MCID: PLY065
MIFTS: 40

Polyarticular Onset Juvenile Idiopathic Arthritis malady

Rare diseases, Eye diseases, Respiratory diseases, Bone diseases categories

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Sources:
60UMLS, 41NIH Rare Diseases, 47Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Polyarticular Onset Juvenile Idiopathic Arthritis, Aliases & Descriptions:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 41
Polyarticular Juvenile Rheumatoid Arthritis 41 60
Juvenile Polyarthritis Rheumatoid Factor Positive 41
Juvenile Polyarthritis Rheumatoid Factor Negative 41
Juvenile Rheumatoid Factor-Negative Polyarthritis 47
 
Juvenile Rheumatoid Factor-Positive Polyarthritis 47
Polyarthritis Without Rheumatoid Factor 47
Polyarthritis with Rheumatoid Factor 47
Juvenile Chronic Polyarthritis 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

47
juvenile rheumatoid factor-negative polyarthritis:
Inheritance: Multigenic/multifactorial; Age of death: normal life expectancy
juvenile rheumatoid factor-positive polyarthritis:
Age of onset: Childhood; Age of death: normal life expectancy


External Ids:

Orphanet47 85408, 85435
ICD10 via Orphanet26 M08.3, M08.0
ICD1025 M13.0

Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards based summary: Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to juvenile rheumatoid arthritis and arthritis, and has symptoms including abnormality of the teeth, arthritis and limitation of joint mobility. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is CD247 (CD247 molecule), and among its related pathways are IL2-mediated signaling events and IL2 signaling events mediated by PI3K. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include bone and eye, and related mouse phenotypes are digestive/alimentary and cellular.

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

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Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile rheumatoid arthritis31.9IL2RB, IL2RA
2arthritis30.8IL2RB, PTPN22
3rheumatoid arthritis30.6TYK2, PTPN22, FAS, STAT4, IL2RA, IL2RB
4systemic lupus erythematosus29.5CD247, TYK2, PTPN22, FAS, STAT4, IL2RA
5juvenile rheumatoid factor-negative polyarthritis without anti-nuclear antibodies10.7
6juvenile rheumatoid factor-negative polyarthritis with anti-nuclear antibodies10.7
7uveitis10.5IL2RA
8aortic valve insufficiency10.4
9lupus erythematosus10.4
10endotheliitis10.4
11posterior uveitis10.3IL2RB, IL2RA
12thyroiditis10.3PTPN22
13tropical spastic paraparesis10.3IL2RA, IL2RB
14extrinsic allergic alveolitis10.3IL2RB, IL2RA
15acute graft versus host disease10.3IL2RB, IL2RA
16severe combined immunodeficiency, x-linked10.3IL2RB, IL2RA
17adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency10.3IL2RA, IL2RB
18common variable immunodeficiency10.3IL2RB, IL2RA
19hcl-v10.3IL2RA, IL2RB
20pulmonary sarcoidosis10.3IL2RA, IL2RB
21vogt-koyanagi-harada disease10.3IL2RA, FAS
22peripheral t-cell lymphoma10.3IL2RA, IL2RB
23pulmonary tuberculosis10.3IL2RA, CD247
24autoimmune lymphoproliferative syndrome10.2IL2RA, FAS
25mycosis fungoides10.2IL2RB, IL2RA
26anaplastic large cell lymphoma10.2IL2RA, IL2RB
27splenomegaly10.2IL2RA, FAS
28diphtheria10.2IL2RB, IL2RA
29hodgkin lymphoma10.2IL2RA, IL2RB, CD247
30sezary's disease10.2STAT4, IL2RA, IL2RB
31hepatitis10.1FAS, IL2RB
32cutaneous t cell lymphoma10.1FAS, IL2RA, IL2RB
33graft-versus-host disease, protection against10.1IL2RB, IL2RA, FAS
34severe combined immunodeficiency10.1TYK2, IL2RA, IL2RB
35chronic lymphocytic leukemia10.1IL2RB, IL2RA, FAS
36t-cell leukemia10.1IL2RB, IL2RA, FAS
37lymphoma, non-hodgkin10.1FAS, IL2RA, IL2RB
38systemic scleroderma10.0PTPN22, IL2RA, IL2RB
39sjogren's syndrome10.0FAS, IL2RA
40connective tissue disease10.0PTPN22, IL2RA
41hypersensitivity reaction type ii disease10.0PTPN22, IL2RA
42eosinophilia10.0IL2RB, IL2RA
43hashimoto thyroiditis10.0PTPN22, FAS, IL2RA
44graves' disease10.0PTPN22, FAS, IL2RA
45kidney cancer10.0FAS, IL2RA, IL2RB, CD247
46viral infectious disease10.0FAS, IL2RA, IL2RB, CD247
47multiple sclerosis, disease progression, modifier of9.9PTPN22, STAT4, IL2RA, IL2RB
48lymphopenia9.8PTPN22, FAS, IL2RA, IL2RB
49ipex syndrome9.8FAS, STAT4, IL2RA, IL2RB, CD247
50leukemia9.7TYK2, FAS, IL2RA, IL2RB, CD247

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to polyarticular onset juvenile idiopathic arthritis

Symptoms for Polyarticular Onset Juvenile Idiopathic Arthritis

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Symptoms:

 47 (show all 9)
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • joint/articular deformation
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • micrognathia/retrognathia/micrognathism/retrognathism

HPO human phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

(show all 9)
id Description Frequency HPO Source Accession
1 abnormality of the teeth hallmark (90%) HP:0000164
2 arthritis hallmark (90%) HP:0001369
3 limitation of joint mobility hallmark (90%) HP:0001376
4 joint swelling hallmark (90%) HP:0001386
5 arthralgia hallmark (90%) HP:0002829
6 autoimmunity hallmark (90%) HP:0002960
7 abnormality of the teeth typical (50%) HP:0000164
8 micrognathia typical (50%) HP:0000347
9 autoimmunity occasional (7.5%) HP:0002960

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

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Drug clinical trials:

Search ClinicalTrials for Polyarticular Onset Juvenile Idiopathic Arthritis

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

31
Bone, Eye

Animal Models for Polyarticular Onset Juvenile Idiopathic Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053817.8PTPN2, PTPN22, FAS, IL2RA
2MP:00053847.7CD247, FAS, PTPN22, PTPN2, TYK2
3MP:00053787.2TYK2, PTPN2, PTPN22, FAS, IL2RA, IL2RB
4MP:00053976.7CD247, TYK2, PTPN2, PTPN22, FAS, STAT4
5MP:00053876.6TYK2, PTPN2, PTPN22, FAS, STAT4, IL2RA
6MP:00107686.5TYK2, PTPN2, PTPN22, FAS, STAT4, IL2RA

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? (18802807)
2008

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL-2 Signaling pathway36
9.8IL2RB, IL2RA
2
Show member pathways
IL2 signaling events mediated by STAT536
9.8IL2RB, IL2RA
39.8IL2RB, IL2RA
4
Show member pathways
Immune response IL 3 activation and signaling pathway58
9.8IL2RB, IL2RA
59.7STAT4, IL2RA
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.5STAT4, TYK2
79.5TYK2, STAT4
8
Show member pathways
9.5TYK2, STAT4
9
Show member pathways
IL27-mediated signaling events36
9.5STAT4, TYK2
109.4CD247, IL2RA, STAT4
11
Show member pathways
9.3IL2RB, IL2RA, STAT4
12
Show member pathways
9.2FAS, IL2RA, IL2RB
13
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.2IL2RB, IL2RA, TYK2
14
Show member pathways
9.2IL2RB, IL2RA, TYK2
159.2TYK2, IL2RA, IL2RB
16
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.2FAS, STAT4, CD247
179.2IL2RA, STAT4, TYK2
18
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.0STAT4, IL2RA, IL2RB, CD247
19
Show member pathways
8.8TYK2, STAT4, IL2RA, IL2RB
20
Show member pathways
Type III interferon signaling36
8.8TYK2, STAT4, IL2RA, IL2RB
21
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.8CD247, FAS, PTPN2
22
Show member pathways
8.7IL2RB, IL2RA, FAS, TYK2
23
Show member pathways
8.7TYK2, FAS, IL2RA, IL2RB
248.6PTPN22, FAS, IL2RA, IL2RB
25
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
8.5TYK2, STAT4, IL2RA, IL2RB, CD247
26
Show member pathways
Immune response IL 12 induced IFN gamma production58
8.5CD247, IL2RB, IL2RA, STAT4, TYK2
27
Show member pathways
8.4TYK2, PTPN2, IL2RA, IL2RB
28
Show member pathways
8.3PTPN2, PTPN22, IL2RA, IL2RB

Compounds for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Compounds related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 49)
idCompoundScoreTop Affiliating Genes
1lentinan4310.2IL2RB, IL2RA
2mycophenolate4310.2IL2RB, IL2RA
3thymoglobulin4310.2IL2RA, IL2RB
4denileukin diftitox43 49 1212.2IL2RB, IL2RA
5delta9-tetrahydrocannabinol4310.2IL2RB, IL2RA
6daclizumab43 1211.2IL2RB, IL2RA
7basiliximab43 1211.2IL2RA, IL2RB
8alemtuzumab43 1211.2IL2RB, IL2RA
9levamisole43 1211.1IL2RB, IL2RA
10cuprophan4310.1IL2RB, IL2RA
11polysulfone4310.1IL2RB, IL2RA
12mycophenolic acid43 49 1212.1IL2RA, IL2RB
13phorbol 12,13-dibutyrate4310.1IL2RB, IL2RA
14fitc4310.1IL2RA, IL2RB
15con a4310.1IL2RA, IL2RB
162,5-oligoadenylate4310.0IL2RA, IL2RB
17mycophenolate mofetil43 49 1212.0IL2RB, IL2RA
18il 104310.0IL2RB, IL2RA
19erythromycin43 2 49 1213.0IL2RB, IL2RA
20lactose43 1211.0IL2RB, IL2RA
21pentoxifylline43 1210.9IL2RB, IL2RA
222-chlorodeoxyadenosine439.9FAS, IL2RA
23neopterin439.9IL2RB, IL2RA
24okt3439.7FAS, IL2RA, IL2RB
25infliximab43 49 1211.7IL2RB, IL2RA, FAS
26ivig439.7IL2RB, IL2RA, FAS
27prednisolone43 28 1211.7FAS, IL2RA, IL2RB
28ionomycin439.6IL2RB, IL2RA, FAS
29aspirin43 49 28 2412.6IL2RB, IL2RA, FAS
30rantes439.6FAS, IL2RA, IL2RB
31n acetylcysteine439.6IL2RB, IL2RA, FAS
32anisomycin43 1210.6IL2RA, FAS
33polysaccharide439.6IL2RB, IL2RA, FAS
34rapamycin439.5IL2RB, IL2RA, FAS
35genistein43 28 59 2 24 1214.5IL2RB, IL2RA, FAS
36gp 130439.5IL2RA, FAS, TYK2
37cyclosporin a43 28 5911.5FAS, IL2RA, IL2RB
38melatonin43 28 59 24 1213.5IL2RB, IL2RA
39thymidine43 2410.4FAS, IL2RA, IL2RB
40cisplatin43 49 59 1212.3IL2RB, IL2RA, FAS
41creatinine439.2FAS, IL2RA, IL2RB
42dexamethasone43 49 28 1212.2IL2RB, IL2RA, STAT4, FAS
43ifn-alpha439.2TYK2, FAS, IL2RA, IL2RB
44aspartate439.1IL2RB, IL2RA, FAS
45phosphotyrosine438.8TYK2, PTPN2, STAT4, IL2RB
46phosphatidylinositol438.4TYK2, FAS, STAT4, IL2RA, IL2RB, CD247
47serine438.2TYK2, PTPN2, FAS, STAT4, IL2RB
48arginine437.9PTPN2, PTPN22, FAS, IL2RA, IL2RB, CD247
49tyrosine437.0CD247, TYK2, PTPN2, PTPN22, FAS, STAT4

GO Terms for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.2IL2RB, IL2RA, FAS

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1activation-induced cell death of T cellsGO:00069249.6IL2RA, FAS
2negative regulation of inflammatory responseGO:00507289.3IL2RA, PTPN2
3negative regulation of T cell receptor signaling pathwayGO:00508609.0PTPN2, PTPN22
4T cell differentiationGO:00302178.9PTPN22, PTPN2
5peptidyl-tyrosine dephosphorylationGO:00353358.7PTPN22, PTPN2
6cytokine-mediated signaling pathwayGO:00192218.5IL2RB, STAT4, PTPN2, TYK2

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:00049119.8IL2RB, IL2RA
2interleukin-2 bindingGO:00199769.7IL2RB, IL2RA
3kinase bindingGO:00199009.0FAS, PTPN22
4protein tyrosine phosphatase activityGO:00047259.0PTPN22, PTPN2

Products for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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  • Antibodies
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  • Kits and Assays

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet