MCID: PLY065
MIFTS: 45

Polyarticular Onset Juvenile Idiopathic Arthritis malady

Rare diseases, Eye diseases, Respiratory diseases, Bone diseases categories

Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards: Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to juvenile rheumatoid arthritis and rheumatoid arthritis, and has symptoms including biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp, biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp and autoimmunity/autoimmune reaction/autoantibodies. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is CD247 (CD247 molecule), and among its related pathways are IL2-mediated signaling events and IL2 signaling events mediated by PI3K. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include bone and eye, and related mouse phenotypes are digestive/alimentary and cellular.

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

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44NIH Rare Diseases, 63UMLS, 50Orphanet, 27ICD10 via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

50
juvenile rheumatoid factor-negative polyarthritis:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000; Age of death: Normal
juvenile rheumatoid factor-positive polyarthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

polyarticular onset juvenile idiopathic arthritis 44
polyarticular juvenile rheumatoid arthritis 44 63
juvenile polyarthritis rheumatoid factor negative 44
juvenile polyarthritis rheumatoid factor positive 44
juvenile rheumatoid factor-negative polyarthritis 50
juvenile rheumatoid factor-positive polyarthritis 50
polyarthritis without rheumatoid factor 50
polyarthritis with rheumatoid factor 50


External Ids:

ICD10 via Orphanet27 M08.3, M08.0
ICD1026 M13.0

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

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18GeneCards, 19GeneDecks
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Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile rheumatoid arthritis31.6IL2RA, IL2RB
2rheumatoid arthritis31.2IL2RA, IL2RB, TYK2, STAT4, PTPN22, FAS
3arthritis30.7PTPN22, IL2RB
4systemic lupus erythematosus30.3IL2RB, CD247, IL2RA, TYK2, PTPN22, FAS
5juvenile rheumatoid factor-negative polyarthritis without anti-nuclear antibodies10.5
6juvenile rheumatoid factor-negative polyarthritis with anti-nuclear antibodies10.5
7aortic valve insufficiency10.4
8lupus erythematosus10.4
9mannose-binding lectin deficiency10.4
10endotheliitis10.4
11uveitis10.1IL2RA
12posterior uveitis10.1IL2RB, IL2RA
13thyroiditis10.1PTPN22
14tropical spastic paraparesis10.1IL2RA, IL2RB
15immunodeficiency, common variable, 710.1IL2RB, IL2RA
16extrinsic allergic alveolitis10.1IL2RA, IL2RB
17acute graft versus host disease10.1IL2RB, IL2RA
18gamma chain deficiency10.1IL2RB, IL2RA
19congenital stationary night blindness, type 1f10.1IL2RA, IL2RB
20common variable immune deficiency10.1IL2RB, IL2RA
21hairy cell leukemia10.1IL2RA, IL2RB
22pulmonary sarcoidosis10.1IL2RB, IL2RA
23vogt-koyanagi-harada disease10.1FAS, IL2RA
24peripheral t-cell lymphoma10.1IL2RA, IL2RB
25pulmonary tuberculosis10.1IL2RA, CD247
26autoimmune lymphoproliferative syndrome10.1FAS, IL2RA
27mycosis fungoides10.1IL2RB, IL2RA
28anaplastic large cell lymphoma10.0IL2RB, IL2RA
29splenomegaly10.0IL2RA, FAS
30diphtheria10.0IL2RA, IL2RB
31hodgkin's lymphoma10.0CD247, IL2RA, IL2RB
32sezary's disease10.0IL2RA, IL2RB, STAT4
33hepatitis10.0IL2RB, FAS
34cutaneous t cell lymphoma10.0IL2RA, FAS, IL2RB
35graft versus host disease10.0IL2RA, IL2RB, FAS
36severe combined immunodeficiency10.0IL2RA, IL2RB, TYK2
37b-cell chronic lymphocytic leukemia10.0FAS, IL2RA, IL2RB
38t-cell leukemia10.0IL2RA, IL2RB, FAS
39non-hodgkin lymphoma10.0IL2RB, FAS, IL2RA
40systemic scleroderma10.0IL2RA, PTPN22, IL2RB
41sjogren's syndrome10.0IL2RA, FAS
42connective tissue disease10.0PTPN22, IL2RA
43hypersensitivity reaction type ii disease10.0PTPN22, IL2RA
44eosinophilia10.0IL2RB, IL2RA
45autoimmune thyroiditis10.0PTPN22, FAS, IL2RA
46graves' disease10.0PTPN22, FAS, IL2RA
47kidney cancer10.0IL2RA, FAS, IL2RB, CD247
48viral infectious disease10.0IL2RA, IL2RB, CD247, FAS
49multiple sclerosis10.0PTPN22, IL2RA, IL2RB, STAT4
50lymphopenia10.0PTPN22, FAS, IL2RB, IL2RA

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to polyarticular onset juvenile idiopathic arthritis

Symptoms for Polyarticular Onset Juvenile Idiopathic Arthritis

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50Orphanet
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Symptoms:

50 (show all 9)
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • autoimmunity/autoimmune reaction/autoantibodies
  • micrognathia/retrognathia/micrognathism/retrognathism
  • hydrarthrosis/articular/joint effusion
  • articular/joint pain/arthralgia
  • restricted joint mobility/joint stiffness/ankylosis
  • arthritis/synovitis/synovial proliferation
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • joint/articular deformation

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Polyarticular Onset Juvenile Idiopathic Arthritis

Drug clinical trials:

Search ClinicalTrials for Polyarticular Onset Juvenile Idiopathic Arthritis

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Search CenterWatch for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

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34MalaCards
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MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

34
Bone, Eye

Animal Models for Polyarticular Onset Juvenile Idiopathic Arthritis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053817.8PTPN2, PTPN22, FAS, IL2RA
2MP:00053847.7CD247, FAS, PTPN22, PTPN2, TYK2
3MP:00053787.2TYK2, PTPN2, PTPN22, FAS, IL2RA, IL2RB
4MP:00053976.7CD247, TYK2, PTPN2, PTPN22, FAS, STAT4
5MP:00053876.6TYK2, PTPN2, PTPN22, FAS, STAT4, IL2RA
6MP:00107686.5TYK2, PTPN2, PTPN22, FAS, STAT4, IL2RA

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

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53PubMed
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Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? (18802807)
2008

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 5Cell Signaling Technology, 55R&D Systems, 54QIAGEN, 56Reactome, 31KEGG
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Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL-2 Signaling pathway39
9.8IL2RB, IL2RA
2
Show member pathways
IL2 signaling events mediated by STAT539
9.8IL2RB, IL2RA
39.8IL2RB, IL2RA
4
Show member pathways
Immune response IL 3 activation and signaling pathway61
9.8IL2RB, IL2RA
59.7STAT4, IL2RA
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.5STAT4, TYK2
79.5TYK2, STAT4
8
Show member pathways
9.5TYK2, STAT4
9
Show member pathways
IL27-mediated signaling events39
9.5STAT4, TYK2
109.4CD247, IL2RA, STAT4
11
Show member pathways
9.3IL2RB, IL2RA, STAT4
12
Show member pathways
9.2FAS, IL2RA, IL2RB
13
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.2IL2RB, IL2RA, TYK2
14
Show member pathways
9.2IL2RB, IL2RA, TYK2
159.2TYK2, IL2RA, IL2RB
16
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.2FAS, STAT4, CD247
179.2IL2RA, STAT4, TYK2
18
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.0STAT4, IL2RA, IL2RB, CD247
19
Show member pathways
8.8TYK2, STAT4, IL2RA, IL2RB
20
Show member pathways
Type III interferon signaling39
8.8TYK2, STAT4, IL2RA, IL2RB
21
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
8.8CD247, FAS, PTPN2
22
Show member pathways
8.7IL2RB, IL2RA, FAS, TYK2
23
Show member pathways
8.7TYK2, FAS, IL2RA, IL2RB
248.6PTPN22, FAS, IL2RA, IL2RB
25
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
8.5TYK2, STAT4, IL2RA, IL2RB, CD247
26
Show member pathways
Immune response IL 12 induced IFN gamma production61
8.5CD247, IL2RB, IL2RA, STAT4, TYK2
27
Show member pathways
8.4TYK2, PTPN2, IL2RA, IL2RB
28
Show member pathways
8.3PTPN2, PTPN22, IL2RA, IL2RB

Compounds for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 3BitterDB, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1lentinan4610.2IL2RB, IL2RA
2mycophenolate4610.2IL2RB, IL2RA
3thymoglobulin4610.2IL2RA, IL2RB
4denileukin diftitox46 52 1212.2IL2RB, IL2RA
5delta9-tetrahydrocannabinol4610.2IL2RB, IL2RA
6daclizumab46 1211.2IL2RB, IL2RA
7basiliximab46 1211.2IL2RA, IL2RB
8alemtuzumab46 1211.2IL2RB, IL2RA
9levamisole46 1211.1IL2RB, IL2RA
10cuprophan4610.1IL2RB, IL2RA
11polysulfone4610.1IL2RB, IL2RA
12mycophenolic acid46 52 1212.1IL2RA, IL2RB
13phorbol 12,13-dibutyrate4610.1IL2RB, IL2RA
14fitc4610.1IL2RA, IL2RB
15con a4610.1IL2RA, IL2RB
162,5-oligoadenylate4610.0IL2RA, IL2RB
17mycophenolate mofetil46 52 1212.0IL2RB, IL2RA
18il 104610.0IL2RB, IL2RA
19erythromycin46 3 52 1213.0IL2RB, IL2RA
20lactose46 1211.0IL2RB, IL2RA
21pentoxifylline46 1210.9IL2RB, IL2RA
222-chlorodeoxyadenosine469.9FAS, IL2RA
23neopterin469.9IL2RB, IL2RA
24okt3469.7FAS, IL2RA, IL2RB
25infliximab46 52 1211.7IL2RB, IL2RA, FAS
26ivig469.7IL2RB, IL2RA, FAS
27prednisolone46 30 1211.7FAS, IL2RA, IL2RB
28ionomycin469.6IL2RB, IL2RA, FAS
29aspirin46 52 30 2512.6IL2RB, IL2RA, FAS
30rantes469.6FAS, IL2RA, IL2RB
31n acetylcysteine469.6IL2RB, IL2RA, FAS
32anisomycin46 1210.6IL2RA, FAS
33polysaccharide469.6IL2RB, IL2RA, FAS
34rapamycin469.5IL2RB, IL2RA, FAS
35genistein46 30 62 3 25 1214.5IL2RB, IL2RA, FAS
36gp 130469.5IL2RA, FAS, TYK2
37cyclosporin a46 30 6211.5FAS, IL2RA, IL2RB
38melatonin46 30 62 25 1213.5IL2RB, IL2RA
39thymidine46 2510.4FAS, IL2RA, IL2RB
40cisplatin46 52 62 1212.3IL2RB, IL2RA, FAS
41creatinine469.2FAS, IL2RA, IL2RB
42dexamethasone46 52 30 1212.2IL2RB, IL2RA, STAT4, FAS
43ifn-alpha469.2TYK2, FAS, IL2RA, IL2RB
44aspartate469.1IL2RB, IL2RA, FAS
45phosphotyrosine468.8TYK2, PTPN2, STAT4, IL2RB
46phosphatidylinositol468.4TYK2, FAS, STAT4, IL2RA, IL2RB, CD247
47serine468.2TYK2, PTPN2, FAS, STAT4, IL2RB
48arginine467.9PTPN2, PTPN22, FAS, IL2RA, IL2RB, CD247
49tyrosine467.0CD247, TYK2, PTPN2, PTPN22, FAS, STAT4

GO Terms for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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17Gene Ontology
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Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2IL2RB, IL2RA, FAS

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation-induced cell death of T cellsGO:0069249.6IL2RA, FAS
2negative regulation of inflammatory responseGO:0507289.3IL2RA, PTPN2
3negative regulation of T cell receptor signaling pathwayGO:0508609.0PTPN2, PTPN22
4T cell differentiationGO:0302178.9PTPN22, PTPN2
5peptidyl-tyrosine dephosphorylationGO:0353358.7PTPN22, PTPN2
6cytokine-mediated signaling pathwayGO:0192218.5IL2RB, STAT4, PTPN2, TYK2

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:0049119.8IL2RB, IL2RA
2interleukin-2 bindingGO:0199769.7IL2RB, IL2RA
3kinase bindingGO:0199009.0FAS, PTPN22
4protein tyrosine phosphatase activityGO:0047259.0PTPN22, PTPN2

Products for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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  • Antibodies
  • Proteins
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Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet