MCID: PLY017
MIFTS: 69

Polyarteritis Nodosa malady

Rare diseases, Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases categories

Summaries for Polyarteritis Nodosa

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NIH Rare Diseases:43 Polyarteritis nodosa is a serious blood vessel disease in which medium-sized arteries become swollen and damaged. it occurs when certain immune cells attack the affected arteries preventing vital oxygen and nourishment. signs and symptoms may include fever, fatigue, weakness, loss of appetite, weight loss, muscle and joint aches, and abdominal pain. the skin may show rashes, swelling, ulcers, and lumps. when nerve cells are involved numbness, pain, burning, and weakness may be present. polyarteritis nodosa can cause serious health complications including strokes, seizures, and kidney failure. treatment often includes steroids and other drugs to suppress the immune system. last updated: 1/16/2012

MalaCards based summary: Polyarteritis Nodosa, also known as periarteritis nodosa, is related to hepatitis and vasculitis, and has symptoms including renal insufficiency, nephropathy and cutis marmorata. An important gene associated with Polyarteritis Nodosa is CECR1 (cat eye syndrome chromosome region, candidate 1), and among its related pathways are Selenium Pathway and Immune response IL 23 signaling pathway. The compounds hydroxychloroquine and clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and bone, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Wikipedia:65 Polyarteritis nodosa, also known as panarteritis nodosa,periarteritis nodosa,), Kussmaul disease or... more...

Aliases & Classifications for Polyarteritis Nodosa

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Sources:
10Disease Ontology, 43NIH Rare Diseases, 12DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 57SNOMED-CT, 35MeSH, 29ICD9CM, 40NCIt, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Polyarteritis Nodosa, Aliases & Descriptions:

Name: Polyarteritis Nodosa 10 43 12 45 49 62
Periarteritis Nodosa 43 49 62
 
K├╝ssmaul-Maier Disease 43 49
Pan 43


Classifications:



Characteristics (Orphanet epidemiological data):

49
polyarteritis nodosa:
Inheritance: Autosomal recessive,Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Disease Ontology10 DOID:9810
MeSH35 D010488
ICD9CM29 446.0
NCIt40 C26847
Orphanet49 767
MESH via Orphanet36 D010488
ICD10 via Orphanet28 M30.0
UMLS via Orphanet63 C0031036
ICD1027 M30.0

Related Diseases for Polyarteritis Nodosa

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Diseases related to Polyarteritis Nodosa via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 333)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.5CD40LG, IFNA2, GPT, IFNA1
2vasculitis31.3MEFV, PRTN3, MPO, APOH, LTF, CD40LG
3hepatitis b31.3GPT, LTF, IFNA1, IFNA2, HLA-DRB1
4churg-strauss syndrome31.2LTF, PRTN3, MPO
5crohn's disease30.9LTF, CRP
6myocardial infarction30.9REN, IGES, CHKB, CRP
7hepatitis c30.9IFNA2, PRTN3, GPT, HLA-DRB1, IFNA1, CD40LG
8arthritis30.8IL6, IL8
9mononeuritis multiplex30.8MPO, PRTN3
10colitis30.8IGES, MPO, IL8, IL6, LTF
11ulcerative colitis30.7LTF, CRP, PRTN3
12acute myocardial infarction30.7IGES, CHKB, CRP, MEFV
13retinal artery occlusion30.7APOH
14sneddon syndrome30.7APOH
15retinal vasculitis30.7APOH
16thrombophlebitis30.7APOH
17sinusitis30.6IGES, PRTN3
18leukemia30.5IFNA1, IFNA2, CD40LG, FGF2, IL6, ICAM2
19cholecystitis30.5GPT
20autoimmune hepatitis30.5IFNA1, GPT, CD40LG, HLA-DRB1
21pneumonia30.5IL8, IL6, CRP, IGES, MPO
22adult-onset still's disease30.5CRP
23lupus erythematosus30.5IFNA2, APOH
24glomerulonephritis30.5MPO, CD40LG, PRTN3
25nephritis30.5CD40LG, APOH, MPO, PRTN3
26vascular disease30.5PRTN3, CRP, APOH, FGF2
27pancreatitis30.4IL6, CRP, LTF, MPO, IGES
28myeloma30.4FGF2, CD40LG, IL6, IFNA2, IFNA1
29aortic aneurysm30.3CRP
30secondary amyloidosis30.3MEFV, CRP
31palindromic rheumatism30.3MEFV
32rhinitis30.3IGES, IL8
33fibromuscular dysplasia30.3REN
34septic arthritis30.3CRP
35rapidly progressive glomerulonephritis30.3PRTN3, MPO
36hyperthyroidism30.3PRTN3, IGES, HLA-DRB1
37toxoplasmosis30.3CD40LG
38endocarditis30.3PRTN3
39prostatitis30.3LTF, KLK3
40mixed connective tissue disease30.3PRTN3, APOH
41polymyalgia rheumatica30.3CRP, HLA-DRB1
42meningitis30.2CRP, IL8, IL6
43synovitis30.2CRP, IL8, IL6
44congenital heart disease30.2CRP, FGF2, MPO, IL6, CD40LG
45inflammatory bowel disease30.2IL6, IL8, MPO
46myelofibrosis30.2IFNA1, FGF2, IFNA2
47eosinophilia30.2PRTN3, IGES, MPO, IL8, IFNA2
48skin disease30.2HLA-DRB1, IFNA1, IL6, MPO
49primary biliary cirrhosis30.2HLA-DRB1, LTF, GPT, PRTN3, CD40LG
50cryoglobulinemia30.2IFNA1, IFNA2, CD40LG, APOH

Graphical network of the top 20 diseases related to Polyarteritis Nodosa:



Diseases related to polyarteritis nodosa

Symptoms for Polyarteritis Nodosa

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Symptoms:

 49 (show all 60)
  • cutis marmorata/marbled skin/livedo
  • cutaneous rash
  • purpura/petichiae
  • acute abdominal pain/colic
  • asthma/bronchospasm
  • cardiomyopathy/hypertrophic/dilated
  • acute arterial hypertension/hypertensive crisis
  • arterial stenosis/occlusion
  • edema of the legs/lower limbs
  • arterial aneurism (excluding aorta)
  • vascularitis/vasculitides/arteritis
  • acute ischemia of the lower limbs
  • renal disease/nephropathy
  • renal failure
  • testes inflammation/orchitis
  • peripheral neuropathy
  • neuritis/polyneuritis/multineuritis
  • facial pain/cephalalgia/migraine
  • pyramidal syndrome
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic skin infection/ulcerations/ulcers/cancrum
  • urticaria
  • follicular/erythematous/edematous papules/milium
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal perforation
  • hepatitis/icterus/cholestasis
  • cardiac rhythm disorder/arrhythmia
  • angor pectoris/myocardial infarction
  • mesenteric/intestinal infarction
  • gangrena/necrosis
  • seizures/epilepsy/absences/spasms/status epilepticus
  • psychic/behavioural troubles
  • hyperleukocytosis/leukocytosis
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • retinal detachment
  • retinal vascular anomalies/retinal telangiectasia
  • ascitis
  • malabsorption/chronic diarrhea/steatorrhea
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • hemobilia
  • pancreatitis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • heart/cardiac failure
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • arterial embolism/thrombosis
  • acute ischemic syndrome
  • ureteral stenosis/narrowing
  • encephalitis
  • extrapyramidal syndrome
  • myositis
  • osteolysis/osteoclasia/bone destruction/erosions
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • arthritis/synovitis/synovial proliferation
  • autoimmunity/autoimmune reaction/autoantibodies

HPO human phenotypes related to Polyarteritis Nodosa:

(show all 50)
id Description Frequency HPO Source Accession
1 renal insufficiency hallmark (90%) HP:0000083
2 nephropathy hallmark (90%) HP:0000112
3 cutis marmorata hallmark (90%) HP:0000965
4 skin rash hallmark (90%) HP:0000988
5 polyneuropathy hallmark (90%) HP:0001271
6 hypertrophic cardiomyopathy hallmark (90%) HP:0001639
7 weight loss hallmark (90%) HP:0001824
8 subcutaneous hemorrhage hallmark (90%) HP:0001933
9 abdominal pain hallmark (90%) HP:0002027
10 migraine hallmark (90%) HP:0002076
11 asthma hallmark (90%) HP:0002099
12 aneurysm hallmark (90%) HP:0002617
13 vasculitis hallmark (90%) HP:0002633
14 arthralgia hallmark (90%) HP:0002829
15 myalgia hallmark (90%) HP:0003326
16 paresthesia hallmark (90%) HP:0003401
17 abnormality of temperature regulation hallmark (90%) HP:0004370
18 hemiplegia/hemiparesis hallmark (90%) HP:0004374
19 edema of the lower limbs hallmark (90%) HP:0010741
20 hypertensive crisis hallmark (90%) HP:0100735
21 orchitis hallmark (90%) HP:0100796
22 behavioral abnormality typical (50%) HP:0000708
23 urticaria typical (50%) HP:0001025
24 seizures typical (50%) HP:0001250
25 coronary artery disease typical (50%) HP:0001677
26 leukocytosis typical (50%) HP:0001974
27 gastrointestinal hemorrhage typical (50%) HP:0002239
28 gastrointestinal infarctions typical (50%) HP:0005244
29 arrhythmia typical (50%) HP:0011675
30 gangrene typical (50%) HP:0100758
31 skin ulcer typical (50%) HP:0200042
32 ureteral stenosis occasional (7.5%) HP:0000071
33 retinal detachment occasional (7.5%) HP:0000541
34 acrocyanosis occasional (7.5%) HP:0001063
35 arthritis occasional (7.5%) HP:0001369
36 ascites occasional (7.5%) HP:0001541
37 congestive heart failure occasional (7.5%) HP:0001635
38 abnormality of the pericardium occasional (7.5%) HP:0001697
39 pancreatitis occasional (7.5%) HP:0001733
40 malabsorption occasional (7.5%) HP:0002024
41 abnormality of extrapyramidal motor function occasional (7.5%) HP:0002071
42 encephalitis occasional (7.5%) HP:0002383
43 osteomyelitis occasional (7.5%) HP:0002754
44 osteolysis occasional (7.5%) HP:0002797
45 autoimmunity occasional (7.5%) HP:0002960
46 arterial thrombosis occasional (7.5%) HP:0004420
47 abnormality of the retinal vasculature occasional (7.5%) HP:0008046
48 inflammatory abnormality of the eye occasional (7.5%) HP:0100533
49 myositis occasional (7.5%) HP:0100614
50 hemobilia occasional (7.5%) HP:0100762

Drugs & Therapeutics for Polyarteritis Nodosa

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Drug clinical trials:

Search ClinicalTrials for Polyarteritis Nodosa

Search NIH Clinical Center for Polyarteritis Nodosa

Genetic Tests for Polyarteritis Nodosa

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Anatomical Context for Polyarteritis Nodosa

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MalaCards organs/tissues related to Polyarteritis Nodosa:

33
Skin, Kidney, Bone, Heart, Liver, Eye, Testes, Neutrophil, Colon, Lung, Breast, Testis, T cells, Endothelial, Tongue, Spleen, Brain, Prostate, Myeloid, B cells

Animal Models for Polyarteritis Nodosa or affiliated genes

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MGI Mouse Phenotypes related to Polyarteritis Nodosa:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7LTF, CD40LG, CRP, IL6, MEFV, REN
2MP:00053976.7MPO, FGF2, LTF, CD40LG, IL6, IL8
3MP:00053876.5MPO, PRTN3, REN, ICAM2, MEFV, IL8

Publications for Polyarteritis Nodosa

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Articles related to Polyarteritis Nodosa:

(show top 50)    (show all 646)
idTitleAuthorsYear
1
Polyarteritis nodosa presented as a dilatation of the intrahepatic bile duct. (25368854)
2014
2
Abdominal pain developing from a polyarteritis nodosa-induced hepatic aneurysm. (25599794)
2014
3
Young male patient diagnosed with cutaneous polyarteritis nodosa successfully treated with etanercept. (24981320)
2014
4
Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy. (24552285)
2014
5
Polyarteritis nodosa in childhood: recognition of early dermatologic signs may prevent morbidity. (23937359)
2014
6
Polyarteritis nodosa complicated by posterior reversible encephalopathy syndrome: a case report. (25349926)
2014
7
Necrosis of the tongue as first symptom of Polyarteritis Nodosa (PAN): unusual presentation of a rare disease in children. (21136262)
2013
8
Coronary Artery Bypass Grafting in a Patient with Polyarteritis Nodosa Presenting with Acute Myocardial Infarction and Multiple Coronary Aneurysms. (23995351)
2013
9
Macular arteritis: a pole of the spectrum of cutaneous polyarteritis nodosa? (22995948)
2013
10
Polyarteritis nodosa presenting as acute myocardial infarction in a young man: importance of invasive angiography. (23661639)
2013
11
Remission induced by infliximab in a childhood polyarteritis nodosa refractory to conventional immunosuppression and rituximab. (24388782)
2013
12
Comments on sudden death due to polyarteritis nodosa. (22052059)
2012
13
The usefulness of 3D-CT angiography in polyarteritis nodosa. (22687865)
2012
14
Cutaneous polyarteritis nodosa associated with HLA-B39-positive undifferentiated spondyloarthritis in a Japanese patient. (22270344)
2012
15
Polyarteritis nodosa and SjAPgren's syndrome: overlap syndrome. (20480165)
2012
16
Cutaneous polyarteritis nodosa induced by Mycobacterium tuberculosis. (22035185)
2012
17
Cutaneous polyarteritis nodosa: complete clearance of the leg ulcer after the amputation of the contralateral leg. (21684840)
2011
18
Classic polyarteritis nodosa presenting with rapidly progressive renal insufficiency. (20875386)
2010
19
Acute Myocardial Infarction due to Polyarteritis Nodosa in a Young Female Patient. (20421961)
2010
20
Fulminant polyarteritis nodosa associated with acute myeloid leukaemia resulted in bilateral lower leg amputation. (19553374)
2009
21
Hepatobiliary scintigraphy in vasculitis of the gallbladder as a manifestation of polyarteritis nodosa: a case report. (20062624)
2009
22
Improvement of cutaneous polyarteritis nodosa lesions with hyperbaric oxygen. (19702999)
2009
23
Cutaneous polyarteritis nodosa treated with intravenous immunoglobulins. (18031500)
2008
24
SIR 2006 annual meeting film panel case: polyarteritis nodosa in upper extremity arteries. (17804766)
2007
25
A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. (16575492)
2007
26
A case of recurrent abdominal bleeding due to polyarteritis nodosa despite immunosuppressive therapy. (18092276)
2007
27
Lymphoplasmacytic lymphoma associated with polyradiculoneuritis and cryoglobulinemia mimicking polyarteritis nodosa. (17287105)
2007
28
Polyarteritis nodosa: successful diagnostic imaging utilizing pulsed and color Doppler ultrasonography and computed tomography angiography. (16222527)
2006
29
Hemobilia from ruptured hepatic artery aneurysm in polyarteritis nodosa. (16646571)
2006
30
Polyarteritis nodosa and cryoglobulinemic glomerulonephritis related to chronic hepatitis C. (16775442)
2006
31
Successful pregnancy complicated by microscopic polyarteritis nodosa. (15960155)
2005
32
Short-term corticosteroids then lamivudine and plasma exchanges to treat hepatitis B virus-related polyarteritis nodosa. (15188337)
2004
33
Successful response to infliximab in a patient with undifferentiated spondyloarthropathy coexisting with polyarteritis nodosa-like cutaneous vasculitis. (14740443)
2003
34
A patient with classical polyarteritis nodosa evolving into end stage renal failure. (14669863)
2003
35
Vasculitis: Wegener granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa, and Takayasu arteritis. (12418444)
2002
36
Duodenal necrosis as the presenting manifestation of polyarteritis nodosa. (12189461)
2002
37
Transient and partial effect of high-dose intravenous immunoglobulin in polyarteritis nodosa. (11586025)
2001
38
Treatment of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: where do we stand? (11263763)
2001
39
Hepatitis B-related polyarteritis nodosa complicated by pulmonary hemorrhage. (11348978)
2001
40
Spontaneous perirenal hematoma as the initial manifestation of polyarteritis nodosa and long-term follow-up without treatment. (10867546)
2000
41
Sensory ataxic dominant neuropathy associated with polyarteritis nodosa. (11030213)
2000
42
Childhood polyarteritis nodosa presenting as a relapsing movement disorder. (10685835)
2000
43
A case of cutaneous polyarteritis nodosa associated with ulcerative colitis. (10777260)
2000
44
Early lacunar strokes complicating polyarteritis nodosa: thrombotic microangiopathy. (10690981)
2000
45
Dynamic pattern of endothelial cell adhesion molecule expression in muscle and perineural vessels from patients with classic polyarteritis nodosa. (9506571)
1998
46
Distinct responses of interleukin-6 and other laboratory parameters to treatment in a patient with polyarteritis nodosa--a case report. (1350713)
1992
47
Giant cell (temporal) arteritis following polyarteritis nodosa. (2567193)
1989
48
Cutaneous polyarteritis nodosa. Report of a case associated with Crohn's disease. (6132589)
1983
49
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14144116)
1964
50
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14045124)
1963

Variations for Polyarteritis Nodosa

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Clinvar genetic disease variations for Polyarteritis Nodosa:

7
id Gene Variation Type Significance SNP ID Assembly Location
1CECR1NM_001282227.1(CECR1): c.1232A> G (p.Tyr411Cys)single nucleotide variantPathogenicGRCh37Chr 22, 17662794: 17662794
2CECR1NM_001282227.1(CECR1): c.200C> A (p.Ala67Asp)single nucleotide variantPathogenicGRCh37Chr 22, 17688177: 17688177
3CECR1NM_001282227.1(CECR1): c.14G> C (p.Gly5Ala)single nucleotide variantPathogenicrs200930463GRCh37Chr 22, 17690428: 17690428
4CECR1NM_001282227.1(CECR1): c.210C> G (p.His70Gln)single nucleotide variantPathogenicGRCh37Chr 22, 17688167: 17688167
5CECR1NM_001282227.1(CECR1): c.380G> A (p.Arg127Gln)single nucleotide variantPathogenicrs77563738GRCh37Chr 22, 17687997: 17687997
6CECR1NM_001282227.1(CECR1): c.13G> A (p.Gly5Arg)single nucleotide variantPathogenicGRCh37Chr 22, 17690429: 17690429
7CECR1NM_001282227.1(CECR1): c.626C> T (p.Pro209Leu)single nucleotide variantPathogenicrs148936893GRCh37Chr 22, 17684454: 17684454
8CECR1NM_001282227.1(CECR1): c.14G> T (p.Gly5Val)single nucleotide variantPathogenicrs200930463GRCh37Chr 22, 17690428: 17690428
9CECR1NM_001282227.1(CECR1): c.665G> C (p.Trp222Ser)single nucleotide variantPathogenicGRCh37Chr 22, 17672663: 17672663

Expression for genes affiliated with Polyarteritis Nodosa

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Search GEO for disease gene expression data for Polyarteritis Nodosa.

Pathways for genes affiliated with Polyarteritis Nodosa

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Pathways related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway38
9.5IL6, CRP, MPO
2
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.5IL6, FGF2, MPO
3
Show member pathways
9.4IL6, IL8, MEFV
4
Show member pathways
9.4IFNA1, IFNA2, IL8
59.4IL8, IFNA2, IFNA1
69.3CD40LG, IL6, IL8
7
Show member pathways
9.3IFNA2, IL6, IFNA1
89.3IFNA1, IFNA2, IL6
99.3IL6, IFNA2, IFNA1
109.3IL6, IL8, HLA-DRB1
119.0ICAM2, HLA-DRB1, CD40LG
129.0MPO, IL6, ICAM2
139.0IFNA1, FGF2, IL6, IFNA2
149.0IFNA1, IL6, IFNA2, HLA-DRB1
15
Show member pathways
9.0HLA-DRB1, IFNA2, IL6, IFNA1
168.9FGF2, KLK3, IL6, IL8
178.9IL8, IL6, IFNA2, IFNA1
18
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.9IFNA1, IL6, IL8, IFNA2
19
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.9IFNA1, IFNA2, IL6, IL8
20
Show member pathways
8.7IFNA2, IL6, CD40LG, HLA-DRB1, IFNA1
21
Show member pathways
8.6IFNA2, IL8, IL6, CD40LG, IFNA1
22
Show member pathways
8.6FGF2, IL6, IL8, IFNA2, IFNA1
23
Show member pathways
8.5IL8, IL6, IFNA2, HLA-DRB1, IFNA1

Compounds for genes affiliated with Polyarteritis Nodosa

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Compounds related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

(show top 50)    (show all 254)
idCompoundScoreTop Affiliating Genes
1hydroxychloroquine45 1310.8APOH, CRP, CD40LG, IFNA2
2clarithromycin45 1310.6IL8, LTF, GPT, CHKB
3entecavir459.6IFNA1, GPT, IFNA2
4malondialdehyde459.5GPT, CRP, CHKB, MPO, APOH
5glycyrrhizin45 3010.5LTF, GPT, REN, IFNA1
6erythromycin45 3 51 1312.5MPO, LTF, CD40LG, IFNA2, IL8
7pmma459.4IL6, LTF, CD40LG, CRP
8vitamin b12459.4LTF, CRP, MPO, APOH, GPT, CD40LG
9ribavirin45 51 1311.3LTF, CD40LG, GPT, IFNA2, IFNA1
10ivig459.3IL6, APOH, CRP, GPT, CD40LG
11alpha tocopherol459.3CRP, IFNA2, CHKB, APOH, GPT, KLK3
128-isoprostane459.3APOH, IL8, CRP, IL6, MPO
13etanercept45 51 1311.3IL6, IFNA2, CRP, IL8, APOH
14vitamin a45 26 1311.2CD40LG, IFNA2, CRP, LTF, GPT, FGF2
15polyethylene glycol459.1CHKB, CD40LG, CRP, IFNA2, MPO, IFNA1
16dextran sulfate459.1APOH, KLK3, MPO, CD40LG, LTF, IL6
17pravastatin45 51 30 26 1313.1CD40LG, CHKB, GPT, CRP, IL6
18cyclophosphamide45 51 1311.1MPO, IFNA1, IFNA2, CRP, LTF, APOH
19ascorbic acid45 2610.1CRP, CHKB, MPO, LTF, CD40LG, IFNA2
20il-12459.1CD40LG, IL8, IFNA1, IL6
21imiquimod45 61 30 1312.0IFNA2, IFNA1, IL8, IL6
22thyroxine45 2610.0KLK3, CD40LG, GPT, IFNA2, REN, CHKB
23azathioprine45 3 51 1311.9PRTN3, IFNA2, CHKB, APOH, CRP, LTF
24infliximab45 51 1310.9FGF2, CRP, IFNA2, PRTN3, APOH, IL6
25methacholine45 51 1310.9REN, LTF, CRP, IL8, MPO, IGES
26methotrexate51 45 1310.9APOH, HLA-DRB1, CHKB, CRP, GPT, IL6
27fibrinogen458.9CRP, GPT, APOH, CHKB, IL6, CD40LG
28hydrocortisone45 3 61 1311.8FGF2, IL6, IL8, LTF, KLK3, REN
29latex458.8IGES, LTF, CRP, CHKB, APOH
30thalidomide45 51 61 1311.7IFNA1, IFNA2, FGF2, CD40LG, KLK3, IL6
31aspirin45 51 30 2611.7APOH, KLK3, CRP, IGES, CD40LG, CHKB
32epinephrine45 26 1310.7CHKB, CD40LG, KLK3, REN, IL6, IFNA2
33endotoxin458.6APOH, CHKB, LTF, CRP, IL6, IL8
34superoxide45 269.6PRTN3, APOH, IFNA2, CHKB, LTF, IL8
35heparin45 30 26 1311.6IL8, FGF2, APOH, CD40LG, MPO, CHKB
36n acetylcysteine458.5LTF, IL6, IL8, MPO, GPT, CRP
37pge2458.5FGF2, REN, CHKB, IL8, MPO, LTF
38histamine45 30 2610.4LTF, CD40LG, IL6, IL8, IGES, IFNA2
39creatinine458.4REN, CHKB, MPO, IL6, APOH, GPT
40rituximab45 51 1310.4APOH, CD40LG, CRP, IL6, IFNA2, IFNA1
41prednisolone45 30 1310.2IFNA2, GPT, APOH, MPO, CHKB, IFNA1
42aspartate458.2IFNA2, GPT, CD40LG, LTF, CHKB, CRP
43hyaluronic acid45 269.1IL8, KLK3, CD40LG, LTF, IL6, GPT
44neopterin458.0CD40LG, GPT, IFNA1, IFNA2, IL8, IL6
45estrogen457.9KLK3, CHKB, APOH, FGF2, LTF, CD40LG
46dexamethasone45 51 30 1310.8IL8, IL6, FGF2, LTF, CD40LG, KLK3
47cyclosporin a45 30 619.6FGF2, LTF, IGES, GPT, CHKB, IFNA1
48lactate457.5IL8, CHKB, MPO, APOH, GPT, IGES
49alanine457.2HLA-DRB1, CD40LG, IFNA1, IL6, FGF2, CRP
50vegf456.9APOH, MPO, IFNA2, IL8, IL6, CRP

GO Terms for genes affiliated with Polyarteritis Nodosa

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Cellular components related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.9REN, IFNA2, IL8, IL6, CRP, KLK3
2extracellular spaceGO:00056157.1APOH, MPO, REN, CECR1, IFNA2, IL8

Biological processes related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:00108889.6CRP, IL6
2response to lipopolysaccharideGO:00324969.5IL6, REN, MPO
3positive regulation of osteoblast differentiationGO:00456699.5IL6, LTF, FGF2
4agingGO:00075689.2CRP, IL6, MPO
5inflammatory responseGO:00069548.7CD40LG, CRP, IL6, IL8, IFNA2, MEFV

Molecular functions related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.2FGF2, CD40LG, IL6, IFNA2
2heparin bindingGO:00082019.0FGF2, LTF, CECR1, MPO, APOH

Products for genes affiliated with Polyarteritis Nodosa

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Sources for Polyarteritis Nodosa

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet