MCID: PLY065
MIFTS: 27

Polyarticular Onset Juvenile Idiopathic Arthritis

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Polyarticular Onset Juvenile Idiopathic Arthritis:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 50
Polyarticular Juvenile Rheumatoid Arthritis 50 69
Juvenile Polyarthritis Rheumatoid Factor Negative 50
Juvenile Polyarthritis Rheumatoid Factor Positive 50
Juvenile Chronic Polyarthritis 69

Classifications:



Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards based summary : Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to rheumatoid arthritis and larynx leiomyosarcoma. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is TNFRSF11A (TNF Receptor Superfamily Member 11a), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Development Endothelin-1/EDNRA signaling. The drugs Adalimumab and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are craniofacial and limbs/digits/tail

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.6 TNFRSF11A TNFRSF11B TNFSF11
2 larynx leiomyosarcoma 10.1 TNFRSF11A TNFSF11
3 atrial fibrillation, familial, 8 10.1 TNFRSF11A TNFSF11
4 intrahepatic cholestasis 10.0 TNFRSF11A TNFSF11
5 arthritis 9.9
6 cortical blindness 9.9 TNFRSF11B TNFSF11
7 peripheral scars of retina 9.9 TNFRSF11B TNFSF11
8 bacillary angiomatosis 9.8 TNFRSF11B TNFSF11
9 pancreas adenocarcinoma 9.8 TNFRSF11A TNFSF11
10 van buchem disease, type 2 9.8 TNFRSF11B TNFSF11
11 ovarian insufficiency, familial 9.8 TNFRSF11B TNFSF11
12 psoriasis susceptibility 1 9.8 TNFRSF11B TNFSF11
13 neuropathy 9.8 TNFRSF11B TNFSF11
14 mesenchymal cell neoplasm 9.8 TNFRSF11B TNFSF11
15 carotenemia 9.8 TNFRSF11A TNFRSF11B
16 bacterial gastritis 9.7 TNFRSF11B TNFSF11
17 craniosynostosis 7 9.7 TNFRSF11B TNFSF11
18 synovium cancer 9.7 TNFRSF11B TNFSF11
19 atherosclerosis 9.7 TNFRSF11A TNFSF11
20 vulva fibroepithelial polyp 9.7 TNFRSF11B TNFSF11
21 glossopharyngeal nerve paralysis 9.7 TNFRSF11B TNFSF11
22 leprosy 4 9.6 TNFRSF11B TNFSF11
23 small cell cancer of the lung, somatic 9.5 TNFRSF11B TNFSF11
24 osteochondrosis 9.4 TNFRSF11B TNFSF11
25 polyembryoma 9.3 TNFRSF11A TNFRSF11B TNFSF11
26 tibial hemimelia 9.3 TNFRSF11A TNFRSF11B TNFSF11
27 paget disease of bone 2, early-onset 9.3 TNFRSF11A TNFRSF11B TNFSF11
28 hennekam van der horst syndrome 9.3 TNFRSF11A TNFRSF11B TNFSF11
29 spinocerebellar ataxia 4 9.3 TNFRSF11A TNFRSF11B TNFSF11
30 metaphyseal anadysplasia 2 9.3 TNFRSF11A TNFRSF11B TNFSF11
31 lower clivus meningioma 9.3 TNFRSF11A TNFRSF11B TNFSF11
32 bronchus cancer 9.3 TNFRSF11A TNFRSF11B TNFSF11
33 bone resorption disease 9.3 TNFRSF11A TNFRSF11B TNFSF11
34 glossitis 9.3 TNFRSF11A TNFRSF11B TNFSF11
35 physical disorder 9.3 TNFRSF11A TNFRSF11B TNFSF11
36 bone deterioration disease 9.3 TNFRSF11A TNFRSF11B TNFSF11
37 preretinal fibrosis 9.3 TNFRSF11A TNFRSF11B TNFSF11
38 schizoaffective disorder 9.3 TNFRSF11A TNFRSF11B TNFSF11
39 inappropriate adh syndrome 9.3 TNFRSF11A TNFRSF11B TNFSF11
40 chylomicron retention disease 9.2 TNFRSF11A TNFRSF11B TNFSF11
41 cpt deficiency, hepatic, type ia 9.2 TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Polyarticular Onset Juvenile Idiopathic Arthritis

MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.13 TNFRSF11A TNFRSF11B TNFSF11
2 limbs/digits/tail MP:0005371 8.8 TNFRSF11A TNFRSF11B TNFSF11

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

Drugs for Polyarticular Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 3 331731-18-1 16219006
2
Infliximab Approved Phase 3 170277-31-3
3
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
4
Abatacept Approved Phase 3 332348-12-6 10237
5
Etanercept Approved, Investigational Phase 3 185243-69-0
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
8 Antibodies Phase 3
9 Antibodies, Monoclonal Phase 3
10 Anti-Inflammatory Agents Phase 3
11 Antirheumatic Agents Phase 3
12 Immunoglobulins Phase 3
13 Antimetabolites Phase 3
14 Antimetabolites, Antineoplastic Phase 3
15 Dermatologic Agents Phase 3
16 Folic Acid Antagonists Phase 3
17 Gastrointestinal Agents Phase 3
18 Immunosuppressive Agents Phase 3
19 Nucleic Acid Synthesis Inhibitors Phase 3
20 Vitamin B Complex Phase 3
21 Pharmaceutical Solutions Phase 3
22 Analgesics Phase 3
23 Analgesics, Non-Narcotic Phase 3
24 Anti-Inflammatory Agents, Non-Steroidal Phase 3
25 Peripheral Nervous System Agents Phase 3
26 Folate Nutraceutical Phase 3
27 Vitamin B9 Nutraceutical Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid Arthritis Completed NCT00690573 Phase 3
2 A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Juvenile Rheumatoid Arthritis Completed NCT00036374 Phase 3 Infliximab
3 BMS-188667 in Children and Adolescents With Juvenile Rheumatoid Arthritis Completed NCT00095173 Phase 3 Abatacept;Placebo;Abatacept
4 Study of Human Anti-TNF Monoclonal Antibody Adalimumab in Children With Polyarticular Juvenile Idiopathic Arthritis (JIA) Completed NCT00048542 Phase 3 OLE BSA Adalimumab +/- MTX;OLE FD Adalimumab +/- MTX
5 A Study to Evaluate the Pharmacokinetics, Efficacy and Safety of Intravenous Golimumab in Pediatric Participants With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate Therapy Recruiting NCT02277444 Phase 3 Golimumab;Methotrexate
6 Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid Arthritis Terminated NCT00078806 Phase 3 Enbrel;Placebo
7 Ultrasonography in Juvenile Idiopathic Arthritis Completed NCT01304420 Early Phase 1
8 Start Time Optimization of Biologics in Polyarticular JIA Recruiting NCT02593006

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

39
Bone

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

id Title Authors Year
1
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? ( 18802807 )
2008

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

Expression for Polyarticular Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for Polyarticular Onset Juvenile Idiopathic Arthritis

Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 TNFRSF11A TNFRSF11B TNFSF11
2
Show member pathways
12.26 TNFRSF11A TNFRSF11B TNFSF11
3
Show member pathways
12.14 TNFRSF11A TNFRSF11B TNFSF11
4
Show member pathways
11.99 TNFRSF11A TNFSF11
5
Show member pathways
11.94 TNFRSF11A TNFRSF11B TNFSF11
6 11.79 TNFRSF11A TNFSF11
7 11.54 TNFRSF11A TNFRSF11B TNFSF11
8 11.47 TNFRSF11A TNFSF11
9 11.43 TNFRSF11A TNFSF11
10
Show member pathways
11.32 TNFRSF11A TNFSF11
11
Show member pathways
11.26 TNFRSF11A TNFRSF11B TNFSF11
12 10.79 TNFRSF11A TNFRSF11B TNFSF11
13 10.47 TNFRSF11B TNFSF11
14 10 TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Polyarticular Onset Juvenile Idiopathic Arthritis

Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.8 TNFRSF11A TNFRSF11B TNFSF11

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.51 TNFRSF11A TNFRSF11B
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.49 TNFRSF11A TNFSF11
3 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.48 TNFRSF11A TNFSF11
4 ossification GO:0001503 9.46 TNFRSF11A TNFSF11
5 apoptotic signaling pathway GO:0097190 9.43 TNFRSF11A TNFRSF11B
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 TNFRSF11A TNFRSF11B TNFSF11
7 monocyte chemotaxis GO:0002548 9.4 TNFRSF11A TNFSF11
8 osteoclast differentiation GO:0030316 9.37 TNFRSF11A TNFSF11
9 mammary gland alveolus development GO:0060749 9.32 TNFRSF11A TNFSF11
10 TNFSF11-mediated signaling pathway GO:0071847 9.16 TNFRSF11A TNFSF11
11 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFRSF11A TNFSF11
12 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.62 TNFRSF11A TNFSF11

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.16 TNFRSF11A TNFRSF11B
2 cytokine activity GO:0005125 8.96 TNFRSF11B TNFSF11
3 tumor necrosis factor-activated receptor activity GO:0005031 8.62 TNFRSF11A TNFRSF11B

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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