PAN
MCID: PLY017
MIFTS: 69

Polyarteritis Nodosa (PAN) malady

Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Cardiovascular diseases categories

Summaries for Polyarteritis Nodosa

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Sources:
44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Polyarteritis nodosa is a serious blood vessel disease in which medium-sized arteries become swollen and damaged. it occurs when certain immune cells attack the affected arteries preventing vital oxygen and nourishment. signs and symptoms may include fever, fatigue, weakness, loss of appetite, weight loss, muscle and joint aches, and abdominal pain. the skin may show rashes, swelling, ulcers, and lumps. when nerve cells are involved numbness, pain, burning, and weakness may be present. polyarteritis nodosa can cause serious health complications including strokes, seizures, and kidney failure. treatment often includes steroids and other drugs to suppress the immune system. last updated: 1/16/2012

MalaCards: Polyarteritis Nodosa, also known as kĆ¼ssmaul-maier disease, is related to hepatitis and vasculitis, and has symptoms including mesenteric/intestinal infarction, arterial embolism/thrombosis and arterial stenosis/occlusion. An important gene associated with Polyarteritis Nodosa is CECR1 (cat eye syndrome chromosome region, candidate 1), and among its related pathways are Selenium Pathway and Immune response IL 23 signaling pathway. The compounds hydroxychloroquine and clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and brain, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Wikipedia:66 Polyarteritis nodosa, also known as panarteritis nodosa,periarteritis nodosa,), Kussmaul disease or... more...

Description from OMIM:48 615688

Aliases & Classifications for Polyarteritis Nodosa

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 28ICD9CM, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

50
polyarteritis nodosa:
Inheritance: Autosomal recessive,Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

polyarteritis nodosa 9 44 48 11 46 50 63
kĆ¼ssmaul-maier disease 50
periarteritis nodosa 50
pan 44


External Ids:

Disease Ontology9 DOID:9810
MeSH36 D010488
NCIt41 C26847
ICD9CM28 446.0
MESH via Orphanet37 D010488
ICD10 via Orphanet27 M30.0
SNOMED-CT via Orphanet60 155441006
UMLS via Orphanet64 C0031036
OMIM48 615688
ICD1026 M30.0

Related Diseases for Polyarteritis Nodosa

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Polyarteritis Nodosa via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 336)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.5GPT, IFNA1
2vasculitis31.2MEFV, PRTN3, MPO, APOH, LTF, CD40LG
3hepatitis b31.2GPT, LTF, IFNA1, IFNA2, HLA-DRB1
4churg-strauss syndrome31.2LTF, PRTN3, MPO
5familial mediterranean fever31.1MEFV, CRP
6crohn's disease30.9LTF, CRP
7mononeuritis multiplex30.9MPO, PRTN3
8myocardial infarction30.9REN, IGES, CHKB, CRP
9arthritis30.8IL6, IL8
10hepatitis c30.8IFNA2, PRTN3, GPT, HLA-DRB1, IFNA1, CD40LG
11ulcerative colitis30.7LTF, CRP, PRTN3
12retinal vasculitis30.7APOH
13thrombophlebitis30.7APOH
14acute myocardial infarction30.7IGES, CHKB, CRP, MEFV
15sinusitis30.6IGES, PRTN3
16retinal artery occlusion30.6APOH
17cholecystitis30.6GPT
18adult-onset still's disease30.6CRP
19lupus erythematosus30.6IFNA2, APOH
20glomerulonephritis30.5MPO, CD40LG, PRTN3
21nephritis30.5CD40LG, APOH, MPO, PRTN3
22autoimmune hepatitis30.5IFNA1, GPT, CD40LG, HLA-DRB1
23pneumonia30.5IL8, IL6, CRP, IGES, MPO
24vascular disease30.5PRTN3, CRP, APOH, FGF2
25cryoglobulinemic vasculitis30.4IFNA1, IFNA2, CD40LG
26leukemia30.4IFNA1, IFNA2, CD40LG, FGF2, IL6, ICAM2
27palindromic rheumatism30.4MEFV
28sneddon syndrome30.4APOH
29aortic aneurysm30.4CRP
30fibromuscular dysplasia30.4REN
31septic arthritis30.4CRP
32rapidly progressive glomerulonephritis30.4PRTN3, MPO
33endocarditis30.3PRTN3
34rhinitis30.3IGES, IL8
35hyperthyroidism30.3PRTN3, IGES, HLA-DRB1
36prostatitis30.3LTF, KLK3
37mixed connective tissue disease30.3PRTN3, APOH
38myeloma30.3FGF2, CD40LG, IL6, IFNA2, IFNA1
39polymyalgia rheumatica30.3CRP, HLA-DRB1
40meningitis30.2CRP, IL8, IL6
41synovitis30.2CRP, IL8, IL6
42inflammatory bowel disease30.2IL6, IL8, MPO
43myelofibrosis30.2IFNA1, FGF2, IFNA2
44eosinophilia30.2PRTN3, IGES, MPO, IL8, IFNA2
45primary biliary cirrhosis30.2HLA-DRB1, LTF, GPT, PRTN3, CD40LG
46pancreatitis30.2IL6, CRP, LTF, MPO, IGES
47cryoglobulinemia30.2IFNA1, IFNA2, CD40LG, APOH
48congenital heart disease30.2CRP, FGF2, MPO, IL6, CD40LG
49skin disease30.2HLA-DRB1, IFNA1, IL6, MPO
50acute pancreatitis30.1IL6, CRP, IL8, MPO, GPT

Graphical network of the top 20 diseases related to Polyarteritis Nodosa:



Diseases related to polyarteritis nodosa

Symptoms for Polyarteritis Nodosa

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Sources:
48OMIM, 50Orphanet
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Symptoms by clinical synopsis from OMIM:

615688

Clinical features from OMIM:

615688

Symptoms:

50 (show all 60)
  • mesenteric/intestinal infarction
  • arterial embolism/thrombosis
  • arterial stenosis/occlusion
  • extrapyramidal syndrome
  • vascularitis/vasculitides/arteritis
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • asthma/bronchospasm
  • arterial aneurism (excluding aorta)
  • cutis marmorata/marbled skin/livedo
  • edema of the legs/lower limbs
  • fever/chilling
  • hemobilia
  • acute ischemia of the lower limbs
  • acute ischemic syndrome
  • ureteral stenosis/narrowing
  • testes inflammation/orchitis
  • neuritis/polyneuritis/multineuritis
  • hyperleukocytosis/leukocytosis
  • intestinal perforation
  • acute arterial hypertension/hypertensive crisis
  • retinal detachment
  • retinal vascular anomalies/retinal telangiectasia
  • follicular/erythematous/edematous papules/milium
  • cutaneous rash
  • chronic skin infection/ulcerations/ulcers/cancrum
  • hepatitis/icterus/cholestasis
  • ascitis
  • cardiac rhythm disorder/arrhythmia
  • cardiomyopathy/hypertrophic/dilated
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • articular/joint pain/arthralgia
  • renal failure
  • renal disease/nephropathy
  • malabsorption/chronic diarrhea/steatorrhea
  • arthritis/synovitis/synovial proliferation
  • psychic/behavioural troubles
  • encephalitis
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • peripheral neuropathy
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • purpura/petichiae
  • pancreatitis
  • facial pain/cephalalgia/migraine
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • osteolysis/osteoclasia/bone destruction/erosions
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • myositis
  • angor pectoris/myocardial infarction
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • acute abdominal pain/colic
  • urticaria
  • autoimmunity/autoimmune reaction/autoantibodies
  • myalgia/muscular pain
  • gangrena/necrosis
  • heart/cardiac failure
  • pyramidal syndrome

Drugs & Therapeutics for Polyarteritis Nodosa

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Polyarteritis Nodosa

Drug clinical trials:

Search ClinicalTrials for Polyarteritis Nodosa

Search NIH Clinical Center for Polyarteritis Nodosa

Search CenterWatch for Polyarteritis Nodosa

Genetic Tests for Polyarteritis Nodosa

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Anatomical Context for Polyarteritis Nodosa

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34MalaCards
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MalaCards organs/tissues related to Polyarteritis Nodosa:

34
Skin, Kidney, Brain, Bone, Liver, Testes, Heart, Colon, Endothelial, Tongue, T cells, Breast, Testis, Lung, Prostate, B cells, Spleen, Myeloid

Animal Models for Polyarteritis Nodosa or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Polyarteritis Nodosa:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7MPO, CHKB, REN, MEFV, IL6, CRP
2MP:00053976.7FGF2, MPO, PRTN3, REN, ICAM2, MEFV
3MP:00053876.5MPO, PRTN3, REN, ICAM2, MEFV, IL8

Publications for Polyarteritis Nodosa

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Sources:
53PubMed
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Articles related to Polyarteritis Nodosa:

(show top 50)    (show all 597)
idTitleAuthorsYear
1
Polyarteritis nodosa in childhood: recognition of early dermatologic signs may prevent morbidity. (23937359)
2014
2
Necrosis of the tongue as first symptom of Polyarteritis Nodosa (PAN): unusual presentation of a rare disease in children. (21136262)
2013
3
Coronary Artery Bypass Grafting in a Patient with Polyarteritis Nodosa Presenting with Acute Myocardial Infarction and Multiple Coronary Aneurysms. (23995351)
2013
4
Macular arteritis: a pole of the spectrum of cutaneous polyarteritis nodosa? (22995948)
2013
5
Polyarteritis nodosa presenting as acute myocardial infarction in a young man: importance of invasive angiography. (23661639)
2013
6
Remission induced by infliximab in a childhood polyarteritis nodosa refractory to conventional immunosuppression and rituximab. (24388782)
2013
7
Comments on sudden death due to polyarteritis nodosa. (22052059)
2012
8
The usefulness of 3D-CT angiography in polyarteritis nodosa. (22687865)
2012
9
Cutaneous polyarteritis nodosa associated with HLA-B39-positive undifferentiated spondyloarthritis in a Japanese patient. (22270344)
2012
10
Polyarteritis nodosa and SjAPgren's syndrome: overlap syndrome. (20480165)
2012
11
Cutaneous polyarteritis nodosa induced by Mycobacterium tuberculosis. (22035185)
2012
12
A review of pediatric vasculitis with a focus on juvenile polyarteritis nodosa. (22845169)
2012
13
Cutaneous polyarteritis nodosa: complete clearance of the leg ulcer after the amputation of the contralateral leg. (21684840)
2011
14
Secondary retroperitoneal fibrosis due to polyarteritis nodosa evaluated by F-18 FDG PET/CT. (21975401)
2011
15
Classic polyarteritis nodosa presenting with rapidly progressive renal insufficiency. (20875386)
2010
16
Acute Myocardial Infarction due to Polyarteritis Nodosa in a Young Female Patient. (20421961)
2010
17
Fulminant polyarteritis nodosa associated with acute myeloid leukaemia resulted in bilateral lower leg amputation. (19553374)
2009
18
Hepatobiliary scintigraphy in vasculitis of the gallbladder as a manifestation of polyarteritis nodosa: a case report. (20062624)
2009
19
Improvement of cutaneous polyarteritis nodosa lesions with hyperbaric oxygen. (19702999)
2009
20
Cutaneous polyarteritis nodosa treated with intravenous immunoglobulins. (18031500)
2008
21
Polyarteritis nodosa: the great mimicker, mimicked. (18360328)
2008
22
SIR 2006 annual meeting film panel case: polyarteritis nodosa in upper extremity arteries. (17804766)
2007
23
A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. (16575492)
2007
24
A case of recurrent abdominal bleeding due to polyarteritis nodosa despite immunosuppressive therapy. (18092276)
2007
25
Lymphoplasmacytic lymphoma associated with polyradiculoneuritis and cryoglobulinemia mimicking polyarteritis nodosa. (17287105)
2007
26
Polyarteritis nodosa: successful diagnostic imaging utilizing pulsed and color Doppler ultrasonography and computed tomography angiography. (16222527)
2006
27
Hemobilia from ruptured hepatic artery aneurysm in polyarteritis nodosa. (16646571)
2006
28
Polyarteritis nodosa and cryoglobulinemic glomerulonephritis related to chronic hepatitis C. (16775442)
2006
29
Successful pregnancy complicated by microscopic polyarteritis nodosa. (15960155)
2005
30
Short-term corticosteroids then lamivudine and plasma exchanges to treat hepatitis B virus-related polyarteritis nodosa. (15188337)
2004
31
Successful response to infliximab in a patient with undifferentiated spondyloarthropathy coexisting with polyarteritis nodosa-like cutaneous vasculitis. (14740443)
2003
32
A patient with classical polyarteritis nodosa evolving into end stage renal failure. (14669863)
2003
33
Vasculitis: Wegener granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa, and Takayasu arteritis. (12418444)
2002
34
Duodenal necrosis as the presenting manifestation of polyarteritis nodosa. (12189461)
2002
35
Cutaneous polyarteritis nodosa. (11966708)
2002
36
Transient and partial effect of high-dose intravenous immunoglobulin in polyarteritis nodosa. (11586025)
2001
37
Treatment of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: where do we stand? (11263763)
2001
38
Hepatitis B-related polyarteritis nodosa complicated by pulmonary hemorrhage. (11348978)
2001
39
Spontaneous perirenal hematoma as the initial manifestation of polyarteritis nodosa and long-term follow-up without treatment. (10867546)
2000
40
Sensory ataxic dominant neuropathy associated with polyarteritis nodosa. (11030213)
2000
41
Childhood polyarteritis nodosa presenting as a relapsing movement disorder. (10685835)
2000
42
A case of cutaneous polyarteritis nodosa associated with ulcerative colitis. (10777260)
2000
43
Early lacunar strokes complicating polyarteritis nodosa: thrombotic microangiopathy. (10690981)
2000
44
Dynamic pattern of endothelial cell adhesion molecule expression in muscle and perineural vessels from patients with classic polyarteritis nodosa. (9506571)
1998
45
Disseminated intravascular coagulation complicating polyarteritis nodosa in alpha-1-antitrypsin deficiency. (9641193)
1998
46
Distinct responses of interleukin-6 and other laboratory parameters to treatment in a patient with polyarteritis nodosa--a case report. (1350713)
1992
47
Giant cell (temporal) arteritis following polyarteritis nodosa. (2567193)
1989
48
Cutaneous polyarteritis nodosa. Report of a case associated with Crohn's disease. (6132589)
1983
49
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14144116)
1964
50
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14045124)
1963

Variations for Polyarteritis Nodosa

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Polyarteritis Nodosa:

1
id Gene Name Type Significance SNP ID Assembly Location
1CECR1NM_001282227.1(CECR1): c.1232A> G (p.Tyr411Cys)single nucleotide variantPathogenic/card/polyarteritis_nodosaGRCh37Chr 22, 17662794: 17662794
2CECR1NM_001282227.1(CECR1): c.200C> A (p.Ala67Asp)single nucleotide variantPathogenic/card/polyarteritis_nodosaGRCh37Chr 22, 17688177: 17688177
3CECR1NM_001282227.1(CECR1): c.14G> C (p.Gly5Ala)single nucleotide variantPathogenicrs200930463GRCh37Chr 22, 17690428: 17690428
4CECR1NM_001282227.1(CECR1): c.210C> G (p.His70Gln)single nucleotide variantPathogenicGRCh37Chr 22, 17688167: 17688167
5CECR1NM_001282227.1(CECR1): c.380G> A (p.Arg127Gln)single nucleotide variantPathogenicrs77563738GRCh37Chr 22, 17687997: 17687997
6CECR1NM_001282227.1(CECR1): c.13G> A (p.Gly5Arg)single nucleotide variantPathogenicGRCh37Chr 22, 17690429: 17690429
7CECR1NM_001282227.1(CECR1): c.626C> T (p.Pro209Leu)single nucleotide variantPathogenicrs148936893GRCh37Chr 22, 17684454: 17684454
8CECR1NM_001282227.1(CECR1): c.14G> T (p.Gly5Val)single nucleotide variantPathogenicrs200930463GRCh37Chr 22, 17690428: 17690428
9CECR1NM_001282227.1(CECR1): c.665G> C (p.Trp222Ser)single nucleotide variantPathogenicGRCh37Chr 22, 17672663: 17672663

Expression for genes affiliated with Polyarteritis Nodosa

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyarteritis Nodosa

Search GEO for disease gene expression data for Polyarteritis Nodosa.

Pathways for genes affiliated with Polyarteritis Nodosa

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 54QIAGEN, 56Reactome, 31KEGG, 55R&D Systems
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Pathways related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway39
9.5MPO, IL6, CRP
2
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.5MPO, IL6, FGF2
3
Show member pathways
9.4MEFV, IL8, IL6
4
Show member pathways
9.4IL8, IFNA2, IFNA1
59.4IL8, IFNA2, IFNA1
69.3CD40LG, IL6, IL8
79.3IFNA1, IFNA2, IL6
8
Show member pathways
9.3IFNA1, IFNA2, IL6
99.3IL6, IFNA2, IFNA1
109.3HLA-DRB1, IL8, IL6
119.0CD40LG, ICAM2, HLA-DRB1
129.0MPO, ICAM2, IL6
139.0IFNA1, IFNA2, IL6, FGF2
14
Show member pathways
9.0HLA-DRB1, IFNA1, IFNA2, IL6
159.0HLA-DRB1, IFNA1, IFNA2, IL6
168.9IL8, IL6, KLK3, FGF2
178.9IL6, IL8, IFNA2, IFNA1
18
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.9IFNA1, IFNA2, IL8, IL6
19
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.9IFNA1, IFNA2, IL8, IL6
20
Show member pathways
8.7HLA-DRB1, IFNA1, IFNA2, IL6, CD40LG
21
Show member pathways
8.6IFNA1, IFNA2, IL8, IL6, CD40LG
22
Show member pathways
8.6FGF2, IL6, IL8, IFNA2, IFNA1
23
Show member pathways
8.5HLA-DRB1, IFNA1, IFNA2, IL8, IL6

Compounds for genes affiliated with Polyarteritis Nodosa

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 3BitterDB, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

(show top 50)    (show all 254)
idCompoundScoreTop Affiliating Genes
1hydroxychloroquine46 1210.8APOH, CRP, CD40LG, IFNA2
2clarithromycin46 1210.6IL8, LTF, GPT, CHKB
3entecavir469.6IFNA1, GPT, IFNA2
4malondialdehyde469.5GPT, CRP, CHKB, MPO, APOH
5glycyrrhizin46 3010.5LTF, GPT, REN, IFNA1
6erythromycin46 3 52 1212.5MPO, LTF, CD40LG, IFNA2, IL8
7pmma469.4IL6, LTF, CD40LG, CRP
8vitamin b12469.4LTF, CRP, MPO, APOH, GPT, CD40LG
9ribavirin46 52 1211.3LTF, CD40LG, GPT, IFNA2, IFNA1
10ivig469.3IL6, APOH, CRP, GPT, CD40LG
11alpha tocopherol469.3CRP, IFNA2, CHKB, APOH, GPT, KLK3
128-isoprostane469.3APOH, IL8, CRP, IL6, MPO
13etanercept46 52 1211.3IL6, IFNA2, CRP, IL8, APOH
14vitamin a46 25 1211.2CD40LG, IFNA2, CRP, LTF, GPT, FGF2
15polyethylene glycol469.1CHKB, CD40LG, CRP, IFNA2, MPO, IFNA1
16dextran sulfate469.1APOH, KLK3, MPO, CD40LG, LTF, IL6
17pravastatin46 52 30 25 1213.1CD40LG, CHKB, GPT, CRP, IL6
18cyclophosphamide46 52 1211.1MPO, IFNA1, IFNA2, CRP, LTF, APOH
19ascorbic acid46 2510.1CRP, CHKB, MPO, LTF, CD40LG, IFNA2
20il-12469.1CD40LG, IL8, IFNA1, IL6
21imiquimod46 62 30 1212.0IFNA2, IFNA1, IL8, IL6
22thyroxine46 2510.0KLK3, CD40LG, GPT, IFNA2, REN, CHKB
23azathioprine46 3 52 1211.9PRTN3, IFNA2, CHKB, APOH, CRP, LTF
24infliximab46 52 1210.9FGF2, CRP, IFNA2, PRTN3, APOH, IL6
25methacholine46 52 1210.9REN, LTF, CRP, IL8, MPO, IGES
26methotrexate52 46 1210.9APOH, HLA-DRB1, CHKB, CRP, GPT, IL6
27fibrinogen468.9CRP, GPT, APOH, CHKB, IL6, CD40LG
28hydrocortisone46 3 62 1211.8FGF2, IL6, IL8, LTF, KLK3, REN
29latex468.8IGES, LTF, CRP, CHKB, APOH
30thalidomide46 52 62 1211.7IFNA1, IFNA2, FGF2, CD40LG, KLK3, IL6
31aspirin46 52 30 2511.7APOH, KLK3, CRP, IGES, CD40LG, CHKB
32epinephrine46 25 1210.7CHKB, CD40LG, KLK3, REN, IL6, IFNA2
33endotoxin468.6APOH, CHKB, LTF, CRP, IL6, IL8
34superoxide46 259.6PRTN3, APOH, IFNA2, CHKB, LTF, IL8
35heparin46 30 25 1211.6IL8, FGF2, APOH, CD40LG, MPO, CHKB
36n acetylcysteine468.5LTF, IL6, IL8, MPO, GPT, CRP
37pge2468.5FGF2, REN, CHKB, IL8, MPO, LTF
38histamine46 30 2510.4LTF, CD40LG, IL6, IL8, IGES, IFNA2
39creatinine468.4REN, CHKB, MPO, IL6, APOH, GPT
40rituximab46 52 1210.4APOH, CD40LG, CRP, IL6, IFNA2, IFNA1
41prednisolone46 30 1210.2IFNA2, GPT, APOH, MPO, CHKB, IFNA1
42aspartate468.2IFNA2, GPT, CD40LG, LTF, CHKB, CRP
43hyaluronic acid46 259.1IL8, KLK3, CD40LG, LTF, IL6, GPT
44neopterin468.0CD40LG, GPT, IFNA1, IFNA2, IL8, IL6
45estrogen467.9KLK3, CHKB, APOH, FGF2, LTF, CD40LG
46dexamethasone46 52 30 1210.8IL8, IL6, FGF2, LTF, CD40LG, KLK3
47cyclosporin a46 30 629.6FGF2, LTF, IGES, GPT, CHKB, IFNA1
48lactate467.5IL8, CHKB, MPO, APOH, GPT, IGES
49alanine467.2HLA-DRB1, CD40LG, IFNA1, IL6, FGF2, CRP
50vegf466.9APOH, MPO, IFNA2, IL8, IL6, CRP

GO Terms for genes affiliated with Polyarteritis Nodosa

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17Gene Ontology
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Cellular components related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9REN, IFNA2, IL8, IL6, CRP, KLK3
2extracellular spaceGO:0056157.1APOH, MPO, REN, CECR1, IFNA2, IL8

Biological processes related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:0108889.6CRP, IL6
2response to lipopolysaccharideGO:0324969.5IL6, REN, MPO
3positive regulation of osteoblast differentiationGO:0456699.5IL6, LTF, FGF2
4agingGO:0075689.2CRP, IL6, MPO
5inflammatory responseGO:0069548.7CD40LG, CRP, IL6, IL8, IFNA2, MEFV

Molecular functions related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2FGF2, CD40LG, IL6, IFNA2
2heparin bindingGO:0082019.0FGF2, LTF, CECR1, MPO, APOH

Products for genes affiliated with Polyarteritis Nodosa

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polyarteritis Nodosa

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet