MCID: PLY010
MIFTS: 34

Polyclonal Hypergammaglobulinemia malady

Summaries for Polyclonal Hypergammaglobulinemia

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33MalaCards
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MalaCards: Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to colon lymphoma and acute myeloid leukemia. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Cytokines and Inflammatory Response and Th17 Differentiation. The compounds sandoglobulin and bucillamine have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and bone marrow, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt
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Aliases & Descriptions:

polyclonal hypergammaglobulinemia 8 10 45 61
polyclonal hypergammaglobulinemia nos 8


External Ids:

Disease Ontology8 DOID:2344
ICD9CM27 273.0
NCIt40 C35885

Related Diseases for Polyclonal Hypergammaglobulinemia

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17GeneCards, 18GeneDecks
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Diseases related to Polyclonal Hypergammaglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1colon lymphoma10.2
2acute myeloid leukemia10.2
3visceral leishmaniasis10.2
4autoimmune hepatitis10.2
5mantle cell lymphoma10.2
6n syndrome10.2
7acute leukemia10.2
8hepatitis a10.2
9arthritis10.2
10bone marrow necrosis10.2
11mass syndrome10.2
12primary malignant lymphoma10.2
13histiocytosis-lymphadenopathy plus syndrome10.2
14histiocytosis10.0SLC29A3
15paraneoplastic syndromes10.0IL6
16peripheral vascular disease10.0CD79A
17agammaglobulinemia10.0CD79A
18hairy cell leukemia10.0ITGAX
19bronchiectasis10.0CD79A
20human immunodeficiency virus infectious disease10.0CD79A
21bronchitis10.0CD79A
22polyneuropathy10.0CD79A
23lupus nephritis10.0CD79A
24exanthem10.0CD79A
25atherosclerosis10.0IL6
26proliferative glomerulonephritis10.0CD79A
27sjogren's syndrome10.0CD79A
28celiac disease10.0CD79A
29pemphigus foliaceus10.0CD79A
30nephritis10.0CD79A
31rhinitis10.0CD79A
32q fever10.0CD79A
33brucellosis10.0CD79A
34lupus erythematosus10.0CD79A
35pertussis10.0CD79A
36lymphatic system disease10.0CD4
37mycobacterium avium complex disease10.0CD4
38uveitis10.0CD4
39listeriosis10.0CD4
40leprosy10.0CD4
41alopecia10.0CD4
42lymphopenia10.0IL6
43reactive arthritis10.0CD79A
44myocarditis10.0CD4
45cryptococcosis10.0CD4
46histoplasmosis10.0CD4
47mesangial proliferative glomerulonephritis10.0IL6, CD79A
48sarcoidosis10.0CD4
49allergic rhinitis10.0CD4
50herpes zoster10.0CD4

Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to polyclonal hypergammaglobulinemia

Clinical Features for Polyclonal Hypergammaglobulinemia

Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Polyclonal Hypergammaglobulinemia

Drug clinical trials:

Search ClinicalTrials for Polyclonal Hypergammaglobulinemia

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Search CenterWatch for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

Anatomical Context for Polyclonal Hypergammaglobulinemia

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33MalaCards
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MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

33
Skin, Tongue, Bone marrow, Smooth muscle, Colon, Myeloid, T cells, B cells

Animal Models for Polyclonal Hypergammaglobulinemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Polyclonal Hypergammaglobulinemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.9CD4, CD79A, IL6, SLC29A3, ITGAX
2MP:00053977.6SLC29A3, IL6, CD79A, CD4, ITGAX

Publications for Polyclonal Hypergammaglobulinemia

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51PubMed
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Articles related to Polyclonal Hypergammaglobulinemia:

(show all 24)
idTitleAuthorsYear
1
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. (21316456)
2011
2
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. (19586961)
2009
3
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. (19008139)
2009
4
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. (18336788)
2008
5
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. (15802958)
2005
6
Polyclonal proliferation of plasma cells associated with marked hypergammaglobulinemia in an elderly patient. (15717691)
2005
7
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. (14765269)
2004
8
Decreased anion gap in polyclonal hypergammaglobulinemia. (11937082)
2002
9
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
10
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. (10550554)
1999
11
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. (9786355)
1998
12
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. (9185918)
1997
13
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. (8589372)
1995
14
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. (7812213)
1994
15
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. (8432045)
1993
16
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (1633368)
1992
17
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. (1650855)
1991
18
Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. (2386010)
1990
19
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. (3318265)
1987
20
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. (3777978)
1986
21
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. (6230148)
1984
22
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (6464210)
1984
23
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. (78444)
1978
24
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. (4123735)
1973

Genetic Variations for Polyclonal Hypergammaglobulinemia

Expression for genes affiliated with Polyclonal Hypergammaglobulinemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyclonal Hypergammaglobulinemia

Search GEO for disease gene expression data for Polyclonal Hypergammaglobulinemia.

Pathways for genes affiliated with Polyclonal Hypergammaglobulinemia

Sources:
38NCBI BioSystems Database, 53R&D Systems, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Polyclonal Hypergammaglobulinemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1sandoglobulin459.9IL6, CD79A
2bucillamine459.9IL6, CD79A
3adalimumab45 50 1111.8IL6, CD79A
4pmma459.8CD79A, IL6
5okt3459.8CD79A, IL6
6hemocyanin459.8CD79A, CD4
7dextran sulfate459.7IL6, CD4
8mannan459.7CD79A, CD4
9dipyridamole45 60 29 1112.7SLC29A3, CD79A
10ivig459.6CD79A, IL6
11rituximab45 50 1111.6IL6, CD79A
12neopterin459.4IL6, CD79A, CD4
13melphalan45 1110.3IL6, CD79A
14pge2459.0IL6, CD79A, CD4
15mannose458.9ITGAX, CD4, CD79A
16fibrinogen458.9IL6, CD79A, ITGAX

GO Terms for genes affiliated with Polyclonal Hypergammaglobulinemia

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16Gene Ontology
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Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.3IL6, CD79A, CD4, ITGAX

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.6IL6, CD4
2defense response to Gram-negative bacteriumGO:0508299.5IL6, CD4
3response to heatGO:0094089.2IL6, CRNN

Products for genes affiliated with Polyclonal Hypergammaglobulinemia

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  • Proteins
  • Lysates
  • Antibodies

Sources for Polyclonal Hypergammaglobulinemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet