MCID: PLY065
MIFTS: 48

Polyarticular Onset Juvenile Idiopathic Arthritis malady

Eye diseases, Respiratory diseases, Bone diseases categories

Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to rheumatoid arthritis and arthritis, and has symptoms including autoimmunity/autoimmune reaction/autoantibodies, abnormal dentition/dental position/implantation/unerupted/dental ankylosis and micrognathia/retrognathia/micrognathism/retrognathism. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include bone and eye, and related mouse phenotypes are limbs/digits/tail and skeleton.

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

About this section
Sources:
42NIH Rare Diseases, 60UMLS, 48Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
juvenile rheumatoid factor-negative polyarthritis:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000; Age of death: Normal
juvenile rheumatoid factor-positive polyarthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

polyarticular onset juvenile idiopathic arthritis 42
polyarticular juvenile rheumatoid arthritis 42 60
juvenile polyarthritis rheumatoid factor negative 42
juvenile polyarthritis rheumatoid factor positive 42
juvenile rheumatoid factor-negative polyarthritis 48
juvenile rheumatoid factor-positive polyarthritis 48
polyarthritis without rheumatoid factor 48
polyarthritis with rheumatoid factor 48


External Ids:

ICD10 via Orphanet26 M08.3, M08.0
ICD1025 M13.0

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis31.3FAS, TNFRSF11B, STAT4, TYK2, IL2RA, IL2RB
2arthritis30.5TNFRSF11A, TNFRSF11B, IL2RB, PTPN22, TNFSF11
3vascular disease30.5TNFRSF11B, TNFSF11, TNFRSF11A
4systemic lupus erythematosus30.4IL2RB, IL2RA, PTPN22, CD247, FAS, STAT4
5juvenile rheumatoid arthritis10.9
6juvenile rheumatoid factor-negative polyarthritis without anti-nuclear antibodies10.5
7juvenile rheumatoid factor-negative polyarthritis with anti-nuclear antibodies10.5
8aortic valve insufficiency10.3
9lupus erythematosus10.3
10root resorption10.0TNFRSF11B
11paget's disease of bone10.0TNFRSF11A
12crohn's disease10.0PTPN2
13periodontitis10.0TNFRSF11B
14uveitis10.0IL2RA
15lupus nephritis10.0IL2RA
16cystic fibrosis10.0TNFRSF11B
17thyroiditis10.0PTPN22
18hemophagocytic lymphohistiocytosis10.0IL2RA
19celiac disease10.0PTPN22
20acute myocardial infarction10.0TNFSF11
21hyperthyroidism10.0PTPN22
22uremia10.0TNFRSF11B
23giant cell tumor10.0TNFSF11
24hepatitis10.0IL2RB
25obesity10.0PTPN2
26diabetes mellitus10.0PTPN22
27tuberculosis10.0IL2RA
28arthropathy10.0TNFRSF11B, TNFSF11
29synovitis10.0TNFSF11, TNFRSF11B
30multiple myeloma10.0TNFRSF11B, TNFSF11
31osteosclerosis10.0TNFRSF11B, TNFSF11
32periapical granuloma10.0TNFSF11, IL2RA
33hyperparathyroidism10.0TNFSF11, TNFRSF11B
34cholesteatoma10.0TNFRSF11B, TNFSF11
35viral hepatitis10.0FAS
36psoriasis10.0PTPN22, IL2RA
37aortic valve stenosis10.0TNFRSF11B, TNFSF11
38common variable immune deficiency10.0IL2RB, IL2RA
39vitiligo10.0PTPN22
40posterior uveitis10.0IL2RA, IL2RB
41sarcoidosis10.0IL2RB, IL2RA
42beta thalassemia10.0TNFRSF11B, TNFSF11
43polyostotic osteolytic dysplasia, hereditary expansile10.0TNFRSF11A, TNFSF11, TNFRSF11B
44paget disease, juvenile10.0TNFRSF11B, TNFSF11, TNFRSF11A
45mycosis fungoides10.0IL2RB, IL2RA
46hypersensitivity reaction type ii disease10.0IL2RA, PTPN22
47osteoarthritis10.0TNFRSF11B, TNFRSF11A, TNFSF11
48hypercalcemia10.0TNFSF11, TNFRSF11A, TNFRSF11B
49osteoporosis, postmenopausal10.0TNFRSF11A, TNFRSF11B, TNFSF11
50tropical spastic paraparesis10.0IL2RB, IL2RA

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to polyarticular onset juvenile idiopathic arthritis

Clinical Features for Polyarticular Onset Juvenile Idiopathic Arthritis

About this section
Sources:
48Orphanet
See all sources


Symptoms:

48 (show all 9)
  • autoimmunity/autoimmune reaction/autoantibodies
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • micrognathia/retrognathia/micrognathism/retrognathism
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • joint/articular deformation
  • restricted joint mobility/joint stiffness/ankylosis
  • arthritis/synovitis/synovial proliferation
  • hydrarthrosis/articular/joint effusion
  • articular/joint pain/arthralgia

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Polyarticular Onset Juvenile Idiopathic Arthritis

Drug clinical trials:

Search ClinicalTrials for Polyarticular Onset Juvenile Idiopathic Arthritis

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Search CenterWatch for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

About this section

Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

32
Bone, Eye

Animal Models for Polyarticular Onset Juvenile Idiopathic Arthritis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.9PTPN2
2MP:00053907.3PTPN2, TYK2, FAS, TNFRSF11B, TNFSF11, TNFRSF11A
3MP:00053786.7TNFSF11, TNFRSF11B, FAS, IL2RA, IL2RB, PTPN22
4MP:00053975.8TNFRSF11A, CD247, PTPN2, PTPN22, IL2RB, IL2RA
5MP:00053875.8IL2RA, IL2RB, PTPN22, PTPN2, CD247, TYK2
6MP:00053845.7TYK2, STAT4, FAS, TNFRSF11B, TNFSF11, TNFRSF11A
7MP:00107685.6PTPN2, PTPN22, IL2RB, IL2RA, CD247, TYK2

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

About this section

Genetic Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

About this section

Expression for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

About this section
Sources:
53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore, 51QIAGEN, 29KEGG, 55SinoBiological
See all sources

Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5IL2RB, TYK2, IL2RA
2
Hide members
9.5TYK2, IL2RA, IL2RB
39.5IL2RB, IL2RA, TYK2
49.4IL2RA, CD247, STAT4
59.4TYK2, IL2RA, STAT4
6
Hide members
9.4IL2RB, IL2RA, FAS
7
Hide members
9.2IL2RB, TYK2, IL2RA, PTPN2
89.1TNFRSF11B, TNFSF11
99.1CD247, IL2RB, IL2RA, STAT4
10
Hide members
9.1IL2RB, TYK2, STAT4, IL2RA
119.1IL2RB, IL2RA, STAT4, TYK2
129.1STAT4, IL2RB, TYK2, IL2RA
13
Hide members
9.0IL2RA, TYK2, FAS, IL2RB
148.8TNFSF11, FAS, TNFRSF11A
158.8TNFSF11, FAS, TNFRSF11A
16
Hide members
8.7IL2RA, CD247, TYK2, STAT4, IL2RB
17
Hide members
8.6STAT4, TNFSF11, TNFRSF11A, IL2RB
188.5FAS, IL2RA, PTPN22, IL2RB, TNFSF11
198.5TNFRSF11B, TNFSF11, TNFRSF11A
20
Hide members
8.5TNFRSF11B, TNFSF11, TNFRSF11A
21
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
8.5TNFRSF11B, TNFSF11, TNFRSF11A
22
Hide members
8.5TNFRSF11A, TNFSF11, TNFRSF11B
23
Hide members
8.3TNFRSF11A, TNFSF11, STAT4, IL2RA, IL2RB
24
Hide members
8.2PTPN2, PTPN22, IL2RB, TNFRSF11A, TNFSF11, IL2RA
258.1TNFRSF11A, TNFSF11, TNFRSF11B, TYK2
26
Hide members
8.0TNFRSF11A, FAS, TNFSF11, TNFRSF11B
27
Hide members
7.6TNFRSF11A, CD247, TNFSF11, TNFRSF11B, FAS
28
Hide members
7.0IL2RB, FAS, TNFRSF11B, TYK2, TNFSF11, TNFRSF11A

Compounds for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1lentinan4410.3IL2RB, IL2RA
2mycophenolate4410.3IL2RB, IL2RA
3thymoglobulin4410.2IL2RB, IL2RA
4denileukin diftitox44 49 1112.2IL2RA, IL2RB
5Aldesleukin1110.1IL2RB, IL2RA
6daclizumab44 1110.9IL2RB, IL2RA
7rantes449.8FAS, IL2RA, IL2RB
8delta9-tetrahydrocannabinol449.8IL2RB, IL2RA
9okt3449.8IL2RB, IL2RA, FAS
10ivig449.7FAS, IL2RA, IL2RB
11hcc-1449.5TNFRSF11B, TNFSF11
12ifn-alpha449.4FAS, IL2RB, TYK2, IL2RA
13phosphotyrosine449.4IL2RB, TYK2, PTPN2, STAT4
14teriparatide44 1110.3TNFSF11, TNFRSF11B
15laccer449.3TNFRSF11A, TNFSF11
16melatonin44 59 28 11 2413.3IL2RB, IL2RA, TNFRSF11B
1725-hydroxyvitamin d449.2TNFRSF11B, IL2RA, TNFSF11
18ibandronate44 1110.2TNFRSF11B, TNFSF11
19etanercept44 49 1111.2TNFSF11, TNFRSF11B, IL2RB
20n acetylcysteine449.2TNFSF11, IL2RB, FAS, IL2RA
21rapamycin449.1IL2RB, TNFSF11, IL2RA, FAS
22dexamethasone44 49 28 1112.1TNFSF11, TNFRSF11B, FAS
233-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.0FAS, TNFRSF11B, TNFSF11
24azathioprine44 49 2 1112.0TNFRSF11B, TNFSF11, IL2RA, IL2RB
25prednisolone44 28 1111.0TNFRSF11B, FAS, IL2RB, IL2RA
26denosumab44 1110.0TNFSF11, TNFRSF11A, TNFRSF11B
27polyethylene448.9TNFRSF11A, TNFRSF11B, TNFSF11
28aspirin44 49 28 2411.9IL2RB, FAS, IL2RA, TNFRSF11B
29methotrexate44 49 1110.9IL2RB, TNFSF11, TNFRSF11B, IL2RA
30raloxifene44 28 49 1111.9TNFSF11, TNFRSF11B, TNFRSF11A
31arginine448.9FAS, PTPN2, CD247, PTPN22, IL2RB, IL2RA
32vitamin k2448.8TNFRSF11B, TNFSF11
33hydroxyapatite448.8TNFRSF11B, TNFSF11, TNFRSF11A
34creatinine448.7IL2RB, TNFRSF11B, TNFSF11, FAS
35ascorbic acid44 249.6FAS, TNFSF11, TNFRSF11B, IL2RA
36serine448.6TNFRSF11A, IL2RB, TNFRSF11B, TNFSF11
371,25 dihydroxy vitamin d3448.6IL2RB, TNFRSF11B, TNFSF11, TNFRSF11A
38vitamin d448.6TNFSF11, FAS, TNFRSF11B, IL2RA
39calcitriol44 59 11 2411.6IL2RA, TNFRSF11B, TNFSF11, TNFRSF11A
40doxorubicin44 49 1110.5IL2RA, TNFSF11, TNFRSF11B, FAS
41infliximab44 49 1110.5TNFRSF11B, IL2RB, IL2RA, FAS, TNFSF11
42genistein44 28 59 2 11 2413.4IL2RB, TNFSF11, TNFRSF11B, IL2RA, FAS
43cyclosporin a44 28 5910.4TNFRSF11B, IL2RB, FAS, IL2RA, TNFSF11
44ly294002448.4FAS, TNFRSF11B, TNFSF11, TYK2
45pge2448.3TNFSF11, IL2RB, TNFRSF11A, TNFRSF11B, IL2RA
46vegf447.8TNFRSF11B, IL2RB, IL2RA, TNFRSF11A, TNFSF11, FAS
47gp 130447.8TNFSF11, TNFRSF11A, FAS, IL2RA, TYK2, TNFRSF11B
48nitric oxide44 11 249.7TNFRSF11A, TNFSF11, TNFRSF11B, IL2RB, FAS
49phosphatidylinositol446.7TNFRSF11A, TNFSF11, FAS, STAT4, TYK2, CD247
50tyrosine446.1STAT4, TNFSF11, TNFRSF11B, FAS, TYK2, CD247

GO Terms for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7IL2RB, IL2RA, FAS, TNFRSF11A

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of T cell receptor signaling pathwayGO:05086010.0PTPN2, PTPN22
2T cell differentiationGO:0302179.9PTPN22, PTPN2
3activation-induced cell death of T cellsGO:0069249.8FAS, IL2RA
4positive regulation of fever generation by positive regulation of prostaglandin secretionGO:0718129.6TNFSF11, TNFRSF11A
5TNFSF11-mediated signaling pathwayGO:0718479.5TNFSF11, TNFRSF11A
6positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:0718489.5TNFRSF11A, TNFSF11
7mammary gland alveolus developmentGO:0607499.4TNFRSF11A, TNFSF11
8monocyte chemotaxisGO:0025489.3TNFSF11, TNFRSF11A
9osteoclast differentiationGO:0303169.2TNFSF11, TNFRSF11A
10tumor necrosis factor-mediated signaling pathwayGO:0332099.0TNFRSF11A, TNFSF11
11cytokine-mediated signaling pathwayGO:0192218.8TNFSF11, PTPN2, IL2RB, TYK2, STAT4

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 bindingGO:0199769.9IL2RA, IL2RB
2interleukin-2 receptor activityGO:0049119.8IL2RA, IL2RB
3transmembrane signaling receptor activityGO:0048888.7TNFRSF11A, FAS, CD247
4receptor activityGO:0048728.5TNFRSF11A, TNFRSF11B, FAS

Products for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet