MCID: PLG003
MIFTS: 15

Polg-Related Disorders malady

Genetic diseases (common) category
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Summaries for Polg-Related Disorders

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MalaCards based summary: Polg-Related Disorders is related to alpers syndrome and childhood myocerebrohepatopathy spectrum disorders. An important gene associated with Polg-Related Disorders is POLG (polymerase (DNA directed), gamma). Related mouse phenotype embryogenesis.

GeneReviews summary for alpers

Aliases & Classifications for Polg-Related Disorders

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Polg-Related Disorders, Aliases & Descriptions:

Name: Polg-Related Disorders 19 20


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Polg-Related Disorders

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Diseases related to Polg-Related Disorders via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1alpers syndrome30.1C10orf2, POLG
2childhood myocerebrohepatopathy spectrum disorders10.2
3myoclonic epilepsy myopathy sensory ataxia10.2
4ataxia neuropathy spectrum10.2
5chronic progressive external ophthalmoplegia9.9POLG, C10orf2
6neuropathy9.9C10orf2, POLG
7spinocerebellar ataxia9.8C10orf2, POLG
8mitochondrial disorders9.8POLG, C10orf2

Graphical network of diseases related to Polg-Related Disorders:



Diseases related to polg-related disorders

Symptoms for Polg-Related Disorders

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Drugs & Therapeutics for Polg-Related Disorders

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Drug clinical trials:

Search ClinicalTrials for Polg-Related Disorders

Search NIH Clinical Center for Polg-Related Disorders

Genetic Tests for Polg-Related Disorders

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Genetic tests related to Polg-Related Disorders:

id Genetic test Affiliating Genes
1 Polg-Related Disorders20 POLG

Anatomical Context for Polg-Related Disorders

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Animal Models for Polg-Related Disorders or affiliated genes

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MGI Mouse Phenotypes related to Polg-Related Disorders:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.1POLG, C10orf2

Publications for Polg-Related Disorders

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Articles related to Polg-Related Disorders:

idTitleAuthorsYear
1
POLG-related disorders: defects of the nuclear and mitochondrial genome interaction. (22084276)
2011
2
POLG-Related Disorders (20301791)
1993

Variations for Polg-Related Disorders

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Expression for genes affiliated with Polg-Related Disorders

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Expression patterns in normal tissues for genes affiliated with Polg-Related Disorders

Search GEO for disease gene expression data for Polg-Related Disorders.

Pathways for genes affiliated with Polg-Related Disorders

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Compounds for genes affiliated with Polg-Related Disorders

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GO Terms for genes affiliated with Polg-Related Disorders

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Cellular components related to Polg-Related Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial nucleoidGO:0426459.1POLG, C10orf2

Biological processes related to Polg-Related Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:0082199.1POLG, C10orf2
2mitochondrial DNA replicationGO:0062648.8POLG, C10orf2

Molecular functions related to Polg-Related Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.1POLG, C10orf2

Products for genes affiliated with Polg-Related Disorders

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  • Antibodies
  • Proteins
  • Lysates

Sources for Polg-Related Disorders

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet