MCID: PLY010
MIFTS: 31

Polyclonal Hypergammaglobulinemia malady

Categories: Immune diseases, Metabolic diseases

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

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Aliases & Descriptions for Polyclonal Hypergammaglobulinemia:

Name: Polyclonal Hypergammaglobulinemia 11 13 48 66
 
Polyclonal Hypergammaglobulinemia Nos 11

Classifications:



External Ids:

Disease Ontology11 DOID:2344
ICD1028 D89.0
ICD9CM30 273.0
NCIt43 C35885

Summaries for Polyclonal Hypergammaglobulinemia

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MalaCards based summary: Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to hepatic vein thrombosis and histiocytosis-lymphadenopathy plus syndrome. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (Interleukin 6), and among its related pathways are Malaria and IgA-Producing B Cells in the Intestine. Affiliated tissues include t cells, b cells and tongue.

Related Diseases for Polyclonal Hypergammaglobulinemia

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Diseases related to Polyclonal Hypergammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 269)
idRelated DiseaseScoreTop Affiliating Genes
1hepatic vein thrombosis10.4CD40LG, SLC29A3
2histiocytosis-lymphadenopathy plus syndrome10.4
3disease_ontology10.4CD40LG, IL6
4syphilitic encephalitis10.4CD40LG, IL6
5sweat gland cancer10.4CD40LG, IL6
6human monocytic ehrlichiosis10.4CD40LG, IL6
7leukostasis10.3CD40LG, IL6
8tetanus10.3CD79A, SLC29A3
9bile duct signet ring cell carcinoma10.3CD40LG, IL6
10lymphocytic colitis10.3CD79A, IL6
11lymphoma10.3
12cerebellopontine angle primitive neuroectodermal10.3CD79A, IL6
13calcific tendinitis10.3CD40LG, CD79A
14eyelid degenerative disease10.3CD40LG, IL6
15medullary sponge kidney10.3CD40LG, CD79A
16variola major10.3CD40LG, CD79A
17mu chain disease10.3CD40LG, CD79A
18chronic apical periodontitis10.3CD40LG, IL6
19calcium metabolism disease10.3CD40LG, CD79A
20retinal cancer10.3CD40LG, CD79A
21focal embolic glomerulonephritis10.3CD40LG, CD79A
22membranous glomerulonephritis10.3CD40LG, CD79A
23heart disease10.3CD40LG, CD79A
24endometrial stromal nodule10.3CD40LG, CD79A
25chronic cystitis10.3CD40LG, CD79A
26van benthem-driessen-hanveld syndrome10.3CD40LG, CD79A
27hemolytic-uremic syndrome10.3CD40LG, CD79A
28partial motor epilepsy10.3CD40LG, CD79A
29benign meningioma10.3CD40LG, CD79A
30parasitic helminthiasis infectious disease10.3CD40LG, CD79A
31occlusion of gallbladder10.3CD40LG, CD79A
32viral meningitis10.3CD40LG, CD79A
33substance-induced psychosis10.3CD40LG, CD79A
34gamma heavy chain disease10.3CD40LG, CD79A
35regional ureteric cancer10.3CD40LG, CD79A
36arteriosclerosis10.3CD40LG, CD79A
37pompholyx10.3CD40LG, CD79A
38bacterial conjunctivitis10.3CD40LG, CD79A
39philophthalmiasis10.3CD79A, IL6
40deep keratitis10.3CD40LG, CD79A
41juvenile type testicular granulosa cell tumor10.3CD40LG, CD79A
42testicular brenner tumor10.3CD40LG, CD79A
43oculo cerebro osseous syndrome10.3CD40LG, CD79A
44diabetic angiopathy10.3CD40LG, CD79A
45retroperitoneal fibrosis10.3CD40LG, IL6
46fallopian tube leiomyosarcoma10.3CD40LG, CD79A
47adult extraosseous chondrosarcoma10.3CD40LG, CD79A
48esophagus melanoma10.2CD40LG, IL6
49brucella abortus brucellosis10.2CD40LG, CD79A
50small intestinal vasoactive intestinal peptide producing tumor10.2CD40LG, CD79A

Comorbidity relations with Polyclonal Hypergammaglobulinemia via Phenotypic Disease Network (PDN):


Acute CystitisDeficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to polyclonal hypergammaglobulinemia

Symptoms for Polyclonal Hypergammaglobulinemia

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Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Auto-antibodies Prevalence and CD1 Role in Gaucher DiseaseCompletedNCT02650219

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

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Anatomical Context for Polyclonal Hypergammaglobulinemia

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MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

34
T cells, B cells, Tongue, Myeloid, Skin, Bone, Smooth muscle

Animal Models for Polyclonal Hypergammaglobulinemia or affiliated genes

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Publications for Polyclonal Hypergammaglobulinemia

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Articles related to Polyclonal Hypergammaglobulinemia:

(show all 24)
idTitleAuthorsYear
1
A Case of Lethal Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Medical Challenge for the Forensic Pathologist. (27364300)
2016
2
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. (21316456)
2011
3
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. (19586961)
2009
4
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. (19008139)
2009
5
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. (18336788)
2008
6
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. (15802958)
2005
7
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. (14765269)
2004
8
Decreased anion gap in polyclonal hypergammaglobulinemia. (11937082)
2002
9
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
10
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. (10550554)
1999
11
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. (9786355)
1998
12
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. (9185918)
1997
13
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. (8589372)
1995
14
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. (7812213)
1994
15
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. (8432045)
1993
16
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (1633368)
1992
17
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. (1650855)
1991
18
Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. (2386010)
1990
19
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. (3318265)
1987
20
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. (3777978)
1986
21
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. (6230148)
1984
22
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (6464210)
1984
23
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. (78444)
1978
24
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. (4123735)
1973

Variations for Polyclonal Hypergammaglobulinemia

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Expression for genes affiliated with Polyclonal Hypergammaglobulinemia

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Search GEO for disease gene expression data for Polyclonal Hypergammaglobulinemia.

Pathways for genes affiliated with Polyclonal Hypergammaglobulinemia

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GO Terms for genes affiliated with Polyclonal Hypergammaglobulinemia

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Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098977.6CD2, CD4, CD40LG, CD79A, IL6

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:00421009.6CD40LG, CD79A
2B cell differentiationGO:00301839.5CD40LG, CD79A
3defense response to Gram-negative bacteriumGO:00508298.9CD4, IL6
4T cell activationGO:00421108.7CD2, CD4, IL6
5positive regulation of T cell proliferationGO:00421028.6CD4, CD40LG, IL6

Sources for Polyclonal Hypergammaglobulinemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet