POLIO
MCID: PLM031
MIFTS: 58

Poliomyelitis (POLIO) malady

Neuronal diseases category

Summaries for Poliomyelitis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Poliomyelitis is a viral disease that can affect nerves and can lead to partial or full paralysis. it is caused by infection with the poliovirus which can be spread by direct person-to-person contact, by contact with infected mucus or phlegm from the nose or mouth, or by contact with infected feces. since the development of polio vaccine, the incidence of the disease has been greatly reduced. there are three basic patterns of polio infection: subclinical infections, nonparalytic, and paralytic. approximately 95% of infections are subclinical infections, which may not have symptoms. clinical poliomyelitis affects the central nervous system (brain and spinal cord) and is divided into nonparalytic and paralytic forms. it may occur after recovery from a subclinical infection. treatment is aimed at controlling symptoms while the infection runs its course. the prognosis depends on the form of the disease (subclinical, nonparalytic, or paralytic) and the site affected. if the spinal cord and brain are not involved, which is the case more than 90% of the time, complete recovery is likely. last updated: 9/7/2010

MalaCards: Poliomyelitis, also known as infantile paralysis, is related to hepatitis and meningitis, and has symptoms including acute flaccid paralysis, neck stiffness and muscle spasms. An important gene associated with Poliomyelitis is PVR (poliovirus receptor), and among its related pathways are Classical antibody-mediated complement activation and Fc-GammaR Pathway. The compounds valine and Palivizumab have been mentioned in the context of this disorder. Affiliated tissues include motor neurons, spinal cord and lung, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:8 A viral infectious disease that results in destruction located in motor neurons, has material basis in human poliovirus 1, has material basis in human poliovirus 2, or has material basis in human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. the infection has symptom fever, has symptom sore throat, has symptom headache, has symptom vomiting, has symptom fatigue, has symptom neck stiffness, has symptom muscle spasms, and has symptom acute flaccid paralysis.

Wikipedia:63 Poliomyelitis /poʊlioʊmaɪəlaɪtɪs/, often called polio or infantile paralysis, is an acute, viral,... more...

Aliases & Classifications for Poliomyelitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
poliomyelitis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Childhood; Age of death: Any age


Aliases & Descriptions:

poliomyelitis 8 42 10 48 60
infantile paralysis 42 60
polio 42 44


External Ids:

Disease Ontology8 DOID:4953
ICD9CM27 045, 045.9
NCIt39 C35550
MeSH34 D011051
MESH via Orphanet35 D011051
SNOMED-CT via Orphanet57 398102009
UMLS via Orphanet61 C0032371
ICD10 via Orphanet26 A80.0, A80.1, A80.2 A80.3, A80.4, A80.9, more

Related Diseases for Poliomyelitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Poliomyelitis:



Diseases related to poliomyelitis

Clinical Features for Poliomyelitis

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8Disease Ontology
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Symptoms:

8 (show all 8)
  • acute flaccid paralysis
  • neck stiffness
  • muscle spasms
  • sore throat
  • vomiting
  • fatigue
  • headache
  • fever

Drugs & Therapeutics for Poliomyelitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Poliomyelitis

Drug clinical trials:

Search ClinicalTrials for Poliomyelitis

Search NIH Clinical Center for Poliomyelitis

Search CenterWatch for Poliomyelitis

Genetic Tests for Poliomyelitis

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Anatomical Context for Poliomyelitis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Poliomyelitis:

32
Spinal cord, Lung, Brain, Bone, Breast, Testes

FMA organs/tissues related to Poliomyelitis:

14
Motor neurons

Animal Models for Poliomyelitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Poliomyelitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.7KCNJ12, PVR, ARHGEF1, FLNA, BTK, CD40LG
2MP:00053768.3KCNJ12, PVR, OPN4, ARHGEF1, FLNA, RHD

Publications for Poliomyelitis

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50PubMed
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Articles related to Poliomyelitis:

(show top 50)    (show all 840)
idTitleAuthorsYear
1
Expansion of acute flaccid paralysis surveillance: beyond poliomyelitis. (24033476)
2013
2
Performance of acute flaccid paralysis (AFP) surveillance and incidence of poliomyelitis. 2012. (23620909)
2013
3
How French physicians manage with a future change in the primary vaccination of infants against diphtheria, tetanus, pertussis and poliomyelitis? A qualitative study with focus groups. (23782853)
2013
4
Apropos risks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis. (23249227)
2012
5
Periacetabular osteotomy for containment of the nonarthritic dysplastic hip secondary to poliomyelitis. (21159992)
2010
6
Re: Immunity against poliomyelitis in refugees in Italy. (20920062)
2010
7
Pathology in practice. Diagnosis: Poliomyelitis with intraneuronal Negri bodies. (20673107)
2010
8
Performance of acute flaccid paralysis (AFP) surveillance and incidence of poliomyelitis, 2008. (19326584)
2009
9
Public health response to imported case of poliomyelitis, Australia, 2007. (19891859)
2009
10
The pathogenesis of poliomyelitis: what we don't know. (18585526)
2008
11
Performance of acute flaccid paralysis (AFP) surveillance and incidence of poliomyelitis, 2008 (data received in WHO headquarters as of 4 March 2008). (18350686)
2008
12
Immunisation against poliomyelitis: moving forward. (18424327)
2008
13
Dissociation of the femoral head and trunion after constrained conversion total hip arthroplasty for poliomyelitis. (17562428)
2007
14
Global poliomyelitis eradication: status and implications. (17448799)
2007
15
Nonparalytic poliomyelitis in Lyme borreliosis. (16861483)
2006
16
Re-emerging poliomyelitis--is Australia's surveillance adequate? (17120482)
2006
17
Rational design of genetically stable, live-attenuated poliovirus vaccines of all three serotypes: relevance to poliomyelitis eradication. (16912313)
2006
18
Performance of acute flaccid paralysis (AFP) surveillance and incidence of poliomyelitis, 2006 (data received in WHO headquarters as of 7 November 2006). (17111573)
2006
19
Salk and Sabin: poliomyelitis immunisation. (15489385)
2004
20
Progress towards global eradication of poliomyelitis, 2003 and January-April 2004. (15227955)
2004
21
Poliomyelitis vaccination campaign to recommence in Nigeria. (14700052)
2004
22
Measles vaccination coverage during poliomyelitis national immunization days in Burkina Faso, 1999. (12721895)
2003
23
Progress towards poliomyelitis eradication in India, 2002. (12664718)
2003
24
Molecular epidemiology of type 2 vaccine-associated paralytic poliomyelitis in china. (14583649)
2003
25
Outbreak of poliomyelitis due to type 3 poliovirus, northern India, 1999-2000: injections a major contributing factor. (12714548)
2003
26
Progress and challenges toward poliomyelitis eradication in Indonesia. (15115136)
2003
27
Progress toward poliomyelitis eradication--Egypt, 2002. (12680521)
2003
28
Postoperative respiratory arrest in a post poliomyelitis patient. (12846642)
2003
29
Age-specific seroprevalence of poliomyelitis, diphtheria and tetanus antibodies in Spain. (12558336)
2002
30
Outbreak of paralytic poliomyelitis in the Chechen Republic in 1995. (11763333)
2001
31
Prolonged poliovirus excretion in an immunodeficient person with vaccine-associated paralytic poliomyelitis. (9233551)
1997
32
Case report: acute vaccine-associated paralytic poliomyelitis. (9040673)
1997
33
Paralytic poliomyelitis (1989-1994): report from a sentinel center. (9057401)
1996
34
Observations on the age and spatial distribution of paralytic poliomyelitis in Ibadan, Nigeria. (1699475)
1990
35
Neonatal paralytic poliomyelitis. A case report. (3947264)
1986
36
Paralytic poliomyelitis in Bundelkhand region. (6642614)
1983
37
A study of incidence of paralytic poliomyelitis in Bhopal: agglomeration from 1972-78. (7262985)
1981
38
Study of the HLA antigen in Arab children with paralytic poliomyelitis. (422339)
1979
39
Paralytic poliomyelitis in children. (924651)
1977
40
An association of HL-A3 and HL-A7 with paralytic poliomyelitis. (4837313)
1974
41
Serum and urinary creatine and creatinine in paralytic poliomyelitis. (5121527)
1971
42
Coxsackie A7 virus and paralytic poliomyelitis. (5855230)
1965
43
Incidence of paralytic poliomyelitis in Japan after mass vaccination. (14456545)
1962
44
Paralytic poliomyelitis in Canada, 1950. (13754798)
1960
45
Study of cases of paralytic poliomyelitis in triply-vaccinated persons. (13569855)
1958
46
Body image and paralytic poliomyelitis; an experimental approach. (13492034)
1957
47
A study of the basic aspects of neutralization of two animal viruses, western equine encephalitis virus and poliomyelitis virus. (13312221)
1956
48
Observations on the use of gamma globulin as a control measure in paralytic poliomyelitis in siblings; report of two cases. (13213643)
1954
49
Experimental studies on passive immunization against poliomyelitis. II. The prophylactic effect of human gamma globulin on paralytic poliomyelitis in cynomolgus monkeys after virus feeding. (14933392)
1952
50
The diagnostic difficulties on non-paralytic poliomyelitis. (18132542)
1949

Genetic Variations for Poliomyelitis

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Expression for genes affiliated with Poliomyelitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Poliomyelitis

Search GEO for disease gene expression data for Poliomyelitis.

Pathways for genes affiliated with Poliomyelitis

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53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Poliomyelitis

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR
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Compounds related to Poliomyelitis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1valine4410.4RPS27A, CS
2Palivizumab1110.4FCGR2A, FCGR3A, FCGR3B
3Intravenous Immunoglobulin1110.4FCGR3B, FCGR3A, FCGR2A
4bevacizumab49 1111.4FCGR3A, FCGR2A, FCGR3B
5tositumomab49 1111.4FCGR3B, FCGR2A, FCGR3A
6Ibritumomab1110.4FCGR3A, FCGR3B, FCGR2A
7alefacept44 1111.3FCGR3B, FCGR3A, FCGR2A
8Muromonab1110.3FCGR3B, FCGR2A, FCGR3A
9efalizumab44 1111.3FCGR2A, FCGR3B, FCGR3A
10basiliximab44 1111.3FCGR3A, FCGR3B, FCGR2A
11gemtuzumab ozogamicin44 1111.3FCGR3A, FCGR3B, FCGR2A
12natalizumab44 1111.3FCGR3A, FCGR2A, FCGR3B
13adalimumab44 49 1112.3FCGR3A, FCGR2A, FCGR3B
14cetuximab44 49 1112.3FCGR2A, FCGR3A, FCGR3B
15ivig4410.3BTK, CD40LG, FCGR2A, FCGR3A
16etanercept44 49 1112.2FCGR3A, FCGR2A, FCGR3B
17daclizumab44 1111.2FCGR3B, FCGR3A, FCGR2A, CD40LG
18alemtuzumab44 1111.2FCGR2A, FCGR3B, FCGR3A, CD40LG
19abciximab44 1111.2CD40LG, FCGR3B, FCGR2A, FCGR3A
20trastuzumab44 49 1112.2FCGR3B, FCGR2A, FCGR3A
21rituximab44 49 1112.2CD40LG, FCGR3A, FCGR2A, FCGR3B
22dbc-amp4410.2SYP, FCGR3B, CHAT
23glutamate4410.2CS, OPN4, CHAT, CD40LG
244-hydroxynonenal44 2411.1CS, CHAT, RPS27A
25silver4410.1CHAT, SYP, RPS27A
26formaldehyde44 2411.1RPS27A, CHAT, CD40LG, SYP
27histidine4410.0CS, FCGR2A, FCGR3A, SYP
28phenylalanine4410.0FCGR3A, FCGR2A, BTK, FLNA, CS
29polysaccharide449.9RHD, RPS27A, CD40LG, FCGR3B, FCGR2A
30acetylcholine44 49 28 11 2413.9CHAT, SYP, CD40LG, CS, RPS27A
31adenylate449.9RPS27A, CS, OPN4, RHD, CD40LG
32histamine44 28 2411.9BTK, SYP, FCGR2A, CD40LG
33dopamine44 28 11 2412.8SYP, FLNA, RPS27A, CHAT, CD40LG
34ethanol44 49 11 2412.8CHAT, CS, RHD, SYP
35palmitate449.8RPS27A, CS, RHD
36aspartate449.7KHSRP, CD40LG, CHAT, CS, RPS27A, RHD
37h2o2449.7FCGR3B, SYP, RPS27A, FCGR2A, RHD
38dexamethasone44 49 28 1112.6CD40LG, CHAT, SYP, RPS27A, CS
39atp44 2810.6CHAT, RHD, RPS27A, CS, FCGR2A, BTK
40arginine449.6RPS27A, CS, FCGR2A, CD40LG, BTK, FCGR3A
41glycogen44 2410.4RPS27A, CHAT, CS, SYP
42lipid449.4RHD, FLNA, BTK, FCGR3B, CHAT, SYP
43serine449.3FLNA, FCGR3B, BTK, RHD, CS, RPS27A
44calcium44 49 11 2412.1SYP, CHAT, FLNA, OPN4, RHD, BTK
45tyrosine448.8FCGR3A, FCGR2A, KHSRP, BTK, RPS27A, ARHGEF1

GO Terms for genes affiliated with Poliomyelitis

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16Gene Ontology
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Cellular components related to Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.4FCGR3A, KCNJ12, PVR, OPN4, ARHGEF1, FLNA

Biological processes related to Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:05077610.0FCGR3A, CD40LG, PVR

Molecular functions related to Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.9FCGR3A, FCGR2A, FCGR3B

Products for genes affiliated with Poliomyelitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Poliomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet