MCID: PLY065
MIFTS: 38

Polyarticular Onset Juvenile Idiopathic Arthritis malady

Categories: Rare diseases, Eye diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Sources:
65UMLS, 45NIH Rare Diseases, 51Orphanet, 28ICD10 via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Polyarticular Onset Juvenile Idiopathic Arthritis:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 45
Polyarticular Juvenile Rheumatoid Arthritis 45 65
Juvenile Polyarthritis Rheumatoid Factor Positive 45
Juvenile Polyarthritis Rheumatoid Factor Negative 45
Juvenile Rheumatoid Factor-Negative Polyarthritis 51
 
Juvenile Rheumatoid Factor-Positive Polyarthritis 51
Polyarthritis Without Rheumatoid Factor 51
Polyarthritis with Rheumatoid Factor 51
Juvenile Chronic Polyarthritis 65

Characteristics:

Orphanet epidemiological data:

51
juvenile rheumatoid factor-negative polyarthritis:
Inheritance: Multigenic/multifactorial; Age of death: normal life expectancy
juvenile rheumatoid factor-positive polyarthritis:
Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet51 85408, 85435
ICD10 via Orphanet28 M08.3, M08.0
ICD1027 M13.0
UMLS65 C0311221

Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards based summary: Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to juvenile rheumatoid factor-negative polyarthritis without anti-nuclear antibodies and juvenile rheumatoid factor-negative polyarthritis with anti-nuclear antibodies, and has symptoms including abnormality of the teeth, arthritis and limitation of joint mobility. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is PTPN2 (Protein Tyrosine Phosphatase, Non-Receptor Type 2), and among its related pathways are Inflammatory Response Pathway and TSLP Signaling Pathway. Affiliated tissues include eye and bone, and related mouse phenotypes are limbs/digits/tail and skeleton.

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

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Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile rheumatoid factor-negative polyarthritis without anti-nuclear antibodies12.9
2juvenile rheumatoid factor-negative polyarthritis with anti-nuclear antibodies12.9
3juvenile rheumatoid arthritis11.8
4degenerative myopia10.4TNFRSF11B, TNFSF11
5intrahepatic biliary papillomatosis10.4TNFRSF11B, TNFSF11
6mucocele of appendix10.3TNFRSF11B, TNFSF11
7atrial fibrillation, familial, 810.3TNFRSF11A, TNFSF11
8collagenopathy, types ii and xi10.3TNFRSF11B, TNFSF11
9cyclosporiasis10.3
10acrodermatitis chronica atrophicans10.3TNFRSF11B, TNFSF11
11achondroplasia10.3
12obsessive-compulsive disorder10.3
13wiskott-aldrich syndrome10.3
14atherosclerosis10.3
15asbestosis10.3
16biliary atresia10.3
17merkel cell carcinoma10.3
18triploidy10.3
19bone structure disease10.3TNFRSF11B, TNFSF11
20hemorrhagic fever10.3TNFRSF11A, TNFRSF11B, TNFSF11
21paget disease of bone 2, early-onset10.2TNFRSF11A, TNFRSF11B, TNFSF11
22tibial hemimelia10.2TNFRSF11A, TNFRSF11B, TNFSF11
23marcus gunn phenomenon10.2TNFRSF11A, TNFRSF11B, TNFSF11
24foster-kennedy syndrome10.2TNFRSF11B, TNFSF11
25aapoai amyloidosis10.2PTPN22, STAT4
26mononeuritis of upper limb10.2TNFRSF11A, TNFRSF11B, TNFSF11
27pulmonary neuroendocrine tumor10.2TNFRSF11A, TNFRSF11B, TNFSF11
28chromosomal disease10.2TNFRSF11B, TNFSF11
29glycoproteinosis10.2PTPN22, TNFRSF11B, TNFSF11
30leprosy 410.1PTPN22, TNFRSF11B, TNFSF11
31goat milk allergy10.1IL2RA, TNFSF11
32van buchem disease, type 210.0TNFRSF11B, TNFSF11
33asphyxia neonatorum9.9PTPN22, STAT4, TNFRSF11A, TNFSF11
34rh isoimmunization9.9FAS, PTPN22, STAT4
35lymphomatous thyroiditis9.8FAS, TYK2
36bestrophinopathy9.8FAS, PTPN22, STAT4
37smoking as a quantitative trait locus 19.7FAS, IL2RA, IL2RB
38hepatitis9.7FAS, IL2RA, TYK2
39hypocalciuric hypercalcemia, type i9.6FAS, IL2RA, STAT4
40rheumatoid arthritis9.4IL2RA, PTPN22, STAT4, TNFRSF11A, TNFRSF11B, TNFSF11
41systemic lupus erythematosus9.0CD247, FAS, IL2RA, PTPN22, STAT4
42wild type abeta2m amyloidosis8.0ANKRD55, CD247, FAS, IL2RA, IL2RB, PTPN2
43polycystic bone disease7.5ANKRD55, CD247, FAS, IL2RA, IL2RB, PTPN2

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to polyarticular onset juvenile idiopathic arthritis

Symptoms for Polyarticular Onset Juvenile Idiopathic Arthritis

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Symptoms:

 51 (show all 9)
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • joint/articular deformation
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • micrognathia/retrognathia/micrognathism/retrognathism

HPO human phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

(show all 9)
id Description Frequency HPO Source Accession
1 abnormality of the teeth hallmark (90%) HP:0000164
2 arthritis hallmark (90%) HP:0001369
3 limitation of joint mobility hallmark (90%) HP:0001376
4 joint swelling hallmark (90%) HP:0001386
5 arthralgia hallmark (90%) HP:0002829
6 autoimmunity hallmark (90%) HP:0002960
7 abnormality of the teeth typical (50%) HP:0000164
8 micrognathia typical (50%) HP:0000347
9 autoimmunity occasional (7.5%) HP:0002960

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

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Drugs for Polyarticular Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AbataceptapprovedPhase 3139332348-12-610237
Synonyms:
CTLA4-Ig
CTLA4-IgG4m
 
CTLA4Ig
CTLA4IgG4m
Orencia
2
MethotrexateapprovedPhase 314441959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
Methopterin
Methotextrate
 
Methotrate
Methotrexat
Methotrexate
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metoject
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Otrexup
Rasuvo
Rheumatrex
Rheumatrex Dose Pack
Trexall
3
InfliximabapprovedPhase 3349170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
4
AdalimumabapprovedPhase 3443331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
5
Etanerceptapproved, investigationalPhase 3383185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
6
Folic Acidapproved, nutraceuticalPhase 3292459-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
7Immunologic FactorsPhase 318483
8Immunosuppressive AgentsPhase 310422
9Pharmaceutical SolutionsPhase 37004
10AntibodiesPhase 34477
11Antibodies, MonoclonalPhase 32413
12Gastrointestinal AgentsPhase 36401
13Anti-Inflammatory AgentsPhase 38478
14Antirheumatic AgentsPhase 38496
15ImmunoglobulinsPhase 34477
16Dermatologic AgentsPhase 34555
17Vitamin B ComplexPhase 32847
18Nucleic Acid Synthesis InhibitorsPhase 33836
19Folic Acid AntagonistsPhase 31643
20AntimetabolitesPhase 39454
21Antimetabolites, AntineoplasticPhase 35770
22Anti-Inflammatory Agents, Non-SteroidalPhase 33549
23Peripheral Nervous System AgentsPhase 318510
24Analgesics, Non-NarcoticPhase 35184
25AnalgesicsPhase 39358
26FolateNutraceuticalPhase 32924
27Vitamin B9NutraceuticalPhase 32924
28Folinic AcidNutraceuticalPhase 32604

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid ArthritisCompletedNCT00690573Phase 3
2A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Juvenile Rheumatoid ArthritisCompletedNCT00036374Phase 3
3BMS-188667 in Children and Adolescents With Juvenile Rheumatoid ArthritisCompletedNCT00095173Phase 3
4Study of Human Anti-TNF Monoclonal Antibody Adalimumab in Children With Polyarticular Juvenile Idiopathic Arthritis (JIA)CompletedNCT00048542Phase 3
5A Study to Evaluate the Pharmacokinetics, Efficacy and Safety of Intravenous Golimumab in Pediatric Participants With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate TherapyRecruitingNCT02277444Phase 3
6Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid ArthritisTerminatedNCT00078806Phase 3
7Ultrasonography in Juvenile Idiopathic ArthritisCompletedNCT01304420Phase 0
8Start Time Optimization of Biologics in Polyarticular JIARecruitingNCT02593006

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

33
Eye, Bone

Animal Models for Polyarticular Onset Juvenile Idiopathic Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.2FAS, PTPN2, TNFRSF11A, TNFRSF11B, TNFSF11
2MP:00053907.5FAS, PTPN2, TNFRSF11A, TNFRSF11B, TNFSF11, TYK2
3MP:00053797.5CD247, FAS, IL2RB, PTPN2, PTPN22, STAT4
4MP:00053786.6FAS, IL2RA, IL2RB, PTPN2, PTPN22, TNFRSF11A
5MP:00107685.9CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22
6MP:00053875.7CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22
7MP:00053975.5CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Giant congenital melanocytic nevi and neurocutaneous melanosis. (25722729)
2015

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL2RA, IL2RB
29.8IL2RA, STAT4
39.5PTPN2, STAT4, TYK2
49.5IL2RA, IL2RB, STAT4
5
Show member pathways
9.4IL2RA, STAT4, TYK2
6
Show member pathways
9.4FAS, IL2RA, IL2RB
79.3TNFRSF11B, TNFSF11
89.3CD247, IL2RA, STAT4
99.2IL2RA, IL2RB, STAT4, TYK2
10
Show member pathways
9.1FAS, IL2RA, IL2RB, TYK2
11
Show member pathways
9.0CD247, IL2RA, IL2RB, STAT4
12
Show member pathways
8.9IL2RA, IL2RB, PTPN2, STAT4, TYK2
13
Show member pathways
8.7CD247, IL2RA, IL2RB, STAT4, TYK2
14
Show member pathways
8.7CD247, IL2RA, IL2RB, STAT4, TYK2
158.5TNFRSF11A, TNFRSF11B, TNFSF11
168.5TNFRSF11A, TNFRSF11B, TNFSF11
178.2TNFRSF11A, TNFRSF11B, TNFSF11, TYK2
18
Show member pathways
8.1FAS, TNFRSF11A, TNFRSF11B, TNFSF11
19
Show member pathways
8.1FAS, TNFRSF11A, TNFRSF11B, TNFSF11
20
Show member pathways
7.5FAS, IL2RA, IL2RB, PTPN2, PTPN22, TNFRSF11A
21
Show member pathways
7.4CD247, FAS, PTPN2, TNFRSF11A, TNFRSF11B, TNFSF11
22
Show member pathways
7.3CD247, FAS, IL2RA, IL2RB, STAT4, TNFRSF11A
23
Show member pathways
6.8CD247, IL2RA, IL2RB, PTPN2, TNFRSF11A, TNFRSF11B
24
Show member pathways
6.6CD247, FAS, IL2RA, IL2RB, TNFRSF11A, TNFRSF11B

GO Terms for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1interleukin-2-mediated signaling pathwayGO:003811010.5IL2RA, IL2RB
2T cell differentiationGO:003021710.4PTPN2, PTPN22
3activation-induced cell death of T cellsGO:000692410.3FAS, IL2RA
4T cell homeostasisGO:004302910.1FAS, IL2RA
5negative regulation of T cell receptor signaling pathwayGO:00508609.9PTPN2, PTPN22
6positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:00718489.8TNFRSF11A, TNFSF11
7response to cytokineGO:00340979.7FAS, TNFRSF11A
8TNFSF11-mediated signaling pathwayGO:00718479.7TNFRSF11A, TNFSF11
9osteoclast differentiationGO:00303169.6TNFRSF11A, TNFSF11
10cytokine-mediated signaling pathwayGO:00192219.4PTPN2, STAT4, TNFSF11, TYK2
11monocyte chemotaxisGO:00025489.4TNFRSF11A, TNFSF11
12apoptotic signaling pathwayGO:00971909.0FAS, TNFRSF11A, TNFRSF11B
13inflammatory responseGO:00069548.8IL2RA, TNFRSF11A, TNFRSF11B
14immune responseGO:00069558.7FAS, IL2RA, TNFRSF11B, TNFSF11
15response to lipopolysaccharideGO:00324968.0FAS, PTPN22, TNFRSF11A, TNFRSF11B

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet