MCID: PNM008
MIFTS: 48

Pneumothorax malady

Respiratory category

Summaries for Pneumothorax

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 A pneumothorax (pl. pneumothoraces) is an abnormal collection of air or gas in the pleural space that... more...

MalaCards: Pneumothorax is related to spontaneous pneumothorax and lymphangioleiomyomatosis. An important gene associated with Pneumothorax is FLCN (folliculin), and among its related pathways are Platelet degranulation and FOXA1 transcription factor network. The drug talc and the compounds goserelin and gestrinone have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Pneumothorax

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory


Aliases & Descriptions:

pneumothorax 8 10 45 61


External Ids:

Disease Ontology8 DOID:1673
MeSH35 D011030
ICD9CM27 512.8
ICD1025 J93, J93.9

Related Diseases for Pneumothorax

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pneumothorax via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1spontaneous pneumothorax31.8FLCN
2lymphangioleiomyomatosis30.7ESR1, PGR, TSC1
3marfan syndrome30.3FBN1, CD36
4asthma30.2CCL11, LBP, SERPINA1, ELANE
5tuberous sclerosis30.1TSC1
6pulmonary disease, chronic obstructive30.1ELANE, CCL11, SERPINB1, SERPINA1
7cystic fibrosis29.9ELANE, SERPINA1, LBP
8bronchopulmonary dysplasia29.9SOD1, ELANE
9aortic aneurysm29.7FBN1
10tracheal stenosis29.7TEF
11adenoma29.7GNRH1, TSC1
12arthritis29.7FBN1, LBP
13adult respiratory distress syndrome29.7SERPINA1, ELANE, LBP
14angiomyolipoma29.7ESR1, PGR, TSC1
15papillary carcinoma29.7PGR, MUC16, ESR1
16primary spontaneous pneumothorax11.0
17catamenial pneumothorax10.9
18spontaneous tension pneumothorax10.5
19birt–hogg–dubé syndrome10.5
20birt-hogg-dub� syndrome10.5
21pulmonary edema10.4
22tuberculosis10.4
23interstitial emphysema10.4
24tuberculous pneumothorax10.4
25miliary tuberculosis10.3
26blastoma10.3
27silicosis10.3
28bronchiolitis10.3
29bronchiolitis obliterans10.2
30pleuropulmonary blastoma10.2
31birt-hogg-dube syndrome10.2
32bronchopneumonia10.2
33horner's syndrome10.2
34hemopneumothorax10.2
35n syndrome10.2
36aspergillosis10.2
37wegener's granulomatosis10.1
38adenocarcinoma10.1
39bronchogenic cyst10.1
40swyer syndrome10.1
41swyer-james syndrome10.1
42allergic bronchopulmonary aspergillosis10.1
43pulmonary tuberculosis10.1
44duodenal ulcer10.1
45ankylosing spondylitis10.1
46rheumatoid lung disease10.1
47adult syndrome10.1
48angiosarcoma10.1
49spondylitis10.1
50synovial sarcoma10.1

Graphical network of the top 20 diseases related to Pneumothorax:



Diseases related to pneumothorax

Clinical Features for Pneumothorax

Drugs & Therapeutics for Pneumothorax

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pneumothorax

Drug clinical trials:

Search ClinicalTrials for Pneumothorax

Search NIH Clinical Center for Pneumothorax

Search CenterWatch for Pneumothorax

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Pneumothorax

Anatomical Context for Pneumothorax

Animal Models for Pneumothorax or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pneumothorax

Sources:
51PubMed
See all sources

Articles related to Pneumothorax:

(show top 50)    (show all 1194)
idTitleAuthorsYear
1
Chemical pleurodesis for spontaneous pneumothorax. (24268613)
2013
2
Sonographic diagnosis of bilateral pneumothorax following an acupuncture session. (23657809)
2013
3
Natural Course of Spontaneous Pneumothorax without Bullae or Blebs under High-Resolution Computed Tomography. (23775414)
2013
4
Isolated familial pneumothorax in a Taiwanese family with Birt-Hogg-DubAc syndrome. (24346394)
2013
5
Uniportal VATS for pneumothorax and interstitial lung disease. (24040528)
2013
6
Simple aspiration and drainage and intrapleural minocycline pleurodesis versus simple aspiration and drainage for the initial treatment of primary spontaneous pneumothorax: an open-label, parallel-group, prospective, randomised, controlled trial. (23489754)
2013
7
Reexpansion pulmonary edema after treatment of simultaneous bilateral spontaneous tension pneumothorax. (23557179)
2013
8
No more tension pneumothorax in unsuccessfully resuscitated patients with penetrating chest trauma at autopsy! (23618783)
2013
9
Endobronchial valve placement for spontaneous pneumothorax from stage IIIA non-small cell lung cancer facilitates neoadjuvant therapy. (24296192)
2013
10
A case of paediatric simulated pneumothorax. (22366040)
2012
11
Bilateral pneumothorax after orthognatic surgery. (23814593)
2012
12
Spontaneous hemo-pneumothorax in a patient with Ehlers-Danlos syndrome. (22610159)
2012
13
Pneumoscrotum as the presenting symptom of pneumothorax and pneumoperitoneum after jet ventilation. (22430121)
2012
14
Surgical access rather than method of pleurodesis (pleurectomy or pleural abrasion) influences recurrence rates for pneumothorax surgery: systematic review and meta-analysis. (22566267)
2012
15
A case of recurrent spontaneous pneumothorax during pregnancy treated with video assisted thoracoscopic surgery. (22891012)
2012
16
Single stage minimally invasive bilateral video assisted thoracoscopic surgery for simultaneous bilateral primary spontaneous pneumothorax. (22822653)
2012
17
Pneumothorax in the critically ill patient. (22474153)
2012
18
Thoracic endometriosis as cause of recurrent pneumothorax. (21920997)
2012
19
Surgical tension pneumothorax during laparoscopic repair of massive hiatus hernia: a different situation requiring different management. (22165368)
2011
20
Chemotherapy-related delayed bilateral spontaneous pneumothorax and lung fibrosis: methotrexate or cyclophosphamide, or both? (20931743)
2010
21
Hard metal pneumoconiosis with spontaneous bilateral pneumothorax. (20209319)
2010
22
Gynecologic evaluation of catamenial pneumothorax associated with endometriosis. (20580323)
2010
23
Spontaneous pneumothorax in a dog secondary to Dirofilaria immitis infection. (21088191)
2010
24
An experience with the modified total pleural covering technique in a patient with bilateral intractable pneumothorax secondary to lymphangioleiomyomatosis. (21263428)
2010
25
Spontaneous pneumothorax during laparoscopy-assisted Billroth-I gastrectomy -A case report-. (20508801)
2010
26
Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature. (20413710)
2010
27
Bilateral spontaneous pneumothorax in a newborn with N1303K mutation of cystic fibrosis (CFTR) gene. (20865572)
2010
28
Video-assisted thoracoscopy for spontaneous pneumothorax after pneumonectomy. (18514025)
2009
29
Electrocardiogram manifestation of spontaneous pneumothorax. (19751635)
2009
30
Spontaneous pneumothorax due to Birt-Hogg-Dube syndrome in a Chinese family. (19659657)
2009
31
Marfan syndrome with multiseptate pneumothorax and mandibular fibrous dysplasia. (20532001)
2009
32
Management of two pregnancies in a woman with mixed connective tissue disease, pulmonary fibrosis, frequent pneumothorax and oxygen inhalation therapy along with a published work review. (18840165)
2008
33
An open and shut case for early VATS treatment of primary spontaneous pneumothorax in children. (17568487)
2007
34
Langerhans cell histiocytosis manifesting as recurrent simultaneous bilateral spontaneous pneumothorax in early infancy. (18045318)
2007
35
Video-assisted thoracoscopic surgery for recurrent spontaneous pneumothorax: the long-term benefit. (16479351)
2006
36
A 4-bp deletion in the Birt-Hogg-Dube gene (FLCN) causes dominantly inherited spontaneous pneumothorax. (15657874)
2005
37
Simple aspiration versus chest-tube insertion in the management of primary spontaneous pneumothorax: a systematic review. (15250222)
2004
38
Secondary spontaneous pneumothorax: catamenial pneumothorax. (12969997)
2003
39
Primary spontaneous pneumothorax in a track athlete. (12394207)
2002
40
New electroablation technique following the first-line stapling method for thoracoscopic treatment of primary spontaneous pneumothorax. (11796458)
2002
41
Miliary tuberculosis with bilateral pneumothorax: a rare complication. (12026252)
2002
42
Can CT scanning be used to select patients with unilateral primary spontaneous pneumothorax for bilateral surgery? (10936128)
2000
43
Pneumothorax and neonatal stroke. (8837079)
1996
44
Successful conservative treatment of catamenial pneumothorax with GnRH agonist. (7574910)
1995
45
A case of sarcoidosis discovered by onset of pneumothorax]. (7791273)
1995
46
Primary spontaneous pneumothorax: a community hospital study. (3698682)
1986
47
Catamenial pneumothorax. (6160041)
1980
48
Miliary tuberculosis complicated by bilateral spontaneous pneumothorax. (13212205)
1954
49
Pulmonary interstitial emphysema, pneumomediastinum, subcutaneous emphysema, and pneumothorax, with the description of a case. (20276679)
1946
50
Tuberculous Pneumothorax treated by Aspiration and Gas Displacement. (19986372)
1928

Genetic Variations for Pneumothorax

Expression for genes affiliated with Pneumothorax

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pneumothorax

Search GEO for disease gene expression data for Pneumothorax.

Pathways for genes affiliated with Pneumothorax

Sources:
54Reactome, 38NCBI BioSystems Database
See all sources

Pathways related to Pneumothorax according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2SOD1, CD36, SERPINA1
210.2SOD1, SERPINA1, ESR1
3
Hide members
9.6CCL11, GNRH1, FBN1, PGR, WNT10A, GPBAR1

Compounds for genes affiliated with Pneumothorax

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB
See all sources

Compounds related to Pneumothorax according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1goserelin45 29 1112.8GNRH1
2gestrinone4510.7GNRH1, PGR
3Ethynodiol Diacetate1110.7PGR, ESR1
4ici 1643844510.6PGR, ESR1
5Allylestrenol1110.6PGR, ESR1
6desmosine4510.6ELANE, SERPINA1, FBN1
7Etonogestrel1110.6PGR, ESR1
8hocl4510.6ELANE, SERPINA1, SOD1
9psgag4510.6CD36, ELANE
10idoxifene4510.6PGR, ESR1
11estradiol benzoate4510.6ESR1, PGR, GNRH1
12leuprolide acetate4510.6GNRH1, PGR, ESR1
13triphenylethylene4510.6ESR1, PGR
14clomiphene citrate4510.6GNRH1, PGR, ESR1
15toremifene45 1111.6GNRH1, PGR, ESR1
16tibolone4510.6ESR1, PGR, GNRH1
17danazol45 11 2412.6GNRH1, PGR, ESR1
18luminol4510.5SOD1, CCL11
19flutamide45 60 1112.5GNRH1, PGR, ESR1
20safranin o4510.5CD36, GNRH1
21fluticasone propionate45 50 60 1113.5CCL11, PGR, ELANE
22vitamin a45 11 2412.5SERPINA1, ELANE
23steroidal4510.5GNRH1, PGR, ESR1
24raloxifene45 29 50 1113.5GNRH1, CD36, PGR, ESR1
25h2o24510.5SERPINB1, CD36, MUC16
26diethylstilbestrol45 29 1112.5ESR1, PGR, GNRH1
27norgestimate45 1111.4PGR, ESR1
28progestins4510.4GNRH1, PGR, ESR1
29hyaluronic acid45 2411.4CCL11, FBN1, MUC16, CD36, ELANE
30dmso4510.4GNRH1, SOD1, CD36, PGR
31gnrh4510.4GNRH1, CD36, PGR, GPBAR1, ESR1
32serine4510.4LBP, FBN1, MUC16, GPBAR1, TSC1
33superoxide45 2411.3ELANE, SERPINB1, LBP
34medroxyprogesterone45 50 29 11 2414.3PGR, ESR1
35peroxynitrite4510.3CCL11, SOD1, SERPINA1
36creatinine4510.3GNRH1, SOD1, LBP, MUC16, CD36, SERPINA1
37paraffin4510.3MUC16, CD36, PGR, SERPINA1, ESR1, TSC1
38trilostane45 1111.3ESR1, PGR
39teriparatide45 1111.3CD36, ESR1
40heparin45 29 11 2413.2ELANE, CCL11, GNRH1, LBP, FBN1, CD36
41alanine4510.2CCL11, GNRH1, SOD1, LBP, FBN1, PGR
42progesterone45 60 29 11 2414.2GNRH1, FBN1, MUC16, PGR, SERPINA1, ESR1
435fluorouracil4510.2ESR1, PGR, CD36, GNRH1
44dexamethasone45 50 29 1113.2CCL11, GNRH1, LBP, MUC16, CD36, PGR
45etidronate4510.2GNRH1, CD36
46retinoic acid45 2411.1CCL11, GNRH1, FBN1, CD36, PGR, ESR1
47vegf4510.1CCL11, MUC16, CD36, PGR, ESR1, TSC1
48cysteine4510.1SOD1, PPCS, FBN1, CD36, PGR, SERPINA1
49estrogen4510.1GNRH1, FBN1, MUC16, CD36, PGR, SERPINA1
50ibandronate45 1111.0ESR1, CD36

GO Terms for genes affiliated with Pneumothorax

Sources:
16Gene Ontology
See all sources

Cellular components related to Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.7CCL11, GNRH1, SOD1, LBP, FBN1, WNT10A
2extracellular spaceGO:0056159.2CCL11, GNRH1, SOD1, LBP, FBN1, MUC16

Biological processes related to Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:00257610.2SERPINA1, CD36, SOD1
2cellular response to lipoteichoic acidGO:07122310.2CD36, LBP
3negative regulation of growth of symbiont in hostGO:04413010.2ELANE, CD36, LBP
4negative regulation of gene expressionGO:0106299.9FLCN, PGR, ESR1

Products for genes affiliated with Pneumothorax

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pneumothorax

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet