MCID: PDC001
MIFTS: 36

Podoconiosis malady

Category: Immune diseases

Aliases & Classifications for Podoconiosis

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Aliases & Descriptions for Podoconiosis:

Name: Podoconiosis 52 11 13 68
 
Podoconiosis, Susceptibility to 12

Classifications:



External Ids:

OMIM52 614590
Disease Ontology11 DOID:0050138

Summaries for Podoconiosis

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OMIM:52 Podoconiosis, or endemic nonfilarial elephantiasis, is a noninfectious geochemical disease characterized by edema of... (614590) more...

MalaCards based summary: Podoconiosis, also known as podoconiosis, susceptibility to, is related to osteogenesis imperfecta congenita, microcephaly, and cataracts and fruit allergy. An important gene associated with Podoconiosis is PDCOS (Podoconiosis, Susceptibility To), and among its related pathways are Tuberculosis and Toxoplasmosis. Affiliated tissues include skin and testes, and related mouse phenotype integument.

Wikipedia:71 Podoconiosis, also known as nonfilarial elephantiasis, is a disease of the lymph vessels of the lower... more...

Related Diseases for Podoconiosis

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Diseases related to Podoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1osteogenesis imperfecta congenita, microcephaly, and cataracts10.6HLA-DQA1, HLA-DQB1
2fruit allergy10.5HLA-DQB1, HLA-DRB1
3panuveitis10.5HLA-DQA1, HLA-DRB1
4quinquaud's decalvans folliculitis10.5HLA-DQB1, HLA-DRB1
5pediatric systemic lupus erythematosus10.5HLA-DQB1, HLA-DRB1
6vitreoretinochoroidopathy dominant10.5HLA-DQB1, HLA-DRB1
7krieble bixler syndrome10.4HLA-DQB1, HLA-DRB1
8spondylarthropathy10.4HLA-DQB1, HLA-DRB1
9mitochondrial encephalomyopathy10.4HLA-DQB1, HLA-DRB1
10rheumatic myocarditis10.4HLA-DQB1, HLA-DRB1
11nebulin-related early-onset distal myopathy10.4HLA-DQB1, HLA-DRB1
12purpura fulminans10.4HLA-DQB1, HLA-DRB1
13lymphocytic colitis10.4HLA-DQB1, HLA-DRB1
14peripheral t-cell lymphoma10.4HLA-DQB1, HLA-DRB1
15thrombocytopenia due to platelet alloimmunization10.4HLA-DQB1, HLA-DRB1
16orbit alveolar rhabdomyosarcoma10.4HLA-DQB1, HLA-DRB1
17wolffian duct adenocarcinoma10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
18parsonage turner syndrome10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
19lipodermatosclerosis10.3HLA-DQB1, HLA-DRB1
20myopathy-growth delay-intellectual disability-hypospadias syndrome10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
21renovascular hypertension10.3HLA-DQA1, HLA-DRB1, MBL2
22ovarian papillary cystadenoma10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
23elephantiasis10.3
24aseptic osteitis10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
25oculogyric crisis10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
26multicentric castleman disease10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
27x-linked congenital generalized hypertrichosis10.3HLA-DQB1, HLA-DRB1
28achilles bursitis10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
29lethal midline granuloma10.3HLA-DQA1, HLA-DQB1, HLA-DRB1
30cerebral primitive neuroectodermal tumor10.3CD68, HBA1
31temporal lobe neoplasm10.2CD68, HBA1
32malignant type ab thymoma10.2CD68, HBA1
33spinal cord astrocytoma10.2CD68, HBA1
34spindle cell liposarcoma10.2CD68, HBA1
35breast intracanalicular fibroadenoma10.2HBA1, PDPN
36breast secretory carcinoma10.2HBA1, PDPN
37cholelithiasis10.2CD68, HBA1
38filarial elephantiasis10.2
39selective igm deficiency disease10.2HLA-DQA1, HLA-DQB1
40glutathionuria10.2HLA-DQB1, HLA-DQB2
41adult cerebellar neoplasm10.1HBA1, PDPN
42idiopathic central precocious puberty10.1HLA-DQB1, HLA-DRB1
43mononeuritis of upper limb10.1HLA-DQB1, HLA-DRB1
44foster-kennedy syndrome10.1HLA-DQB1, HLA-DQB2, HLA-DRB1
45connective tissue benign neoplasm10.1CD68, HBA1
46papillary adenoma10.0CD68, HBA1
47cervix uteri carcinoma in situ9.9HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
48leydig cell tumor9.9HBA1, PDPN
49lymphedema9.9
50filariasis9.9

Graphical network of the top 20 diseases related to Podoconiosis:



Diseases related to podoconiosis

Symptoms & Phenotypes for Podoconiosis

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Clinical features from OMIM:

614590

MGI Mouse Phenotypes related to Podoconiosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.6CDKAL1, PAH, PDPN, PPARA, RUNX1T1, SDC1

Drugs & Therapeutics for Podoconiosis

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Drugs for Podoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PetrolatumapprovedPhase 3898009-03-8
Synonyms:
Multi-hydrocarbon
Paraffinum album
Paraffinum flavum
Petrolatum base
Petrolatum, white
 
Petrolatum,amber
Petrolatum,white
Petroleum jelly
Soft paraffin
White petrolatum
White, soft paraffin
Yellow soft paraffin
2
Glycerolexperimental, approvedPhase 322356-81-5753
Synonyms:
1,2,3-Trihydroxypropane
1,2,3-propanetriol
1,2,3-trihydroxypropane
Bulbold
Cristal
E 422
Emery 916
Glyceol Opthalgan
Glycerin
Glycerin, anhydrous
Glycerin,anhydrous
Glycerine
Glycerinum
 
Glyceritol
Glycerol
Glycyl alcohol
Glyrol
Glysanin
IFP
Incorporation factor
Mackstat H 66
Monoctanoin component D
Osmoglyn
Pricerine 9091
Propanetriol
RG-S
Trihydroxypropane
Tryhydroxypropane
3Sodium hypochloritePhase 342
4Protective AgentsPhase 37190
5DisinfectantsPhase 3547
6Anti-Infective AgentsPhase 321402
7EusolPhase 342

Interventional clinical trials:

idNameStatusNCT IDPhase
1An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With PodoconiosisCompletedNCT02839772Phase 3
2Promoting Consistent Shoe Use Among Children At High Risk for PodoconiosisCompletedNCT01160523
3Genetic and Other Aspects of PodoconiosisNot yet recruitingNCT01939431

Search NIH Clinical Center for Podoconiosis

Genetic Tests for Podoconiosis

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Anatomical Context for Podoconiosis

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MalaCards organs/tissues related to Podoconiosis:

36
Skin, Testes

Publications for Podoconiosis

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Articles related to Podoconiosis:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Willingness to pay for footwear, and associated factors related to podoconiosis in northern Ethiopia. (27620919)
2016
2
Dual Perspectives On Stigma: Reports of Experienced and Enacted Stigma by Those Affected and Unaffected by Podoconiosis. (27747202)
2016
3
Burden assessment of podoconiosis in Wayu Tuka woreda, east Wollega zone, western Ethiopia: a community-based cross-sectional study. (27670520)
2016
4
Detecting and staging podoconiosis cases in North West Cameroon: positive predictive value of clinical screening of patients by community health workers and researchers. (27650390)
2016
5
Using Qualitative Methods to Explore Lay Explanatory Models, Health-Seeking Behaviours and Self-Care Practices of Podoconiosis Patients in North-West Ethiopia. (27536772)
2016
6
Association Between Causal Beliefs and Shoe Wearing to Prevent Podoconiosis: A Baseline Study. (26928843)
2016
7
Preparing for and Executing a Randomised Controlled Trial of Podoconiosis Treatment in Northern Ethiopia: The Utility of Rapid Ethical Assessment. (26967654)
2016
8
Podoconiosis in Rural Tanzania. (27385665)
2016
9
Measuring elimination of podoconiosis, endemicity classifications, case definition and targets: an international Delphi exercise. (26185194)
2015
10
Reasons for loss to follow-up of patients with podoconiosis in the Amhara Region, northern Ethiopia. (25576138)
2015
11
Depression and disability in people with podoconiosis: a comparative cross-sectional study in rural Northern Ethiopia. (26113669)
2015
12
The feasibility of eliminating podoconiosis. (26600613)
2015
13
Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. (26119541)
2015
14
Podoconiosis treatment in northern Ethiopia (GoLBet): study protocol for a randomised controlled trial. (26177812)
2015
15
Mapping and Modelling the Geographical Distribution and Environmental Limits of Podoconiosis in Ethiopia. (26222887)
2015
16
Extent of podoconiosis-related stigma in Wolaita Zone, Southern Ethiopia: a cross-sectional study. (25485190)
2014
17
Modelling environmental factors correlated with podoconiosis: a geospatial study of non-filarial elephantiasis. (24946801)
2014
18
Histopathological and immunohistochemical features of nodular podoconiosis. (25401490)
2014
19
How 'The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks' has underpinned progress in podoconiosis research. (25059525)
2014
20
Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping. (25404069)
2014
21
Podoconiosis patients' willingness to pay for treatment services in Northwest Ethiopia: potential for cost recovery. (24642085)
2014
22
Integrated mapping of lymphatic filariasis and podoconiosis: lessons learnt from Ethiopia. (25164687)
2014
23
Mental distress and podoconiosis in Northern Ethiopia: a comparative cross-sectional study. (25062906)
2014
24
How soil scientists help combat podoconiosis, a neglected tropical disease. (24828083)
2014
25
Barriers to access and re-attendance for treatment of podoconiosis: a qualitative study in northern Ethiopia. (25540135)
2014
26
Ten years of podoconiosis research in Ethiopia. (24130908)
2013
27
Development of a scale to measure stigma related to podoconiosis in Southern Ethiopia. (23556435)
2013
28
Individual correlates of podoconiosis in areas of varying endemicity: a case-control study. (24340109)
2013
29
Spatial distribution of podoconiosis in relation to environmental factors in Ethiopia: a historical review. (23874587)
2013
30
Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss. (23445314)
2013
31
Stigma towards a Neglected Tropical Disease: Felt and enacted Stigma Scores among Podoconiosis Patients in Northern Ethiopia. (24330684)
2013
32
Occupational podoconiosis. (24772719)
2013
33
Podoconiosis and soil-transmitted helminths (STHs): double burden of neglected tropical diseases in Wolaita zone, rural Southern Ethiopia. (23516659)
2013
34
The impact of podoconiosis on quality of life in Northern Ethiopia. (23866905)
2013
35
Community-based survey of podoconiosis in Bedele Zuria woreda, west Ethiopia. (24030111)
2013
36
Podoconiosis in East and West Gojam Zones, northern Ethiopia. (22816005)
2012
37
The association of beliefs about heredity with preventive and interpersonal behaviors in communities affected by podoconiosis in rural Ethiopia. (22826482)
2012
38
Addressing the neglected tropical disease podoconiosis in Northern Ethiopia: lessons learned from a new community podoconiosis program. (22428078)
2012
39
Using a "genomics tool" to develop disease prevention strategy in a low-income setting: lessons from the podoconiosis research project. (22430163)
2012
40
Factors related to discontinued clinic attendance by patients with podoconiosis in southern Ethiopia: a qualitative study. (23095311)
2012
41
Launch of the international podoconiosis initiative. (22423883)
2012
42
Podoconiosis, a neglected tropical disease. (22744921)
2012
43
Parasitological, serological and clinical evidence for high prevalence of podoconiosis (non-filarial elephantiasis) in Midakegn district, central Ethiopia. (22487446)
2012
44
Patients' perceptions of podoconiosis causes, prevention and consequences in East and West Gojam, Northern Ethiopia. (23020758)
2012
45
HLA class II locus and susceptibility to podoconiosis. (22455414)
2012
46
Podoconiosis: the forgotten tropical lymphedema. (23008936)
2012
47
Burden of podoconiosis in poor rural communities in Gulliso woreda, West Ethiopia. (21666795)
2011
48
Images in clinical medicine. Podoconiosis. (21428762)
2011
49
Podoconiosis: an experience from Tigray, Northern Ethiopia. (21679822)
2011
50
A qualitative study on stigma and coping strategies of patients with podoconiosis in Wolaita zone, Southern Ethiopia. (24038367)
2011

Variations for Podoconiosis

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Expression for genes affiliated with Podoconiosis

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Search GEO for disease gene expression data for Podoconiosis.

Pathways for genes affiliated with Podoconiosis

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Pathways related to Podoconiosis according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
2
Show member pathways
9.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
39.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
49.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
5
Show member pathways
9.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
69.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
79.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
8
Show member pathways
8.9HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, INSRR
98.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, MBL2
108.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, MBL2
11
Show member pathways
8.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
12
Show member pathways
8.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
138.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
14
Show member pathways
8.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
158.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
16
Show member pathways
8.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
17
Show member pathways
8.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
188.1HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, NEGR1, SDC1

GO Terms for genes affiliated with Podoconiosis

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Cellular components related to Podoconiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:00306699.3HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
2endocytic vesicle membraneGO:00306669.3HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:00125079.3HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
4Golgi membraneGO:00001399.3HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
5integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.3HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
6MHC class II protein complexGO:00426139.2HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
7endosome membraneGO:00100089.1CD68, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2
8trans-Golgi network membraneGO:00325888.8HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1, SLC24A5
9lysosomal membraneGO:00057658.7CD68, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
10transport vesicle membraneGO:00306588.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1

Biological processes related to Podoconiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00069559.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2
2antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.3HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
3interferon-gamma-mediated signaling pathwayGO:00603339.2HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
4T cell costimulationGO:00312959.2HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1
5T cell receptor signaling pathwayGO:00508528.6HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRB1

Molecular functions related to Podoconiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.6HLA-DQA1, HLA-DQB1, HLA-DRB1
2MHC class II receptor activityGO:00323959.3HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2

Sources for Podoconiosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet