MCID: PLY065
MIFTS: 36

Polyarticular Onset Juvenile Idiopathic Arthritis malady

Rare diseases, Eye diseases, Respiratory diseases, Bone diseases categories

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Sources:
65UMLS, 45NIH Rare Diseases, 51Orphanet, 28ICD10 via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Polyarticular Onset Juvenile Idiopathic Arthritis:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 45
Polyarticular Juvenile Rheumatoid Arthritis 45 65
Juvenile Polyarthritis Rheumatoid Factor Positive 45
Juvenile Polyarthritis Rheumatoid Factor Negative 45
Juvenile Rheumatoid Factor-Negative Polyarthritis 51
 
Juvenile Rheumatoid Factor-Positive Polyarthritis 51
Polyarthritis Without Rheumatoid Factor 51
Polyarthritis with Rheumatoid Factor 51
Juvenile Chronic Polyarthritis 65


Classifications:



Characteristics (Orphanet epidemiological data):

51
juvenile rheumatoid factor-negative polyarthritis:
Inheritance: Multigenic/multifactorial; Age of death: normal life expectancy
juvenile rheumatoid factor-positive polyarthritis:
Age of onset: Childhood; Age of death: normal life expectancy


External Ids:

Orphanet51 85408, 85435
ICD10 via Orphanet28 M08.3, M08.0
ICD1027 M13.0

Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards based summary: Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to rheumatoid arthritis and systemic lupus erythematosus, and has symptoms including abnormality of the teeth, arthritis and limitation of joint mobility. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is PTPN2 (Protein Tyrosine Phosphatase, Non-Receptor Type 2), and among its related pathways are Inflammatory Response Pathway and TSLP Signaling Pathway. Affiliated tissues include bone and eye, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

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Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis30.4IL2RA, IL2RB, PTPN22, STAT4, TNFRSF11A, TNFRSF11B
2systemic lupus erythematosus29.6CD247, FAS, IL2RA, PTPN22, STAT4
3juvenile rheumatoid arthritis11.0
4juvenile rheumatoid factor-negative polyarthritis without anti-nuclear antibodies10.7
5juvenile rheumatoid factor-negative polyarthritis with anti-nuclear antibodies10.7
6arthritis10.4
7aortic valve insufficiency10.4
8lupus erythematosus10.4
9endotheliitis10.4
10peripheral nerve schwannoma10.2TNFRSF11A, TNFRSF11B
11dyskinesia of esophagus10.2TNFRSF11B, TNFSF11
12pericardial effusion10.2TNFRSF11B, TNFSF11
13atrial fibrillation, familial, 810.2TNFRSF11A, TNFSF11
14paget disease of bone 2, early-onset10.2TNFRSF11A, TNFRSF11B, TNFSF11
15hemorrhagic fever10.2TNFRSF11A, TNFRSF11B, TNFSF11
16paget disease of bone 5, juvenile-onset10.2TNFRSF11A, TNFRSF11B, TNFSF11
17toxoplasmosis10.2TNFRSF11A, TNFRSF11B, TNFSF11
18primary syphilis10.2TNFRSF11A, TNFRSF11B, TNFSF11
19marcus gunn phenomenon10.2TNFRSF11A, TNFRSF11B, TNFSF11
20methylmalonic aciduria and homocystinuria type cble10.2TNFRSF11A, TNFRSF11B, TNFSF11
21jaw cancer10.2TNFRSF11A, TNFRSF11B, TNFSF11
22bone structure disease10.2TNFRSF11A, TNFRSF11B, TNFSF11
23hyperostosis, endosteal10.1TNFRSF11A, TNFRSF11B, TNFSF11
24pulmonary type ovarian small cell carcinoma10.1TNFRSF11B, TNFSF11
25aapoai amyloidosis10.1PTPN22, STAT4
26gingival disease10.1TNFRSF11A, TNFRSF11B, TNFSF11
27bone deterioration disease10.1TNFRSF11A, TNFRSF11B, TNFSF11
28schwannoma of jugular foramen10.1TNFRSF11A, TNFRSF11B, TNFSF11
29bone resorption disease10.1TNFRSF11A, TNFRSF11B, TNFSF11
30plummer's disease10.1TNFRSF11B, TNFSF11
31anterior cruciate ligament tears10.1TNFRSF11B, TNFSF11
32psoriatic arthritis10.1PTPN22, TNFRSF11B, TNFSF11
33cutaneous leishmaniasis10.0PTPN2, PTPN22, STAT4
34lymphomatous thyroiditis10.0FAS, TYK2
35limited scleroderma10.0IL2RA, PTPN22
36asphyxia neonatorum9.9PTPN22, STAT4, TNFRSF11A, TNFSF11
37hypersensitivity reaction type iii disease9.9IL2RA, PTPN22, STAT4
38alternating esotropia9.9IL2RA, STAT4
39bone marrow cancer9.8IL2RA, IL2RB, PTPN22, STAT4
40congenital heart block9.8FAS, IL2RA, IL2RB
41lymphoma, non-hodgkin9.8FAS, IL2RA, IL2RB
42constipation9.7IL2RA, PTPN22, STAT4, TNFRSF11A, TNFSF11
43wild type abeta2m amyloidosis8.8ANKRD55, CD247, FAS, IL2RA, IL2RB, PTPN2
44polycystic bone disease8.4ANKRD55, CD247, FAS, IL2RA, IL2RB, PTPN2

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to polyarticular onset juvenile idiopathic arthritis

Symptoms for Polyarticular Onset Juvenile Idiopathic Arthritis

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Symptoms:

 51 (show all 9)
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • joint/articular deformation
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • micrognathia/retrognathia/micrognathism/retrognathism

HPO human phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

(show all 9)
id Description Frequency HPO Source Accession
1 abnormality of the teeth hallmark (90%) HP:0000164
2 arthritis hallmark (90%) HP:0001369
3 limitation of joint mobility hallmark (90%) HP:0001376
4 joint swelling hallmark (90%) HP:0001386
5 arthralgia hallmark (90%) HP:0002829
6 autoimmunity hallmark (90%) HP:0002960
7 abnormality of the teeth typical (50%) HP:0000164
8 micrognathia typical (50%) HP:0000347
9 autoimmunity occasional (7.5%) HP:0002960

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

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Drugs for Polyarticular Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AdalimumabapprovedPhase 3411331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
2
MethotrexateapprovedPhase 313871959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
Methopterin
Methotextrate
 
Methotrate
Methotrexat
Methotrexate
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metoject
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Otrexup
Rasuvo
Rheumatrex
Rheumatrex Dose Pack
Trexall
3
AbataceptapprovedPhase 3130332348-12-610237
Synonyms:
CTLA4-Ig
CTLA4-IgG4m
 
CTLA4Ig
CTLA4IgG4m
Orencia
4
InfliximabapprovedPhase 3327170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
5
Folic Acidapproved, nutraceuticalPhase 3285159-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
6Vitamin B ComplexPhase 32775
7TNFR-Fc fusion proteinPhase 3367
8Vitamin B9NutraceuticalPhase 32851
9FolateNutraceuticalPhase 32851
10Folinic AcidNutraceuticalPhase 32498

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid ArthritisCompletedNCT00690573Phase 3
2A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Juvenile Rheumatoid ArthritisCompletedNCT00036374Phase 3
3BMS-188667 in Children and Adolescents With Juvenile Rheumatoid ArthritisCompletedNCT00095173Phase 3
4Study of Human Anti-TNF Monoclonal Antibody Adalimumab in Children With Polyarticular Juvenile Idiopathic Arthritis (JIA)CompletedNCT00048542Phase 3
5A Study to Evaluate the Pharmacokinetics, Efficacy and Safety of Intravenous Golimumab in Pediatric Participants With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate TherapyRecruitingNCT02277444Phase 3
6Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid ArthritisTerminatedNCT00078806Phase 3
7Ultrasonography in Juvenile Idiopathic ArthritisCompletedNCT01304420Phase 0
8Start Time Optimization of Biologics in Polyarticular JIARecruitingNCT02593006

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

33
Bone, Eye

Animal Models for Polyarticular Onset Juvenile Idiopathic Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.1FAS, PTPN2, TNFRSF11A, TNFRSF11B, TNFSF11
2MP:00053797.8FAS, IL2RB, PTPN22, STAT4, TNFRSF11A, TNFSF11
3MP:00053907.8FAS, PTPN2, TNFRSF11A, TNFRSF11B, TNFSF11, TYK2
4MP:00053786.5FAS, IL2RA, IL2RB, PTPN2, PTPN22, TNFRSF11A
5MP:00107685.8CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22
6MP:00053875.7CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22
7MP:00053975.5CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? (18802807)
2008

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL2RA, IL2RB
29.8IL2RA, STAT4
39.4IL2RA, STAT4, TYK2
4
Show member pathways
9.4FAS, IL2RA, IL2RB
59.3TNFRSF11B, TNFSF11
69.3CD247, IL2RA, STAT4
7
Show member pathways
9.1FAS, IL2RA, IL2RB, TYK2
8
Show member pathways
9.0CD247, IL2RA, IL2RB, STAT4
9
Show member pathways
8.9IL2RA, IL2RB, PTPN2, STAT4, TYK2
108.7FAS, TNFRSF11A, TNFSF11
11
Show member pathways
8.7CD247, IL2RA, IL2RB, STAT4, TYK2
12
Show member pathways
8.7CD247, IL2RA, IL2RB, STAT4, TYK2
138.5TNFRSF11A, TNFRSF11B, TNFSF11
148.5TNFRSF11A, TNFRSF11B, TNFSF11
158.2TNFRSF11A, TNFRSF11B, TNFSF11, TYK2
16
TNF Signaling (sino)
Show member pathways
8.1TNFRSF11A, TNFRSF11B, TNFSF11, TYK2
17
Show member pathways
8.1FAS, TNFRSF11A, TNFRSF11B, TNFSF11
18
Show member pathways
7.5FAS, IL2RA, IL2RB, PTPN2, PTPN22, TNFRSF11A
19
Show member pathways
7.4CD247, FAS, PTPN2, TNFRSF11A, TNFRSF11B, TNFSF11
20
Show member pathways
7.3CD247, FAS, IL2RA, IL2RB, STAT4, TNFRSF11A
217.1FAS, IL2RA, IL2RB, PTPN22, STAT4, TNFRSF11A
22
Show member pathways
6.8CD247, IL2RA, IL2RB, PTPN2, TNFRSF11A, TNFRSF11B
23
Show member pathways
6.6CD247, FAS, IL2RA, IL2RB, TNFRSF11A, TNFRSF11B

GO Terms for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.6FAS, IL2RA, IL2RB, TNFRSF11A

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1interleukin-2-mediated signaling pathwayGO:003811010.5IL2RA, IL2RB
2negative regulation of T cell receptor signaling pathwayGO:005086010.5PTPN2, PTPN22
3T cell differentiationGO:003021710.4PTPN2, PTPN22
4activation-induced cell death of T cellsGO:000692410.3FAS, IL2RA
5T cell homeostasisGO:004302910.2FAS, IL2RA
6positive regulation of fever generation by positive regulation of prostaglandin secretionGO:00718129.7TNFRSF11A, TNFSF11
7TNFSF11-mediated signaling pathwayGO:00718479.7TNFRSF11A, TNFSF11
8positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:00718489.7TNFRSF11A, TNFSF11
9osteoclast differentiationGO:00303169.5TNFRSF11A, TNFSF11
10mammary gland alveolus developmentGO:00607499.2TNFRSF11A, TNFSF11
11regulation of cell proliferationGO:00421279.0FAS, TNFRSF11B, TYK2
12response to lipopolysaccharideGO:00324968.9FAS, TNFRSF11A, TNFRSF11B
13apoptotic signaling pathwayGO:00971908.9FAS, TNFRSF11A, TNFRSF11B
14cytokine-mediated signaling pathwayGO:00192218.7IL2RB, PTPN2, STAT4, TNFSF11, TYK2
15immune responseGO:00069558.7FAS, IL2RA, TNFRSF11B, TNFSF11
16tumor necrosis factor-mediated signaling pathwayGO:00332098.6FAS, TNFRSF11A, TNFRSF11B, TNFSF11
17inflammatory responseGO:00069548.4FAS, IL2RA, TNFRSF11A, TNFRSF11B

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:000491110.6IL2RA, IL2RB
2interleukin-2 bindingGO:001997610.6IL2RA, IL2RB
3tumor necrosis factor-activated receptor activityGO:00050319.3FAS, TNFRSF11A, TNFRSF11B
4receptor activityGO:00048729.0FAS, TNFRSF11A, TNFRSF11B
5protein bindingGO:00055155.2ANKRD55, CD247, FAS, IL2RA, IL2RB, PTPN2

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet