MCID: PLY065
MIFTS: 32

Polyarticular Onset Juvenile Idiopathic Arthritis malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Aliases & Descriptions for Polyarticular Onset Juvenile Idiopathic Arthritis:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 48
Polyarticular Juvenile Rheumatoid Arthritis 48 68
Juvenile Polyarthritis Rheumatoid Factor Negative 48
 
Juvenile Polyarthritis Rheumatoid Factor Positive 48
Juvenile Chronic Polyarthritis 68

Classifications:



Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards based summary: Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to rheumatoid arthritis and rheumatoid arthritis, systemic juvenile. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is TNFRSF11A (TNF Receptor Superfamily Member 11a), and among its related pathways are Osteoblast Signaling and RANK Signaling in Osteoclasts. Affiliated tissues include bone, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

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Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis29.9IL2RA, IL2RB, PTPN22, STAT4, TNFRSF11A, TNFRSF11B
2rheumatoid arthritis, systemic juvenile11.3
3extrahepatic bile duct leiomyosarcoma10.3TNFRSF11A, TNFSF11
4cortical blindness10.2TNFRSF11B, TNFSF11
5peripheral scars of retina10.2TNFRSF11B, TNFSF11
6cocaine dependence10.2TNFRSF11A, TNFRSF11B
7phka2-related phosphorylase kinase deficiency10.2TNFRSF11A, TNFRSF11B, TNFSF11
8birk-barel mental retardation dysmorphism syndrome10.2TNFRSF11A, TNFRSF11B, TNFSF11
9osteopetrosis, autosomal recessive 710.2TNFRSF11A, TNFRSF11B, TNFSF11
10hepatic fibrosis renal cysts mental retardation10.2TNFRSF11A, TNFRSF11B, TNFSF11
11epilepsy, idiopathic generalized 1410.2TNFRSF11A, TNFRSF11B, TNFSF11
12microcephaly 10, primary, autosomal recessive10.2TNFRSF11A, TNFRSF11B, TNFSF11
13maroteaux stanescu cousin syndrome10.2TNFRSF11A, TNFRSF11B, TNFSF11
14bronchus cancer10.2TNFRSF11A, TNFRSF11B, TNFSF11
15bulbomembranous urethral cancer10.2TNFRSF11A, TNFRSF11B, TNFSF11
16glossitis10.2TNFRSF11A, TNFRSF11B, TNFSF11
17chromosomal disease10.2TNFRSF11A, TNFRSF11B, TNFSF11
18dysbaric osteonecrosis10.2TNFRSF11A, TNFRSF11B, TNFSF11
19ischemic bone disease10.2TNFRSF11A, TNFRSF11B, TNFSF11
20preretinal fibrosis10.2TNFRSF11A, TNFRSF11B, TNFSF11
21intrahepatic cholestasis10.2TNFRSF11A, TNFRSF11B, TNFSF11
22bladder papillary transitional cell neoplasm10.1TNFRSF11A, TNFRSF11B, TNFSF11
23histiocytosis10.1TNFRSF11A, TNFRSF11B, TNFSF11
24bone angioendothelial sarcoma10.1PTPN22, TNFRSF11B, TNFSF11
25molybdenum cofactor deficiency a10.1PTPN22, TNFRSF11B, TNFSF11
26aortic coarctation10.1IL2RA, PTPN22
27x-linked dominant intellectual disability-epilepsy syndrome10.1PTPN22, STAT4
28chromosome 16q22 deletion syndrome10.0TNFRSF11A, TNFSF11
29anterior corneal pigmentation10.0FAS, IL2RA, PTPN22
30prostatic urethral cancer10.0FAS, IL2RA, PTPN22
31macrogyria, pseudobulbar palsy and mental retardation10.0FAS, TYK2
32diabetes mellitus, insulin-dependent, 1210.0FAS, IL2RA, PTPN22
33articulation disorder10.0FAS, PTPN22, STAT4
34arthritis9.9
35goodpasture syndrome9.9FAS, IL2RA, STAT4
36intracranial hemorrhage in brain cerebrovascular malformations9.8IL2RA, IL2RB, PTPN22
37cousin syndrome9.7CD247, IL2RA, PTPN22, STAT4
38hereditary ataxia9.6FAS, IL2RA, IL2RB, TYK2
39t-cell prolymphocytic leukemia8.8ANKRD55, CD247, FAS, IL2RA, IL2RB, PTPN2
40non-amyloid monoclonal immunoglobulin deposition disease8.8ANKRD55, CD247, FAS, IL2RA, IL2RB, PTPN2
41polyomavirus allograft nephropathy8.5ANKRD55, CD247, FAS, IL2RA, IL2RB, PTPN2

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to polyarticular onset juvenile idiopathic arthritis

Symptoms & Phenotypes for Polyarticular Onset Juvenile Idiopathic Arthritis

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MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.6FAS, PTPN2, TNFRSF11A, TNFRSF11B, TNFSF11
2MP:00053797.5CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22
3MP:00053787.4FAS, IL2RA, IL2RB, PTPN2, PTPN22, TNFRSF11A
4MP:00053976.6CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22
5MP:00053876.5CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22
6MP:00107685.8CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

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Drugs for Polyarticular Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
InfliximabapprovedPhase 3392170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
2
MethotrexateapprovedPhase 315511959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
3
AdalimumabapprovedPhase 3494331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
4
AbataceptapprovedPhase 3197332348-12-610237
Synonyms:
CTLA4-Ig
 
CTLA4-IgG4m
CTLA4Ig
CTLA4IgG4m
5
Etanerceptapproved, investigationalPhase 3403185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
6
Folic Acidapproved, nutraceutical, vet_approvedPhase 3439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
7
leucovorinapproved, NutraceuticalPhase 3323558-05-954575, 6560146, 143
Synonyms:
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolate
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-Formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
5-formyltetrahydrofolic acid
Acide folinique
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinate
Folinic acid
Folinic acid calcium salt
 
Folinic acid calcium salt USP27
Folinic acid-SF
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
L-Leucovorin
L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
L-leucovorin
Leucal
Leucovorin calcium
Leucovorin folinic acid
Leucovorinum
Leukovorin
Levoleucovorin
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyl-THF
N5-Formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Welcovorin
Wellcovorin
folinate
8Nucleic Acid Synthesis InhibitorsPhase 34962
9Pharmaceutical SolutionsPhase 38192
10Vitamin B ComplexPhase 34337
11Gastrointestinal AgentsPhase 38402
12Immunosuppressive AgentsPhase 313086
13AntibodiesPhase 36394
14Folic Acid AntagonistsPhase 32257
15Anti-Inflammatory AgentsPhase 310729
16Antibodies, MonoclonalPhase 34039
17ImmunoglobulinsPhase 36394
18Antirheumatic AgentsPhase 310956
19AntimetabolitesPhase 312054
20Dermatologic AgentsPhase 35806
21Antimetabolites, AntineoplasticPhase 37361
22Anti-Inflammatory Agents, Non-SteroidalPhase 34443
23Analgesics, Non-NarcoticPhase 36501
24Peripheral Nervous System AgentsPhase 323689
25AnalgesicsPhase 311733
26Vitamin B9NutraceuticalPhase 34392
27FolateNutraceuticalPhase 34392

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid ArthritisCompletedNCT00690573Phase 3
2A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Juvenile Rheumatoid ArthritisCompletedNCT00036374Phase 3
3BMS-188667 in Children and Adolescents With Juvenile Rheumatoid ArthritisCompletedNCT00095173Phase 3
4Study of Human Anti-TNF Monoclonal Antibody Adalimumab in Children With Polyarticular Juvenile Idiopathic Arthritis (JIA)CompletedNCT00048542Phase 3
5A Study to Evaluate the Pharmacokinetics, Efficacy and Safety of Intravenous Golimumab in Pediatric Participants With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate TherapyRecruitingNCT02277444Phase 3
6Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid ArthritisTerminatedNCT00078806Phase 3
7Ultrasonography in Juvenile Idiopathic ArthritisCompletedNCT01304420Early Phase 1
8Start Time Optimization of Biologics in Polyarticular JIARecruitingNCT02593006

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

36
Bone

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? (18802807)
2008

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathwaysScoreTop Affiliating Genes
19.9TNFRSF11B, TNFSF11
2
Show member pathways
9.6TNFRSF11A, TNFRSF11B, TNFSF11
39.6TNFRSF11A, TNFRSF11B, TNFSF11
49.6TNFRSF11A, TNFRSF11B, TNFSF11
5
Show member pathways
9.5STAT4, TYK2
69.5FAS, TNFRSF11A, TNFSF11
79.2IL2RA, IL2RB
89.2CD247, IL2RA, STAT4
99.2PTPN2, STAT4, TYK2
10
Show member pathways
9.2FAS, TNFRSF11A, TNFRSF11B, TNFSF11
11
Show member pathways
9.2FAS, TNFRSF11A, TNFRSF11B, TNFSF11
12
Show member pathways
9.1IL2RA, STAT4, TYK2
139.0TNFRSF11A, TNFRSF11B, TNFSF11, TYK2
148.9IL2RA, IL2RB, STAT4
15
Show member pathways
8.9IL2RA, IL2RB, STAT4
16
Show member pathways
8.8FAS, IL2RA, IL2RB
17
Show member pathways
8.4CD247, IL2RA, IL2RB, STAT4
188.3IL2RA, IL2RB, STAT4, TYK2
19
Show member pathways
8.2FAS, IL2RA, IL2RB, TYK2
20
Show member pathways
8.0IL2RA, IL2RB, PTPN2, STAT4, TYK2
21
Show member pathways
7.8CD247, IL2RA, IL2RB, STAT4, TYK2
22
Show member pathways
7.8CD247, IL2RA, IL2RB, STAT4, TYK2
23
Show member pathways
7.5FAS, IL2RA, IL2RB, PTPN2, PTPN22, TNFRSF11A
24
Show member pathways
7.4IL2RA, IL2RB, PTPN2, TNFRSF11A, TNFRSF11B, TNFSF11
25
Show member pathways
7.4CD247, FAS, IL2RA, IL2RB, STAT4, TNFRSF11A
26
Show member pathways
6.8CD247, FAS, IL2RA, IL2RB, TNFRSF11A, TNFRSF11B
276.6FAS, IL2RA, IL2RB, PTPN2, PTPN22, STAT4
28
Show member pathways
6.5CD247, IL2RA, IL2RB, PTPN2, PTPN22, TNFRSF11A

GO Terms for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.5FAS, IL2RA, IL2RB, TNFRSF11A

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1mammary gland alveolus developmentGO:006074910.6TNFRSF11A, TNFSF11
2osteoclast differentiationGO:003031610.6TNFRSF11A, TNFSF11
3positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:007184810.6TNFRSF11A, TNFSF11
4positive regulation of fever generation by positive regulation of prostaglandin secretionGO:007181210.6TNFRSF11A, TNFSF11
5TNFSF11-mediated signaling pathwayGO:007184710.5TNFRSF11A, TNFSF11
6negative regulation of T cell receptor signaling pathwayGO:005086010.4PTPN2, PTPN22
7activation-induced cell death of T cellsGO:000692410.3FAS, IL2RA
8T cell differentiationGO:003021710.3PTPN2, PTPN22
9apoptotic signaling pathwayGO:009719010.2FAS, TNFRSF11A, TNFRSF11B
10T cell homeostasisGO:004302910.2FAS, IL2RA
11interleukin-2-mediated signaling pathwayGO:00381109.9IL2RA, IL2RB
12cytokine-mediated signaling pathwayGO:00192219.8IL2RB, STAT4, TNFSF11
13immune responseGO:00069559.7FAS, IL2RA, TNFRSF11B, TNFSF11
14inflammatory responseGO:00069549.7FAS, IL2RA, TNFRSF11A, TNFRSF11B
15response to lipopolysaccharideGO:00324969.7FAS, PTPN22, TNFRSF11A, TNFRSF11B
16tumor necrosis factor-mediated signaling pathwayGO:00332099.2FAS, TNFRSF11A, TNFRSF11B, TNFSF11

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase bindingGO:19907829.9CD247, PTPN22
2interleukin-2 bindingGO:00199769.7IL2RA, IL2RB
3interleukin-2 receptor activityGO:00049119.7IL2RA, IL2RB
4tumor necrosis factor-activated receptor activityGO:00050319.5FAS, TNFRSF11A, TNFRSF11B

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet