MCID: PNM005
MIFTS: 34

Pneumonic Plague malady

Infectious category

Summaries for Pneumonic Plague

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A plague that results in infection located in lung, which results from direct inhalation of the bacillus and has symptom fever, has symptom chills, has symptom cough and has symptom difficulty breathing.

MalaCards: Pneumonic Plague, also known as secondary pneumonic plague, is related to septicemic plague and tuberculosis, and has symptoms including fever, chills and cough. An important gene associated with Pneumonic Plague is CHST3 (carbohydrate (chondroitin 6) sulfotransferase 3), and among its related pathways is Toll-Like receptor Signaling Pathways. The compounds n-acetylglucosamine and mannose have been mentioned in the context of this disorder. Affiliated tissues include lung, lung and spleen.

Wikipedia:64 Pneumonic plague, a severe type of lung infection, is one of three main forms of plague, all of which... more...

Aliases & Classifications for Pneumonic Plague

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

pneumonic plague 8 10 61
secondary pneumonic plague 8 61
primary pneumonic plague 8 61
pneumonic plague, unspecified 8


External Ids:

Disease Ontology8 DOID:10398
ICD9CM27 020.3
ICD1025 A20.2

Related Diseases for Pneumonic Plague

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pneumonic Plague via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1septicemic plague10.2
2tuberculosis10.2
3septic shock10.2

Clinical Features for Pneumonic Plague

Sources:
8Disease Ontology
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Symptoms:

8 (see all 4)
  • fever
  • chills
  • cough
  • difficulty breathing

Drugs & Therapeutics for Pneumonic Plague

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pneumonic Plague

Drug clinical trials:

Search ClinicalTrials for Pneumonic Plague

Search NIH Clinical Center for Pneumonic Plague

Search CenterWatch for Pneumonic Plague

Genetic Tests for Pneumonic Plague

Anatomical Context for Pneumonic Plague

Sources:
14FMA, 33MalaCards
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MalaCards organs/tissues related to Pneumonic Plague:

33
Lung, Spleen, T cells

FMA organs/tissues related to Pneumonic Plague:

14
Lung

Animal Models for Pneumonic Plague or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Pneumonic Plague

Sources:
51PubMed
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Articles related to Pneumonic Plague:

(show top 50)    (show all 139)
idTitleAuthorsYear
1
A cluster of primary pneumonic plague transmitted in a truck cab in a new enzootic focus in China. (23509116)
2013
2
Early apoptosis of macrophages modulated by injection of Yersinia pestis YopK promotes progression of primary pneumonic plague. (23633954)
2013
3
Phagocytes and humoral immunity to pneumonic plague. (22782760)
2012
4
An encapsulated Yersinia pseudotuberculosis is a highly efficient vaccine against pneumonic plague. (22348169)
2012
5
Lessons learned about pneumonic plague diagnosis from two outbreaks, Democratic Republic of the Congo. (21529384)
2011
6
Outer membrane protein X (Ail) contributes to Yersinia pestis virulence in pneumonic plague and its activity is dependent on the lipopolysaccharide core length. (20837715)
2010
7
Using syndromic surveillance systems to detect pneumonic plague. (19698212)
2010
8
Septic shock and nonpulmonary organ dysfunction in pneumonic plague: the role of Yersinia pestis pCD1- vs. pgm- virulence factors. (20400901)
2010
9
The yersiniabactin transport system is critical for the pathogenesis of bubonic and pneumonic plague. (20160020)
2010
10
Biosafety level 2 model of pneumonic plague and protection studies with F1 and Psa. (20498260)
2010
11
A parenteral DNA vaccine protects against pneumonic plague. (20197132)
2010
12
Deletion of Braun lipoprotein gene (lpp) and curing of plasmid pPCP1 dramatically alter the virulence of Yersinia pestis CO92 in a mouse model of pneumonic plague. (19589835)
2009
13
An IL-12 DNA vaccine co-expressing Yersinia pestis antigens protects against pneumonic plague. (18955097)
2009
14
Characterization of the rat pneumonic plague model: infection kinetics following aerosolization of Yersinia pestis CO92. (19073275)
2009
15
Immunization with recombinant V10 protects cynomolgus macaques from lethal pneumonic plague. (18794281)
2008
16
Antibodies and cytokines independently protect against pneumonic plague. (18926869)
2008
17
Lipid A mimetics are potent adjuvants for an intranasal pneumonic plague vaccine. (18722493)
2008
18
Modelling outbreak control for pneumonic plague. (17121692)
2007
19
Delayed inflammatory response to primary pneumonic plague occurs in both outbred and inbred mice. (17101642)
2007
20
Pneumonic plague, northern India, 2002. (17561574)
2007
21
Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plague. (17101198)
2007
22
Oral vaccination with salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague. (17202369)
2007
23
Respiratory immunity is an important component of protection elicited by subunit vaccination against pneumonic plague. (16377037)
2006
24
Administration of antibody to the lung protects mice against pneumonic plague. (16622253)
2006
25
Pneumonic plague cluster, Uganda, 2004. (16704785)
2006
26
Protection against bubonic and pneumonic plague with a single dose microencapsulated sub-unit vaccine. (16546306)
2006
27
Epidemiological and diagnostic aspects of the outbreak of pneumonic plague in Madagascar. (10675169)
2000
28
Lessons Learned from History on Mode of Transmission for Control of Pneumonic Plague. (11095865)
2000
29
Intra nasal administration of poly-lactic acid microsphere co-encapsulated Yersinia pestis subunits confers protection from pneumonic plague in the mouse. (9562689)
1998
30
A sub-unit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunized animals against pneumonic plague. (9269050)
1997
31
Pathology of experimental pneumonic plague produced by fraction 1-positive and fraction 1-negative Yersinia pestis in African green monkeys (Cercopithecus aethiops). (8712895)
1996
32
Infectivity of pneumonic plague. (7866157)
1995
33
Cat-transmitted fatal pneumonic plague in a person who traveled from Colorado to Arizona. (8059908)
1994
34
Pneumonic plague--Arizona, 1992. (1406565)
1992
35
Richard Pearson Strong and the Manchurian epidemic of pneumonic plague, 1910-1911. (2671146)
1989
36
Pneumonic plague in monkeys. An electron microscopic study. (4974722)
1969
37
Pneumonic plague in an untreated plague-vaccinated individual. (6072311)
1967
38
Pneumonic plague in mice: gross and histopathology in untreated and passively immunized animals. (13631290)
1959
39
The first recorded epidemic of pneumonic plague; the Bible, I Sam. VI. (13240296)
1955
40
Studies on the antibody patterns in pneumonic plague patients. (14354242)
1955
41
Chronic pneumonic plague in Macaca mulatta. (13207558)
1954
42
Hepatic function and other physiologic studies in monkeys with experimental pneumonic plague. (13212121)
1954
43
Bubonic septicemic and pneumonic plague. (14828269)
1951
44
Prophylactic immunization and specific therapy of experimental pneumonic plague. (18913803)
1948
45
Primary pneumonic plague in Mukden, 1946, and report of 39 cases with three recoveries. (18898004)
1948
46
Pneumonic plague; a report of recovery in a proved case and a note on sulfadiazine prophylaxis. (18859822)
1948
47
Pneumonic plague. (18857150)
1948
48
The Second Pneumonic Plague Epidemic in Manchuria, 1920-21: I. A General Survey of the Outbreak and Its Course. (20474780)
1923
49
AN EPIDEMIC OF PNEUMONIC PLAGUE. (18010342)
1920
50
FOUR CASES OF PNEUMONIC PLAGUE. (20765317)
1910

Genetic Variations for Pneumonic Plague

Expression for genes affiliated with Pneumonic Plague

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pneumonic Plague

Search GEO for disease gene expression data for Pneumonic Plague.

Pathways for genes affiliated with Pneumonic Plague

Sources:
53R&D Systems
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Pathways related to Pneumonic Plague according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1CLEC4A, PRKCD

Compounds for genes affiliated with Pneumonic Plague

Sources:
45Novoseek
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Compounds related to Pneumonic Plague according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1n-acetylglucosamine459.1CLEC4A, CHST3
2mannose459.0LY75, CLEC4A
3galactose458.9CLEC4A, CHST3

GO Terms for genes affiliated with Pneumonic Plague

Sources:
16Gene Ontology
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Molecular functions related to Pneumonic Plague according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:0302469.0LY75, CLEC4A

Products for genes affiliated with Pneumonic Plague

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pneumonic Plague

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet