MCID: PLY010
MIFTS: 32

Polyclonal Hypergammaglobulinemia malady

Categories: Immune diseases, Metabolic diseases

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

Aliases & Descriptions for Polyclonal Hypergammaglobulinemia:

Name: Polyclonal Hypergammaglobulinemia 12 52 14 69
Polyclonal Hypergammaglobulinemia Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2344
ICD10 33 D89.0
ICD9CM 35 273.0
NCIt 47 C35885
SNOMED-CT 64 190808009 190811005
UMLS 69 C0154254

Summaries for Polyclonal Hypergammaglobulinemia

MalaCards based summary : Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to histiocytosis-lymphadenopathy plus syndrome and clostridium difficile colitis. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (Interleukin 6), and among its related pathways/superpathways are NF-kappaB Signaling and T cell receptor signaling pathway. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and smooth muscle.

Related Diseases for Polyclonal Hypergammaglobulinemia

Diseases related to Polyclonal Hypergammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 242)
id Related Disease Score Top Affiliating Genes
1 histiocytosis-lymphadenopathy plus syndrome 11.3
2 clostridium difficile colitis 10.2 CD79A IL6
3 supratentorial primitive neuroectodermal tumor 10.2 CD79A IL6
4 pneumocystosis 10.2 CD79A SLC29A3
5 inner ear disease 10.2 CD40LG IL6
6 mikulicz disease 10.2 CD79A IL6
7 reproductive system disease 10.2 CD40LG IL6
8 alcoholic neuropathy 10.2 CD40LG CD79A
9 camptodactyly vertebral fusion 10.2 CD40LG CD79A
10 spinal polio 10.2 CD40LG CD79A
11 rabies 10.2 CD40LG CD79A
12 unilateral retinoblastoma 10.2 CD40LG CD79A
13 mesangial proliferative glomerulonephritis 10.2 CD40LG CD79A
14 delta chain disease 10.2 CD40LG CD79A
15 discitis 10.2 CD40LG CD79A
16 spinal canal and spinal cord meningioma 10.2 CD40LG CD79A
17 trichostrongyloidiasis 10.2 CD40LG CD79A
18 heart septal defect 10.2 CD40LG CD79A
19 cutaneous polyarteritis nodosa 10.2 CD40LG CD79A
20 hypertensive heart disease 10.2 CD40LG SLC29A3
21 mild pre-eclampsia 10.2 CD40LG CD79A
22 pediatric meningioma 10.2 CD40LG CD79A
23 tonsil cancer 10.2 CD40LG CD79A
24 indomethacin antenatal infection 10.2 CD40LG CD79A
25 postcricoid region cancer 10.2 CD40LG CD79A
26 beach ear 10.2 CD40LG CD79A
27 acute kidney tubular necrosis 10.2 CD40LG CD79A
28 immune-complex glomerulonephritis 10.2 CD79A IL6
29 atheroembolism of kidney 10.2 CD40LG CD79A
30 partial sensory epilepsy 10.2 CD40LG CD79A
31 ritscher-schinzel syndrome 1 10.2 CD40LG CD79A
32 diabetic angiopathy 10.2 CD40LG CD79A
33 gastric leiomyoma 10.2 CD40LG IL6
34 endocarditis 10.2 CD40LG CD79A
35 muscular dystrophy 10.2 CD40LG CD79A
36 dumping syndrome 10.2 CD40LG CD79A
37 striatonigral degeneration 10.2 CD40LG CD79A
38 ciliary body spindle cell melanoma 10.2 CD40LG CD79A
39 coenurosis 10.2 CD79A IL6
40 purulent endophthalmitis 10.2 CD40LG CD79A
41 mu chain disease 10.2 CD40LG CD79A
42 homocystinuria 10.2 CD40LG CD79A
43 mental retardation, autosomal dominant 19 10.2 CD40LG CD79A
44 hemangioma of orbit 10.2 CD40LG CD79A
45 leiomyosarcoma 10.2 CD40LG CD79A
46 gestational diabetes 10.2 CD40LG CD79A
47 conduct disorder 10.2 CD40LG IL6
48 odontogenic myxoma 10.2 CD40LG CD79A
49 chronic mucocutaneous candidiasis 10.2 CD40LG CD79A
50 primary thrombocytopenia 10.2 CD40LG CD79A

Comorbidity relations with Polyclonal Hypergammaglobulinemia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to Polyclonal Hypergammaglobulinemia

Symptoms & Phenotypes for Polyclonal Hypergammaglobulinemia

Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

Drugs for Polyclonal Hypergammaglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies
3 Autoantibodies

Interventional clinical trials:


id Name Status NCT ID Phase
1 Auto-antibodies Prevalence and CD1 Role in Gaucher Disease Completed NCT02650219

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

Anatomical Context for Polyclonal Hypergammaglobulinemia

MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

39
T Cells, B Cells, Smooth Muscle, Bone, Skin, Myeloid, Tongue

Publications for Polyclonal Hypergammaglobulinemia

Articles related to Polyclonal Hypergammaglobulinemia:

(show all 24)
id Title Authors Year
1
A Case of Lethal Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Medical Challenge for the Forensic Pathologist. ( 27364300 )
2016
2
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. ( 21316456 )
2011
3
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. ( 19586961 )
2009
4
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. ( 19008139 )
2009
5
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. ( 18336788 )
2008
6
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. ( 15802958 )
2005
7
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. ( 14765269 )
2004
8
Decreased anion gap in polyclonal hypergammaglobulinemia. ( 11937082 )
2002
9
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. ( 11399611 )
2000
10
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. ( 10550554 )
1999
11
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. ( 9786355 )
1998
12
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. ( 9185918 )
1997
13
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. ( 8589372 )
1995
14
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. ( 7812213 )
1994
15
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. ( 8432045 )
1993
16
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. ( 1633368 )
1992
17
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. ( 1650855 )
1991
18
[Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. ( 2386010 )
1990
19
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. ( 3318265 )
1987
20
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. ( 3777978 )
1986
21
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. ( 6230148 )
1984
22
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. ( 6464210 )
1984
23
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. ( 78444 )
1978
24
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. ( 4123735 )
1973

Variations for Polyclonal Hypergammaglobulinemia

Expression for Polyclonal Hypergammaglobulinemia

Search GEO for disease gene expression data for Polyclonal Hypergammaglobulinemia.

Pathways for Polyclonal Hypergammaglobulinemia

GO Terms for Polyclonal Hypergammaglobulinemia

Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 CD2 CD4 CD40LG CD79A IL6

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.43 CD2 CD4 CD79A
2 defense response to Gram-negative bacterium GO:0050829 9.32 CD4 IL6
3 B cell proliferation GO:0042100 9.16 CD40LG CD79A
4 positive regulation of T cell proliferation GO:0042102 9.13 CD4 CD40LG IL6
5 T cell activation GO:0042110 8.8 CD2 CD4 IL6

Sources for Polyclonal Hypergammaglobulinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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