MCID: PLY065
MIFTS: 40

Polyarticular Onset Juvenile Idiopathic Arthritis malady

Rare diseases, Eye diseases, Respiratory diseases, Bone diseases categories

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Sources:
42NIH Rare Diseases, 48Orphanet, 61UMLS, 26ICD10 via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Polyarticular Onset Juvenile Idiopathic Arthritis:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 42
Polyarticular Juvenile Rheumatoid Arthritis 42 61
Juvenile Polyarthritis Rheumatoid Factor Positive 42
Juvenile Polyarthritis Rheumatoid Factor Negative 42
Juvenile Rheumatoid Factor-Negative Polyarthritis 48
 
Juvenile Rheumatoid Factor-Positive Polyarthritis 48
Polyarthritis Without Rheumatoid Factor 48
Polyarthritis with Rheumatoid Factor 48
Juvenile Chronic Polyarthritis 61


Classifications:



Characteristics (Orphanet epidemiological data):

48
juvenile rheumatoid factor-negative polyarthritis:
Inheritance: Multigenic/multifactorial; Age of death: normal life expectancy
juvenile rheumatoid factor-positive polyarthritis:
Age of onset: Childhood; Age of death: normal life expectancy


External Ids:

Orphanet48 85408, 85435
ICD10 via Orphanet26 M08.3, M08.0
ICD1025 M13.0

Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards based summary: Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to juvenile rheumatoid arthritis and arthritis, and has symptoms including abnormality of the teeth, arthritis and limitation of joint mobility. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is CD247 (CD247 molecule), and among its related pathways are IL2-mediated signaling events and Inflammatory Response Pathway. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include bone and eye, and related mouse phenotypes are digestive/alimentary and cellular.

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

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Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile rheumatoid arthritis31.9IL2RB, IL2RA
2arthritis30.8IL2RB, PTPN22
3rheumatoid arthritis30.6TYK2, PTPN22, FAS, STAT4, IL2RA, IL2RB
4systemic lupus erythematosus29.5CD247, TYK2, PTPN22, FAS, STAT4, IL2RA
5juvenile rheumatoid factor-negative polyarthritis without anti-nuclear antibodies10.7
6juvenile rheumatoid factor-negative polyarthritis with anti-nuclear antibodies10.7
7uveitis10.5IL2RA
8aortic valve insufficiency10.4
9lupus erythematosus10.4
10endotheliitis10.4
11posterior uveitis10.3IL2RB, IL2RA
12thyroiditis10.3PTPN22
13tropical spastic paraparesis10.3IL2RA, IL2RB
14extrinsic allergic alveolitis10.3IL2RB, IL2RA
15acute graft versus host disease10.3IL2RB, IL2RA
16severe combined immunodeficiency, x-linked10.3IL2RB, IL2RA
17adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency10.3IL2RA, IL2RB
18common variable immunodeficiency10.3IL2RB, IL2RA
19hcl-v10.3IL2RA, IL2RB
20pulmonary sarcoidosis10.3IL2RA, IL2RB
21vogt-koyanagi-harada disease10.3IL2RA, FAS
22peripheral t-cell lymphoma10.3IL2RA, IL2RB
23pulmonary tuberculosis10.3IL2RA, CD247
24autoimmune lymphoproliferative syndrome10.2IL2RA, FAS
25mycosis fungoides10.2IL2RB, IL2RA
26anaplastic large cell lymphoma10.2IL2RA, IL2RB
27splenomegaly10.2IL2RA, FAS
28diphtheria10.2IL2RB, IL2RA
29hodgkin lymphoma10.2IL2RA, IL2RB, CD247
30sezary's disease10.2STAT4, IL2RA, IL2RB
31hepatitis10.1FAS, IL2RB
32cutaneous t cell lymphoma10.1FAS, IL2RA, IL2RB
33graft-versus-host disease, protection against10.1IL2RB, IL2RA, FAS
34severe combined immunodeficiency10.1TYK2, IL2RA, IL2RB
35chronic lymphocytic leukemia10.1IL2RB, IL2RA, FAS
36t-cell leukemia10.1IL2RB, IL2RA, FAS
37lymphoma, non-hodgkin10.1FAS, IL2RA, IL2RB
38systemic scleroderma10.0PTPN22, IL2RA, IL2RB
39sjogren's syndrome10.0FAS, IL2RA
40connective tissue disease10.0PTPN22, IL2RA
41hypersensitivity reaction type ii disease10.0PTPN22, IL2RA
42eosinophilia10.0IL2RB, IL2RA
43hashimoto thyroiditis10.0PTPN22, FAS, IL2RA
44graves' disease10.0PTPN22, FAS, IL2RA
45kidney cancer10.0FAS, IL2RA, IL2RB, CD247
46viral infectious disease10.0FAS, IL2RA, IL2RB, CD247
47multiple sclerosis, disease progression, modifier of9.9PTPN22, STAT4, IL2RA, IL2RB
48lymphopenia9.8PTPN22, FAS, IL2RA, IL2RB
49ipex syndrome9.8FAS, STAT4, IL2RA, IL2RB, CD247
50leukemia9.7TYK2, FAS, IL2RA, IL2RB, CD247

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to polyarticular onset juvenile idiopathic arthritis

Symptoms for Polyarticular Onset Juvenile Idiopathic Arthritis

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Symptoms:

 48 (show all 9)
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • joint/articular deformation
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • micrognathia/retrognathia/micrognathism/retrognathism

HPO human phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

(show all 9)
id Description Frequency HPO Source Accession
1 abnormality of the teeth hallmark (90%) HP:0000164
2 arthritis hallmark (90%) HP:0001369
3 limitation of joint mobility hallmark (90%) HP:0001376
4 joint swelling hallmark (90%) HP:0001386
5 arthralgia hallmark (90%) HP:0002829
6 autoimmunity hallmark (90%) HP:0002960
7 abnormality of the teeth typical (50%) HP:0000164
8 micrognathia typical (50%) HP:0000347
9 autoimmunity occasional (7.5%) HP:0002960

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

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Drug clinical trials:

Search ClinicalTrials for Polyarticular Onset Juvenile Idiopathic Arthritis

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

31
Bone, Eye

Animal Models for Polyarticular Onset Juvenile Idiopathic Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053817.8PTPN2, PTPN22, FAS, IL2RA
2MP:00053847.7CD247, FAS, PTPN22, PTPN2, TYK2
3MP:00053787.2TYK2, PTPN2, PTPN22, FAS, IL2RA, IL2RB
4MP:00053976.7CD247, TYK2, PTPN2, PTPN22, FAS, STAT4
5MP:00053876.6TYK2, PTPN2, PTPN22, FAS, STAT4, IL2RA
6MP:00107686.5TYK2, PTPN2, PTPN22, FAS, STAT4, IL2RA

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? (18802807)
2008

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL-2 Signaling pathway36
9.8IL2RB, IL2RA
29.8IL2RB, IL2RA
3
Show member pathways
Immune response IL 3 activation and signaling pathway59
9.8IL2RB, IL2RA
4
Show member pathways
IL2 signaling events mediated by STAT536
9.8IL2RA, IL2RB
59.7IL2RA, STAT4
69.5STAT4, TYK2
7
Show member pathways
9.5TYK2, STAT4
8
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway59
9.5STAT4, TYK2
9
Show member pathways
IL27-mediated signaling events36
9.5TYK2, STAT4
109.4IL2RA, CD247, STAT4
11
Show member pathways
9.3STAT4, IL2RA, IL2RB
12
Show member pathways
9.2FAS, IL2RA, IL2RB
13
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
9.2IL2RB, IL2RA, TYK2
14
Show member pathways
9.2IL2RB, TYK2, IL2RA
159.2IL2RB, IL2RA, TYK2
16
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.2STAT4, FAS, CD247
179.2STAT4, TYK2, IL2RA
18
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.0IL2RB, IL2RA, CD247, STAT4
19
Show member pathways
8.8IL2RB, TYK2, STAT4, IL2RA
20
Show member pathways
Type III interferon signaling36
8.8IL2RB, TYK2, STAT4, IL2RA
21
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.8CD247, PTPN2, FAS
22
Show member pathways
8.7IL2RB, IL2RA, FAS, TYK2
23
Show member pathways
8.7IL2RA, FAS, TYK2, IL2RB
248.6IL2RB, IL2RA, FAS, PTPN22
25
Show member pathways
Immune response IL 12 induced IFN gamma production59
8.5CD247, IL2RB, IL2RA, STAT4, TYK2
26
Show member pathways
Immune response IL 22 signaling pathway59
G protein signaling N RAS regulation pathway59
8.5CD247, IL2RA, STAT4, TYK2, IL2RB
27
Show member pathways
8.4TYK2, IL2RA, PTPN2, IL2RB
28
Show member pathways
8.3IL2RB, IL2RA, PTPN22, PTPN2

Compounds for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Compounds related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 49)
idCompoundScoreTop Affiliating Genes
1lentinan4410.2IL2RB, IL2RA
2mycophenolate4410.2IL2RA, IL2RB
3thymoglobulin4410.2IL2RA, IL2RB
4denileukin diftitox44 50 1112.2IL2RA, IL2RB
5delta9-tetrahydrocannabinol4410.2IL2RA, IL2RB
6daclizumab44 1111.2IL2RB, IL2RA
7basiliximab44 1111.2IL2RA, IL2RB
8alemtuzumab44 1111.2IL2RB, IL2RA
9levamisole44 1111.1IL2RA, IL2RB
10cuprophan4410.1IL2RA, IL2RB
11polysulfone4410.1IL2RA, IL2RB
12mycophenolic acid44 50 1112.1IL2RB, IL2RA
13phorbol 12,13-dibutyrate4410.1IL2RB, IL2RA
14fitc4410.1IL2RB, IL2RA
15con a4410.1IL2RB, IL2RA
162,5-oligoadenylate4410.0IL2RB, IL2RA
17il 104410.0IL2RA, IL2RB
18mycophenolate mofetil44 50 1112.0IL2RA, IL2RB
19erythromycin44 1 50 1113.0IL2RB, IL2RA
20lactose44 1111.0IL2RB, IL2RA
21pentoxifylline44 1110.9IL2RB, IL2RA
222-chlorodeoxyadenosine449.9FAS, IL2RA
23neopterin449.9IL2RA, IL2RB
24okt3449.7IL2RA, IL2RB, FAS
25infliximab44 50 1111.7FAS, IL2RA, IL2RB
26ivig449.7IL2RB, FAS, IL2RA
27prednisolone44 28 1111.7IL2RA, IL2RB, FAS
28ionomycin449.6IL2RB, FAS, IL2RA
29aspirin44 50 28 2412.6FAS, IL2RA, IL2RB
30rantes449.6FAS, IL2RA, IL2RB
31n acetylcysteine449.6IL2RB, FAS, IL2RA
32anisomycin44 1110.6IL2RA, FAS
33polysaccharide449.6FAS, IL2RB, IL2RA
34rapamycin449.5IL2RA, IL2RB, FAS
35genistein44 28 60 1 24 1114.5FAS, IL2RB, IL2RA
36gp 130449.5TYK2, FAS, IL2RA
37cyclosporin a44 28 6011.5IL2RA, IL2RB, FAS
38melatonin44 28 60 24 1113.5IL2RA, IL2RB
39thymidine44 2410.4FAS, IL2RB, IL2RA
40cisplatin44 50 60 1112.3IL2RB, IL2RA, FAS
41creatinine449.2IL2RA, IL2RB, FAS
42dexamethasone44 50 28 1112.2FAS, STAT4, IL2RB, IL2RA
43ifn-alpha449.2FAS, IL2RA, IL2RB, TYK2
44aspartate449.1FAS, IL2RB, IL2RA
45phosphotyrosine448.8TYK2, STAT4, IL2RB, PTPN2
46phosphatidylinositol448.4IL2RB, IL2RA, STAT4, CD247, TYK2, FAS
47serine448.2PTPN2, IL2RB, STAT4, FAS, TYK2
48arginine447.9PTPN22, CD247, IL2RB, IL2RA, FAS, PTPN2
49tyrosine447.0CD247, TYK2, PTPN2, PTPN22, FAS, STAT4

GO Terms for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.2IL2RB, IL2RA, FAS

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1activation-induced cell death of T cellsGO:00069249.6IL2RA, FAS
2negative regulation of inflammatory responseGO:00507289.3IL2RA, PTPN2
3negative regulation of T cell receptor signaling pathwayGO:00508609.0PTPN2, PTPN22
4T cell differentiationGO:00302178.9PTPN22, PTPN2
5peptidyl-tyrosine dephosphorylationGO:00353358.7PTPN22, PTPN2
6cytokine-mediated signaling pathwayGO:00192218.5IL2RB, STAT4, PTPN2, TYK2

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:00049119.8IL2RB, IL2RA
2interleukin-2 bindingGO:00199769.7IL2RB, IL2RA
3kinase bindingGO:00199009.0FAS, PTPN22
4protein tyrosine phosphatase activityGO:00047259.0PTPN22, PTPN2

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet