MCID: PDC001
MIFTS: 37

Podoconiosis malady

Categories: Immune diseases

Aliases & Classifications for Podoconiosis

Aliases & Descriptions for Podoconiosis:

Name: Podoconiosis 54 12 14 69
Podoconiosis, Susceptibility to 13

Classifications:



External Ids:

OMIM 54 614590
Disease Ontology 12 DOID:0050138

Summaries for Podoconiosis

OMIM : 54 Podoconiosis, or endemic nonfilarial elephantiasis, is a noninfectious geochemical disease characterized by edema of... (614590) more...

MalaCards based summary : Podoconiosis, also known as podoconiosis, susceptibility to, is related to elephantiasis and osteogenesis imperfecta congenita, microcephaly, and cataracts. An important gene associated with Podoconiosis is PDCOS (Podoconiosis, Susceptibility To), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. The drugs Glycerol and Petrolatum have been mentioned in the context of this disorder. Affiliated tissues include testes and skin, and related phenotype is integument.

Wikipedia : 71 Podoconiosis, also known as nonfilarial elephantiasis, is a disease of the lymph vessels of the lower... more...

Related Diseases for Podoconiosis

Diseases related to Podoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
id Related Disease Score Top Affiliating Genes
1 elephantiasis 10.3
2 osteogenesis imperfecta congenita, microcephaly, and cataracts 10.3 HLA-DQA1 HLA-DQB1
3 hodgkin's paragranuloma 10.2 HLA-DQB1 HLA-DQB2
4 apple allergy 10.2 HLA-DQB1 HLA-DRB1
5 immune deficiency, familial variable 10.2 HLA-DQB1 HLA-DRB1
6 lin-gettig syndrome 10.2 HLA-DQB1 HLA-DRB1
7 filarial elephantiasis 10.2
8 midline interhemispheric variant of holoprosencephaly 10.2 HLA-DQB1 HLA-DRB1
9 hemoglobin d disease 10.2 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 cervical adenoid basal carcinoma 10.2 HLA-DQA1 HLA-DQB1 HLA-DRB1
11 oromandibular dystonia 10.2 HLA-DQA1 HLA-DQB1 HLA-DRB1
12 bickerstaff brainstem encephalitis 10.2 HLA-DQA1 HLA-DQB1 HLA-DRB1
13 intrahepatic cholangiocarcinoma 10.1 HBA1 PDPN
14 anaerobic meningitis 10.1 HLA-DQB1 HLA-DQB2 HLA-DRB1
15 autosomal dominant intermediate charcot-marie-tooth 10.1 HLA-DQB1 HLA-DRB1
16 renal agenesis meningomyelocele mullerian defect 10.1 HLA-DQB1 HLA-DRB1
17 distal trisomy 14q 10.0 HLA-DQB1 HLA-DRB1 TGFB1
18 phencyclidine abuse 10.0 HBA1 PDPN
19 lymphangiectasia, intestinal 10.0 HLA-DQB1 HLA-DRB1 TGFB1
20 anthrax disease 10.0 CD68 HBA1
21 erythematosquamous dermatosis 10.0 HLA-DQB1 HLA-DRB1 TGFB1
22 lyme disease - neurological complications 10.0 HLA-DQB1 HLA-DRB1
23 peripheral artery disease 10.0 HLA-DQA1 HLA-DRB1 MBL2 TGFB1
24 hemopneumothorax 10.0 CD68 HBA1
25 parotid gland cancer 10.0 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1
26 bilateral parasagittal parieto-occipital polymicrogyria 10.0 HLA-DQA1 HLA-DQB1 HLA-DRB1 TGFB1
27 teeth hard tissue disease 9.9 CD68 HBA1
28 bilateral breast cancer 9.9 CD68 HBA1
29 lymphedema 9.9
30 filariasis 9.9
31 laryngeal adenoid cystic carcinoma 9.9 CD68 HBA1
32 diabetes mellitus, insulin-dependent, 20 9.9 HBA1 HLA-DQA1 HLA-DQB1 HLA-DQB2 HLA-DRB1
33 mesenteric vascular occlusion 9.8 CD68 HBA1 PDPN
34 onchocerciasis 9.8
35 squamous blepharitis 9.6 CD68 HBA1 PDPN SDC1
36 ragweed sensitivity 7.9 CD68 CDKAL1 HBA1 HLA-DQA1 HLA-DQA2 HLA-DQB1

Graphical network of the top 20 diseases related to Podoconiosis:



Diseases related to Podoconiosis

Symptoms & Phenotypes for Podoconiosis

Clinical features from OMIM:

614590

MGI Mouse Phenotypes related to Podoconiosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.23 CDKAL1 PAH PDPN PPARA RUNX1T1 SDC1

Drugs & Therapeutics for Podoconiosis

Drugs for Podoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Experimental Phase 3 56-81-5 753
2
Petrolatum Approved Phase 3 8009-03-8
3 Sodium hypochlorite Phase 3
4 Disinfectants Phase 3
5 Eusol Phase 3
6 Anti-Infective Agents Phase 3
7 Protective Agents Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
2 Promoting Consistent Shoe Use Among Children At High Risk for Podoconiosis Completed NCT01160523
3 Genetic and Other Aspects of Podoconiosis Not yet recruiting NCT01939431

Search NIH Clinical Center for Podoconiosis

Genetic Tests for Podoconiosis

Anatomical Context for Podoconiosis

MalaCards organs/tissues related to Podoconiosis:

39
Testes, Skin

Publications for Podoconiosis

Articles related to Podoconiosis:

(show top 50) (show all 77)
id Title Authors Year
1
Willingness to pay for footwear, and associated factors related to podoconiosis in northern Ethiopia. ( 27620919 )
2016
2
Detecting and staging podoconiosis cases in North West Cameroon: positive predictive value of clinical screening of patients by community health workers and researchers. ( 27650390 )
2016
3
Podoconiosis in Rural Tanzania. ( 27385665 )
2016
4
Using Qualitative Methods to Explore Lay Explanatory Models, Health-Seeking Behaviours and Self-Care Practices of Podoconiosis Patients in North-West Ethiopia. ( 27536772 )
2016
5
Burden assessment of podoconiosis in Wayu Tuka woreda, east Wollega zone, western Ethiopia: a community-based cross-sectional study. ( 27670520 )
2016
6
Dual Perspectives On Stigma: Reports of Experienced and Enacted Stigma by Those Affected and Unaffected by Podoconiosis. ( 27747202 )
2016
7
Association Between Causal Beliefs and Shoe Wearing to Prevent Podoconiosis: A Baseline Study. ( 26928843 )
2016
8
Preparing for and Executing a Randomised Controlled Trial of Podoconiosis Treatment in Northern Ethiopia: The Utility of Rapid Ethical Assessment. ( 26967654 )
2016
9
Reasons for loss to follow-up of patients with podoconiosis in the Amhara Region, northern Ethiopia. ( 25576138 )
2015
10
Mapping and Modelling the Geographical Distribution and Environmental Limits of Podoconiosis in Ethiopia. ( 26222887 )
2015
11
The feasibility of eliminating podoconiosis. ( 26600613 )
2015
12
Depression and disability in people with podoconiosis: a comparative cross-sectional study in rural Northern Ethiopia. ( 26113669 )
2015
13
Podoconiosis treatment in northern Ethiopia (GoLBet): study protocol for a randomised controlled trial. ( 26177812 )
2015
14
Measuring elimination of podoconiosis, endemicity classifications, case definition and targets: an international Delphi exercise. ( 26185194 )
2015
15
Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. ( 26119541 )
2015
16
Podoconiosis patients' willingness to pay for treatment services in Northwest Ethiopia: potential for cost recovery. ( 24642085 )
2014
17
How 'The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks' has underpinned progress in podoconiosis research. ( 25059525 )
2014
18
Mental distress and podoconiosis in Northern Ethiopia: a comparative cross-sectional study. ( 25062906 )
2014
19
How soil scientists help combat podoconiosis, a neglected tropical disease. ( 24828083 )
2014
20
Modelling environmental factors correlated with podoconiosis: a geospatial study of non-filarial elephantiasis. ( 24946801 )
2014
21
Histopathological and immunohistochemical features of nodular podoconiosis. ( 25401490 )
2014
22
Barriers to access and re-attendance for treatment of podoconiosis: a qualitative study in northern Ethiopia. ( 25540135 )
2014
23
Extent of podoconiosis-related stigma in Wolaita Zone, Southern Ethiopia: a cross-sectional study. ( 25485190 )
2014
24
Integrated mapping of lymphatic filariasis and podoconiosis: lessons learnt from Ethiopia. ( 25164687 )
2014
25
Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping. ( 25404069 )
2014
26
Individual correlates of podoconiosis in areas of varying endemicity: a case-control study. ( 24340109 )
2013
27
Spatial distribution of podoconiosis in relation to environmental factors in Ethiopia: a historical review. ( 23874587 )
2013
28
Stigma towards a Neglected Tropical Disease: Felt and enacted Stigma Scores among Podoconiosis Patients in Northern Ethiopia. ( 24330684 )
2013
29
Occupational podoconiosis. ( 24772719 )
2013
30
Ten years of podoconiosis research in Ethiopia. ( 24130908 )
2013
31
Community-based survey of podoconiosis in Bedele Zuria woreda, west Ethiopia. ( 24030111 )
2013
32
The impact of podoconiosis on quality of life in Northern Ethiopia. ( 23866905 )
2013
33
Podoconiosis and soil-transmitted helminths (STHs): double burden of neglected tropical diseases in Wolaita zone, rural Southern Ethiopia. ( 23516659 )
2013
34
Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss. ( 23445314 )
2013
35
Development of a scale to measure stigma related to podoconiosis in Southern Ethiopia. ( 23556435 )
2013
36
Podoconiosis in East and West Gojam Zones, northern Ethiopia. ( 22816005 )
2012
37
Patients' perceptions of podoconiosis causes, prevention and consequences in East and West Gojam, Northern Ethiopia. ( 23020758 )
2012
38
Addressing the neglected tropical disease podoconiosis in Northern Ethiopia: lessons learned from a new community podoconiosis program. ( 22428078 )
2012
39
Podoconiosis, a neglected tropical disease. ( 22744921 )
2012
40
Parasitological, serological and clinical evidence for high prevalence of podoconiosis (non-filarial elephantiasis) in Midakegn district, central Ethiopia. ( 22487446 )
2012
41
The association of beliefs about heredity with preventive and interpersonal behaviors in communities affected by podoconiosis in rural Ethiopia. ( 22826482 )
2012
42
Launch of the international podoconiosis initiative. ( 22423883 )
2012
43
Podoconiosis: the forgotten tropical lymphedema. ( 23008936 )
2012
44
Using a "genomics tool" to develop disease prevention strategy in a low-income setting: lessons from the podoconiosis research project. ( 22430163 )
2012
45
Factors related to discontinued clinic attendance by patients with podoconiosis in southern Ethiopia: a qualitative study. ( 23095311 )
2012
46
HLA class II locus and susceptibility to podoconiosis. ( 22455414 )
2012
47
Podoconiosis: an experience from Tigray, Northern Ethiopia. ( 21679822 )
2011
48
Images in clinical medicine. Podoconiosis. ( 21428762 )
2011
49
A qualitative study on stigma and coping strategies of patients with podoconiosis in Wolaita zone, Southern Ethiopia. ( 24038367 )
2011
50
Burden of podoconiosis in poor rural communities in Gulliso woreda, West Ethiopia. ( 21666795 )
2011

Variations for Podoconiosis

Expression for Podoconiosis

Search GEO for disease gene expression data for Podoconiosis.

Pathways for Podoconiosis

Pathways related to Podoconiosis according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1 TGFB1
2
Show member pathways
12.53 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
3
Show member pathways
12.45 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
4
Show member pathways
12.45 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1 TGFB1
5 12.35 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1 TGFB1
6
Show member pathways
12.27 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1
7
Show member pathways
12.27 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
8 12.19 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1
9
Show member pathways
12.18 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1 TGFB1
10 12.11 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1 TGFB1
11
Show member pathways
12.04 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
12 11.95 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1 MBL2
13
Show member pathways
11.85 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
14 11.82 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1
15
Show member pathways
11.76 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
16 11.67 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
17 11.63 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1
18 11.59 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1 NEGR1 SDC1
19 11.51 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1 TGFB1
20 11.43 HBA1 SDC1 TGFB1
21 10.84 SDC1 TGFB1
22 10.77 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRB1 MBL2

GO Terms for Podoconiosis

Cellular components related to Podoconiosis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 lysosomal membrane GO:0005765 9.93 CD68 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
2 Golgi membrane GO:0000139 9.91 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
3 endosome membrane GO:0010008 9.91 CD68 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
4 endosome GO:0005768 9.89 CD68 HLA-DQA1 HLA-DQA2 HLA-DQB2 HLA-DRB1
5 lysosome GO:0005764 9.83 HLA-DQA1 HLA-DQA2 HLA-DQB2 HLA-DRB1
6 endocytic vesicle membrane GO:0030666 9.8 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
7 external side of plasma membrane GO:0009897 9.78 HLA-DQB2 HLA-DRB1 PDPN SDC1
8 ER to Golgi transport vesicle membrane GO:0012507 9.77 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
9 transport vesicle membrane GO:0030658 9.72 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
10 clathrin-coated endocytic vesicle membrane GO:0030669 9.65 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
11 trans-Golgi network membrane GO:0032588 9.63 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1 SLC24A5
12 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.35 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
13 MHC class II protein complex GO:0042613 9.02 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1

Biological processes related to Podoconiosis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.88 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
2 immune system process GO:0002376 9.85 HLA-DQA1 HLA-DQA2 HLA-DQB2 HLA-DRB1 MBL2
3 T cell receptor signaling pathway GO:0050852 9.77 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
4 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.72 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
5 wound healing GO:0042060 9.67 PPARA SDC1 TGFB1
6 T cell costimulation GO:0031295 9.65 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
7 interferon-gamma-mediated signaling pathway GO:0060333 9.55 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
8 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.43 HLA-DQB1 HLA-DRB1
9 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.4 HLA-DQB1 HLA-DRB1
10 antigen processing and presentation GO:0019882 9.35 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1
11 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.02 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1

Molecular functions related to Podoconiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.26 HLA-DQA1 HLA-DQB1 HLA-DQB2 HLA-DRB1
2 MHC class II receptor activity GO:0032395 9.02 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRB1

Sources for Podoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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