Poland Syndrome malady
Categories: Rare diseases, Reproductive diseases, Bone diseases, Fetal diseases, Oral diseases
Aliases & Descriptions for Poland Syndrome:
Orphanet epidemiological data:52
Inheritance: Autosomal dominant,Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Infancy,Neonatal; Age of death: normal life expectancy
Inheritance: autosomal dominant inheritance
Global: Rare diseases, Fetal diseases
Anatomical: Reproductive diseases, Bone diseases, Oral diseases
ICD10: 29 28
Rare gynaecological and obstetric diseases
Rare bone diseases
Developmental anomalies during embryogenesis
NIH Rare Diseases:46 Poland syndrome is characterized by an underdeveloped or absent chest muscle on one side of the body, absence of the breastbone portion (sternal) of the chest muscle, and webbing of the fingers of the hand on the same side. the cause of poland syndrome is not known. this syndrome is nearly always sporadic. it tends to occur on the right side and is more common in boys than girls. treatment typically involves surgical correction of the chest wall deformities. last updated: 2/24/2016
MalaCards based summary: Poland Syndrome, also known as poland sequence, is related to webster deming syndrome and dextrocardia, and has symptoms including asymmetry of the thorax, aplasia/hypoplasia of the nipples and aplasia of the pectoralis major muscle. An important gene associated with Poland Syndrome is LRP4 (LDL Receptor Related Protein 4), and among its related pathways is phospholipases. Affiliated tissues include heart, breast and liver.
Genetics Home Reference:24 Poland syndrome is a disorder in which affected individuals are born with missing or underdeveloped muscles on one side of the body, resulting in abnormalities that can affect the chest, shoulder, arm, and hand. The extent and severity of the abnormalities vary among affected individuals.
OMIM:50 Poland syndrome consists of unilateral absence or hypoplasia of the pectoralis muscle, most frequently involving the... (173800) more...
Wikipedia:69 Poland syndrome (also Poland\'s syndrome, Poland\'s syndactyly, Poland sequence, and Poland\'s anomaly)... more...
Symptoms by clinical synopsis from OMIM:173800
Clinical features from OMIM:173800
Symptoms:52 (show all 33)
HPO human phenotypes related to Poland Syndrome:(show all 44)
Drugs for Poland Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 206)
Interventional clinical trials:(show top 50) (show all 298)
Search NIH Clinical Center for Poland Syndrome
MalaCards organs/tissues related to Poland Syndrome:34
Heart, Breast, Liver, Endothelial, Testes, Bone, Ovary
Articles related to Poland Syndrome:(show top 50) (show all 127)
Search GEO for disease gene expression data for Poland Syndrome.
Biological processes related to Poland Syndrome according to GeneCards Suite gene sharing:
Molecular functions related to Poland Syndrome according to GeneCards Suite gene sharing:
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet