MCID: PMS001
MIFTS: 51

Poems Syndrome malady

Rare diseases, Neuronal diseases, Blood diseases, Cancer diseases, Immune diseases, Skin diseases, Bone diseases categories

Aliases & Classifications for Poems Syndrome

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Sources:
51Orphanet, 65UMLS, 10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 36MeSH, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Poems Syndrome:

Name: Poems Syndrome 10 45 47 12 51 65 36
Osteosclerotic Myeloma 51 65
Crow-Fukase Syndrome 45 51
Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome 45
 
Polyneuropathy - Endocrinopathy - Plasma Cell Dyscrasia 51
Polyneuropathy Organomegaly 45
Takatsuki Syndrome 51
Pep Syndrome 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
poems syndrome:
Age of onset: Adult


External Ids:

Disease Ontology10 DOID:14039
NCIt42 C80303
MeSH36 D016878
Orphanet51 2905
SNOMED-CT59 79268002
ICD10 via Orphanet28 D47.7
MESH via Orphanet37 D016878
UMLS via Orphanet66 C0085404, C1510415

Summaries for Poems Syndrome

About this section
NIH Rare Diseases:45 Poems syndrome is a rare, mulitisystem disorder. poems stands for the disorder's features, which may include polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. signs and symptoms may include progressive sensorimotor polyneuropathy; enlarged liver, spleen, and/or lymph nodes; a disorder of the endocrine glands (often with multiple abnormalities); a monoclonal plasma cell proliferative disorder; and darkening of the skin (hyperpigmentation). various other symptoms may also occur and may vary among affected people. the underlying cause of the disorder is not well understood. poems syndrome is a chronic disorder, with a median survival time of 8-14 years. there is no standard treatment; management depends on the underlying plasma cell disorder and may include radiation therapy, chemotherapy, and/or hematopoietic cell transplantation. last updated: 7/20/2015

MalaCards based summary: Poems Syndrome, also known as osteosclerotic myeloma, is related to endotheliitis and multiple myeloma, and has symptoms including decreased nerve conduction velocity, anterior hypopituitarism and thickened skin. An important gene associated with Poems Syndrome is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways are Signaling events mediated by TCPTP and Prion diseases. Affiliated tissues include skin, bone and liver, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Wikipedia:68 POEMS syndrome(also known as Crow–Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare... more...

Related Diseases for Poems Syndrome

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Diseases related to Poems Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 308)
idRelated DiseaseScoreTop Affiliating Genes
1endotheliitis31.3IL6, TNF
2multiple myeloma30.6IL6, TNF, VEGFA
3retinitis30.4IL6, VEGFA
4diabetic ketoacidosis30.3IL1B, IL6
5vascular cancer30.3IL1B, IL6
6myocardial infarction30.0IL6, TIMP1, TNF, VEGFA
7rheumatoid arthritis29.5IL1B, IL6, TIMP1, TNF, VEGFA
8polyneuropathy10.8
9hemangioma10.7
10myeloma10.6
11glomeruloid hemangioma10.6
12osteosclerotic myeloma10.6
13extramedullary plasmacytoma10.5
14pulmonary hypertension10.5
15neuropathy10.5
16castleman disease10.5
17calciphylaxis10.4
18peripheral neuropathy10.4
19demyelinating polyneuropathy10.4
20plasmacytoma10.4
21plasma cell neoplasm10.4
22adult syndrome10.3
23chronic inflammatory demyelinating polyneuropathy10.3
24hematopoietic stem cell transplantation10.3
25autonomic peripheral neuropathy10.3
26critical illness polyneuropathy10.3
27autonomic nervous system disease10.3
28blood protein disease10.3
29congenital nervous system abnormality10.3
30hypersensitivity reaction type iv disease10.3
31neuromuscular disease10.3
32peripheral nervous system disease10.3
33glucocorticoid therapy, response to10.2
34cryoglobulinemia10.2
35choroiditis10.2
36cerebritis10.2
37amyloidosis10.2
38engraftment syndrome10.2
39multicentric castleman disease10.2
40ureter squamous cell carcinoma10.2IL6, VEGFA
41primary gastrointestinal melanoma10.2IL6, VEGFA
42male reproductive organ benign neoplasm10.2IL6, VEGFA
43glomangioma10.2IL6, VEGFA
44protein c deficiency10.2IL6, VEGFA
45humero-ulnar synostosis10.2IL1B, IL6
46chorioamnionitis10.2IL1B, IL6
47glossopharyngeal nerve disease10.2IL1B, IL6
48hyperthyroxinemia10.2IL1B, IL6
49transient refractive change10.2IL1B, IL6
50vaginal glandular tumor10.2IL1B, IL6

Graphical network of the top 20 diseases related to Poems Syndrome:



Diseases related to poems syndrome

Symptoms for Poems Syndrome

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Symptoms:

 51 (show all 23)
  • thick skin/pachydermia/orange skin
  • irregular/in bands/reticular skin hyperpigmentation
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • lymphadenopathy/polyadenopathies
  • hypothalamic-hypophyseal axis functional anomalies/hypopituitarism
  • nerve conduction abnormality
  • agammaglobulinemia/hypogammaglobulinemia/b-cell deficiency
  • gynecomastia/breast/mammary gland enlargement/hyperplasia
  • hirsutism/hypertrichosis/increased body hair
  • arteriovenous malformations/vascular malformations (excluding port-wine stains)
  • lymphedema
  • hypothyroidy
  • insulin-independent/type 2 diabetes
  • late puberty/hypogonadism/hypogenitalism
  • precocious menopause/secondary amenorrhea
  • osteosclerosis/osteopetrosis/bone condensation
  • bone/osseous neoplasm/tumor/carcinoma/cancer
  • tapered fingers
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • decreased body hair/axillar/pubic hairlessness
  • renal disease/nephropathy
  • cortico-adrenal hypoplasia/insufficiency

HPO human phenotypes related to Poems Syndrome:

(show all 20)
id Description Frequency HPO Source Accession
1 decreased nerve conduction velocity hallmark (90%) HP:0000762
2 anterior hypopituitarism hallmark (90%) HP:0000830
3 thickened skin hallmark (90%) HP:0001072
4 splenomegaly hallmark (90%) HP:0001744
5 hepatomegaly hallmark (90%) HP:0002240
6 lymphadenopathy hallmark (90%) HP:0002716
7 decreased antibody level in blood hallmark (90%) HP:0004313
8 irregular hyperpigmentation hallmark (90%) HP:0007400
9 gynecomastia typical (50%) HP:0000771
10 hypothyroidism typical (50%) HP:0000821
11 secondary amenorrhea typical (50%) HP:0000869
12 hypertrichosis typical (50%) HP:0000998
13 lymphedema typical (50%) HP:0001004
14 type ii diabetes mellitus typical (50%) HP:0005978
15 neoplasm of the skeletal system typical (50%) HP:0010622
16 increased bone mineral density typical (50%) HP:0011001
17 arteriovenous malformation typical (50%) HP:0100026
18 nephropathy occasional (7.5%) HP:0000112
19 tapered finger occasional (7.5%) HP:0001182
20 primary adrenal insufficiency occasional (7.5%) HP:0008207

Drugs & Therapeutics for Poems Syndrome

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Drugs for Poems Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Pioglitazoneapproved, investigationalPhase 2405111025-46-84829
Synonyms:
(+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+/-)-5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione
(+/-)-5-[p-[2-(ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione
105355-27-9
111025-46-8
198077-89-3
2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]- (9CI)
5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione
5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
5-[[4-[2-[(5-ethyl-2-pyridyl)]ethoxy]phenyl]methyl]thiazolidine- 2,4-dione
5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
AB1004597
AC-1021
AC1L1J1Q
AD 4833
AD-4833
Actos
Actos (TN)
Actost
BRD-A48430263-003-02-4
BSPBio_002723
C07675
C19H20N2O3S
CHEBI:8228
CHEMBL595
CID4829
D08378
DB01132
Duetact
Glustin
HMS2089H14
HS-0047
 
HSDB 7322
I06-0089
KBio2_002103
KBio2_004671
KBio2_007239
KBio3_001943
KBioGR_001619
KBioSS_002103
LS-151327
MolPort-002-508-211
NCGC00163128-01
NCGC00163128-02
Pioglitazona
Pioglitazona [INN-Spanish]
Pioglitazone
Pioglitazone HCl
Pioglitazone Hydrochloride
Pioglitazone [BAN:INN]
Pioglitazone [Ban:Inn]
Pioglitazone [INN:BAN]
Pioglitazonum
Pioglitazonum [INN-Latin]
SPBio_001897
Spectrum2_001679
Spectrum3_001002
Spectrum4_001130
Spectrum5_001480
Spectrum5_002067
Spectrum_001623
U 72107
U 72107A
U-72107
U72,107A
UNII-X4OV71U42S
Zactos
nchembio790-comp10
pioglitazone (INN)
pioglitazone HCl
2
LenalidomideapprovedPhase 2652191732-72-6216326
Synonyms:
1-oxo-2-(2,6-Dioxopiperidin-3-yl)-4-aminoisoindoline
191732-72-6
3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione
3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
346670-73-3
443912-14-9
AC-914
AC1L50II
AKOS005146276
ALBB-015321
Bio-0168
C467567
CC 5013
CC-5013
CC-5013, Revlimid, Lenalidomide
CC5013
CDC 501
CDC-501
CDC-5013
CHEMBL848
CID216326
Celgene brand of lenalidomide
 
D04687
DB00480
EC-000.2340
ENMD-0997
I06-0831
IMID-1
IMID-5013
IMiD3
IMiD3 cpd
IMid-1
LS-184040
Lenalidomide
Lenalidomide (USAN/INN)
Lenalidomide [USAN]
MolPort-003-848-370
NCGC00167491-01
NSC747972
Revamid
Revimid
Revlimid
Revlimid (Celgene)
Revlimid (TN)
S1029_Selleck
STK639603
Thalidomide analog CC-5013
UNII-F0P408N6V4
3
Dexamethasoneapproved, investigationalPhase 2180650-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Baycadron
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
Dexameth
Dexamethansone
 
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone acetate
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone sodium phosphate
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamethsone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
Ozurdex
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
4Insulin, Globin ZincPhase 24069
5insulinPhase 24069
6Dexamethasone acetatePhase 218061177-87-3
7Dexamethasone 21-phosphatePhase 21806
8BB 1101Phase 21848
9Cephalosporins84

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pioglitazone Or Exercise to Treat Mild Cognitive Impairment (MCI)CompletedNCT00736996Phase 2
2POEMS Syndrome Treatment With LenalidomideRecruitingNCT01639898Phase 2
3The Treatment of Lenalidomide in Patients With POEMS SyndromeRecruitingNCT00971685Phase 2
4Efficacy and Safety of Lenalidomide as a Treatment for Recurrent or Refractory POEMS Syndrome TrialRecruitingNCT02193698Phase 2
5Study to Evaluate Lenalidomide Plus Dexamethasone in Patients With Newly Diagnosed POEMS SyndromeActive, not recruitingNCT01816620Phase 2
6Prospective Observational Epidemiologic Study of Maraviroc's SafetyActive, not recruitingNCT00665561
7Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for AchalasiaActive, not recruitingNCT01750385

Search NIH Clinical Center for Poems Syndrome


Cochrane evidence based reviews: POEMS Syndrome

Genetic Tests for Poems Syndrome

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Anatomical Context for Poems Syndrome

About this section

MalaCards organs/tissues related to Poems Syndrome:

33
Skin, Bone, Liver, Lymph node, Spleen, Endothelial, B cells

Animal Models for Poems Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Poems Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1IL1B, IL6, TIMP1, TNF, VEGFA
2MP:00053857.6EPO, IL1B, IL6, TIMP1, TNF, VEGFA
3MP:00053977.6EPO, IL1B, IL6, TIMP1, TNF, VEGFA
4MP:00053767.3EPO, IL1B, IL6, TIMP1, TNF, VEGFA

Publications for Poems Syndrome

About this section

Articles related to Poems Syndrome:

(show top 50)    (show all 477)
idTitleAuthorsYear
1
Altered axonal excitability properties and nerve edema in POEMS syndrome. (25735476)
2015
2
POEMS syndrome - A case report revealing a complex evolving diagnosis. (25678977)
2015
3
Pentraxin-3 and VEGF in POEMS syndrome: a 2-year longitudinal study. (25447599)
2014
4
Computed tomography assessment of bone lesions in patients with POEMS syndrome. (25253619)
2014
5
Correlation between serum level of vascular endothelial growth factor and subfoveal choroidal thickness in patients with POEMS syndrome. (25367833)
2014
6
The characteristics of ascites in patients with POEMS syndrome. (23811954)
2013
7
Outcomes of patients with POEMS syndrome treated initially with radiation. (23699599)
2013
8
POEMS syndrome and Castleman disease. (24006526)
2013
9
POEMS syndrome presenting with acute demyelinating polyneuropathy: increased terminal latency indices and uniform demyelination. (23812201)
2013
10
Glomeruloid hemangiomas in the absence of POEMS syndrome. (22443389)
2012
11
Hemangioma in POEMS syndrome: an atypical clinical and histological presentation. (21749469)
2012
12
POEMS syndrome with prominent acute axonal lesions. (21982617)
2012
13
Comparison of imaging methods in POEMS syndrome. (22580861)
2012
14
Mobilization of PBSCs in poor mobilizers with POEMS syndrome using G-CSF with plerixafor. (22609884)
2012
15
The clinical study of POEMS syndrome in China. (20424579)
2010
16
Crow-Fukase (POEMS) syndrome]. (20420180)
2010
17
POEMS syndrome, congestive heart failure and thalidomide -food for thought. (20823658)
2010
18
A case of POEMS syndrome with mixed hyaline vascular and plasma cell type Castleman's disease. (19670555)
2009
19
POEMS syndrome with an isolated lytic lesion and glomeruloid hemangiomas: report of one case]. (19701559)
2009
20
POEMS syndrome: a case report. (19119489)
2008
21
Endocrinopathy in POEMS syndrome: the Mayo Clinic experience. (17605964)
2007
22
A case of POEMS syndrome with cystoid macular edema. (15767082)
2005
23
Polyneuropathy in POEMS syndrome: role of angiogenic factors in the pathogenesis. (15975949)
2005
24
Restricted use of Vlambda genes in POEMS syndrome. (15075094)
2004
25
Thalidomide in POEMS syndrome: case report. (15114600)
2004
26
POEMS syndrome, fibrinogen, and ischemic stroke: a critical point of view. (14732636)
2004
27
POEMS syndrome. (14715103)
2003
28
Long-term follow-up on a patient with incomplete POEMS syndrome undergoing high-dose therapy and autologous blood stem cell transplantation. (12360984)
2002
29
POEMS syndrome: a case report and discussion. (11378655)
2001
30
Glomeruloid haemangioma and POEMS syndrome. (11572909)
2001
31
Pulmonary hypertension in POEMS syndrome: a new feature mediated by cytokines. (9517610)
1998
32
Abnormal FSH hypersecretion as an endocrinological manifestation of POEMS syndrome. (9625458)
1998
33
Long term melphalan-prednisolone chemotherapy for POEMS syndrome. (9328260)
1997
34
Myeloneuropathy in POEMS syndrome. (8941279)
1996
35
Acute arterial obliteration: a new feature of the POEMS syndrome? (8699962)
1996
36
Pro-inflammatory cytokines: a pathogenic key of POEMS syndrome]. (8881441)
1996
37
Amyotrophic lateral sclerosis associated with multiple myeloma, endocrinopathy and skin changes suggestive of a POEMS syndrome variant. (7595623)
1995
38
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995
39
POEMS syndrome in a female Italian patient. A case report. (8539476)
1995
40
POEMS syndrome: clinical, pathological and immunological study of a case. (7708142)
1994
41
Alopecia as a rare cutaneous manifestation of POEMS syndrome. (7918001)
1994
42
Castleman disease in POEMS syndrome with elevated interleukin-6. (8499003)
1993
43
POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report. (1953537)
1991
44
Renal involvement in POEMS syndrome. (1944731)
1991
45
POEMS syndrome with idiopathic flushing mimicking carcinoid syndrome. (2029023)
1991
46
POEMS syndrome: a rarely diagnosed multisystem disorder. (2163715)
1990
47
The endocrinopathy of POEMS syndrome. (2555917)
1989
48
Refractory ascites due to POEMS syndrome. (2535829)
1989
49
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
50
Renal ultrasound in POEMS syndrome. (3920286)
1985

Variations for Poems Syndrome

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Expression for genes affiliated with Poems Syndrome

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Search GEO for disease gene expression data for Poems Syndrome.

Pathways for genes affiliated with Poems Syndrome

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Pathways related to Poems Syndrome according to GeneCards Suite gene sharing:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL6, VEGFA
29.6IL1B, IL6
39.6IL1B, IL6
49.6TIMP1, VEGFA
5
Show member pathways
9.6TIMP1, VEGFA
69.5IL6, TNF
79.5IL1B, TNF
8
Show member pathways
9.5IL1B, TNF
99.5IL1B, TNF
109.3EPO, TIMP1
119.2IL6, TNF, VEGFA
129.2IL6, TNF, VEGFA
13
Show member pathways
9.2IL6, TIMP1, VEGFA
14
Show member pathways
9.1IL1B, IL6, TNF
159.1IL1B, IL6, TNF
16
Show member pathways
9.1IL1B, IL6, TNF
17
Show member pathways
9.1IL1B, IL6, TNF
189.1IL1B, IL6, TNF
199.1IL1B, IL6, TNF
20
Show member pathways
9.1IL1B, IL6, TNF
219.1IL1B, IL6, TNF
229.1IL1B, IL6, TNF
239.1IL1B, IL6, TNF
24
Show member pathways
9.1IL1B, IL6, TNF
259.1IL1B, IL6, TNF
269.1IL1B, IL6, TNF
279.1IL1B, IL6, TNF
28
Show member pathways
9.1IL1B, IL6, TNF
299.1IL1B, IL6, TNF
309.1IL1B, IL6, TNF
319.0EPO, TIMP1, VEGFA
32
Show member pathways
9.0EPO, TIMP1, VEGFA
339.0EPO, TIMP1, VEGFA
349.0EPO, TIMP1, VEGFA
35
Show member pathways
8.9EPO, IL6, TIMP1
368.7IL1B, IL6, TNF, VEGFA
378.7IL1B, IL6, TNF, VEGFA
38
Show member pathways
8.6IL1B, IL6, TIMP1, TNF
39
Show member pathways
8.6IL1B, IL6, TIMP1, TNF
408.5EPO, IL6, TIMP1, VEGFA
41
Show member pathways
8.5EPO, IL6, TIMP1, VEGFA
428.5EPO, IL6, TIMP1, VEGFA
437.9EPO, IL1B, IL6, TIMP1, TNF
44
Show member pathways
7.6EPO, IL1B, IL6, TIMP1, TNF, VEGFA
45
Show member pathways
7.6EPO, IL1B, IL6, TIMP1, TNF, VEGFA

GO Terms for genes affiliated with Poems Syndrome

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Cellular components related to Poems Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:003109310.1TIMP1, VEGFA
2extracellular spaceGO:00056157.6EPO, IL1B, IL6, TIMP1, TNF, VEGFA
3extracellular regionGO:00055767.3EPO, IL1B, IL6, TIMP1, TNF, VEGFA

Biological processes related to Poems Syndrome according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:003094910.3IL1B, VEGFA
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.3IL6, TNF
3positive regulation of protein complex assemblyGO:003133410.3TNF, VEGFA
4negative regulation of lipid storageGO:001088810.2IL6, TNF
5sequestering of triglycerideGO:003073010.2IL1B, TNF
6positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IL1B, TNF
7regulation of establishment of endothelial barrierGO:190314010.2IL1B, TNF
8positive regulation of chemokine productionGO:003272210.2IL6, TNF
9chronic inflammatory response to antigenic stimulusGO:000243910.2IL1B, TNF
10negative regulation of fat cell differentiationGO:004559910.2IL6, TNF
11positive regulation of chemokine biosynthetic processGO:004508010.2IL1B, TNF
12positive regulation of membrane protein ectodomain proteolysisGO:005104410.2IL1B, TNF
13negative regulation of lipid catabolic processGO:005099510.1IL1B, TNF
14positive regulation of JUN kinase activityGO:004350710.1IL1B, TNF
15positive regulation of interferon-gamma productionGO:003272910.1IL1B, TNF
16positive regulation of heterotypic cell-cell adhesionGO:003411610.1IL1B, TNF
17positive regulation of NF-kappaB import into nucleusGO:004234610.1IL1B, TNF
18regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:006141810.1EPO, VEGFA
19positive regulation of fever generationGO:003162210.1IL1B, TNF
20lipopolysaccharide-mediated signaling pathwayGO:003166310.1IL1B, TNF
21protein kinase B signalingGO:004349110.1IL1B, TNF
22positive regulation of interleukin-8 productionGO:003275710.1IL1B, TNF
23regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.0IL1B, TNF
24positive regulation of cell adhesionGO:004578510.0TNF, VEGFA
25response to electrical stimulusGO:005160210.0EPO, IL6
26positive regulation of phagocytosisGO:00507669.9IL1B, TNF
27response to salt stressGO:00096519.9EPO, TNF
28positive regulation of DNA replicationGO:00457409.8EPO, IL6
29embryo implantationGO:00075669.8EPO, IL1B
30negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.7IL1B, TNF
31positive regulation of peptidyl-serine phosphorylationGO:00331389.7IL6, TNF, VEGFA
32positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.7IL1B, IL6, TNF
33positive regulation of NF-kappaB transcription factor activityGO:00510929.6IL1B, IL6, TNF
34positive regulation of protein phosphorylationGO:00019349.6IL1B, TNF, VEGFA
35response to glucocorticoidGO:00513849.6IL1B, IL6, TNF
36cellular response to lipopolysaccharideGO:00712229.5IL1B, IL6, TNF
37positive regulation of interleukin-6 productionGO:00327559.5IL1B, IL6, TNF
38positive regulation of apoptotic processGO:00430659.5IL1B, IL6, TNF
39positive regulation of nitric oxide biosynthetic processGO:00454299.5IL1B, IL6, TNF
40response to lipopolysaccharideGO:00324969.4EPO, IL1B, IL6
41response to hypoxiaGO:00016669.3EPO, IL1B, VEGFA
42wound healingGO:00420609.3IL1B, IL6, TIMP1
43positive regulation of ERK1 and ERK2 cascadeGO:00703749.0IL1B, IL6, TNF, VEGFA
44positive regulation of gene expressionGO:00106289.0IL1B, IL6, TNF, VEGFA
45negative regulation of apoptotic processGO:00430668.9EPO, IL6, TIMP1, VEGFA
46positive regulation of cell proliferationGO:00082848.9EPO, IL6, TIMP1, VEGFA
47platelet activationGO:00301688.9IL6, TIMP1, VEGFA
48positive regulation of transcription, DNA-templatedGO:00458938.8EPO, IL1B, IL6, TNF
49agingGO:00075688.7EPO, IL1B, IL6, TIMP1
50negative regulation of transcription from RNA polymerase II promoterGO:00001228.5EPO, IL1B, TNF, VEGFA

Molecular functions related to Poems Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.2IL6, TIMP1, VEGFA
2cytokine activityGO:00051258.2IL1B, IL6, TIMP1, TNF, VEGFA

Sources for Poems Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet