MCID: PNM008
MIFTS: 55

Pneumothorax malady

Respiratory diseases category

Summaries for Pneumothorax

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63Wikipedia, 32MalaCards
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Wikipedia:63 A pneumothorax (pl. pneumothoraces) is an abnormal collection of air or gas in the pleural space that... more...

MalaCards: Pneumothorax is related to endometriosis and lymphangioleiomyomatosis. An important gene associated with Pneumothorax is FLCN (folliculin), and among its related pathways are Platelet degranulation and FOXA1 transcription factor network. The drug talc and the compounds goserelin and gestrinone have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and testes, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Pneumothorax

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

pneumothorax 8 10 44 60


External Ids:

Disease Ontology8 DOID:1673
MeSH34 D011030
ICD9CM27 512.8
ICD1025 J93, J93.9

Related Diseases for Pneumothorax

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17GeneCards, 18GeneDecks
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Diseases related to Pneumothorax via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1endometriosis30.7CCL11, GNRH1, MUC16, PGR, ESR1
2lymphangioleiomyomatosis30.6PGR, ESR1, TSC1
3pneumonia30.5CCL11, LBP, TEF, SERPINA1, SERPINB1, ELANE
4pulmonary emphysema30.5SERPINA1, SERPINB1, ELANE
5marfan syndrome30.2CD36, FBN1
6spontaneous pneumothorax30.1FLCN
7pulmonary fibrosis30.1SOD1, CD36, ELANE
8tuberous sclerosis30.0TSC1
9hepatitis30.0CCL11, SERPINA1
10myocardial infarction30.0CCL11, LBP
11respiratory failure30.0TSC1, SERPINA1
12asthma30.0CCL11, LBP, SERPINA1, ELANE
13sarcoidosis30.0CCL11
14peritonitis29.9LBP, MUC16
15cystic fibrosis29.9ELANE, SERPINA1, LBP
16alpha 1-antitrypsin deficiency29.9ELANE, SERPINB1, SERPINA1
17meningitis29.7LBP
18esophagitis29.7CCL11
19aortic aneurysm29.7FBN1
20tracheal stenosis29.7TEF
21arthritis29.7FBN1, LBP
22leukemia29.7TEF, CCL11
23adult respiratory distress syndrome29.7LBP, SERPINA1, ELANE
24angiomyolipoma29.7TSC1, ESR1, PGR
25papillary carcinoma29.7ESR1, PGR, MUC16
26leiomyoma29.7CCL11, GNRH1, FLCN, PGR, ESR1
27rheumatoid arthritis29.7CCL11, LBP, CD36, SERPINA1, ELANE
28breast cancer29.7CCL11, GNRH1, MUC16, PGR, SERPINA1, ESR1
29spontaneous tension pneumothorax10.5
30primary spontaneous pneumothorax10.4
31pulmonary edema10.4
32tuberculosis10.4
33interstitial emphysema10.4
34tuberculous pneumothorax10.4
35miliary tuberculosis10.3
36blastoma10.2
37silicosis10.2
38histiocytosis10.2
39bronchiolitis10.2
40langerhans-cell histiocytosis10.2
41sarcoma10.2
42bronchiolitis obliterans10.2
43pleuropulmonary blastoma10.2
44birt-hogg-dube syndrome10.2
45bronchopneumonia10.2
46horner's syndrome10.2
47lung cancer10.2
48mediastinitis10.2
49hemopneumothorax10.1
50aspergillosis10.1

Graphical network of the top 20 diseases related to Pneumothorax:



Diseases related to pneumothorax

Clinical Features for Pneumothorax

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Drugs & Therapeutics for Pneumothorax

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pneumothorax

Drug clinical trials:

Search ClinicalTrials for Pneumothorax

Search NIH Clinical Center for Pneumothorax

Search CenterWatch for Pneumothorax

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pneumothorax

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Anatomical Context for Pneumothorax

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32MalaCards
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MalaCards organs/tissues related to Pneumothorax:

32
Lung, Breast, Testes, Liver, Kidney, Skin, Colon, Bone, Lymph node, Bone marrow, Heart, Thyroid, Spinal cord, Spleen

Animal Models for Pneumothorax or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pneumothorax:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.3FBN1, GPBAR1
2MP:00053679.9TSC1, ESR1, CD36, FLCN, FBN1, GNRH1
3MP:00020069.8GNRH1, FLCN, PGR, ESR1, TSC1, ELANE
4MP:00053709.8GNRH1, SOD1, LBP, CD36, GPBAR1, ESR1
5MP:00053979.5FBN1, SOD1, GNRH1, CCL11, FLCN, CD36
6MP:00053879.5CCL11, GNRH1, SOD1, LBP, FBN1, FLCN
7MP:00053909.4GNRH1, SOD1, FBN1, CD36, PGR, ESR1
8MP:00053769.2ELANE, GNRH1, SOD1, LBP, FBN1, FLCN

Publications for Pneumothorax

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50PubMed
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Articles related to Pneumothorax:

(show top 50)    (show all 1192)
idTitleAuthorsYear
1
VATS bullectomy and apical pleurectomy for spontaneous pneumothorax in a young patient with Swyer-James-Mc Leod syndrome: case report presentation and literature review focusing on surgically treated cases. (24410793)
2014
2
Improvement in the prehospital recognition of tension pneumothorax: the effect of a change to paramedic guidelines and education. (23859653)
2014
3
Quick recertification series. Pneumothorax. (23682458)
2013
4
What Factors Predict Recurrence after an Initial Episode of Primary Spontaneous Pneumothorax in Children? (24284502)
2013
5
Surgery for secondary spontaneous pneumothorax: risk factors for recurrence and morbidity. (23674562)
2013
6
A recommended method in order to interpret chest x-rays for diagnosing small size pneumothorax. (23724383)
2013
7
Risk factors for the development of reexpansion pulmonary edema in patients with spontaneous pneumothorax. (23816309)
2013
8
Vanishing lung syndrome mimicking pneumothorax. (23637346)
2013
9
Non-surgical causes of pneumoperitoneum--characteristic 'Rigler's sign' in a chest x-ray due to pneumothorax with a diaphragmatic hernia. (22718783)
2012
10
Tension pneumothorax at anaesthetic induction in an ex-premature infant with bronchopulmonary dysplasia. (22967679)
2012
11
Pneumothorax following ultrasound guided supraclavicular brachial plexus block. (23225954)
2012
12
Simultaneous minimally invasive surgery for pectus excavatum and recurrent pneumothorax. (22771479)
2012
13
Pediatric spontaneous pneumothorax. (22766594)
2012
14
Evaluation of simple aspiration therapy in the initial treatment for primary spontaneous pneumothorax. (22687837)
2012
15
Spontaneous pneumothorax in a patient with buffalo chest. (22241006)
2012
16
Secondary spontaneous pneumothorax: which associated conditions benefit from pigtail catheter treatment? (20970297)
2012
17
Contralateral pneumothorax following repositioning of an atrial lead. (22016307)
2012
18
Tension pneumothorax and life saving diaphragmatic rupture: a case report and review of the literature. (21806807)
2011
19
Laryngeal fracture due to blunt trauma presenting with pneumothorax and pneumomediastinum. (21822030)
2011
20
Small-bore wire-guided chest drains: safety, tolerability, and effectiveness in pneumothorax, malignant effusions, and pleural empyema. (20947099)
2011
21
Mechanical versus chemical pleurodesis for management of primary spontaneous pneumothorax evaluated with thoracic echography. (21828109)
2011
22
Outcomes of an algorithmic approach to management of pneumothorax complicating thermal ablation of pulmonary neoplasms. (21856506)
2011
23
Anterior versus lateral needle decompression of tension pneumothorax: comparison by computed tomography chest wall measurement. (21951681)
2011
24
Is prophylactic treatment of contralateral blebs in patients with primary spontaneous pneumothorax indicated? (19765740)
2010
25
Perforated ulcer mimicking a spontaneous pneumothorax in a patient with congenital diaphragmatic hernia. (19385305)
2009
26
Poor R-wave progression in the precordial leads in left-sided spontaneous pneumothorax. (19933951)
2009
27
Deviation from published guidelines in the management of primary spontaneous pneumothorax in Australia. (18190419)
2008
28
Horner's syndrome in a patient presenting with a spontaneous pneumothorax. (18212159)
2008
29
Spontaneous pneumothorax: an unusual complication of pregnancy--a case report and review of literature. (19561889)
2008
30
Long-term personalized GnRH agonist therapy without estrogen supplementation for recurrent endometriotic catamenial pneumothorax--case report. (17937096)
2007
31
Spontaneous pneumothorax, pneumomediastinum, and epidural emphysema presenting as neck pain suspicious for meningitis. (17666929)
2007
32
Simple aspiration versus intercostal tube drainage for primary spontaneous pneumothorax in adults. (17253510)
2007
33
Prevalence of mitral valve prolapse in primary spontaneous pneumothorax. (17064962)
2006
34
Pneumothorax and pulmonary cyst in a 2-year-old child. Pleuropulmonary blastoma. (16594758)
2006
35
Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults. (15805188)
2005
36
Self assessment exercises in emergency medicine. Question 4. Spontaneous pneumothorax secondary to a rupture of subpleural bleb. (16444825)
2005
37
Accidentally created tension pneumothorax in patient with primary spontaneous pneumothorax--confirmation of the experimental studies, putting into question the classical explanation. (15533636)
2005
38
Video-assisted thoracoscopic management of recurrent primary spontaneous pneumothorax after prior talc pleurodesis: a feasible, safe and efficient treatment option. (15519177)
2004
39
Pleuropulmonary blastoma: report of a case presenting with spontaneous pneumothorax. (11300091)
2001
40
Birt-Hogg-DubAc syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2. (11533913)
2001
41
Catamenial pneumothorax: an example of porous diaphragm syndromes. (11083721)
2000
42
Primary spontaneous pneumothorax detected during a medical checkup. (10492307)
1999
43
Immediate and long-term results after surgical treatment of primary spontaneous pneumothorax by VATS. (8651762)
1996
44
Pneumothorax as the presenting manifestation of lymphangitis carcinomatosa. (7868496)
1994
45
Risk of pneumothorax not increased by obstructive lung disease in percutaneous needle biopsy. (8205864)
1994
46
Persistent pneumothorax following embolization of a pulmonary arteriovenous malformation. (7873870)
1994
47
Catamenial pneumothorax. (3460579)
1986
48
Spontaneous pneumothorax in allergic bronchopulmonary aspergillosis. (6691749)
1984
49
Management of tuberculous pneumothorax in Nigeria. (448758)
1979
50
Cystic lymphangioma of lungs as result of relapsing tensional pneumothorax]. (13039085)
1952

Genetic Variations for Pneumothorax

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Expression for genes affiliated with Pneumothorax

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pneumothorax

Search GEO for disease gene expression data for Pneumothorax.

Pathways for genes affiliated with Pneumothorax

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Pneumothorax according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2SOD1, CD36, SERPINA1
210.2SOD1, SERPINA1, ESR1
3
Hide members
9.6CCL11, GNRH1, FBN1, PGR, WNT10A, GPBAR1

Compounds for genes affiliated with Pneumothorax

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Pneumothorax according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1goserelin44 28 1112.8GNRH1
2gestrinone4410.7GNRH1, PGR
3Ethynodiol Diacetate1110.7ESR1, PGR
4ici 1643844410.6PGR, ESR1
5psgag4410.6CD36, ELANE
6Etonogestrel1110.6PGR, ESR1
7desmosine4410.6ELANE, SERPINA1, FBN1
8hocl4410.6ELANE, SERPINA1, SOD1
9idoxifene4410.6PGR, ESR1
10Allylestrenol1110.6PGR, ESR1
11estradiol benzoate4410.6ESR1, PGR, GNRH1
12leuprolide acetate4410.6ESR1, GNRH1, PGR
13triphenylethylene4410.6PGR, ESR1
14toremifene44 1111.6PGR, GNRH1, ESR1
15clomiphene citrate4410.6GNRH1, PGR, ESR1
16tibolone4410.6ESR1, PGR, GNRH1
17danazol44 11 2412.6PGR, ESR1, GNRH1
18luminol4410.5SOD1, CCL11
19flutamide44 59 1112.5PGR, ESR1, GNRH1
20safranin o4410.5CD36, GNRH1
21fluticasone propionate44 49 59 1113.5ELANE, PGR, CCL11
22vitamin a44 11 2412.5ELANE, SERPINA1
23steroidal4410.5ESR1, GNRH1, PGR
24raloxifene44 28 49 1113.5ESR1, PGR, CD36, GNRH1
25h2o24410.5SERPINB1, MUC16, CD36
26diethylstilbestrol44 28 1112.5GNRH1, ESR1, PGR
27norgestimate44 1111.4PGR, ESR1
28progestins4410.4ESR1, PGR, GNRH1
29hyaluronic acid44 2411.4CD36, FBN1, CCL11, ELANE, MUC16
30dmso4410.4GNRH1, PGR, CD36, SOD1
31gnrh4410.4ESR1, GNRH1, CD36, GPBAR1, PGR
32serine4410.4FBN1, LBP, TSC1, MUC16, GPBAR1
33superoxide44 2411.3SERPINB1, ELANE, LBP
34medroxyprogesterone44 49 28 11 2414.3PGR, ESR1
35peroxynitrite4410.3SOD1, SERPINA1, CCL11
36creatinine4410.3GNRH1, SOD1, LBP, MUC16, CD36, SERPINA1
37etidronate4410.3GNRH1, CD36
38paraffin4410.3ESR1, TSC1, SERPINA1, CD36, MUC16, PGR
39ibandronate44 1111.3ESR1, CD36
40heparin44 28 11 2413.2GNRH1, CD36, LBP, FBN1, ELANE, SERPINA1
41alanine4410.2CCL11, GNRH1, SOD1, PGR, TSC1, FBN1
42progesterone44 59 28 11 2414.2ESR1, SERPINA1, PGR, MUC16, FBN1, GNRH1
435fluorouracil4410.2ESR1, PGR, CD36, GNRH1
44dexamethasone44 49 28 1113.2MUC16, CD36, GNRH1, PGR, CCL11, LBP
45teriparatide44 1111.2ESR1, CD36
46retinoic acid44 2411.1CD36, FBN1, GNRH1, PGR, ESR1, ELANE
47vegf4410.1MUC16, CCL11, TSC1, ESR1, PGR, CD36
48cysteine4410.1ELANE, SERPINA1, PGR, CD36, PPCS, SOD1
49estrogen4410.1SERPINA1, PGR, GNRH1, ESR1, ELANE, CD36
50trilostane44 1111.0ESR1, PGR

GO Terms for genes affiliated with Pneumothorax

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16Gene Ontology
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Cellular components related to Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.7CCL11, GNRH1, SOD1, LBP, FBN1, WNT10A
2extracellular spaceGO:0056159.2CCL11, GNRH1, SOD1, LBP, FBN1, MUC16

Biological processes related to Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:00257610.2SERPINA1, CD36, SOD1
2cellular response to lipoteichoic acidGO:07122310.2CD36, LBP
3negative regulation of growth of symbiont in hostGO:04413010.2ELANE, CD36, LBP
4negative regulation of gene expressionGO:0106299.9FLCN, PGR, ESR1

Products for genes affiliated with Pneumothorax

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Sources for Pneumothorax

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet