MCID: PLY065
MIFTS: 41

Polyarticular Onset Juvenile Idiopathic Arthritis malady

Categories: Rare diseases, Eye diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Sources:
66UMLS, 46NIH Rare Diseases, 52Orphanet, 29ICD10 via Orphanet, 28ICD10
See all MalaCards sources

Aliases & Descriptions for Polyarticular Onset Juvenile Idiopathic Arthritis:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 46
Polyarticular Juvenile Rheumatoid Arthritis 46 66
Juvenile Polyarthritis Rheumatoid Factor Negative 46
Juvenile Polyarthritis Rheumatoid Factor Positive 46
Juvenile Rheumatoid Factor-Positive Polyarthritis 52
 
Juvenile Rheumatoid Factor-Negative Polyarthritis 52
Polyarthritis Without Rheumatoid Factor 52
Polyarthritis with Rheumatoid Factor 52
Juvenile Chronic Polyarthritis 66

Characteristics:

Orphanet epidemiological data:

52
juvenile rheumatoid factor-negative polyarthritis:
Inheritance: Multigenic/multifactorial; Age of death: normal life expectancy
juvenile rheumatoid factor-positive polyarthritis:
Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

ICD10 via Orphanet29 M08.3, M08.0
ICD1028 M13.0

Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards based summary: Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to rheumatoid arthritis and juvenile rheumatoid factor-negative polyarthritis without anti-nuclear antibodies, and has symptoms including abnormality of the teeth, arthritis and limitation of joint mobility. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is PTPN2 (Protein Tyrosine Phosphatase, Non-Receptor Type 2), and among its related pathways are Inflammatory Response Pathway and TSLP Signaling Pathway. Affiliated tissues include bone and eye, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

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Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis29.5IL2RA, PTPN22, STAT4, TNFRSF11A, TNFRSF11B, TNFSF11
2juvenile rheumatoid factor-negative polyarthritis without anti-nuclear antibodies12.5
3juvenile rheumatoid factor-negative polyarthritis with anti-nuclear antibodies12.5
4juvenile rheumatoid arthritis11.8
5myopia10.5TNFRSF11B, TNFSF11
6solar retinopathy10.5TNFRSF11B, TNFSF11
7toxoplasmosis10.5TNFRSF11A, TNFRSF11B
8osteopetrosis, autosomal recessive 710.4TNFRSF11A, TNFRSF11B, TNFSF11
9hemorrhagic shock and encephalopathy syndrome10.4TNFRSF11A, TNFRSF11B, TNFSF11
10tibial hemimelia10.4TNFRSF11A, TNFRSF11B, TNFSF11
11inflammatory liposarcoma10.3TNFRSF11A, TNFRSF11B, TNFSF11
12pneumatosis cystoides intestinalis10.3TNFRSF11A, TNFRSF11B, TNFSF11
13anaerobic meningitis10.3TNFRSF11A, TNFRSF11B, TNFSF11
14bone resorption disease10.3TNFRSF11A, TNFRSF11B, TNFSF11
15chromosome 16q22 deletion syndrome10.3TNFRSF11A, TNFSF11
16physical disorder10.3TNFRSF11A, TNFRSF11B, TNFSF11
17bone deterioration disease10.3TNFRSF11A, TNFRSF11B, TNFSF11
18neuroma10.3TNFRSF11A, TNFRSF11B, TNFSF11
19cannabis dependence10.3TNFRSF11A, TNFRSF11B, TNFSF11
20lung occult small cell carcinoma10.2TNFRSF11A, TNFRSF11B, TNFSF11
21xanthomatosis10.2PTPN22, TNFRSF11B, TNFSF11
22bacillary angiomatosis10.2TNFRSF11B, TNFSF11
23juvenile sialidosis type 210.2PTPN22, STAT4
24leprosy 410.1PTPN22, TNFRSF11B, TNFSF11
25arthritis10.1
26acquired hyperkeratosis10.0TNFRSF11B, TNFSF11
27atherosclerosis9.8PTPN22, STAT4, TNFRSF11A, TNFSF11
28steroid dehydrogenase deficiency dental anomalies9.8FAS, TYK2
29goodpasture syndrome9.5FAS, IL2RA, STAT4
30smoking as a quantitative trait locus 19.4FAS, IL2RA, IL2RB
31systemic lupus erythematosus8.4CD247, FAS, IL2RA, PTPN22, STAT4
32benign adult familial myoclonic epilepsy6.9ANKRD55, CD247, FAS, IL2RA, IL2RB, PTPN2
33juvenile retinoschisis6.1ANKRD55, CD247, FAS, IL2RA, IL2RB, PTPN2

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to polyarticular onset juvenile idiopathic arthritis

Symptoms for Polyarticular Onset Juvenile Idiopathic Arthritis

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Symptoms:

 52 (show all 13)
  • dental malocclusion
  • joint dislocation
  • limitation of joint mobility
  • joint swelling
  • apraxia
  • arthralgia
  • antinuclear antibody positivity
  • elevated erythrocyte sedimentation rate
  • juvenile rheumatoid arthritis
  • polyarticular arthritis
  • elevated c-reactive protein level
  • rheumatoid factor positive
  • abnormality of the temporomandibular joint

HPO human phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

(show all 9)
id Description Frequency HPO Source Accession
1 abnormality of the teeth hallmark (90%) HP:0000164
2 arthritis hallmark (90%) HP:0001369
3 limitation of joint mobility hallmark (90%) HP:0001376
4 joint swelling hallmark (90%) HP:0001386
5 arthralgia hallmark (90%) HP:0002829
6 autoimmunity hallmark (90%) HP:0002960
7 abnormality of the teeth typical (50%) HP:0000164
8 micrognathia typical (50%) HP:0000347
9 autoimmunity occasional (7.5%) HP:0002960

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

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Drugs for Polyarticular Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MethotrexatePhase 314961959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
2
AbataceptPhase 3188332348-12-610237
Synonyms:
CTLA4-Ig
 
CTLA4-IgG4m
CTLA4Ig
CTLA4IgG4m
3
adalimumabPhase 3466331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
4
infliximabPhase 3364170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
5
EtanerceptPhase 3391185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
6FolateNutraceuticalPhase 34143
7
Folic AcidNutraceuticalPhase 3414359-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid ArthritisCompletedNCT00690573Phase 3
2A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Juvenile Rheumatoid ArthritisCompletedNCT00036374Phase 3
3BMS-188667 in Children and Adolescents With Juvenile Rheumatoid ArthritisCompletedNCT00095173Phase 3
4Study of Human Anti-TNF Monoclonal Antibody Adalimumab in Children With Polyarticular Juvenile Idiopathic Arthritis (JIA)CompletedNCT00048542Phase 3
5A Study to Evaluate the Pharmacokinetics, Efficacy and Safety of Intravenous Golimumab in Pediatric Participants With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate TherapyRecruitingNCT02277444Phase 3
6Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid ArthritisTerminatedNCT00078806Phase 3
7Ultrasonography in Juvenile Idiopathic ArthritisCompletedNCT01304420Phase 0
8Start Time Optimization of Biologics in Polyarticular JIARecruitingNCT02593006

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

34
Bone, Eye

Animal Models for Polyarticular Onset Juvenile Idiopathic Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053717.8FAS, PTPN2, TNFRSF11A, TNFRSF11B, TNFSF11
2MP:00053797.0CD247, FAS, IL2RB, PTPN2, PTPN22, STAT4
3MP:00053786.2FAS, IL2RA, IL2RB, PTPN2, PTPN22, TNFRSF11A
4MP:00053876.1CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22
5MP:00053975.9CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22
6MP:00107685.8CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? (18802807)
2008

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL2RA, IL2RB
29.8IL2RA, STAT4
39.5PTPN2, STAT4, TYK2
49.5IL2RA, IL2RB, STAT4
5
Show member pathways
9.4IL2RA, STAT4, TYK2
6
Show member pathways
9.4FAS, IL2RA, IL2RB
79.3TNFRSF11B, TNFSF11
89.3CD247, IL2RA, STAT4
99.2IL2RA, IL2RB, STAT4, TYK2
10
Show member pathways
9.1FAS, IL2RA, IL2RB, TYK2
11
Show member pathways
9.0CD247, IL2RA, IL2RB, STAT4
12
Show member pathways
8.9IL2RA, IL2RB, PTPN2, STAT4, TYK2
138.7FAS, TNFRSF11A, TNFSF11
14
Show member pathways
8.7CD247, IL2RA, IL2RB, STAT4, TYK2
15
Show member pathways
8.7CD247, IL2RA, IL2RB, STAT4, TYK2
168.5TNFRSF11A, TNFRSF11B, TNFSF11
178.5TNFRSF11A, TNFRSF11B, TNFSF11
188.2TNFRSF11A, TNFRSF11B, TNFSF11, TYK2
19
Show member pathways
8.1FAS, TNFRSF11A, TNFRSF11B, TNFSF11
20
Show member pathways
8.1FAS, TNFRSF11A, TNFRSF11B, TNFSF11
21
Show member pathways
7.5FAS, IL2RA, IL2RB, PTPN2, PTPN22, TNFRSF11A
22
Show member pathways
7.3CD247, FAS, IL2RA, IL2RB, STAT4, TNFRSF11A
236.8FAS, IL2RA, IL2RB, PTPN2, PTPN22, STAT4
24
Show member pathways
6.8CD247, IL2RA, IL2RB, PTPN2, TNFRSF11A, TNFRSF11B
25
Show member pathways
6.6CD247, FAS, IL2RA, IL2RB, TNFRSF11A, TNFRSF11B

GO Terms for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.6FAS, IL2RA, IL2RB, TNFRSF11A

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1interleukin-2-mediated signaling pathwayGO:003811010.5IL2RA, IL2RB
2negative regulation of T cell receptor signaling pathwayGO:005086010.5PTPN2, PTPN22
3T cell homeostasisGO:004302910.2FAS, IL2RA
4T cell differentiationGO:003021710.0PTPN2, PTPN22
5positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:00718489.8TNFRSF11A, TNFSF11
6positive regulation of fever generation by positive regulation of prostaglandin secretionGO:00718129.8TNFRSF11A, TNFSF11
7TNFSF11-mediated signaling pathwayGO:00718479.7TNFRSF11A, TNFSF11
8monocyte chemotaxisGO:00025489.6TNFRSF11A, TNFSF11
9osteoclast differentiationGO:00303169.5TNFRSF11A, TNFSF11
10mammary gland alveolus developmentGO:00607499.4TNFRSF11A, TNFSF11
11activation-induced cell death of T cellsGO:00069249.4FAS, IL2RA
12regulation of cell proliferationGO:00421279.2FAS, TNFRSF11B, TYK2
13regulation of apoptotic processGO:00429818.8FAS, TNFRSF11A, TNFRSF11B
14tumor necrosis factor-mediated signaling pathwayGO:00332098.6FAS, TNFRSF11A, TNFRSF11B, TNFSF11
15immune responseGO:00069558.5FAS, IL2RA, TNFRSF11B, TNFSF11
16apoptotic signaling pathwayGO:00971908.5FAS, TNFRSF11A, TNFRSF11B
17inflammatory responseGO:00069548.5FAS, IL2RA, TNFRSF11A, TNFRSF11B
18response to lipopolysaccharideGO:00324968.3FAS, PTPN22, TNFRSF11A, TNFRSF11B

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 bindingGO:001997610.4IL2RA, IL2RB
2interleukin-2 receptor activityGO:000491110.4IL2RA, IL2RB
3tumor necrosis factor-activated receptor activityGO:00050318.9FAS, TNFRSF11A, TNFRSF11B
4receptor activityGO:00048728.6FAS, TNFRSF11A, TNFRSF11B

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet