POLIO
MCID: PLM031
MIFTS: 58

Poliomyelitis (POLIO) malady

Neuronal diseases category

Summaries for Poliomyelitis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Poliomyelitis is a viral disease that can affect nerves and can lead to partial or full paralysis. it is caused by infection with the poliovirus which can be spread by direct person-to-person contact, by contact with infected mucus or phlegm from the nose or mouth, or by contact with infected feces. since the development of polio vaccine, the incidence of the disease has been greatly reduced. there are three basic patterns of polio infection: subclinical infections, nonparalytic, and paralytic. approximately 95% of infections are subclinical infections, which may not have symptoms. clinical poliomyelitis affects the central nervous system (brain and spinal cord) and is divided into nonparalytic and paralytic forms. it may occur after recovery from a subclinical infection. treatment is aimed at controlling symptoms while the infection runs its course. the prognosis depends on the form of the disease (subclinical, nonparalytic, or paralytic) and the site affected. if the spinal cord and brain are not involved, which is the case more than 90% of the time, complete recovery is likely. last updated: 9/7/2010

MalaCards: Poliomyelitis, also known as infantile paralysis, is related to hepatitis and meningitis, and has symptoms including acute flaccid paralysis, muscle spasms and neck stiffness. An important gene associated with Poliomyelitis is PVR (poliovirus receptor), and among its related pathways are Classical antibody-mediated complement activation and Fc-GammaR Pathway. The compounds valine and Palivizumab have been mentioned in the context of this disorder. Affiliated tissues include motor neurons, spinal cord and lung, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:8 A viral infectious disease that results in destruction located in motor neurons, has material basis in human poliovirus 1, has material basis in human poliovirus 2, or has material basis in human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. the infection has symptom fever, has symptom sore throat, has symptom headache, has symptom vomiting, has symptom fatigue, has symptom neck stiffness, has symptom muscle spasms, and has symptom acute flaccid paralysis.

Wikipedia:63 Poliomyelitis /poʊlioʊmaɪəlaɪtɪs/, often called polio or infantile paralysis, is an acute, viral,... more...

Aliases & Classifications for Poliomyelitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
poliomyelitis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Childhood; Age of death: Any age


Aliases & Descriptions:

poliomyelitis 8 42 10 48 60
infantile paralysis 42 60
polio 42 44


External Ids:

Disease Ontology8 DOID:4953
ICD9CM27 045, 045.9
NCIt39 C35550
MeSH34 D011051
MESH via Orphanet35 D011051
SNOMED-CT via Orphanet57 398102009
UMLS via Orphanet61 C0032371
ICD10 via Orphanet26 A80.0, A80.1, A80.2 A80.3, A80.4, A80.9, more

Related Diseases for Poliomyelitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Poliomyelitis:



Diseases related to poliomyelitis

Clinical Features for Poliomyelitis

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8Disease Ontology
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Symptoms:

8 (show all 8)
  • acute flaccid paralysis
  • muscle spasms
  • neck stiffness
  • fatigue
  • vomiting
  • headache
  • sore throat
  • fever

Drugs & Therapeutics for Poliomyelitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Poliomyelitis

Drug clinical trials:

Search ClinicalTrials for Poliomyelitis

Search NIH Clinical Center for Poliomyelitis

Search CenterWatch for Poliomyelitis

Genetic Tests for Poliomyelitis

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Anatomical Context for Poliomyelitis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Poliomyelitis:

32
Spinal cord, Lung, Brain, Bone, Testes, Breast

FMA organs/tissues related to Poliomyelitis:

14
Motor neurons

Animal Models for Poliomyelitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Poliomyelitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.7PVR, ARHGEF1, FLNA, BTK, CD40LG, KHSRP
2MP:00053768.3FCGR3A, KCNJ12, PVR, OPN4, ARHGEF1, FLNA

Publications for Poliomyelitis

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50PubMed
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Articles related to Poliomyelitis:

(show top 50)    (show all 840)
idTitleAuthorsYear
1
Immunogenicity and safety of a booster dose of diphtheria, tetanus, acellular pertussis and inactivated poliomyelitis vaccine (Tdap-IPV; Repevax) administered concomitantly versus non-concomitantly with an influenza vaccine (Vaxigrip) to adults aged a8Y60 years: an open-label, randomised trial. (23313654)
2013
2
CORR Insights(Ar): Total Hip Arthroplasty Performed in Patients with Residual Poliomyelitis: Does it Work? (24249532)
2013
3
Statin-induced myopathy in a patient with previous poliomyelitis. (23370588)
2013
4
Mechanical and thermal hyperalgesia in patients with poliomyelitis. (23415862)
2013
5
Poliomyelitis and its elimination in Cuba: An historical overview. Author reply. (24392511)
2013
6
India without Poliomyelitis: Time to Make it a Reality. (22529531)
2012
7
Concomitant CNS pathology in a patient with amyotropic lateral sclerosis following poliomyelitis in childhood. (21545774)
2011
8
Prediction of peak oxygen uptake from ratings of perceived exertion during arm exercise in able-bodied and persons with poliomyelitis. (20514056)
2011
9
Performance of acute flaccid paralysis (AFP) surveillance and incidence of poliomyelitis, 2011. (21969939)
2011
10
Performance of acute flaccid paralysis (AFP) surveillance and incidence of poliomyelitis, 2011. (21706911)
2011
11
Outbreak of poliomyelitis in Tajikistan in 2010: risk for importation and impact on polio surveillance in Europe? (20460088)
2010
12
Vaccination against tetanus, diphtheria, pertussis and poliomyelitis in adult travellers. (20541135)
2010
13
Protection against poliomyelitis in Europe. (20460087)
2010
14
Minimal change nephrotic syndrome in an 82 year old patient following a tetanus-diphteria-poliomyelitis-vaccination. (19656382)
2009
15
West nile poliomyelitis in a 7-year-old child. (18940559)
2008
16
Poliomyelitis: concerns for polio-free countries. (17224220)
2007
17
Vaccine-associated paralytic poliomyelitis in a patient with MHC class II deficiency. (17509935)
2007
18
One-year post-primary antibody persistence and booster immune response to a fully liquid five-component acellular pertussis, diphtheria, tetanus, inactivated poliomyelitis, Haemophilus influenzae type b conjugate vaccine. (17349809)
2007
19
Eradication versus control for poliomyelitis. (17630031)
2007
20
Bilateral substantia nigra involvement in vaccine-associated poliomyelitis. (16717231)
2006
21
Cellular and humoral immunodeficiency in children with vaccine-associated paralytic poliomyelitis]. (17297880)
2006
22
No evidence for prolonged excretion of polioviruses in persons with residual paralytic poliomyelitis in Ethiopia, Pakistan and Guatemala. (16682222)
2006
23
The relation between walking capacity and clinical correlates in survivors of chronic spinal poliomyelitis. (16813782)
2006
24
Progress towards global poliomyelitis eradication: preparation for the oral poliovirus vaccine cessation era. (15571172)
2004
25
Ensuring preparedness for potential poliomyelitis outbreaks: Recommendations for the US poliovirus vaccine stockpile from the National Vaccine Advisory Committee (NVAC) and the Advisory Committee on Immunization Practices (ACIP). (15583093)
2004
26
Progress toward global eradication of poliomyelitis, January 2003-April 2004. (15215742)
2004
27
A case of vaccine-associated paralytic poliomyelitis. (10940185)
2000
28
Immunization status of hospitalized children with acute paralytic poliomyelitis. (8772852)
1996
29
Vaccine-associated paralytic poliomyelitis. (8350905)
1993
30
Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. (2170026)
1990
31
Paralytic poliomyelitis 1976-1988: report from a Sentinel Centre. (2361758)
1990
32
Leads from the MMWR. Paralytic poliomyelitis--Senegal, 1986-1987: update on the N-IPV efficacy study. (3367468)
1988
33
Problems in the rehabilitation of paralytic poliomyelitis. (3679459)
1987
34
A review of paralytic poliomyelitis cases occurring after polio vaccination. (3794352)
1986
35
Effectiveness of polio vaccination coverage in reducing the incidence of paralytic poliomyelitis in a highly endemic area of Bombay city. (6716301)
1984
36
Acute paralytic poliomyelitis among Nigerian children in Enugu. (7308096)
1981
37
Guest editorial: outbreak of paralytic poliomyelitis. (4687474)
1973
38
Epidemiology of paralytic poliomyelitis. (5976571)
1966
39
Clinical paralytic poliomyelitis due to enteroviruses other than poliovirus. (13983659)
1963
40
Occurrence of myocarditis in paralytic poliomyelitis. (13826196)
1959
41
Influence of prior active immunization on the presence of poliomyelitis virus in the pharynx and stools of family contacts of patients with paralytic poliomyelitis. (13542077)
1958
42
An illness resembling acute poliomyelitis caused by a virus of the Russian spring-summer encephalitis/louping ill group in Northern Ireland. (13515250)
1958
43
Paralytic poliomyelitis in a spastic. (13450320)
1957
44
Paralytic poliomyelitis incidence as a guide to vaccination. (13446777)
1957
45
Glossopharyngeal breathing as an aid to recovery from paralytic poliomyelitis. (13313534)
1956
46
Clinical aspects of non-paralytic poliomyelitis and a clinical comparison of poliomyelitis epidemics due to type I and type II virus. (14382886)
1955
47
Follow-up study in seventy-five cases of non-paralytic poliomyelitis. (13061308)
1953
48
Neuronitis simulating acute anterior poliomyelitis; case report. (14943024)
1952
49
Paralytic poliomyelitis following injury. (14825879)
1951
50
Paralytic Poliomyelitis. (20787521)
1949

Genetic Variations for Poliomyelitis

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Expression for genes affiliated with Poliomyelitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Poliomyelitis

Search GEO for disease gene expression data for Poliomyelitis.

Pathways for genes affiliated with Poliomyelitis

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Sources:
53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Poliomyelitis

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR
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Compounds related to Poliomyelitis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1valine4410.4RPS27A, CS
2Palivizumab1110.4FCGR3B, FCGR2A, FCGR3A
3Intravenous Immunoglobulin1110.4FCGR3A, FCGR2A, FCGR3B
4Ibritumomab1110.4FCGR3B, FCGR2A, FCGR3A
5bevacizumab49 1111.4FCGR3B, FCGR2A, FCGR3A
6tositumomab49 1111.4FCGR3B, FCGR2A, FCGR3A
7alefacept44 1111.3FCGR3A, FCGR2A, FCGR3B
8Muromonab1110.3FCGR3B, FCGR2A, FCGR3A
9efalizumab44 1111.3FCGR3B, FCGR2A, FCGR3A
10basiliximab44 1111.3FCGR3A, FCGR2A, FCGR3B
11gemtuzumab ozogamicin44 1111.3FCGR3B, FCGR2A, FCGR3A
12natalizumab44 1111.3FCGR3B, FCGR2A, FCGR3A
13adalimumab44 49 1112.3FCGR3B, FCGR2A, FCGR3A
14cetuximab44 49 1112.3FCGR3A, FCGR2A, FCGR3B
15ivig4410.3BTK, CD40LG, FCGR2A, FCGR3A
16etanercept44 49 1112.2FCGR3A, FCGR2A, FCGR3B
17daclizumab44 1111.2FCGR3A, FCGR2A, FCGR3B, CD40LG
18alemtuzumab44 1111.2CD40LG, FCGR3B, FCGR2A, FCGR3A
19abciximab44 1111.2CD40LG, FCGR3B, FCGR2A, FCGR3A
20trastuzumab44 49 1112.2FCGR3B, FCGR2A, FCGR3A
21rituximab44 49 1112.2CD40LG, FCGR3B, FCGR2A, FCGR3A
22dbc-amp4410.2SYP, CHAT, FCGR3B
23glutamate4410.2CS, OPN4, CHAT, CD40LG
24silver4410.1RPS27A, SYP, CHAT
25formaldehyde44 2411.1RPS27A, SYP, CHAT, CD40LG
264-hydroxynonenal44 2411.1RPS27A, CS, CHAT
27histidine4410.0FCGR3A, FCGR2A, SYP, CS
28phenylalanine4410.0CS, FLNA, BTK, FCGR2A, FCGR3A
29polysaccharide449.9RPS27A, RHD, CD40LG, FCGR3B, FCGR2A
30acetylcholine44 49 28 11 2413.9RPS27A, CS, SYP, CHAT, CD40LG
31adenylate449.9CD40LG, RHD, OPN4, CS, RPS27A
32histamine44 28 2411.9FCGR2A, CD40LG, BTK, SYP
33dopamine44 28 11 2412.8CD40LG, CHAT, SYP, FLNA, RPS27A
34ethanol44 49 11 2412.8CS, RHD, SYP, CHAT
35palmitate449.8RPS27A, CS, RHD
36aspartate449.7KHSRP, CD40LG, CHAT, RHD, CS, RPS27A
37h2o2449.7RPS27A, RHD, SYP, FCGR3B, FCGR2A
38dexamethasone44 49 28 1112.6CS, SYP, CHAT, CD40LG, RPS27A
39atp44 2810.6RPS27A, CS, RHD, CHAT, BTK, FCGR2A
40arginine449.6RPS27A, CS, ARHGEF1, BTK, CD40LG, FCGR2A
41glycogen44 2410.4CHAT, SYP, CS, RPS27A
42lipid449.4CS, FLNA, RHD, SYP, CHAT, BTK
43serine449.3RPS27A, CS, FLNA, RHD, SYP, BTK
44calcium44 49 11 2412.1CS, OPN4, FLNA, RHD, SYP, CHAT
45tyrosine448.8RPS27A, ARHGEF1, FLNA, RHD, SYP, CHAT

GO Terms for genes affiliated with Poliomyelitis

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16Gene Ontology
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Cellular components related to Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.4FCGR3A, KCNJ12, PVR, OPN4, ARHGEF1, FLNA

Biological processes related to Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:05077610.0FCGR3A, CD40LG, PVR

Molecular functions related to Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.9FCGR3A, FCGR2A, FCGR3B

Products for genes affiliated with Poliomyelitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Poliomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet