MCID: PLY010
MIFTS: 32

Polyclonal Hypergammaglobulinemia malady

Categories: Immune diseases, Metabolic diseases

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

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Aliases & Descriptions for Polyclonal Hypergammaglobulinemia:

Name: Polyclonal Hypergammaglobulinemia 11 50 13 68
 
Polyclonal Hypergammaglobulinemia Nos 11

Classifications:



External Ids:

Disease Ontology11 DOID:2344
ICD1030 D89.0
ICD9CM32 273.0
NCIt45 C35885

Summaries for Polyclonal Hypergammaglobulinemia

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MalaCards based summary: Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to histiocytosis-lymphadenopathy plus syndrome and clostridium difficile colitis. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (Interleukin 6), and among its related pathways are Malaria and Cytokines and Inflammatory Response. Affiliated tissues include t cells, b cells and tongue.

Related Diseases for Polyclonal Hypergammaglobulinemia

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Diseases related to Polyclonal Hypergammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 242)
idRelated DiseaseScoreTop Affiliating Genes
1histiocytosis-lymphadenopathy plus syndrome11.3
2clostridium difficile colitis10.2CD79A, IL6
3supratentorial primitive neuroectodermal tumor10.2CD79A, IL6
4pneumocystosis10.2CD79A, SLC29A3
5inner ear disease10.2CD40LG, IL6
6mikulicz disease10.2CD79A, IL6
7reproductive system disease10.2CD40LG, IL6
8alcoholic neuropathy10.2CD40LG, CD79A
9camptodactyly vertebral fusion10.2CD40LG, CD79A
10spinal polio10.2CD40LG, CD79A
11rabies10.2CD40LG, CD79A
12unilateral retinoblastoma10.2CD40LG, CD79A
13mesangial proliferative glomerulonephritis10.2CD40LG, CD79A
14delta chain disease10.2CD40LG, CD79A
15discitis10.2CD40LG, CD79A
16spinal canal and spinal cord meningioma10.2CD40LG, CD79A
17trichostrongyloidiasis10.2CD40LG, CD79A
18heart septal defect10.2CD40LG, CD79A
19cutaneous polyarteritis nodosa10.2CD40LG, CD79A
20hypertensive heart disease10.2CD40LG, SLC29A3
21mild pre-eclampsia10.2CD40LG, CD79A
22pediatric meningioma10.2CD40LG, CD79A
23tonsil cancer10.2CD40LG, CD79A
24indomethacin antenatal infection10.2CD40LG, CD79A
25postcricoid region cancer10.2CD40LG, CD79A
26beach ear10.2CD40LG, CD79A
27acute kidney tubular necrosis10.2CD40LG, CD79A
28immune-complex glomerulonephritis10.2CD79A, IL6
29atheroembolism of kidney10.2CD40LG, CD79A
30partial sensory epilepsy10.2CD40LG, CD79A
31ritscher-schinzel syndrome 110.2CD40LG, CD79A
32diabetic angiopathy10.2CD40LG, CD79A
33gastric leiomyoma10.2CD40LG, IL6
34endocarditis10.2CD40LG, CD79A
35muscular dystrophy10.2CD40LG, CD79A
36dumping syndrome10.2CD40LG, CD79A
37striatonigral degeneration10.2CD40LG, CD79A
38ciliary body spindle cell melanoma10.2CD40LG, CD79A
39coenurosis10.2CD79A, IL6
40purulent endophthalmitis10.2CD40LG, CD79A
41mu chain disease10.2CD40LG, CD79A
42homocystinuria10.2CD40LG, CD79A
43mental retardation, autosomal dominant 1910.2CD40LG, CD79A
44hemangioma of orbit10.2CD40LG, CD79A
45leiomyosarcoma10.2CD40LG, CD79A
46gestational diabetes10.2CD40LG, CD79A
47conduct disorder10.2CD40LG, IL6
48odontogenic myxoma10.2CD40LG, CD79A
49chronic mucocutaneous candidiasis10.2CD40LG, CD79A
50primary thrombocytopenia10.2CD40LG, CD79A

Comorbidity relations with Polyclonal Hypergammaglobulinemia via Phenotypic Disease Network (PDN):


Deficiency AnemiaHeart Disease
Acute Cystitis

Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to polyclonal hypergammaglobulinemia

Symptoms & Phenotypes for Polyclonal Hypergammaglobulinemia

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Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

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Drugs for Polyclonal Hypergammaglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunoglobulins6394
2Autoantibodies130
3Antibodies6394

Interventional clinical trials:

idNameStatusNCT IDPhase
1Auto-antibodies Prevalence and CD1 Role in Gaucher DiseaseCompletedNCT02650219

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

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Anatomical Context for Polyclonal Hypergammaglobulinemia

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MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

36
T cells, B cells, Tongue, Myeloid, Skin, Bone, Smooth muscle

Publications for Polyclonal Hypergammaglobulinemia

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Articles related to Polyclonal Hypergammaglobulinemia:

(show all 24)
idTitleAuthorsYear
1
A Case of Lethal Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Medical Challenge for the Forensic Pathologist. (27364300)
2016
2
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. (21316456)
2011
3
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. (19586961)
2009
4
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. (19008139)
2009
5
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. (18336788)
2008
6
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. (15802958)
2005
7
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. (14765269)
2004
8
Decreased anion gap in polyclonal hypergammaglobulinemia. (11937082)
2002
9
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
10
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. (10550554)
1999
11
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. (9786355)
1998
12
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. (9185918)
1997
13
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. (8589372)
1995
14
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. (7812213)
1994
15
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. (8432045)
1993
16
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (1633368)
1992
17
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. (1650855)
1991
18
Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. (2386010)
1990
19
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. (3318265)
1987
20
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. (3777978)
1986
21
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. (6230148)
1984
22
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (6464210)
1984
23
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. (78444)
1978
24
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. (4123735)
1973

Variations for Polyclonal Hypergammaglobulinemia

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Expression for genes affiliated with Polyclonal Hypergammaglobulinemia

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Search GEO for disease gene expression data for Polyclonal Hypergammaglobulinemia.

Pathways for genes affiliated with Polyclonal Hypergammaglobulinemia

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GO Terms for genes affiliated with Polyclonal Hypergammaglobulinemia

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Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098977.9CD2, CD4, CD40LG, CD79A, IL6

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:004210010.3CD40LG, CD79A
2defense response to Gram-negative bacteriumGO:005082910.1CD4, IL6
3positive regulation of T cell proliferationGO:00421029.6CD4, CD40LG, IL6
4cell surface receptor signaling pathwayGO:00071669.3CD2, CD4, CD79A
5T cell activationGO:00421108.8CD2, CD4, IL6

Sources for Polyclonal Hypergammaglobulinemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet