MCID: PLY010
MIFTS: 33

Polyclonal Hypergammaglobulinemia malady

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Summaries for Polyclonal Hypergammaglobulinemia

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MalaCards: Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to leukemia and hairy cell leukemia. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways is B Cell Receptor Signaling Pathway. The compounds sandoglobulin and bucillamine have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and skin.

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 40NCIt, 58SNOMED-CT
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Aliases & Descriptions:

polyclonal hypergammaglobulinemia 8 10 45 62
polyclonal hypergammaglobulinemia nos 8


External Ids:

Disease Ontology8 DOID:2344
ICD9CM27 273.0
NCIt40 C35885

Related Diseases for Polyclonal Hypergammaglobulinemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to polyclonal hypergammaglobulinemia

Symptoms for Polyclonal Hypergammaglobulinemia

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Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Polyclonal Hypergammaglobulinemia

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

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Anatomical Context for Polyclonal Hypergammaglobulinemia

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33MalaCards
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MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

33
T cells, B cells, Skin, Tongue, Bone, Bone marrow, Smooth muscle, Colon, Myeloid

Animal Models for Polyclonal Hypergammaglobulinemia or affiliated genes

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Publications for Polyclonal Hypergammaglobulinemia

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52PubMed
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Articles related to Polyclonal Hypergammaglobulinemia:

(show all 23)
idTitleAuthorsYear
1
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. (21316456)
2011
2
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. (19586961)
2009
3
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. (19008139)
2009
4
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. (18336788)
2008
5
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. (15802958)
2005
6
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. (14765269)
2004
7
Decreased anion gap in polyclonal hypergammaglobulinemia. (11937082)
2002
8
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
9
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. (10550554)
1999
10
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. (9786355)
1998
11
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. (9185918)
1997
12
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. (8589372)
1995
13
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. (7812213)
1994
14
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. (8432045)
1993
15
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (1633368)
1992
16
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. (1650855)
1991
17
Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. (2386010)
1990
18
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. (3318265)
1987
19
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. (3777978)
1986
20
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. (6230148)
1984
21
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (6464210)
1984
22
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. (78444)
1978
23
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. (4123735)
1973

Variations for Polyclonal Hypergammaglobulinemia

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Expression for genes affiliated with Polyclonal Hypergammaglobulinemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyclonal Hypergammaglobulinemia

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Pathways for genes affiliated with Polyclonal Hypergammaglobulinemia

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50PathCards, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.3CD79A, IL6

Compounds for genes affiliated with Polyclonal Hypergammaglobulinemia

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience
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Compounds related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1sandoglobulin459.7CD79A, IL6
2bucillamine459.7CD79A, IL6
3pmma459.6CD79A, IL6
4adalimumab45 51 1111.6CD79A, IL6
5okt3459.6IL6, CD79A
6ivig459.6CD79A, IL6
7melphalan45 51 1111.6CD79A, IL6
8neopterin459.6IL6, CD79A
9rituximab45 51 1111.6CD79A, IL6
10prednisolone45 29 1111.6IL6, CD79A
11hyaluronic acid45 2410.5CD79A, IL6
12methotrexate51 45 1111.5CD79A, IL6
13epinephrine45 24 1111.5IL6, CD79A
14n acetylcysteine459.4CD79A, IL6
15indomethacin45 29 61 1112.4IL6, CD79A
16vitamin d459.3CD79A, IL6
17histamine45 29 2411.3CD79A, IL6
18fibrinogen459.2CD79A, IL6
19norepinephrine45 24 1111.0CD79A, IL6

GO Terms for genes affiliated with Polyclonal Hypergammaglobulinemia

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16Gene Ontology
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Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3CD79A, IL6

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:0424939.4IL6, SRP54
2response to heatGO:0094088.8CRNN, IL6

Products for genes affiliated with Polyclonal Hypergammaglobulinemia

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Polyclonal Hypergammaglobulinemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet