PAN
MCID: PLY017
MIFTS: 68

Polyarteritis Nodosa (PAN) malady

Neuronal diseases, Nephrological diseases, Bone diseases categories

Summaries for Polyarteritis Nodosa

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Polyarteritis nodosa is a serious blood vessel disease in which medium-sized arteries become swollen and damaged. it occurs when certain immune cells attack the affected arteries preventing vital oxygen and nourishment. signs and symptoms may include fever, fatigue, weakness, loss of appetite, weight loss, muscle and joint aches, and abdominal pain. the skin may show rashes, swelling, ulcers, and lumps. when nerve cells are involved numbness, pain, burning, and weakness may be present. polyarteritis nodosa can cause serious health complications including strokes, seizures, and kidney failure. treatment often includes steroids and other drugs to suppress the immune system. last updated: 1/16/2012

MalaCards: Polyarteritis Nodosa, also known as küssmaul-maier disease, is related to hepatitis and hepatitis b, and has symptoms including asthma/bronchospasm, cutis marmorata/marbled skin/livedo and arterial embolism/thrombosis. An important gene associated with Polyarteritis Nodosa is IFNA2 (interferon, alpha 2), and among its related pathways are Selenium Pathway and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds pge2 and erythromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and brain, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Wikipedia:63 Polyarteritis nodosa, also known as Panarteritis nodosa,Periarteritis nodosa,), Kussmaul disease or... more...

Description from OMIM:46 615688

Aliases & Classifications for Polyarteritis Nodosa

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

48
polyarteritis nodosa:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

polyarteritis nodosa 8 42 10 44 48 46 60
küssmaul-maier disease 48
periarteritis nodosa 48
pan 42


External Ids:

Disease Ontology8 DOID:9810
MeSH34 D010488
ICD9CM27 446.0
NCIt39 C26847
MESH via Orphanet35 D010488
ICD10 via Orphanet26 M30.0
SNOMED-CT via Orphanet57 155441006
UMLS via Orphanet61 C0031036
OMIM46 615688
ICD1025 M30.0

Related Diseases for Polyarteritis Nodosa

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Polyarteritis Nodosa via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 478)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.4GPT, IFNA1
2hepatitis b31.2GPT, IFNA1, IFNA2
3vasculitis31.2CD40LG, LTF, PRTN3, MPO, MEFV, CRP
4churg-strauss syndrome31.0MPO, PRTN3, LTF
5familial mediterranean fever30.9CRP, MEFV
6hepatitis c30.8IFNA2, IFNA1, LTF, CD40LG, GPT
7wegener's granulomatosis30.8MPO, PRTN3
8hypertension30.8REN, CRP
9myocardial infarction30.7REN, IGES, CHKB, CRP
10arthritis30.7CRP, IL6, IL8, FGF2, LTF, PRTN3
11mononeuritis multiplex30.7PRTN3, MPO
12crohn's disease30.7CRP, LTF
13kawasaki disease30.6GPT, CRP
14acute myocardial infarction30.6IGES, CHKB, MEFV, CRP
15retinal vasculitis30.5APOH
16ischemia30.5DFFB, MPO, CHKB, FGF2
17ulcerative colitis30.5ICAM2, CRP, MPO, PRTN3, CHKB, LTF
18autoimmune hepatitis30.4GPT, CD40LG, IFNA1
19vascular disease30.4APOH, CRP, PRTN3, FGF2
20pneumonia30.4IL6, IL8, IGES, MPO, CRP
21collagen disease30.4CRP
22leukemia30.4IFNA2, IFNA1, ICAM2, MPO, PRTN3, CD40LG
23peripheral vascular disease30.3MPO
24myositis30.3CHKB
25retinal artery occlusion30.3APOH
26cholecystitis30.3GPT
27psoriatic arthritis30.3CRP
28appendicitis30.3CRP
29lupus erythematosus30.3IFNA2, APOH
30multiple myeloma30.3IL6
31glomerulonephritis30.3CD40LG, PRTN3, MPO
32myopathy30.3CRP, CHKB, GPT
33adult-onset still's disease30.3IL6, CRP
34myeloma30.3IFNA2, IFNA1, CD40LG, FGF2, IL6
35aortic aneurysm30.1CRP
36rheumatic fever30.1CRP
37thyroiditis30.1IFNA1
38hyperthyroidism30.1IGES, PRTN3
39rhinitis30.1IL8, IGES
40skin disease30.1IFNA1, MPO, IL6
41acute leukemia30.1MPO, PRTN3
42meningitis30.1CRP, IL8, IL6
43synovitis30.1CRP, IL8, IL6
44pyoderma gangrenosum30.1MEFV
45dermatomyositis30.1CHKB
46endocarditis30.1PRTN3
47mixed connective tissue disease30.1PRTN3, APOH
48polymyalgia rheumatica30.1CRP
49polyneuropathy30.1CD40LG, IFNA2
50rapidly progressive glomerulonephritis30.1MPO, PRTN3

Graphical network of the top 20 diseases related to Polyarteritis Nodosa:



Diseases related to polyarteritis nodosa

Clinical Features for Polyarteritis Nodosa

About this section
Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

615688

Symptoms:

48 (show all 60)
  • asthma/bronchospasm
  • cutis marmorata/marbled skin/livedo
  • arterial embolism/thrombosis
  • arterial stenosis/occlusion
  • extrapyramidal syndrome
  • vascularitis/vasculitides/arteritis
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • acute arterial hypertension/hypertensive crisis
  • edema of the legs/lower limbs
  • intestinal perforation
  • fever/chilling
  • hemobilia
  • acute ischemia of the lower limbs
  • acute ischemic syndrome
  • ureteral stenosis/narrowing
  • testes inflammation/orchitis
  • neuritis/polyneuritis/multineuritis
  • hyperleukocytosis/leukocytosis
  • mesenteric/intestinal infarction
  • arterial aneurism (excluding aorta)
  • retinal detachment
  • retinal vascular anomalies/retinal telangiectasia
  • follicular/erythematous/edematous papules/milium
  • cutaneous rash
  • chronic skin infection/ulcerations/ulcers/cancrum
  • hepatitis/icterus/cholestasis
  • ascitis
  • cardiac rhythm disorder/arrhythmia
  • cardiomyopathy/hypertrophic/dilated
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • articular/joint pain/arthralgia
  • renal failure
  • renal disease/nephropathy
  • malabsorption/chronic diarrhea/steatorrhea
  • arthritis/synovitis/synovial proliferation
  • psychic/behavioural troubles
  • encephalitis
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • peripheral neuropathy
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • purpura/petichiae
  • pancreatitis
  • facial pain/cephalalgia/migraine
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • osteolysis/osteoclasia/bone destruction/erosions
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • myositis
  • angor pectoris/myocardial infarction
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • acute abdominal pain/colic
  • urticaria
  • autoimmunity/autoimmune reaction/autoantibodies
  • myalgia/muscular pain
  • gangrena/necrosis
  • heart/cardiac failure
  • pyramidal syndrome

Drugs & Therapeutics for Polyarteritis Nodosa

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Polyarteritis Nodosa

Drug clinical trials:

Search ClinicalTrials for Polyarteritis Nodosa

Search NIH Clinical Center for Polyarteritis Nodosa

Search CenterWatch for Polyarteritis Nodosa

Genetic Tests for Polyarteritis Nodosa

About this section

Anatomical Context for Polyarteritis Nodosa

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Polyarteritis Nodosa:

32
Skin, Kidney, Brain, Bone, Liver, Testes, Heart, Lung, Breast, Testis, T cells, Endothelial, Colon, Tongue, Prostate, Spleen, Myeloid, B cells

Animal Models for Polyarteritis Nodosa or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Polyarteritis Nodosa:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.9CRP, MEFV, CHKB, LTF, CD40LG, REN
2MP:00053977.1MPO, DFFB, MEFV, ICAM2, LTF, CD40LG
3MP:00053876.7CPN1, ICAM2, CRP, MEFV, DFFB, MPO

Publications for Polyarteritis Nodosa

About this section
Sources:
50PubMed
See all sources

Articles related to Polyarteritis Nodosa:

(show top 50)    (show all 607)
idTitleAuthorsYear
1
Polyarteritis nodosa in childhood: recognition of early dermatologic signs may prevent morbidity. (23937359)
2014
2
Macular arteritis: a pole of the spectrum of cutaneous polyarteritis nodosa? (22995948)
2013
3
Pathological features of classical polyarteritis nodosa: analysis of 19 autopsy cases. (23419691)
2013
4
Polyarteritis nodosa with multiple aneurysms and renal arteriovenous fistula successfully diagnosed by colour Doppler sonography. (20556452)
2013
5
Monoclonal gammopathy of undetermined significance and fatal polyarteritis nodosa. (23942636)
2013
6
Polyarteritis nodosa: a case presenting with renal mass. (22941495)
2012
7
Vasculitic multiplex mononeuritis: polyarteritis nodosa versus cryoglobulinemic vasculitis. (20401485)
2012
8
Polyarteritis nodosa with perforation of the cecum. (22706753)
2012
9
Secondary hyperaldosteronism in a patient with polyarteritis nodosa and renal artery aneurysms. (21549628)
2011
10
Polyarteritis nodosa presenting with bilateral testicular swelling and complicated by unilateral facial nerve palsy. (21687399)
2011
11
EULAR/PRINTO/PRES criteria for Henoch-SchAPnlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria. (20413568)
2010
12
Acute abdomen due to intestinal ischemia as an initial presentation of polyarteritis nodosa. (21332011)
2010
13
Cerebral miliary micro aneurysms in polyarteritis nodosa: report of two cases. (20644280)
2010
14
Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database. (20112401)
2010
15
Case reports: testicular pain as a manifestation of polyarteritis nodosa. (18651100)
2008
16
Clinical images: latency of polyarteritis nodosa until a critical occurrence. (18576357)
2008
17
Polyarteritis nodosa presenting with bilateral cavernous internal carotid artery aneurysms. (18227424)
2008
18
A paradigm of diagnostic criteria for polyarteritis nodosa: analysis of a series of 949 patients with vasculitides. (18438816)
2008
19
A case of recurrent abdominal bleeding due to polyarteritis nodosa despite immunosuppressive therapy. (18092276)
2007
20
The challenge of managing patients with polyarteritis nodosa. (17143093)
2007
21
Successful coil embolization of a ruptured hepatic aneurysm in a patient with polyarteritis nodosa accompanied by angioimmunoblastic T cell lymphoma. (17106619)
2007
22
Intravenous immunoglobulins in polyarteritis nodosa restricted to the limbs: case reports and review of the literature. (17428360)
2007
23
Successful treatment of childhood cutaneous polyarteritis nodosa with infliximab. (17374009)
2007
24
Polyarteritis nodosa: successful diagnostic imaging utilizing pulsed and color Doppler ultrasonography and computed tomography angiography. (16222527)
2006
25
Cryofibrinogenemia associated with polyarteritis nodosa. (16292471)
2006
26
Classic polyarteritis nodosa presenting rare clinical manifestations in a patient with hemophilia A. (16787873)
2006
27
Polyarteritis nodosa. (16845849)
2006
28
High incidence of polyarteritis nodosa in the brains of culled sows. (15699610)
2005
29
Acute cholecystitis at initial presentation of polyarteritis nodosa. (15789142)
2005
30
Spontaneous renal laceration as the presenting feature of polyarteritis nodosa in a patient with familial Mediterranean fever after hepatitis A infection. (15765217)
2005
31
Short-term corticosteroids then lamivudine and plasma exchanges to treat hepatitis B virus-related polyarteritis nodosa. (15188337)
2004
32
Hemobilia as presenting manifestation of polyarteritis nodosa. (15176541)
2004
33
Visceral leishmaniasis in a patient treated for polyarteritis nodosa. (14740438)
2003
34
Polyarteritis nodosa in a cynomolgus macaque (Macaca fascicularis). (12949416)
2003
35
Parvovirus B19 infection associated with myelosuppression and cutaneous polyarteritis nodosa. (12364654)
2002
36
Polyarteritis nodosa presenting as a pyrexia of unknown origin. (12496328)
2002
37
Localized polyarteritis nodosa of the gallbladder. (12102490)
2002
38
Localized polyarteritis nodosa with periostitis. (11764232)
2001
39
Autologous stem cell transplantation for paediatric-onset polyarteritis nodosa: changes in autoimmune phenotype in the context of reduced diversity of the T- and B-cell repertoires, and evidence for reversion from the CD45RO(+) to RA(+) phenotype. (11709615)
2001
40
Polyarteritis nodosa developing after discoid lupus erythematosus. (11791651)
2001
41
Spontaneous perirenal hematoma as the initial manifestation of polyarteritis nodosa and long-term follow-up without treatment. (10867546)
2000
42
Bilateral vocal fold paralysis caused by polyarteritis nodosa. (10609489)
1999
43
Estrogen-sensitive cutaneous polyarteritis nodosa: response to tamoxifen. (9777776)
1998
44
Cutaneous polyarteritis nodosa. (8669946)
1996
45
Cutaneous polyarteritis nodosa. Reports of two cases in children and review of the literature. (7912919)
1994
46
Hyperrenin-hyperaldosterone-dependent malignant hypertension in polyarteritis nodosa. (7903825)
1993
47
Necrotizing mesenteric vasculitis after longstanding cutaneous polyarteritis nodosa. (1357171)
1992
48
Prognosis of cutaneous polyarteritis nodosa. (21234050)
1990
49
Cutaneous polyarteritis nodosa and Crohn's disease. (4146816)
1972
50
ANAPHYLACTOID PURPURA, POLYARTERITIS NODOSA AND PURPURA FULMINANS. (14145022)
1963

Genetic Variations for Polyarteritis Nodosa

About this section

Expression for genes affiliated with Polyarteritis Nodosa

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Polyarteritis Nodosa

Search GEO for disease gene expression data for Polyarteritis Nodosa.

Pathways for genes affiliated with Polyarteritis Nodosa

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 51QIAGEN, 52R&D Systems
See all sources

Compounds for genes affiliated with Polyarteritis Nodosa

About this section
Sources:
44Novoseek, 49PharmGKB, 2BitterDB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
See all sources

Compounds related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

(show top 50)    (show all 196)
idCompoundScoreTop Affiliating Genes
1pge24410.6REN
2erythromycin44 49 2 1113.4IFNA2, LTF
3ribavirin44 49 1112.4IFNA2, CD40LG
4endotoxin4410.1CHKB, APOH, MEFV, LTF
5vitamin a44 11 2412.0FGF2, LTF, IFNA2
6alpha tocopherol449.9APOH, KLK3, IFNA2, CHKB
7hydroxychloroquine44 1110.9CD40LG, APOH, IFNA2, CRP
8ivig449.8GPT, CD40LG, CRP, APOH
9clarithromycin44 1110.7CHKB, LTF, IL8, GPT
10anaphylatoxin449.7IL8, CPN1, MPO
11entecavir449.7GPT, IFNA2, IFNA1
12pmma449.6LTF, CD40LG, IL6, CRP
13malondialdehyde449.6APOH, CRP, MPO, GPT, CHKB
14superoxide44 2410.6LTF, IFNA2, APOH, CHKB
15cyclophosphamide44 49 1111.5APOH, IFNA1, IFNA2, CRP
16vitamin b12449.5MPO, CRP, GPT, CD40LG, LTF, APOH
17famciclovir44 1110.5GPT, IFNA1, IFNA2
18etanercept44 49 1111.5CRP, IFNA2, IL8, IL6, APOH
198-isoprostane449.5IL6, MPO, CRP, APOH, IL8
20glycyrrhizin44 2810.5LTF, REN, GPT, IFNA1
21creatinine449.5CHKB, GPT, REN, CRP, APOH, LTF
22hydrocortisone44 2 59 1112.4KLK3, IL8, REN, FGF2, LTF
23intron a449.4IFNA2, IFNA1, REN
24dextran sulfate449.3IL6, MPO, CD40LG, LTF, KLK3, APOH
25pravastatin44 49 28 11 2413.3CHKB, CD40LG, IL6, GPT, CRP
26estrogen449.3APOH, CHKB, LTF, PRTN3, KLK3
27epinephrine44 11 2411.3REN, CD40LG, IFNA2, CHKB
28ascorbic acid44 2410.2CHKB, CD40LG, FGF2, IFNA2, CRP, MPO
29il-12449.2IFNA1, CD40LG, IL8, IL6
30azathioprine44 49 2 1112.2CRP, IFNA2, GPT, PRTN3, CHKB, LTF
31imiquimod44 28 59 1112.2IL6, IFNA2, IL8, IFNA1
32infliximab44 49 1111.1PRTN3, IFNA2, CRP, APOH, FGF2, IL6
33polyethylene glycol449.1MPO, CD40LG, CHKB, CRP, IFNA1, IFNA2
34thyroxine44 2410.1KLK3, FGF2, CD40LG, CHKB, IFNA2, GPT
35cyclosporin a44 28 5911.1FGF2, CHKB, GPT, IFNA1, LTF, CD40LG
36fibrinogen449.0CD40LG, GPT, APOH, CRP, CHKB, LTF
37latex448.9LTF, IGES, CHKB, CRP, APOH
38thalidomide44 49 59 1111.8CD40LG, FGF2, IFNA2, KLK3, IFNA1, IL6
39methacholine44 119.8LTF, REN, IL8, IGES, CRP, MPO
40n acetylcysteine448.8CRP, GPT, IL6, IL8, CD40LG, LTF
41rituximab44 49 1110.6CD40LG, IL6, IFNA2, IFNA1, APOH, CRP
42aspirin44 49 28 2411.5CRP, CD40LG, APOH, KLK3, IGES, CHKB
43dexamethasone44 49 28 1111.5KLK3, IFNA1, IL6, FGF2, CD40LG, LTF
44hyaluronic acid44 249.5GPT, IL8, FGF2, CD40LG, LTF, PRTN3
45histamine44 28 2410.4IL6, IFNA2, MPO, IGES, LTF, CD40LG
46prednisolone44 28 1110.3FGF2, IFNA1, IFNA2, APOH, CRP, GPT
47neopterin448.2LTF, IFNA2, IFNA1, CRP, GPT, IL6
48alanine447.8PRTN3, FGF2, CRP, CD40LG, LTF, IFNA2
49lactate447.6IGES, IL8, MPO, CHKB, CRP, APOH
50vegf447.1LTF, CRP, KLK3, IFNA2, IFNA1, APOH

GO Terms for genes affiliated with Polyarteritis Nodosa

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2IFNA2, CRP, LTF, REN, FGF2, IL8
2extracellular spaceGO:0056157.5CPN1, IFNA2, APOH, CRP, MPO, CD40LG

Biological processes related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:0108889.5CRP, IL6
2proteolysisGO:0065089.0CPN1, REN, LTF, PRTN3, KLK3
3inflammatory responseGO:0069548.8IL6, IL8, CD40LG, MEFV, CRP, IFNA2

Molecular functions related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.4IL6, FGF2, CD40LG, IFNA2
2heparin bindingGO:0082019.3FGF2, LTF, MPO, APOH

Products for genes affiliated with Polyarteritis Nodosa

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polyarteritis Nodosa

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet