MCID: PLY065
MIFTS: 46

Polyarticular Onset Juvenile Idiopathic Arthritis malady

Rare diseases, Eye diseases, Respiratory diseases, Bone diseases categories

Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards based summary: Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to juvenile rheumatoid arthritis and arthritis, and has symptoms including abnormality of the teeth, arthritis and limitation of joint mobility. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is CD247 (CD247 molecule), and among its related pathways are IL2-mediated signaling events and IL2 signaling events mediated by PI3K. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include bone and eye, and related mouse phenotypes are digestive/alimentary and cellular.

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Sources:
42NIH Rare Diseases, 48Orphanet, 61UMLS, 27ICD10 via Orphanet, 26ICD10
See all sources

Polyarticular Onset Juvenile Idiopathic Arthritis, Aliases & Descriptions:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 42 61
Polyarticular Juvenile Rheumatoid Arthritis 42 61
Juvenile Polyarthritis Rheumatoid Factor Positive 42
Juvenile Polyarthritis Rheumatoid Factor Negative 42
 
Juvenile Rheumatoid Factor-Negative Polyarthritis 48
Juvenile Rheumatoid Factor-Positive Polyarthritis 48
Polyarthritis Without Rheumatoid Factor 48
Polyarthritis with Rheumatoid Factor 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
juvenile rheumatoid factor-negative polyarthritis:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000; Age of death: Normal
juvenile rheumatoid factor-positive polyarthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


External Ids:

ICD10 via Orphanet27 M08.3, M08.0
ICD1026 M13.0

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

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Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile rheumatoid arthritis31.9IL2RA, IL2RB
2arthritis30.8PTPN22, IL2RB
3rheumatoid arthritis30.6IL2RA, IL2RB, TYK2, STAT4, PTPN22, FAS
4systemic lupus erythematosus29.5IL2RB, CD247, IL2RA, TYK2, PTPN22, FAS
5juvenile rheumatoid factor-negative polyarthritis without anti-nuclear antibodies10.6
6juvenile rheumatoid factor-negative polyarthritis with anti-nuclear antibodies10.6
7uveitis10.5IL2RA
8aortic valve insufficiency10.4
9lupus erythematosus10.4
10mannose-binding lectin deficiency10.4
11endotheliitis10.4
12posterior uveitis10.3IL2RB, IL2RA
13thyroiditis10.3PTPN22
14tropical spastic paraparesis10.3IL2RA, IL2RB
15extrinsic allergic alveolitis10.3IL2RA, IL2RB
16acute graft versus host disease10.3IL2RB, IL2RA
17gamma chain deficiency10.3IL2RB, IL2RA
1821-hydroxylase deficiency10.3IL2RA, IL2RB
19common variable immunodeficiency10.3IL2RB, IL2RA
20hairy cell leukemia10.3IL2RA, IL2RB
21pulmonary sarcoidosis10.3IL2RB, IL2RA
22vogt-koyanagi-harada disease10.3FAS, IL2RA
23peripheral t-cell lymphoma10.3IL2RA, IL2RB
24pulmonary tuberculosis10.3IL2RA, CD247
25autoimmune lymphoproliferative syndrome10.2FAS, IL2RA
26mycosis fungoides10.2IL2RB, IL2RA
27anaplastic large cell lymphoma10.2IL2RB, IL2RA
28splenomegaly10.2IL2RA, FAS
29diphtheria10.2IL2RA, IL2RB
30hodgkin's lymphoma10.2CD247, IL2RA, IL2RB
31sezary's disease10.2IL2RA, IL2RB, STAT4
32hepatitis10.1IL2RB, FAS
33cutaneous t cell lymphoma10.1IL2RA, FAS, IL2RB
34graft versus host disease10.1IL2RA, IL2RB, FAS
35severe combined immunodeficiency10.1IL2RA, IL2RB, TYK2
36chronic lymphocytic leukemia10.1FAS, IL2RA, IL2RB
37t-cell leukemia10.1IL2RA, IL2RB, FAS
38non-hodgkin lymphoma10.1IL2RB, FAS, IL2RA
39systemic scleroderma10.0IL2RA, PTPN22, IL2RB
40sjogren's syndrome10.0IL2RA, FAS
41connective tissue disease10.0PTPN22, IL2RA
42hypersensitivity reaction type ii disease10.0PTPN22, IL2RA
43eosinophilia10.0IL2RB, IL2RA
44autoimmune thyroiditis10.0PTPN22, FAS, IL2RA
45graves' disease10.0PTPN22, FAS, IL2RA
46kidney cancer10.0IL2RA, FAS, IL2RB, CD247
47viral infectious disease10.0IL2RA, IL2RB, CD247, FAS
48multiple sclerosis9.9PTPN22, IL2RA, IL2RB, STAT4
49lymphopenia9.8PTPN22, FAS, IL2RB, IL2RA
50ipex syndrome9.8STAT4, FAS, CD247, IL2RA, IL2RB

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to polyarticular onset juvenile idiopathic arthritis

Symptoms for Polyarticular Onset Juvenile Idiopathic Arthritis

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Symptoms:

 48 (show all 9)
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • joint/articular deformation
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • micrognathia/retrognathia/micrognathism/retrognathism

HPO human phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

(show all 9)
id Description Frequency HPO Source Accession
1 abnormality of the teeth hallmark (90%) HP:0000164
2 arthritis hallmark (90%) HP:0001369
3 limitation of joint mobility hallmark (90%) HP:0001376
4 joint swelling hallmark (90%) HP:0001386
5 arthralgia hallmark (90%) HP:0002829
6 autoimmunity hallmark (90%) HP:0002960
7 abnormality of the teeth typical (50%) HP:0000164
8 micrognathia typical (50%) HP:0000347
9 autoimmunity occasional (7.5%) HP:0002960

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

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Drug clinical trials:

Search ClinicalTrials for Polyarticular Onset Juvenile Idiopathic Arthritis

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

32
Bone, Eye

Animal Models for Polyarticular Onset Juvenile Idiopathic Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053817.8PTPN2, PTPN22, FAS, IL2RA
2MP:00053847.7CD247, FAS, PTPN22, PTPN2, TYK2
3MP:00053787.2TYK2, PTPN2, PTPN22, FAS, IL2RA, IL2RB
4MP:00053976.7CD247, TYK2, PTPN2, PTPN22, FAS, STAT4
5MP:00053876.6TYK2, PTPN2, PTPN22, FAS, STAT4, IL2RA
6MP:00107686.5TYK2, PTPN2, PTPN22, FAS, STAT4, IL2RA

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

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Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? (18802807)
2008

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Expression patterns in normal tissues for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL-2 Signaling pathway37
9.8IL2RB, IL2RA
2
Show member pathways
IL2 signaling events mediated by STAT537
9.8IL2RB, IL2RA
39.8IL2RB, IL2RA
4
Show member pathways
Immune response IL 3 activation and signaling pathway59
9.8IL2RB, IL2RA
59.7STAT4, IL2RA
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway59
9.5STAT4, TYK2
79.5TYK2, STAT4
8
Show member pathways
9.5TYK2, STAT4
9
Show member pathways
IL27-mediated signaling events37
9.5STAT4, TYK2
109.4CD247, IL2RA, STAT4
11
Show member pathways
9.3IL2RB, IL2RA, STAT4
12
Show member pathways
9.2FAS, IL2RA, IL2RB
13
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway59
9.2IL2RB, IL2RA, TYK2
14
Show member pathways
9.2IL2RB, IL2RA, TYK2
159.2TYK2, IL2RA, IL2RB
16
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.2FAS, STAT4, CD247
179.2IL2RA, STAT4, TYK2
18
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.0STAT4, IL2RA, IL2RB, CD247
19
Show member pathways
8.8TYK2, STAT4, IL2RA, IL2RB
20
Show member pathways
Type III interferon signaling37
8.8TYK2, STAT4, IL2RA, IL2RB
21
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
8.8CD247, FAS, PTPN2
22
Show member pathways
8.7IL2RB, IL2RA, FAS, TYK2
23
Show member pathways
8.7TYK2, FAS, IL2RA, IL2RB
248.6PTPN22, FAS, IL2RA, IL2RB
25
Show member pathways
Immune response IL 22 signaling pathway59
G protein signaling N RAS regulation pathway59
8.5TYK2, STAT4, IL2RA, IL2RB, CD247
26
Show member pathways
Immune response IL 12 induced IFN gamma production59
8.5CD247, IL2RB, IL2RA, STAT4, TYK2
27
Show member pathways
8.4TYK2, PTPN2, IL2RA, IL2RB
28
Show member pathways
8.3PTPN2, PTPN22, IL2RA, IL2RB

Compounds for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Compounds related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1lentinan4410.2IL2RB, IL2RA
2mycophenolate4410.2IL2RB, IL2RA
3thymoglobulin4410.2IL2RA, IL2RB
4denileukin diftitox44 50 1212.2IL2RB, IL2RA
5delta9-tetrahydrocannabinol4410.2IL2RB, IL2RA
6daclizumab44 1211.2IL2RB, IL2RA
7basiliximab44 1211.2IL2RA, IL2RB
8alemtuzumab44 1211.2IL2RB, IL2RA
9levamisole44 1211.1IL2RB, IL2RA
10cuprophan4410.1IL2RB, IL2RA
11polysulfone4410.1IL2RB, IL2RA
12mycophenolic acid44 50 1212.1IL2RA, IL2RB
13phorbol 12,13-dibutyrate4410.1IL2RB, IL2RA
14fitc4410.1IL2RA, IL2RB
15con a4410.1IL2RA, IL2RB
162,5-oligoadenylate4410.0IL2RA, IL2RB
17mycophenolate mofetil44 50 1212.0IL2RB, IL2RA
18il 104410.0IL2RB, IL2RA
19erythromycin44 3 50 1213.0IL2RB, IL2RA
20lactose44 1211.0IL2RB, IL2RA
21pentoxifylline44 1210.9IL2RB, IL2RA
222-chlorodeoxyadenosine449.9FAS, IL2RA
23neopterin449.9IL2RB, IL2RA
24okt3449.7FAS, IL2RA, IL2RB
25infliximab44 50 1211.7IL2RB, IL2RA, FAS
26ivig449.7IL2RB, IL2RA, FAS
27prednisolone44 29 1211.7FAS, IL2RA, IL2RB
28ionomycin449.6IL2RB, IL2RA, FAS
29aspirin44 50 29 2512.6IL2RB, IL2RA, FAS
30rantes449.6FAS, IL2RA, IL2RB
31n acetylcysteine449.6IL2RB, IL2RA, FAS
32anisomycin44 1210.6IL2RA, FAS
33polysaccharide449.6IL2RB, IL2RA, FAS
34rapamycin449.5IL2RB, IL2RA, FAS
35genistein44 29 60 3 25 1214.5IL2RB, IL2RA, FAS
36gp 130449.5IL2RA, FAS, TYK2
37cyclosporin a44 29 6011.5FAS, IL2RA, IL2RB
38melatonin44 29 60 25 1213.5IL2RB, IL2RA
39thymidine44 2510.4FAS, IL2RA, IL2RB
40cisplatin44 50 60 1212.3IL2RB, IL2RA, FAS
41creatinine449.2FAS, IL2RA, IL2RB
42dexamethasone44 50 29 1212.2IL2RB, IL2RA, STAT4, FAS
43ifn-alpha449.2TYK2, FAS, IL2RA, IL2RB
44aspartate449.1IL2RB, IL2RA, FAS
45phosphotyrosine448.8TYK2, PTPN2, STAT4, IL2RB
46phosphatidylinositol448.4TYK2, FAS, STAT4, IL2RA, IL2RB, CD247
47serine448.2TYK2, PTPN2, FAS, STAT4, IL2RB
48arginine447.9PTPN2, PTPN22, FAS, IL2RA, IL2RB, CD247
49tyrosine447.0CD247, TYK2, PTPN2, PTPN22, FAS, STAT4

GO Terms for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2IL2RB, IL2RA, FAS

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation-induced cell death of T cellsGO:0069249.6IL2RA, FAS
2negative regulation of inflammatory responseGO:0507289.3IL2RA, PTPN2
3negative regulation of T cell receptor signaling pathwayGO:0508609.0PTPN2, PTPN22
4T cell differentiationGO:0302178.9PTPN22, PTPN2
5peptidyl-tyrosine dephosphorylationGO:0353358.7PTPN22, PTPN2
6cytokine-mediated signaling pathwayGO:0192218.5IL2RB, STAT4, PTPN2, TYK2

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:0049119.8IL2RB, IL2RA
2interleukin-2 bindingGO:0199769.7IL2RB, IL2RA
3kinase bindingGO:0199009.0FAS, PTPN22
4protein tyrosine phosphatase activityGO:0047259.0PTPN22, PTPN2

Products for genes affiliated with Polyarticular Onset Juvenile Idiopathic Arthritis

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  • Antibodies
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  • Kits and Assays

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet