MCID: PLY010
MIFTS: 29

Polyclonal Hypergammaglobulinemia malady

Immune diseases category

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 38NCIt, 25ICD10
See all sources

Polyclonal Hypergammaglobulinemia, Aliases & Descriptions:

Name: Polyclonal Hypergammaglobulinemia 9 11 43 60
 
Polyclonal Hypergammaglobulinemia Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


External Ids:

Disease Ontology9 DOID:2344
ICD9CM27 273.0
NCIt38 C35885
ICD1025 D89.0

Summaries for Polyclonal Hypergammaglobulinemia

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MalaCards based summary: Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to leukemia and rheumatoid arthritis. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways is B Cell Receptor Signaling Pathway. The compounds sandoglobulin and bucillamine have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone marrow.

Related Diseases for Polyclonal Hypergammaglobulinemia

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Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to polyclonal hypergammaglobulinemia

Symptoms for Polyclonal Hypergammaglobulinemia

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Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

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Drug clinical trials:

Search ClinicalTrials for Polyclonal Hypergammaglobulinemia

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

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Anatomical Context for Polyclonal Hypergammaglobulinemia

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MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

31
T cells, B cells, Bone marrow, Bone, Smooth muscle, Colon, Skin, Myeloid, Tongue

Animal Models for Polyclonal Hypergammaglobulinemia or affiliated genes

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Publications for Polyclonal Hypergammaglobulinemia

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Articles related to Polyclonal Hypergammaglobulinemia:

(show all 23)
idTitleAuthorsYear
1
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. (21316456)
2011
2
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. (19586961)
2009
3
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. (19008139)
2009
4
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. (18336788)
2008
5
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. (15802958)
2005
6
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. (14765269)
2004
7
Decreased anion gap in polyclonal hypergammaglobulinemia. (11937082)
2002
8
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
9
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. (10550554)
1999
10
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. (9786355)
1998
11
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. (9185918)
1997
12
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. (8589372)
1995
13
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. (7812213)
1994
14
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. (8432045)
1993
15
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (1633368)
1992
16
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. (1650855)
1991
17
Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. (2386010)
1990
18
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. (3318265)
1987
19
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. (3777978)
1986
20
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. (6230148)
1984
21
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (6464210)
1984
22
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. (78444)
1978
23
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. (4123735)
1973

Variations for Polyclonal Hypergammaglobulinemia

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Expression for genes affiliated with Polyclonal Hypergammaglobulinemia

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Search GEO for disease gene expression data for Polyclonal Hypergammaglobulinemia.

Pathways for genes affiliated with Polyclonal Hypergammaglobulinemia

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Pathways related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.3CD79A, IL6

Compounds for genes affiliated with Polyclonal Hypergammaglobulinemia

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Compounds related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

(show all 19)
idCompoundScoreTop Affiliating Genes
1sandoglobulin439.7CD79A, IL6
2bucillamine439.7IL6, CD79A
3pmma439.6IL6, CD79A
4adalimumab43 49 1211.6IL6, CD79A
5okt3439.6CD79A, IL6
6ivig439.6CD79A, IL6
7melphalan43 49 1211.6IL6, CD79A
8neopterin439.6CD79A, IL6
9rituximab43 49 1211.6CD79A, IL6
10prednisolone43 28 1211.6IL6, CD79A
11hyaluronic acid43 2410.5CD79A, IL6
12methotrexate49 43 1211.5IL6, CD79A
13epinephrine43 24 1211.5CD79A, IL6
14n acetylcysteine439.4IL6, CD79A
15indomethacin43 28 59 1212.4IL6, CD79A
16vitamin d439.3IL6, CD79A
17histamine43 28 2411.3IL6, CD79A
18fibrinogen439.2IL6, CD79A
19norepinephrine43 24 1211.0CD79A, IL6

GO Terms for genes affiliated with Polyclonal Hypergammaglobulinemia

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Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.3CD79A, IL6

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:00424939.4IL6, SRP54
2response to heatGO:00094088.8CRNN, IL6

Products for genes affiliated with Polyclonal Hypergammaglobulinemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Polyclonal Hypergammaglobulinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet