MCID: PLY010
MIFTS: 32

Polyclonal Hypergammaglobulinemia malady

Categories: Immune diseases, Metabolic diseases

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

About this section

Aliases & Descriptions for Polyclonal Hypergammaglobulinemia:

Name: Polyclonal Hypergammaglobulinemia 11 49 13 67
 
Polyclonal Hypergammaglobulinemia Nos 11

Classifications:



External Ids:

Disease Ontology11 DOID:2344
ICD1029 D89.0
ICD9CM31 273.0
NCIt44 C35885

Summaries for Polyclonal Hypergammaglobulinemia

About this section
MalaCards based summary: Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to histiocytosis-lymphadenopathy plus syndrome and tetanus. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (Interleukin 6), and among its related pathways are Malaria and Cytokines and Inflammatory Response. Affiliated tissues include t cells, b cells and tongue.

Related Diseases for Polyclonal Hypergammaglobulinemia

About this section

Diseases related to Polyclonal Hypergammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 263)
idRelated DiseaseScoreTop Affiliating Genes
1histiocytosis-lymphadenopathy plus syndrome11.3
2tetanus10.4CD79A, SLC29A3
3lymphocytic colitis10.4CD79A, IL6
4cerebellopontine angle primitive neuroectodermal10.4CD79A, IL6
5disease_ontology10.4CD40LG, IL6
6philophthalmiasis10.4CD79A, IL6
7calcific tendinitis10.4CD40LG, CD79A
8medullary sponge kidney10.4CD40LG, CD79A
9variola major10.4CD40LG, CD79A
10mu chain disease10.4CD40LG, CD79A
11retinal cancer10.4CD40LG, CD79A
12focal embolic glomerulonephritis10.4CD40LG, CD79A
13heart disease10.4CD40LG, CD79A
14endometrial stromal nodule10.4CD40LG, CD79A
15chronic cystitis10.4CD40LG, CD79A
16van benthem-driessen-hanveld syndrome10.4CD40LG, CD79A
17hemolytic-uremic syndrome10.4CD40LG, CD79A
18partial motor epilepsy10.4CD40LG, CD79A
19benign meningioma10.4CD40LG, CD79A
20parasitic helminthiasis infectious disease10.4CD40LG, CD79A
21occlusion of gallbladder10.4CD40LG, CD79A
22viral meningitis10.3CD40LG, CD79A
23substance-induced psychosis10.3CD40LG, CD79A
24gamma heavy chain disease10.3CD40LG, CD79A
25regional ureteric cancer10.3CD40LG, CD79A
26arteriosclerosis10.3CD40LG, CD79A
27pompholyx10.3CD40LG, CD79A
28bacterial conjunctivitis10.3CD40LG, CD79A
29deep keratitis10.3CD40LG, CD79A
30juvenile type testicular granulosa cell tumor10.3CD40LG, CD79A
31testicular brenner tumor10.3CD40LG, CD79A
32diabetic angiopathy10.3CD40LG, CD79A
33fallopian tube leiomyosarcoma10.3CD40LG, CD79A
34syphilitic encephalitis10.3CD40LG, IL6
35adult extraosseous chondrosarcoma10.3CD40LG, CD79A
36brucella abortus brucellosis10.3CD40LG, CD79A
37small intestinal vasoactive intestinal peptide producing tumor10.3CD40LG, CD79A
38aniseikonia10.3CD40LG, CD79A
39b cell linker protein deficiency10.3CD40LG, CD79A
40post-traumatic stress disorder10.3CD40LG, CD79A
41granular cell tumor10.3CD40LG, CD79A
42urinary bladder posterior wall cancer10.3CD79A, IL6
43spinocerebellar ataxia, autosomal recessive 1010.3CD40LG, CD79A
44adie pupil10.3CD40LG, CD79A
45sweat gland cancer10.3CD40LG, IL6
46laryngeal cartilage cancer10.3CD40LG, CD79A
47lung abscess10.3CD40LG, CD79A
48hypoparathyroidism, x-linked10.3CD40LG, CD79A
49ileocolitis10.3CD40LG, CD79A
50glanders10.3CD40LG, CD79A

Comorbidity relations with Polyclonal Hypergammaglobulinemia via Phenotypic Disease Network (PDN):


Deficiency AnemiaHeart Disease
Acute Cystitis

Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to polyclonal hypergammaglobulinemia

Symptoms for Polyclonal Hypergammaglobulinemia

About this section

Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

About this section

Drugs for Polyclonal Hypergammaglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunoglobulins6045
2Autoantibodies126
3Antibodies6045

Interventional clinical trials:

idNameStatusNCT IDPhase
1Auto-antibodies Prevalence and CD1 Role in Gaucher DiseaseCompletedNCT02650219

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

About this section

Anatomical Context for Polyclonal Hypergammaglobulinemia

About this section

MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

35
T cells, B cells, Tongue, Myeloid, Skin, Bone, Smooth muscle

Animal Models for Polyclonal Hypergammaglobulinemia or affiliated genes

About this section

Publications for Polyclonal Hypergammaglobulinemia

About this section

Articles related to Polyclonal Hypergammaglobulinemia:

(show all 24)
idTitleAuthorsYear
1
A Case of Lethal Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Medical Challenge for the Forensic Pathologist. (27364300)
2016
2
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. (21316456)
2011
3
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. (19586961)
2009
4
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. (19008139)
2009
5
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. (18336788)
2008
6
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. (15802958)
2005
7
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. (14765269)
2004
8
Decreased anion gap in polyclonal hypergammaglobulinemia. (11937082)
2002
9
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
10
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. (10550554)
1999
11
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. (9786355)
1998
12
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. (9185918)
1997
13
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. (8589372)
1995
14
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. (7812213)
1994
15
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. (8432045)
1993
16
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (1633368)
1992
17
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. (1650855)
1991
18
Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. (2386010)
1990
19
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. (3318265)
1987
20
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. (3777978)
1986
21
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. (6230148)
1984
22
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (6464210)
1984
23
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. (78444)
1978
24
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. (4123735)
1973

Variations for Polyclonal Hypergammaglobulinemia

About this section

Expression for genes affiliated with Polyclonal Hypergammaglobulinemia

About this section
Search GEO for disease gene expression data for Polyclonal Hypergammaglobulinemia.

Pathways for genes affiliated with Polyclonal Hypergammaglobulinemia

About this section

GO Terms for genes affiliated with Polyclonal Hypergammaglobulinemia

About this section

Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.0CD2, CD4, CD40LG, CD79A, IL6

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:00421009.8CD40LG, CD79A
2defense response to Gram-negative bacteriumGO:00508299.5CD4, IL6
3positive regulation of T cell proliferationGO:00421029.0CD4, CD40LG, IL6
4T cell activationGO:00421108.7CD2, CD4, IL6

Sources for Polyclonal Hypergammaglobulinemia

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet