Polycystic Kidney Disease, Autosomal Dominant malady

Wikipedia: Autosomal dominant polycystic kidney disease (\"ADPKD\", \"autosomal dominant PKD\" or \"Adult-onset...⁴⁴ more...

MalaCards: Polycystic Kidney Disease, Autosomal Dominant, also known as ADPKD, is related to polycystic kidney disease, autosomal recessive and polycystic kidney disease. An important gene associated with Polycystic Kidney Disease, Autosomal Dominant is PKD2 (polycystic kidney disease 2 (autosomal dominant)), and among its related pathways is Calcium channels. The compounds sodium and trp-p-2 have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and liver.

GeneReviews summary for pkd-ad

polycystic kidney disease, autosomal dominant 15 16 adpkd 15 16 32

polycystic kidney, autosomal dominant 43 polycystic kidney diseases 43

Disease types for polycystic kidney disease, autosomal dominant family:

polycystic kidney disease 1, autosomal dominant	polycystic kidney disease 2, autosomal dominant

Diseases related to polycystic kidney disease, autosomal dominant by text searches and GeneDecks gene sharing:

(show top 50)    (show all 51)

id	Related Disease	Score	Top Affiliating Genes
1	polycystic kidney disease, autosomal recessive	33.3	PKD1, PKD2
2	polycystic kidney disease	33.1	PKD2, PKD1
3	polycystic kidney disease 2, autosomal dominant	31.6	PKD1, PKD2
4	polycystic liver disease	30.7	PKD2, PKD1
5	nephronophthisis	29.9	PKD2, PKD1
6	cystic kidney	28.3	PKD1, PKD2
7	retinal degeneration	28.2	PKD1, PKD2
8	auditory system disease	12.4	PKD1, PKD2
9	autosomal dominant disease	12.4	PKD2, PKD1
10	aneurysm disease	12.3	PKD2, PKD1
11	intracranial aneurysm	12.3	PKD1, PKD2
12	primary hyperoxaluria	12.2	PKD2, PKD1
13	chronic kidney failure	12.1	PKD1, PKD2
14	mayer-rokitansky-kuster-hauser syndrome	12.1	PKD1, PKD2
15	gout	11.8	PKD1, PKD2
16	polycystic kidney disease 2	9.9
17	kidney disease	9.8
18	tuberous sclerosis	9.1
19	nephropathy	8.7
20	polycystic kidney disease 1, autosomal dominant	8.6
21	cystic fibrosis	8.4
22	fibrosis	8.4
23	oral-facial-digital syndrome type i	8.0
24	polycystic kidneys, severe infantile with tuberous sclerosis	8.0
25	polycystic kidney disease, adult type i	8.0
26	potter's syndrome	7.7
27	aldosteronism	7.5
28	diabetes mellitus	7.5
29	liver disease	7.5
30	orofaciodigital syndrome	7.5
31	retinitis	7.5
32	aortic aneurysm	6.6
33	thrombosis	6.6
34	bronchiectasis	6.6
35	type 2 diabetes mellitus	6.6
36	cleft lip	6.6
37	cleft lip/palate	6.6
38	erythrocytosis	6.6
39	hearing loss	6.6
40	hypoxia	6.6
41	joubert syndrome	6.6
42	marfan syndrome	6.6
43	oral-facial-digital syndrome	6.6
44	polycystic kidney and hepatic disease	6.6
45	pancreatitis	6.6
46	potter syndrome type 1	6.6
47	abdominal aortic aneurysm	6.6
48	amelogenesis imperfecta	6.6
49	tuberous sclerosis, type 2	6.6
50	hepatitis	5.7

Approved drugs:

Drug clinical trials:

Genetic tests related to polycystic kidney disease, autosomal dominant:

id	Genetic test	Affiliating Genes
1	Polycystic Kidney Disease, Autosomal Dominant clinical/research	PKD1, PKD2

MalaCards organs/tissues related to polycystic kidney disease, autosomal dominant:

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Genes related to polycystic kidney disease, autosomal dominant according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PKD2	polycystic kidney disease 2 (autosomal dominant)	11.0
2	PKD1	polycystic kidney disease 1 (autosomal dominant)	11.0

Pathways related to polycystic kidney disease, autosomal dominant according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Calcium channels10	9.1	PKD1, PKD2

Compounds related to polycystic kidney disease, autosomal dominant according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	sodium32 18	10.1	PKD1, PKD2
2	trp-p-232	9.0	PKD1, PKD2
3	polyacrylamide32	8.8	PKD1, PKD2

Cellular components related to polycystic kidney disease, autosomal dominant according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cilium	GO:005929	9.1	PKD1, PKD2
2	polycystin complex	GO:002133	9.0	PKD1, PKD2
3	motile primary cilium	GO:031512	8.8	PKD1, PKD2

Biological processes related to polycystic kidney disease, autosomal dominant according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	mesonephric tubule development	GO:072164	9.4	PKD2, PKD1
2	metanephric ascending thin limb development	GO:072218	9.4	PKD2, PKD1
3	mesonephric duct development	GO:072177	9.4	PKD2, PKD1
4	detection of mechanical stimulus	GO:050982	9.4	PKD1, PKD2
5	placenta blood vessel development	GO:060674	9.4	PKD1, PKD2
6	positive regulation of cyclin-dependent protein kinase activity involved in G1/S	GO:031659	9.3	PKD1, PKD2
7	cytoplasmic sequestering of transcription factor	GO:042994	9.3	PKD2, PKD1
8	neural tube development	GO:021915	9.3	PKD2, PKD1
9	spinal cord development	GO:021510	9.2	PKD2, PKD1
10	embryonic placenta development	GO:001892	9.2	PKD2, PKD1
11	JAK-STAT cascade	GO:007259	9.1	PKD2, PKD1
12	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.1	PKD2, PKD1
13	heart development	GO:007507	9.0	PKD2, PKD1
14	cell cycle arrest	GO:007050	8.8	PKD2, PKD1

Molecular functions related to polycystic kidney disease, autosomal dominant according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ion channel binding	GO:044325	9.1	PKD1, PKD2