MCID: PLY065
MIFTS: 39

Polyarticular Onset Juvenile Idiopathic Arthritis malady

Eye, Respiratory, Bone categories

Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

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33MalaCards
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MalaCards: Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to arthritis and vascular disease, and has symptoms including joint/articular deformation, joint/articular deformation and abnormal dentition/dental position/implantation/unerupted/dental ankylosis. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Tyrosine Kinases / Adaptors. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and skeleton.

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

Sources:
43NIH Rare Diseases, 61UMLS, 49Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye, Respiratory, Bone


Characteristics (Orphanet epidemiological data):

49
juvenile rheumatoid factor-negative polyarthritis:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000; Age of death: Normal
juvenile rheumatoid factor-positive polyarthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

polyarticular onset juvenile idiopathic arthritis 43
polyarticular juvenile rheumatoid arthritis 43 61
juvenile polyarthritis rheumatoid factor negative 43
juvenile polyarthritis rheumatoid factor positive 43
juvenile rheumatoid factor-negative polyarthritis 49
juvenile rheumatoid factor-positive polyarthritis 49
polyarthritis without rheumatoid factor 49
polyarthritis with rheumatoid factor 49


External Ids:

ICD10 via Orphanet26 M08.3, M08.0
ICD1025 M13.0

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.6TNFRSF11A, TNFRSF11B, IL2RB, PTPN22, TNFSF11
2vascular disease30.5TNFRSF11B, TNFSF11, TNFRSF11A
3systemic lupus erythematosus30.5IL2RB, IL2RA, PTPN22, CD247, FAS, STAT4
4juvenile rheumatoid arthritis11.0
5juvenile rheumatoid factor-negative polyarthritis without anti-nuclear antibodies10.5
6juvenile rheumatoid factor-negative polyarthritis with anti-nuclear antibodies10.5
7aortic valve insufficiency10.4
8mannose-binding lectin deficiency10.4
9root resorption10.0TNFRSF11B
10paget's disease of bone10.0TNFRSF11A
11crohn's disease10.0PTPN2
12periodontitis10.0TNFRSF11B
13uveitis10.0IL2RA
14lupus nephritis10.0IL2RA
15cystic fibrosis10.0TNFRSF11B
16thyroiditis10.0PTPN22
17hemophagocytic lymphohistiocytosis10.0IL2RA
18celiac disease10.0PTPN22
19acute myocardial infarction10.0TNFSF11
20hyperthyroidism10.0PTPN22
21uremia10.0TNFRSF11B
22giant cell tumor10.0TNFSF11
23hepatitis10.0IL2RB
24obesity10.0PTPN2
25diabetes mellitus10.0PTPN22
26tuberculosis10.0IL2RA
27arthropathy10.0TNFRSF11B, TNFSF11
28synovitis10.0TNFSF11, TNFRSF11B
29multiple myeloma10.0TNFRSF11B, TNFSF11
30osteosclerosis10.0TNFRSF11B, TNFSF11
31periapical granuloma10.0TNFSF11, IL2RA
32hyperparathyroidism10.0TNFSF11, TNFRSF11B
33cholesteatoma10.0TNFRSF11B, TNFSF11
34viral hepatitis10.0FAS
35psoriasis10.0PTPN22, IL2RA
36aortic valve stenosis10.0TNFRSF11B, TNFSF11
37common variable immune deficiency10.0IL2RB, IL2RA
38vitiligo10.0PTPN22
39posterior uveitis10.0IL2RA, IL2RB
40sarcoidosis10.0IL2RB, IL2RA
41beta thalassemia10.0TNFRSF11B, TNFSF11
42polyostotic osteolytic dysplasia, hereditary expansile10.0TNFRSF11A, TNFSF11, TNFRSF11B
43paget disease, juvenile10.0TNFRSF11B, TNFSF11, TNFRSF11A
44mycosis fungoides10.0IL2RB, IL2RA
45hypersensitivity reaction type ii disease10.0IL2RA, PTPN22
46osteoarthritis10.0TNFRSF11B, TNFRSF11A, TNFSF11
47hypercalcemia10.0TNFSF11, TNFRSF11A, TNFRSF11B
48osteoporosis, postmenopausal10.0TNFRSF11A, TNFRSF11B, TNFSF11
49tropical spastic paraparesis10.0IL2RB, IL2RA
50vogt-koyanagi-harada disease10.0IL2RA, FAS

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to polyarticular onset juvenile idiopathic arthritis

Clinical Features for Polyarticular Onset Juvenile Idiopathic Arthritis

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 9)
  • joint/articular deformation
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • micrognathia/retrognathia/micrognathism/retrognathism
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Polyarticular Onset Juvenile Idiopathic Arthritis

Drug clinical trials:

Search ClinicalTrials for Polyarticular Onset Juvenile Idiopathic Arthritis

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Search CenterWatch for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

Animal Models for Polyarticular Onset Juvenile Idiopathic Arthritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

Sources:
51PubMed
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Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Childhood arthritis and rheumatology research alliance consensus treatment plans for new onset polyarticular juvenile idiopathic arthritis. (24339215)
2013
2
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? (18802807)
2008

Genetic Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

Expression for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

Sources:
54Reactome, 4Cell Signaling Technology, 53R&D Systems, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 52QIAGEN, 56SinoBiological
See all sources

Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5IL2RB, IL2RA, TYK2
29.5TYK2, IL2RA, IL2RB
3
Hide members
9.5TYK2, IL2RA, IL2RB
49.4IL2RA, CD247, STAT4
59.4IL2RA, TYK2, STAT4
6
Hide members
9.4FAS, IL2RA, IL2RB
7
Hide members
9.2PTPN2, IL2RB, IL2RA, TYK2
89.1TNFRSF11B, TNFSF11
99.1IL2RB, IL2RA, CD247, STAT4
109.1STAT4, TYK2, IL2RA, IL2RB
119.1STAT4, TYK2, IL2RA, IL2RB
12
Hide members
9.1IL2RB, IL2RA, TYK2, STAT4
13
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9.0FAS, TYK2, IL2RA, IL2RB
148.8FAS, TNFSF11, TNFRSF11A
158.8FAS, TNFSF11, TNFRSF11A
16
Hide members
8.7IL2RB, IL2RA, CD247, TYK2, STAT4
17
Hide members
8.6TNFRSF11A, TNFSF11, STAT4, IL2RB
188.5TNFSF11, FAS, IL2RA, IL2RB, PTPN22
19
Hide members
8.5TNFRSF11B, TNFSF11, TNFRSF11A
208.5TNFRSF11B, TNFSF11, TNFRSF11A
21
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
8.5TNFRSF11B, TNFSF11, TNFRSF11A
22
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8.5TNFRSF11A, TNFSF11, TNFRSF11B
23
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8.3TNFRSF11A, TNFSF11, STAT4, IL2RA, IL2RB
24
Hide members
8.2TNFRSF11A, TNFSF11, IL2RA, IL2RB, PTPN22, PTPN2
258.1TNFRSF11A, TNFSF11, TNFRSF11B, TYK2
26
Hide members
8.0TNFRSF11A, TNFSF11, TNFRSF11B, FAS
27
Hide members
7.6TNFRSF11A, TNFSF11, TNFRSF11B, FAS, CD247
28
Hide members
7.0TNFRSF11A, TNFSF11, TNFRSF11B, FAS, TYK2, IL2RA

Compounds for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1lentinan4510.3IL2RB, IL2RA
2mycophenolate4510.3IL2RB, IL2RA
3thymoglobulin4510.2IL2RB, IL2RA
4denileukin diftitox45 50 1112.2IL2RA, IL2RB
5Aldesleukin1110.1IL2RB, IL2RA
6daclizumab45 1110.9IL2RB, IL2RA
7rantes459.8FAS, IL2RA, IL2RB
8delta9-tetrahydrocannabinol459.8IL2RB, IL2RA
9okt3459.8IL2RB, IL2RA, FAS
10ivig459.7FAS, IL2RA, IL2RB
11hcc-1459.5TNFRSF11B, TNFSF11
12ifn-alpha459.4FAS, IL2RB, TYK2, IL2RA
13phosphotyrosine459.4IL2RB, TYK2, PTPN2, STAT4
14teriparatide45 1110.3TNFSF11, TNFRSF11B
15laccer459.3TNFRSF11A, TNFSF11
16melatonin45 60 29 11 2413.3IL2RB, IL2RA, TNFRSF11B
1725-hydroxyvitamin d459.2TNFRSF11B, IL2RA, TNFSF11
18ibandronate45 1110.2TNFRSF11B, TNFSF11
19etanercept45 50 1111.2TNFSF11, TNFRSF11B, IL2RB
20n acetylcysteine459.2TNFSF11, IL2RB, FAS, IL2RA
21rapamycin459.1IL2RB, TNFSF11, IL2RA, FAS
22dexamethasone45 50 29 1112.1TNFSF11, TNFRSF11B, FAS
233-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.0FAS, TNFRSF11B, TNFSF11
24azathioprine45 50 2 1112.0TNFRSF11B, TNFSF11, IL2RA, IL2RB
25prednisolone45 29 1111.0TNFRSF11B, FAS, IL2RB, IL2RA
26denosumab45 1110.0TNFSF11, TNFRSF11A, TNFRSF11B
27polyethylene458.9TNFRSF11A, TNFRSF11B, TNFSF11
28aspirin45 50 29 2411.9IL2RB, FAS, IL2RA, TNFRSF11B
29methotrexate45 50 1110.9IL2RB, TNFSF11, TNFRSF11B, IL2RA
30raloxifene45 29 50 1111.9TNFSF11, TNFRSF11B, TNFRSF11A
31arginine458.9FAS, PTPN2, CD247, PTPN22, IL2RB, IL2RA
32vitamin k2458.8TNFRSF11B, TNFSF11
33hydroxyapatite458.8TNFRSF11B, TNFSF11, TNFRSF11A
34creatinine458.7IL2RB, TNFRSF11B, TNFSF11, FAS
35ascorbic acid45 249.6FAS, TNFSF11, TNFRSF11B, IL2RA
36serine458.6TNFRSF11A, IL2RB, TNFRSF11B, TNFSF11
371,25 dihydroxy vitamin d3458.6IL2RB, TNFRSF11B, TNFSF11, TNFRSF11A
38vitamin d458.6TNFSF11, FAS, TNFRSF11B, IL2RA
39calcitriol45 60 11 2411.6IL2RA, TNFRSF11B, TNFSF11, TNFRSF11A
40doxorubicin45 50 1110.5IL2RA, TNFSF11, TNFRSF11B, FAS
41infliximab45 50 1110.5TNFRSF11B, IL2RB, IL2RA, FAS, TNFSF11
42genistein45 29 60 2 11 2413.4IL2RB, TNFSF11, TNFRSF11B, IL2RA, FAS
43cyclosporin a45 29 6010.4TNFRSF11B, IL2RB, FAS, IL2RA, TNFSF11
44ly294002458.4FAS, TNFRSF11B, TNFSF11, TYK2
45pge2458.3TNFSF11, IL2RB, TNFRSF11A, TNFRSF11B, IL2RA
46vegf457.8TNFRSF11B, IL2RB, IL2RA, TNFRSF11A, TNFSF11, FAS
47gp 130457.8TNFSF11, TNFRSF11A, FAS, IL2RA, TYK2, TNFRSF11B
48nitric oxide45 11 249.7TNFRSF11A, TNFSF11, TNFRSF11B, IL2RB, FAS
49phosphatidylinositol456.7TNFRSF11A, TNFSF11, FAS, STAT4, TYK2, CD247
50tyrosine456.1STAT4, TNFSF11, TNFRSF11B, FAS, TYK2, CD247

GO Terms for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7IL2RB, IL2RA, FAS, TNFRSF11A

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of T cell receptor signaling pathwayGO:05086010.0PTPN2, PTPN22
2activation-induced cell death of T cellsGO:0069249.8FAS, IL2RA
3T cell differentiationGO:0302179.6PTPN2, PTPN22
4positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:0718489.6TNFRSF11A, TNFSF11
5TNFSF11-mediated signaling pathwayGO:0718479.5TNFRSF11A, TNFSF11
6positive regulation of fever generation by positive regulation of prostaglandin secretionGO:0718129.5TNFRSF11A, TNFSF11
7mammary gland alveolus developmentGO:0607499.4TNFSF11, TNFRSF11A
8monocyte chemotaxisGO:0025489.3TNFRSF11A, TNFSF11
9tumor necrosis factor-mediated signaling pathwayGO:0332099.3TNFSF11, TNFRSF11A
10osteoclast differentiationGO:0303169.2TNFSF11, TNFRSF11A
11cytokine-mediated signaling pathwayGO:0192218.8PTPN2, IL2RB, TYK2, STAT4, TNFSF11

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:0049119.9IL2RB, IL2RA
2interleukin-2 bindingGO:0199769.8IL2RB, IL2RA
3transmembrane signaling receptor activityGO:0048888.7TNFRSF11A, FAS, CD247
4receptor activityGO:0048728.5FAS, TNFRSF11B, TNFRSF11A

Products for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet