MCID: PLY010
MIFTS: 30

Polyclonal Hypergammaglobulinemia malady

Categories: Immune diseases, Metabolic diseases

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

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Aliases & Descriptions for Polyclonal Hypergammaglobulinemia:

Name: Polyclonal Hypergammaglobulinemia 10 47 12 65
 
Polyclonal Hypergammaglobulinemia Nos 10

Classifications:



External Ids:

Disease Ontology10 DOID:2344
ICD1027 D89.0
ICD9CM29 273.0
NCIt42 C35885
UMLS65 C0154254

Summaries for Polyclonal Hypergammaglobulinemia

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MalaCards based summary: Polyclonal Hypergammaglobulinemia, also known as polyclonal hypergammaglobulinemia nos, is related to systemic lupus erythematosus and histiocytosis-lymphadenopathy plus syndrome. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (Interleukin 6), and among its related pathways are Malaria and Cytokines and Inflammatory Response. Affiliated tissues include breast, adipocyte and liver.

Related Diseases for Polyclonal Hypergammaglobulinemia

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Diseases related to Polyclonal Hypergammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus29.6CD40LG, CD79A, IL6, SNRPB
2histiocytosis-lymphadenopathy plus syndrome10.8
3wrinkles10.3CD40LG, IL6
4congenital dyserythropoietic anemia10.3CD40LG, IL6
5lemierre's syndrome10.3CD79A, SLC29A3
6plasmacytoma10.3CD79A, IL6
7hemorrhagic proctocolitis10.3CD40LG, IL6
8human granulocytic anaplasmosis10.3CD40LG, IL6
9typhus10.3CD40LG, CD79A
10pulmonary edema10.3CD40LG, CD79A
11congenital hypogammaglobulinemia10.3CD40LG, CD79A
12calabro syndrome10.3CD40LG, CD79A
13gamma heavy chain disease10.3CD40LG, CD79A
14exanthema subitum10.3CD40LG, CD79A
15osteomalacia10.3CD40LG, CD79A
16epidermolysis bullosa simplex10.3CD40LG, CD79A
17proliferative glomerulonephritis10.3CD40LG, CD79A
18cryopyrin-associated periodic syndrome10.3CD40LG, CD79A
19acute salpingitis10.3CD40LG, CD79A
20beriberi10.3CD40LG, CD79A
21cystitis10.3CD40LG, CD79A
22purpura10.3CD40LG, CD79A
23collagenous colitis10.3CD79A, IL6
24choroid plexus meningioma10.3CD40LG, CD79A
25immunotactoid glomerulopathy10.3CD40LG, CD79A
26subacute delirium10.3CD40LG, CD79A
27large intestine lipoma10.3CD40LG, IL6
28alpha chain disease10.3CD40LG, CD79A
29dysgammaglobulinemia10.3CD40LG, CD79A
30generalized atherosclerosis10.3CD40LG, CD79A
31central sleep apnea10.3CD40LG, CD79A
32sialadenitis10.3CD40LG, CD79A
33ureteral lymphoma10.3CD40LG, CD79A
34mixed lacrimal gland cancer10.3CD40LG, CD79A
35somatoform disorder10.3CD40LG, CD79A
36aids phobia10.3CD40LG, CD79A
37granulomatous amebic encephalitis10.3CD79A, IL6
38tenosynovitis10.3CD40LG, CD79A
39brucella melitensis brucellosis10.3CD40LG, CD79A
40fallopian tube carcinoma10.3CD40LG, CD79A
41maxillary sinusitis10.3CD40LG, CD79A
42peripheral nervous system disease10.3CD40LG, CD79A
43primary systemic mycosis10.3CD40LG, CD79A
44impaired renal function disease10.3CD40LG, CD79A
45parasitic conjunctivitis10.3CD40LG, CD79A
46skin granular cell tumor10.3CD40LG, CD79A
47spinocerebellar ataxia, autosomal recessive 1010.3CD40LG, CD79A
48weill-marchesani syndrome10.3CD40LG, CD79A
49vagus nerve neoplasm10.3CD40LG, IL6
50indolent myeloma10.3CD40LG, CD79A

Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to polyclonal hypergammaglobulinemia

Symptoms for Polyclonal Hypergammaglobulinemia

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Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

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Drugs for Polyclonal Hypergammaglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunoglobulins4477
2Autoantibodies117
3Antibodies4477

Interventional clinical trials:

idNameStatusNCT IDPhase
1Auto-antibodies Prevalence and CD1 Role in Gaucher DiseaseCompletedNCT02650219

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

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Anatomical Context for Polyclonal Hypergammaglobulinemia

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MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

33
Breast, Adipocyte, Liver, Lung, T cells, Myeloid

Animal Models for Polyclonal Hypergammaglobulinemia or affiliated genes

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Publications for Polyclonal Hypergammaglobulinemia

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Articles related to Polyclonal Hypergammaglobulinemia:

(show all 23)
idTitleAuthorsYear
1
Induction of Protective Immune Responses Against Schistosomiasis haematobium in Hamsters and Mice Using Cysteine Peptidase-Based Vaccine. (25852696)
2015
2
Association between VDR polymorphisms and breast cancer: an updated and comparative meta-analysis of crude and adjusted odd ratios. (24568506)
2014
3
Loss of chromosomes is the primary event in near-haploid and low-hypodiploid acute lymphoblastic leukemia. (22889820)
2013
4
Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors. (23889474)
2013
5
Nanog, a novel prognostic marker for lung cancer. (24018162)
2013
6
A two-step screening algorithm including fasting plasma glucose measurement and a risk estimation model is an accurate strategy for detecting gestational diabetes mellitus. (23001377)
2012
7
PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib. (21676217)
2011
8
Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells. (20683915)
2011
9
Dystrophin gene mutation location and the risk of cognitive impairment in Duchenne muscular dystrophy. (20098710)
2010
10
IL-15 regulates both quantitative and qualitative features of the memory CD8 T cell pool. (19949092)
2010
11
Invasive aspergillosis in two liver transplant recipients: diagnosis by SeptiFast. (19210691)
2009
12
Long-term culture of Japanese human embryonic stem cells in feeder-free conditions. (18468232)
2008
13
Recurrent KIND1 (C20orf42) gene mutation, c.676insC, in a Brazilian pedigree with Kindler syndrome. (17916195)
2007
14
Basaloid squamous cell carcinoma of the sinonasal tract: report of two cases. (16647553)
2006
15
Dearth of glutamate transporters contributes to striatal excitotoxicity. (15380474)
2004
16
Effect of epidermal growth factor on phosphate uptake in renal proximal tubule cells: involvement of PKC, MAPK, and cPLA2. (14610335)
2003
17
Expression of protooncogene c-kit and its ligand stem cell factor (SCF) in gastric carcinoma cell lines. (9508539)
1998
18
Cisplatin but not BCNU inhibits urokinase-type plasminogen activator levels in human glioblastoma cell lines in vitro. (9219734)
1997
19
Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity. (9174661)
1997
20
Transcriptional regulation of gene expression during adipocyte differentiation. (7574486)
1995
21
Opioid agonists modulate release of neurotransmitters in bovine trachealis muscle. (7661355)
1995
22
EVI1 expression associated with a 3q26 anomaly in a leukemia cell line derived from the blast crisis of chronic myeloid leukemia. (7808006)
1994
23
Relationship between pH of intravenous medications and phlebitis: an experimental study. (6922413)
1982

Variations for Polyclonal Hypergammaglobulinemia

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Expression for genes affiliated with Polyclonal Hypergammaglobulinemia

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Search GEO for disease gene expression data for Polyclonal Hypergammaglobulinemia.

Pathways for genes affiliated with Polyclonal Hypergammaglobulinemia

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GO Terms for genes affiliated with Polyclonal Hypergammaglobulinemia

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Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1defense response to Gram-negative bacteriumGO:00508299.5CD4, IL6
2T cell activationGO:00421109.5CD4, IL6
3T cell costimulationGO:00312959.5CD4, CD40LG

Sources for Polyclonal Hypergammaglobulinemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet