MCID: PDC001
MIFTS: 36

Podoconiosis malady

Category: Immune diseases

Aliases & Classifications for Podoconiosis

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Aliases & Descriptions for Podoconiosis:

Name: Podoconiosis 51 11 13 67
 
Podoconiosis, Susceptibility to 12

Classifications:



External Ids:

OMIM51 614590
Disease Ontology11 DOID:0050138

Summaries for Podoconiosis

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OMIM:51 Podoconiosis, or endemic nonfilarial elephantiasis, is a noninfectious geochemical disease characterized by edema of... (614590) more...

MalaCards based summary: Podoconiosis, also known as podoconiosis, susceptibility to, is related to osteogenesis imperfecta congenita, microcephaly, and cataracts and fruit allergy. An important gene associated with Podoconiosis is PDCOS (Podoconiosis, Susceptibility To), and among its related pathways are Tuberculosis and Toxoplasmosis. Affiliated tissues include skin and testes, and related mouse phenotype integument.

Wikipedia:70 Podoconiosis, also known as nonfilarial elephantiasis, is a disease of the lymph vessels of the lower... more...

Related Diseases for Podoconiosis

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Diseases related to Podoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1osteogenesis imperfecta congenita, microcephaly, and cataracts10.6HLA-DQA1, HLA-DQB1
2fruit allergy10.5HLA-DQB1, HLA-DRB1
3panuveitis10.5HLA-DQA1, HLA-DRB1
4quinquaud's decalvans folliculitis10.5HLA-DQB1, HLA-DRB1
5pediatric systemic lupus erythematosus10.5HLA-DQB1, HLA-DRB1
6vitreoretinochoroidopathy dominant10.5HLA-DQB1, HLA-DRB1
7krieble bixler syndrome10.4HLA-DQB1, HLA-DRB1
8spondylarthropathy10.4HLA-DQB1, HLA-DRB1
9mitochondrial encephalomyopathy10.4HLA-DQB1, HLA-DRB1
10rheumatic myocarditis10.4HLA-DQB1, HLA-DRB1
11nebulin-related early-onset distal myopathy10.4HLA-DQB1, HLA-DRB1
12purpura fulminans10.4HLA-DQB1, HLA-DRB1
13lymphocytic colitis10.4HLA-DQB1, HLA-DRB1
14peripheral t-cell lymphoma10.4HLA-DQB1, HLA-DRB1
15thrombocytopenia due to platelet alloimmunization10.4HLA-DQB1, HLA-DRB1
16orbit alveolar rhabdomyosarcoma10.4HLA-DQB1, HLA-DRB1
17wolffian duct adenocarcinoma10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
18parsonage turner syndrome10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
19lipodermatosclerosis10.3HLA-DQB1, HLA-DRB1
20myopathy-growth delay-intellectual disability-hypospadias syndrome10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
21renovascular hypertension10.3HLA-DQA1, HLA-DRB1, MBL2
22ovarian papillary cystadenoma10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
23elephantiasis10.3
24aseptic osteitis10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
25oculogyric crisis10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
26multicentric castleman disease10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
27x-linked congenital generalized hypertrichosis10.3HLA-DQB1, HLA-DRB1
28achilles bursitis10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
29lethal midline granuloma10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
30cerebral primitive neuroectodermal tumor10.3CD68, HBA1
31temporal lobe neoplasm10.2CD68, HBA1
32malignant type ab thymoma10.2CD68, HBA1
33spinal cord astrocytoma10.2CD68, HBA1
34spindle cell liposarcoma10.2CD68, HBA1
35breast intracanalicular fibroadenoma10.2HBA1, PDPN
36breast secretory carcinoma10.2HBA1, PDPN
37cholelithiasis10.2CD68, HBA1
38filarial elephantiasis10.2
39selective igm deficiency disease10.2HLA-DQA1, HLA-DQB1
40glutathionuria10.2HLA-DQB1, HLA-DQB2
41adult cerebellar neoplasm10.1HBA1, PDPN
42idiopathic central precocious puberty10.1HLA-DQB1, HLA-DRB1
43mononeuritis of upper limb10.1HLA-DQB1, HLA-DRB1
44foster-kennedy syndrome10.1HLA-DQB1, HLA-DQB2, HLA-DRB1
45connective tissue benign neoplasm10.1CD68, HBA1
46papillary adenoma10.0CD68, HBA1
47cervix uteri carcinoma in situ9.9HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
48leydig cell tumor9.9HBA1, PDPN
49lymphedema9.9
50filariasis9.9

Graphical network of the top 20 diseases related to Podoconiosis:



Diseases related to podoconiosis

Symptoms for Podoconiosis

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Clinical features from OMIM:

614590

Drugs & Therapeutics for Podoconiosis

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Drugs for Podoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PetrolatumapprovedPhase 3898009-03-8
Synonyms:
Multi-hydrocarbon
Paraffinum album
Paraffinum flavum
Petrolatum base
Petrolatum, white
 
Petrolatum,amber
Petrolatum,white
Petroleum jelly
Soft paraffin
White petrolatum
White, soft paraffin
Yellow soft paraffin
2
Glycerolexperimental, approvedPhase 322356-81-5753
Synonyms:
1,2,3-Trihydroxypropane
1,2,3-propanetriol
1,2,3-trihydroxypropane
Bulbold
Cristal
E 422
Emery 916
Glyceol Opthalgan
Glycerin
Glycerin, anhydrous
Glycerin,anhydrous
Glycerine
Glycerinum
 
Glyceritol
Glycerol
Glycyl alcohol
Glyrol
Glysanin
IFP
Incorporation factor
Mackstat H 66
Monoctanoin component D
Osmoglyn
Pricerine 9091
Propanetriol
RG-S
Trihydroxypropane
Tryhydroxypropane
3Sodium hypochloritePhase 342
4Protective AgentsPhase 37190
5DisinfectantsPhase 3547
6Anti-Infective AgentsPhase 321402
7EusolPhase 342

Interventional clinical trials:

idNameStatusNCT IDPhase
1An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With PodoconiosisCompletedNCT02839772Phase 3
2Promoting Consistent Shoe Use Among Children At High Risk for PodoconiosisCompletedNCT01160523
3Genetic and Other Aspects of PodoconiosisNot yet recruitingNCT01939431

Search NIH Clinical Center for Podoconiosis

Genetic Tests for Podoconiosis

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Anatomical Context for Podoconiosis

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MalaCards organs/tissues related to Podoconiosis:

35
Skin, Testes

Animal Models for Podoconiosis or affiliated genes

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MGI Mouse Phenotypes related to Podoconiosis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.6CDKAL1, PAH, PDPN, PPARA, RUNX1T1, SDC1

Publications for Podoconiosis

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Articles related to Podoconiosis:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Willingness to pay for footwear, and associated factors related to podoconiosis in northern Ethiopia. (27620919)
2016
2
Dual Perspectives On Stigma: Reports of Experienced and Enacted Stigma by Those Affected and Unaffected by Podoconiosis. (27747202)
2016
3
Burden assessment of podoconiosis in Wayu Tuka woreda, east Wollega zone, western Ethiopia: a community-based cross-sectional study. (27670520)
2016
4
Detecting and staging podoconiosis cases in North West Cameroon: positive predictive value of clinical screening of patients by community health workers and researchers. (27650390)
2016
5
Using Qualitative Methods to Explore Lay Explanatory Models, Health-Seeking Behaviours and Self-Care Practices of Podoconiosis Patients in North-West Ethiopia. (27536772)
2016
6
Measuring elimination of podoconiosis, endemicity classifications, case definition and targets: an international Delphi exercise. (26185194)
2015
7
Reasons for loss to follow-up of patients with podoconiosis in the Amhara Region, northern Ethiopia. (25576138)
2015
8
Depression and disability in people with podoconiosis: a comparative cross-sectional study in rural Northern Ethiopia. (26113669)
2015
9
The feasibility of eliminating podoconiosis. (26600613)
2015
10
Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. (26119541)
2015
11
Extent of podoconiosis-related stigma in Wolaita Zone, Southern Ethiopia: a cross-sectional study. (25485190)
2014
12
Modelling environmental factors correlated with podoconiosis: a geospatial study of non-filarial elephantiasis. (24946801)
2014
13
Histopathological and immunohistochemical features of nodular podoconiosis. (25401490)
2014
14
How 'The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks' has underpinned progress in podoconiosis research. (25059525)
2014
15
Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping. (25404069)
2014
16
Podoconiosis patients' willingness to pay for treatment services in Northwest Ethiopia: potential for cost recovery. (24642085)
2014
17
Integrated mapping of lymphatic filariasis and podoconiosis: lessons learnt from Ethiopia. (25164687)
2014
18
Mental distress and podoconiosis in Northern Ethiopia: a comparative cross-sectional study. (25062906)
2014
19
Ten years of podoconiosis research in Ethiopia. (24130908)
2013
20
Development of a scale to measure stigma related to podoconiosis in Southern Ethiopia. (23556435)
2013
21
Individual correlates of podoconiosis in areas of varying endemicity: a case-control study. (24340109)
2013
22
Spatial distribution of podoconiosis in relation to environmental factors in Ethiopia: a historical review. (23874587)
2013
23
Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss. (23445314)
2013
24
Podoconiosis in East and West Gojam Zones, northern Ethiopia. (22816005)
2012
25
The association of beliefs about heredity with preventive and interpersonal behaviors in communities affected by podoconiosis in rural Ethiopia. (22826482)
2012
26
Addressing the neglected tropical disease podoconiosis in Northern Ethiopia: lessons learned from a new community podoconiosis program. (22428078)
2012
27
Using a "genomics tool" to develop disease prevention strategy in a low-income setting: lessons from the podoconiosis research project. (22430163)
2012
28
Factors related to discontinued clinic attendance by patients with podoconiosis in southern Ethiopia: a qualitative study. (23095311)
2012
29
Launch of the international podoconiosis initiative. (22423883)
2012
30
Podoconiosis, a neglected tropical disease. (22744921)
2012
31
Parasitological, serological and clinical evidence for high prevalence of podoconiosis (non-filarial elephantiasis) in Midakegn district, central Ethiopia. (22487446)
2012
32
Burden of podoconiosis in poor rural communities in Gulliso woreda, West Ethiopia. (21666795)
2011
33
Images in clinical medicine. Podoconiosis. (21428762)
2011
34
Podoconiosis, non-filarial elephantiasis, and lymphology. (21446572)
2010
35
The role of transforming growth factor-beta1 and oxidative stress in podoconiosis pathogenesis. (20199540)
2010
36
Podoconiosis - non-filarial geochemical elephantiasis - a neglected tropical disease? (20096054)
2010
37
Health professionals' attitudes and misconceptions regarding podoconiosis: potential impact on integration of care in southern Ethiopia. (19717176)
2010
38
Assessment of respiratory function in patients with podoconiosis. (19046752)
2009
39
Impact of social stigma on the process of obtaining informed consent for genetic research on podoconiosis: a qualitative study. (19698115)
2009
40
Development and testing of a de novo clinical staging system for podoconiosis (endemic non-filarial elephantiasis). (18721188)
2008
41
Validation of the Dermatology Life Quality Index among patients with podoconiosis in southern Ethiopia. (18671781)
2008
42
Podoconiosis: a tropical model for gene-environment interactions? (16884751)
2007
43
Podoconiosis: non-infectious geochemical elephantiasis. (17976670)
2007
44
Podoconiosis: the most neglected tropical disease? (17368134)
2007
45
Prevalence of podoconiosis (endemic non-filarial elephantiasis) in Wolaitta, Southern Ethiopia. (14620426)
2003
46
Elephantiasis in Pawe settlement area: podoconiosis or bancroftian filariasis? (10214438)
1997
47
Podoconiosis in the Ethiopian Rift Valley. Role of beryllium and zirconium. (8236466)
1993
48
Podoconiosis (endemic non-filarial elephantiasis) in two resettlement schemes in western Ethiopia. (1641880)
1992
49
The significance of particle size of soils as a risk factor in the etiology of podoconiosis. (2096529)
1990
50
Non-filarial elephantiasis--confirmed as a geochemical disease, and renamed podoconiosis. (2843362)
1988

Variations for Podoconiosis

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Expression for genes affiliated with Podoconiosis

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Search GEO for disease gene expression data for Podoconiosis.

Pathways for genes affiliated with Podoconiosis

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Pathways related to Podoconiosis according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
2
Show member pathways
9.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
39.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
49.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
5
Show member pathways
9.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
69.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
79.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
8
Show member pathways
8.9HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, INSRR
98.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, MBL2
108.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, MBL2
11
Show member pathways
8.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
12
Show member pathways
8.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
138.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
14
Show member pathways
8.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
158.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
16
Show member pathways
8.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
17
Show member pathways
8.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
188.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, NEGR1, SDC1

GO Terms for genes affiliated with Podoconiosis

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Cellular components related to Podoconiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.2HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.2HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:00125079.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
4clathrin-coated endocytic vesicle membraneGO:00306699.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
5transport vesicle membraneGO:00306588.9HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
6trans-Golgi network membraneGO:00325888.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1, SLC24A5
7endocytic vesicle membraneGO:00306668.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
8Golgi membraneGO:00001398.7HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
9endosome membraneGO:00100088.4CD68, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2
10lysosomal membraneGO:00057658.1CD68, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1

Biological processes related to Podoconiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:00603339.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
2T cell receptor signaling pathwayGO:00508528.9HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
3immune responseGO:00069558.7HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2
4T cell costimulationGO:00312958.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
5antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198868.5HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1

Molecular functions related to Podoconiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.6HLA-DQA1, HLA-DQB1, HLA-DRB1
2MHC class II receptor activityGO:00323959.2HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2

Sources for Podoconiosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet