MCID: PMS001
MIFTS: 64

Poems Syndrome

Categories: Rare diseases, Bone diseases, Skin diseases, Neuronal diseases, Blood diseases, Immune diseases

Aliases & Classifications for Poems Syndrome

MalaCards integrated aliases for Poems Syndrome:

Name: Poems Syndrome 12 72 49 55 36 51 41 14 69
Osteosclerotic Myeloma 55 69
Crow-Fukase Syndrome 49 55
Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome 49
Polyneuropathy-Endocrinopathy-Plasma Cell Dyscrasia Syndrome 55
Polyneuropathy Organomegaly 49
Takatsuki Syndrome 55
Pep Syndrome 55

Characteristics:

Orphanet epidemiological data:

55
poems syndrome
Age of onset: Adult,Elderly; Age of death: adult,elderly,normal life expectancy;

Classifications:



Summaries for Poems Syndrome

NIH Rare Diseases : 49 POEMS syndrome is a rare, mulitisystem disorder. POEMS stands for the disorder's features, which may include Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes. Signs and symptoms may include progressive sensorimotor polyneuropathy; enlarged liver, spleen, and/or lymph nodes; a disorder of the endocrine glands (often with multiple abnormalities); a monoclonal plasma cell proliferative disorder; and darkening of the skin (hyperpigmentation). Various other symptoms may also occur and may vary among affected people. The underlying cause of the disorder is not well understood. POEMS syndrome is a chronic disorder, with a median survival time of 8-14 years. There is no standard treatment; management depends on the underlying plasma cell disorder and may include radiation therapy, chemotherapy, and/or hematopoietic cell transplantation. Last updated: 7/20/2015

MalaCards based summary : Poems Syndrome, also known as osteosclerotic myeloma, is related to glomeruloid hemangioma and macular retinal edema, and has symptoms including polyneuropathy, hypogonadism and visceromegaly. An important gene associated with Poems Syndrome is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Dexamethasone and Lenalidomide have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and liver, and related phenotypes are cardiovascular system and immune system

Wikipedia : 72 POEMS syndrome (also termed osteosclerotic myeloma, Crow–Fukase syndrome, Takatsuki disease, or PEP... more...

Related Diseases for Poems Syndrome

Diseases related to Poems Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 344)
# Related Disease Score Top Affiliating Genes
1 glomeruloid hemangioma 30.8 MYOM2 VEGFA
2 macular retinal edema 30.3 IL6 VEGFA
3 hematopoietic stem cell transplantation 30.1 IL6 TNF
4 myeloma, multiple 30.0 IL6 MYOM2 VEGFA
5 plasma cell neoplasm 29.7 IL6 MYOM2
6 pericardial effusion 29.7 IL6 VEGFA
7 osteosclerotic myeloma 29.5 IL1B IL6 MYOM2 TNF
8 arthritis 29.4 IL1B IL6 TNF
9 brucellosis 29.3 IL6 TNF
10 rheumatoid arthritis 29.0 IL1B IL6 TNF VEGFA
11 myocardial infarction 29.0 IL1B IL6 TNF VEGFA
12 end stage renal failure 28.8 EPO IL6 TNF
13 diabetes mellitus 28.8 IL1B IL6 TNF VEGFA
14 polyneuropathy 10.4
15 spinal disease 10.4 IL6 VEGFA
16 primary effusion lymphoma 10.4 IL6 VEGFA
17 central retinal vein occlusion 10.4 IL6 VEGFA
18 recurrent corneal erosion 10.4 IL1B IL6
19 bagassosis 10.4 IL1B IL6
20 periodontitis, chronic 10.3 IL1B IL6
21 uremic pruritus 10.3 IL1B IL6
22 funisitis 10.3 IL1B IL6
23 euthyroid sick syndrome 10.3 IL1B IL6
24 ascaris lumbricoides infection 10.3 IL1B IL6
25 median neuropathy 10.3 MYOM2 VEGFA
26 dupuytren contracture 10.3 IL1B VEGFA
27 diabetic macular edema 10.3 IL6 VEGFA
28 pyogenic granuloma 10.3 ANGPT2 VEGFA
29 gastroschisis 10.3 IL1B IL6
30 vaginal disease 10.3 IL1B IL6
31 nodular goiter 10.3 IL6 VEGFA
32 vaginitis 10.3 IL1B IL6
33 endometrial disease 10.3 IL1B IL6
34 background diabetic retinopathy 10.3 ANGPT2 VEGFA
35 primary amebic meningoencephalitis 10.3 IL1B IL6
36 cysticercosis 10.3 IL1B IL6
37 lipodermatosclerosis 10.3 ANGPT2 VEGFA
38 hemangioma 10.3
39 hydrarthrosis 10.3 IL1B IL6
40 polyclonal hypergammaglobulinemia 10.3 IL6 MYOM2
41 endotheliitis 10.3
42 anca-associated vasculitis 10.3 ANGPT2 IL6
43 impetigo 10.3 IL6 MYOM2
44 macular holes 10.3 ANGPT2 VEGFA
45 gingival disease 10.3 IL1B IL6
46 peripheral artery disease 10.3 IL6 VEGFA
47 necrotizing fasciitis 10.3 IL6 MYOM2
48 scorpion envenomation 10.2 IL6 TNF
49 intermittent claudication 10.2 IL6 VEGFA
50 radiation proctitis 10.2 TNF VEGFA

Graphical network of the top 20 diseases related to Poems Syndrome:



Diseases related to Poems Syndrome

Symptoms & Phenotypes for Poems Syndrome

Human phenotypes related to Poems Syndrome:

55 31 (show all 46)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 polyneuropathy 55 31 obligate (100%) Obligate (100%) HP:0001271
2 hypogonadism 55 31 hallmark (90%) Very frequent (99-80%) HP:0000135
3 visceromegaly 55 31 hallmark (90%) Very frequent (99-80%) HP:0003271
4 lymphoproliferative disorder 55 31 hallmark (90%) Very frequent (99-80%) HP:0005523
5 increased antibody level in blood 55 31 hallmark (90%) Very frequent (99-80%) HP:0010702
6 abnormality of skin physiology 55 31 hallmark (90%) Very frequent (99-80%) HP:0011122
7 gynecomastia 55 31 frequent (33%) Frequent (79-30%) HP:0000771
8 diabetes mellitus 55 31 frequent (33%) Frequent (79-30%) HP:0000819
9 hypothyroidism 55 31 frequent (33%) Frequent (79-30%) HP:0000821
10 hyperpigmentation of the skin 55 31 frequent (33%) Frequent (79-30%) HP:0000953
11 hypertrichosis 55 31 frequent (33%) Frequent (79-30%) HP:0000998
12 hemangioma 55 31 frequent (33%) Frequent (79-30%) HP:0001028
13 thickened skin 55 31 frequent (33%) Frequent (79-30%) HP:0001072
14 papilledema 55 31 frequent (33%) Frequent (79-30%) HP:0001085
15 areflexia 55 31 frequent (33%) Frequent (79-30%) HP:0001284
16 ascites 55 31 frequent (33%) Frequent (79-30%) HP:0001541
17 pericardial effusion 55 31 frequent (33%) Frequent (79-30%) HP:0001698
18 leukonychia 55 31 frequent (33%) Frequent (79-30%) HP:0001820
19 weight loss 55 31 frequent (33%) Frequent (79-30%) HP:0001824
20 thrombocytosis 55 31 frequent (33%) Frequent (79-30%) HP:0001894
21 pulmonary arterial hypertension 55 31 frequent (33%) Frequent (79-30%) HP:0002092
22 pleural effusion 55 31 frequent (33%) Frequent (79-30%) HP:0002202
23 sclerosis of skull base 55 31 frequent (33%) Frequent (79-30%) HP:0002694
24 lymphadenopathy 55 31 frequent (33%) Frequent (79-30%) HP:0002716
25 paresthesia 55 31 frequent (33%) Frequent (79-30%) HP:0003401
26 sclerosis of hand bone 55 31 frequent (33%) Frequent (79-30%) HP:0004054
27 sclerotic vertebral endplates 55 31 frequent (33%) Frequent (79-30%) HP:0004576
28 metaphyseal sclerosis 55 31 frequent (33%) Frequent (79-30%) HP:0004979
29 primary adrenal insufficiency 55 31 frequent (33%) Frequent (79-30%) HP:0008207
30 fatigue 55 31 frequent (33%) Frequent (79-30%) HP:0012378
31 pain 55 31 frequent (33%) Frequent (79-30%) HP:0012531
32 erectile abnormalities 55 31 frequent (33%) Frequent (79-30%) HP:0100639
33 clubbing of fingers 55 31 frequent (33%) Frequent (79-30%) HP:0100759
34 sclerosis of foot bone 55 31 frequent (33%) Frequent (79-30%) HP:0100925
35 prolactin excess 55 31 occasional (7.5%) Occasional (29-5%) HP:0000870
36 acrocyanosis 55 31 occasional (7.5%) Occasional (29-5%) HP:0001063
37 polycythemia 55 31 occasional (7.5%) Occasional (29-5%) HP:0001901
38 restrictive deficit on pulmonary function testing 55 31 occasional (7.5%) Occasional (29-5%) HP:0002111
39 respiratory insufficiency due to muscle weakness 55 31 occasional (7.5%) Occasional (29-5%) HP:0002747
40 arterial thrombosis 55 31 occasional (7.5%) Occasional (29-5%) HP:0004420
41 venous thrombosis 55 31 occasional (7.5%) Occasional (29-5%) HP:0004936
42 lipodystrophy 55 31 occasional (7.5%) Occasional (29-5%) HP:0009125
43 hyperesthesia 55 31 occasional (7.5%) Occasional (29-5%) HP:0100963
44 abnormality of the endocrine system 55 Very frequent (99-80%)
45 edema 55 Frequent (79-30%)
46 muscle weakness 55 Frequent (79-30%)

MGI Mouse Phenotypes related to Poems Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 ANGPT2 EPO IL1B IL6 TNF VEGFA
2 immune system MP:0005387 9.63 ANGPT2 EPO IL1B IL6 TNF VEGFA
3 integument MP:0010771 9.43 ANGPT2 EPO IL1B IL6 TNF VEGFA
4 respiratory system MP:0005388 9.02 ANGPT2 EPO IL6 TNF VEGFA

Drugs & Therapeutics for Poems Syndrome

Drugs for Poems Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
2
Lenalidomide Approved Phase 2 191732-72-6 216326
3 Ixazomib Approved, Investigational Phase 2 1072833-77-2
4
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
5
Glycine Approved, Nutraceutical, Vet_approved Phase 2 56-40-6 750
6 Angiogenesis Inhibitors Phase 2
7 Angiogenesis Modulating Agents Phase 2
8 Anti-Bacterial Agents Phase 2
9 Antiemetics Phase 2
10 Anti-Infective Agents Phase 2
11 Anti-Inflammatory Agents Phase 2
12 Antineoplastic Agents, Hormonal Phase 2
13 Autonomic Agents Phase 2
14 BB 1101 Phase 2
15 Dexamethasone acetate Phase 2 1177-87-3
16 Gastrointestinal Agents Phase 2
17 glucocorticoids Phase 2
18 HIV Protease Inhibitors Phase 2
19 Hormone Antagonists Phase 2
20 Hormones Phase 2
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
22 Immunosuppressive Agents Phase 2
23 Peripheral Nervous System Agents Phase 2
24
protease inhibitors Phase 2
25 Anticoagulants Phase 2
26 Calcium, Dietary Phase 2
27 Chelating Agents Phase 2
28 Neurotransmitter Agents Phase 2
29 Citrate Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 POEMS Syndrome Treatment With Lenalidomide Unknown status NCT01639898 Phase 2 Lenalidomide and dexamethasone;Lenalidomide and dexamethasone
2 The Treatment of Lenalidomide in Patients With POEMS Syndrome Unknown status NCT00971685 Phase 2 Lenalidomide and dexamethasone
3 Study to Evaluate Lenalidomide Plus Dexamethasone in Patients With Newly Diagnosed POEMS Syndrome Completed NCT01816620 Phase 2 Lenalidomide, Dexamethasone
4 Efficacy and Safety of Lenalidomide as a Treatment for Recurrent or Refractory POEMS Syndrome Trial Completed NCT02193698 Phase 2 Lenalidomide+Dexamethasone
5 Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome Recruiting NCT02921893 Phase 2 Dexamethasone;Ixazomib Citrate;Lenalidomide

Search NIH Clinical Center for Poems Syndrome

Cochrane evidence based reviews: poems syndrome

Genetic Tests for Poems Syndrome

Anatomical Context for Poems Syndrome

MalaCards organs/tissues related to Poems Syndrome:

38
Skin, Lymph Node, Liver, Endothelial, Spleen, Bone, Testes

Publications for Poems Syndrome

Articles related to Poems Syndrome:

(show top 50) (show all 563)
# Title Authors Year
1
POEMS Syndrome: Diagnosis and Investigative Work-up. ( 29157614 )
2018
2
Cerebral pseudotumor as the first manifestation of POEMS syndrome: A case report. ( 29319491 )
2018
3
POEMS Syndrome: Therapeutic Options. ( 29157615 )
2018
4
The Efficacy and Long-Term Outcomes of Autologous Stem Cell Transplantation in POEMS Syndrome: a Nation-Wide Survey in Japan. ( 29409882 )
2018
5
What is the place of POEMS syndrome in the current classification of monoclonal gammopathies of renal significance? ( 29134615 )
2018
6
The Peripheral Neuropathies of POEMS Syndrome and Castleman Disease. ( 29157616 )
2018
7
Skull base plasmacytoma: A unique case of POEMS syndrome with a plasmacytoma causing craniocervical instability. ( 29100675 )
2018
8
Necrotizing autoimmune myopathy associated with POEMS syndrome report. ( 29088446 )
2018
9
Alcohol Misuse Link to POEMS Syndrome in a Patient. ( 28946631 )
2017
10
POEMS Syndrome with Biclonal Gammopathy: A Rare Association. ( 28893029 )
2017
11
An Adult with Polyneuropathy and Hypogonadism due to Poems Syndrome. ( 29056130 )
2017
12
POEMS syndrome: An elusive diagnosis. ( 28699264 )
2017
13
Autologous peripheral blood stem cell transplantation and the role of lenalidomide in patients affected by poems syndrome. ( 28913957 )
2017
14
Cerebral large-vessel vasculitis as an unusual manifestation of POEMS syndrome. ( 28432517 )
2017
15
Safety and Efficacy of Granulocyte Colony-Stimulating Factor Monotherapy for Peripheral Blood Stem Cell Collection in POEMS Syndrome. ( 27840209 )
2017
16
Pseudo Symmer's Pipe-Stem Fibrosis in Idiopathic Noncirrhotic Portal Hypertension Associated with POEMS Syndrome. ( 28848769 )
2017
17
POEMS SYNDROME: an Update. ( 28894560 )
2017
18
Glomeruloid Hemangioma as a Marker for the Early Diagnosis of POEMS Syndrome. ( 28392663 )
2017
19
Osteolytic-variant POEMS syndrome: an uncommon presentation of "osteosclerotic" myeloma. ( 28343327 )
2017
20
POEMS syndrome: a rare cause of exudative ascites and chronic peripheral neuropathy. ( 28637843 )
2017
21
Electrophysiologic features of POEMS syndrome compared with MGUS-related neuropathy. ( 28472865 )
2017
22
Lenalidomide and dexamethasone in patients with POEMS syndrome: results of a prospective, open-label trial. ( 29048107 )
2017
23
As white as ivory: sclerotic vertebra in POEMS syndrome. ( 28589896 )
2017
24
Utility of osteosclerotic lesion biopsy in diagnosis of POEMS syndrome: A case report. ( 29019884 )
2017
25
POEMS syndrome in a patient with rheumatoid arthritis. ( 28775105 )
2017
26
POEMS syndrome: 2017 Update on diagnosis, risk stratification, and management. ( 28699668 )
2017
27
POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report. ( 29113155 )
2017
28
Ischemic stroke in patients with POEMS syndrome: a case report and comprehensive analysis of literature. ( 29179528 )
2017
29
A rare cause of pericardial effusion and ascites: POEMS syndrome. ( 29333225 )
2017
30
Portal hypertension as the initial manifestation of POEMS syndrome: a case report. ( 28503308 )
2017
31
Endocrine perturbations in POEMS syndrome: Misunderstood features of a rare paraneoplastic syndrome. ( 28495325 )
2017
32
Coexistence of Quasi-moyamoya Disease and POEMS Syndrome in a Patient with Intracranial Hemorrhage: A Case Report and Literature Review. ( 28664017 )
2017
33
Acquired blue sclerae in POEMS syndrome. ( 28419450 )
2017
34
POEMS syndrome. ( 29279594 )
2017
35
Diagnostic challenges in POEMS syndrome presenting with polyneuropathy: A case series. ( 28566158 )
2017
36
Plexogenic pulmonary hypertension associated with POEMS syndrome. ( 28856089 )
2017
37
Bone lesions in Chinese POEMS syndrome patients: imaging characteristics and clinical implications. ( 27547585 )
2016
38
Stroke and POEMS syndrome: More than a chance association. ( 27841210 )
2016
39
Measurement of I^-isomerized C-terminal telopeptide of type I collagen in patients with POEMS syndrome: diagnostic, prognostic, and follow-up utilities. ( 27834942 )
2016
40
Rapidly Progressive Polyneuropathy in a Patient With Monoclonal Gammopathy: A Case Report of POEMS Syndrome and Beyond. ( 27100445 )
2016
41
Thalidomide and POEMS syndrome: a cautious step forward. ( 27496679 )
2016
42
Multiple glomeruloid hemangiomas without POEMS syndrome. ( 27279314 )
2016
43
Young patient with arterial thrombosis and skin changes as the onset manifestations: POEMS syndrome. ( 27738309 )
2016
44
Prognostic study for overall survival in patients with newly diagnosed POEMS syndrome. ( 27338259 )
2016
45
Temporal and Spatial Correlation Between Choroidal Thickness and Visual Function in a Case of POEMS Syndrome. ( 27726462 )
2016
46
Diagnosis of POEMS syndrome in a patient with long-standing neuropathy. ( 27776962 )
2016
47
POEMS syndrome: a rare case report. ( 27630082 )
2016
48
Cranial Pachymeningeal Involvement in POEMS Syndrome: Evaluation by Pre- and Post-contrast FLAIR and T1-weighted Imaging. ( 28003622 )
2016
49
Nerve pathologic features differentiate POEMS syndrome from CIDP. ( 27799073 )
2016
50
A special subtype of POEMS syndrome: IgG4 subtype. ( 27158350 )
2016

Variations for Poems Syndrome

Expression for Poems Syndrome

Search GEO for disease gene expression data for Poems Syndrome.

Pathways for Poems Syndrome

Pathways related to Poems Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 ANGPT2 EPO IL1B IL6 TNF VEGFA
2
Show member pathways
13.34 ANGPT2 EPO IL1B IL6 TNF VEGFA
3
Show member pathways
12.81 ANGPT2 EPO IL6 TNF VEGFA
4
Show member pathways
12.72 IL1B IL6 TNF VEGFA
5 12.63 ANGPT2 IL1B TNF VEGFA
6
Show member pathways
12.47 ANGPT2 IL1B IL6 TNF
7
Show member pathways
12.45 ANGPT2 IL6 TNF VEGFA
8
Show member pathways
12.38 IL1B IL6 TNF
9
Show member pathways
12.3 IL1B IL6 TNF
10
Show member pathways
12.22 IL1B IL6 TNF
11
Show member pathways
12.21 IL1B IL6 TNF
12
Show member pathways
12.16 IL1B IL6 TNF
13 12.12 IL1B IL6 TNF
14
Show member pathways
12.08 IL1B IL6 TNF
15 12.08 IL6 TNF VEGFA
16
Show member pathways
12.05 IL1B IL6 TNF
17 11.99 IL1B TNF VEGFA
18 11.95 IL1B IL6 TNF VEGFA
19 11.91 IL1B IL6 TNF
20 11.9 EPO IL6 TNF
21 11.86 IL1B IL6 TNF
22
Show member pathways
11.84 IL1B IL6 TNF
23 11.8 IL1B IL6 TNF
24 11.73 IL1B IL6 TNF VEGFA
25 11.67 IL1B IL6 TNF
26 11.66 IL1B IL6 TNF
27 11.62 ANGPT2 EPO IL6 VEGFA
28 11.58 IL1B IL6 TNF
29 11.55 IL1B IL6 TNF VEGFA
30 11.51 IL1B IL6 TNF
31 11.45 IL1B IL6 TNF
32 11.44 IL1B IL6 TNF
33 11.44 EPO IL1B IL6 TNF
34 11.42 EPO IL6 VEGFA
35 11.42 EPO IL1B IL6
36 11.4 IL6 TNF
37 11.4 TNF VEGFA
38 11.4 IL1B TNF
39 11.4 IL1B TNF
40 11.38 IL1B IL6 TNF
41
Show member pathways
11.35 IL1B TNF
42 11.28 ANGPT2 EPO VEGFA
43 11.26 IL1B IL6
44 11.24 EPO VEGFA
45 11.23 IL1B IL6 TNF
46 11.21 IL1B IL6 TNF
47 11.21 IL1B IL6 TNF VEGFA
48 11.16 IL1B IL6 TNF
49 11.12 IL1B IL6 TNF
50 11.06 ANGPT2 IL1B IL6 TNF

GO Terms for Poems Syndrome

Cellular components related to Poems Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ANGPT2 EPO IL1B IL6 TNF VEGFA
2 extracellular space GO:0005615 9.1 ANGPT2 EPO IL1B IL6 TNF VEGFA

Biological processes related to Poems Syndrome according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.92 EPO IL1B IL6 TNF
2 positive regulation of cell proliferation GO:0008284 9.87 EPO IL1B IL6 VEGFA
3 leukocyte migration GO:0050900 9.82 ANGPT2 IL1B TNF
4 response to hypoxia GO:0001666 9.79 ANGPT2 EPO VEGFA
5 positive regulation of protein phosphorylation GO:0001934 9.78 IL1B TNF VEGFA
6 positive regulation of gene expression GO:0010628 9.78 IL1B IL6 TNF VEGFA
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 IL1B IL6 TNF
8 positive regulation of angiogenesis GO:0045766 9.72 ANGPT2 IL1B VEGFA
9 positive regulation of DNA binding transcription factor activity GO:0051091 9.7 IL1B IL6 TNF
10 negative regulation of fat cell differentiation GO:0045599 9.68 IL6 TNF
11 positive regulation of cell adhesion GO:0045785 9.68 TNF VEGFA
12 positive regulation of cell division GO:0051781 9.68 IL1B VEGFA
13 protein kinase B signaling GO:0043491 9.68 IL1B TNF
14 positive regulation of interferon-gamma production GO:0032729 9.67 IL1B TNF
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 IL1B TNF
16 embryo implantation GO:0007566 9.67 EPO IL1B
17 acute-phase response GO:0006953 9.66 EPO IL6
18 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.66 IL1B TNF
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 IL1B TNF
20 positive regulation of phagocytosis GO:0050766 9.65 IL1B TNF
21 positive regulation of interleukin-8 production GO:0032757 9.65 IL1B TNF
22 positive regulation of p38MAPK cascade GO:1900745 9.64 IL1B VEGFA
23 positive regulation of protein complex assembly GO:0031334 9.63 TNF VEGFA
24 positive regulation of NF-kappaB import into nucleus GO:0042346 9.63 IL1B TNF
25 positive regulation of chemokine production GO:0032722 9.62 IL6 TNF
26 negative regulation of lipid catabolic process GO:0050995 9.6 IL1B TNF
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 IL1B TNF
28 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.58 IL1B VEGFA
29 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.58 IL1B TNF
30 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.58 IL6 TNF VEGFA
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 IL1B TNF
32 negative regulation of lipid storage GO:0010888 9.51 IL6 TNF
33 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.5 EPO IL6 VEGFA
34 response to salt stress GO:0009651 9.49 EPO TNF
35 positive regulation of chemokine biosynthetic process GO:0045080 9.46 IL1B TNF
36 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNF
37 positive regulation of fever generation GO:0031622 9.37 IL1B TNF
38 sequestering of triglyceride GO:0030730 9.26 IL1B TNF
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IL1B TNF
40 positive regulation of interleukin-6 production GO:0032755 9.13 IL1B IL6 TNF
41 regulation of receptor activity GO:0010469 9.02 EPO IL1B IL6 TNF VEGFA

Molecular functions related to Poems Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 EPO IL1B IL6 TNF VEGFA

Sources for Poems Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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