Polyarteritis Nodosa malady

NIH Rare Diseases: Polyarteritis nodosa is a serious blood vessel disease in which medium-sized arteries become swollen and damaged. It occurs when certain immune cells attack the affected arteries preventing vital oxygen and nourishment. Signs and symptoms may include fever, fatigue, weakness, loss of appetite, weight loss, muscle and joint aches, and abdominal pain. The skin may show rashes, swelling, ulcers, and lumps. When nerve cells are involved numbness, pain, burning, and weakness may be present. Polyarteritis nodosa can cause serious health complications including strokes, seizures, and kidney failure. Treatment often includes steroids and other drugs to suppress the immune system.³⁰

MalaCards: Polyarteritis Nodosa, also known as PAN, is related to hepatitis and hepatitis b. An important gene associated with Polyarteritis Nodosa is IFNA2 (interferon, alpha 2), and among its related pathways are all-trans-Retinoic Acid Mediated Apoptosis and Autoimmune thyroid disease. The compounds cyclophosphamide and polyethylene glycol have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and prostate, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia: Polyarteritis nodosa (also known as \"Panarteritis nodosa\" and \"Periarteritis nodosa\") is a...⁴⁴ more...

Aliases & Descriptions:

polyarteritis nodosa 6 30 8 32 43 pan 30

Diseases related to polyarteritis nodosa by text searches and GeneDecks gene sharing:

(show top 50)    (show all 540)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis	33.7	GPT, IFNA1
2	hepatitis b	33.1	GPT, IFNA1, IFNA2
3	microscopic polyangiitis	30.4	MPO, CRP, PRTN3
4	familial mediterranean fever	30.0	MEFV, IL6, IL8, APOH, CRP
5	polymyositis	29.5	CHKB, IFNA1, IFNA2, CRP
6	churg-strauss syndrome	29.4	MPO, IFNA1, CRP, LTF, PRTN3
7	hepatitis c	29.3	CD40LG, GPT, IFNA1, IFNA2, LTF
8	wegener's granulomatosis	28.4	MPO, IL6, IL8, APOH, CRP, PRTN3
9	polyneuropathy	28.3	CD40LG, IL6, GPT, IFNA1, IFNA2, CRP
10	eosinophilia	28.2	REN, MPO, IL6, IL8, IGES, IFNA2
11	headache	26.4	CD40LG, IL6, APOH, PRTN3
12	focal segmental glomerulosclerosis	26.1	IL6, IFNA1, IFNA2
13	pancreatic cancer	26.1	REN, FGF2, IL6, IL8, GPT, IFNA1
14	hypertension	25.4	REN, MPO, CD40LG, FGF2, IL6, IL8
15	vasculitis	25.2	REN, MPO, CD40LG, FGF2, MEFV, IL6
16	leukemia/lymphoma	25.1	MPO, CD40LG, FGF2, IL6, IFNA1, IFNA2
17	kaposi's sarcoma	24.7	FGF2, IL6, IL8, IFNA1, IFNA2
18	pancreatitis	24.7	REN, CHKB, MPO, CD40LG, FGF2, IL6
19	esophageal cancer	24.5	MPO, FGF2, IL6, GPT, IFNA1, IFNA2
20	prostatitis	24.0	MPO, CD40LG, FGF2, MEFV, IL6, IL8
21	acute lymphoblastic leukemia	23.5	CHKB, MPO, CD40LG, IL6, IL8, APOH
22	lymphocytic leukemia	23.5	MPO, CD40LG, FGF2, IL6, IL8, IFNA1
23	lymphoblastic leukemia	23.5	CHKB, MPO, CD40LG, IL6, IL8, APOH
24	neuronitis	23.4	REN, CHKB, MPO, CD40LG, FGF2, IL6
25	acute myeloid leukemia	23.3	REN, MPO, FGF2, IL6, IL8, GPT
26	myeloid leukemia	23.3	REN, MPO, FGF2, IL6, IL8, GPT
27	bronchiolitis	23.2	CHKB, MPO, CD40LG, IL6, IL8, IGES
28	nephritis	23.0	REN, MPO, CD40LG, IL6, IL8, APOH
29	acute pancreatitis	22.9	CHKB, MPO, CD40LG, IL6, IL8, APOH
30	hepatocellular carcinoma	22.9	CHKB, MPO, FGF2, IL6, IL8, GPT
31	atherosclerosis	22.9	REN, MPO, CD40LG, FGF2, IL6, IL8
32	ovarian carcinoma	22.9	FGF2, IL6, IL8, IFNA1, IFNA2, KLK3
33	carcinoma	22.9	REN, CHKB, MPO, CD40LG, FGF2, IL6
34	esophagitis	22.8	MPO, FGF2, IL6, IL8, GPT, IGES
35	multiple myeloma	22.7	MPO, CD40LG, FGF2, IL6, IL8, APOH
36	myeloma	22.7	MPO, CD40LG, FGF2, IL6, IL8, APOH
37	retinitis	22.4	CD40LG, FGF2, IL6, IL8, APOH, GPT
38	ovarian cancer	22.2	MPO, FGF2, IL6, IL8, GPT, IFNA1
39	rheumatoid arthritis	22.0	CHKB, MPO, CD40LG, FGF2, MEFV, IL6
40	arthritis	22.0	CHKB, MPO, CD40LG, FGF2, MEFV, IL6
41	hodgkin's lymphoma	22.0	CHKB, MPO, CD40LG, FGF2, IL6, IL8
42	sarcoma	21.8	REN, CHKB, MPO, CD40LG, FGF2, IL6
43	adenocarcinoma	21.3	CHKB, MPO, CD40LG, FGF2, IL6, IL8
44	fibrosis	21.2	REN, MPO, CD40LG, FGF2, IL6, IL8
45	breast cancer	21.2	CHKB, MPO, CD40LG, FGF2, IL6, IL8
46	leukemia	20.9	REN, CHKB, MPO, CD40LG, FGF2, MEFV
47	glomerulonephritis	20.9	REN, MPO, CD40LG, FGF2, MEFV, IL6
48	squamous cell carcinoma	20.9	CHKB, MPO, FGF2, IL6, IL8, GPT
49	galactosemia	20.7	REN, CHKB, MPO, CD40LG, FGF2, IL6
50	non-hodgkin lymphoma	20.6	CHKB, MPO, CD40LG, FGF2, IL6, IL8

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to polyarteritis nodosa:

²²

MGI Mouse Phenotypes related to polyarteritis nodosa:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.2	FGF2, MEFV, ICAM2, DFFB
2	immune system phenotype	MP:0005387	8.2	REN, CPN1, PRTN3, DFFB, LTF, IL6

Articles related to polyarteritis nodosa:

(show all 28)

id	Title	Authors	Year	Affiliating Genes
1	Aneurysms of the renal arteries associated with segmental arterial mediolysis in a case of polyarteritis nodosa. (19261100)	Soga Y.... Furuya K.	2009	CRP
2	Polyarteritis nodosa complicated by antiphospholipid syndrome. (18360325)	Musuruana J.L.... Cavallasca J.A.	2008	APOH
3	Necrotizing vasculitis with a polyarteritis nodosa-like pattern and selective immunoglobulin A deficiency: case report and review of the literature. (18494827)	Paradela S.... Fonseca E.	2008	CD40LG
4	Multiple visceral hematomas in a child with familial Mediterranean fever: polyarteritis nodosa. (18183427)	Baysun S.... Oner A.	2008	MEFV
5	Prevalence of the MEFV gene mutations in childhood polyarteritis nodosa. (18035151)	Yalcinkaya F.... Ozen S.	2007	MEFV
6	Angiogenic cytokines in serum and cutaneous lesions of patients with polyarteritis nodosa. (15965421)	Kikuchi K.... Tamaki K.	2005	FGF2
7	Treatment of hepatitis B virus-related polyarteritis nodosa: two case reports and a review of the literature. (15045636)	Deeren D.H.... Blockmans D.	2004	GPT
8	Increased serum levels of interleukin-8 in polyarteritis nodosa and BehAset's disease. (15168145)	Freire A.d.e. .L.... Fernandes S.R.	2004	IL8
9	Unusual presentation of polyarteritis nodosa. (11327266)	Hall C.... Mongey A.B.	2001	APOH
10	Successful combination therapy of polyarteritis nodosa associated with a pre-core promoter mutant hepatitis B virus infection. (11434628)	Wartelle-Bladou C.... Zoulim F.	2001	IFNA1
11	Polyarteritis nodosa in patients with Familial Mediterranean Fever (FMF): a concomitant disease or a feature of FMF? (11182028)	Ozen S.... Akpolat T.	2001	MEFV
12	Polyarteritis nodosa mimicking prostatic cancer. (11036851)	GonzA!lez-La Riviere O.... Arce-Salinas C.A.	2000	KLK3
13	Manifestation of cutaneous polyarteritis nodosa durin g interferon therapy for chronic hepatitis C associated with primary biliary ci rrhosis. (11063225)	Dohmen K.... Ishibashi H.	2000	IFNA2
14	Dynamic pattern of endothelial cell adhesion molecule expression in muscle and perineural vessels from patients with classic polyarteritis nodosa. (9506571)	Coll-Vinent B.... Grau J.M.	1998	ICAM2
15	A case of polyneuropathy by microscopic polyarteritis nodosa (9989356)	Tanaka H.... Hirata K.	1998	CRP
16	A reversible posterior leukoencephalopathy syndrome in a patient with classical polyarteritis nodosa (9146079)	Arai M.... Wada M.	1997	MPO
17	Polyarteritis nodosa and the antiphospholipid syndrom e. (8853179)	Schoonjans R.... Elewaut A.	1996	APOH
18	Polyarteritis nodosa related to hepatitis B virus. A prospective study with long-term observation of 41 patients. (7565065)	Guillevin L.... TrAcpo C.	1995	IFNA2
19	Anti-neutrophil cytoplasmic antibody for proteinase 3 in a child with polyarteritis nodosa. (7754755)	Ito Y.... Kato H.	1995	PRTN3
20	Muscle involvement in polyarteritis nodosa: report of a patient presenting clinically as polymyositis and review of the literature. (7914924)	Fort J.G.... Abruzzo J.L.	1994	CHKB
21	Treatment of polyarteritis nodosa related to hepatitis B virus with interferon-alpha and plasma exchanges. (7912504)	Guillevin L.... TrAcpo C.	1994	IFNA2
22	Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa. (7907475)	Henshaw T.J.... Williams R.C.	1994	PRTN3
23	Anticardiolipin antibodies and polyarteritis nodosa. (7704011)	de la Fuente Fernandez R.... GraA+a Gil J.	1994	APOH
24	Treatment of polyarteritis nodosa related to hepatitis B virus with short term steroid therapy associated with antiviral agents and plasma exchanges. A prospective trial in 33 patients. (8097249)	Guillevin L.... Trepo C.	1993	IFNA2
25	Hyperrenin-hyperaldosterone-dependent malignant hypertension in polyarteritis nodosa. (7903825)	Thel M.C.... Allen N.B.	1993	REN
26	Distinct responses of interleukin-6 and other laborat ory parameters to treatment in a patient with polyarteritis nodosa--a case repo rt. (1350713)	Nakahama H.... Kubori S.	1992	IL6, CRP
27	Systemic necrotizing vasculitis with renal involvement accompanied by remarkable eosinophilia: a case with overlapping features of polyarteritis nodosa and allergic granulomatous angiitis. (1687066)	Sasaguri T.... Horie A.	1991	IGES
28	The American College of Rheumatology 1990 criteria fo r the classification of polyarteritis nodosa. (1975174)	Lightfoot R.W.... Lie J.T.	1990	GPT

Genes related to polyarteritis nodosa according to GeneCards:

(show all 20)

id	Symbol	Description	Score	GeneCards Section Context
1	IFNA2	interferon, alpha 2	11.1	Publications
2	MEFV	Mediterranean fever	11.0	Publications
3	PRTN3	proteinase 3	11.0	Publications
4	MPO	myeloperoxidase	11.0	Publications
5	LTF	lactotransferrin	11.0
6	ICAM2	intercellular adhesion molecule 2	11.0	Publications
7	IGES	immunoglobulin E concentration, serum	11.0	Publications
8	CPN1	carboxypeptidase N, polypeptide 1	11.0
9	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
10	DFFB	DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)	11.0
11	CHKB	choline kinase beta	11.0	Publications
12	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
13	REN	renin	11.0	Publications
14	CD40LG	CD40 ligand	11.0	Publications
15	IL8	interleukin 8	11.0	Publications
16	IFNA1	interferon, alpha 1	11.0	Publications
17	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
18	KLK3	kallikrein-related peptidase 3	11.0	Publications
19	CRP	C-reactive protein, pentraxin-related	11.0	Publications
20	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to polyarteritis nodosa according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	all-trans-Retinoic Acid Mediated Apoptosis36	9.9	IL6, IFNA2
2	Autoimmune thyroid disease20	9.5	IFNA2, IFNA1, CD40LG
3	Cytosolic DNA-sensing pathway20	9.3	IL6, IFNA1, IFNA2
4	Malaria20	9.2	CD40LG, IL6, IL8
5	Cytokine Network36	9.1	IL6, IL8, IFNA1, IFNA2
6	Toll-like receptor signaling pathway20	9.1	IFNA2, IFNA1, IL8, IL6
7	NOD-like receptor signaling pathway20	9.1	MEFV, IL6, IL8
8	Influenza A20	8.8	IFNA2, IFNA1, IL8, IL6
9	Cytokine-cytokine receptor interaction20	8.7	IFNA2, IFNA1, IL8, IL6, CD40LG
10	JAK-STAT Pathway36	8.5	IFNA2, IFNA1, IL8, IL6, FGF2

Compounds related to polyarteritis nodosa according to GeneDecks:

(show top 50)    (show all 179)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.3	APOH, LTF
2	polyethylene glycol32	10.2	MPO, IFNA2, CHKB
3	ivig32	10.0	CRP
4	intron a32	9.9	IFNA1, IFNA2
5	vitamin b1232	9.8	APOH, CD40LG, MPO, LTF
6	entecavir32	9.8	IFNA1, IFNA2, GPT
7	pge232	9.8	FGF2, LTF, REN
8	ascorbic acid32 18	10.8	CD40LG, LTF, IFNA2, CHKB
9	alpha tocopherol32	9.8	CHKB, IFNA2, KLK3
10	famciclovir32 9 9	11.6	GPT, IFNA1, IFNA2
11	rituximab32 34 9 9	12.5	CD40LG, CRP, PRTN3
12	clarithromycin32 9 9	11.5	LTF, GPT, CHKB, IL8
13	glycyrrhizin32	9.5	IFNA1, GPT, REN, LTF
14	erythromycin32 9 9	11.4	MPO, CD40LG, IFNA2, LTF, IL8
15	hydroxychloroquine32 9 9	11.4	CRP, CD40LG, APOH
16	ribavirin32 34 9 9	12.3	GPT, CD40LG, IFNA1, IFNA2, LTF
17	imiquimod32 42 9 9	12.2	IFNA1, IL8, IFNA2, IL6
18	endotoxin32	9.1	APOH, CHKB, LTF, MEFV, CRP
19	vitamin a32 9 18 9	12.1	IFNA2, GPT, LTF, CRP
20	pravastatin32 34 9 18 9	13.1	CRP, IL6, CHKB
21	hyaluronic acid32 18	10.0	PRTN3, LTF, KLK3, FGF2, GPT
22	il-1232	9.0	CD40LG, IL6, IL8, IFNA1
23	malondialdehyde32	8.9	GPT, MPO, CHKB, APOH, CRP
24	estrogen32	8.9	PRTN3, CHKB, APOH, KLK3, LTF
25	anaphylatoxin32	8.8	IL6, IL8, MPO, CPN1
26	pmma32	8.8	CRP, LTF, CD40LG, IL6
27	dextran sulfate32	8.7	IL6, APOH, CD40LG, MPO, KLK3, LTF
28	rosuvastatin32 34 9 9	11.7	GPT, CHKB, IL6, CRP
29	methacholine32 9 9	10.7	MPO, IGES, IL8, LTF, REN, CRP
30	etanercept32 9 9	10.7	IL8, IL6, CRP, IFNA2, APOH
31	8-isoprostane32	8.6	APOH, MPO, IL6, IL8, CRP
32	histamine32 18	9.6	IGES, MPO, IL6, IL8, LTF, IFNA2
33	azathioprine32 34 9 9	11.6	CHKB, APOH, CRP, IFNA2, PRTN3, LTF
34	latex32	8.5	LTF, CRP, IGES, APOH, CHKB
35	infliximab32 9 9	10.4	IFNA2, PRTN3, APOH, FGF2, IL6, CRP
36	thyroxine32 18	9.2	KLK3, IFNA2, GPT, FGF2, CD40LG, CHKB
37	thalidomide32 42 9 9	11.2	CD40LG, FGF2, KLK3, IFNA2, IFNA1, IL6
38	hydrocortisone32 9 9	10.2	IL8, FGF2, IL6, KLK3, REN, LTF
39	atorvastatin32 34 9 18 9	12.1	CRP, GPT, IL6, CD40LG, CHKB
40	aspirin32 34 18	10.0	KLK3, IGES, CRP, CD40LG, APOH, CHKB
41	fibrinogen32	8.0	CRP, CD40LG, CHKB, LTF, IL6, GPT
42	n acetylcysteine32	7.7	MPO, IL6, IL8, GPT, CRP, LTF
43	cyclosporin a32 42	8.5	LTF, IFNA1, IL6, IL8, GPT, IGES
44	creatinine32	7.5	IL6, APOH, CD40LG, MPO, CHKB, REN
45	prednisolone32 9 9	9.3	CRP, CHKB, MPO, FGF2, APOH, GPT
46	neopterin32	7.3	CD40LG, LTF, CRP, IFNA2, IL6, IFNA1
47	vegf32	7.2	LTF, CRP, APOH, FGF2, CD40LG, MPO
48	dexamethasone32 42 34 9 9	11.0	IL8, KLK3, IL6, CD40LG, LTF, CHKB
49	alanine32	6.9	IFNA2, IFNA1, LTF, GPT, CRP, PRTN3
50	lactate32	6.8	CD40LG, MPO, IL6, IL8, APOH, GPT

Cellular components related to polyarteritis nodosa according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	6.6	REN, CRP, IFNA2, APOH, IL8, IL6

Biological processes related to polyarteritis nodosa according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:006508	8.8	REN, LTF, KLK3, PRTN3, CPN1
2	negative regulation of lipid storage	GO:010888	8.8	CRP, IL6
3	inflammatory response	GO:006954	7.9	CD40LG, MEFV, IL6, IL8, IFNA2, CRP

Molecular functions related to polyarteritis nodosa according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	heparin binding	GO:008201	9.0	MPO, FGF2, APOH, LTF
2	cytokine activity	GO:005125	8.9	CD40LG, FGF2, IL6, IFNA2