MCID: PLY010
MIFTS: 33

Polyclonal Hypergammaglobulinemia malady

Summaries for Polyclonal Hypergammaglobulinemia

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MalaCards: Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to leukemia and hairy cell leukemia. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways is B Cell Receptor Signaling Pathway. The compounds sandoglobulin and bucillamine have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and skin.

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 41NCIt, 59SNOMED-CT
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Aliases & Descriptions:

polyclonal hypergammaglobulinemia 9 11 46 63
polyclonal hypergammaglobulinemia nos 9


External Ids:

Disease Ontology9 DOID:2344
ICD9CM28 273.0
NCIt41 C35885

Related Diseases for Polyclonal Hypergammaglobulinemia

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to polyclonal hypergammaglobulinemia

Symptoms for Polyclonal Hypergammaglobulinemia

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Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Polyclonal Hypergammaglobulinemia

Drug clinical trials:

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Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Search CenterWatch for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

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Anatomical Context for Polyclonal Hypergammaglobulinemia

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34MalaCards
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MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

34
T cells, B cells, Skin, Tongue, Bone, Bone marrow, Smooth muscle, Colon, Myeloid

Animal Models for Polyclonal Hypergammaglobulinemia or affiliated genes

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Publications for Polyclonal Hypergammaglobulinemia

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53PubMed
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Articles related to Polyclonal Hypergammaglobulinemia:

(show all 23)
idTitleAuthorsYear
1
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. (21316456)
2011
2
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. (19586961)
2009
3
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. (19008139)
2009
4
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. (18336788)
2008
5
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. (15802958)
2005
6
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. (14765269)
2004
7
Decreased anion gap in polyclonal hypergammaglobulinemia. (11937082)
2002
8
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
9
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. (10550554)
1999
10
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. (9786355)
1998
11
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. (9185918)
1997
12
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. (8589372)
1995
13
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. (7812213)
1994
14
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. (8432045)
1993
15
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (1633368)
1992
16
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. (1650855)
1991
17
Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. (2386010)
1990
18
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. (3318265)
1987
19
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. (3777978)
1986
20
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. (6230148)
1984
21
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (6464210)
1984
22
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. (78444)
1978
23
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. (4123735)
1973

Variations for Polyclonal Hypergammaglobulinemia

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Expression for genes affiliated with Polyclonal Hypergammaglobulinemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyclonal Hypergammaglobulinemia

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Pathways for genes affiliated with Polyclonal Hypergammaglobulinemia

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51PathCards, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.3CD79A, IL6

Compounds for genes affiliated with Polyclonal Hypergammaglobulinemia

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1sandoglobulin469.7CD79A, IL6
2bucillamine469.7CD79A, IL6
3pmma469.6CD79A, IL6
4adalimumab46 52 1211.6CD79A, IL6
5okt3469.6IL6, CD79A
6ivig469.6CD79A, IL6
7melphalan46 52 1211.6CD79A, IL6
8neopterin469.6IL6, CD79A
9rituximab46 52 1211.6CD79A, IL6
10prednisolone46 30 1211.6IL6, CD79A
11hyaluronic acid46 2510.5CD79A, IL6
12methotrexate52 46 1211.5CD79A, IL6
13epinephrine46 25 1211.5IL6, CD79A
14n acetylcysteine469.4CD79A, IL6
15indomethacin46 30 62 1212.4IL6, CD79A
16vitamin d469.3CD79A, IL6
17histamine46 30 2511.3CD79A, IL6
18fibrinogen469.2CD79A, IL6
19norepinephrine46 25 1211.0CD79A, IL6

GO Terms for genes affiliated with Polyclonal Hypergammaglobulinemia

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17Gene Ontology
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Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3CD79A, IL6

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:0424939.4IL6, SRP54
2response to heatGO:0094088.8CRNN, IL6

Products for genes affiliated with Polyclonal Hypergammaglobulinemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polyclonal Hypergammaglobulinemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet