MCID: PLY010
MIFTS: 34

Polyclonal Hypergammaglobulinemia

Categories: Immune diseases, Metabolic diseases

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

MalaCards integrated aliases for Polyclonal Hypergammaglobulinemia:

Name: Polyclonal Hypergammaglobulinemia 12 51 14 69
Polyclonal Hypergammaglobulinemia Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2344
ICD10 32 D89.0
ICD9CM 34 273.0
NCIt 46 C35885
SNOMED-CT 64 190808009 190811005
UMLS 69 C0154254

Summaries for Polyclonal Hypergammaglobulinemia

MalaCards based summary : Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to histiocytosis-lymphadenopathy plus syndrome and rhinoscleroma. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (Interleukin 6), and among its related pathways/superpathways are NF-kappaB Signaling and T cell receptor signaling pathway. The drugs Antibodies and Autoantibodies have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and tongue.

Related Diseases for Polyclonal Hypergammaglobulinemia

Diseases related to Polyclonal Hypergammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 histiocytosis-lymphadenopathy plus syndrome 11.4
2 rhinoscleroma 10.4 CD79A SLC29A3
3 microscopic colitis 10.3 CD79A IL6
4 vaginal disease 10.3 CD79A IL6
5 mesangial proliferative glomerulonephritis 10.3 CD79A IL6
6 primary amebic meningoencephalitis 10.3 CD79A IL6
7 selective igg deficiency disease 10.3 CD40LG CD79A
8 c1q nephropathy 10.3 CD40LG CD79A
9 meningovascular neurosyphilis 10.3 CD40LG CD79A
10 alpha chain disease 10.3 CD40LG CD79A
11 brill-zinsser disease 10.3 CD40LG CD79A
12 exudative glomerulonephritis 10.3 CD40LG CD79A
13 cork-handlers' disease 10.3 CD40LG CD79A
14 salpingo-oophoritis 10.3 CD40LG CD79A
15 early yaws 10.3 CD40LG CD79A
16 chronic interstitial cystitis 10.3 CD40LG CD79A
17 axillary adenitis 10.3 CD40LG CD79A
18 cryofibrinogenemia 10.3 CD40LG CD79A
19 trichostrongyloidiasis 10.3 CD40LG CD79A
20 gingival disease 10.3 CD79A IL6
21 subacute bacterial endocarditis 10.3 CD40LG CD79A
22 heterophyiasis 10.3 CD40LG CD79A
23 immunoglobulin g deficiency 10.3 CD40LG CD79A
24 orbital granuloma 10.3 CD40LG CD79A
25 transient arthritis 10.3 CD40LG IL6
26 transient hypogammaglobulinemia of infancy 10.3 CD40LG CD79A
27 central nervous system vasculitis 10.3 CD40LG IL6
28 hyperglobulinemic purpura 10.3 CD40LG CD79A
29 gastroduodenitis 10.3 CD40LG CD79A
30 proliferative glomerulonephritis 10.3 CD79A IL6
31 bacterial conjunctivitis 10.3 CD40LG CD79A
32 heavy chain disease 10.3 CD40LG CD79A
33 ophthalmia neonatorum 10.3 CD40LG CD79A
34 immunoglobulin a deficiency 1 10.3 CD40LG CD79A
35 parotid disease 10.3 CD40LG CD79A
36 cerebral arteritis 10.3 CD40LG CD79A
37 selective immunoglobulin deficiency disease 10.3 CD40LG CD79A
38 geniculate herpes zoster 10.3 CD40LG CD79A
39 erythema elevatum diutinum 10.3 CD40LG CD79A
40 sporotrichosis 10.3 CD40LG CD79A
41 fallopian tube disease 10.3 CD40LG CD79A
42 hyperimmunoglobulin syndrome 10.3 CD40LG CD79A
43 congenital syphilis 10.3 CD40LG CD79A
44 monoclonal paraproteinemia 10.3 CD40LG CD79A
45 salpingitis 10.3 CD40LG CD79A
46 ocular toxoplasmosis 10.3 CD40LG CD79A
47 parasitic ichthyosporea infectious disease 10.3 CD40LG CD79A
48 dysgammaglobulinemia 10.3 CD40LG CD79A
49 congenital hypogammaglobulinemia 10.3 CD40LG CD79A
50 acute maxillary sinusitis 10.3 CD40LG CD79A

Comorbidity relations with Polyclonal Hypergammaglobulinemia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to Polyclonal Hypergammaglobulinemia

Symptoms & Phenotypes for Polyclonal Hypergammaglobulinemia

Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

Drugs for Polyclonal Hypergammaglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Autoantibodies
3 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Auto-antibodies Prevalence and CD1 Role in Gaucher Disease Completed NCT02650219

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

Anatomical Context for Polyclonal Hypergammaglobulinemia

MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

38
T Cells, B Cells, Tongue, Myeloid, Skin, Bone, Smooth Muscle

Publications for Polyclonal Hypergammaglobulinemia

Articles related to Polyclonal Hypergammaglobulinemia:

(show all 24)
# Title Authors Year
1
A Case of Lethal Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Medical Challenge for the Forensic Pathologist. ( 27364300 )
2016
2
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. ( 21316456 )
2011
3
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. ( 19008139 )
2009
4
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. ( 19586961 )
2009
5
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. ( 18336788 )
2008
6
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. ( 15802958 )
2005
7
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. ( 14765269 )
2004
8
Decreased anion gap in polyclonal hypergammaglobulinemia. ( 11937082 )
2002
9
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. ( 11399611 )
2000
10
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. ( 10550554 )
1999
11
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. ( 9786355 )
1998
12
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. ( 9185918 )
1997
13
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. ( 8589372 )
1995
14
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. ( 7812213 )
1994
15
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. ( 8432045 )
1993
16
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. ( 1633368 )
1992
17
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. ( 1650855 )
1991
18
[Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. ( 2386010 )
1990
19
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. ( 3318265 )
1987
20
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. ( 3777978 )
1986
21
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. ( 6464210 )
1984
22
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. ( 6230148 )
1984
23
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. ( 78444 )
1978
24
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. ( 4123735 )
1973

Variations for Polyclonal Hypergammaglobulinemia

Expression for Polyclonal Hypergammaglobulinemia

Search GEO for disease gene expression data for Polyclonal Hypergammaglobulinemia.

Pathways for Polyclonal Hypergammaglobulinemia

GO Terms for Polyclonal Hypergammaglobulinemia

Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CD2 CD4 CD40LG CD79A

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.33 CD2 CD4 CD79A
2 T cell activation GO:0042110 9.26 CD2 CD4
3 B cell proliferation GO:0042100 8.96 CD40LG CD79A
4 positive regulation of T cell proliferation GO:0042102 8.8 CD4 CD40LG IL6

Sources for Polyclonal Hypergammaglobulinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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