MCID: PLY065
MIFTS: 45

Polyarticular Onset Juvenile Idiopathic Arthritis malady

Rare diseases, Eye diseases, Respiratory diseases, Bone diseases categories
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Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

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33MalaCards
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MalaCards: Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to juvenile rheumatoid arthritis and rheumatoid arthritis, and has symptoms including biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp, biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp and autoimmunity/autoimmune reaction/autoantibodies. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is CD247 (CD247 molecule), and among its related pathways are IL2-mediated signaling events and IL2 signaling events mediated by PI3K. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include bone and eye, and related mouse phenotypes are digestive/alimentary and cellular.

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

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43NIH Rare Diseases, 62UMLS, 49Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

49
juvenile rheumatoid factor-negative polyarthritis:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000; Age of death: Normal
juvenile rheumatoid factor-positive polyarthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

polyarticular onset juvenile idiopathic arthritis 43
polyarticular juvenile rheumatoid arthritis 43 62
juvenile polyarthritis rheumatoid factor negative 43
juvenile polyarthritis rheumatoid factor positive 43
juvenile rheumatoid factor-negative polyarthritis 49
juvenile rheumatoid factor-positive polyarthritis 49
polyarthritis without rheumatoid factor 49
polyarthritis with rheumatoid factor 49


External Ids:

ICD10 via Orphanet26 M08.3, M08.0
ICD1025 M13.0

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

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17GeneCards, 18GeneDecks
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Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile rheumatoid arthritis31.6IL2RA, IL2RB
2rheumatoid arthritis31.2IL2RA, IL2RB, TYK2, STAT4, PTPN22, FAS
3arthritis30.7PTPN22, IL2RB
4systemic lupus erythematosus30.3IL2RB, CD247, IL2RA, TYK2, PTPN22, FAS
5juvenile rheumatoid factor-negative polyarthritis without anti-nuclear antibodies10.5
6juvenile rheumatoid factor-negative polyarthritis with anti-nuclear antibodies10.5
7aortic valve insufficiency10.4
8lupus erythematosus10.4
9mannose-binding lectin deficiency10.4
10endotheliitis10.4
11uveitis10.1IL2RA
12posterior uveitis10.1IL2RB, IL2RA
13thyroiditis10.1PTPN22
14tropical spastic paraparesis10.1IL2RA, IL2RB
15immunodeficiency, common variable, 710.1IL2RB, IL2RA
16extrinsic allergic alveolitis10.1IL2RA, IL2RB
17acute graft versus host disease10.1IL2RB, IL2RA
18gamma chain deficiency10.1IL2RB, IL2RA
19congenital stationary night blindness, type 1f10.1IL2RA, IL2RB
20common variable immune deficiency10.1IL2RB, IL2RA
21hairy cell leukemia10.1IL2RA, IL2RB
22pulmonary sarcoidosis10.1IL2RB, IL2RA
23vogt-koyanagi-harada disease10.1FAS, IL2RA
24peripheral t-cell lymphoma10.1IL2RA, IL2RB
25pulmonary tuberculosis10.1IL2RA, CD247
26autoimmune lymphoproliferative syndrome10.1FAS, IL2RA
27mycosis fungoides10.1IL2RB, IL2RA
28anaplastic large cell lymphoma10.0IL2RB, IL2RA
29splenomegaly10.0IL2RA, FAS
30diphtheria10.0IL2RA, IL2RB
31hodgkin's lymphoma10.0CD247, IL2RA, IL2RB
32sezary's disease10.0IL2RA, IL2RB, STAT4
33hepatitis10.0IL2RB, FAS
34cutaneous t cell lymphoma10.0IL2RA, FAS, IL2RB
35graft versus host disease10.0IL2RA, IL2RB, FAS
36severe combined immunodeficiency10.0IL2RA, IL2RB, TYK2
37b-cell chronic lymphocytic leukemia10.0FAS, IL2RA, IL2RB
38t-cell leukemia10.0IL2RA, IL2RB, FAS
39non-hodgkin lymphoma10.0IL2RB, FAS, IL2RA
40systemic scleroderma10.0IL2RA, PTPN22, IL2RB
41sjogren's syndrome10.0IL2RA, FAS
42connective tissue disease10.0PTPN22, IL2RA
43hypersensitivity reaction type ii disease10.0PTPN22, IL2RA
44eosinophilia10.0IL2RB, IL2RA
45autoimmune thyroiditis10.0PTPN22, FAS, IL2RA
46graves' disease10.0PTPN22, FAS, IL2RA
47kidney cancer10.0IL2RA, FAS, IL2RB, CD247
48viral infectious disease10.0IL2RA, IL2RB, CD247, FAS
49multiple sclerosis10.0PTPN22, IL2RA, IL2RB, STAT4
50lymphopenia10.0PTPN22, FAS, IL2RB, IL2RA

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to polyarticular onset juvenile idiopathic arthritis

Symptoms for Polyarticular Onset Juvenile Idiopathic Arthritis

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49Orphanet
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Symptoms:

49 (show all 9)
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • autoimmunity/autoimmune reaction/autoantibodies
  • micrognathia/retrognathia/micrognathism/retrognathism
  • hydrarthrosis/articular/joint effusion
  • articular/joint pain/arthralgia
  • restricted joint mobility/joint stiffness/ankylosis
  • arthritis/synovitis/synovial proliferation
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • joint/articular deformation

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Polyarticular Onset Juvenile Idiopathic Arthritis

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

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33MalaCards
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MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

33
Bone, Eye

Animal Models for Polyarticular Onset Juvenile Idiopathic Arthritis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053817.8PTPN2, PTPN22, FAS, IL2RA
2MP:00053847.7CD247, FAS, PTPN22, PTPN2, TYK2
3MP:00053787.2TYK2, PTPN2, PTPN22, FAS, IL2RA, IL2RB
4MP:00053976.7CD247, TYK2, PTPN2, PTPN22, FAS, STAT4
5MP:00053876.6TYK2, PTPN2, PTPN22, FAS, STAT4, IL2RA
6MP:00107686.5TYK2, PTPN2, PTPN22, FAS, STAT4, IL2RA

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

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52PubMed
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Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? (18802807)
2008

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 5Cell Signaling Technology, 54R&D Systems, 53QIAGEN, 55Reactome, 30KEGG
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Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL-2 Signaling pathway38
9.8IL2RB, IL2RA
2
Show member pathways
IL2 signaling events mediated by STAT538
9.8IL2RB, IL2RA
39.8IL2RB, IL2RA
4
Show member pathways
Immune response IL 3 activation and signaling pathway60
9.8IL2RB, IL2RA
59.7STAT4, IL2RA
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.5STAT4, TYK2
79.5TYK2, STAT4
8
Show member pathways
9.5TYK2, STAT4
9
Show member pathways
IL27-mediated signaling events38
9.5STAT4, TYK2
109.4CD247, IL2RA, STAT4
11
Show member pathways
9.3IL2RB, IL2RA, STAT4
12
Show member pathways
9.2FAS, IL2RA, IL2RB
13
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.2IL2RB, IL2RA, TYK2
14
Show member pathways
9.2IL2RB, IL2RA, TYK2
159.2TYK2, IL2RA, IL2RB
16
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.2FAS, STAT4, CD247
179.2IL2RA, STAT4, TYK2
18
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.0STAT4, IL2RA, IL2RB, CD247
19
Show member pathways
8.8TYK2, STAT4, IL2RA, IL2RB
20
Show member pathways
Type III interferon signaling38
8.8TYK2, STAT4, IL2RA, IL2RB
21
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
8.8CD247, FAS, PTPN2
22
Show member pathways
8.7IL2RB, IL2RA, FAS, TYK2
23
Show member pathways
8.7TYK2, FAS, IL2RA, IL2RB
248.6PTPN22, FAS, IL2RA, IL2RB
25
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.5TYK2, STAT4, IL2RA, IL2RB, CD247
26
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.5CD247, IL2RB, IL2RA, STAT4, TYK2
27
Show member pathways
8.4TYK2, PTPN2, IL2RA, IL2RB
28
Show member pathways
8.3PTPN2, PTPN22, IL2RA, IL2RB

Compounds for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 3BitterDB, 29IUPHAR, 24HMDB, 61Tocris Bioscience
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Compounds related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1lentinan4510.2IL2RB, IL2RA
2mycophenolate4510.2IL2RB, IL2RA
3thymoglobulin4510.2IL2RA, IL2RB
4denileukin diftitox45 51 1112.2IL2RB, IL2RA
5delta9-tetrahydrocannabinol4510.2IL2RB, IL2RA
6daclizumab45 1111.2IL2RB, IL2RA
7basiliximab45 1111.2IL2RA, IL2RB
8alemtuzumab45 1111.2IL2RB, IL2RA
9levamisole45 1111.1IL2RB, IL2RA
10cuprophan4510.1IL2RB, IL2RA
11polysulfone4510.1IL2RB, IL2RA
12mycophenolic acid45 51 1112.1IL2RA, IL2RB
13phorbol 12,13-dibutyrate4510.1IL2RB, IL2RA
14fitc4510.1IL2RA, IL2RB
15con a4510.1IL2RA, IL2RB
162,5-oligoadenylate4510.0IL2RA, IL2RB
17mycophenolate mofetil45 51 1112.0IL2RB, IL2RA
18il 104510.0IL2RB, IL2RA
19erythromycin45 3 51 1113.0IL2RB, IL2RA
20lactose45 1111.0IL2RB, IL2RA
21pentoxifylline45 1110.9IL2RB, IL2RA
222-chlorodeoxyadenosine459.9FAS, IL2RA
23neopterin459.9IL2RB, IL2RA
24okt3459.7FAS, IL2RA, IL2RB
25infliximab45 51 1111.7IL2RB, IL2RA, FAS
26ivig459.7IL2RB, IL2RA, FAS
27prednisolone45 29 1111.7FAS, IL2RA, IL2RB
28ionomycin459.6IL2RB, IL2RA, FAS
29aspirin45 51 29 2412.6IL2RB, IL2RA, FAS
30rantes459.6FAS, IL2RA, IL2RB
31n acetylcysteine459.6IL2RB, IL2RA, FAS
32anisomycin45 1110.6IL2RA, FAS
33polysaccharide459.6IL2RB, IL2RA, FAS
34rapamycin459.5IL2RB, IL2RA, FAS
35genistein45 29 61 3 24 1114.5IL2RB, IL2RA, FAS
36gp 130459.5IL2RA, FAS, TYK2
37cyclosporin a45 29 6111.5FAS, IL2RA, IL2RB
38melatonin45 29 61 24 1113.5IL2RB, IL2RA
39thymidine45 2410.4FAS, IL2RA, IL2RB
40cisplatin45 51 61 1112.3IL2RB, IL2RA, FAS
41creatinine459.2FAS, IL2RA, IL2RB
42dexamethasone45 51 29 1112.2IL2RB, IL2RA, STAT4, FAS
43ifn-alpha459.2TYK2, FAS, IL2RA, IL2RB
44aspartate459.1IL2RB, IL2RA, FAS
45phosphotyrosine458.8TYK2, PTPN2, STAT4, IL2RB
46phosphatidylinositol458.4TYK2, FAS, STAT4, IL2RA, IL2RB, CD247
47serine458.2TYK2, PTPN2, FAS, STAT4, IL2RB
48arginine457.9PTPN2, PTPN22, FAS, IL2RA, IL2RB, CD247
49tyrosine457.0CD247, TYK2, PTPN2, PTPN22, FAS, STAT4

GO Terms for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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16Gene Ontology
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Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2IL2RB, IL2RA, FAS

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation-induced cell death of T cellsGO:0069249.6IL2RA, FAS
2negative regulation of inflammatory responseGO:0507289.3IL2RA, PTPN2
3negative regulation of T cell receptor signaling pathwayGO:0508609.0PTPN2, PTPN22
4T cell differentiationGO:0302178.9PTPN22, PTPN2
5peptidyl-tyrosine dephosphorylationGO:0353358.7PTPN22, PTPN2
6cytokine-mediated signaling pathwayGO:0192218.5IL2RB, STAT4, PTPN2, TYK2

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:0049119.8IL2RB, IL2RA
2interleukin-2 bindingGO:0199769.7IL2RB, IL2RA
3kinase bindingGO:0199009.0FAS, PTPN22
4protein tyrosine phosphatase activityGO:0047259.0PTPN22, PTPN2

Products for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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  • Antibodies
  • Proteins
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Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet