POLIO
MCID: PLM031
MIFTS: 51

Poliomyelitis (POLIO) malady

Neuronal category

Summaries for Poliomyelitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Poliomyelitis is a viral disease that can affect nerves and can lead to partial or full paralysis. it is caused by infection with the poliovirus which can be spread by direct person-to-person contact, by contact with infected mucus or phlegm from the nose or mouth, or by contact with infected feces. since the development of polio vaccine, the incidence of the disease has been greatly reduced. there are three basic patterns of polio infection: subclinical infections, nonparalytic, and paralytic. approximately 95% of infections are subclinical infections, which may not have symptoms. clinical poliomyelitis affects the central nervous system (brain and spinal cord) and is divided into nonparalytic and paralytic forms. it may occur after recovery from a subclinical infection. treatment is aimed at controlling symptoms while the infection runs its course. the prognosis depends on the form of the disease (subclinical, nonparalytic, or paralytic) and the site affected. if the spinal cord and brain are not involved, which is the case more than 90% of the time, complete recovery is likely. last updated: 9/7/2010

MalaCards: Poliomyelitis, also known as infantile paralysis, is related to agammaglobulinemia and amyotrophic lateral sclerosis, and has symptoms including fever, sore throat and headache. An important gene associated with Poliomyelitis is PVR (poliovirus receptor), and among its related pathways are Classical antibody-mediated complement activation and Fc-GammaR Pathway. The compounds valine and Palivizumab have been mentioned in the context of this disorder. Affiliated tissues include motor neurons, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:8 A viral infectious disease that results in destruction located in motor neurons, has material basis in human poliovirus 1, has material basis in human poliovirus 2, or has material basis in human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. the infection has symptom fever, has symptom sore throat, has symptom headache, has symptom vomiting, has symptom fatigue, has symptom neck stiffness, has symptom muscle spasms, and has symptom acute flaccid paralysis.

Wikipedia:64 Poliomyelitis /poʊlioʊmaɪəlaɪtɪs/, often called polio or infantile paralysis, is an acute, viral,... more...

Aliases & Classifications for Poliomyelitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 45Novoseek, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
poliomyelitis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Childhood; Age of death: Any age


Aliases & Descriptions:

poliomyelitis 8 43 10 49 61
infantile paralysis 43 61
polio 43 45


External Ids:

Disease Ontology8 DOID:4953
ICD9CM27 045, 045.9
NCIt40 C35550
MeSH35 D011051
MESH via Orphanet36 D011051
ICD10 via Orphanet26 A80
SNOMED-CT via Orphanet58 398102009
UMLS via Orphanet62 C0032371

Related Diseases for Poliomyelitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Poliomyelitis:



Diseases related to poliomyelitis

Clinical Features for Poliomyelitis

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 8)
  • fever
  • sore throat
  • headache
  • vomiting
  • fatigue
  • neck stiffness
  • muscle spasms
  • acute flaccid paralysis

Drugs & Therapeutics for Poliomyelitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Poliomyelitis

Drug clinical trials:

Search ClinicalTrials for Poliomyelitis

Search NIH Clinical Center for Poliomyelitis

Search CenterWatch for Poliomyelitis

Genetic Tests for Poliomyelitis

Anatomical Context for Poliomyelitis

Sources:
14FMA
See all sources

FMA organs/tissues related to Poliomyelitis:

14
Motor neurons

Animal Models for Poliomyelitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Poliomyelitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.7KCNJ12, PVR, ARHGEF1, FLNA, BTK, CD40LG
2MP:00053768.3KCNJ12, PVR, OPN4, ARHGEF1, FLNA, RHD

Publications for Poliomyelitis

Sources:
51PubMed
See all sources

Articles related to Poliomyelitis:

(show top 50)    (show all 846)
idTitleAuthorsYear
1
Poliomyelitis in Pakistan: time for the Muslim world to step in. (23623055)
2013
2
Combined immunodeficiency presenting with vaccine-associated paralytic poliomyelitis: a case report and narrative review of literature. (24294834)
2013
3
CORR Insights(Ar): Total Hip Arthroplasty Performed in Patients with Residual Poliomyelitis: Does it Work? (24249532)
2013
4
Notes from the field: outbreak of poliomyelitis--Somalia and Kenya, May 2013. (23760191)
2013
5
India without Poliomyelitis: Time to Make it a Reality. (22529531)
2012
6
Re: &quot;From emergence to eradication: the epidemiology of poliomyelitis deconstructed&quot;. (22156020)
2012
7
Expanding poliomyelitis and measles surveillance networks to establish surveillance for acute meningitis and encephalitis syndromes--Bangladesh, China, and India, 2006-2008. (23235298)
2012
8
Diaphragm dysfunction due to remote poliomyelitis in a patient with unexplained dyspnea. (21333958)
2011
9
WHO Working Group discussion on revision of the WHO recommendations for the production and control of poliomyelitis vaccines (oral): TRS Nos. 904 and 910. Report of Meeting held on 20-22 July 2010, Geneva, Switzerland. (21729731)
2011
10
Vaccine-associated paralytic poliomyelitis in immunodeficient children, Iran, 1995-2008. (20587188)
2010
11
Testing clinical surveillance of acute flaccid paralysis in Egypt post-eradication of poliomyelitis. (20955500)
2010
12
Relationship between perceived exertion and physiologic markers during arm exercise with able-bodied participants and participants with poliomyelitis. (20159133)
2010
13
Outbreak of poliomyelitis in Finland in 1984-85 - Re-analysis of viral sequences using the current standard approach. (19883702)
2010
14
Acute flaccid paralysis: a misdiagnosis of poliomyelitis. (19485162)
2009
15
Minimal change nephrotic syndrome in an 82 year old patient following a tetanus-diphteria-poliomyelitis-vaccination. (19656382)
2009
16
Fatigue, pain and muscle weakness are frequent after Guillain-BarrAc syndrome and poliomyelitis. (19266144)
2009
17
Progress toward poliomyelitis eradication--Afghanistan and Pakistan, 2008. (19265781)
2009
18
Increase in poliomyelitis cases in Nigeria. (18832440)
2008
19
Progress towards eradicating poliomyelitis in Nigeria, January 2007-August 2008. (18756634)
2008
20
Sensory physiology assessed by evoked potentials in survivors of poliomyelitis. (18816600)
2008
21
Performance of acute flaccid paralysis (AFP) surveillance and incidence of poliomyelitis, 2007 (data received in WHO headquarters as of 30 October 2007). (17992776)
2007
22
Performance of acute flaccid paralysis (AFP) surveillance and incidence of poliomyelitis, 2004-2005. (Data received in WHO headquarters as of 7 March 2006). (16671212)
2006
23
Clinical presentations of acute paralytic poliomyelitis. (16386337)
2006
24
Tibial lengthening and concomitant foot deformity correction in 14 patients with permanent deformity after poliomyelitis. (16097554)
2005
25
A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice. (15353596)
2004
26
Ensuring preparedness for potential poliomyelitis outbreaks: Recommendations for the US poliovirus vaccine stockpile from the National Vaccine Advisory Committee (NVAC) and the Advisory Committee on Immunization Practices (ACIP). (15583093)
2004
27
Life-long morbidity among Danes with poliomyelitis. (15031822)
2004
28
Fever and asymmetrical weakness in the summer: evidence of a West Nile virus-associated poliomyelitis-like illness. (14531478)
2003
29
Progress toward poliomyelitis eradication--India, Bangladesh, and Nepal, January 2001-June 2002. (12353744)
2002
30
A case of vaccine-associated paralytic poliomyelitis. (10940185)
2000
31
Depression in children with hemophilic arthropathy and poliomyelitis: a preliminary report. (10731865)
2000
32
Protocol for the investigation of acute flaccid paralysis and suspected paralytic poliomyelitis. (9553283)
1998
33
Paralytic poliomyelitis in a rural area of north India. (9069697)
1997
34
Poliovirus type 1 isolated from a vaccine-associated case of paralytic poliomyelitis in Brazil. (8731326)
1996
35
Vaccine-associated paralytic poliomyelitis. (8604208)
1996
36
Paralytic poliomyelitis. (1538863)
1992
37
Sero-epidemiological study of severe forms of paralytic poliomyelitis. (1660856)
1991
38
Immunization status in paralytic poliomyelitis--a hospital based study. (2599610)
1989
39
Paralytic poliomyelitis: a forgotten diagnosis? (3015321)
1986
40
Paralytic poliomyelitis. Rehabilitation point of view. (4077259)
1985
41
Control of paralytic poliomyelitis in the United States. (6740085)
1984
42
Induction of long-term immunity to paralytic poliomyelitis by use of non-infectious vaccine. (6150331)
1984
43
Injections and paralytic poliomyelitis in tropical Africa. (6249510)
1980
44
Combined immunodeficiency and vaccine-related poliomyelitis in a child with cartilage-hair hypoplasia. (165279)
1975
45
Letter: A possible association between paralytic poliomyelitis and multiple sclerosis. (4126643)
1973
46
Occurrence of myocarditis in paralytic poliomyelitis. (13826196)
1959
47
Paralytic poliomyelitis trends, 1957. (13662907)
1959
48
An illness resembling acute poliomyelitis caused by a virus of the Russian spring-summer encephalitis/louping ill group in Northern Ireland. (13515250)
1958
49
Paralytic poliomyelitis incidence as a guide to vaccination. (13446777)
1957
50
Incidence of previous type-II infection in patients with type-I paralytic poliomyelitis. (13368537)
1956

Genetic Variations for Poliomyelitis

Expression for genes affiliated with Poliomyelitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Poliomyelitis

Search GEO for disease gene expression data for Poliomyelitis.

Pathways for genes affiliated with Poliomyelitis

Sources:
54Reactome, 52QIAGEN, 30KEGG
See all sources

Compounds for genes affiliated with Poliomyelitis

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 29IUPHAR
See all sources

Compounds related to Poliomyelitis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1valine4510.4RPS27A, CS
2Palivizumab1110.4FCGR3B, FCGR2A, FCGR3A
3Intravenous Immunoglobulin1110.4FCGR3A, FCGR2A, FCGR3B
4Ibritumomab1110.4FCGR3B, FCGR2A, FCGR3A
5bevacizumab50 1111.4FCGR3B, FCGR2A, FCGR3A
6tositumomab50 1111.4FCGR3B, FCGR2A, FCGR3A
7alefacept45 1111.3FCGR3A, FCGR2A, FCGR3B
8Muromonab1110.3FCGR3B, FCGR2A, FCGR3A
9efalizumab45 1111.3FCGR3B, FCGR2A, FCGR3A
10basiliximab45 1111.3FCGR3A, FCGR2A, FCGR3B
11gemtuzumab ozogamicin45 1111.3FCGR3B, FCGR2A, FCGR3A
12natalizumab45 1111.3FCGR3B, FCGR2A, FCGR3A
13adalimumab45 50 1112.3FCGR3B, FCGR2A, FCGR3A
14cetuximab45 50 1112.3FCGR3A, FCGR2A, FCGR3B
15ivig4510.3BTK, CD40LG, FCGR2A, FCGR3A
16etanercept45 50 1112.2FCGR3A, FCGR2A, FCGR3B
17daclizumab45 1111.2FCGR3A, FCGR2A, FCGR3B, CD40LG
18alemtuzumab45 1111.2CD40LG, FCGR3B, FCGR2A, FCGR3A
19abciximab45 1111.2CD40LG, FCGR3B, FCGR2A, FCGR3A
20trastuzumab45 50 1112.2FCGR3B, FCGR2A, FCGR3A
21rituximab45 50 1112.2CD40LG, FCGR3B, FCGR2A, FCGR3A
22dbc-amp4510.2SYP, CHAT, FCGR3B
23glutamate4510.2CS, OPN4, CHAT, CD40LG
24silver4510.1RPS27A, SYP, CHAT
25formaldehyde45 2411.1RPS27A, SYP, CHAT, CD40LG
264-hydroxynonenal45 2411.1RPS27A, CS, CHAT
27histidine4510.0FCGR3A, FCGR2A, SYP, CS
28phenylalanine4510.0CS, FLNA, BTK, FCGR2A, FCGR3A
29polysaccharide459.9RPS27A, RHD, CD40LG, FCGR3B, FCGR2A
30acetylcholine45 50 29 11 2413.9RPS27A, CS, SYP, CHAT, CD40LG
31adenylate459.9CD40LG, RHD, OPN4, CS, RPS27A
32histamine45 29 2411.9FCGR2A, CD40LG, BTK, SYP
33dopamine45 29 11 2412.8CD40LG, CHAT, SYP, FLNA, RPS27A
34ethanol45 50 11 2412.8CS, RHD, SYP, CHAT
35palmitate459.8RPS27A, CS, RHD
36aspartate459.7KHSRP, CD40LG, CHAT, RHD, CS, RPS27A
37h2o2459.7RPS27A, RHD, SYP, FCGR3B, FCGR2A
38dexamethasone45 50 29 1112.6CS, SYP, CHAT, CD40LG, RPS27A
39atp45 2910.6RPS27A, CS, RHD, CHAT, BTK, FCGR2A
40arginine459.6RPS27A, CS, ARHGEF1, BTK, CD40LG, FCGR2A
41glycogen45 2410.4CHAT, SYP, CS, RPS27A
42lipid459.4CS, FLNA, RHD, SYP, CHAT, BTK
43serine459.3RPS27A, CS, FLNA, RHD, SYP, BTK
44calcium45 50 11 2412.1CS, OPN4, FLNA, RHD, SYP, CHAT
45tyrosine458.8RPS27A, ARHGEF1, FLNA, RHD, SYP, CHAT

GO Terms for genes affiliated with Poliomyelitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.4FCGR3A, KCNJ12, PVR, OPN4, ARHGEF1, FLNA

Biological processes related to Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:05077610.0FCGR3A, CD40LG, PVR

Molecular functions related to Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.9FCGR3A, FCGR2A, FCGR3B

Products for genes affiliated with Poliomyelitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Poliomyelitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet