POLIO
MCID: PLM031
MIFTS: 53

Poliomyelitis (POLIO) malady

Rare diseases, Neuronal diseases, Infectious diseases categories

Summaries for Poliomyelitis

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9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Poliomyelitis is a viral disease that can affect nerves and can lead to partial or full paralysis. it is caused by infection with the poliovirus which can be spread by direct person-to-person contact, by contact with infected mucus or phlegm from the nose or mouth, or by contact with infected feces. since the development of polio vaccine, the incidence of the disease has been greatly reduced. there are three basic patterns of polio infection: subclinical infections, nonparalytic, and paralytic. approximately 95% of infections are subclinical infections, which may not have symptoms. clinical poliomyelitis affects the central nervous system (brain and spinal cord) and is divided into nonparalytic and paralytic forms. it may occur after recovery from a subclinical infection. treatment is aimed at controlling symptoms while the infection runs its course. the prognosis depends on the form of the disease (subclinical, nonparalytic, or paralytic) and the site affected. if the spinal cord and brain are not involved, which is the case more than 90% of the time, complete recovery is likely. last updated: 9/7/2010

MalaCards: Poliomyelitis, also known as infantile paralysis, is related to agammaglobulinemia and paralytic poliomyelitis, and has symptoms including acute flaccid paralysis, muscle spasms and neck stiffness. An important gene associated with Poliomyelitis is PVR (poliovirus receptor), and among its related pathways are Cell adhesion molecules (CAMs) and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The compounds ivig and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include motor neurons, spinal cord and brain.

Disease Ontology:9 A viral infectious disease that results in destruction located in motor neurons, has material basis in human poliovirus 1, has material basis in human poliovirus 2, or has material basis in human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. the infection has symptom fever, has symptom sore throat, has symptom headache, has symptom vomiting, has symptom fatigue, has symptom neck stiffness, has symptom muscle spasms, and has symptom acute flaccid paralysis.

Wikipedia:66 Poliomyelitis /po?lio?ma??la?t?s/, often called polio or infantile paralysis, is an acute, viral,... more...

Aliases & Classifications for Poliomyelitis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH, 41NCIt, 37MESH via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
poliomyelitis:
Prevalence: <1/1000000; Age of onset: Childhood; Age of death: Any age


Aliases & Descriptions:

poliomyelitis 9 44 11 50 63
infantile paralysis 44 63
polio 44 46


External Ids:

Disease Ontology9 DOID:4953
ICD9CM28 045, 045.9
MeSH36 D011051
NCIt41 C35550
MESH via Orphanet37 D011051
SNOMED-CT via Orphanet60 398102009
UMLS via Orphanet64 C0032371
ICD10 via Orphanet27 A80.0, A80.1, A80.2 A80.3, A80.4, A80.9, more

Related Diseases for Poliomyelitis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Poliomyelitis:



Diseases related to poliomyelitis

Symptoms for Poliomyelitis

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9Disease Ontology
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Symptoms:

9 (show all 8)
  • acute flaccid paralysis
  • muscle spasms
  • neck stiffness
  • sore throat
  • vomiting
  • fatigue
  • headache
  • fever

Drugs & Therapeutics for Poliomyelitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Poliomyelitis

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Anatomical Context for Poliomyelitis

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Poliomyelitis:

34
Spinal cord, Brain, Bone, Breast, Testes, Lung

FMA organs/tissues related to Poliomyelitis:

15
Motor neurons

Animal Models for Poliomyelitis or affiliated genes

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Publications for Poliomyelitis

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53PubMed
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Articles related to Poliomyelitis:

(show top 50)    (show all 832)
idTitleAuthorsYear
1
&quot;Can't walk nor raise arms to head&quot;: Harvey Cushing's surgical treatment of poliomyelitis. (21301395)
2012
2
The effect of mass immunisation campaigns and new oral poliovirus vaccines on the incidence of poliomyelitis in Pakistan and Afghanistan, 2001-11: a retrospective analysis. (22766207)
2012
3
Tibial lengthening using a humeral intramedullary nail combined with a single-plane external fixator for leg discrepancy in sequelae of poliomyelitis. (20975588)
2011
4
Femoral neck bone mineral density in ambulatory men with poliomyelitis. (20309527)
2011
5
Vaccine-associated paralytic poliomyelitis in immunodeficient children, Iran, 1995-2008. (20587188)
2010
6
MR finding in vaccine-associated paralytic poliomyelitis. (20567967)
2010
7
The threat of vaccine associated poliomyelitis in India: medicolegal issues involved. (21157179)
2010
8
The pathogenesis of poliomyelitis: what we don't know. (18585526)
2008
9
An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine and diphtheria and tetanus toxoids adsorbed combined with inactivated poliomyelitis vaccine. (17045366)
2007
10
Dissociation of the femoral head and trunion after constrained conversion total hip arthroplasty for poliomyelitis. (17562428)
2007
11
Myasthenia gravis masquerading as post-poliomyelitis syndrome. (16546772)
2006
12
Performance of acute flaccid paralysis (AFP) surveillance and incidence of poliomyelitis, 2004-2005. (Data received in WHO headquarters as of 7 March 2006). (16671212)
2006
13
Poliomyelitis vaccination. 1955. (16550785)
2006
14
A randomised controlled study of the reactogenicity of an acellular pertussis-containing pentavalent infant vaccine compared to a quadrivalent whole cell pertussis-containing vaccine and oral poliomyelitis vaccine, when given concurrently with meningococcal group C conjugate vaccine to healthy UK infants at 2, 3 and 4 months of age. (16517034)
2006
15
Clinical presentations of acute paralytic poliomyelitis. (16386337)
2006
16
Progress towards poliomyelitis eradication--poliomyelitis outbreak in Sudan, 2004. (15739947)
2005
17
Progress toward poliomyelitis eradication--India, January 2004-May 2005. (16001016)
2005
18
Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy. (15717298)
2005
19
Differentiating traumatic neuritis from poliomyelitis. (14606778)
2003
20
Paralytic poliomyelitis caused by a vaccine-derived polio virus in an antibody-deficient Argentinean child. (12828159)
2003
21
The neuropathology observed in wild-type mice inoculated with human poliovirus mirrors human paralytic poliomyelitis. (12220986)
2002
22
Progress toward poliomyelitis eradication--India, Bangladesh, and Nepal, January 2001-June 2002. (12353744)
2002
23
Progress toward poliomyelitis and dracunculiasis eradication--Sudan, 1999-2000. (11411832)
2001
24
Amyotrophic lateral sclerosis in an adult following acute paralytic poliomyelitis in early childhood. (10090681)
1999
25
Vaccine-associated paralytic poliomyelitis. (8989358)
1997
26
Epidemiological considerations on age distribution of paralytic poliomyelitis. (8816037)
1996
27
Immunization status in hospitalized children with acute paralytic poliomyelitis. (8935263)
1995
28
Completeness of reporting for paralytic poliomyelitis, United States, 1980 through 1991. Implications for estimating the risk of vaccine-associated disease. (8180638)
1994
29
Ataxia-telangiectasia in a child with vaccine-associated paralytic poliomyelitis. (1517916)
1992
30
Prevalence of paralytic poliomyelitis in a rural and urban community of Delhi. (2286434)
1990
31
Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. (2170026)
1990
32
Imported paralytic poliomyelitis--United States, 1986. (3095620)
1986
33
Paralytic poliomyelitis in children in Ethiopia: a review of 2604 cases. (3698975)
1986
34
Outbreak of paralytic poliomyelitis. (2857255)
1985
35
Paralytic poliomyelitis in Finland. (2863531)
1985
36
Late progressive muscular atrophy and antecedent poliomyelitis. (6983825)
1982
37
Comparison of methods for estimating the frequency of paralytic poliomyelitis in developing countries. (312162)
1979
38
Paralytic poliomyelitis in children. (924651)
1977
39
Acute paralytic poliomyelitis at Kenyatta National Hospital 1969-1971. (4845811)
1974
40
Guest editorial: outbreak of paralytic poliomyelitis. (4687474)
1973
41
Role of breast feeding in paralytic poliomyelitis with special reference to immunisation. (5028650)
1972
42
Studies on paralytic poliomyelitis in Cairo, U.A.R., 1957-1958. (13792243)
1960
43
Preconceptions about vaccination against paralytic poliomyelitis. (13637560)
1959
44
Paralytic Poliomyelitis in Canada, Week ending October 4, 1958. (20325819)
1958
45
Prognosis of limb inequality following paralytic poliomyelitis. (13612205)
1958
46
Papilledema and pseudotumor cerebri following poliomyelitis. (13424005)
1957
47
C reactive protein in serous meningitis and paralytic poliomyelitis. (13470510)
1957
48
Glossopharyngeal breathing as an aid to recovery from paralytic poliomyelitis. (13313534)
1956
49
Paralytic poliomyelitis. (14371167)
1955
50
POSSIBLE relationship between paralytic poliomyelitis and subcutaneous injection of immunizing agents and other medicinal substances. (14911309)
1952

Variations for Poliomyelitis

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Expression for genes affiliated with Poliomyelitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Poliomyelitis

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Pathways for genes affiliated with Poliomyelitis

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51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 58SinoBiological, 55R&D Systems, 54QIAGEN
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Compounds for genes affiliated with Poliomyelitis

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46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Poliomyelitis according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1ivig469.6BTK, CD40LG
2ionomycin469.4BTK, CD40LG
3phenylalanine469.3BTK, CS
4daclizumab46 1210.3FCGR3B, CD40LG
5alemtuzumab46 1210.3FCGR3B, CD40LG
6abciximab46 1210.3CD40LG, FCGR3B
7rituximab46 52 1211.2CD40LG, FCGR3B
8phosphatidylserine46 30 1211.1FCGR3B, CD40LG
9ascorbic acid46 2510.0CD40LG, CS
10polysaccharide469.0FCGR3B, CD40LG
11arginine469.0CD40LG, CS, BTK
12adp46 30 2511.0CD40LG, BTK, CS
13genistein46 30 62 3 25 1213.8FCGR3B, BTK, CD40LG
14lipid468.6CS, FCGR3B, BTK
15serine468.2FCGR3B, CS, BTK, CD40LG

GO Terms for genes affiliated with Poliomyelitis

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17Gene Ontology
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Cellular components related to Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.1CD40LG, BTK, PVR, FCGR3B

Biological processes related to Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:0507769.4CD40LG, PVR

Products for genes affiliated with Poliomyelitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Poliomyelitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet