MCID: PNM008
MIFTS: 55

Pneumothorax malady

Respiratory diseases category

Summaries for Pneumothorax

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 A pneumothorax (pl. pneumothoraces) is an abnormal collection of air or gas in the pleural space that... more...

MalaCards: Pneumothorax is related to endometriosis and lymphangioleiomyomatosis. An important gene associated with Pneumothorax is FLCN (folliculin), and among its related pathways are Platelet degranulation and FOXA1 transcription factor network. The drug talc and the compounds goserelin and gestrinone have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and breast, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Pneumothorax

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

pneumothorax 8 10 44 60


External Ids:

Disease Ontology8 DOID:1673
MeSH34 D011030
ICD9CM27 512.8
ICD1025 J93, J93.9

Related Diseases for Pneumothorax

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pneumothorax via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1endometriosis30.7CCL11, GNRH1, MUC16, PGR, ESR1
2lymphangioleiomyomatosis30.6PGR, ESR1, TSC1
3pneumonia30.5CCL11, LBP, TEF, SERPINA1, SERPINB1, ELANE
4pulmonary emphysema30.5SERPINA1, SERPINB1, ELANE
5marfan syndrome30.2CD36, FBN1
6spontaneous pneumothorax30.1FLCN
7pulmonary fibrosis30.1SOD1, CD36, ELANE
8tuberous sclerosis30.0TSC1
9hepatitis30.0CCL11, SERPINA1
10myocardial infarction30.0CCL11, LBP
11respiratory failure30.0TSC1, SERPINA1
12asthma30.0CCL11, LBP, SERPINA1, ELANE
13sarcoidosis30.0CCL11
14peritonitis29.9LBP, MUC16
15cystic fibrosis29.9ELANE, SERPINA1, LBP
16alpha 1-antitrypsin deficiency29.9ELANE, SERPINB1, SERPINA1
17meningitis29.7LBP
18esophagitis29.7CCL11
19aortic aneurysm29.7FBN1
20tracheal stenosis29.7TEF
21arthritis29.7FBN1, LBP
22leukemia29.7TEF, CCL11
23adult respiratory distress syndrome29.7LBP, SERPINA1, ELANE
24angiomyolipoma29.7TSC1, ESR1, PGR
25papillary carcinoma29.7ESR1, PGR, MUC16
26leiomyoma29.7CCL11, GNRH1, FLCN, PGR, ESR1
27rheumatoid arthritis29.7CCL11, LBP, CD36, SERPINA1, ELANE
28breast cancer29.7CCL11, GNRH1, MUC16, PGR, SERPINA1, ESR1
29spontaneous tension pneumothorax10.5
30primary spontaneous pneumothorax10.4
31pulmonary edema10.4
32tuberculosis10.4
33interstitial emphysema10.4
34tuberculous pneumothorax10.4
35miliary tuberculosis10.3
36blastoma10.2
37silicosis10.2
38histiocytosis10.2
39bronchiolitis10.2
40langerhans-cell histiocytosis10.2
41sarcoma10.2
42bronchiolitis obliterans10.2
43pleuropulmonary blastoma10.2
44birt-hogg-dube syndrome10.2
45bronchopneumonia10.2
46horner's syndrome10.2
47lung cancer10.2
48mediastinitis10.2
49hemopneumothorax10.1
50aspergillosis10.1

Graphical network of the top 20 diseases related to Pneumothorax:



Diseases related to pneumothorax

Clinical Features for Pneumothorax

About this section

Drugs & Therapeutics for Pneumothorax

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pneumothorax

Drug clinical trials:

Search ClinicalTrials for Pneumothorax

Search NIH Clinical Center for Pneumothorax

Search CenterWatch for Pneumothorax

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pneumothorax

About this section

Anatomical Context for Pneumothorax

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Pneumothorax:

32
Lung, Testes, Breast, Liver, Kidney, Colon, Skin, Heart, Spinal cord, Spleen, Lymph node, Thyroid, Bone, Bone marrow

Animal Models for Pneumothorax or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pneumothorax:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.3FBN1, GPBAR1
2MP:00053679.9TSC1, ESR1, CD36, FLCN, FBN1, GNRH1
3MP:00020069.8GNRH1, FLCN, PGR, ESR1, TSC1, ELANE
4MP:00053709.8GNRH1, SOD1, LBP, CD36, GPBAR1, ESR1
5MP:00053979.5FBN1, SOD1, GNRH1, CCL11, FLCN, CD36
6MP:00053879.5CCL11, GNRH1, SOD1, LBP, FBN1, FLCN
7MP:00053909.4GNRH1, SOD1, FBN1, CD36, PGR, ESR1
8MP:00053769.2ELANE, GNRH1, SOD1, LBP, FBN1, FLCN

Publications for Pneumothorax

About this section
Sources:
50PubMed
See all sources

Articles related to Pneumothorax:

(show top 50)    (show all 1192)
idTitleAuthorsYear
1
How reliable are clinical criteria to distinguish between BHD and smoking as a cause for pneumothorax? (24383416)
2014
2
Pneumothorax volume expansion in helicopter emergency medical services transport. (23632222)
2013
3
Acupuncture-associated pneumothorax. (23317392)
2013
4
Clinical characteristics and prevalence of pneumothorax in patients with pulmonary Mycobacterium avium complex disease. (23196652)
2013
5
Elimination of pneumothorax and hemothorax during placement of implantable venous access ports using ultrasound and fluoroscopic guidance. (23493277)
2013
6
Pulmonary interstitial emphysema after resolution of relapsing pneumothorax and discontinuation of mechanical ventilation. An atypical case in a preterm infant. (24245490)
2013
7
Spontaneous pneumothorax as the initial manifestation of stage IB primary pulmonary carcinoma: really early stage cancer? (24135243)
2013
8
Clinical analysis of patients with pulmonary nontuberculous mycobacterial disease complicated by pneumothorax. (24240789)
2013
9
Tension Pneumothorax, Pneumoperitoneum, and Cervical Emphysema following a Diagnostic Colonoscopy. (23819071)
2013
10
Occult traumatic loculated tension pneumothorax--a sonographic diagnostic dilemma. (22920267)
2013
11
Pneumothorax following extended latissimus dorsi flap breast reconstruction: rare complication or coincidence? (23746660)
2013
12
Spontaneous pneumothorax following caesarean section under spinal anaesthesia. (23761604)
2013
13
Video-assisted thoracoscopic surgery for recurrent pneumothorax in pulmonary lymphangioleimyomatosis with tuberous sclerosis complex. (23597154)
2013
14
Chest x-ray quiz. Persistent cough following a "flu-like" illness. Answer: Chest x-ray reveals a small right apical pneumothorax. (23586100)
2013
15
Apical bullae and spontaneous pneumothorax. (23435384)
2013
16
M-mode ultrasound for the detection of pneumothorax during helicopter transport. (22033387)
2012
17
Awake thoracic surgery for secondary spontaneous pneumothorax: another advancement. (23140968)
2012
18
Bilateral tension pneumothorax. (22345323)
2012
19
Re-expansion pulmonary edema in a patient with total pneumothorax: a hazardous outcome. (22627959)
2012
20
Automated quantification of pneumothorax in CT. (23082091)
2012
21
Bilateral spontaneous pneumothorax, pneumomediastinum, and subcutaneous emphysema: rare and fatal complications of asthma. (23326706)
2012
22
Combined spontaneous contralateral pneumothorax and post-pneumonectomy mediastinal shift-associated dextrocardia. (21243579)
2011
23
Intraoperative pneumothorax identified with transthoracic ultrasound. (21792051)
2011
24
Occurrence of a simultaneous bilateral spontaneous pneumothorax due to a pleuro-pleural communication. (21871318)
2011
25
Life-Threatening Simultaneous Bilateral Spontaneous Tension Pneumothorax - A case report -. (22263163)
2011
26
Spontaneous pneumothorax after traumatic pneumonectomy: a role for talc pleurodesis in secondary prevention? (21718823)
2011
27
Spontaneous pneumothorax-a rare complication of pregnancy. (21281002)
2011
28
Short-term safety of thoracoscopic talc pleurodesis for recurrent primary spontaneous pneumothorax: a prospective European multicentre study. (21436351)
2011
29
Spontaneous pneumothorax management. (21186751)
2010
30
Evaluation of a thoracic ultrasound training module for the detection of pneumothorax and pulmonary edema by prehospital physician care providers. (19138397)
2009
31
Treatment of spontaneous pneumothorax by means of continuous intrapleural suction. 1952. (20162807)
2009
32
Outpatient management of primary spontaneous pneumothorax in the emergency department of a community hospital using a small-bore catheter and a Heimlich valve. (19438414)
2009
33
The impact of smoking in primary spontaneous pneumothorax. (19577078)
2009
34
A Japanese family with multiple lung cysts and recurrent pneumothorax: a possibility of Birt-Hogg-DubAc syndrome. (19687589)
2009
35
Thoracoscopic apico-posterior transmediastinal approach for bilateral spontaneous pneumothorax. (18187456)
2008
36
Secondary spontaneous pneumothorax associated with emphysema and ruptured bullae at the azygoesophageal recess. (19002752)
2008
37
Spontaneous pneumothorax in Wegener's granulomatosis: a case report. (18161001)
2008
38
Novel method for bulla detection with video-assisted thoracoscopic surgery in patients with spontaneous pneumothorax. (18462946)
2008
39
Spontaneous pneumothorax in metastatic thyroid papillary carcinoma. (17577042)
2007
40
Thoracoscopic parietal pleural argon beam coagulation versus pleural abrasion in the treatment of primary spontaneous pneumothorax. (16337391)
2006
41
Management of pneumothorax in lymphangioleiomyomatosis: effects on recurrence and lung transplantation complications. (16685019)
2006
42
Catamenial pneumothorax: chest X-ray sign and thoracoscopic treatment. (12173845)
2002
43
Giant bronchogenic cyst masquerading as tension pneumothorax. Radiographic and CT findings. (9391730)
1997
44
Bilateral spontaneous pneumothorax as the presenting feature in lymphangioleiomyomatosis. (7638376)
1995
45
Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax. (7945061)
1994
46
Catamenial pneumothorax: case report and literature review. (3298683)
1987
47
Catamenial pneumothorax in sisters. (7297159)
1981
48
Catamenial pneumothorax. (7418467)
1980
49
Catamenial pneumothorax: case report and a review of the literature. (453721)
1979
50
Pulmonary alveolar proteinosis presenting with pneumothorax. (6073913)
1967

Genetic Variations for Pneumothorax

About this section

Expression for genes affiliated with Pneumothorax

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pneumothorax

Search GEO for disease gene expression data for Pneumothorax.

Pathways for genes affiliated with Pneumothorax

About this section
Sources:
53Reactome, 37NCBI BioSystems Database
See all sources

Pathways related to Pneumothorax according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2SERPINA1, CD36, SOD1
210.2ESR1, SERPINA1, SOD1
3
Hide members
9.6CCL11, GNRH1, FBN1, PGR, WNT10A, GPBAR1

Compounds for genes affiliated with Pneumothorax

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
See all sources

Compounds related to Pneumothorax according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1goserelin44 28 1112.8GNRH1
2gestrinone4410.7GNRH1, PGR
3Ethynodiol Diacetate1110.7ESR1, PGR
4ici 1643844410.6PGR, ESR1
5psgag4410.6CD36, ELANE
6Etonogestrel1110.6PGR, ESR1
7desmosine4410.6ELANE, SERPINA1, FBN1
8hocl4410.6ELANE, SERPINA1, SOD1
9idoxifene4410.6PGR, ESR1
10Allylestrenol1110.6PGR, ESR1
11estradiol benzoate4410.6ESR1, PGR, GNRH1
12leuprolide acetate4410.6ESR1, GNRH1, PGR
13triphenylethylene4410.6PGR, ESR1
14toremifene44 1111.6PGR, GNRH1, ESR1
15clomiphene citrate4410.6GNRH1, PGR, ESR1
16tibolone4410.6ESR1, PGR, GNRH1
17danazol44 11 2412.6PGR, ESR1, GNRH1
18luminol4410.5SOD1, CCL11
19flutamide44 59 1112.5PGR, ESR1, GNRH1
20safranin o4410.5CD36, GNRH1
21fluticasone propionate44 49 59 1113.5ELANE, PGR, CCL11
22vitamin a44 11 2412.5ELANE, SERPINA1
23steroidal4410.5ESR1, GNRH1, PGR
24raloxifene44 28 49 1113.5ESR1, PGR, CD36, GNRH1
25h2o24410.5SERPINB1, MUC16, CD36
26diethylstilbestrol44 28 1112.5GNRH1, ESR1, PGR
27norgestimate44 1111.4PGR, ESR1
28progestins4410.4ESR1, PGR, GNRH1
29hyaluronic acid44 2411.4CD36, FBN1, CCL11, ELANE, MUC16
30dmso4410.4GNRH1, PGR, CD36, SOD1
31gnrh4410.4ESR1, GNRH1, CD36, GPBAR1, PGR
32serine4410.4FBN1, LBP, TSC1, MUC16, GPBAR1
33superoxide44 2411.3SERPINB1, ELANE, LBP
34medroxyprogesterone44 49 28 11 2414.3PGR, ESR1
35peroxynitrite4410.3SOD1, SERPINA1, CCL11
36creatinine4410.3GNRH1, SOD1, LBP, MUC16, CD36, SERPINA1
37etidronate4410.3GNRH1, CD36
38paraffin4410.3ESR1, TSC1, SERPINA1, CD36, MUC16, PGR
39ibandronate44 1111.3ESR1, CD36
40heparin44 28 11 2413.2GNRH1, CD36, LBP, FBN1, ELANE, SERPINA1
41alanine4410.2CCL11, GNRH1, SOD1, PGR, TSC1, FBN1
42progesterone44 59 28 11 2414.2ESR1, SERPINA1, PGR, MUC16, FBN1, GNRH1
435fluorouracil4410.2ESR1, PGR, CD36, GNRH1
44dexamethasone44 49 28 1113.2MUC16, CD36, GNRH1, PGR, CCL11, LBP
45teriparatide44 1111.2ESR1, CD36
46retinoic acid44 2411.1CD36, FBN1, GNRH1, PGR, ESR1, ELANE
47vegf4410.1MUC16, CCL11, TSC1, ESR1, PGR, CD36
48cysteine4410.1ELANE, SERPINA1, PGR, CD36, PPCS, SOD1
49estrogen4410.1SERPINA1, PGR, GNRH1, ESR1, ELANE, CD36
50trilostane44 1111.0ESR1, PGR

GO Terms for genes affiliated with Pneumothorax

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.7GNRH1, SOD1, LBP, FBN1, WNT10A, SERPINA1
2extracellular spaceGO:0056159.2SERPINB1, CCL11, GNRH1, SOD1, LBP, FBN1

Biological processes related to Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:00257610.2SERPINA1, CD36, SOD1
2cellular response to lipoteichoic acidGO:07122310.2CD36, LBP
3negative regulation of growth of symbiont in hostGO:04413010.2ELANE, CD36, LBP
4negative regulation of gene expressionGO:0106299.9FLCN, PGR, ESR1

Products for genes affiliated with Pneumothorax

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pneumothorax

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet