MCID: PLY017
MIFTS: 60

Polyarteritis Nodosa malady

Rare diseases, Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases categories

Summaries for Polyarteritis Nodosa

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NIH Rare Diseases:41 Polyarteritis nodosa is a serious blood vessel disease in which medium-sized arteries become swollen and damaged. it occurs when certain immune cells attack the affected arteries preventing vital oxygen and nourishment. signs and symptoms may include fever, fatigue, weakness, loss of appetite, weight loss, muscle and joint aches, and abdominal pain. the skin may show rashes, swelling, ulcers, and lumps. when nerve cells are involved numbness, pain, burning, and weakness may be present. polyarteritis nodosa can cause serious health complications including strokes, seizures, and kidney failure. treatment often includes steroids and other drugs to suppress the immune system. last updated: 1/16/2012

MalaCards based summary: Polyarteritis Nodosa, also known as küssmaul-maier disease, is related to churg-strauss syndrome and mononeuritis multiplex, and has symptoms including renal insufficiency, nephropathy and cutis marmorata. An important gene associated with Polyarteritis Nodosa is CECR1 (cat eye syndrome chromosome region, candidate 1), and among its related pathways are Selenium Pathway and Immune response IL 23 signaling pathway. The compounds hydroxychloroquine and clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and bone, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Wikipedia:63 Polyarteritis nodosa, also known as panarteritis nodosa,periarteritis nodosa,), Kussmaul disease or... more...

Aliases & Classifications for Polyarteritis Nodosa

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Polyarteritis Nodosa, Aliases & Descriptions:

Name: Polyarteritis Nodosa 9 41 11 43 47 60
Küssmaul-Maier Disease 41 47
 
Periarteritis Nodosa 41 47
Pan 41


Classifications:



Characteristics (Orphanet epidemiological data):

47
polyarteritis nodosa:
Inheritance: Autosomal recessive,Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:9810
MeSH33 D010488
ICD9CM27 446.0
NCIt38 C26847
Orphanet47 767
MESH via Orphanet34 D010488
ICD10 via Orphanet26 M30.0
UMLS via Orphanet61 C0031036
ICD1025 M30.0

Related Diseases for Polyarteritis Nodosa

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Diseases related to Polyarteritis Nodosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 334)
idRelated DiseaseScoreTop Affiliating Genes
1churg-strauss syndrome31.7MPO, PRTN3, LTF
2mononeuritis multiplex31.5MPO, PRTN3
3hepatitis31.5GPT, IFNA1, IFNA2, CD40LG
4retinal artery occlusion31.4APOH
5crohn's disease31.4LTF, CRP
6sneddon syndrome31.4APOH
7retinal vasculitis31.3APOH
8thrombophlebitis31.3APOH
9cholecystitis31.3GPT
10sinusitis31.2PRTN3, IGES
11adult-onset still's disease31.2CRP
12lupus erythematosus31.2APOH, IFNA2
13ulcerative colitis31.1PRTN3, CRP, LTF
14vasculitis31.1APOH, MPO, PRTN3, MEFV, IFNA2, CRP
15hepatitis b31.1HLA-DRB1, GPT, IFNA1, IFNA2, LTF
16palindromic rheumatism31.1MEFV
17myocardial infarction31.0IGES, CHKB, REN, CRP
18fibromuscular dysplasia31.0REN
19acute myocardial infarction31.0CRP, MEFV, CHKB, IGES
20septic arthritis31.0CRP
21rapidly progressive glomerulonephritis30.9MPO, PRTN3
22endocarditis30.9PRTN3
23toxoplasmosis30.9CD40LG
24aortic aneurysm30.9CRP
25glomerulonephritis30.9MPO, PRTN3, CD40LG
26secondary amyloidosis30.8MEFV, CRP
27nephritis30.8APOH, MPO, PRTN3, CD40LG
28prostatitis30.8LTF, KLK3
29rhinitis30.7IGES, IL8
30mixed connective tissue disease30.7APOH, PRTN3
31polymyalgia rheumatica30.6HLA-DRB1, CRP
32hyperthyroidism30.6PRTN3, HLA-DRB1, IGES
33colitis30.6IGES, MPO, IL8, IL6, LTF
34vascular disease30.6FGF2, CRP, PRTN3, APOH
35arthritis30.6IL6, IL8
36hepatitis c30.5HLA-DRB1, GPT, PRTN3, IFNA1, IFNA2, CD40LG
37pancreatitis30.4IGES, MPO, IL6, CRP, LTF
38autoimmune hepatitis30.4HLA-DRB1, GPT, IFNA1, CD40LG
39pneumonia30.3IGES, MPO, IL8, IL6, CRP
40inflammatory bowel disease30.3MPO, IL8, IL6
41myelofibrosis30.3IFNA1, IFNA2, FGF2
42eosinophilia30.3IGES, MPO, PRTN3, IFNA2, IL8
43meningitis30.3IL8, IL6, CRP
44synovitis30.3IL8, IL6, CRP
45primary biliary cirrhosis30.3HLA-DRB1, GPT, PRTN3, CD40LG, LTF
46cryoglobulinemia30.2APOH, IFNA1, IFNA2, CD40LG
47congenital heart disease30.1FGF2, CD40LG, CRP, IL6, MPO
48skin disease30.0HLA-DRB1, MPO, IFNA1, IL6
49myeloma30.0IFNA1, IFNA2, IL6, CD40LG, FGF2
50acute pancreatitis29.9GPT, MPO, IL8, IL6, CRP

Graphical network of the top 20 diseases related to Polyarteritis Nodosa:



Diseases related to polyarteritis nodosa

Symptoms for Polyarteritis Nodosa

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Symptoms:

 47 (show all 60)
  • cutis marmorata/marbled skin/livedo
  • cutaneous rash
  • purpura/petichiae
  • acute abdominal pain/colic
  • asthma/bronchospasm
  • cardiomyopathy/hypertrophic/dilated
  • acute arterial hypertension/hypertensive crisis
  • arterial stenosis/occlusion
  • edema of the legs/lower limbs
  • arterial aneurism (excluding aorta)
  • vascularitis/vasculitides/arteritis
  • acute ischemia of the lower limbs
  • renal disease/nephropathy
  • renal failure
  • testes inflammation/orchitis
  • peripheral neuropathy
  • neuritis/polyneuritis/multineuritis
  • facial pain/cephalalgia/migraine
  • pyramidal syndrome
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic skin infection/ulcerations/ulcers/cancrum
  • urticaria
  • follicular/erythematous/edematous papules/milium
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal perforation
  • hepatitis/icterus/cholestasis
  • cardiac rhythm disorder/arrhythmia
  • angor pectoris/myocardial infarction
  • mesenteric/intestinal infarction
  • gangrena/necrosis
  • seizures/epilepsy/absences/spasms/status epilepticus
  • psychic/behavioural troubles
  • hyperleukocytosis/leukocytosis
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • retinal detachment
  • retinal vascular anomalies/retinal telangiectasia
  • ascitis
  • malabsorption/chronic diarrhea/steatorrhea
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • hemobilia
  • pancreatitis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • heart/cardiac failure
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • arterial embolism/thrombosis
  • acute ischemic syndrome
  • ureteral stenosis/narrowing
  • encephalitis
  • extrapyramidal syndrome
  • myositis
  • osteolysis/osteoclasia/bone destruction/erosions
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • arthritis/synovitis/synovial proliferation
  • autoimmunity/autoimmune reaction/autoantibodies

HPO human phenotypes related to Polyarteritis Nodosa:

(show all 50)
id Description Frequency HPO Source Accession
1 renal insufficiency hallmark (90%) HP:0000083
2 nephropathy hallmark (90%) HP:0000112
3 cutis marmorata hallmark (90%) HP:0000965
4 skin rash hallmark (90%) HP:0000988
5 polyneuropathy hallmark (90%) HP:0001271
6 hypertrophic cardiomyopathy hallmark (90%) HP:0001639
7 weight loss hallmark (90%) HP:0001824
8 subcutaneous hemorrhage hallmark (90%) HP:0001933
9 abdominal pain hallmark (90%) HP:0002027
10 migraine hallmark (90%) HP:0002076
11 asthma hallmark (90%) HP:0002099
12 aneurysm hallmark (90%) HP:0002617
13 vasculitis hallmark (90%) HP:0002633
14 arthralgia hallmark (90%) HP:0002829
15 myalgia hallmark (90%) HP:0003326
16 paresthesia hallmark (90%) HP:0003401
17 abnormality of temperature regulation hallmark (90%) HP:0004370
18 hemiplegia/hemiparesis hallmark (90%) HP:0004374
19 edema of the lower limbs hallmark (90%) HP:0010741
20 hypertensive crisis hallmark (90%) HP:0100735
21 orchitis hallmark (90%) HP:0100796
22 behavioral abnormality typical (50%) HP:0000708
23 urticaria typical (50%) HP:0001025
24 seizures typical (50%) HP:0001250
25 coronary artery disease typical (50%) HP:0001677
26 leukocytosis typical (50%) HP:0001974
27 gastrointestinal hemorrhage typical (50%) HP:0002239
28 gastrointestinal infarctions typical (50%) HP:0005244
29 arrhythmia typical (50%) HP:0011675
30 gangrene typical (50%) HP:0100758
31 skin ulcer typical (50%) HP:0200042
32 ureteral stenosis occasional (7.5%) HP:0000071
33 retinal detachment occasional (7.5%) HP:0000541
34 acrocyanosis occasional (7.5%) HP:0001063
35 arthritis occasional (7.5%) HP:0001369
36 ascites occasional (7.5%) HP:0001541
37 congestive heart failure occasional (7.5%) HP:0001635
38 abnormality of the pericardium occasional (7.5%) HP:0001697
39 pancreatitis occasional (7.5%) HP:0001733
40 malabsorption occasional (7.5%) HP:0002024
41 abnormality of extrapyramidal motor function occasional (7.5%) HP:0002071
42 encephalitis occasional (7.5%) HP:0002383
43 osteomyelitis occasional (7.5%) HP:0002754
44 osteolysis occasional (7.5%) HP:0002797
45 autoimmunity occasional (7.5%) HP:0002960
46 arterial thrombosis occasional (7.5%) HP:0004420
47 abnormality of the retinal vasculature occasional (7.5%) HP:0008046
48 inflammatory abnormality of the eye occasional (7.5%) HP:0100533
49 myositis occasional (7.5%) HP:0100614
50 hemobilia occasional (7.5%) HP:0100762

Drugs & Therapeutics for Polyarteritis Nodosa

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Drug clinical trials:

Search ClinicalTrials for Polyarteritis Nodosa

Search NIH Clinical Center for Polyarteritis Nodosa

Genetic Tests for Polyarteritis Nodosa

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Anatomical Context for Polyarteritis Nodosa

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MalaCards organs/tissues related to Polyarteritis Nodosa:

31
Skin, Kidney, Bone, Heart, Liver, Eye, Testes, Neutrophil, Colon, Lung, Breast, Testis, T cells, Endothelial, Tongue, Spleen, Brain, Prostate, Myeloid, B cells

Animal Models for Polyarteritis Nodosa or affiliated genes

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MGI Mouse Phenotypes related to Polyarteritis Nodosa:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7MPO, CHKB, REN, MEFV, IL6, CRP
2MP:00053976.7FGF2, MPO, PRTN3, REN, ICAM2, MEFV
3MP:00053876.5MPO, PRTN3, REN, ICAM2, MEFV, IL8

Publications for Polyarteritis Nodosa

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Articles related to Polyarteritis Nodosa:

(show top 50)    (show all 646)
idTitleAuthorsYear
1
Polyarteritis nodosa presented as a dilatation of the intrahepatic bile duct. (25368854)
2014
2
Abdominal pain developing from a polyarteritis nodosa-induced hepatic aneurysm. (25599794)
2014
3
Young male patient diagnosed with cutaneous polyarteritis nodosa successfully treated with etanercept. (24981320)
2014
4
Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy. (24552285)
2014
5
Polyarteritis nodosa in childhood: recognition of early dermatologic signs may prevent morbidity. (23937359)
2014
6
Polyarteritis nodosa complicated by posterior reversible encephalopathy syndrome: a case report. (25349926)
2014
7
Necrosis of the tongue as first symptom of Polyarteritis Nodosa (PAN): unusual presentation of a rare disease in children. (21136262)
2013
8
Coronary Artery Bypass Grafting in a Patient with Polyarteritis Nodosa Presenting with Acute Myocardial Infarction and Multiple Coronary Aneurysms. (23995351)
2013
9
Macular arteritis: a pole of the spectrum of cutaneous polyarteritis nodosa? (22995948)
2013
10
Polyarteritis nodosa presenting as acute myocardial infarction in a young man: importance of invasive angiography. (23661639)
2013
11
Remission induced by infliximab in a childhood polyarteritis nodosa refractory to conventional immunosuppression and rituximab. (24388782)
2013
12
Comments on sudden death due to polyarteritis nodosa. (22052059)
2012
13
The usefulness of 3D-CT angiography in polyarteritis nodosa. (22687865)
2012
14
Cutaneous polyarteritis nodosa associated with HLA-B39-positive undifferentiated spondyloarthritis in a Japanese patient. (22270344)
2012
15
Polyarteritis nodosa and SjAPgren's syndrome: overlap syndrome. (20480165)
2012
16
Cutaneous polyarteritis nodosa induced by Mycobacterium tuberculosis. (22035185)
2012
17
Cutaneous polyarteritis nodosa: complete clearance of the leg ulcer after the amputation of the contralateral leg. (21684840)
2011
18
Classic polyarteritis nodosa presenting with rapidly progressive renal insufficiency. (20875386)
2010
19
Acute Myocardial Infarction due to Polyarteritis Nodosa in a Young Female Patient. (20421961)
2010
20
Fulminant polyarteritis nodosa associated with acute myeloid leukaemia resulted in bilateral lower leg amputation. (19553374)
2009
21
Hepatobiliary scintigraphy in vasculitis of the gallbladder as a manifestation of polyarteritis nodosa: a case report. (20062624)
2009
22
Improvement of cutaneous polyarteritis nodosa lesions with hyperbaric oxygen. (19702999)
2009
23
Cutaneous polyarteritis nodosa treated with intravenous immunoglobulins. (18031500)
2008
24
SIR 2006 annual meeting film panel case: polyarteritis nodosa in upper extremity arteries. (17804766)
2007
25
A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. (16575492)
2007
26
A case of recurrent abdominal bleeding due to polyarteritis nodosa despite immunosuppressive therapy. (18092276)
2007
27
Lymphoplasmacytic lymphoma associated with polyradiculoneuritis and cryoglobulinemia mimicking polyarteritis nodosa. (17287105)
2007
28
Polyarteritis nodosa: successful diagnostic imaging utilizing pulsed and color Doppler ultrasonography and computed tomography angiography. (16222527)
2006
29
Hemobilia from ruptured hepatic artery aneurysm in polyarteritis nodosa. (16646571)
2006
30
Polyarteritis nodosa and cryoglobulinemic glomerulonephritis related to chronic hepatitis C. (16775442)
2006
31
Successful pregnancy complicated by microscopic polyarteritis nodosa. (15960155)
2005
32
Short-term corticosteroids then lamivudine and plasma exchanges to treat hepatitis B virus-related polyarteritis nodosa. (15188337)
2004
33
Successful response to infliximab in a patient with undifferentiated spondyloarthropathy coexisting with polyarteritis nodosa-like cutaneous vasculitis. (14740443)
2003
34
A patient with classical polyarteritis nodosa evolving into end stage renal failure. (14669863)
2003
35
Vasculitis: Wegener granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa, and Takayasu arteritis. (12418444)
2002
36
Duodenal necrosis as the presenting manifestation of polyarteritis nodosa. (12189461)
2002
37
Transient and partial effect of high-dose intravenous immunoglobulin in polyarteritis nodosa. (11586025)
2001
38
Treatment of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: where do we stand? (11263763)
2001
39
Hepatitis B-related polyarteritis nodosa complicated by pulmonary hemorrhage. (11348978)
2001
40
Spontaneous perirenal hematoma as the initial manifestation of polyarteritis nodosa and long-term follow-up without treatment. (10867546)
2000
41
Sensory ataxic dominant neuropathy associated with polyarteritis nodosa. (11030213)
2000
42
Childhood polyarteritis nodosa presenting as a relapsing movement disorder. (10685835)
2000
43
A case of cutaneous polyarteritis nodosa associated with ulcerative colitis. (10777260)
2000
44
Early lacunar strokes complicating polyarteritis nodosa: thrombotic microangiopathy. (10690981)
2000
45
Dynamic pattern of endothelial cell adhesion molecule expression in muscle and perineural vessels from patients with classic polyarteritis nodosa. (9506571)
1998
46
Distinct responses of interleukin-6 and other laboratory parameters to treatment in a patient with polyarteritis nodosa--a case report. (1350713)
1992
47
Giant cell (temporal) arteritis following polyarteritis nodosa. (2567193)
1989
48
Cutaneous polyarteritis nodosa. Report of a case associated with Crohn's disease. (6132589)
1983
49
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14144116)
1964
50
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14045124)
1963

Variations for Polyarteritis Nodosa

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Clinvar genetic disease variations for Polyarteritis Nodosa:

6
id Gene Variation Type Significance SNP ID Assembly Location
1CECR1NM_001282227.1(CECR1): c.1232A> G (p.Tyr411Cys)single nucleotide variantPathogenicGRCh37Chr 22, 17662794: 17662794
2CECR1NM_001282227.1(CECR1): c.200C> A (p.Ala67Asp)single nucleotide variantPathogenicGRCh37Chr 22, 17688177: 17688177
3CECR1NM_001282227.1(CECR1): c.14G> C (p.Gly5Ala)single nucleotide variantPathogenicrs200930463GRCh37Chr 22, 17690428: 17690428
4CECR1NM_001282227.1(CECR1): c.210C> G (p.His70Gln)single nucleotide variantPathogenicGRCh37Chr 22, 17688167: 17688167
5CECR1NM_001282227.1(CECR1): c.380G> A (p.Arg127Gln)single nucleotide variantPathogenicrs77563738GRCh37Chr 22, 17687997: 17687997
6CECR1NM_001282227.1(CECR1): c.13G> A (p.Gly5Arg)single nucleotide variantPathogenicGRCh37Chr 22, 17690429: 17690429
7CECR1NM_001282227.1(CECR1): c.626C> T (p.Pro209Leu)single nucleotide variantPathogenicrs148936893GRCh37Chr 22, 17684454: 17684454
8CECR1NM_001282227.1(CECR1): c.14G> T (p.Gly5Val)single nucleotide variantPathogenicrs200930463GRCh37Chr 22, 17690428: 17690428
9CECR1NM_001282227.1(CECR1): c.665G> C (p.Trp222Ser)single nucleotide variantPathogenicGRCh37Chr 22, 17672663: 17672663

Expression for genes affiliated with Polyarteritis Nodosa

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Search GEO for disease gene expression data for Polyarteritis Nodosa.

Pathways for genes affiliated with Polyarteritis Nodosa

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Pathways related to Polyarteritis Nodosa according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway36
9.5MPO, IL6, CRP
2
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.5MPO, IL6, FGF2
3
Show member pathways
9.4MEFV, IL8, IL6
4
Show member pathways
9.4IL8, IFNA2, IFNA1
59.4IL8, IFNA2, IFNA1
69.3CD40LG, IL6, IL8
79.3IFNA1, IFNA2, IL6
8
Show member pathways
9.3IFNA1, IFNA2, IL6
99.3IL6, IFNA2, IFNA1
109.3HLA-DRB1, IL8, IL6
119.0CD40LG, ICAM2, HLA-DRB1
129.0MPO, ICAM2, IL6
139.0IFNA1, IFNA2, IL6, FGF2
14
Show member pathways
9.0HLA-DRB1, IFNA1, IFNA2, IL6
159.0HLA-DRB1, IFNA1, IFNA2, IL6
168.9IL8, IL6, KLK3, FGF2
178.9IL6, IL8, IFNA2, IFNA1
18
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.9IFNA1, IFNA2, IL8, IL6
19
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.9IFNA1, IFNA2, IL8, IL6
20
Show member pathways
8.7HLA-DRB1, IFNA1, IFNA2, IL6, CD40LG
21
Show member pathways
8.6IFNA1, IFNA2, IL8, IL6, CD40LG
22
Show member pathways
8.6FGF2, IL6, IL8, IFNA2, IFNA1
23
Show member pathways
8.5HLA-DRB1, IFNA1, IFNA2, IL8, IL6

Compounds for genes affiliated with Polyarteritis Nodosa

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Compounds related to Polyarteritis Nodosa according to GeneCards Suite gene sharing:

(show top 50)    (show all 254)
idCompoundScoreTop Affiliating Genes
1hydroxychloroquine43 1210.8APOH, CRP, CD40LG, IFNA2
2clarithromycin43 1210.6IL8, LTF, GPT, CHKB
3entecavir439.6IFNA1, GPT, IFNA2
4malondialdehyde439.5GPT, CRP, CHKB, MPO, APOH
5glycyrrhizin43 2810.5LTF, GPT, REN, IFNA1
6erythromycin43 2 49 1212.5MPO, LTF, CD40LG, IFNA2, IL8
7pmma439.4IL6, LTF, CD40LG, CRP
8vitamin b12439.4LTF, CRP, MPO, APOH, GPT, CD40LG
9ribavirin43 49 1211.3LTF, CD40LG, GPT, IFNA2, IFNA1
10ivig439.3IL6, APOH, CRP, GPT, CD40LG
11alpha tocopherol439.3CRP, IFNA2, CHKB, APOH, GPT, KLK3
128-isoprostane439.3APOH, IL8, CRP, IL6, MPO
13etanercept43 49 1211.3IL6, IFNA2, CRP, IL8, APOH
14vitamin a43 24 1211.2CD40LG, IFNA2, CRP, LTF, GPT, FGF2
15polyethylene glycol439.1CHKB, CD40LG, CRP, IFNA2, MPO, IFNA1
16dextran sulfate439.1APOH, KLK3, MPO, CD40LG, LTF, IL6
17pravastatin43 49 28 24 1213.1CD40LG, CHKB, GPT, CRP, IL6
18cyclophosphamide43 49 1211.1MPO, IFNA1, IFNA2, CRP, LTF, APOH
19ascorbic acid43 2410.1CRP, CHKB, MPO, LTF, CD40LG, IFNA2
20il-12439.1CD40LG, IL8, IFNA1, IL6
21imiquimod43 59 28 1212.0IFNA2, IFNA1, IL8, IL6
22thyroxine43 2410.0KLK3, CD40LG, GPT, IFNA2, REN, CHKB
23azathioprine43 2 49 1211.9PRTN3, IFNA2, CHKB, APOH, CRP, LTF
24infliximab43 49 1210.9FGF2, CRP, IFNA2, PRTN3, APOH, IL6
25methacholine43 49 1210.9REN, LTF, CRP, IL8, MPO, IGES
26methotrexate49 43 1210.9APOH, HLA-DRB1, CHKB, CRP, GPT, IL6
27fibrinogen438.9CRP, GPT, APOH, CHKB, IL6, CD40LG
28hydrocortisone43 2 59 1211.8FGF2, IL6, IL8, LTF, KLK3, REN
29latex438.8IGES, LTF, CRP, CHKB, APOH
30thalidomide43 49 59 1211.7IFNA1, IFNA2, FGF2, CD40LG, KLK3, IL6
31aspirin43 49 28 2411.7APOH, KLK3, CRP, IGES, CD40LG, CHKB
32epinephrine43 24 1210.7CHKB, CD40LG, KLK3, REN, IL6, IFNA2
33endotoxin438.6APOH, CHKB, LTF, CRP, IL6, IL8
34superoxide43 249.6PRTN3, APOH, IFNA2, CHKB, LTF, IL8
35heparin43 28 24 1211.6IL8, FGF2, APOH, CD40LG, MPO, CHKB
36n acetylcysteine438.5LTF, IL6, IL8, MPO, GPT, CRP
37pge2438.5FGF2, REN, CHKB, IL8, MPO, LTF
38histamine43 28 2410.4LTF, CD40LG, IL6, IL8, IGES, IFNA2
39creatinine438.4REN, CHKB, MPO, IL6, APOH, GPT
40rituximab43 49 1210.4APOH, CD40LG, CRP, IL6, IFNA2, IFNA1
41prednisolone43 28 1210.2IFNA2, GPT, APOH, MPO, CHKB, IFNA1
42aspartate438.2IFNA2, GPT, CD40LG, LTF, CHKB, CRP
43hyaluronic acid43 249.1IL8, KLK3, CD40LG, LTF, IL6, GPT
44neopterin438.0CD40LG, GPT, IFNA1, IFNA2, IL8, IL6
45estrogen437.9KLK3, CHKB, APOH, FGF2, LTF, CD40LG
46dexamethasone43 49 28 1210.8IL8, IL6, FGF2, LTF, CD40LG, KLK3
47cyclosporin a43 28 599.6FGF2, LTF, IGES, GPT, CHKB, IFNA1
48lactate437.5IL8, CHKB, MPO, APOH, GPT, IGES
49alanine437.2HLA-DRB1, CD40LG, IFNA1, IL6, FGF2, CRP
50vegf436.9APOH, MPO, IFNA2, IL8, IL6, CRP

GO Terms for genes affiliated with Polyarteritis Nodosa

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Cellular components related to Polyarteritis Nodosa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.9IFNA2, IL8, IL6, CRP, KLK3, LTF
2extracellular spaceGO:00056157.1FGF2, APOH, MPO, REN, CECR1, IFNA2

Biological processes related to Polyarteritis Nodosa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:00108889.6CRP, IL6
2response to lipopolysaccharideGO:00324969.5IL6, REN, MPO
3positive regulation of osteoblast differentiationGO:00456699.5IL6, LTF, FGF2
4agingGO:00075689.2CRP, IL6, MPO
5inflammatory responseGO:00069548.7CD40LG, CRP, IL6, IL8, IFNA2, MEFV

Molecular functions related to Polyarteritis Nodosa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.2FGF2, CD40LG, IL6, IFNA2
2heparin bindingGO:00082019.0FGF2, LTF, CECR1, MPO, APOH

Products for genes affiliated with Polyarteritis Nodosa

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  • Antibodies
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Sources for Polyarteritis Nodosa

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet