MCID: PMS001
MIFTS: 63

Poems Syndrome malady

Categories: Rare diseases, Neuronal diseases, Blood diseases, Cancer diseases, Immune diseases, Skin diseases, Bone diseases

Aliases & Classifications for Poems Syndrome

About this section
Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Poems Syndrome:

Name: Poems Syndrome 10 45 47 12 51 36 65
Osteosclerotic Myeloma 51 65
Crow-Fukase Syndrome 45 51
Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome 45
 
Polyneuropathy-Endocrinopathy-Plasma Cell Dyscrasia Syndrome 51
Polyneuropathy Organomegaly 45
Takatsuki Syndrome 51
Pep Syndrome 51

Characteristics:

Orphanet epidemiological data:

51
poems syndrome:
Age of onset: Adult

Classifications:



External Ids:

Disease Ontology10 DOID:14039
MeSH36 D016878
NCIt42 C80303
Orphanet51 2905
SNOMED-CT59 79268002
ICD10 via Orphanet28 D47.7
MESH via Orphanet37 D016878
UMLS via Orphanet66 C0085404, C1510415
UMLS65 C0085404

Summaries for Poems Syndrome

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NIH Rare Diseases:45 Poems syndrome is a rare, mulitisystem disorder. poems stands for the disorder's features, which may include polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. signs and symptoms may include progressive sensorimotor polyneuropathy; enlarged liver, spleen, and/or lymph nodes; a disorder of the endocrine glands (often with multiple abnormalities); a monoclonal plasma cell proliferative disorder; and darkening of the skin (hyperpigmentation). various other symptoms may also occur and may vary among affected people. the underlying cause of the disorder is not well understood. poems syndrome is a chronic disorder, with a median survival time of 8-14 years. there is no standard treatment; management depends on the underlying plasma cell disorder and may include radiation therapy, chemotherapy, and/or hematopoietic cell transplantation. last updated: 7/20/2015

MalaCards based summary: Poems Syndrome, also known as osteosclerotic myeloma, is related to polycythemia and lateral sclerosis, and has symptoms including decreased nerve conduction velocity, anterior hypopituitarism and thickened skin. An important gene associated with Poems Syndrome is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways are Signaling events mediated by TCPTP and Glypican 1 network. Affiliated tissues include skin, liver and bone, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Wikipedia:68 POEMS syndrome (also known as Crow–Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare... more...

Related Diseases for Poems Syndrome

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Diseases related to Poems Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 295)
idRelated DiseaseScoreTop Affiliating Genes
1polycythemia30.1IL1B, TNF
2lateral sclerosis29.2IL1B, IL6, TNF
3myocardial infarction29.0FGF2, IL1B, IL6, VEGFA
4rheumatoid arthritis28.6IL1B, IL6, TNF, VEGFA
5primary gastrointestinal melanoma10.5IL6, VEGFA
6eccrine sweat gland neoplasm10.5IL6, VEGFA
7childhood kidney cell carcinoma10.5IL6, VEGFA
8polyneuropathy10.5
9protein s deficiency10.5IL6, VEGFA
10chronic venous leg ulcers10.4FGF2, VEGFA
11pyrimidine metabolic disorder10.4IL6, VEGFA
12intraocular lymphoma10.4IL6, VEGFA
13inherited metabolic disorder10.4FGF2, VEGFA
14grayson-wilbrandt corneal dystrophy10.4FGF2, VEGFA
15corneal abscess10.4IL1B, IL6
16retinitis pigmentosa10.4IL6, VEGFA
17neonatal period electroclinical syndrome10.4IL1B, IL6
18hemoglobin c disease10.4IL1B, IL6
19large intestine adenocarcinoma10.4FGF2, VEGFA
20retinal microaneurysm10.4IL6, VEGFA
21granulomatous amebic encephalitis10.4IL1B, IL6
22glycerol kinase deficiency, adult form10.4FGF2, VEGFA
23optic neuritis10.4IL1B, IL6
24chronic monocytic leukemia10.4IL1B, IL6
25eyelid neoplasm10.4IL1B, IL6
26ulcer of lower limbs10.4IL1B, IL6
27malignant conjunctiva melanoma10.4FGF2, VEGFA
28human granulocytic anaplasmosis10.4IL1B, IL6
29immune-complex glomerulonephritis10.4FGF2, IL6
30cystic echinococcosis10.4IL1B, IL6
31alcoholic gastritis10.3IL1B, IL6
32tuberculous uveitis10.3TNF, VEGFA
33expressive language disorder10.3FGF2, VEGFA
34hemangioma10.3
35soft tissue sarcoma childhood10.3TNF, VEGFA
36endotheliitis10.3
37cutaneous paget's disease10.3IL1B, IL6
38intermediate dend syndrome10.3IL6, TNF
39thoracic aortic aneurysm10.3TNF, VEGFA
40crohn's disease10.3IL6, TNF
41hidrocystoma10.3FGF2, IL6
42malignant sertoli-leydig cell tumor of ovary10.3IL6, TNF
43solitary osseous plasmacytoma10.3IL6, VEGFA
44posterior valve urethra10.3IL6, TNF
45t cell immunodeficiency primary10.3IL6, TNF
46parovarian cyst10.3IL6, TNF
47myoma10.3TNF, VEGFA
48precursor b lymphoblastic lymphoma/leukemia10.3IL6, TNF
49collagenous colitis10.3IL6, TNF
50ischemic optic neuropathy10.3IL6, TNF

Graphical network of the top 20 diseases related to Poems Syndrome:



Diseases related to poems syndrome

Symptoms for Poems Syndrome

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Symptoms:

 51 (show all 23)
  • thick skin/pachydermia/orange skin
  • irregular/in bands/reticular skin hyperpigmentation
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • lymphadenopathy/polyadenopathies
  • hypothalamic-hypophyseal axis functional anomalies/hypopituitarism
  • nerve conduction abnormality
  • agammaglobulinemia/hypogammaglobulinemia/b-cell deficiency
  • gynecomastia/breast/mammary gland enlargement/hyperplasia
  • hirsutism/hypertrichosis/increased body hair
  • arteriovenous malformations/vascular malformations (excluding port-wine stains)
  • lymphedema
  • hypothyroidy
  • insulin-independent/type 2 diabetes
  • late puberty/hypogonadism/hypogenitalism
  • precocious menopause/secondary amenorrhea
  • osteosclerosis/osteopetrosis/bone condensation
  • bone/osseous neoplasm/tumor/carcinoma/cancer
  • tapered fingers
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • decreased body hair/axillar/pubic hairlessness
  • renal disease/nephropathy
  • cortico-adrenal hypoplasia/insufficiency

HPO human phenotypes related to Poems Syndrome:

(show all 20)
id Description Frequency HPO Source Accession
1 decreased nerve conduction velocity hallmark (90%) HP:0000762
2 anterior hypopituitarism hallmark (90%) HP:0000830
3 thickened skin hallmark (90%) HP:0001072
4 splenomegaly hallmark (90%) HP:0001744
5 hepatomegaly hallmark (90%) HP:0002240
6 lymphadenopathy hallmark (90%) HP:0002716
7 decreased antibody level in blood hallmark (90%) HP:0004313
8 irregular hyperpigmentation hallmark (90%) HP:0007400
9 gynecomastia typical (50%) HP:0000771
10 hypothyroidism typical (50%) HP:0000821
11 secondary amenorrhea typical (50%) HP:0000869
12 hypertrichosis typical (50%) HP:0000998
13 lymphedema typical (50%) HP:0001004
14 type ii diabetes mellitus typical (50%) HP:0005978
15 neoplasm of the skeletal system typical (50%) HP:0010622
16 increased bone mineral density typical (50%) HP:0011001
17 arteriovenous malformation typical (50%) HP:0100026
18 nephropathy occasional (7.5%) HP:0000112
19 tapered finger occasional (7.5%) HP:0001182
20 primary adrenal insufficiency occasional (7.5%) HP:0008207

Drugs & Therapeutics for Poems Syndrome

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Drugs for Poems Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Pioglitazoneapproved, investigationalPhase 2419111025-46-84829
Synonyms:
(+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+/-)-5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione
(+/-)-5-[p-[2-(ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione
105355-27-9
111025-46-8
198077-89-3
2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]- (9CI)
5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione
5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
5-[[4-[2-[(5-ethyl-2-pyridyl)]ethoxy]phenyl]methyl]thiazolidine- 2,4-dione
5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
AB1004597
AC-1021
AC1L1J1Q
AD 4833
AD-4833
Actos
Actos (TN)
Actost
BRD-A48430263-003-02-4
BSPBio_002723
C07675
C19H20N2O3S
CHEBI:8228
CHEMBL595
CID4829
D08378
DB01132
Duetact
Glustin
HMS2089H14
HS-0047
 
HSDB 7322
I06-0089
KBio2_002103
KBio2_004671
KBio2_007239
KBio3_001943
KBioGR_001619
KBioSS_002103
LS-151327
MolPort-002-508-211
NCGC00163128-01
NCGC00163128-02
Pioglitazona
Pioglitazona [INN-Spanish]
Pioglitazone
Pioglitazone HCl
Pioglitazone Hydrochloride
Pioglitazone [BAN:INN]
Pioglitazone [Ban:Inn]
Pioglitazone [INN:BAN]
Pioglitazonum
Pioglitazonum [INN-Latin]
SPBio_001897
Spectrum2_001679
Spectrum3_001002
Spectrum4_001130
Spectrum5_001480
Spectrum5_002067
Spectrum_001623
U 72107
U 72107A
U-72107
U72,107A
UNII-X4OV71U42S
Zactos
nchembio790-comp10
pioglitazone (INN)
pioglitazone HCl
2
Dexamethasoneapproved, investigationalPhase 2190950-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Baycadron
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
Dexameth
Dexamethansone
 
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone acetate
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone sodium phosphate
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamethsone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
Ozurdex
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
3
LenalidomideapprovedPhase 2674191732-72-6216326
Synonyms:
1-oxo-2-(2,6-Dioxopiperidin-3-yl)-4-aminoisoindoline
191732-72-6
3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione
3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
346670-73-3
443912-14-9
AC-914
AC1L50II
AKOS005146276
ALBB-015321
Bio-0168
C467567
CC 5013
CC-5013
CC-5013, Revlimid, Lenalidomide
CC5013
CDC 501
CDC-501
CDC-5013
CHEMBL848
CID216326
Celgene brand of lenalidomide
D04687
 
DB00480
EC-000.2340
ENMD-0997
I06-0831
IMID-1
IMID-5013
IMiD3
IMiD3 cpd
IMid-1
LS-184040
Lenalidomide
Lenalidomide (USAN/INN)
Lenalidomide [USAN]
MolPort-003-848-370
NCGC00167491-01
NSC747972
Revamid
Revimid
Revlimid
Revlimid (Celgene)
Revlimid (TN)
S1029_Selleck
STK639603
Thalidomide analog CC-5013
UNII-F0P408N6V4
lenalidomide
4Insulin, Globin ZincPhase 24278
5Hypoglycemic AgentsPhase 24503
6insulinPhase 24278
7Contraceptives, OralPhase 23734
8Hormone AntagonistsPhase 210002
9HIV Protease InhibitorsPhase 24558
10glucocorticoidsPhase 23896
11HormonesPhase 211748
12Immunologic FactorsPhase 218483
13Protease InhibitorsPhase 24558
14Peripheral Nervous System AgentsPhase 218510
15Immunosuppressive AgentsPhase 210422
16Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 29988
17Gastrointestinal AgentsPhase 26401
18AntiemeticsPhase 23213
19Dexamethasone acetatePhase 219091177-87-3
20Angiogenesis Modulating AgentsPhase 23611
21Angiogenesis InhibitorsPhase 23688
22Anti-Infective AgentsPhase 217220
23Anti-Bacterial AgentsPhase 29140
24Anti-Inflammatory AgentsPhase 28478
25Dexamethasone 21-phosphatePhase 21909
26BB 1101Phase 21909
27Antineoplastic Agents, HormonalPhase 24256
28
Maravirocapproved, investigational135376348-65-13002977
Synonyms:
376348-65-1
4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide
4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
674782-29-7
AC-558
AC1MHEFQ
CHEBI:537583
CHEMBL1201187
CHEMBL256907
CID3002977
Celsentri
Celsentri(TM)
DB04835
Isopropyl, 4,4-difluoro-N-((1S)-3-{(1R,3s,5S)-3-(3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)octan-8-yl}-1-phenylpropyl)cyclohexanecarboxamide
 
LS-182818
MVC
Maraviroc
Maraviroc [USAN]
PRO 140 & Maraviroc
PRO 140 (Anti-CCR5 monoclonal antibody) & exo-4,4-Difluoro-N-[3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1(S)-phenylpropyl]cyclohexanecarboxamide
Selzentry
Selzentry(TM)
UK 427857
UK-427,857
UK-427,857 maraviroc (MVC)
UK-427857
UNII-MD6P741W8A
exo-4,4-Difluoro-N-[3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1(S)-phenylpropyl]cyclohexanecarboxamide
maraviroc
29Anti-Retroviral Agents2794
30Antiviral Agents8071
31Cephalosporins99
32Antibiotics, Antitubercular5971
33Antitubercular Agents1061

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pioglitazone Or Exercise to Treat Mild Cognitive Impairment (MCI)CompletedNCT00736996Phase 2
2POEMS Syndrome Treatment With LenalidomideRecruitingNCT01639898Phase 2
3The Treatment of Lenalidomide in Patients With POEMS SyndromeRecruitingNCT00971685Phase 2
4Efficacy and Safety of Lenalidomide as a Treatment for Recurrent or Refractory POEMS Syndrome TrialRecruitingNCT02193698Phase 2
5Study to Evaluate Lenalidomide Plus Dexamethasone in Patients With Newly Diagnosed POEMS SyndromeActive, not recruitingNCT01816620Phase 2
6Prospective Observational Epidemiologic Study of Maraviroc's SafetyRecruitingNCT00665561
7Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for AchalasiaActive, not recruitingNCT01750385

Search NIH Clinical Center for Poems Syndrome


Cochrane evidence based reviews: poems syndrome

Genetic Tests for Poems Syndrome

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Anatomical Context for Poems Syndrome

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MalaCards organs/tissues related to Poems Syndrome:

33
Skin, Liver, Bone, Lymph node, Spleen, Endothelial, Lung

Animal Models for Poems Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Poems Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5EPO, IL6, TNF, VEGFA
2MP:00020068.3FGF2, IL1B, IL6, TNF, VEGFA
3MP:00107718.0EPO, IL1B, IL6, TNF, VEGFA
4MP:00053907.9FGF2, IL1B, IL6, TNF, VEGFA
5MP:00053767.3EPO, FGF2, IL1B, IL6, TNF, VEGFA
6MP:00107687.2EPO, FGF2, IL1B, IL6, TNF, VEGFA
7MP:00053857.0EPO, FGF2, IL1B, IL6, TNF, VEGFA
8MP:00053976.8EPO, FGF2, IL1B, IL6, TNF, VEGFA

Publications for Poems Syndrome

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Articles related to Poems Syndrome:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Risk factors for and outcomes of patients with POEMS syndrome who experience progression after first-line treatment. (26669974)
2016
2
Altered axonal excitability properties and nerve edema in POEMS syndrome. (25735476)
2015
3
POEMS syndrome - A case report revealing a complex evolving diagnosis. (25678977)
2015
4
POEMS Syndrome: A Rare Disease With A Challenging Diagnosis. (26742203)
2015
5
Pentraxin-3 and VEGF in POEMS syndrome: a 2-year longitudinal study. (25447599)
2014
6
Computed tomography assessment of bone lesions in patients with POEMS syndrome. (25253619)
2014
7
The characteristics of ascites in patients with POEMS syndrome. (23811954)
2013
8
Outcomes of patients with POEMS syndrome treated initially with radiation. (23699599)
2013
9
POEMS syndrome and Castleman disease. (24006526)
2013
10
POEMS syndrome presenting with acute demyelinating polyneuropathy: increased terminal latency indices and uniform demyelination. (23812201)
2013
11
Glomeruloid hemangiomas in the absence of POEMS syndrome. (22443389)
2012
12
Hemangioma in POEMS syndrome: an atypical clinical and histological presentation. (21749469)
2012
13
POEMS syndrome with prominent acute axonal lesions. (21982617)
2012
14
Comparison of imaging methods in POEMS syndrome. (22580861)
2012
15
Mobilization of PBSCs in poor mobilizers with POEMS syndrome using G-CSF with plerixafor. (22609884)
2012
16
The clinical study of POEMS syndrome in China. (20424579)
2010
17
Crow-Fukase (POEMS) syndrome]. (20420180)
2010
18
POEMS syndrome, congestive heart failure and thalidomide -food for thought. (20823658)
2010
19
A case of POEMS syndrome with mixed hyaline vascular and plasma cell type Castleman's disease. (19670555)
2009
20
POEMS syndrome with an isolated lytic lesion and glomeruloid hemangiomas: report of one case]. (19701559)
2009
21
Endocrinopathy in POEMS syndrome: the Mayo Clinic experience. (17605964)
2007
22
A case of POEMS syndrome with cystoid macular edema. (15767082)
2005
23
Polyneuropathy in POEMS syndrome: role of angiogenic factors in the pathogenesis. (15975949)
2005
24
Restricted use of Vlambda genes in POEMS syndrome. (15075094)
2004
25
Thalidomide in POEMS syndrome: case report. (15114600)
2004
26
POEMS syndrome, fibrinogen, and ischemic stroke: a critical point of view. (14732636)
2004
27
POEMS syndrome. (14715103)
2003
28
POEMS syndrome: a case report and discussion. (11378655)
2001
29
Glomeruloid haemangioma and POEMS syndrome. (11572909)
2001
30
Pulmonary hypertension in POEMS syndrome: a new feature mediated by cytokines. (9517610)
1998
31
Abnormal FSH hypersecretion as an endocrinological manifestation of POEMS syndrome. (9625458)
1998
32
Long term melphalan-prednisolone chemotherapy for POEMS syndrome. (9328260)
1997
33
Myeloneuropathy in POEMS syndrome. (8941279)
1996
34
Acute arterial obliteration: a new feature of the POEMS syndrome? (8699962)
1996
35
Pro-inflammatory cytokines: a pathogenic key of POEMS syndrome]. (8881441)
1996
36
Amyotrophic lateral sclerosis associated with multiple myeloma, endocrinopathy and skin changes suggestive of a POEMS syndrome variant. (7595623)
1995
37
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995
38
POEMS syndrome in a female Italian patient. A case report. (8539476)
1995
39
POEMS syndrome: clinical, pathological and immunological study of a case. (7708142)
1994
40
Alopecia as a rare cutaneous manifestation of POEMS syndrome. (7918001)
1994
41
Castleman disease in POEMS syndrome with elevated interleukin-6. (8499003)
1993
42
POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report. (1953537)
1991
43
Renal involvement in POEMS syndrome. (1944731)
1991
44
POEMS syndrome with idiopathic flushing mimicking carcinoid syndrome. (2029023)
1991
45
POEMS syndrome: a rarely diagnosed multisystem disorder. (2163715)
1990
46
The endocrinopathy of POEMS syndrome. (2555917)
1989
47
Refractory ascites due to POEMS syndrome. (2535829)
1989
48
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
49
Renal ultrasound in POEMS syndrome. (3920286)
1985
50

Variations for Poems Syndrome

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Expression for genes affiliated with Poems Syndrome

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Search GEO for disease gene expression data for Poems Syndrome.

Pathways for genes affiliated with Poems Syndrome

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Pathways related to Poems Syndrome according to GeneCards Suite gene sharing:

(show all 49)
idSuper pathwaysScoreTop Affiliating Genes
19.6IL6, VEGFA
29.5FGF2, VEGFA
39.5FGF2, VEGFA
49.5FGF2, VEGFA
59.5FGF2, VEGFA
69.5FGF2, VEGFA
79.5IL1B, IL6
89.5IL1B, IL6
99.4IL6, TNF
109.4IL6, TNF
119.3IL1B, TNF
129.3IL1B, TNF
13
Show member pathways
9.3IL1B, TNF
149.3IL1B, TNF
159.1FGF2, IL6, VEGFA
169.0IL6, TNF, VEGFA
178.9FGF2, TNF, VEGFA
18
Show member pathways
8.9IL1B, IL6, TNF
19
Show member pathways
8.9IL1B, IL6, TNF
208.9IL1B, IL6, TNF
218.9IL1B, IL6, TNF
228.9IL1B, IL6, TNF
23
Show member pathways
8.9IL1B, IL6, TNF
248.9IL1B, IL6, TNF
25
Show member pathways
8.9IL1B, IL6, TNF
268.9IL1B, IL6, TNF
278.9IL1B, IL6, TNF
288.9IL1B, IL6, TNF
29
Show member pathways
8.9IL1B, IL6, TNF
30
Show member pathways
8.9IL1B, IL6, TNF
318.9IL1B, IL6, TNF
328.9IL1B, IL6, TNF
33
Show member pathways
8.9IL1B, IL6, TNF
348.9IL1B, IL6, TNF
358.9IL1B, IL6, TNF
36
Show member pathways
8.9IL1B, IL6, TNF
378.9IL1B, IL6, TNF
388.8EPO, IL6, VEGFA
398.6EPO, IL6, TNF
408.5IL1B, IL6, TNF, VEGFA
418.5IL1B, IL6, TNF, VEGFA
428.5IL1B, IL6, TNF, VEGFA
438.5FGF2, IL6, TNF, VEGFA
44
Show member pathways
8.4FGF2, IL1B, IL6, TNF
45
Show member pathways
8.4FGF2, IL1B, IL6, TNF
468.3EPO, FGF2, IL6, VEGFA
478.1EPO, IL1B, IL6, TNF
48
Show member pathways
7.6EPO, IL1B, IL6, TNF, VEGFA
49
Show member pathways
7.1EPO, FGF2, IL1B, IL6, TNF, VEGFA

GO Terms for genes affiliated with Poems Syndrome

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Biological processes related to Poems Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idNameGO IDScoreTop Affiliating Genes
1cell migration involved in sprouting angiogenesisGO:000204210.3FGF2, VEGFA
2positive regulation of protein complex assemblyGO:003133410.2TNF, VEGFA
3positive regulation of blood vessel endothelial cell migrationGO:004353610.1FGF2, VEGFA
4epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.1IL6, TNF
5positive regulation of cell divisionGO:005178110.1FGF2, VEGFA
6positive regulation of calcidiol 1-monooxygenase activityGO:006055910.0IL1B, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:005104410.0IL1B, TNF
8sequestering of triglycerideGO:003073010.0IL1B, TNF
9regulation of establishment of endothelial barrierGO:190314010.0IL1B, TNF
10positive regulation of chemokine biosynthetic processGO:004508010.0IL1B, TNF
11regulation of angiogenesisGO:004576510.0FGF2, IL6
12positive regulation of NF-kappaB import into nucleusGO:004234610.0IL1B, TNF
13negative regulation of lipid storageGO:001088810.0IL6, TNF
14positive regulation of fever generationGO:003162210.0IL1B, TNF
15negative regulation of lipid catabolic processGO:005099510.0IL1B, TNF
16positive chemotaxisGO:005091810.0FGF2, VEGFA
17negative regulation of fat cell differentiationGO:004559910.0IL6, TNF
18negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.0IL1B, TNF
19regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.9IL1B, TNF
20positive regulation of phagocytosisGO:00507669.8IL1B, TNF
21regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:00614189.8EPO, VEGFA
22response to axon injuryGO:00486789.6EPO, FGF2
23response to electrical stimulusGO:00516029.6EPO, IL6
24wound healingGO:00420609.5FGF2, IL1B, IL6
25positive regulation of DNA replicationGO:00457409.5EPO, IL6
26positive regulation of nitric oxide biosynthetic processGO:00454299.5IL1B, IL6, TNF
27positive regulation of peptidyl-serine phosphorylationGO:00331389.5IL6, TNF, VEGFA
28positive regulation of JUN kinase activityGO:00435079.4IL1B, TNF
29response to glucocorticoidGO:00513849.4IL1B, IL6, TNF
30positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.4IL1B, IL6, TNF
31positive regulation of ERK1 and ERK2 cascadeGO:00703749.4FGF2, IL1B, IL6
32positive regulation of angiogenesisGO:00457669.4FGF2, IL1B, VEGFA
33positive regulation of protein kinase B signalingGO:00518979.3FGF2, IL6, TNF
34positive regulation of smooth muscle cell proliferationGO:00486619.3FGF2, IL6, TNF
35activation of MAPK activityGO:00001879.3FGF2, IL1B, TNF
36positive regulation of interleukin-6 productionGO:00327559.3IL1B, IL6, TNF
37positive regulation of apoptotic processGO:00430659.2IL1B, IL6, TNF
38positive regulation of NF-kappaB transcription factor activityGO:00510929.2IL1B, IL6, TNF
39response to heatGO:00094089.2IL1B, IL6
40inflammatory responseGO:00069549.2IL1B, IL6, TNF
41MAPK cascadeGO:00001659.2FGF2, IL1B, TNF
42immune responseGO:00069559.1IL1B, IL6, TNF
43cellular response to lipopolysaccharideGO:00712229.1IL1B, IL6, TNF
44positive regulation of cell proliferationGO:00082848.8EPO, FGF2, IL6
45positive regulation of protein phosphorylationGO:00019348.8FGF2, IL1B, TNF, VEGFA
46response to lipopolysaccharideGO:00324968.6EPO, IL1B, IL6
47positive regulation of gene expressionGO:00106288.6FGF2, IL1B, IL6, VEGFA
48negative regulation of transcription from RNA polymerase II promoterGO:00001228.4EPO, IL1B, TNF, VEGFA
49positive regulation of transcription, DNA-templatedGO:00458938.0EPO, FGF2, IL1B, IL6, TNF
50positive regulation of transcription from RNA polymerase II promoterGO:00459447.9FGF2, IL1B, IL6, TNF, VEGFA

Sources for Poems Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet