MCID: PLY065
MIFTS: 32

Polyarticular Onset Juvenile Idiopathic Arthritis malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

Aliases & Descriptions for Polyarticular Onset Juvenile Idiopathic Arthritis:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 50
Polyarticular Juvenile Rheumatoid Arthritis 50 69
Juvenile Polyarthritis Rheumatoid Factor Negative 50
Juvenile Polyarthritis Rheumatoid Factor Positive 50
Juvenile Chronic Polyarthritis 69

Classifications:



Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards based summary : Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to rheumatoid arthritis and rheumatoid arthritis, systemic juvenile. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is TNFRSF11A (TNF Receptor Superfamily Member 11a), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Methotrexate and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.9 IL2RA IL2RB PTPN22 STAT4 TNFRSF11A TNFRSF11B
2 rheumatoid arthritis, systemic juvenile 11.3
3 extrahepatic bile duct leiomyosarcoma 10.3 TNFRSF11A TNFSF11
4 cortical blindness 10.2 TNFRSF11B TNFSF11
5 peripheral scars of retina 10.2 TNFRSF11B TNFSF11
6 cocaine dependence 10.2 TNFRSF11A TNFRSF11B
7 phka2-related phosphorylase kinase deficiency 10.2 TNFRSF11A TNFRSF11B TNFSF11
8 birk-barel mental retardation dysmorphism syndrome 10.2 TNFRSF11A TNFRSF11B TNFSF11
9 osteopetrosis, autosomal recessive 7 10.2 TNFRSF11A TNFRSF11B TNFSF11
10 hepatic fibrosis renal cysts mental retardation 10.2 TNFRSF11A TNFRSF11B TNFSF11
11 epilepsy, idiopathic generalized 14 10.2 TNFRSF11A TNFRSF11B TNFSF11
12 microcephaly 10, primary, autosomal recessive 10.2 TNFRSF11A TNFRSF11B TNFSF11
13 maroteaux stanescu cousin syndrome 10.2 TNFRSF11A TNFRSF11B TNFSF11
14 bronchus cancer 10.2 TNFRSF11A TNFRSF11B TNFSF11
15 bulbomembranous urethral cancer 10.2 TNFRSF11A TNFRSF11B TNFSF11
16 glossitis 10.2 TNFRSF11A TNFRSF11B TNFSF11
17 chromosomal disease 10.2 TNFRSF11A TNFRSF11B TNFSF11
18 dysbaric osteonecrosis 10.2 TNFRSF11A TNFRSF11B TNFSF11
19 ischemic bone disease 10.2 TNFRSF11A TNFRSF11B TNFSF11
20 preretinal fibrosis 10.2 TNFRSF11A TNFRSF11B TNFSF11
21 intrahepatic cholestasis 10.2 TNFRSF11A TNFRSF11B TNFSF11
22 bladder papillary transitional cell neoplasm 10.1 TNFRSF11A TNFRSF11B TNFSF11
23 histiocytosis 10.1 TNFRSF11A TNFRSF11B TNFSF11
24 bone angioendothelial sarcoma 10.1 PTPN22 TNFRSF11B TNFSF11
25 molybdenum cofactor deficiency a 10.1 PTPN22 TNFRSF11B TNFSF11
26 aortic coarctation 10.1 IL2RA PTPN22
27 x-linked dominant intellectual disability-epilepsy syndrome 10.1 PTPN22 STAT4
28 chromosome 16q22 deletion syndrome 10.0 TNFRSF11A TNFSF11
29 anterior corneal pigmentation 10.0 FAS IL2RA PTPN22
30 prostatic urethral cancer 10.0 FAS IL2RA PTPN22
31 macrogyria, pseudobulbar palsy and mental retardation 10.0 FAS TYK2
32 diabetes mellitus, insulin-dependent, 12 10.0 FAS IL2RA PTPN22
33 articulation disorder 10.0 FAS PTPN22 STAT4
34 arthritis 9.9
35 goodpasture syndrome 9.9 FAS IL2RA STAT4
36 intracranial hemorrhage in brain cerebrovascular malformations 9.8 IL2RA IL2RB PTPN22
37 cousin syndrome 9.7 CD247 IL2RA PTPN22 STAT4
38 hereditary ataxia 9.6 FAS IL2RA IL2RB TYK2
39 t-cell prolymphocytic leukemia 8.8 ANKRD55 CD247 FAS IL2RA IL2RB PTPN2
40 non-amyloid monoclonal immunoglobulin deposition disease 8.8 ANKRD55 CD247 FAS IL2RA IL2RB PTPN2
41 polyomavirus allograft nephropathy 8.5 ANKRD55 CD247 FAS IL2RA IL2RB PTPN2

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Polyarticular Onset Juvenile Idiopathic Arthritis

MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.02 IL2RB PTPN2 PTPN22 STAT4 TNFRSF11A TNFSF11
2 hematopoietic system MP:0005397 10 CD247 FAS IL2RA IL2RB PTPN2 PTPN22
3 growth/size/body region MP:0005378 9.97 FAS IL2RA IL2RB PTPN2 PTPN22 TNFRSF11A
4 immune system MP:0005387 9.9 CD247 FAS IL2RA IL2RB PTPN2 PTPN22
5 mortality/aging MP:0010768 9.36 CD247 FAS IL2RA IL2RB PTPN2 PTPN22
6 limbs/digits/tail MP:0005371 9.35 TNFRSF11A TNFRSF11B TNFSF11 FAS PTPN2

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

Drugs for Polyarticular Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
2
Adalimumab Approved Phase 3 331731-18-1 16219006
3
Infliximab Approved Phase 3 170277-31-3
4
Abatacept Approved Phase 3 332348-12-6 10237
5
Etanercept Approved, Investigational Phase 3 185243-69-0
6
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
8 Folic Acid Antagonists Phase 3
9 Gastrointestinal Agents Phase 3
10 Nucleic Acid Synthesis Inhibitors Phase 3
11 Dermatologic Agents Phase 3
12 Vitamin B Complex Phase 3
13 Pharmaceutical Solutions Phase 3
14 Immunoglobulins Phase 3
15 Antibodies, Monoclonal Phase 3
16 Immunosuppressive Agents Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Antimetabolites Phase 3
19 Antimetabolites, Antineoplastic Phase 3
20 Antibodies Phase 3
21 Antirheumatic Agents Phase 3
22 Analgesics Phase 3
23 Analgesics, Non-Narcotic Phase 3
24 Peripheral Nervous System Agents Phase 3
25 Anti-Inflammatory Agents, Non-Steroidal Phase 3
26 Folate Nutraceutical Phase 3
27 Vitamin B9 Nutraceutical Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid Arthritis Completed NCT00690573 Phase 3
2 A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Juvenile Rheumatoid Arthritis Completed NCT00036374 Phase 3
3 BMS-188667 in Children and Adolescents With Juvenile Rheumatoid Arthritis Completed NCT00095173 Phase 3
4 Study of Human Anti-TNF Monoclonal Antibody Adalimumab in Children With Polyarticular Juvenile Idiopathic Arthritis (JIA) Completed NCT00048542 Phase 3
5 A Study to Evaluate the Pharmacokinetics, Efficacy and Safety of Intravenous Golimumab in Pediatric Participants With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate Therapy Recruiting NCT02277444 Phase 3
6 Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid Arthritis Terminated NCT00078806 Phase 3
7 Ultrasonography in Juvenile Idiopathic Arthritis Completed NCT01304420 Early Phase 1
8 Start Time Optimization of Biologics in Polyarticular JIA Recruiting NCT02593006

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

39
Bone

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

id Title Authors Year
1
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? ( 18802807 )
2008

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

Expression for Polyarticular Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for Polyarticular Onset Juvenile Idiopathic Arthritis

Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CD247 IL2RA IL2RB PTPN2 PTPN22 TNFRSF11A
2
Show member pathways
13.47 CD247 FAS IL2RA IL2RB TNFRSF11A TNFRSF11B
3
Show member pathways
13.27 CD247 FAS IL2RA IL2RB STAT4 TNFRSF11A
4
Show member pathways
13.18 IL2RA IL2RB PTPN2 TNFRSF11A TNFRSF11B TNFSF11
5
Show member pathways
13.1 FAS IL2RA IL2RB PTPN2 PTPN22 TNFRSF11A
6
Show member pathways
12.61 FAS IL2RA IL2RB TYK2
7
Show member pathways
12.45 CD247 IL2RA IL2RB STAT4 TYK2
8
Show member pathways
12.44 FAS TNFRSF11A TNFRSF11B TNFSF11
9
Show member pathways
12.2 TNFRSF11A TNFRSF11B TNFSF11
10 12.06 FAS TNFRSF11A TNFSF11
11 11.89 TNFRSF11A TNFRSF11B TNFSF11 TYK2
12
Show member pathways
11.79 IL2RA IL2RB PTPN2 STAT4 TYK2
13 11.77 FAS IL2RA IL2RB PTPN2 PTPN22 STAT4
14 11.71 IL2RA IL2RB STAT4
15
Show member pathways
11.63 FAS TNFRSF11A TNFRSF11B TNFSF11
16 11.45 IL2RA IL2RB STAT4 TYK2
17 11.43 IL2RA IL2RB STAT4
18
Show member pathways
11.41 CD247 IL2RA IL2RB STAT4 TYK2
19 11.4 TNFRSF11A TNFRSF11B TNFSF11
20 11.35 PTPN2 STAT4 TYK2
21
Show member pathways
11.34 CD247 IL2RA IL2RB STAT4
22
Show member pathways
11.33 FAS IL2RA IL2RB
23
Show member pathways
11.23 STAT4 TYK2
24 11.15 IL2RA IL2RB
25
Show member pathways
11.1 IL2RA STAT4 TYK2
26 11.06 CD247 IL2RA STAT4
27 10.75 TNFRSF11B TNFSF11
28 10.75 TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Polyarticular Onset Juvenile Idiopathic Arthritis

Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 FAS IL2RA IL2RB TNFRSF11A

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.84 FAS IL2RA TNFRSF11B TNFSF11
2 inflammatory response GO:0006954 9.76 FAS IL2RA TNFRSF11A TNFRSF11B
3 cytokine-mediated signaling pathway GO:0019221 9.69 IL2RB STAT4 TNFSF11
4 response to lipopolysaccharide GO:0032496 9.67 FAS PTPN22 TNFRSF11A TNFRSF11B
5 apoptotic signaling pathway GO:0097190 9.61 FAS TNFRSF11A TNFRSF11B
6 T cell differentiation GO:0030217 9.56 PTPN2 PTPN22
7 T cell homeostasis GO:0043029 9.55 FAS IL2RA
8 osteoclast differentiation GO:0030316 9.52 TNFRSF11A TNFSF11
9 negative regulation of T cell receptor signaling pathway GO:0050860 9.49 PTPN2 PTPN22
10 mammary gland alveolus development GO:0060749 9.48 TNFRSF11A TNFSF11
11 activation-induced cell death of T cells GO:0006924 9.4 FAS IL2RA
12 interleukin-2-mediated signaling pathway GO:0038110 9.32 IL2RA IL2RB
13 TNFSF11-mediated signaling pathway GO:0071847 9.26 TNFRSF11A TNFSF11
14 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.16 TNFRSF11A TNFSF11
15 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.96 TNFRSF11A TNFSF11
16 tumor necrosis factor-mediated signaling pathway GO:0033209 8.92 FAS TNFRSF11A TNFRSF11B TNFSF11

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase binding GO:1990782 9.26 CD247 PTPN22
2 interleukin-2 receptor activity GO:0004911 9.16 IL2RA IL2RB
3 interleukin-2 binding GO:0019976 8.96 IL2RA IL2RB
4 tumor necrosis factor-activated receptor activity GO:0005031 8.8 FAS TNFRSF11A TNFRSF11B

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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