Poliomyelitis malady

NIH Rare Diseases: Poliomyelitis is a viral disease that can affect nerves and can lead to partial or full paralysis. It is caused by infection with the poliovirus which can be spread by direct person-to-person contact, by contact with infected mucus or phlegm from the nose or mouth, or by contact with infected feces. Since the development of polio vaccine, the incidence of the disease has been greatly reduced. There are three basic patterns of polio infection: subclinical infections, nonparalytic, and paralytic. Approximately 95% of infections are subclinical infections, which may not have symptoms. Clinical poliomyelitis affects the central nervous system (brain and spinal cord) and is divided into nonparalytic and paralytic forms. It may occur after recovery from a subclinical infection. Treatment is aimed at controlling symptoms while the infection runs its course. The prognosis depends on the form of the disease (subclinical, nonparalytic, or paralytic) and the site affected. If the spinal cord and brain are not involved, which is the case more than 90% of the time, complete recovery is likely.³⁰

MalaCards: Poliomyelitis, also known as POLIO, is related to paralytic poliomyelitis and paralysis, and has symptoms including fever, sore throat and headache. An important gene associated with Poliomyelitis is PVR (poliovirus receptor), and among its related pathways are OX40 Pathway and Staphylococcus aureus infection. The compounds ivig and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include motor neurons, brain and spinal cord, and related mouse phenotypes are skeleton and hematopoietic system.

Disease Ontology: A viral infectious disease that results in destruction located in motor neurons, has material basis in human poliovirus 1, has material basis in human poliovirus 2, or has material basis in human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. the infection has symptom fever, has symptom sore throat, has symptom headache, has symptom vomiting, has symptom fatigue, has symptom neck stiffness, has symptom muscle spasms, and has symptom acute flaccid paralysis.⁶

Wikipedia: Poliomyelitis (pron.: /poʊlioʊmaɪəlaɪtɪs/), often called polio or infantile paralysis, is an...⁴⁴ more...

Aliases & Descriptions:

poliomyelitis 6 30 8 43 polio 30 33 32

infantile paralysis 30

Diseases related to poliomyelitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 451)

id	Related Disease	Score	Top Affiliating Genes
1	paralytic poliomyelitis	32.7	BTK, CD40LG, NDUFAF3, PVR
2	paralysis	28.1	KCNJ12, IL10, RPS27A, PVR, SYP
3	amyotrophic lateral sclerosis	27.4	CHAT, FCGR3B, ICAM1, TNF, RPS27A, SYP
4	lateral sclerosis	27.4	CHAT, FCGR3B, ICAM1, TNF, RPS27A, SYP
5	neurodegeneration	24.8	KHSRP, CHAT, IL10, IFNG, TNF, RPS27A
6	immunodeficiency	24.7	BTK, CD40LG, FCGR2A, FCGR3B, IL10, IL4
7	tetanus	24.4	ATP8A2, CD40LG, IL10, IL4, IGHV4-39, IFNG
8	influenza	23.4	ATP8A2, CD40LG, IL10, IL4, IGHV4-39, IFNG
9	typhus	13.5	CD40LG, IGHV4-39, CS
10	legionellosis	13.4	CD40LG, IGHV4-39
11	heparin-induced thrombocytopenia	13.4	CD40LG, FCGR2A, FCGR3A
12	rh isoimmunization	13.4	RHD, AFP
13	congenital rubella	13.4	CD40LG, IGHV4-39
14	facial hemiatrophy	13.3	ARHGEF1, EVC
15	severe congenital neutropenia	13.3	BTK, FCGR2A, FCGR3A, FCGR3B
16	immunodeficiency with hyper igm type 1	13.3	BTK, CD40LG, IL4
17	agammaglobulinemia	13.3	BTK, CD40LG, IL4
18	pure red-cell aplasia	13.3	CD40LG, RPS27A, SYP
19	hepatitis d	13.2	CD40LG, IGHV4-39, TNF
20	cat-scratch disease	13.2	IGHV4-39, TNF, CS
21	pyoderma	13.2	BTK, CD40LG, TNF
22	peripheral arterial occlusive disease	13.1	CD40LG, ICAM1, CS
23	localized scleroderma	13.1	CD40LG, ARHGEF1, IL4
24	amyloid tumor	13.1	CHAT, RPS27A, SYP
25	japanese encephalitis	13.1	CD40LG, IL4, IGHV4-39, DPT
26	dissecting cellulitis of the scalp	13.0	ICAM1, TNF
27	progressive supranuclear palsy	13.0	CHAT, RPS27A, SYP, CS
28	supranuclear palsy	13.0	CHAT, RPS27A, SYP, CS
29	endotoxin hyporesponsiveness	13.0	TNF, RPS27A
30	primary immunodeficiency disease	13.0	CD40LG, FCGR3A, FCGR3B, IL4, IGHV4-39
31	sertoli cell tumor	12.9	ICAM1, SYP, AFP
32	cerebral malaria	12.9	ICAM1, TNF
33	dengue disease	12.9	IGHV4-39, ICAM1, TNF
34	arterial occlusive disease	12.9	CD40LG, ICAM1, CS
35	tuberculous uveitis	12.9	IFNG, TNF
36	glomerulopathy	12.8	CD40LG, FCGR2A, ICAM1, RPS27A
37	dermatitis herpetiformis	12.8	CD40LG, ICAM1, TNF
38	chorea	12.8	RPS27A, RHD, SYP
39	hyperlipoproteinemia type iii	12.8	CD40LG, ICAM1, TNF
40	posterior uveitis	12.8	CD40LG, IFNG, TNF
41	endocarditis	12.8	KHSRP, CD40LG, FCGR2A, TNF, CS
42	alcoholic hepatitis	12.7	ICAM1, TNF, RPS27A
43	acrodermatitis	12.7	CD40LG, IFNG, TNF
44	histoplasmosis	12.7	CD40LG, IFNG, TNF
45	punctate inner choroidopathy	12.7	IL10, TNF
46	takayasu's arteritis	12.6	CD40LG, ICAM1, TNF
47	adult-onset still's disease	12.6	FCGR2A, FCGR3A, ICAM1, TNF
48	viral encephalitis	12.6	CD40LG, IL10, ICAM1
49	lyme disease	12.6	CD40LG, IGHV4-39, IFNG, TNF
50	motor neuron disease	12.6	CHAT, TNF, RPS27A, PVR, SYP

Symptoms: fever, sore throat, headache, vomiting, fatigue, neck stiffness, muscle spasms, acute flaccid paralysis.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to poliomyelitis:

²²

FMA organs/tissues related to poliomyelitis:

¹¹

MGI Mouse Phenotypes related to poliomyelitis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	9.7	DLG1, EVC, CHAT
2	hematopoietic system phenotype	MP:0005397	9.3	RHD, ARHGEF1, FLNA, BTK
3	immune system phenotype	MP:0005387	8.1	PVR, TNF, IFNG, ARHGEF1, FLNA, KHSRP
4	homeostasis/metabolism phenotype	MP:0005376	7.6	BTK, AFP, OPN4, PVR, RHD, DLG1
5	mortality/aging	MP:0010768	7.3	AFP, PES1, DLG1, EVC, IFNG, FCGR2A
6	reproductive system phenotype	MP:0005389	6.6	DLG1, TNF, EVC, IFNG, IL4, IL10
7	vision/eye phenotype	MP:0005391	6.4	OPN4, DPT, NID1, DLG1, TNF, ICAM1

Articles related to poliomyelitis:

(show all 20)

id	Title	Authors	Year	Affiliating Genes
1	Ala67Thr mutation in the poliovirus receptor CD155 is a potential risk factor for vaccine and wild-type paralytic poliomyelitis. (19319949)	Kindberg E.... Svensson L.	2009	PVR
2	Novel BTK mutation presenting with vaccine-associated paralytic poliomyelitis. (18317803)	Mamishi S.... Parvaneh N.	2008	BTK
3	Cellular and humoral immunodeficiency in children wi th vaccine-associated paralytic poliomyelitis (17297880)	Krasnoproshina L.I.... Cherniavskaia O.P.	2006	CD40LG
4	Feasibility study to develop a common in vitro D antigen assay for inactivated poliomyelitis vaccines. (16336935)	Morgeaux S.... Daas A.	2005	RHD
5	A poliomyelitis model through mucosal infection in transgenic mice bearing human poliovirus receptor, TgPVR21. (15033568)	Nagata N.... Nomoto A.	2004	PVR
6	A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice. (15353596)	Dufresne A.T.... Gromeier M.	2004	ICAM1
7	Prior poliomyelitis-IVIg treatment reduces proinflamm atory cytokine production. (15081258)	Gonzalez H.... Olsson T.	2004	TNF, IL4, IFNG
8	Establishment of European Pharmacopoeia BRP batch 2 for inactivated poliomyelitis vaccine for in vitro D antigen assay. (14563307)	Fuchs F.... Milne C.	2003	RHD
9	The neuropathology observed in wild-type mice inoculated with human poliovirus mirrors human paralytic poliomyelitis. (12220986)	Ford D.J.... Jubelt B.	2002	PVR
10	Prior poliomyelitis-evidence of cytokine production in the central nervous system. (12409177)	Gonzalez H.... Olsson T.	2002	TNF, IL4, IFNG
11	Fcgamma receptor IIIA polymorphism as a risk factor for acute poliomyelitis. (12447772)	Rekand T.... Vedeler C.A.	2002	FCGR3A, FCGR2A, FCGR3B
12	Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis. (10915595)	Gromeier M.... Wimmer E.	2000	PVR
13	Evolution of the Sabin type 1 poliovirus in humans: c haracterization of strains isolated from patients with vaccine-associated paral ytic poliomyelitis. (9311861)	Georgescu M.M.... Delpeyroux F.	1997	PVR
14	Immunohistochemical studies on clustered pericapillary bodies in the spinal cord of post-poliomyelitis patients. (8841662)	Ikemoto A.... Hirano A.	1996	RPS27A, SYP
15	Comparative immunohistochemical study on synaptophysin expression in the anterior horn of post-poliomyelitis and sporadic amyotrophic lateral sclerosis. (8922059)	Ikemoto A.... Hirano A.	1996	SYP
16	Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis. (7476091)	Gromeier M.... Wimmer E.	1995	PVR
17	Comparative study of spinal cord ubiquitin expression in post-poliomyelitis and sporadic amyotrophic lateral sclerosis. (7517092)	Ito H.... Hirano A.	1994	RPS27A
18	Prior poliomyelitis-reduced capillary supply and metabolic enzyme content in hypertrophic slow-twitch (type I) muscle fibres. (2030351)	Borg K.... Henriksson J.	1991	CS
19	Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. (2170026)	Ren R.B.... Racaniello V.R.	1990	PVR
20	Ankle joint instability in poliomyelitis. (5024025)	Mukherjee A.... Natarajan K.	1972	DLG1, KCNJ12

Genes related to poliomyelitis according to GeneCards:

(show all 31)

id	Symbol	Description	Score	GeneCards Section Context
1	PVR	poliovirus receptor	11.0	Publications
2	NDUFAF3	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3	11.0
3	BTK	Bruton agammaglobulinemia tyrosine kinase	11.0	Publications
4	CD40LG	CD40 ligand	11.0	Publications
5	IGHV4-39	immunoglobulin heavy variable 4-39	11.0
6	C17orf80	chromosome 17 open reading frame 80	11.0
7	PES1	pescadillo ribosomal biogenesis factor 1	11.0
8	OPN4	opsin 4	11.0
9	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	11.0	Publications
10	KHSRP	KH-type splicing regulatory protein	11.0
11	DPT	dermatopontin	11.0
12	RHD	Rh blood group, D antigen	11.0	Publications
13	FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	11.0	Publications
14	KCNJ12	potassium inwardly-rectifying channel, subfamily J, member 12	11.0	Publications
15	SYP	synaptophysin	11.0	Publications
16	CS	citrate synthase	11.0	Publications
17	EVC	Ellis van Creveld syndrome	11.0
18	FLNA	filamin A, alpha	11.0
19	FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	11.0	Publications
20	NID1	nidogen 1	11.0
21	ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	11.0
22	RPS27A	ribosomal protein S27a	11.0	Publications
23	CHAT	choline O-acetyltransferase	11.0
24	DLG1	discs, large homolog 1 (Drosophila)	11.0	Publications
25	AFP	alpha-fetoprotein	11.0
26	IL4	interleukin 4	11.0	Publications
27	ATP8A2	ATPase, aminophospholipid transporter, class I, type 8A, member 2	11.0
28	ICAM1	intercellular adhesion molecule 1	11.0	Publications
29	TNF	tumor necrosis factor	11.0	Publications
30	IFNG	interferon, gamma	11.0	Publications
31	IL10	interleukin 10	11.0	Publications

Pathways related to poliomyelitis according to GeneDecks:

(show all 26)

id	Pathway	Score	Top Affiliating Genes
1	OX40 Pathway36	10.3	IL4
2	Staphylococcus aureus infection20	9.2	ICAM1, IL10, FCGR3B, FCGR3A, FCGR2A
3	Asthma20	9.1	TNF, IL4, IL10, CD40LG
4	Intestinal immune network for IgA production20	9.1	CD40LG, IL10, IL4
5	MIF Mediated Glucocorticoid Regulation36	9.0	TNF, IL4, IL10, BTK
6	MIF Regulation of Innate Immune Cells36	8.9	BTK, IL10, IL4, TNF
7	PEDF Induced Signaling36	8.8	BTK, IL10, IL4, TNF
8	Immune response_MIF-mediated glucocorticoid regulation41	8.8	TNF, ICAM1, IFNG
9	Immune response MIF-mediated glucocorticoid regulation10	8.8	TNF, ICAM1, IFNG
10	all-trans-Retinoic Acid Signaling in Brain36	8.7	TNF, IL4, IL10, BTK
11	Immune response CD16 signaling in NK cells10	8.6	TNF, IFNG, IL4, FCGR3A
12	Immune response_CD16 signaling in NK cells41	8.6	FCGR3A, IL4, IFNG, TNF
13	Osteoclast differentiation20	8.6	TNF, IFNG, FCGR3B, FCGR3A, FCGR2A, BTK
14	Th1 Differentiation37	8.5	IL10, IFNG, TNF
15	Toxoplasmosis20	8.4	TNF, IFNG, IL10, CD40LG
16	Natural killer cell mediated cytotoxicity20	8.4	TNF, ICAM1, IFNG, FCGR3B, FCGR3A
17	Cytokine Network36	8.4	IL10, IL4, IFNG, TNF
18	THC Differentiation Pathway36	8.4	IL10, IL4, IFNG, TNF
19	Allograft rejection20	8.3	TNF, IFNG, IL4, IL10, CD40LG
20	African trypanosomiasis20	8.3	TNF, ICAM1, IFNG, IL10
21	Tuberculosis20	8.2	TNF, IFNG, IL10, FCGR3B, FCGR3A, FCGR2A
22	Malaria20	8.2	TNF, ICAM1, IFNG, IL10, CD40LG
23	Systemic lupus erythematosus20	8.1	TNF, IFNG, IL10, FCGR3B, FCGR3A, FCGR2A
24	Cytokine-cytokine receptor interaction20	8.1	TNF, IFNG, IL4, IL10, CD40LG
25	T cell receptor signaling pathway20	8.0	DLG1, TNF, IFNG, IL4, IL10, CD40LG
26	Leishmaniasis20	7.9	FCGR2A, TNF, IFNG, IL4, IL10, FCGR3B

Compounds related to poliomyelitis according to GeneDecks:

(show top 50)    (show all 105)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.6	BTK, FCGR3A
2	ionomycin32	10.5	BTK, SYP
3	daclizumab32 9 9	12.1	FCGR2A, FCGR3B, FCGR3A, CD40LG
4	alemtuzumab32 9 9	12.1	FCGR2A, CD40LG, FCGR3B, FCGR3A
5	Palivizumab9 9	11.1	FCGR2A, FCGR3A, FCGR3B
6	abciximab32 9 9	12.0	FCGR3A, CD40LG, FCGR3B, FCGR2A
7	Intravenous Immunoglobulin9 9	10.9	FCGR3A, FCGR2A, FCGR3B
8	tositumomab34 9 9	11.9	FCGR2A, FCGR3A, FCGR3B
9	alefacept32 9 9	11.6	FCGR3B, FCGR2A, FCGR3A, TNF
10	aspartate32	9.5	KHSRP, RPS27A, CD40LG, RHD, NID1, CHAT
11	glutamate32	9.2	NID1, CS, OPN4, RPS27A, DLG1, CHAT
12	efalizumab32 9 9	11.2	FCGR3A, FCGR3B, ICAM1, TNF, FCGR2A
13	cdp57132	9.1	TNF, IL10, ICAM1
14	valine32	9.1	DLG1, FCGR2A, CS, RPS27A, AFP, FCGR3A
15	betaseron32	9.0	IL10, IL4, IFNG
16	rituximab32 34 9 9	12.0	FCGR3A, FCGR3B, CD40LG, FCGR2A, IL10, TNF
17	polysaccharide32	8.9	RPS27A, FCGR3B, AFP, RHD, CD40LG, FCGR2A
18	alpha-galactosylceramide32	8.7	IL10, IL4, IFNG
19	chloroquine32 34 9 9	11.7	IL10, SYP, RPS27A, TNF, IL4
20	con a32	8.6	IFNG, IL4, AFP, IL10
21	ribavirin32 34 9 9	11.6	CD40LG, IL4, AFP, IFNG, IL10
22	il-1232	8.4	CD40LG, IL10, IL4, IFNG, TNF
23	rolipram32 42	9.4	IL10, TNF, IFNG, IL4
24	paraffin32	8.4	IL10, CHAT, IL4, CD40LG, RPS27A, SYP
25	thalidomide32 42 9 9	11.4	CD40LG, IL10, IFNG, TNF, AFP
26	adalimumab32 9 9	10.3	IL10, FCGR3B, IFNG, FCGR2A, FCGR3A, TNF
27	etanercept32 9 9	10.3	FCGR2A, IL10, TNF, IFNG, FCGR3A, FCGR3B
28	polyinosinic-polycytidylic acid32	8.3	IFNG, IL10, IL4, TNF
29	interferon gamma32	8.0	TNF, ICAM1, IFNG, IL10, IL4
30	genistein32 9 18 9	11.0	SYP, TNF, ICAM1, IFNG, FCGR3B, CD40LG
31	polymyxin b32	8.0	IFNG, IL10, IL4, ICAM1, TNF
32	prednisolone32 9 9	10.0	FCGR2A, FCGR3B, TNF, IFNG, IL10
33	gm-csf32	8.0	IL4, IFNG, IL10, ICAM1, TNF
34	tarc32	8.0	IL4, IL10, ICAM1, TNF, IFNG
35	arginine32	8.0	FCGR3A, FCGR2A, ARHGEF1, CD40LG, BTK, IFNG
36	pentoxifylline32 9 9	10.0	IL10, IL4, IFNG, ICAM1, TNF
37	herbimycin a32 42	8.9	FCGR3A, IL4, IFNG, CD40LG, TNF, ICAM1
38	okt332	7.9	IL10, IL4, IFNG, ICAM1, TNF, CD40LG
39	neopterin32	7.9	ICAM1, IL4, TNF, CD40LG, IL10, IFNG
40	natalizumab32 9 9	9.8	FCGR2A, TNF, ICAM1, IFNG, IL10, FCGR3B
41	simvastatin32 34 42 9 18 9	12.6	IL10, TNF, AFP, ICAM1, IFNG, IL4
42	rantes32	7.6	IFNG, ICAM1, TNF, CD40LG, IL10, IL4
43	h2o232	7.5	AFP, SYP, RHD, RPS27A, TNF, FCGR3B
44	actinomycin d32	7.4	FCGR2A, CD40LG, IL4, IFNG, AFP, RPS27A
45	serine32	7.4	NID1, CS, SYP, RHD, RPS27A, DLG1
46	cyclosporin a32 42	8.3	ICAM1, TNF, RPS27A, CS, IFNG, CD40LG
47	histamine32 18	8.3	IL10, ICAM1, IFNG, TNF, SYP, IL4
48	vegf32	6.8	SYP, RPS27A, TNF, ICAM1, IFNG, IL10
49	tyrosine32	6.8	KHSRP, CHAT, FLNA, ARHGEF1, RHD, RPS27A
50	dexamethasone32 42 34 9 9	10.4	AFP, SYP, IL10, RPS27A, CHAT, CS

Cellular components related to poliomyelitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	7.7	CD40LG, TNF, ICAM1, IFNG, IL4, FCGR3A
2	plasma membrane	GO:005886	6.8	ICAM1, TNF, DLG1, RPS27A, PVR, FCGR3B
3	extracellular space	GO:005615	6.5	AFP, PVR, DPT, TNF, ICAM1, IFNG

Biological processes related to poliomyelitis according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of isotype switching	GO:045191	9.8	IL4, IL10
2	type 2 immune response	GO:042092	9.6	IL10, IL4
3	receptor biosynthetic process	GO:032800	9.5	TNF, IL10
4	regulation of immunoglobulin secretion	GO:051023	9.4	CD40LG, TNF
5	B cell differentiation	GO:030183	9.4	IL4, IL10, CD40LG
6	regulation of immune response	GO:050776	9.4	PVR, ICAM1, IL4, FCGR3A, CD40LG
7	positive regulation of vitamin D biosynthetic process	GO:060557	9.3	TNF, IFNG
8	positive regulation of isotype switching to IgG isotypes	GO:048304	9.2	IL4, IFNG
9	negative regulation of cytokine secretion involved in immune response	GO:002740	9.2	IL10, TNF
10	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.2	TNF, IFNG
11	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.0	RPS27A, TNF, ICAM1, BTK
12	positive regulation of chemokine biosynthetic process	GO:045080	8.9	TNF, IFNG, IL4
13	positive regulation of MHC class II biosynthetic process	GO:045348	8.9	CD40LG, IL10, IL4, IFNG
14	negative regulation of growth of symbiont in host	GO:044130	8.8	IL10, IFNG, TNF
15	positive regulation of nitric oxide biosynthetic process	GO:045429	8.7	IFNG, ICAM1, TNF
16	response to drug	GO:042493	7.5	TNF, ICAM1, IFNG, IL4, IL10, CHAT

Molecular functions related to poliomyelitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	IgG binding	GO:019864	9.6	FCGR2A, FCGR3A, FCGR3B
2	cytokine activity	GO:005125	8.0	CD40LG, IL10, IL4, IFNG, TNF