MCID: PLY010
MIFTS: 28

Polyclonal Hypergammaglobulinemia malady

Immune diseases, Metabolic diseases categories

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 42NCIt, 59SNOMED-CT, 29ICD9CM, 27ICD10
See all sources

Aliases & Descriptions for Polyclonal Hypergammaglobulinemia:

Name: Polyclonal Hypergammaglobulinemia 10 47 12 65
 
Polyclonal Hypergammaglobulinemia Nos 10


Classifications:



External Ids:

Disease Ontology10 DOID:2344
NCIt42 C35885
ICD9CM29 273.0
ICD1027 D89.0

Summaries for Polyclonal Hypergammaglobulinemia

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MalaCards based summary: Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to leukemia and histiocytosis-lymphadenopathy plus syndrome. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (Interleukin 6), and among its related pathways are Malaria and Cytokines and Inflammatory Response. Affiliated tissues include bone, t cells and b cells.

Related Diseases for Polyclonal Hypergammaglobulinemia

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Diseases related to Polyclonal Hypergammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia10.5
2histiocytosis-lymphadenopathy plus syndrome10.4
3rheumatoid arthritis10.2
4hepatocellular carcinoma10.2
5arthritis10.2
6autoimmune hepatitis10.2
7b-cell lymphomas10.2
8hepatitis10.2
9mantle cell lymphoma10.2
10visceral leishmaniasis10.2
11blue toe syndrome10.2
12histiocytosis10.2
13leishmaniasis10.2
14myeloid leukemia10.2
15bone marrow necrosis10.2
16anterior cerebral artery infarction10.2CD40LG, IL6
17compensatory emphysema10.2CD79A, SLC29A3
18acute allergic sanguinous otitis media10.2CD79A, IL6
19hemorrhagic proctocolitis10.2CD40LG, IL6
20human granulocytic anaplasmosis10.2CD40LG, IL6
21olecranon bursitis10.2CD40LG, CD79A
22bilateral hyperactive labyrinth10.2CD40LG, CD79A
23calabro syndrome10.2CD40LG, CD79A
24pulmonary edema10.2CD40LG, CD79A
25ovarian malignant mesothelioma10.2CD40LG, CD79A
26photoallergic dermatitis10.2CD40LG, CD79A
27tuberculous epididymitis10.2CD40LG, CD79A
28mammary paget's disease10.2CD40LG, CD79A
29atopic dermatitis10.2CD40LG, CD79A
30sarcoma10.2CD40LG, CD79A
31bilateral retinoblastoma10.2CD40LG, CD79A
32cryoglobulinemia, familial mixed10.2CD40LG, CD79A
33lichen planus10.2CD40LG, CD79A
34clear cell cystadenofibroma10.2CD40LG, CD79A
35immunotactoid glomerulopathy10.2CD40LG, CD79A
36cocaine dependence10.2CD40LG, CD79A
37hepatic cystic hamartoma10.2CD40LG, CD79A
38traumatic glaucoma10.2CD40LG, CD79A
39early myoclonic encephalopathy10.2CD40LG, CD79A
40chorea gravidarum10.2CD40LG, CD79A
41typhoid fever10.2CD40LG, CD79A
42conjunctival cancer10.2CD40LG, CD79A
43hemangioblastoma10.2CD40LG, CD79A
44parotid gland cancer10.2CD40LG, CD79A
45sella turcica neoplasm10.2CD40LG, CD79A
46hyperostosis10.2CD40LG, CD79A
47oculo cerebro acral syndrome10.2CD40LG, CD79A
4846 xx gonadal dysgenesis10.2CD40LG, CD79A
49central sleep apnea10.2CD40LG, CD79A
50enteric pattern testicular yolk sac tumor10.2CD40LG, CD79A

Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to polyclonal hypergammaglobulinemia

Symptoms for Polyclonal Hypergammaglobulinemia

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Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Auto-antibodies Prevalence and CD1 Role in Gaucher DiseaseCompletedNCT02650219

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

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Anatomical Context for Polyclonal Hypergammaglobulinemia

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MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

33
Bone, T cells, B cells, Tongue, Myeloid, Skin, Smooth muscle

Animal Models for Polyclonal Hypergammaglobulinemia or affiliated genes

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Publications for Polyclonal Hypergammaglobulinemia

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Articles related to Polyclonal Hypergammaglobulinemia:

(show all 23)
idTitleAuthorsYear
1
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. (21316456)
2011
2
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. (19586961)
2009
3
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. (19008139)
2009
4
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. (18336788)
2008
5
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. (15802958)
2005
6
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. (14765269)
2004
7
Decreased anion gap in polyclonal hypergammaglobulinemia. (11937082)
2002
8
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
9
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. (10550554)
1999
10
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. (9786355)
1998
11
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. (9185918)
1997
12
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. (8589372)
1995
13
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. (7812213)
1994
14
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. (8432045)
1993
15
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (1633368)
1992
16
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. (1650855)
1991
17
Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. (2386010)
1990
18
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. (3318265)
1987
19
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. (3777978)
1986
20
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. (6230148)
1984
21
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (6464210)
1984
22
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. (78444)
1978
23
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. (4123735)
1973

Variations for Polyclonal Hypergammaglobulinemia

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Expression for genes affiliated with Polyclonal Hypergammaglobulinemia

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Search GEO for disease gene expression data for Polyclonal Hypergammaglobulinemia.

Pathways for genes affiliated with Polyclonal Hypergammaglobulinemia

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Pathways related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CD40LG, IL6
29.5CD4, IL6
38.9CD4, CD40LG, CD79A
48.9CD4, CD40LG, CD79A
5
B cell receptor signaling pathway (KEGG)
Show member pathways
8.5CD4, CD40LG, CD79A

GO Terms for genes affiliated with Polyclonal Hypergammaglobulinemia

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Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.5CD4, CD40LG, CD79A, IL6

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1defense response to Gram-negative bacteriumGO:00508299.5CD4, IL6
2T cell activationGO:00421109.5CD4, IL6
3B cell proliferationGO:00421009.2CD40LG, CD79A

Sources for Polyclonal Hypergammaglobulinemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet