MCID: PDC001
MIFTS: 37

Podoconiosis malady

Category: Immune diseases

Aliases & Classifications for Podoconiosis

About this section

Aliases & Descriptions for Podoconiosis:

Name: Podoconiosis 52 11 13 68
 
Podoconiosis, Susceptibility to 12

Classifications:



External Ids:

OMIM52 614590
Disease Ontology11 DOID:0050138

Summaries for Podoconiosis

About this section
OMIM:52 Podoconiosis, or endemic nonfilarial elephantiasis, is a noninfectious geochemical disease characterized by edema of... (614590) more...

MalaCards based summary: Podoconiosis, also known as podoconiosis, susceptibility to, is related to elephantiasis and osteogenesis imperfecta congenita, microcephaly, and cataracts. An important gene associated with Podoconiosis is PDCOS (Podoconiosis, Susceptibility To), and among its related pathways are Syndecan-1-mediated signaling events and CTLA4 Signaling. Affiliated tissues include testes and skin, and related mouse phenotype integument.

Wikipedia:71 Podoconiosis, also known as nonfilarial elephantiasis, is a disease of the lymph vessels of the lower... more...

Related Diseases for Podoconiosis

About this section

Diseases related to Podoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
idRelated DiseaseScoreTop Affiliating Genes
1elephantiasis10.3
2osteogenesis imperfecta congenita, microcephaly, and cataracts10.3HLA-DQA1, HLA-DQB1
3hodgkin's paragranuloma10.2HLA-DQB1, HLA-DQB2
4apple allergy10.2HLA-DQB1, HLA-DRB1
5immune deficiency, familial variable10.2HLA-DQB1, HLA-DRB1
6lin-gettig syndrome10.2HLA-DQB1, HLA-DRB1
7filarial elephantiasis10.2
8midline interhemispheric variant of holoprosencephaly10.2HLA-DQB1, HLA-DRB1
9hemoglobin d disease10.2HLA-DQA1, HLA-DQB1, HLA-DRB1
10cervical adenoid basal carcinoma10.2HLA-DQA1, HLA-DQB1, HLA-DRB1
11oromandibular dystonia10.2HLA-DQA1, HLA-DQB1, HLA-DRB1
12bickerstaff brainstem encephalitis10.2HLA-DQA1, HLA-DQB1, HLA-DRB1
13intrahepatic cholangiocarcinoma10.1HBA1, PDPN
14anaerobic meningitis10.1HLA-DQB1, HLA-DQB2, HLA-DRB1
15autosomal dominant intermediate charcot-marie-tooth10.1HLA-DQB1, HLA-DRB1
16renal agenesis meningomyelocele mullerian defect10.1HLA-DQB1, HLA-DRB1
17distal trisomy 14q10.0HLA-DQB1, HLA-DRB1, TGFB1
18phencyclidine abuse10.0HBA1, PDPN
19lymphangiectasia, intestinal10.0HLA-DQB1, HLA-DRB1, TGFB1
20anthrax disease10.0CD68, HBA1
21erythematosquamous dermatosis10.0HLA-DQB1, HLA-DRB1, TGFB1
22lyme disease - neurological complications10.0HLA-DQB1, HLA-DRB1
23peripheral artery disease10.0HLA-DQA1, HLA-DRB1, MBL2, TGFB1
24hemopneumothorax10.0CD68, HBA1
25parotid gland cancer10.0HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
26bilateral parasagittal parieto-occipital polymicrogyria10.0HLA-DQA1, HLA-DQB1, HLA-DRB1, TGFB1
27teeth hard tissue disease9.9CD68, HBA1
28bilateral breast cancer9.9CD68, HBA1
29lymphedema9.9
30filariasis9.9
31laryngeal adenoid cystic carcinoma9.9CD68, HBA1
32diabetes mellitus, insulin-dependent, 209.9HBA1, HLA-DQA1, HLA-DQB1, HLA-DQB2, HLA-DRB1
33mesenteric vascular occlusion9.8CD68, HBA1, PDPN
34onchocerciasis9.8
35squamous blepharitis9.6CD68, HBA1, PDPN, SDC1
36ragweed sensitivity7.9CD68, CDKAL1, HBA1, HLA-DQA1, HLA-DQA2, HLA-DQB1

Graphical network of the top 20 diseases related to Podoconiosis:



Diseases related to podoconiosis

Symptoms & Phenotypes for Podoconiosis

About this section


Clinical features from OMIM:

614590

MGI Mouse Phenotypes related to Podoconiosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.2CDKAL1, PAH, PDPN, PPARA, RUNX1T1, SDC1

Drugs & Therapeutics for Podoconiosis

About this section

Drugs for Podoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PetrolatumapprovedPhase 3938009-03-8
Synonyms:
Multi-hydrocarbon
Paraffinum album
Paraffinum flavum
Petrolatum base
Petrolatum, white
 
Petrolatum,amber
Petrolatum,white
Petroleum jelly
Soft paraffin
White petrolatum
White, soft paraffin
Yellow soft paraffin
2
Glycerolexperimental, approvedPhase 323856-81-5753
Synonyms:
1,2,3-Trihydroxypropane
1,2,3-propanetriol
1,2,3-trihydroxypropane
Bulbold
Cristal
E 422
Emery 916
Glyceol Opthalgan
Glycerin
Glycerin, anhydrous
Glycerin,anhydrous
Glycerine
Glycerinum
 
Glyceritol
Glycerol
Glycyl alcohol
Glyrol
Glysanin
IFP
Incorporation factor
Mackstat H 66
Monoctanoin component D
Osmoglyn
Pricerine 9091
Propanetriol
RG-S
Trihydroxypropane
Tryhydroxypropane
3Sodium hypochloritePhase 348
4Protective AgentsPhase 37443
5DisinfectantsPhase 3582
6Anti-Infective AgentsPhase 322062
7EusolPhase 348

Interventional clinical trials:

idNameStatusNCT IDPhase
1An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With PodoconiosisCompletedNCT02839772Phase 3
2Promoting Consistent Shoe Use Among Children At High Risk for PodoconiosisCompletedNCT01160523
3Genetic and Other Aspects of PodoconiosisNot yet recruitingNCT01939431

Search NIH Clinical Center for Podoconiosis

Genetic Tests for Podoconiosis

About this section

Anatomical Context for Podoconiosis

About this section

MalaCards organs/tissues related to Podoconiosis:

36
Testes, Skin

Publications for Podoconiosis

About this section

Articles related to Podoconiosis:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Willingness to pay for footwear, and associated factors related to podoconiosis in northern Ethiopia. (27620919)
2016
2
Detecting and staging podoconiosis cases in North West Cameroon: positive predictive value of clinical screening of patients by community health workers and researchers. (27650390)
2016
3
Podoconiosis in Rural Tanzania. (27385665)
2016
4
Using Qualitative Methods to Explore Lay Explanatory Models, Health-Seeking Behaviours and Self-Care Practices of Podoconiosis Patients in North-West Ethiopia. (27536772)
2016
5
Burden assessment of podoconiosis in Wayu Tuka woreda, east Wollega zone, western Ethiopia: a community-based cross-sectional study. (27670520)
2016
6
Dual Perspectives On Stigma: Reports of Experienced and Enacted Stigma by Those Affected and Unaffected by Podoconiosis. (27747202)
2016
7
Association Between Causal Beliefs and Shoe Wearing to Prevent Podoconiosis: A Baseline Study. (26928843)
2016
8
Preparing for and Executing a Randomised Controlled Trial of Podoconiosis Treatment in Northern Ethiopia: The Utility of Rapid Ethical Assessment. (26967654)
2016
9
Reasons for loss to follow-up of patients with podoconiosis in the Amhara Region, northern Ethiopia. (25576138)
2015
10
Mapping and Modelling the Geographical Distribution and Environmental Limits of Podoconiosis in Ethiopia. (26222887)
2015
11
The feasibility of eliminating podoconiosis. (26600613)
2015
12
Depression and disability in people with podoconiosis: a comparative cross-sectional study in rural Northern Ethiopia. (26113669)
2015
13
Podoconiosis treatment in northern Ethiopia (GoLBet): study protocol for a randomised controlled trial. (26177812)
2015
14
Measuring elimination of podoconiosis, endemicity classifications, case definition and targets: an international Delphi exercise. (26185194)
2015
15
Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. (26119541)
2015
16
Podoconiosis patients' willingness to pay for treatment services in Northwest Ethiopia: potential for cost recovery. (24642085)
2014
17
How 'The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks' has underpinned progress in podoconiosis research. (25059525)
2014
18
Mental distress and podoconiosis in Northern Ethiopia: a comparative cross-sectional study. (25062906)
2014
19
How soil scientists help combat podoconiosis, a neglected tropical disease. (24828083)
2014
20
Modelling environmental factors correlated with podoconiosis: a geospatial study of non-filarial elephantiasis. (24946801)
2014
21
Histopathological and immunohistochemical features of nodular podoconiosis. (25401490)
2014
22
Barriers to access and re-attendance for treatment of podoconiosis: a qualitative study in northern Ethiopia. (25540135)
2014
23
Extent of podoconiosis-related stigma in Wolaita Zone, Southern Ethiopia: a cross-sectional study. (25485190)
2014
24
Integrated mapping of lymphatic filariasis and podoconiosis: lessons learnt from Ethiopia. (25164687)
2014
25
Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping. (25404069)
2014
26
Individual correlates of podoconiosis in areas of varying endemicity: a case-control study. (24340109)
2013
27
Spatial distribution of podoconiosis in relation to environmental factors in Ethiopia: a historical review. (23874587)
2013
28
Stigma towards a Neglected Tropical Disease: Felt and enacted Stigma Scores among Podoconiosis Patients in Northern Ethiopia. (24330684)
2013
29
Occupational podoconiosis. (24772719)
2013
30
Ten years of podoconiosis research in Ethiopia. (24130908)
2013
31
Community-based survey of podoconiosis in Bedele Zuria woreda, west Ethiopia. (24030111)
2013
32
The impact of podoconiosis on quality of life in Northern Ethiopia. (23866905)
2013
33
Podoconiosis and soil-transmitted helminths (STHs): double burden of neglected tropical diseases in Wolaita zone, rural Southern Ethiopia. (23516659)
2013
34
Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss. (23445314)
2013
35
Development of a scale to measure stigma related to podoconiosis in Southern Ethiopia. (23556435)
2013
36
Podoconiosis in East and West Gojam Zones, northern Ethiopia. (22816005)
2012
37
Patients' perceptions of podoconiosis causes, prevention and consequences in East and West Gojam, Northern Ethiopia. (23020758)
2012
38
Addressing the neglected tropical disease podoconiosis in Northern Ethiopia: lessons learned from a new community podoconiosis program. (22428078)
2012
39
Podoconiosis, a neglected tropical disease. (22744921)
2012
40
Parasitological, serological and clinical evidence for high prevalence of podoconiosis (non-filarial elephantiasis) in Midakegn district, central Ethiopia. (22487446)
2012
41
The association of beliefs about heredity with preventive and interpersonal behaviors in communities affected by podoconiosis in rural Ethiopia. (22826482)
2012
42
Launch of the international podoconiosis initiative. (22423883)
2012
43
Podoconiosis: the forgotten tropical lymphedema. (23008936)
2012
44
Using a "genomics tool" to develop disease prevention strategy in a low-income setting: lessons from the podoconiosis research project. (22430163)
2012
45
Factors related to discontinued clinic attendance by patients with podoconiosis in southern Ethiopia: a qualitative study. (23095311)
2012
46
HLA class II locus and susceptibility to podoconiosis. (22455414)
2012
47
Podoconiosis: an experience from Tigray, Northern Ethiopia. (21679822)
2011
48
Images in clinical medicine. Podoconiosis. (21428762)
2011
49
A qualitative study on stigma and coping strategies of patients with podoconiosis in Wolaita zone, Southern Ethiopia. (24038367)
2011
50
Burden of podoconiosis in poor rural communities in Gulliso woreda, West Ethiopia. (21666795)
2011

Variations for Podoconiosis

About this section

Expression for genes affiliated with Podoconiosis

About this section
Search GEO for disease gene expression data for Podoconiosis.

Pathways for genes affiliated with Podoconiosis

About this section

Pathways related to Podoconiosis according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
19.2SDC1, TGFB1
29.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
39.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
4
Show member pathways
9.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
59.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
68.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, MBL2
78.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, MBL2
88.8HBA1, SDC1, TGFB1
9
Show member pathways
8.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
10
Show member pathways
8.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
11
Show member pathways
8.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
12
Show member pathways
8.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
138.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
14
Show member pathways
8.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
15
Show member pathways
8.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
16
Show member pathways
8.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, TGFB1
178.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, TGFB1
188.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, TGFB1
19
Show member pathways
8.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, TGFB1
208.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, TGFB1
21
Show member pathways
8.3HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1, TGFB1
228.0HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, NEGR1, SDC1

GO Terms for genes affiliated with Podoconiosis

About this section

Cellular components related to Podoconiosis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:00057649.7HLA-DQA1, HLA-DQA2, HLA-DQB2, HLA-DRB1
2clathrin-coated endocytic vesicle membraneGO:00306699.5HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
3endocytic vesicle membraneGO:00306669.5HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
4ER to Golgi transport vesicle membraneGO:00125079.5HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
5Golgi membraneGO:00001399.5HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
6integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.5HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
7MHC class II protein complexGO:00426139.3HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
8endosomeGO:00057689.3CD68, HLA-DQA1, HLA-DQA2, HLA-DQB2, HLA-DRB1
9external side of plasma membraneGO:00098979.1HLA-DQB2, HLA-DRB1, PDPN, SDC1
10trans-Golgi network membraneGO:00325889.0HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1, SLC24A5
11endosome membraneGO:00100089.0CD68, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
12lysosomal membraneGO:00057658.9CD68, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
13transport vesicle membraneGO:00306588.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1

Biological processes related to Podoconiosis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1humoral immune response mediated by circulating immunoglobulinGO:000245510.5HLA-DQB1, HLA-DRB1
2immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.4HLA-DQB1, HLA-DRB1
3antigen processing and presentationGO:00198829.5HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
4antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.5HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
5antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.5HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
6immune responseGO:00069559.5HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
7immune system processGO:00023769.5HLA-DQA1, HLA-DQA2, HLA-DQB2, HLA-DRB1, MBL2
8interferon-gamma-mediated signaling pathwayGO:00603339.4HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
9T cell costimulationGO:00312959.4HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
10T cell receptor signaling pathwayGO:00508529.3HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
11wound healingGO:00420608.8PPARA, SDC1, TGFB1

Molecular functions related to Podoconiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.3HLA-DQA1, HLA-DQB1, HLA-DQB2, HLA-DRB1
2MHC class II receptor activityGO:00323959.2HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1

Sources for Podoconiosis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet