PAN
MCID: PLY017
MIFTS: 62

Polyarteritis Nodosa (PAN) malady

Neuronal, Nephrological, Bone categories

Summaries for Polyarteritis Nodosa

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Polyarteritis nodosa is a serious blood vessel disease in which medium-sized arteries become swollen and damaged. it occurs when certain immune cells attack the affected arteries preventing vital oxygen and nourishment. signs and symptoms may include fever, fatigue, weakness, loss of appetite, weight loss, muscle and joint aches, and abdominal pain. the skin may show rashes, swelling, ulcers, and lumps. when nerve cells are involved numbness, pain, burning, and weakness may be present. polyarteritis nodosa can cause serious health complications including strokes, seizures, and kidney failure. treatment often includes steroids and other drugs to suppress the immune system. last updated: 1/16/2012

MalaCards: Polyarteritis Nodosa, also known as küssmaul-maier disease, is related to hepatitis c and vasculitis, and has symptoms including pyramidal syndrome, seizures/epilepsy/absences/spasms/status epilepticus and hemiplegia/diplegia/hemiparesia/limb palsy. An important gene associated with Polyarteritis Nodosa is IFNA2 (interferon, alpha 2), and among its related pathways are Selenium Pathway and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds pge2 and erythromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Wikipedia:64 Polyarteritis nodosa, also known as Panarteritis nodosa,Periarteritis nodosa,), Kussmaul disease or... more...

Aliases & Classifications for Polyarteritis Nodosa

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Nephrological, Bone


Characteristics (Orphanet epidemiological data):

49
polyarteritis nodosa:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

polyarteritis nodosa 8 43 10 45 49 61
küssmaul-maier disease 49
periarteritis nodosa 49
pan 43


External Ids:

Disease Ontology8 DOID:9810
MeSH35 D010488
ICD9CM27 446.0
NCIt40 C26847
MESH via Orphanet36 D010488
ICD10 via Orphanet26 M30.0
SNOMED-CT via Orphanet58 155441006
UMLS via Orphanet62 C0031036
ICD1025 M30.0

Related Diseases for Polyarteritis Nodosa

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Polyarteritis Nodosa via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 459)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c31.3IFNA1, GPT, LTF, CD40LG, IFNA2
2vasculitis31.3CRP, MEFV, MPO, PRTN3, LTF, CD40LG
3churg-strauss syndrome31.0MPO, PRTN3, LTF
4familial mediterranean fever31.0CRP, MEFV
5wegener's granulomatosis30.9PRTN3, MPO
6hepatitis e30.8CD40LG, GPT
7arthritis30.8LTF, FGF2, IL8, IL6, PRTN3, CRP
8mononeuritis multiplex30.7PRTN3, MPO
9acute myocardial infarction30.7CRP, MEFV, IGES, CHKB
10retinal vasculitis30.6APOH
11hepatitis b30.6IFNA1, GPT, IFNA2
12ulcerative colitis30.6IL8, IL6, CRP, MPO, PRTN3, ICAM2
13polymyositis30.5CHKB
14kawasaki disease30.5GPT, CRP
15hepatitis d30.5GPT, IFNA2, IFNA1
16autoimmune hepatitis30.5GPT, CD40LG, IFNA1
17vascular disease30.5PRTN3, CRP, APOH, FGF2
18peripheral vascular disease30.4MPO
19psoriatic arthritis30.4CRP
20appendicitis30.4CRP
21nephritis30.4CD40LG, MPO, PRTN3, APOH
22cryoglobulinemic vasculitis30.4IFNA1, IFNA2, CD40LG
23adult-onset still's disease30.4IL6, CRP
24aortic aneurysm30.2CRP
25rheumatic fever30.2CRP
26amyloidosis, secondary30.2CRP, MEFV
27synovitis30.2IL8, IL6, CRP
28acute leukemia30.2MPO, PRTN3
29pyoderma gangrenosum30.2MEFV
30mixed connective tissue disease30.2APOH, PRTN3
31polymyalgia rheumatica30.2CRP
32rapidly progressive glomerulonephritis30.2PRTN3, MPO
33amyloidosis30.2CRP, MEFV
34rheumatoid vasculitis30.1LTF
35primary biliary cirrhosis30.1PRTN3, GPT, CD40LG, LTF
36cryoglobulinemia30.1IFNA2, IFNA1, APOH, CD40LG
37tuberculosis30.1CRP, IGES
38acute pancreatitis30.1CRP, IL8, IL6, GPT, MPO
39asthma30.1PRTN3, MPO, IL8, IGES, CHKB
40systemic lupus erythematosus30.1PRTN3, MPO, IL6, CD40LG, IFNA1, APOH
41uveitis30.0IFNA2
42proliferative diabetic retinopathy29.9FGF2, IL8
43colorectal cancer29.9IFNA1, LTF, IFNA2
44hemorrhagic fever29.7CD40LG
45subacute sclerosing panencephalitis29.7IFNA1
46hypercholesterolemia29.7CRP, GPT
47adenocarcinoma29.7DFFB, KLK3
48mycosis fungoides29.7IFNA2, IFNA1
49reactive arthritis29.7LTF, PRTN3, CRP
50sjogren's syndrome29.7APOH, PRTN3, LTF, CD40LG

Graphical network of the top 20 diseases related to Polyarteritis Nodosa:



Diseases related to polyarteritis nodosa

Clinical Features for Polyarteritis Nodosa

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 60)
  • pyramidal syndrome
  • seizures/epilepsy/absences/spasms/status epilepticus
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • encephalitis
  • psychic/behavioural troubles
  • arthritis/synovitis/synovial proliferation
  • malabsorption/chronic diarrhea/steatorrhea
  • renal disease/nephropathy
  • renal failure
  • fever/chilling
  • articular/joint pain/arthralgia
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • cardiomyopathy/hypertrophic/dilated
  • cardiac rhythm disorder/arrhythmia
  • ascitis
  • hepatitis/icterus/cholestasis
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cutaneous rash
  • follicular/erythematous/edematous papules/milium
  • peripheral neuropathy
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • heart/cardiac failure
  • gangrena/necrosis
  • myalgia/muscular pain
  • autoimmunity/autoimmune reaction/autoantibodies
  • urticaria
  • acute abdominal pain/colic
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • angor pectoris/myocardial infarction
  • myositis
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • osteolysis/osteoclasia/bone destruction/erosions
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • facial pain/cephalalgia/migraine
  • pancreatitis
  • purpura/petichiae
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • retinal vascular anomalies/retinal telangiectasia
  • retinal detachment
  • arterial aneurism (excluding aorta)
  • asthma/bronchospasm
  • acute arterial hypertension/hypertensive crisis
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • vascularitis/vasculitides/arteritis
  • extrapyramidal syndrome
  • arterial stenosis/occlusion
  • arterial embolism/thrombosis
  • cutis marmorata/marbled skin/livedo
  • edema of the legs/lower limbs
  • intestinal perforation
  • mesenteric/intestinal infarction
  • hyperleukocytosis/leukocytosis
  • neuritis/polyneuritis/multineuritis
  • testes inflammation/orchitis
  • ureteral stenosis/narrowing
  • acute ischemic syndrome
  • acute ischemia of the lower limbs
  • hemobilia

Drugs & Therapeutics for Polyarteritis Nodosa

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Polyarteritis Nodosa

Drug clinical trials:

Search ClinicalTrials for Polyarteritis Nodosa

Search NIH Clinical Center for Polyarteritis Nodosa

Search CenterWatch for Polyarteritis Nodosa

Genetic Tests for Polyarteritis Nodosa

Anatomical Context for Polyarteritis Nodosa

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Polyarteritis Nodosa:

33
Skin, Liver, Tongue, Brain, Kidney, Lung, Spleen, Small intestine, Colon, Breast, Prostate, Testis, Myeloid, T cells, B cells, Endothelial, Testis germ

Animal Models for Polyarteritis Nodosa or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Polyarteritis Nodosa:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.9CRP, MEFV, CHKB, LTF, CD40LG, REN
2MP:00053977.1MPO, DFFB, MEFV, ICAM2, LTF, CD40LG
3MP:00053876.7CPN1, ICAM2, CRP, MEFV, DFFB, MPO

Publications for Polyarteritis Nodosa

Sources:
51PubMed
See all sources

Articles related to Polyarteritis Nodosa:

(show top 50)    (show all 607)
idTitleAuthorsYear
1
Significance of Two Skin Biopsy Performances with Consecutive Deeper Sections in the Differential Diagnosis Between Cutaneous Polyarteritis Nodosa and Livedo Vasculopathy. (23756560)
2014
2
Cardiac arrest in a patient with polyarteritis nodosa. (24334581)
2013
3
Cutaneous polyarteritis nodosa presenting with digital gangrene and breast ulcer. (24131568)
2013
4
Drug-eluting stent patency at 6 months in the pedal artery of a patient with polyarteritis nodosa: a case report. (23707099)
2013
5
Bilateral femoral periostitis revealing polyarteritis nodosa. (24272984)
2013
6
Ruptured intracranial aneurysms in pediatric polyarteritis nodosa: case report. (23269053)
2012
7
Polyarteritis nodosa with central nervous system involvement mimicking relapsing-remitting multiple sclerosis. (23124610)
2012
8
Hepatitis C virus-associated polyarteritis nodosa. (20981809)
2011
9
Polyarteritis nodosa associated with essential mixed cryglobulinemia revealed by subarachnoid hemorrhage. (22129506)
2011
10
Correlation of livedo racemosa, cutaneous inflammatory plaques, and antiphospholipid antibodies in patients with cutaneous polyarteritis nodosa. (21358438)
2011
11
Childhood cutaneous polyarteritis nodosa: an unusual presentation. (19499224)
2010
12
Cutaneous polyarteritis nodosa in childhood: a case report and review of the literature. (22046510)
2010
13
An old autopsy report sheds light on a "new" disease: infantile polyarteritis nodosa and kawasaki disease. (20054530)
2010
14
Hepatobiliary scintigraphy in vasculitis of the gallbladder as a manifestation of polyarteritis nodosa: a case report. (20062624)
2009
15
Cutaneous polyarteritis nodosa in a child following hepatitis B vaccination. (19467971)
2009
16
HLA-DR in Brazilian patients with polyarteritis nodosa (PAN) and microscopic polyangiitis (MPA). (19597292)
2009
17
Ruptured aneurysm of a renal artery in a patient with polyarteritis nodosa. (18661718)
2008
18
Perinuclear antineutrophilic cytoplasmic antibody-positive polyarteritis nodosa secondary to minocycline treatment for acne vulgaris. (18489046)
2008
19
Protracted febrile myalgia mimicking polyarteritis nodosa. (18636021)
2008
20
A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. (16575492)
2007
21
Bilateral testicular infarction and orchiectomy as a complication of polyarteritis nodosa. (18231620)
2007
22
Isolated necrotizing arteritis (localized polyarteritis nodosa): examination of the histological process and disease entity based on the histological classification of stage and histological differences from polyarteritis nodosa. (17317542)
2007
23
Polyarteritis nodosa and cryoglobulinemic glomerulonephritis related to chronic hepatitis C. (16775442)
2006
24
A new treatment for polyarteritis nodosa. (16421155)
2006
25
Myasthenia gravis with cutaneous polyarteritis nodosa. (16487094)
2006
26
Additional case of minocycline-induced cutaneous polyarteritis nodosa: comment on the article by Culver et al. (17013846)
2006
27
Successful pregnancy complicated by microscopic polyarteritis nodosa. (15960155)
2005
28
Polyarteritis nodosa presenting with a leg mass. (16431412)
2005
29
Acute pachymeningitis mimicking subdural hematoma in a patient with polyarteritis nodosa. (15999274)
2005
30
Giant gastroduodenal artery pseudoaneurysm due to polyarteritis nodosa as a cause of obstructive jaundice: imaging findings and coil embolization results. (16132389)
2005
31
Increased serum levels of interleukin-8 in polyarteritis nodosa and BehAset's disease. (15168145)
2004
32
Polyarteritis nodosa with renal artery stenosis. (14767092)
2004
33
Polyarteritis nodosa and cutaneous polyarteritis nodosa. (14673260)
2003
34
Historical perspective of vasculitis: polyarteritis nodosa and microscopic polyangiitis. (11798985)
2002
35
Successful treatment of acute liver failure due to polyarteritis nodosa. (12361830)
2002
36
Hepatitis B-related polyarteritis nodosa complicated by pulmonary hemorrhage. (11348978)
2001
37
Life-threatening complications of hepatitis B virus-related polyarteritis nodosa developing despite interferon-alpha2b therapy: successful treatment with a combination of interferon, lamivudine, plasma exchanges and steroids. (11529642)
2001
38
Polyarteritis nodosa complicated by thrombotic thrombocytopenic purpura. (11345082)
2001
39
Perinuclear antineutrophilic cytoplasmic antibody-positive cutaneous polyarteritis nodosa associated with minocycline therapy for acne vulgaris. (11174376)
2001
40
Penetrating colon ulcer of polyarteritis nodosa: report of a case. (11496085)
2001
41
Polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome. Clinical aspects and treatment. (8592743)
1995
42
Muscle involvement in polyarteritis nodosa: report of a patient presenting clinically as polymyositis and review of the literature. (7914924)
1994
43
Intestinal perforation as an initial presentation of polyarteritis nodosa in an 8-year-old boy. (8097768)
1993
44
Benign cutaneous polyarteritis nodosa. Relationship to systemic polyarteritis nodosa and to hepatitis B infection. (1681787)
1991
45
Atypical angiomatosis in polyarteritis nodosa. (2878681)
1986
46
Cutaneous polyarteritis nodosa associated with rapidly progressive arthritis. (6144311)
1984
47
Polyarteritis nodosa associated with sarcocystosis in a lamb. (39432)
1979
48
Polyarteritis Nodosa "mimicking" eosinophilic gastroenteritis. (237305)
1975
49
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14045124)
1963
50
The pulmonary aspects of polyarteritis (periarteritis) nodosa. (13148425)
1954

Genetic Variations for Polyarteritis Nodosa

Expression for genes affiliated with Polyarteritis Nodosa

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Polyarteritis Nodosa

Search GEO for disease gene expression data for Polyarteritis Nodosa.

Pathways for genes affiliated with Polyarteritis Nodosa

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 52QIAGEN, 53R&D Systems
See all sources

Compounds for genes affiliated with Polyarteritis Nodosa

Sources:
45Novoseek, 50PharmGKB, 2BitterDB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

(show top 50)    (show all 196)
idCompoundScoreTop Affiliating Genes
1pge24510.6REN
2erythromycin45 50 2 1113.4IFNA2, LTF
3ribavirin45 50 1112.4IFNA2, CD40LG
4endotoxin4510.1CHKB, APOH, MEFV, LTF
5vitamin a45 11 2412.0FGF2, LTF, IFNA2
6alpha tocopherol459.9APOH, KLK3, IFNA2, CHKB
7hydroxychloroquine45 1110.9CD40LG, APOH, IFNA2, CRP
8ivig459.8GPT, CD40LG, CRP, APOH
9clarithromycin45 1110.7CHKB, LTF, IL8, GPT
10anaphylatoxin459.7IL8, CPN1, MPO
11entecavir459.7GPT, IFNA2, IFNA1
12pmma459.6LTF, CD40LG, IL6, CRP
13malondialdehyde459.6APOH, CRP, MPO, GPT, CHKB
14superoxide45 2410.6LTF, IFNA2, APOH, CHKB
15cyclophosphamide45 50 1111.5APOH, IFNA1, IFNA2, CRP
16vitamin b12459.5MPO, CRP, GPT, CD40LG, LTF, APOH
17famciclovir45 1110.5GPT, IFNA1, IFNA2
18etanercept45 50 1111.5CRP, IFNA2, IL8, IL6, APOH
198-isoprostane459.5IL6, MPO, CRP, APOH, IL8
20glycyrrhizin45 2910.5LTF, REN, GPT, IFNA1
21creatinine459.5CHKB, GPT, REN, CRP, APOH, LTF
22hydrocortisone45 2 60 1112.4KLK3, IL8, REN, FGF2, LTF
23intron a459.4IFNA2, IFNA1, REN
24dextran sulfate459.3IL6, MPO, CD40LG, LTF, KLK3, APOH
25pravastatin45 50 29 11 2413.3CHKB, CD40LG, IL6, GPT, CRP
26estrogen459.3APOH, CHKB, LTF, PRTN3, KLK3
27epinephrine45 11 2411.3REN, CD40LG, IFNA2, CHKB
28ascorbic acid45 2410.2CHKB, CD40LG, FGF2, IFNA2, CRP, MPO
29il-12459.2IFNA1, CD40LG, IL8, IL6
30azathioprine45 50 2 1112.2CRP, IFNA2, GPT, PRTN3, CHKB, LTF
31imiquimod45 29 60 1112.2IL6, IFNA2, IL8, IFNA1
32infliximab45 50 1111.1PRTN3, IFNA2, CRP, APOH, FGF2, IL6
33polyethylene glycol459.1MPO, CD40LG, CHKB, CRP, IFNA1, IFNA2
34thyroxine45 2410.1KLK3, FGF2, CD40LG, CHKB, IFNA2, GPT
35cyclosporin a45 29 6011.1FGF2, CHKB, GPT, IFNA1, LTF, CD40LG
36fibrinogen459.0CD40LG, GPT, APOH, CRP, CHKB, LTF
37latex458.9LTF, IGES, CHKB, CRP, APOH
38thalidomide45 50 60 1111.8CD40LG, FGF2, IFNA2, KLK3, IFNA1, IL6
39methacholine45 119.8LTF, REN, IL8, IGES, CRP, MPO
40n acetylcysteine458.8CRP, GPT, IL6, IL8, CD40LG, LTF
41rituximab45 50 1110.6CD40LG, IL6, IFNA2, IFNA1, APOH, CRP
42aspirin45 50 29 2411.5CRP, CD40LG, APOH, KLK3, IGES, CHKB
43dexamethasone45 50 29 1111.5KLK3, IFNA1, IL6, FGF2, CD40LG, LTF
44hyaluronic acid45 249.5GPT, IL8, FGF2, CD40LG, LTF, PRTN3
45histamine45 29 2410.4IL6, IFNA2, MPO, IGES, LTF, CD40LG
46prednisolone45 29 1110.3FGF2, IFNA1, IFNA2, APOH, CRP, GPT
47neopterin458.2LTF, IFNA2, IFNA1, CRP, GPT, IL6
48alanine457.8PRTN3, FGF2, CRP, CD40LG, LTF, IFNA2
49lactate457.6IGES, IL8, MPO, CHKB, CRP, APOH
50vegf457.1LTF, CRP, KLK3, IFNA2, IFNA1, APOH

GO Terms for genes affiliated with Polyarteritis Nodosa

Sources:
16Gene Ontology
See all sources

Cellular components related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2KLK3, IFNA2, CRP, LTF, REN, FGF2
2extracellular spaceGO:0056157.5IFNA2, APOH, CRP, MPO, CD40LG, REN

Biological processes related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:0108889.5CRP, IL6
2proteolysisGO:0065089.0CPN1, REN, LTF, PRTN3, KLK3
3inflammatory responseGO:0069548.8IL6, IL8, CD40LG, MEFV, CRP, IFNA2

Molecular functions related to Polyarteritis Nodosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.4IL6, FGF2, CD40LG, IFNA2
2heparin bindingGO:0082019.3FGF2, LTF, MPO, APOH

Products for genes affiliated with Polyarteritis Nodosa

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polyarteritis Nodosa

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet