL22, CCL11, IFNG, IL5
36
Show member pathways
8.2TNC, CXCR3, CCL17, CCL2, CCR4, CCL22
37
Show member pathways
7.9IL6, IL8, IL5, CCL11, CCL22, CCR4
38
Show member pathways
7.9CXCR3, IL13, IL6, IL8, IL5, CCL11
39
Show member pathways
7.6TNC, CXCR3, CCL17, CCL2, CCR4, CCL22
40
Show member pathways
7.6CXCR3, CCL17, CCL2, CCR4, CCL22, CCL11

Compounds for genes affiliated with Pneumonia

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Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 12DrugBank, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Pneumonia according to GeneCards/GeneDecks:

(show top 50)    (show all 236)
idCompoundScoreTop Affiliating Genes
1sivelestat469.8SFTPD, IL6, IL8, ELANE
2salmeterol46 52 30 1212.8IL8, IL13, CCL11, IL5, RNASE3
3montelukast46 52 30 1212.7IL8, RNASE3, CCL11, IL5, IL13
4mcp 1469.7IL8, IL6, CXCR3, CCL2, IL5
5cetirizine46 30 25 1212.7CCL11, IL5, IL8, RNASE3
6roxithromycin46 30 1211.7IL5, IL8, CCL17, CCL11
7salbutamol46 52 30 25 1213.7IL5, CCL11, IL8, IL13, RNASE3
8groalpha469.6CXCR3, CCL2, CCL11, IL8, IL13, IL6
9gabexate mesilate469.5ELANE, IL8, IL6, CRP
10il-12469.5CCL2, IL13, IL6, IL5, IL8, IFNG
11etanercept46 52 1211.5CRP, IL6, IL8, IFNG, CXCR3
12anaphylatoxin469.5IL8, RNASE3, ELANE, CCL2, IL6
13poly(i-c)469.5IL8, IL5, CCL11, IL6, IFNG
14budesonide46 52 1211.5IL13, IL8, IL5, IFNG, CCL11, RNASE3
15rolipram46 62 3011.4IL5, IFNG, CCL11, ELANE, IL8, IL13
16methacholine46 52 1211.4CRP, IL13, CCL22, IL8, CCL11, IL5
17fluticasone propionate46 52 62 1212.3RNASE3, ELANE, CCL11, IL13, IL8, IL5
18gm-csf46 3010.2IL13, IL6, IL8, IL5, IFNG, CCL2
19larc469.2CCL2, CCL17, CCR4, CXCR3, CCL22
20hydrocortisone46 3 62 1212.1IL13, CXCR3, IL6, IL8, IL5, IFNG
21herbimycin a46 6210.1IL5, IL8, IFNG, CCL11, CCL2, IL6
22allergens469.1CXCR3, SFTPD, RNASE3, CCL17, IL13, CCL11
23fmlp469.1ELANE, CXCR3, CCL11, IL5, IL8, IL13
24il 10469.1CCL17, CXCR3, CCL2, IFNG, IL13, IL6
25tacrolimus46 52 1211.0CCL22, CXCR3, CCL11, IFNG, IL5, IL13
26actinomycin d468.9TNC, SFTPC, CCL11, IL13, IL6, IL8
27ccl446 309.9CCR4, IL13, CCL11, CXCR3, CCL17, CCL2
28hyaluronic acid46 259.8ELANE, IL8, TNC, RNASE3, NEU1, CCL11
29sb 20358046 629.8CRP, IL13, IL8, IL5, IFNG, CCL11
30leukotriene b446 62 2510.8RNASE3, ELANE, CCL2, CCL22, CCL11, IL5
31simvastatin46 52 62 30 25 1213.7IFNG, CCL2, PIK3C2A, CCR4, IL8, IL6
32lactate468.6IL8, IL13, PIK3C2A, IL6, CRP, RNASE3
33cycloheximide468.5TNC, NEU1, CCL2, IFNG, IL5, IL8
34nitric oxide46 25 1210.5SFTPD, RNASE3, CXCR3, CCL17, IL13, IL6
35endotoxin468.4CRP, IFNG, CCL11, CCL2, ELANE, CXCR3
36ly294002468.4IL8, PIK3C2A, CXCR3, CCL11, IL5, CRP
37tarc468.3IL5, IL13, IL8, IFNG, CCL11, CCL22
38pge2468.3CXCR3, ELANE, CCL2, CCL22, CCL11, IFNG
39prednisolone46 30 1210.2SFTPD, RNASE3, CCR4, CCL11, IFNG, IL5
40ccl346 309.2CCL11, CCL22, CCR4, CCL2, CCL17, CXCR3
41heparin46 30 25 1211.1IL13, PIK3C2A, TNC, RNASE3, NEU1, CXCR3
42fibrinogen468.1PIK3C2A, SFTPC, TNC, RNASE3, ELANE, CCL17
43histamine46 30 2510.0SFTPD, IL5, IFNG, CCL11, CCL22, CCL2
44cyclosporin a46 30 629.9PIK3C2A, RNASE3, ELANE, CCL17, CCL22, CCL11
45retinoic acid46 258.8IL13, IL6, RNASE3, TNC, SFTPC, IL5
46rantes467.8RNASE3, IL8, CXCR3, IL13, CCL17, CCL2
47vegf467.7CRP, IL13, IL6, PIK3C2A, SFTPC, TNC
48dexamethasone46 52 30 1210.6CCL2, SFTPC, TNC, RNASE3, IL13, IL6
49lipid467.5SFTPD, SFTPC, TNC, CCL2, CCR4, CCL11
50calcium46 52 25 1210.0CCL22, PIK3C2A, SFTPD, SFTPC, RNASE3, CXCR3

GO Terms for genes affiliated with Pneumonia

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Sources:
17Gene Ontology
See all sources

Cellular components related to Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1IL13, IL6, IFNG, CCR4, CXCR3
2extracellular spaceGO:0056157.2IL13, IL6, IL8, IL5, IFNG, CCL11
3extracellular regionGO:0055767.0CRP, SFTPD, IL13, IL6, IL8, IL5

Biological processes related to Pneumonia according to GeneCards/GeneDecks:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:01088810.4CRP, IL6
2regulation of vascular endothelial growth factor productionGO:01057410.4IL6, CCL2
3positive regulation of immunoglobulin secretionGO:05102410.3IL6, IL5
4neutrophil apoptotic processGO:00178110.3IFNG, IL6
5negative regulation of chemokine biosynthetic processGO:04507910.3ELANE, IL6
6macrophage chemotaxisGO:04824610.3SFTPD, CCL2
7positive regulation of JAK-STAT cascadeGO:04642710.2IL5, IL6
8neutrophil chemotaxisGO:03059310.2IL8, IFNG, CCL2
9response to glucocorticoidGO:05138410.1IL6, CCL2, SFTPC
10cellular response to lipopolysaccharideGO:07122210.1CCL2, IFNG, IL8
11response to mechanical stimulusGO:00961210.1TNC, CCL2, IL6
12positive regulation of smooth muscle cell proliferationGO:04866110.1IL13, IL6, ELANE
13agingGO:00756810.1CCL2, IL6, CRP
14humoral immune responseGO:00695910.1IL6, IFNG, CCL2
15endoplasmic reticulum unfolded protein responseGO:03096810.1IL8, IFNG, CCL2
16response to ethanolGO:04547110.0TNC, CCL2, IL13, CRP
17regulation of cell shapeGO:00836010.0IL6, CCL11, CCL2
18defense response to protozoanGO:04283210.0IL6, IFNG
19cellular calcium ion homeostasisGO:00687410.0ELANE, CCL2, CCL11
20monocyte chemotaxisGO:00254810.0IL6, CCL2
21negative regulation of growth of symbiont in hostGO:04413010.0IFNG, ELANE
22cellular component movementGO:00692810.0IL13, IL8, IFNG, CXCR3
23cellular response to fibroblast growth factor stimulusGO:04434410.0CCL2, IL8
24response to antibioticGO:0466779.9CCL2, CCR4, IL6
25response to lipopolysaccharideGO:0324969.9IL13, IL6, ELANE, SFTPC
26defense response to bacteriumGO:0427429.9SFTPD, RNASE3, ELANE, IFNG
27cytokine-mediated signaling pathwayGO:0192219.8CCL2, IFNG, IL5, IL6
28response to virusGO:0096159.8IFNG, CCL11, CCL22
29response to bacteriumGO:0096179.8CCR4, CCL2
30G-protein coupled receptor signaling pathwayGO:0071869.8CXCR3, CCL17, CCL2, IL8
31cell adhesionGO:0071559.2CCL11, CCL2, CXCR3, TNC
32immune responseGO:0069559.0CCL17, CCR4, CCL22, CCL11, IL5, IL8
33chemotaxisGO:0069358.9CXCR3, CCL17, CCL2, CCR4, CCL22, CCL11
34inflammatory responseGO:0069548.1CRP, CXCR3, CCL17, CCL2, CCR4, CCL22

Molecular functions related to Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.8CCR4, CXCR3
2cytokine activityGO:0051259.3IFNG, IL5, IL6, IL13
3chemokine activityGO:0080099.1IL8, CCL11, CCL22, CCL2, CCL17

Products for genes affiliated with Pneumonia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pneumonia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet