MCID: PLY010
MIFTS: 37

Polyclonal Hypergammaglobulinemia malady

Summaries for Polyclonal Hypergammaglobulinemia

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MalaCards: Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to hairy cell leukemia and histiocytosis. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Cytokines and Inflammatory Response and Th17 Differentiation. The compounds sandoglobulin and bucillamine have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and skin, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

polyclonal hypergammaglobulinemia 8 10 44 60
polyclonal hypergammaglobulinemia nos 8


External Ids:

Disease Ontology8 DOID:2344
ICD9CM27 273.0
NCIt39 C35885

Related Diseases for Polyclonal Hypergammaglobulinemia

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17GeneCards, 18GeneDecks
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Diseases related to Polyclonal Hypergammaglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1hairy cell leukemia30.4ITGAX
2histiocytosis30.2SLC29A3
3leukemia10.4
4colon lymphoma10.1
5acute myeloid leukemia10.1
6visceral leishmaniasis10.1
7autoimmune hepatitis10.1
8blue toe syndrome10.1
9mantle cell lymphoma10.1
10acute leukemia10.1
11arthritis10.1
12hepatitis10.1
13hepatocellular carcinoma10.1
14leishmaniasis10.1
15myeloid leukemia10.1
16rheumatoid arthritis10.1
17histiocytosis-lymphadenopathy plus syndrome10.1
18paraneoplastic syndromes10.0IL6
19peripheral vascular disease10.0CD79A
20agammaglobulinemia10.0CD79A
21bronchiectasis10.0CD79A
22human immunodeficiency virus infectious disease10.0CD79A
23bronchitis10.0CD79A
24polyneuropathy10.0CD79A
25lupus nephritis10.0CD79A
26exanthem10.0CD79A
27atherosclerosis10.0IL6
28proliferative glomerulonephritis10.0CD79A
29sjogren's syndrome10.0CD79A
30celiac disease10.0CD79A
31pemphigus foliaceus10.0CD79A
32nephritis10.0CD79A
33rhinitis10.0CD79A
34q fever10.0CD79A
35brucellosis10.0CD79A
36lupus erythematosus10.0CD79A
37pertussis10.0CD79A
38lymphatic system disease10.0CD4
39mycobacterium avium complex disease10.0CD4
40uveitis10.0CD4
41listeriosis10.0CD4
42leprosy10.0CD4
43alopecia10.0CD4
44lymphopenia10.0IL6
45reactive arthritis10.0CD79A
46myocarditis10.0CD4
47cryptococcosis10.0CD4
48histoplasmosis10.0CD4
49mesangial proliferative glomerulonephritis10.0IL6, CD79A
50sarcoidosis10.0CD4

Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to polyclonal hypergammaglobulinemia

Clinical Features for Polyclonal Hypergammaglobulinemia

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Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Polyclonal Hypergammaglobulinemia

Drug clinical trials:

Search ClinicalTrials for Polyclonal Hypergammaglobulinemia

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Search CenterWatch for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

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Anatomical Context for Polyclonal Hypergammaglobulinemia

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32MalaCards
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MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

32
T cells, B cells, Skin, Bone, Tongue, Bone marrow, Myeloid, Smooth muscle, Colon

Animal Models for Polyclonal Hypergammaglobulinemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polyclonal Hypergammaglobulinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.9ITGAX, CD4, CD79A, IL6, SLC29A3
2MP:00053977.6ITGAX, CD4, CD79A, IL6, SLC29A3

Publications for Polyclonal Hypergammaglobulinemia

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50PubMed
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Articles related to Polyclonal Hypergammaglobulinemia:

(show all 24)
idTitleAuthorsYear
1
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. (21316456)
2011
2
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. (19586961)
2009
3
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. (19008139)
2009
4
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. (18336788)
2008
5
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. (15802958)
2005
6
Polyclonal proliferation of plasma cells associated with marked hypergammaglobulinemia in an elderly patient. (15717691)
2005
7
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. (14765269)
2004
8
Decreased anion gap in polyclonal hypergammaglobulinemia. (11937082)
2002
9
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
10
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. (10550554)
1999
11
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. (9786355)
1998
12
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. (9185918)
1997
13
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. (8589372)
1995
14
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. (7812213)
1994
15
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. (8432045)
1993
16
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (1633368)
1992
17
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. (1650855)
1991
18
Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. (2386010)
1990
19
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. (3318265)
1987
20
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. (3777978)
1986
21
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. (6230148)
1984
22
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (6464210)
1984
23
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. (78444)
1978
24
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. (4123735)
1973

Genetic Variations for Polyclonal Hypergammaglobulinemia

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Expression for genes affiliated with Polyclonal Hypergammaglobulinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyclonal Hypergammaglobulinemia

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Pathways for genes affiliated with Polyclonal Hypergammaglobulinemia

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37NCBI BioSystems Database, 52R&D Systems, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Polyclonal Hypergammaglobulinemia

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1sandoglobulin449.9IL6, CD79A
2bucillamine449.9IL6, CD79A
3adalimumab44 49 1111.8IL6, CD79A
4pmma449.8CD79A, IL6
5okt3449.8CD79A, IL6
6hemocyanin449.8CD79A, CD4
7dextran sulfate449.7IL6, CD4
8mannan449.7CD79A, CD4
9dipyridamole44 59 28 1112.7SLC29A3, CD79A
10ivig449.6CD79A, IL6
11rituximab44 49 1111.6IL6, CD79A
12neopterin449.4IL6, CD79A, CD4
13melphalan44 1110.3IL6, CD79A
14pge2449.0IL6, CD79A, CD4
15mannose448.9ITGAX, CD4, CD79A
16fibrinogen448.9IL6, CD79A, ITGAX

GO Terms for genes affiliated with Polyclonal Hypergammaglobulinemia

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16Gene Ontology
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Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.3IL6, CD79A, CD4, ITGAX

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.6IL6, CD4
2defense response to Gram-negative bacteriumGO:0508299.5IL6, CD4
3response to heatGO:0094089.2IL6, CRNN

Products for genes affiliated with Polyclonal Hypergammaglobulinemia

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  • Antibodies
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Sources for Polyclonal Hypergammaglobulinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet