MCID: PNM005
MIFTS: 37

Pneumonic Plague malady

Infectious diseases category

Summaries for Pneumonic Plague

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A plague that results in infection located in lung, which results from direct inhalation of the bacillus and has symptom fever, has symptom chills, has symptom cough and has symptom difficulty breathing.

MalaCards: Pneumonic Plague, also known as secondary pneumonic plague, is related to plague and bubonic plague, and has symptoms including fever, chills and cough. An important gene associated with Pneumonic Plague is CHST3 (carbohydrate (chondroitin 6) sulfotransferase 3), and among its related pathways is Toll-Like receptor Signaling Pathways. The compounds n-acetylglucosamine and mannose have been mentioned in the context of this disorder. Affiliated tissues include lung, lung and testes.

Wikipedia:63 Pneumonic plague, is a severe type of lung infection, is one of three main forms of plague, all of which... more...

Aliases & Classifications for Pneumonic Plague

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

pneumonic plague 8 10 60
secondary pneumonic plague 8 60
primary pneumonic plague 8 60
pneumonic plague, unspecified 8


External Ids:

Disease Ontology8 DOID:10398
ICD9CM27 020.3
ICD1025 A20.2

Related Diseases for Pneumonic Plague

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pneumonic Plague via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1plague11.2
2bubonic plague10.8
3septicemic plague10.1
4hepatitis10.1
5tuberculosis10.1

Graphical network of diseases related to Pneumonic Plague:



Diseases related to pneumonic plague

Clinical Features for Pneumonic Plague

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8Disease Ontology
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Symptoms:

8
  • fever
  • chills
  • cough
  • difficulty breathing

Drugs & Therapeutics for Pneumonic Plague

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Pneumonic Plague

Search NIH Clinical Center for Pneumonic Plague

Search CenterWatch for Pneumonic Plague

Genetic Tests for Pneumonic Plague

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Anatomical Context for Pneumonic Plague

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Pneumonic Plague:

32
Lung, Testes, T cells, Spleen

FMA organs/tissues related to Pneumonic Plague:

14
Lung

Animal Models for Pneumonic Plague or affiliated genes

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Publications for Pneumonic Plague

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50PubMed
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Articles related to Pneumonic Plague:

(show top 50)    (show all 139)
idTitleAuthorsYear
1
Characterization of systemic and pneumonic murine models of plague infection using a conditionally virulent strain. (23195858)
2013
2
Can sputum collection practices for tuberculosis improve laboratory diagnosis of pneumonic plague in developing countries? (22039916)
2012
3
Transmission dynamics of primary pneumonic plague in the USA. (21733272)
2012
4
Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines. (21763383)
2011
5
Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation. (20722770)
2011
6
A dog-associated primary pneumonic plague in Qinghai Province, China. (21288842)
2011
7
Intranasal administration of an inactivated Yersinia pestis vaccine with interleukin-12 generates protective immunity against pneumonic plague. (21880856)
2011
8
An individual-based simulation of pneumonic plague transmission following an outbreak and the significance of intervention compliance. (21624780)
2011
9
Levofloxacin cures experimental pneumonic plague in African green monkeys. (21347450)
2011
10
Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague. (20812236)
2010
11
How to reduce the impact of "low-risk patients" following a bioterrorist incident: lessons from SARS, anthrax, and pneumonic plague. (20230231)
2010
12
Perceptions and reactions with regard to pneumonic plague. (20031056)
2010
13
CpG oligodeoxynucleotides augment the murine immune response to the Yersinia pestis F1-V vaccine in bubonic and pneumonic models of plague. (19428836)
2009
14
Pneumonic plague pathogenesis and immunity in Brown Norway rats. (19164505)
2009
15
Induction of innate immunity by lipid A mimetics increases survival from pneumonic plague. (18599840)
2008
16
Current challenges in the development of vaccines for pneumonic plague. (18324890)
2008
17
Oral vaccination with salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague. (17202369)
2007
18
Comparison of 2 antibiotics that inhibit protein synthesis for the treatment of infection with Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague. (17674322)
2007
19
Respiratory immunity is an important component of protection elicited by subunit vaccination against pneumonic plague. (16377037)
2006
20
Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV. (16861680)
2006
21
Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice. (16442673)
2006
22
Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity. (16306265)
2005
23
Structural and functional properties of Yersinia pestis Caf1 capsular antigen and their possible role in fulminant development of primary pneumonic plague. (12645886)
2002
24
Vaccination against bubonic and pneumonic plague. (11457543)
2001
25
A single dose sub-unit vaccine protects against pneumonic plague. (11027822)
2000
26
Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine. (9682370)
1998
27
Protection of mice from fatal bubonic and pneumonic plague by passive immunization with monoclonal antibodies against the F1 protein of Yersinia pestis. (9158060)
1997
28
Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis. (8890210)
1996
29
Surveillance for pneumonic plague in the United States during an international emergency: a model for control of imported emerging diseases. (8964057)
1996
30
Infectivity of pneumonic plague. (7866157)
1995
31
Pneumonic plague in a 15-year-old Utah girl. (8709455)
1995
32
Infectivity of pneumonic plague. (7866091)
1994
33
Alternatives to tetracycline chemoprophylaxis against pneumonic plague. (7841885)
1994
34
From the Centers for Disease Control. Pneumonic plague--Arizona, 1992. (1404753)
1992
35
Pneumonic plague--Arizona, 1992. (1406565)
1992
36
Possible pneumonic plague. (511127)
1979
37
Unusual manifestation of pneumonic plague. (1253262)
1976
38
Serological studies on human plague in Southern Africa. Part II. A bubonic/pneumonic plague epidemic in Lesotho. (935988)
1976
39
A mixed pneumonic bubonic plague outbreak in Vietnam. (4963118)
1967
40
Laboratory-acquired pneumonic plague. Report of a case and review of previous cases. (13874924)
1962
41
Pneumonic plague. (14473142)
1961
42
Pneumonic plague in mice: modification of the infection by antibody against specific components of Pasteurella pestis. (13631291)
1959
43
The development of pneumonic plague in mice and the effect of paralysis of respiratory cilia upon the course of infection. (13439204)
1957
44
Studies on immunization against plague. VIII. Study of three immunizing preparations in protecting primates against pneumonic plague. (14367884)
1955
45
Chloramphenicol and terramycin in the treatment of pneumonic plague. (13030486)
1953
46
Antibiotics in the treatment of bubonic and pneumonic plague in man. (13139207)
1952
47
Pneumonic plague cases in Calcutta and Gaya. (18152327)
1949
48
Primary pneumonic plague in Mukden, 1946, and report of 39 cases with three recoveries. (18898004)
1948
49
Pneumonic plague in Rangoon. (18911234)
1948
50
THE PNEUMONIC PLAGUE IN LOS ANGELES. (18739557)
1925

Genetic Variations for Pneumonic Plague

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Expression for genes affiliated with Pneumonic Plague

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pneumonic Plague

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Pathways for genes affiliated with Pneumonic Plague

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52R&D Systems
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Pathways related to Pneumonic Plague according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1CLEC4A, PRKCD

Compounds for genes affiliated with Pneumonic Plague

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44Novoseek
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Compounds related to Pneumonic Plague according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1n-acetylglucosamine449.1CLEC4A, CHST3
2mannose449.0LY75, CLEC4A
3galactose448.9CLEC4A, CHST3

GO Terms for genes affiliated with Pneumonic Plague

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16Gene Ontology
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Molecular functions related to Pneumonic Plague according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:0302469.0LY75, CLEC4A

Products for genes affiliated with Pneumonic Plague

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pneumonic Plague

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet