Aliases & Classifications for Pneumonic Plague

Aliases & Descriptions for Pneumonic Plague:

Name: Pneumonic Plague 12 14 69
Secondary Pneumonic Plague 12 69
Primary Pneumonic Plague 12 69
Plague 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10398
ICD10 33 A20.2
ICD9CM 35 020.3 020.4 020.5
MeSH 42 D010930

Summaries for Pneumonic Plague

Disease Ontology : 12 A plague that results_in infection located in lung, which results from direct inhalation of the bacillus and has symptom fever, has symptom chills, has symptom cough and has symptom difficulty breathing.

MalaCards based summary : Pneumonic Plague, also known as secondary pneumonic plague, is related to plague and bubonic plague, and has symptoms including fever, chills and cough. An important gene associated with Pneumonic Plague is PLG (Plasminogen), and among its related pathways/superpathways are Spinal Cord Injury and Cell adhesion_ECM remodeling. The drugs Streptomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and testes, and related phenotype is mortality/aging.

Wikipedia : 71 Pneumonic plague is a severe lung infection caused by the bacterium Yersinia pestis. Symptoms include... more...

Related Diseases for Pneumonic Plague

Diseases related to Pneumonic Plague via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 plague 11.8
2 bubonic plague 9.9
3 hepatitis 9.8
4 leptospirosis 9.8
5 tuberculosis 9.8
6 acute pericementitis 8.8 AGPS GAP43 HOXA1 IGFBP7 LPP PLG

Graphical network of the top 20 diseases related to Pneumonic Plague:



Diseases related to Pneumonic Plague

Symptoms & Phenotypes for Pneumonic Plague

Symptoms:

12
  • fever
  • chills
  • cough
  • difficulty breathing

UMLS symptoms related to Pneumonic Plague:


fever, pruritus

MGI Mouse Phenotypes related to Pneumonic Plague:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.17 AGPS GAP43 HOXA1 LPP PLG RIMS1

Drugs & Therapeutics for Pneumonic Plague

Drugs for Pneumonic Plague (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Streptomycin Approved, Vet_approved Phase 2, Phase 3 57-92-1 19649
2 Anti-Bacterial Agents Phase 2, Phase 3
3 Anti-Infective Agents Phase 2, Phase 3
4 Gentamicins Phase 2, Phase 3
5
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
6
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
7 Cytochrome P-450 CYP1A2 Inhibitors Phase 2
8 Cytochrome P-450 Enzyme Inhibitors Phase 2
9 Topoisomerase Inhibitors Phase 2
10 Antimalarials Phase 2
11 Antiparasitic Agents Phase 2
12 Antiprotozoal Agents Phase 2
13 Vaccines Phase 2,Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Treatment and Diagnosis of Plague Completed NCT00128466 Phase 2, Phase 3
2 A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2
3 Immunogenicity and Safety of Subunit Plague Vaccine Completed NCT02596308 Phase 2
4 Safety, Tolerability & Immunogenicity of the Recombinant Plague Vaccine rF1V Completed NCT00097396 Phase 1

Search NIH Clinical Center for Pneumonic Plague

Cochrane evidence based reviews: plague

Genetic Tests for Pneumonic Plague

Anatomical Context for Pneumonic Plague

MalaCards organs/tissues related to Pneumonic Plague:

39
Lung, Neutrophil, Testes, T Cells, Spleen

The Foundational Model of Anatomy Ontology organs/tissues related to Pneumonic Plague:

18
Lung

Publications for Pneumonic Plague

Articles related to Pneumonic Plague:

(show top 50) (show all 159)
id Title Authors Year
1
New Insights into Autoinducer-2 Signaling as a Virulence Regulator in a Mouse Model of Pneumonic Plague. ( 27981238 )
2016
2
Plazomicin is effective in a non-human primate pneumonic plague model. ( 27614915 )
2016
3
Correction: Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A Transcriptomic Analysis. ( 27078634 )
2016
4
Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A Transcriptomic Analysis. ( 27003632 )
2016
5
Plague in China 2014-All sporadic case report of pneumonic plague. ( 26895880 )
2016
6
Host transcriptomic responses to pneumonic plague reveal that Yersinia pestis inhibits both the initial adaptive and innate immune responses in mice. ( 27876297 )
2016
7
Intranasal delivery of a protein subunit vaccine using a Tobacco Mosaic Virus platform protects against pneumonic plague. ( 27745954 )
2016
8
Pneumonic Plague: The Darker Side of Yersinia pestis. ( 26698952 )
2016
9
Circumventing Y. pestis Virulence by Early Recruitment of Neutrophils to the Lungs during Pneumonic Plague. ( 25974210 )
2015
10
Outbreak of Human Pneumonic Plague with Dog-to-Human and Possible Human-to-Human Transmission--Colorado, June-July 2014. ( 25928467 )
2015
11
Spatially Distinct Neutrophil Responses within the Inflammatory Lesions of Pneumonic Plague. ( 26463167 )
2015
12
Combinational Deletion of Three Membrane Protein-Encoding Genes Highly Attenuates Yersinia pestis while Retaining Immunogenicity in a Mouse Model of Pneumonic Plague. ( 25605764 )
2015
13
Primary case of human pneumonic plague occurring in a Himalayan marmot natural focus area Gansu Province, China. ( 25555623 )
2015
14
Impact of the Pla Protease Substrate I+2-Antiplasmin on the Progression of Primary Pneumonic Plague. ( 26438794 )
2015
15
Correction: Yersinia pestis Activates Both IL-1I^ and IL-1 Receptor Antagonist to Modulate Lung Inflammation during Pneumonic Plague. ( 25970482 )
2015
16
Controlling Ebola: what we can learn from China's 1911 battle against the pneumonic plague in Manchuria. ( 25722280 )
2015
17
Pneumonic plague outbreak, Northern Madagascar, 2011. ( 25530466 )
2015
18
Characterization of a Cynomolgus Macaque Model of Pneumonic Plague for Evaluation of Vaccine Efficacy. ( 26224691 )
2015
19
Intramuscular immunization of mice with a live-attenuated triple mutant of Yersinia pestis CO92 induces robust humoral and cell-mediated immunity to completely protect animals against pneumonic plague. ( 26446423 )
2015
20
Yersinia pestis activates both IL-1I^ and IL-1 receptor antagonist to modulate lung inflammation during pneumonic plague. ( 25781467 )
2015
21
Evaluation of imipenem for prophylaxis and therapy of Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague. ( 24687492 )
2014
22
Remote monitoring of the progression of primary pneumonic plague in Brown Norway rats in high-capacity, high-containment housing. ( 24719212 )
2014
23
Efficacy of primate humoral passive transfer in a murine model of pneumonic plague is mouse strain-dependent. ( 25097863 )
2014
24
IL-17A Produced by Neutrophils Protects against Pneumonic Plague through Orchestrating IFN-I^-Activated Macrophage Programming. ( 24337746 )
2014
25
Deletion of Braun lipoprotein and plasminogen-activating protease-encoding genes attenuates Yersinia pestis in mouse models of bubonic and pneumonic plague. ( 24686064 )
2014
26
LcrV delivered via type III secretion system of live attenuated Yersinia pseudotuberculosis enhances immunogenicity against pneumonic plague. ( 25114109 )
2014
27
Discovery of a leptospirosis cluster amidst a pneumonic plague outbreak in a miners' camp in the Democratic Republic of the Congo. ( 24514425 )
2014
28
A cluster of primary pneumonic plague transmitted in a truck cab in a new enzootic focus in China. ( 23509116 )
2013
29
A non-invasive in vivo imaging system to study dissemination of bioluminescent Yersinia pestis CO92 in a mouse model of pneumonic plague. ( 23063826 )
2013
30
Early apoptosis of macrophages modulated by injection of Yersinia pestis YopK promotes progression of primary pneumonic plague. ( 23633954 )
2013
31
Early host cell targets of Yersinia pestis during primary pneumonic plague. ( 24098126 )
2013
32
Transmission dynamics of primary pneumonic plague in the USA. ( 21733272 )
2012
33
An encapsulated Yersinia pseudotuberculosis is a highly efficient vaccine against pneumonic plague. ( 22348169 )
2012
34
Can sputum collection practices for tuberculosis improve laboratory diagnosis of pneumonic plague in developing countries? ( 22039916 )
2012
35
Phagocytes and humoral immunity to pneumonic plague. ( 22782760 )
2012
36
Establishment of a Swiss Webster mouse model of pneumonic plague to meet essential data elements under the animal rule. ( 22336286 )
2012
37
Intranasal administration of an inactivated Yersinia pestis vaccine with interleukin-12 generates protective immunity against pneumonic plague. ( 21880856 )
2011
38
Lessons learned about pneumonic plague diagnosis from two outbreaks, Democratic Republic of the Congo. ( 21529384 )
2011
39
An individual-based simulation of pneumonic plague transmission following an outbreak and the significance of intervention compliance. ( 21624780 )
2011
40
Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation. ( 20722770 )
2011
41
Levofloxacin cures experimental pneumonic plague in African green monkeys. ( 21347450 )
2011
42
Characterization of an F1 deletion mutant of Yersinia pestis CO92, pathogenic role of F1 antigen in bubonic and pneumonic plague, and evaluation of sensitivity and specificity of F1 antigen capture-based dipsticks. ( 21367990 )
2011
43
A dog-associated primary pneumonic plague in Qinghai Province, China. ( 21288842 )
2011
44
A comprehensive study on the role of the Yersinia pestis virulence markers in an animal model of pneumonic plague. ( 21468758 )
2011
45
Cynomolgus macaque model for pneumonic plague. ( 21040776 )
2011
46
Serum cytokine responses in primary pneumonic plague patients. ( 21106776 )
2011
47
Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines. ( 21763383 )
2011
48
Chemokine receptor CXCR2 mediates bacterial clearance rather than neutrophil recruitment in a murine model of pneumonic plague. ( 21356370 )
2011
49
Yersinia pestis YopE contains a dominant CD8 T cell epitope that confers protection in a mouse model of pneumonic plague. ( 21653834 )
2011
50
Recombinant (F1+V) vaccine protects cynomolgus macaques against pneumonic plague. ( 21570437 )
2011

Variations for Pneumonic Plague

Expression for Pneumonic Plague

Search GEO for disease gene expression data for Pneumonic Plague.

Pathways for Pneumonic Plague

Pathways related to Pneumonic Plague according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.23 GAP43 VCAN
2 10.74 PLG VCAN
3 10.21 PLG VCAN

GO Terms for Pneumonic Plague

Biological processes related to Pneumonic Plague according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 8.8 IGFBP7 PLG VCAN

Molecular functions related to Pneumonic Plague according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.23 AGPS GAP43 HOXA1 IGFBP7 LPP PLG

Sources for Pneumonic Plague

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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