MCID: PMS001
MIFTS: 56

Poems Syndrome malady

Categories: Rare diseases, Neuronal diseases, Blood diseases, Immune diseases, Skin diseases, Bone diseases

Aliases & Classifications for Poems Syndrome

About this section
Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 48Novoseek, 37MeSH, 66UMLS, 43NCIt, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Poems Syndrome:

Name: Poems Syndrome 11 46 13 52 48 37 66
Osteosclerotic Myeloma 52 66
Crow-Fukase Syndrome 46 52
Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome 46
 
Polyneuropathy-Endocrinopathy-Plasma Cell Dyscrasia Syndrome 52
Polyneuropathy Organomegaly 46
Takatsuki Syndrome 52
Pep Syndrome 52

Characteristics:

Orphanet epidemiological data:

52
poems syndrome:
Age of onset: Adult,Elderly; Age of death: adult,elderly,normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:14039
MeSH37 D016878
NCIt43 C80303
Orphanet52 ORPHA2905
SNOMED-CT60 79268002
ICD10 via Orphanet29 D47.7
MESH via Orphanet38 D016878
UMLS via Orphanet67 C0085404, C1510415

Summaries for Poems Syndrome

About this section
NIH Rare Diseases:46 Poems syndrome is a rare, mulitisystem disorder. poems stands for the disorder's features, which may include polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. signs and symptoms may include progressive sensorimotor polyneuropathy; enlarged liver, spleen, and/or lymph nodes; a disorder of the endocrine glands (often with multiple abnormalities); a monoclonal plasma cell proliferative disorder; and darkening of the skin (hyperpigmentation). various other symptoms may also occur and may vary among affected people. the underlying cause of the disorder is not well understood. poems syndrome is a chronic disorder, with a median survival time of 8-14 years. there is no standard treatment; management depends on the underlying plasma cell disorder and may include radiation therapy, chemotherapy, and/or hematopoietic cell transplantation. last updated: 7/20/2015

MalaCards based summary: Poems Syndrome, also known as osteosclerotic myeloma, is related to pulmonary hypertension and alopecia, and has symptoms including decreased nerve conduction velocity, anterior hypopituitarism and thickened skin. An important gene associated with Poems Syndrome is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways are Signaling events mediated by TCPTP and Prion diseases. Affiliated tissues include skin, lymph node and liver, and related mouse phenotypes are neoplasm and liver/biliary system.

Wikipedia:69 POEMS syndrome (also known as Crow–Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare... more...

Related Diseases for Poems Syndrome

About this section

Diseases related to Poems Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 360)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary hypertension30.8IL1B, TNF
2alopecia30.0IL6, TNF
3cryoglobulinemia29.7IL1B, IL6, TNF
4sinusitis29.7IL1B, TNF
5myocardial infarction29.0IL1B, IL6, TNF, VEGFA
6lateral sclerosis28.9IL1B, IL6, TNF, VEGFA
7rheumatoid arthritis28.8IL1B, IL6, TNF, VEGFA
8kidney sarcoma10.6IL6, VEGFA
9amelogenesis imperfecta hypomaturation type10.6IL6, VEGFA
10labia minora cancer10.6IL6, VEGFA
11cyclothymic disorder10.6IL6, VEGFA
12histoplasmosis10.6IL6, VEGFA
13hereditary renal cell carcinoma10.6IL6, VEGFA
14gasserian ganglion meningioma10.6IL6, VEGFA
15marchiafava bignami disease10.6IL6, VEGFA
16thrombophilia10.5IL6, VEGFA
17corneal deposit10.5IL1B, IL6
18tarsal tunnel syndrome10.5IL1B, IL6
19speech disorder10.5IL6, VEGFA
20midline interhemispheric variant of holoprosencephaly10.5IL1B, IL6
21hemoglobinopathy10.5IL1B, IL6
22melorheostosis10.5IL1B, IL6
23infancy electroclinical syndrome10.5IL1B, IL6
24cutaneous liposarcoma10.5MYOM2, VEGFA
25sacrococcygeal teratoma10.5IL6, VEGFA
26angiosarcoma10.5HGF, VEGFA
27conventional leiomyosarcoma10.5IL1B, IL6
28naegeli-franceschetti-jadassohn syndrome/dermatopathia pigmentosa reticularis10.5IL1B, VEGFA
29spinal cord astrocytoma10.5MYOM2, VEGFA
30colorectal adenoma10.5HGF, VEGFA
31subglottis neoplasm10.5IL1B, IL6
32lung occult adenocarcinoma10.5IL1B, IL6
33bladder neck cancer10.5IL6, VEGFA
34saethre-chotzen syndrome10.5HGF, IL6
35inflammatory spondylopathy10.5IL1B, IL6
36syphilitic encephalitis10.5IL1B, IL6
37ocular cancer10.5IL1B, IL6
38periodic paralyses10.5IL1B, IL6
39polyneuropathy10.5
40ischemic heart disease10.5IL6, VEGFA
41sarcoidosis, early-onset10.5HGF, IL6
42human monocytic ehrlichiosis10.5IL1B, IL6
43philophthalmiasis10.5IL1B, IL6
44solitary osseous plasmacytoma10.5IL6, MYOM2
45ulcerative colitis10.5IL1B, IL6
46kaposi sarcoma10.4HGF, IL6
47renal artery disease10.4IL1B, IL6
48echinococcosis10.4IL1B, IL6
49bullous pemphigoid10.4IL6, MYOM2
50substernal goiter10.4HGF, IL6

Graphical network of the top 20 diseases related to Poems Syndrome:



Diseases related to poems syndrome

Symptoms for Poems Syndrome

About this section

HPO human phenotypes related to Poems Syndrome:

(show all 20)
id Description Frequency HPO Source Accession
1 decreased nerve conduction velocity hallmark (90%) HP:0000762
2 anterior hypopituitarism hallmark (90%) HP:0000830
3 thickened skin hallmark (90%) HP:0001072
4 splenomegaly hallmark (90%) HP:0001744
5 hepatomegaly hallmark (90%) HP:0002240
6 lymphadenopathy hallmark (90%) HP:0002716
7 decreased antibody level in blood hallmark (90%) HP:0004313
8 irregular hyperpigmentation hallmark (90%) HP:0007400
9 gynecomastia typical (50%) HP:0000771
10 hypothyroidism typical (50%) HP:0000821
11 secondary amenorrhea typical (50%) HP:0000869
12 hypertrichosis typical (50%) HP:0000998
13 lymphedema typical (50%) HP:0001004
14 type ii diabetes mellitus typical (50%) HP:0005978
15 neoplasm of the skeletal system typical (50%) HP:0010622
16 increased bone mineral density typical (50%) HP:0011001
17 arteriovenous malformation typical (50%) HP:0100026
18 nephropathy occasional (7.5%) HP:0000112
19 tapered finger occasional (7.5%) HP:0001182
20 primary adrenal insufficiency occasional (7.5%) HP:0008207

Drugs & Therapeutics for Poems Syndrome

About this section

Drugs for Poems Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ThalidomidePhase 2106050-35-15426
Synonyms:
( inverted question mark)-Thalidomide
(+)-Thalidomide
(+-)-N-(2,6-dioxo-3-Piperidyl)phthalimide
(+-)-Thalidomide
(+/-)-THALIDOMIDE
(?)-Thalidomide
(±)-N-(2,6-dioxo-3-piperidyl)phthalimide
(±)-thalidomide
.alpha.-(N-Phthalimido)glutarimide
.alpha.-N-Phthalylglutaramide
.alpha.-Phthalimidoglutarimide
1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline
14088-68-7
2,6-Dioxo-3-phthalimidopiperidine
2,6-dioxo-3-phthalimidopiperidine
3-Phthalimidoglutarimide
50-35-1
731-40-8
AB00052362
AC-917
AC1L1KBZ
AC1Q6FJA
AI3-50606
Algosediv
Asidon 3
Asmadion
Asmaval
BPBio1_000159
BRD-A93255169-001-06-9
BRN 0030233
BSPBio_000143
BSPBio_001156
BSPBio_003330
Bio1_000387
Bio1_000876
Bio1_001365
Bio2_000418
Bio2_000898
Bonbrain
Bonbrrin
C07910
C13H10N2O4
CCRIS 8148
CHEBI:105028
CHEMBL468
CID5426
CPD000058524
Calmore
Calmorex
Celgene Brand of Thalidomide
Contergan
Corronarobetin
D00754
D013792
DB01041
Distaval
Distaxal
Distoval
DivK1c_000051
E-217
EINECS 200-031-1
ENMD 0995
EU-0101224
Ectiluran
Enterosediv
Gastrinide
Glupan
Glutanon
Grippex
HMS1362J17
HMS1568H05
HMS1792J17
HMS1922E12
HMS1990J17
HMS2090O05
HMS2093G15
HMS500C13
HSDB 3586
Hippuzon
I06-0197
IDI1_000051
IDI1_002173
IN1061
Imida-Lab
Imida-lab
Imidan
Imidan (peyta)
Imidene
Isomin
K 17
K-17
KBio1_000051
KBio2_000496
KBio2_002322
KBio2_003064
KBio2_004890
KBio2_005632
KBio2_007458
KBio3_000911
KBio3_000912
KBio3_002550
KBio3_002802
KBioGR_000496
KBioGR_001474
KBioGR_002322
KBioSS_000496
KBioSS_002324
Kedavon
Kevadon
LS-109463
LS-140
Lopac0_001224
Lulamin
MLS000069353
MolPort-003-665-582
N-(2,6-Dioxo-3-piperidyl)phthalimide
N-(2,6-dioxo-3-piperidyl)phthalimide
N-Phthalimidoglutamic acid imide
N-Phthaloylglutamimide
N-Phthalyl-glutaminsaeure-imid
N-Phthalyl-glutaminsaeure-imid [German]
N-Phthalylglutamic acid imide
NCGC00015989-03
NCGC00015989-13
NCGC00024708-02
 
NCGC00024708-03
NCGC00024708-04
NCGC00024708-05
NCGC00024708-06
NCGC00024708-07
NCGC00024708-08
NCGC00024708-09
NCI60_023904
NCIOpen2_003188
NINDS_000051
NSC 527179
NSC-66847
NSC527179
NSC66847
NSC91729
NSC91730
Neaufatin
Neo
Neosedyn
Neosydyn
Nerosedyn
Neufatin
Neurodyn
Neurosedin
Neurosedym
Neurosedyn
Nevrodyn
Nibrol
Noctosediv
Noxodyn
Pangul
Pantosediv
Poly-Giron
Polygripan
Predni-Sediv
Prestwick0_000192
Prestwick1_000192
Prestwick2_000192
Prestwick3_000192
Prestwick_463
Pro-Bam M
Pro-ban M
Profarmil
Psycholiquid
Psychotablets
Quetimid
Quietoplex
S1193_Selleck
SAM002564245
SMR000058524
SPBio_000893
SPBio_002064
SPECTRUM1503607
ST51039042
Sandormin
Sedalis
Sedalis sedi-lab
Sedimide
Sedin
Sedisperil
Sedoval
Shin-naito S
Shinnibrol
Sleepan
Slipro
Softenil
Softenon
Spectrum2_000707
Spectrum3_001715
Spectrum4_001087
Spectrum5_001791
Synovir
T144_SIGMA
T150_SIGMA
T151_SIGMA
THALIDOMIDE (AIDS INITIATIVE)
Talargan
Talidomida
Talidomida [INN-Spanish]
Talidomide
Talidomide [DCIT]
Talimol
Talismol
Talizer
Telagan
Telargan
Telargean
Tensival
Thaled
Thaled (TN)
Thalidomide
Thalidomide (+ and -)
Thalidomide (JAN/USP/INN)
Thalidomide (soluble form)
Thalidomide Celgene
Thalidomide Pharmion
Thalidomide [USAN:INN:BAN]
Thalidomidum
Thalidomidum [INN-Latin]
Thalidomine USP26
Thalin
Thalinette
Thalomid
Thalomid (TM)
Thalomid (TN)
Thalomid, Thalidomide
Thalomide
Theophilcholine
UNII-4Z8R6ORS6L
UPCMLD-DP139
UPCMLD-DP139:001
Valgis
Valgraine
WLN: T56 BVNVJ C- DT6VMVTJ
WLN: T56 BVNVJ C- DT6VMVTJ -D
WLN: T56 BVNVJ C- DT6VMVTJ -L
Yodomin
alpha-(N-Phthalimido)glutarimide
alpha-N-Phthalylglutaramide
alpha-Phthalimidoglutarimide
alpha-phthalimidoglutarimide
cMAP_000022
thalidomide
α-(N-phthalimido)glutarimide
α-N-phthalylglutaramide
α-phthalimidoglutarimide
2insulinPhase 24401
3
PioglitazonePhase 2428111025-46-84829
Synonyms:
(+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+/-)-5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione
(+/-)-5-[p-[2-(ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione
105355-27-9
111025-46-8
198077-89-3
2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]- (9CI)
5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione
5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
5-[[4-[2-[(5-ethyl-2-pyridyl)]ethoxy]phenyl]methyl]thiazolidine- 2,4-dione
5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
AB1004597
AC-1021
AC1L1J1Q
AD 4833
AD-4833
Actos
Actos (TN)
Actost
BRD-A48430263-003-02-4
BSPBio_002723
C07675
C19H20N2O3S
CHEBI:8228
CHEMBL595
CID4829
D08378
DB01132
Duetact
Glustin
HMS2089H14
HS-0047
 
HSDB 7322
I06-0089
KBio2_002103
KBio2_004671
KBio2_007239
KBio3_001943
KBioGR_001619
KBioSS_002103
LS-151327
MolPort-002-508-211
NCGC00163128-01
NCGC00163128-02
Pioglitazona
Pioglitazona [INN-Spanish]
Pioglitazone
Pioglitazone HCl
Pioglitazone Hydrochloride
Pioglitazone [BAN:INN]
Pioglitazone [Ban:Inn]
Pioglitazone [INN:BAN]
Pioglitazonum
Pioglitazonum [INN-Latin]
SPBio_001897
Spectrum2_001679
Spectrum3_001002
Spectrum4_001130
Spectrum5_001480
Spectrum5_002067
Spectrum_001623
U 72107
U 72107A
U-72107
U72,107A
UNII-X4OV71U42S
Zactos
nchembio790-comp10
pioglitazone (INN)
pioglitazone HCl
4
DexamethasonePhase 2200150-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
5
protease inhibitorsPhase 25157
Synonyms:
 
protease inhibitors
6Dexamethasone acetatePhase 220011177-87-3
7glucocorticoidsPhase 24756
8
LenalidomidePhase 2691191732-72-6216326
Synonyms:
1-oxo-2-(2,6-Dioxopiperidin-3-yl)-4-aminoisoindoline
191732-72-6
3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione
3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
346670-73-3
443912-14-9
AC-914
AC1L50II
AKOS005146276
ALBB-015321
Bio-0168
C467567
CC 5013
CC-5013
CC-5013, Revlimid, Lenalidomide
CC5013
CDC 501
CDC-501
CDC-5013
CHEMBL848
CID216326
Celgene brand of lenalidomide
D04687
 
DB00480
EC-000.2340
ENMD-0997
I06-0831
IMID-1
IMID-5013
IMiD3
IMiD3 cpd
IMid-1
LS-184040
Lenalidomide
Lenalidomide (USAN/INN)
Lenalidomide [USAN]
MolPort-003-848-370
NCGC00167491-01
NSC747972
Revamid
Revimid
Revlimid
Revlimid (Celgene)
Revlimid (TN)
S1029_Selleck
STK639603
Thalidomide analog CC-5013
UNII-F0P408N6V4
lenalidomide
9
Maraviroc139376348-65-13002977
Synonyms:
376348-65-1
4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide
4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
674782-29-7
AC-558
AC1MHEFQ
CHEBI:537583
CHEMBL1201187
CHEMBL256907
CID3002977
Celsentri
Celsentri(TM)
DB04835
Isopropyl, 4,4-difluoro-N-((1S)-3-{(1R,3s,5S)-3-(3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)octan-8-yl}-1-phenylpropyl)cyclohexanecarboxamide
 
LS-182818
MVC
Maraviroc
Maraviroc [USAN]
PRO 140 & Maraviroc
PRO 140 (Anti-CCR5 monoclonal antibody) & exo-4,4-Difluoro-N-[3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1(S)-phenylpropyl]cyclohexanecarboxamide
Selzentry
Selzentry(TM)
UK 427857
UK-427,857
UK-427,857 maraviroc (MVC)
UK-427857
UNII-MD6P741W8A
exo-4,4-Difluoro-N-[3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1(S)-phenylpropyl]cyclohexanecarboxamide
maraviroc

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Safety of Lenalidomide as a Treatment for Recurrent or Refractory POEMS Syndrome TrialCompletedNCT02193698Phase 2
2Pioglitazone Or Exercise to Treat Mild Cognitive Impairment (MCI)CompletedNCT00736996Phase 2
3POEMS Syndrome Treatment With LenalidomideRecruitingNCT01639898Phase 2
4The Treatment of Lenalidomide in Patients With POEMS SyndromeRecruitingNCT00971685Phase 2
5Study to Evaluate Lenalidomide Plus Dexamethasone in Patients With Newly Diagnosed POEMS SyndromeActive, not recruitingNCT01816620Phase 2
6Prospective Observational Epidemiologic Study of Maraviroc's SafetyActive, not recruitingNCT00665561
7Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for AchalasiaActive, not recruitingNCT01750385
8Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS SyndromeNot yet recruitingNCT02921893

Search NIH Clinical Center for Poems Syndrome


Cochrane evidence based reviews: poems syndrome

Genetic Tests for Poems Syndrome

About this section

Anatomical Context for Poems Syndrome

About this section

MalaCards organs/tissues related to Poems Syndrome:

34
Skin, Lymph node, Liver, Spleen, Endothelial, Bone, Heart

Animal Models for Poems Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Poems Syndrome:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6IL1B, IL6, TNF, VEGFA
2MP:00053708.0CD36, HGF, IL6, TNF, VEGFA
3MP:00053907.7CD36, IL1B, IL6, TNF, VEGFA
4MP:00053977.2CD36, HGF, IL1B, IL6, TNF, VEGFA
5MP:00053856.9CD36, HGF, IL1B, IL6, TNF, VEGFA

Publications for Poems Syndrome

About this section

Articles related to Poems Syndrome:

(show top 50)    (show all 515)
idTitleAuthorsYear
1
Long-term outcome of patients with POEMS syndrome: An update of the Mayo Clinic experience. (26972803)
2016
2
POEMS Syndrome: A Rare Disease With A Challenging Diagnosis. (26742203)
2015
3
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) treated with autologous hematopoietic stem cell transplantation: a case report and literature review. (25726020)
2015
4
Cutaneous Manifestations in POEMS Syndrome: Case Report and Review. (26034475)
2015
5
Pentraxin-3 and VEGF in POEMS syndrome: a 2-year longitudinal study. (25447599)
2014
6
Correlation between serum level of vascular endothelial growth factor and subfoveal choroidal thickness in patients with POEMS syndrome. (25367833)
2014
7
Pulmonary hypertension in POEMS syndrome: resolution following radiotherapy. (25610609)
2014
8
Lenalidomide as frontline therapy in POEMS syndrome: a retrospective case series of 8 patients. (25347429)
2014
9
Outcomes of patients with POEMS syndrome treated initially with radiation. (23699599)
2013
10
POEMS syndrome and Castleman disease. (24006526)
2013
11
Bevacizumab treatment followed by maintenance in life-threatening POEMS syndrome. (23334107)
2013
12
Comparison of imaging methods in POEMS syndrome. (22580861)
2012
13
Successful treatment with bortezomib and thalidomide for POEMS syndrome associated with multicentric mixed-type Castleman's disease. (21890654)
2011
14
The clinical study of POEMS syndrome in China. (20424579)
2010
15
POEMS syndrome - a unique presentation of a rare paraneoplastic syndrome. (22798312)
2010
16
Coexistence of primary AL amyloidosis and POEMS syndrome: efficacy of melphalan-dexamethasone and role of biochemical markers in monitoring the diseases course. (20029992)
2010
17
POEMS syndrome with an isolated lytic lesion and glomeruloid hemangiomas: report of one case]. (19701559)
2009
18
Lenalidomide therapy in a rare case of POEMS syndrome with kappa restriction. (19738540)
2009
19
Spontaneous recovery of adrenal insufficiency in POEMS syndrome. (19295942)
2009
20
Discrepancy between disease activity and levels of vascular endothelial growth factor in a patient with POEMS syndrome successfully treated with autologous stem-cell transplantation. (18660839)
2008
21
New strategy of treatment for POEMS syndrome--autologous peripheral blood stem cell transplantation and thalidomide therapy]. (18567358)
2008
22
POEMS syndrome with lambda chain deposition in hemangioma. (18573727)
2008
23
VEGF and osteosclerosis in POEMS syndrome. (18172647)
2008
24
IgM-lambda paraproteinemia with associated cutaneous lymphoplasmacytic infiltrate in a patient who meets diagnostic criteria for POEMS syndrome. (18342713)
2008
25
Efficacy of autologous peripheral blood stem cell transplantation in POEMS syndrome with polyneuropathy. (17268130)
2007
26
Polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes: not always a POEMS syndrome. (16709518)
2006
27
Polyneuropathy in POEMS syndrome: role of angiogenic factors in the pathogenesis. (15975949)
2005
28
Thalidomide in POEMS syndrome: case report. (15114600)
2004
29
Crow-Fukase (POEMS) syndrome: a study of peripheral nerve biopsy in five new cases. (12904234)
2003
30
Long-term follow-up on a patient with incomplete POEMS syndrome undergoing high-dose therapy and autologous blood stem cell transplantation. (12360984)
2002
31
Reversible pulmonary hypertension in POEMS syndrome--another etiology of triggered pulmonary vasculopathy? (10978936)
2000
32
Abnormal FSH hypersecretion as an endocrinological manifestation of POEMS syndrome. (9625458)
1998
33
Long term melphalan-prednisolone chemotherapy for POEMS syndrome. (9328260)
1997
34
Pro-inflammatory cytokines: a pathogenic key of POEMS syndrome]. (8881441)
1996
35
Greatly raised vascular endothelial growth factor (VEGF) in POEMS syndrome. (8596427)
1996
36
Poor response to intravenous immunoglobulin therapy in patients with Castleman's disease and the POEMS syndrome. (8923307)
1996
37
Amyotrophic lateral sclerosis associated with multiple myeloma, endocrinopathy and skin changes suggestive of a POEMS syndrome variant. (7595623)
1995
38
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995
39
POEMS syndrome: clinical, pathological and immunological study of a case. (7708142)
1994
40
Alopecia as a rare cutaneous manifestation of POEMS syndrome. (7918001)
1994
41
Angioendotheliomatosis associated with Castleman's lymphoma and POEMS syndrome. (8403477)
1993
42
POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report. (1953537)
1991
43
Renal involvement in POEMS syndrome. (1944731)
1991
44
POEMS syndrome: an Italian case with diagnostic and therapeutic implications. (1804287)
1991
45
The kidney disease of Crow-Fukase (POEMS) syndrome: a clinico-pathological study of four cases. (1934663)
1991
46
Premature vascular calcification in a case of POEMS syndrome. (1756747)
1991
47
The endocrinopathy of POEMS syndrome. (2555917)
1989
48
Refractory ascites due to POEMS syndrome. (2535829)
1989
49
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
50
POEMS syndrome presenting as systemic sclerosis. Clinical and pathologic study of a case with microangiopathic glomerular lesions. (3348253)
1988

Variations for Poems Syndrome

About this section

Expression for genes affiliated with Poems Syndrome

About this section
Search GEO for disease gene expression data for Poems Syndrome.

Pathways for genes affiliated with Poems Syndrome

About this section

Pathways related to Poems Syndrome according to GeneCards Suite gene sharing:

(show all 41)
idSuper pathwaysScoreTop Affiliating Genes
19.6HGF, VEGFA
29.5IL1B, IL6
39.5IL1B, IL6
49.4IL6, TNF
59.3IL1B, TNF
6
Show member pathways
9.3IL1B, TNF
79.1HGF, IL6, VEGFA
89.0IL6, TNF, VEGFA
99.0HGF, TNF, VEGFA
10
Show member pathways
8.9IL1B, IL6, TNF
11
Show member pathways
8.9IL1B, IL6, TNF
128.9IL1B, IL6, TNF
13
Show member pathways
8.9IL1B, IL6, TNF
14
Show member pathways
8.9IL1B, IL6, TNF
158.9IL1B, IL6, TNF
16
Show member pathways
8.9IL1B, IL6, TNF
17
Show member pathways
8.9IL1B, IL6, TNF
18
Show member pathways
8.9IL1B, IL6, TNF
198.9IL1B, IL6, TNF
208.9IL1B, IL6, TNF
218.9IL1B, IL6, TNF
228.9IL1B, IL6, TNF
238.9IL1B, IL6, TNF
248.9IL1B, IL6, TNF
258.9IL1B, IL6, TNF
26
Show member pathways
8.9IL1B, IL6, TNF
278.9IL1B, IL6, TNF
288.9IL1B, IL6, TNF
298.6CD36, IL6, TNF
308.6CD36, IL6, TNF
318.5CD36, IL1B, TNF
328.5IL1B, IL6, TNF, VEGFA
338.5IL1B, IL6, TNF, VEGFA
348.5IL1B, IL6, TNF, VEGFA
358.4HGF, IL1B, IL6, TNF
36
Show member pathways
8.4HGF, IL1B, IL6, TNF
37
Show member pathways
8.1CD36, IL1B, IL6, TNF
388.1CD36, IL1B, IL6, TNF
39
Show member pathways
8.0HGF, IL1B, IL6, TNF, VEGFA
40
Show member pathways
7.7CD36, HGF, IL6, TNF, VEGFA
417.5CD36, HGF, IL1B, IL6, TNF

GO Terms for genes affiliated with Poems Syndrome

About this section

Cellular components related to Poems Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9CD36, IL6, TNF
2extracellular regionGO:00055767.7HGF, IL1B, IL6, TNF, VEGFA
3extracellular spaceGO:00056157.2CD36, HGF, IL1B, IL6, TNF, VEGFA

Biological processes related to Poems Syndrome according to GeneCards Suite gene sharing:

(show all 48)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:003094910.3IL1B, VEGFA
2positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.2IL6, VEGFA
3positive chemotaxisGO:005091810.1HGF, VEGFA
4positive regulation of protein complex assemblyGO:003133410.1TNF, VEGFA
5positive regulation of chemokine productionGO:003272210.1IL6, TNF
6epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.1IL6, TNF
7cellular response to hepatocyte growth factor stimulusGO:003572910.1HGF, IL6
8positive regulation of calcidiol 1-monooxygenase activityGO:006055910.0IL1B, TNF
9positive regulation of membrane protein ectodomain proteolysisGO:005104410.0IL1B, TNF
10sequestering of triglycerideGO:003073010.0IL1B, TNF
11chronic inflammatory response to antigenic stimulusGO:000243910.0IL1B, TNF
12regulation of establishment of endothelial barrierGO:190314010.0IL1B, TNF
13positive regulation of chemokine biosynthetic processGO:004508010.0IL1B, TNF
14positive regulation of NF-kappaB import into nucleusGO:004234610.0IL1B, TNF
15lipopolysaccharide-mediated signaling pathwayGO:003166310.0IL1B, TNF
16negative regulation of lipid storageGO:001088810.0IL6, TNF
17protein kinase B signalingGO:00434919.9IL1B, TNF
18positive regulation of heterotypic cell-cell adhesionGO:00341169.9IL1B, TNF
19positive regulation of fever generationGO:00316229.9IL1B, TNF
20negative regulation of lipid catabolic processGO:00509959.9IL1B, TNF
21negative regulation of interleukin-6 productionGO:00327159.9HGF, TNF
22negative regulation of fat cell differentiationGO:00455999.9IL6, TNF
23negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.9IL1B, TNF
24regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.8IL1B, TNF
25positive regulation of JUN kinase activityGO:00435079.8IL1B, TNF
26positive regulation of interleukin-8 productionGO:00327579.8IL1B, TNF
27response to stilbenoidGO:00356349.7CD36, IL1B
28positive regulation of phagocytosisGO:00507669.7IL1B, TNF
29positive regulation of blood microparticle formationGO:20003349.7CD36, TNF
30negative regulation of growth of symbiont in hostGO:00441309.6CD36, TNF
31positive regulation of angiogenesisGO:00457669.5HGF, IL1B, VEGFA
32positive regulation of protein phosphorylationGO:00019349.5IL1B, TNF, VEGFA
33positive regulation of peptidyl-serine phosphorylationGO:00331389.3IL6, TNF, VEGFA
34positive regulation of NF-kappaB transcription factor activityGO:00510929.3IL1B, IL6, TNF
35positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.3IL1B, IL6, TNF
36platelet degranulationGO:00025769.3CD36, HGF, VEGFA
37negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.3HGF, IL6, VEGFA
38positive regulation of nitric oxide biosynthetic processGO:00454299.3IL1B, IL6, TNF
39cellular response to lipopolysaccharideGO:00712229.1CD36, IL6, TNF
40positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.0CD36, IL1B, TNF
41defense response to Gram-positive bacteriumGO:00508308.9CD36, IL6, TNF
42positive regulation of peptidyl-tyrosine phosphorylationGO:00507318.8CD36, HGF, IL6, VEGFA
43activation of MAPK activityGO:00001878.8HGF, IL1B, TNF
44positive regulation of gene expressionGO:00106288.7IL1B, IL6, TNF, VEGFA
45positive regulation of interleukin-6 productionGO:00327558.5CD36, IL1B, IL6, TNF
46positive regulation of ERK1 and ERK2 cascadeGO:00703748.1CD36, IL1B, IL6, TNF
47negative regulation of transcription from RNA polymerase II promoterGO:00001228.0CD36, IL1B, TNF, VEGFA
48positive regulation of transcription from RNA polymerase II promoterGO:00459447.7HGF, IL1B, IL6, TNF, VEGFA

Molecular functions related to Poems Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:00420569.6HGF, VEGFA
2growth factor activityGO:00080839.1HGF, IL6, VEGFA
3cytokine activityGO:00051258.2IL1B, IL6, TNF, VEGFA

Sources for Poems Syndrome

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet