MCID: PLY065
MIFTS: 30

Polyarticular Onset Juvenile Idiopathic Arthritis

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Polyarticular Onset Juvenile Idiopathic Arthritis:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 49
Polyarticular Juvenile Rheumatoid Arthritis 49 69
Juvenile Polyarthritis Rheumatoid Factor Negative 49
Juvenile Polyarthritis Rheumatoid Factor Positive 49
Juvenile Chronic Polyarthritis 69

Classifications:



External Ids:

UMLS 69 C0311221

Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards based summary : Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to rheumatoid arthritis and arthritis. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is TNFRSF11A (TNF Receptor Superfamily Member 11a), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Development Endothelin-1/EDNRA signaling. The drugs Methotrexate and Sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are craniofacial and limbs/digits/tail

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.9 TNFRSF11A TNFRSF11B TNFSF11
2 arthritis 29.3 TNFRSF11A TNFSF11
3 juvenile rheumatoid arthritis 11.8
4 breast leiomyosarcoma 10.0 TNFRSF11A TNFSF11
5 aneurysmal bone cysts 10.0 TNFRSF11A TNFSF11
6 bone cancer 9.9 TNFRSF11A TNFSF11
7 multicentric reticulohistiocytosis 9.9 TNFRSF11B TNFSF11
8 kummell's disease 9.9 TNFRSF11B TNFSF11
9 periodontitis, chronic 9.9 TNFRSF11B TNFSF11
10 chronic apical periodontitis 9.8 TNFRSF11B TNFSF11
11 osteopetrosis 9.8 TNFRSF11A TNFSF11
12 glucocorticoid-induced osteoporosis 9.8 TNFRSF11B TNFSF11
13 endosteal hyperostosis, autosomal dominant 9.8 TNFRSF11B TNFSF11
14 osteonecrosis 9.8 TNFRSF11B TNFSF11
15 spondyloarthropathy 1 9.8 TNFRSF11B TNFSF11
16 cholesteatoma 9.8 TNFRSF11B TNFSF11
17 bone inflammation disease 9.8 TNFRSF11B TNFSF11
18 periostitis 9.8 TNFRSF11A TNFRSF11B
19 aortic valve disease 2 9.8 TNFRSF11B TNFSF11
20 synovitis 9.7 TNFRSF11B TNFSF11
21 periodontitis 9.7 TNFRSF11B TNFSF11
22 arthropathy 9.7 TNFRSF11B TNFSF11
23 myeloma, multiple 9.7 TNFRSF11B TNFSF11
24 psoriatic arthritis 9.6 TNFRSF11B TNFSF11
25 osteogenic sarcoma 9.6 TNFRSF11B TNFSF11
26 osteoarthritis 9.5 TNFRSF11B TNFSF11
27 hemophilic arthropathy 9.4 TNFRSF11A TNFRSF11B TNFSF11
28 paget disease of bone 5, juvenile-onset 9.4 TNFRSF11A TNFRSF11B TNFSF11
29 familial expansile osteolysis 9.4 TNFRSF11A TNFRSF11B TNFSF11
30 cohen-gibson syndrome 9.4 TNFRSF11A TNFRSF11B TNFSF11
31 multicentric carpotarsal osteolysis syndrome 9.4 TNFRSF11A TNFRSF11B TNFSF11
32 periapical periodontitis 9.4 TNFRSF11A TNFRSF11B TNFSF11
33 tooth resorption 9.4 TNFRSF11A TNFRSF11B TNFSF11
34 ischemic bone disease 9.4 TNFRSF11A TNFRSF11B TNFSF11
35 root resorption 9.4 TNFRSF11A TNFRSF11B TNFSF11
36 bone resorption disease 9.4 TNFRSF11A TNFRSF11B TNFSF11
37 bone remodeling disease 9.4 TNFRSF11A TNFRSF11B TNFSF11
38 giant cell tumor 9.4 TNFRSF11A TNFRSF11B TNFSF11
39 paget's disease of bone 9.4 TNFRSF11A TNFRSF11B TNFSF11
40 periodontal disease 9.4 TNFRSF11A TNFRSF11B TNFSF11
41 osteoporosis 9.4 TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Polyarticular Onset Juvenile Idiopathic Arthritis

MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.13 TNFRSF11A TNFRSF11B TNFSF11
2 limbs/digits/tail MP:0005371 8.8 TNFRSF11A TNFRSF11B TNFSF11

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

Drugs for Polyarticular Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
2
Sulfasalazine Approved Phase 3 599-79-1 5359476 5353980
3
Adalimumab Approved Phase 3 331731-18-1 16219006
4
Etanercept Approved, Investigational Phase 3 185243-69-0
5
Infliximab Approved Phase 3 170277-31-3
6
Hydroxychloroquine Approved Phase 3 118-42-3 3652
7
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
8
Naltrexone Approved, Investigational, Vet_approved Phase 3 16590-41-3 5360515
9
Abatacept Approved Phase 3 332348-12-6 10237
10
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
11
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
12
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
14 tannic acid Approved, Nutraceutical Phase 3
15 Prednisolone acetate Phase 3
16 Analgesics Phase 3
17 Methylprednisolone acetate Phase 3
18 Methylprednisolone Hemisuccinate Phase 3
19 Folic Acid Antagonists Phase 3
20 Narcotic Antagonists Phase 3
21 Narcotics Phase 3
22 Gastrointestinal Agents Phase 3
23 Analgesics, Non-Narcotic Phase 3
24 Nucleic Acid Synthesis Inhibitors Phase 3
25 Dermatologic Agents Phase 3
26 Vitamin B Complex Phase 3
27 Peripheral Nervous System Agents Phase 3
28 Antibodies, Monoclonal Phase 3
29 Pharmaceutical Solutions Phase 3
30 Immunoglobulins Phase 3
31 Prednisolone hemisuccinate Phase 3
32 Immunosuppressive Agents Phase 3
33 Prednisolone phosphate Phase 3
34 Antimetabolites Phase 3
35 Anti-Inflammatory Agents Phase 3
36 Antimetabolites, Antineoplastic Phase 3
37 Anti-Inflammatory Agents, Non-Steroidal Phase 3
38 Antibodies Phase 3
39 Antirheumatic Agents Phase 3
40 Rheumatoid Factor Phase 3
41 Folate Nutraceutical Phase 3
42 Vitamin B9 Nutraceutical Phase 3

Interventional clinical trials:

(show all 21)

# Name Status NCT ID Phase Drugs
1 Determining Predictors of Safe Discontinuation of Anti-TNF Treatment in JIA Completed NCT00792233 Phase 4
2 Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid Arthritis Completed NCT00690573 Phase 3
3 BMS-188667 in Children and Adolescents With Juvenile Rheumatoid Arthritis Completed NCT00095173 Phase 3 Abatacept;Placebo;Abatacept
4 A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Juvenile Rheumatoid Arthritis Completed NCT00036374 Phase 3 Infliximab
5 Study of Human Anti-TNF Monoclonal Antibody Adalimumab in Children With Polyarticular Juvenile Idiopathic Arthritis (JIA) Completed NCT00048542 Phase 3 OLE BSA Adalimumab +/- MTX;OLE FD Adalimumab +/- MTX
6 Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis Completed NCT01015547 Phase 3 Infliximab plus methotrexate;Combination of DMARDs;Methotrexate alone
7 Long-term Treatment Study of MRA for Polyarticular Juvenile Idiopathic Arthritis (pJIA) Completed NCT00144625 Phase 3 MRA(Tocilizumab)
8 Study of MRA for Polyarticular Juvenile Idiopathic Arthritis (pJIA) Completed NCT00144664 Phase 3 MRA(Tocilizumab)
9 A Study of Tocilizumab in Patients With Active Polyarticular Juvenile Idiopathic Arthritis Completed NCT00988221 Phase 3 Tocilizumab;Placebo
10 An Extension Long-Term Study of RoActemra/Actemra (Tocilizumab) in Patients With Polyarticular Juvenile Idiopathic Arthritis Who Completed The WA19977 Study Completed NCT01727986 Phase 3 tocilizumab [RoActemra/Actemra]
11 Active Juvenile Idiopathic Arthritis (JIA) Compassionate Use Completed NCT00775437 Phase 3 Adalimumab
12 Treatment Tapering in JIA With Inactive Disease Recruiting NCT02840175 Phase 3 etanercept;adalimumab;Abatacept;Tocilizumab
13 Pharmacokinetics, Efficacy and Safety of Abatacept Administered Subcutaneously (SC) in Children and Adolescents With Active Polyarticular Juvenile Idiopathic Arthritis (pJIA) and Inadequate Response (IR) to Biologic or Non Biologic Disease Modifying Anti- Active, not recruiting NCT01844518 Phase 3
14 A Study of the Safety and Efficacy of CNTO 148 (Golimumab) in Children With Juvenile Idiopathic Arthritis (JIA) and Multiple Joint Involvement Who Have Poor Response to Methotrexate (GO KIDS) Terminated NCT01230827 Phase 3 CNTO 148 (Golimumab);Placebo;Methotrexate
15 A Study of Subcutaneously (SC) Administered Tocilizumab (TCZ) in Participants With Polyarticular-Course Juvenile Idiopathic Arthritis (pJIA) Completed NCT01904279 Phase 1 Tocilizumab
16 Ultrasonography in Juvenile Idiopathic Arthritis Completed NCT01304420 Early Phase 1
17 Surveillance of Humira in Korean JIA Patients Completed NCT02141984
18 Enbrel-Juvenile Idiopathic Arthritis (JIA) Use Results Survey [All-Case Surveillance] Completed NCT01145352 Etanercept (genetical recombination)
19 Start Time Optimization of Biologics in Polyarticular JIA Recruiting NCT02593006
20 Juvenile Idiopathic Arthritis (JIA) Registry Active, not recruiting NCT00783510 Methotrexate
21 Request for Single Patient IND for Compassionate/Emergency Use of Tocilizumab No longer available NCT00862758 Tocilizumab

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

38
Bone

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

# Title Authors Year
1
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? ( 18802807 )
2008

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

Expression for Polyarticular Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for Polyarticular Onset Juvenile Idiopathic Arthritis

Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 TNFRSF11A TNFRSF11B TNFSF11
2
Show member pathways
12.16 TNFRSF11A TNFRSF11B TNFSF11
3
Show member pathways
12.14 TNFRSF11A TNFRSF11B TNFSF11
4
Show member pathways
12 TNFRSF11A TNFSF11
5
Show member pathways
11.9 TNFRSF11A TNFRSF11B TNFSF11
6
Show member pathways
11.79 TNFRSF11A TNFSF11
7 11.79 TNFRSF11A TNFSF11
8 11.54 TNFRSF11A TNFRSF11B TNFSF11
9 11.47 TNFRSF11A TNFSF11
10 11.43 TNFRSF11A TNFSF11
11
Show member pathways
11.32 TNFRSF11A TNFSF11
12
Show member pathways
11.25 TNFRSF11A TNFRSF11B TNFSF11
13 10.79 TNFRSF11A TNFRSF11B TNFSF11
14 10.51 TNFRSF11B TNFSF11
15 10 TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Polyarticular Onset Juvenile Idiopathic Arthritis

Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.8 TNFRSF11A TNFRSF11B TNFSF11

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.51 TNFRSF11A TNFRSF11B
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.49 TNFRSF11A TNFSF11
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.48 TNFRSF11A TNFSF11
4 ossification GO:0001503 9.46 TNFRSF11A TNFSF11
5 apoptotic signaling pathway GO:0097190 9.43 TNFRSF11A TNFRSF11B
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 TNFRSF11A TNFRSF11B TNFSF11
7 monocyte chemotaxis GO:0002548 9.4 TNFRSF11A TNFSF11
8 osteoclast differentiation GO:0030316 9.37 TNFRSF11A TNFSF11
9 mammary gland alveolus development GO:0060749 9.32 TNFRSF11A TNFSF11
10 TNFSF11-mediated signaling pathway GO:0071847 9.16 TNFRSF11A TNFSF11
11 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFRSF11A TNFSF11
12 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.62 TNFRSF11A TNFSF11

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.16 TNFRSF11A TNFRSF11B
2 cytokine activity GO:0005125 8.96 TNFRSF11B TNFSF11
3 tumor necrosis factor-activated receptor activity GO:0005031 8.62 TNFRSF11A TNFRSF11B

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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