MCID: PMS001
MIFTS: 52

Poems Syndrome malady

Categories: Rare diseases, Neuronal diseases, Blood diseases, Immune diseases, Skin diseases, Bone diseases

Aliases & Classifications for Poems Syndrome

Aliases & Descriptions for Poems Syndrome:

Name: Poems Syndrome 12 50 56 52 42 14 69
Osteosclerotic Myeloma 56 69
Crow-Fukase Syndrome 50 56
Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome 50
Polyneuropathy-Endocrinopathy-Plasma Cell Dyscrasia Syndrome 56
Polyneuropathy Organomegaly 50
Takatsuki Syndrome 56
Pep Syndrome 56

Characteristics:

Orphanet epidemiological data:

56
poems syndrome
Age of onset: Adult,Elderly; Age of death: adult,elderly,normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:14039
MeSH 42 D016878
NCIt 47 C80303
SNOMED-CT 64 79268002
Orphanet 56 ORPHA2905
MESH via Orphanet 43 D016878
UMLS via Orphanet 70 C0085404 C1510415
ICD10 via Orphanet 34 D47.7
UMLS 69 C0085404

Summaries for Poems Syndrome

NIH Rare Diseases : 50 poems syndrome is a rare, mulitisystem disorder. poems stands for the disorder's features, which may include polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. signs and symptoms may include progressive sensorimotor polyneuropathy; enlarged liver, spleen, and/or lymph nodes; a disorder of the endocrine glands (often with multiple abnormalities); a monoclonal plasma cell proliferative disorder; and darkening of the skin (hyperpigmentation). various other symptoms may also occur and may vary among affected people. the underlying cause of the disorder is not well understood. poems syndrome is a chronic disorder, with a median survival time of 8-14 years. there is no standard treatment; management depends on the underlying plasma cell disorder and may include radiation therapy, chemotherapy, and/or hematopoietic cell transplantation. last updated: 7/20/2015

MalaCards based summary : Poems Syndrome, also known as osteosclerotic myeloma, is related to neuropathy and choroiditis. An important gene associated with Poems Syndrome is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Aspirin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and liver, and related phenotypes are cardiovascular system and integument

Wikipedia : 71 POEMS syndrome (also known as Crow–Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare... more...

Related Diseases for Poems Syndrome

Diseases related to Poems Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
id Related Disease Score Top Affiliating Genes
1 neuropathy 30.1 IL1B IL6 TNF
2 choroiditis 29.8 IL1B IL6 TNF
3 papilledema 29.5 IL6 TNF
4 myocardial infarction 29.3 IL1B IL6 TNF VEGFA
5 osteonecrosis 29.3 IL1B IL6 TNF
6 rheumatoid arthritis 29.0 IL1B IL6 TNF VEGFA
7 polyneuropathy 10.3
8 craniosynostosis, type 1 10.3 IL6 VEGFA
9 cardiac tuberculosis 10.2 IL6 VEGFA
10 prinzmetal's variant angina 10.2 IL6 VEGFA
11 oculomotor nerve paralysis 10.2 IL1B IL6
12 hemangioma 10.2
13 endotheliitis 10.2
14 conjugate gaze palsy 10.2 IL6 VEGFA
15 common peroneal nerve lesion 10.2 IL1B IL6
16 retinal degeneration 10.2 IL6 VEGFA
17 adrenal neuroblastoma 10.2 MYOM2 VEGFA
18 hyperinsulinism 10.2 ANGPT2 VEGFA
19 childhood electroclinical syndrome 10.2 IL1B IL6
20 submucous uterine fibroid 10.2 ANGPT2 VEGFA
21 laryngotracheoesophageal cleft type 2 10.2 IL1B IL6
22 hypersensitivity syndrome, carbamazepine-induced 10.2 ANGPT2 VEGFA
23 cryptosporidiosis 10.2 IL6 VEGFA
24 laryngeal adenoid cystic carcinoma 10.2 MYOM2 VEGFA
25 radiation induced angiosarcoma of the breast 10.2 ANGPT2 VEGFA
26 glucosephosphate dehydrogenase deficiency 10.2 IL1B IL6
27 acute allergic sanguinous otitis media 10.2 IL6 MYOM2
28 generalized atherosclerosis 10.2 IL6 MYOM2
29 angular blepharoconjunctivitis 10.2 IL6 VEGFA
30 bullous retinoschisis 10.2 IL1B IL6
31 acute cor pulmonale 10.2 IL6 MYOM2
32 localized junctional epidermolysis bullosa, non-herlitz type 10.2 ANGPT2 VEGFA
33 carbuncle 10.2 IL1B IL6
34 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
35 dyslexia 5 10.2 IL6 TNF
36 larynx leiomyoma 10.2 IL1B IL6
37 intussusception 10.2 IL1B TNF
38 aortic atherosclerosis 10.2 IL6 TNF
39 unilateral multicystic dysplastic kidney 10.2 IL6 TNF
40 swine influenza 10.1 IL6 TNF
41 drug dependence 10.1 IL6 TNF
42 gastric leiomyoma 10.1 IL1B IL6
43 tau syndrome 10.1 IL1B TNF
44 transient tic disorder 10.1 IL6 TNF
45 glomeruloid hemangioma 10.1
46 stomatitis 10.1 IL6 MYOM2
47 stocco dos santos syndrome 10.1 IL1B TNF
48 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.1 IL1B TNF
49 spastic paraplegia 1 10.1 TNF VEGFA
50 twin-to-twin transfusion syndrome 10.1 IL1B TNF

Graphical network of the top 20 diseases related to Poems Syndrome:



Diseases related to Poems Syndrome

Symptoms & Phenotypes for Poems Syndrome

MGI Mouse Phenotypes related to Poems Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 IL6 TNF VEGFA ANGPT2 FGF2 IL1B
2 integument MP:0010771 9.55 ANGPT2 IL1B IL6 TNF VEGFA
3 neoplasm MP:0002006 9.35 FGF2 IL1B IL6 TNF VEGFA
4 vision/eye MP:0005391 9.02 ANGPT2 FGF2 IL6 TNF VEGFA

Drugs & Therapeutics for Poems Syndrome

Drugs for Poems Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Everolimus Approved Phase 4 159351-69-6 6442177
4
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
5 Peripheral Nervous System Agents Phase 4,Phase 2
6 Anti-Bacterial Agents Phase 4,Phase 2
7 Anti-Infective Agents Phase 4,Phase 2
8 Immunosuppressive Agents Phase 4,Phase 2
9 Anti-Inflammatory Agents Phase 4,Phase 2
10 Antibiotics, Antitubercular Phase 4
11 Anticoagulants Phase 4,Phase 2
12 Analgesics Phase 4
13 Cyclooxygenase Inhibitors Phase 4
14 Analgesics, Non-Narcotic Phase 4
15 Platelet Aggregation Inhibitors Phase 4
16 Fibrinolytic Agents Phase 4
17 Antifungal Agents Phase 4
18 Anti-Inflammatory Agents, Non-Steroidal Phase 4
19 Antipyretics Phase 4
20 Antirheumatic Agents Phase 4
21
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
22
Lenalidomide Approved Phase 2 191732-72-6 216326
23
Pioglitazone Approved, Investigational Phase 2 111025-46-8 4829
24 Ixazomib Approved Phase 2 1072833-77-2
25
Glycine Approved, Nutraceutical, Vet_approved Phase 2 56-40-6 750
26 Dexamethasone acetate Phase 2 1177-87-3
27 glucocorticoids Phase 2
28
protease inhibitors Phase 2
29 Gastrointestinal Agents Phase 2
30 HIV Protease Inhibitors Phase 2
31 Hormone Antagonists Phase 2
32 Dexamethasone 21-phosphate Phase 2
33 Hormones Phase 2
34 Angiogenesis Inhibitors Phase 2
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
36 Angiogenesis Modulating Agents Phase 2
37 Antiemetics Phase 2
38 BB 1101 Phase 2
39 Autonomic Agents Phase 2
40 Antineoplastic Agents, Hormonal Phase 2
41 insulin Phase 2
42 Hypoglycemic Agents Phase 2
43 Insulin, Globin Zinc Phase 2
44 Chelating Agents Phase 2
45 Neurotransmitter Agents Phase 2
46 Calcium, Dietary Phase 2
47 Citrate Nutraceutical Phase 2
48
Citric Acid Nutraceutical, Vet_approved Phase 2 77-92-9 311
49
Maraviroc Approved, Investigational 376348-65-1 3002977
50 Antitubercular Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Bioresorbable Polymer-Coated EES in Patients at High Bleeding Risk Undergoing PCI Followed by 1-Month DAPT Not yet recruiting NCT03112707 Phase 4
2 The Treatment of Lenalidomide in Patients With POEMS Syndrome Unknown status NCT00971685 Phase 2
3 Study to Evaluate Lenalidomide Plus Dexamethasone in Patients With Newly Diagnosed POEMS Syndrome Completed NCT01816620 Phase 2
4 Efficacy and Safety of Lenalidomide as a Treatment for Recurrent or Refractory POEMS Syndrome Trial Completed NCT02193698 Phase 2
5 Pioglitazone Or Exercise to Treat Mild Cognitive Impairment (MCI) Completed NCT00736996 Phase 2
6 POEMS Syndrome Treatment With Lenalidomide Recruiting NCT01639898 Phase 2
7 Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome Recruiting NCT02921893 Phase 2
8 Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for Achalasia Unknown status NCT01750385
9 Prospective Observational Epidemiologic Study of Maraviroc's Safety Active, not recruiting NCT00665561

Search NIH Clinical Center for Poems Syndrome

Cochrane evidence based reviews: poems syndrome

Genetic Tests for Poems Syndrome

Anatomical Context for Poems Syndrome

MalaCards organs/tissues related to Poems Syndrome:

39
Skin, Lymph Node, Liver, Endothelial, Spleen, Bone, Bone Marrow

Publications for Poems Syndrome

Articles related to Poems Syndrome:

(show top 50) (show all 528)
id Title Authors Year
1
Safety and Efficacy of Granulocyte Colony-Stimulating Factor Monotherapy for Peripheral Blood Stem Cell Collection in POEMS Syndrome. ( 27840209 )
2017
2
Stroke and POEMS syndrome: More than a chance association. ( 27841210 )
2016
3
Treatment of Breast Cancer Accompanied by POEMS Syndrome: A Case Report. ( 28031090 )
2016
4
Longitudinal bioimpedance assessments to evaluate hydration in POEMS syndrome. ( 27125269 )
2016
5
Risk factors for and outcomes of patients with POEMS syndrome who experience progression after first-line treatment. ( 26669974 )
2016
6
Young patient with arterial thrombosis and skin changes as the onset manifestations: POEMS syndrome. ( 27738309 )
2016
7
POEMS syndrome and calciphylaxis: an unrecognized cause of abnormal small vessel calcification. ( 27068711 )
2016
8
Cranial Pachymeningeal Involvement in POEMS Syndrome: Evaluation by Pre- and Post-contrast FLAIR and T1-weighted Imaging. ( 28003622 )
2016
9
A special subtype of POEMS syndrome: IgG4 subtype. ( 27158350 )
2016
10
Kennedy Disease Misdiagnosed as Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome: A Case Report. ( 26618536 )
2016
11
OCULAR MANIFESTATIONS AND TREATMENT OUTCOMES IN CHINESE PATIENTS WITH POEMS SYNDROME. ( 27930460 )
2016
12
Glomeruloid hemangioma and POEMS syndrome. ( 27208909 )
2016
13
Diffuse large B-cell non-Hodgkin's lymphoma and osteosclerotic myeloma with features of POEMS syndrome. ( 27365880 )
2016
14
Long-term outcome of patients with POEMS syndrome: An update of the Mayo Clinic experience. ( 26972803 )
2016
15
Temporal and Spatial Correlation Between Choroidal Thickness and Visual Function in a Case of POEMS Syndrome. ( 27726462 )
2016
16
A rare case of worsening of Parkes-Weber syndrome with development of POEMS syndrome. ( 27649853 )
2016
17
POEMS syndrome: a rare case report. ( 27630082 )
2016
18
Nerve pathologic features differentiate POEMS syndrome from CIDP. ( 27799073 )
2016
19
Bone lesions in Chinese POEMS syndrome patients: imaging characteristics and clinical implications. ( 27547585 )
2016
20
Improvement of sexual function in POEMS syndrome after combination therapy of Lenalidomide and dexamethasone. ( 27317315 )
2016
21
The first case of POEMS syndrome with synchronous breast cancer: What are the associated diagnostic challenges? ( 27099730 )
2016
22
Prognostic study for overall survival in patients with newly diagnosed POEMS syndrome. ( 27338259 )
2016
23
Prominent dysautonomia in a patient with POEMS syndrome. ( 27165541 )
2016
24
Thalidomide and POEMS syndrome: a cautious step forward. ( 27496679 )
2016
25
An Occult Malignancy Behind a Demyelinating Disease: POEMS Syndrome. ( 27790622 )
2016
26
Diagnosis of POEMS syndrome in a patient with long-standing neuropathy. ( 27776962 )
2016
27
Measurement of I^-isomerized C-terminal telopeptide of type I collagen in patients with POEMS syndrome: diagnostic, prognostic, and follow-up utilities. ( 27834942 )
2016
28
High dose therapy and autologous stem cell transplantation in patients with POEMS syndrome: A retrospective study of the Plasma Cell Disorder sub-committee of the Chronic Malignancy Working Party of the European Society for Blood & Marrow Transplantation. ( 27634201 )
2016
29
Safety and efficacy of thalidomide in patients with POEMS syndrome: a multicentre, randomised, double-blind, placebo-controlled trial. ( 27496680 )
2016
30
Multiple glomeruloid hemangiomas without POEMS syndrome. ( 27126256 )
2016
31
Rapidly Progressive Polyneuropathy in a Patient With Monoclonal Gammopathy: A Case Report of POEMS Syndrome and Beyond. ( 27100445 )
2016
32
Autologous cytokine-induced killer (CIK) cell immunotherapy combined with cyclophosphamide in five patients with POEMS syndrome. ( 26660736 )
2016
33
Changes in subfoveal choroidal thickness and reduction of serum levels of vascular endothelial growth factor in patients with POEMS syndrome. ( 27707692 )
2016
34
Remarkable expression of vascular endothelial growth factor in bone marrow plasma cells of patients with POEMS syndrome. ( 27697660 )
2016
35
Multiple glomeruloid hemangiomas without POEMS syndrome. ( 27279314 )
2016
36
Acutely deteriorated extravascular volume overload during peripheral blood stem cell mobilization in POEMS syndrome: A case series with cytokine analysis. ( 26586169 )
2015
37
Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS syndrome): a paraneoplastic syndrome. ( 26634133 )
2015
38
POEMS syndrome: Update on diagnosis, risk-stratification, and management. ( 26331353 )
2015
39
An Atypical Case of POEMS Syndrome with an Osteolytic Bone Lesion. ( 26266203 )
2015
40
POEMS Syndrome With Peripheral and Central Nervous System Demyelination: Case Report. ( 25888197 )
2015
41
POEMS syndrome - A case report revealing a complex evolving diagnosis. ( 25678977 )
2015
42
Cutaneous Manifestations in POEMS Syndrome: Case Report and Review. ( 26034475 )
2015
43
POEMS syndrome associated with plasmacytoma of the clivus: "Time discovers the truth". ( 26469713 )
2015
44
Correlation between peripapillary retinal thickness and serum level of vascular endothelial growth factor in patients with POEMS syndrome. ( 26504179 )
2015
45
Vascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: retrospective cohort study. ( 26560063 )
2015
46
Prognostic value of serum heavy/light chain ratios in patients with POEMS syndrome. ( 26383741 )
2015
47
POEMS syndrome with opticneuritis as initial symptom: a case report. ( 25820707 )
2015
48
POEMS Syndrome Complicated by Extensive Calciphylaxis: A Remarkable Recovery. ( 25775638 )
2015
49
Ventriculoperitoneal shunt placement for POEMS syndrome. ( 26077937 )
2015
50
T-cell lymphoma with POEMS syndrome. ( 25663904 )
2015

Variations for Poems Syndrome

Expression for Poems Syndrome

Search GEO for disease gene expression data for Poems Syndrome.

Pathways for Poems Syndrome

Pathways related to Poems Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 ANGPT2 FGF2 IL1B IL6 TNF VEGFA
2
Show member pathways
13.31 ANGPT2 FGF2 IL1B IL6 TNF VEGFA
3
Show member pathways
13.23 ANGPT2 FGF2 IL1B IL6 TNF
4
Show member pathways
13.18 FGF2 IL1B IL6 TNF VEGFA
5
Show member pathways
13.11 ANGPT2 FGF2 IL1B IL6 TNF
6
Show member pathways
12.7 IL1B IL6 TNF VEGFA
7
Show member pathways
12.55 FGF2 IL1B IL6 TNF
8 12.44 ANGPT2 FGF2 IL6 VEGFA
9
Show member pathways
12.3 IL1B IL6 TNF
10
Show member pathways
12.3 ANGPT2 FGF2 IL1B IL6 TNF
11
Show member pathways
12.22 IL1B IL6 TNF
12
Show member pathways
12.22 IL1B IL6 TNF
13 12.18 FGF2 TNF VEGFA
14
Show member pathways
12.15 IL1B IL6 TNF
15 12.12 IL1B IL6 TNF
16
Show member pathways
12.07 IL1B IL6 TNF
17 12.07 IL6 TNF VEGFA
18
Show member pathways
12.03 IL1B IL6 TNF
19 11.98 IL1B TNF VEGFA
20 11.97 IL1B IL6 TNF VEGFA
21 11.96 FGF2 IL6 VEGFA
22 11.9 IL1B IL6 TNF
23 11.85 IL1B IL6 TNF
24
Show member pathways
11.83 IL1B IL6 TNF
25 11.79 ANGPT2 IL6 VEGFA
26 11.78 IL1B IL6 TNF
27 11.77 IL1B IL6 TNF
28 11.65 IL1B IL6 TNF
29 11.64 IL1B IL6 TNF
30 11.62 IL1B IL6 TNF VEGFA
31 11.51 IL1B IL6 TNF VEGFA
32 11.49 IL1B IL6 TNF
33 11.43 IL1B IL6 TNF
34 11.42 IL1B IL6 TNF
35 11.4 FGF2 IL6 VEGFA
36 11.38 FGF2 VEGFA
37 11.37 IL1B IL6 TNF
38
Show member pathways
11.35 IL1B TNF
39 11.28 ANGPT2 VEGFA
40 11.26 IL1B IL6
41 11.26 FGF2 IL1B IL6 TNF
42 11.23 IL1B IL6 TNF
43 11.21 IL1B IL6 TNF
44 11.16 IL1B IL6 TNF
45 11.12 FGF2 VEGFA
46 11.1 IL1B IL6 TNF
47 11.08 FGF2 VEGFA
48 11.08 FGF2 IL1B IL6 TNF VEGFA
49 11.06 ANGPT2 IL1B IL6 TNF
50 11.06 IL1B IL6 TNF

GO Terms for Poems Syndrome

Cellular components related to Poems Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ANGPT2 FGF2 IL1B IL6 TNF VEGFA
2 extracellular space GO:0005615 9.1 ANGPT2 FGF2 IL1B IL6 TNF VEGFA

Biological processes related to Poems Syndrome according to GeneCards Suite gene sharing:

(show all 44)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.94 FGF2 IL1B IL6 TNF
2 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.92 FGF2 IL1B IL6 TNF VEGFA
3 MAPK cascade GO:0000165 9.86 FGF2 IL1B TNF
4 angiogenesis GO:0001525 9.84 ANGPT2 FGF2 VEGFA
5 leukocyte migration GO:0050900 9.84 ANGPT2 IL1B TNF
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.82 FGF2 IL6 TNF
7 positive regulation of protein phosphorylation GO:0001934 9.8 IL1B TNF VEGFA
8 positive regulation of gene expression GO:0010628 9.8 IL1B IL6 TNF VEGFA
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.76 IL1B IL6 TNF
10 activation of MAPK activity GO:0000187 9.73 FGF2 IL1B TNF
11 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.72 IL1B IL6 TNF
12 positive regulation of interferon-gamma production GO:0032729 9.69 IL1B TNF
13 negative regulation of fat cell differentiation GO:0045599 9.69 IL6 TNF
14 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.68 IL1B TNF
15 positive chemotaxis GO:0050918 9.68 FGF2 VEGFA
16 regulation of angiogenesis GO:0045765 9.68 FGF2 IL6
17 protein kinase B signaling GO:0043491 9.68 IL1B TNF
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 IL1B TNF
19 positive regulation of phagocytosis GO:0050766 9.67 IL1B TNF
20 positive regulation of interleukin-8 production GO:0032757 9.66 IL1B TNF
21 positive regulation of protein complex assembly GO:0031334 9.65 TNF VEGFA
22 positive regulation of blood vessel endothelial cell migration GO:0043536 9.65 FGF2 VEGFA
23 positive regulation of NF-kappaB import into nucleus GO:0042346 9.65 IL1B TNF
24 negative regulation of lipid catabolic process GO:0050995 9.63 IL1B TNF
25 positive regulation of chemokine production GO:0032722 9.63 IL6 TNF
26 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.63 IL6 TNF VEGFA
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IL1B TNF
28 cell migration involved in sprouting angiogenesis GO:0002042 9.61 FGF2 VEGFA
29 negative regulation of blood vessel endothelial cell migration GO:0043537 9.61 ANGPT2 FGF2
30 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.6 IL1B VEGFA
31 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.59 IL1B TNF
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL1B TNF
33 positive regulation of chemokine biosynthetic process GO:0045080 9.57 IL1B TNF
34 negative regulation of lipid storage GO:0010888 9.54 IL6 TNF
35 positive regulation of MAP kinase activity GO:0043406 9.54 FGF2 TNF VEGFA
36 regulation of establishment of endothelial barrier GO:1903140 9.51 IL1B TNF
37 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.48 IL6 TNF
38 positive regulation of fever generation GO:0031622 9.43 IL1B TNF
39 positive regulation of cell division GO:0051781 9.43 FGF2 IL1B VEGFA
40 sequestering of triglyceride GO:0030730 9.4 IL1B TNF
41 positive regulation of interleukin-6 production GO:0032755 9.33 IL1B IL6 TNF
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IL1B TNF
43 positive regulation of nitric oxide biosynthetic process GO:0045429 9.13 IL1B IL6 TNF
44 positive regulation of angiogenesis GO:0045766 8.92 ANGPT2 FGF2 IL1B VEGFA

Molecular functions related to Poems Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 FGF2 VEGFA
2 growth factor activity GO:0008083 9.13 FGF2 IL6 VEGFA
3 cytokine activity GO:0005125 9.02 FGF2 IL1B IL6 TNF VEGFA

Sources for Poems Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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