Aliases & Classifications for Podoconiosis

MalaCards integrated aliases for Podoconiosis:

Name: Podoconiosis 54 12 14 69
Podoconiosis, Susceptibility to 13

Classifications:



External Ids:

OMIM 54 614590
Disease Ontology 12 DOID:0050138

Summaries for Podoconiosis

OMIM : 54
Podoconiosis, or endemic nonfilarial elephantiasis, is a noninfectious geochemical disease characterized by edema of the foot and lower leg that progresses to severe elephantiasis. It is a chronic and debilitating disorder that is a public health problem in at least 10 countries in tropical Africa, Central America, and northern India. Podoconiosis occurs among subsistence farmers and other occupational groups whose feet are exposed over many years to red clay soil derived from alkalic volcanic rock. However, podoconiosis develops only in a subgroup of exposed people, and studies have shown familial clustering with high heritability (summary by Davey et al. (2007) and Tekola Ayele et al. (2012)). (614590)

MalaCards based summary : Podoconiosis, also known as podoconiosis, susceptibility to, is related to elephantiasis and filarial elephantiasis. An important gene associated with Podoconiosis is PDCOS (Podoconiosis, Susceptibility To), and among its related pathways/superpathways is Cell adhesion molecules (CAMs). The drugs Glycerol and Petrolatum have been mentioned in the context of this disorder. Affiliated tissues include skin and testes.

Wikipedia : 72 Podoconiosis, also known as nonfilarial elephantiasis, is a disease of the lymph vessels of the lower... more...

Related Diseases for Podoconiosis

Diseases related to Podoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 elephantiasis 10.3
2 filarial elephantiasis 10.2
3 filariasis 10.0
4 lymphedema 9.9
5 cataract 9.7
6 onchocerciasis 9.7
7 autoinflammation, lipodystrophy, and dermatosis syndrome 7.9 HLA-DQA1 INSRR NEGR1 PDCOS SLC24A5

Graphical network of the top 20 diseases related to Podoconiosis:



Diseases related to Podoconiosis

Symptoms & Phenotypes for Podoconiosis

Clinical features from OMIM:

614590

Drugs & Therapeutics for Podoconiosis

Drugs for Podoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Investigational Phase 3 56-81-5 753
2
Petrolatum Approved Phase 3 8009-03-8
3 Anti-Infective Agents Phase 3
4 Disinfectants Phase 3
5 Eusol Phase 3
6 Protective Agents Phase 3
7 Sodium hypochlorite Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
2 Promoting Consistent Shoe Use Among Children At High Risk for Podoconiosis Completed NCT01160523
3 Genetic and Other Aspects of Podoconiosis Not yet recruiting NCT01939431

Search NIH Clinical Center for Podoconiosis

Genetic Tests for Podoconiosis

Anatomical Context for Podoconiosis

MalaCards organs/tissues related to Podoconiosis:

39
Skin, Testes

Publications for Podoconiosis

Articles related to Podoconiosis:

(show top 50) (show all 88)
id Title Authors Year
1
The global atlas of podoconiosis. ( 28395836 )
2017
2
Surgical nodulectomies can heal in patients with lymphoedema secondary to podoconiosis in resource-poor settings. ( 28256715 )
2017
3
Soil iron and aluminium concentrations and feet hygiene as possible predictors of Podoconiosis occurrence in Kenya. ( 28832604 )
2017
4
A Randomised Controlled Trial to evaluate the effect of a new skin care regimen on skin barrier function in those with podoconiosis in Ethiopia. ( 28374907 )
2017
5
Health beliefs of school-age rural children in podoconiosis-affected families: A qualitative study in Southern Ethiopia. ( 28542227 )
2017
6
Podoconiosis, trachomatous trichiasis and cataract in northern Ethiopia: A comparative cross sectional study. ( 28187129 )
2017
7
Podoconiosis in Ethiopia: From Neglect to Priority Public Health Problem. ( 28878431 )
2017
8
Integrated morbidity management for lymphatic filariasis and podoconiosis, Ethiopia. ( 28867846 )
2017
9
Risk Factors for Podoconiosis: Kamwenge District, Western Uganda, September 2015. ( 28719274 )
2017
10
Haemolytic activity of soil from areas of varying podoconiosis endemicity in Ethiopia. ( 28493920 )
2017
11
Podoconiosis Is the Diagnosis. ( 28632875 )
2017
12
Podoconiosis in Rural Tanzania. ( 27385665 )
2016
13
Willingness to pay for footwear, and associated factors related to podoconiosis in northern Ethiopia. ( 27620919 )
2016
14
Dual Perspectives On Stigma: Reports of Experienced and Enacted Stigma by Those Affected and Unaffected by Podoconiosis. ( 27747202 )
2016
15
Burden assessment of podoconiosis in Wayu Tuka woreda, east Wollega zone, western Ethiopia: a community-based cross-sectional study. ( 27670520 )
2016
16
Association Between Causal Beliefs and Shoe Wearing to Prevent Podoconiosis: A Baseline Study. ( 26928843 )
2016
17
Using Qualitative Methods to Explore Lay Explanatory Models, Health-Seeking Behaviours and Self-Care Practices of Podoconiosis Patients in North-West Ethiopia. ( 27536772 )
2016
18
Detecting and staging podoconiosis cases in North West Cameroon: positive predictive value of clinical screening of patients by community health workers and researchers. ( 27650390 )
2016
19
Preparing for and Executing a Randomised Controlled Trial of Podoconiosis Treatment in Northern Ethiopia: The Utility of Rapid Ethical Assessment. ( 26967654 )
2016
20
Depression and disability in people with podoconiosis: a comparative cross-sectional study in rural Northern Ethiopia. ( 26113669 )
2015
21
The feasibility of eliminating podoconiosis. ( 26600613 )
2015
22
Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. ( 26119541 )
2015
23
Reasons for loss to follow-up of patients with podoconiosis in the Amhara Region, northern Ethiopia. ( 25576138 )
2015
24
Mapping and Modelling the Geographical Distribution and Environmental Limits of Podoconiosis in Ethiopia. ( 26222887 )
2015
25
Measuring elimination of podoconiosis, endemicity classifications, case definition and targets: an international Delphi exercise. ( 26185194 )
2015
26
Podoconiosis treatment in northern Ethiopia (GoLBet): study protocol for a randomised controlled trial. ( 26177812 )
2015
27
Integrated mapping of lymphatic filariasis and podoconiosis: lessons learnt from Ethiopia. ( 25164687 )
2014
28
Mental distress and podoconiosis in Northern Ethiopia: a comparative cross-sectional study. ( 25062906 )
2014
29
Barriers to access and re-attendance for treatment of podoconiosis: a qualitative study in northern Ethiopia. ( 25540135 )
2014
30
Extent of podoconiosis-related stigma in Wolaita Zone, Southern Ethiopia: a cross-sectional study. ( 25485190 )
2014
31
How 'The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks' has underpinned progress in podoconiosis research. ( 25059525 )
2014
32
Podoconiosis patients' willingness to pay for treatment services in Northwest Ethiopia: potential for cost recovery. ( 24642085 )
2014
33
Histopathological and immunohistochemical features of nodular podoconiosis. ( 25401490 )
2014
34
Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping. ( 25404069 )
2014
35
Modelling environmental factors correlated with podoconiosis: a geospatial study of non-filarial elephantiasis. ( 24946801 )
2014
36
How soil scientists help combat podoconiosis, a neglected tropical disease. ( 24828083 )
2014
37
Ten years of podoconiosis research in Ethiopia. ( 24130908 )
2013
38
Occupational podoconiosis. ( 24772719 )
2013
39
Spatial distribution of podoconiosis in relation to environmental factors in Ethiopia: a historical review. ( 23874587 )
2013
40
Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss. ( 23445314 )
2013
41
Individual correlates of podoconiosis in areas of varying endemicity: a case-control study. ( 24340109 )
2013
42
The impact of podoconiosis on quality of life in Northern Ethiopia. ( 23866905 )
2013
43
Podoconiosis and soil-transmitted helminths (STHs): double burden of neglected tropical diseases in Wolaita zone, rural Southern Ethiopia. ( 23516659 )
2013
44
Stigma towards a Neglected Tropical Disease: Felt and enacted Stigma Scores among Podoconiosis Patients in Northern Ethiopia. ( 24330684 )
2013
45
Development of a scale to measure stigma related to podoconiosis in Southern Ethiopia. ( 23556435 )
2013
46
Community-based survey of podoconiosis in Bedele Zuria woreda, west Ethiopia. ( 24030111 )
2013
47
Podoconiosis: the forgotten tropical lymphedema. ( 23008936 )
2012
48
Using a "genomics tool" to develop disease prevention strategy in a low-income setting: lessons from the podoconiosis research project. ( 22430163 )
2012
49
Addressing the neglected tropical disease podoconiosis in Northern Ethiopia: lessons learned from a new community podoconiosis program. ( 22428078 )
2012
50
Parasitological, serological and clinical evidence for high prevalence of podoconiosis (non-filarial elephantiasis) in Midakegn district, central Ethiopia. ( 22487446 )
2012

Variations for Podoconiosis

Expression for Podoconiosis

Search GEO for disease gene expression data for Podoconiosis.

Pathways for Podoconiosis

Pathways related to Podoconiosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.78 HLA-DQA1 NEGR1

GO Terms for Podoconiosis

Cellular components related to Podoconiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.13 HLA-DQA1 INSRR SLC24A5
2 trans-Golgi network membrane GO:0032588 8.62 HLA-DQA1 SLC24A5

Sources for Podoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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