MCID: PLY010
MIFTS: 34

Polyclonal Hypergammaglobulinemia malady

Categories: Immune diseases, Metabolic diseases

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

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Aliases & Descriptions for Polyclonal Hypergammaglobulinemia:

Name: Polyclonal Hypergammaglobulinemia 10 47 12 65
 
Polyclonal Hypergammaglobulinemia Nos 10

Classifications:



External Ids:

Disease Ontology10 DOID:2344
ICD1027 D89.0
ICD9CM29 273.0
NCIt42 C35885
UMLS65 C0154254

Summaries for Polyclonal Hypergammaglobulinemia

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MalaCards based summary: Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to blue toe syndrome and wrinkles. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (Interleukin 6), and among its related pathways are Malaria and Cytokines and Inflammatory Response. Affiliated tissues include t cells, spinal cord and lung.

Related Diseases for Polyclonal Hypergammaglobulinemia

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Diseases related to Polyclonal Hypergammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 225)
idRelated DiseaseScoreTop Affiliating Genes
1blue toe syndrome29.9CD40LG, CD79A, IL6
2wrinkles10.5CD40LG, IL6
3congenital dyserythropoietic anemia10.5CD40LG, IL6
4lemierre's syndrome10.5CD79A, SLC29A3
5plasmacytoma10.5CD79A, IL6
6hemorrhagic proctocolitis10.4CD40LG, IL6
7human granulocytic anaplasmosis10.4CD40LG, IL6
8typhus10.4CD40LG, CD79A
9pulmonary edema10.4CD40LG, CD79A
10congenital hypogammaglobulinemia10.4CD40LG, CD79A
11calabro syndrome10.4CD40LG, CD79A
12gamma heavy chain disease10.4CD40LG, CD79A
13exanthema subitum10.4CD40LG, CD79A
14osteomalacia10.4CD40LG, CD79A
15epidermolysis bullosa simplex10.4CD40LG, CD79A
16proliferative glomerulonephritis10.4CD40LG, CD79A
17cryopyrin-associated periodic syndrome10.4CD40LG, CD79A
18acute salpingitis10.4CD40LG, CD79A
19beriberi10.4CD40LG, CD79A
20cystitis10.4CD40LG, CD79A
21purpura10.4CD40LG, CD79A
22collagenous colitis10.4CD79A, IL6
23choroid plexus meningioma10.4CD40LG, CD79A
24immunotactoid glomerulopathy10.4CD40LG, CD79A
25subacute delirium10.4CD40LG, CD79A
26large intestine lipoma10.4CD40LG, IL6
27alpha chain disease10.4CD40LG, CD79A
28dysgammaglobulinemia10.4CD40LG, CD79A
29generalized atherosclerosis10.4CD40LG, CD79A
30central sleep apnea10.4CD40LG, CD79A
31sialadenitis10.4CD40LG, CD79A
32ureteral lymphoma10.4CD40LG, CD79A
33mixed lacrimal gland cancer10.4CD40LG, CD79A
34somatoform disorder10.4CD40LG, CD79A
35aids phobia10.4CD40LG, CD79A
36granulomatous amebic encephalitis10.4CD79A, IL6
37tenosynovitis10.4CD40LG, CD79A
38brucella melitensis brucellosis10.4CD40LG, CD79A
39fallopian tube carcinoma10.4CD40LG, CD79A
40maxillary sinusitis10.4CD40LG, CD79A
41peripheral nervous system disease10.4CD40LG, CD79A
42primary systemic mycosis10.4CD40LG, CD79A
43impaired renal function disease10.4CD40LG, CD79A
44parasitic conjunctivitis10.4CD40LG, CD79A
45skin granular cell tumor10.4CD40LG, CD79A
46spinocerebellar ataxia, autosomal recessive 1010.4CD40LG, CD79A
47weill-marchesani syndrome10.4CD40LG, CD79A
48vagus nerve neoplasm10.4CD40LG, IL6
49histiocytosis-lymphadenopathy plus syndrome10.4
50indolent myeloma10.4CD40LG, CD79A

Comorbidity relations with Polyclonal Hypergammaglobulinemia via Phenotypic Disease Network (PDN):


Deficiency AnemiaHeart Disease
Acute Cystitis

Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to polyclonal hypergammaglobulinemia

Symptoms for Polyclonal Hypergammaglobulinemia

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Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

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Drugs for Polyclonal Hypergammaglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunoglobulins4477
2Autoantibodies117
3Antibodies4477

Interventional clinical trials:

idNameStatusNCT IDPhase
1Auto-antibodies Prevalence and CD1 Role in Gaucher DiseaseCompletedNCT02650219

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

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Anatomical Context for Polyclonal Hypergammaglobulinemia

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MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

33
T cells, Spinal cord, Lung, Liver, Breast, B cells, Skin

Animal Models for Polyclonal Hypergammaglobulinemia or affiliated genes

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Publications for Polyclonal Hypergammaglobulinemia

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Articles related to Polyclonal Hypergammaglobulinemia:

(show all 23)
idTitleAuthorsYear
1
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. (21316456)
2011
2
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. (19586961)
2009
3
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. (19008139)
2009
4
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. (18336788)
2008
5
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. (15802958)
2005
6
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. (14765269)
2004
7
Decreased anion gap in polyclonal hypergammaglobulinemia. (11937082)
2002
8
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
9
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. (10550554)
1999
10
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. (9786355)
1998
11
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. (9185918)
1997
12
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. (8589372)
1995
13
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. (7812213)
1994
14
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. (8432045)
1993
15
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (1633368)
1992
16
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. (1650855)
1991
17
Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. (2386010)
1990
18
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. (3318265)
1987
19
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. (3777978)
1986
20
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. (6230148)
1984
21
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. (6464210)
1984
22
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. (78444)
1978
23
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. (4123735)
1973

Variations for Polyclonal Hypergammaglobulinemia

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Expression for genes affiliated with Polyclonal Hypergammaglobulinemia

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Search GEO for disease gene expression data for Polyclonal Hypergammaglobulinemia.

Pathways for genes affiliated with Polyclonal Hypergammaglobulinemia

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GO Terms for genes affiliated with Polyclonal Hypergammaglobulinemia

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Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1defense response to Gram-negative bacteriumGO:00508299.5CD4, IL6
2T cell activationGO:00421109.5CD4, IL6
3T cell costimulationGO:00312959.5CD4, CD40LG

Sources for Polyclonal Hypergammaglobulinemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet