PCOS
MCID: PLY011
MIFTS: 66

Polycystic Ovary Syndrome (PCOS) malady

Endocrine category

Summaries for Polycystic Ovary Syndrome

Sources:
43NIH Rare Diseases, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Polycystic ovary syndrome (pcos) happens when a woman's ovaries or adrenal glands produce more male hormones than normal. one result is that cysts (fluid-filled sacs) develop on the ovaries. women who are obese are more likely to have polycystic ovary syndrome. symptoms of pcos include: infertility pelvic pain excess hair growth on the face, chest, stomach, thumbs, or toes baldness or thinning hair acne, oily skin, or dandruff patches of thickened dark brown or black skin women with pcos are at higher risk of diabetes, metabolic syndrome, heart disease, and high blood pressure. medicines can help control the symptoms. birth control pills help women have normal periods, reduce male hormone levels, and clear acne. other medicines can reduce hair growth and control blood pressure and cholesterol. there is no cure. nih: national institute of child health and human development

MalaCards: Polycystic Ovary Syndrome, also known as polycystic ovaries, is related to insulin resistance and hyperandrogenism. An important gene associated with Polycystic Ovary Syndrome is SULT2A1 (sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1), and among its related pathways are Ovarian steroidogenesis and Adipogenesis. The drug urofollitropin and the compounds testosterone and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

NIH Rare Diseases:43 Polycystic ovarian syndrome (pcos) is a health problem that can affect a woman's menstrual cycle, ability to have children, hormones, heart, blood vessels, and appearance. women with this condition typically have high levels of  hormones called androgens, missed or irregular periods, and many small cysts in their ovaries. the cause of pcos is unknown, but probably involves a combination of genetic and environmental factors. treatment for pcos may involve birth control pills and medications for diabetes and infertility. medicines called anti-androgens are also used to speed the growth of hair and clear acne. last updated: 11/10/2008

Wikipedia:64 Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among females. PCOS is a... more...

Description from OMIM:47 184700

Aliases & Classifications for Polycystic Ovary Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 47OMIM, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

polycystic ovary syndrome 8 10 45 34 61
polycystic ovaries 8 45
pcos 8 43
polycystic ovarian syndrome 43
polycystic ovarian disease 8
stein-leventhal syndrome 8
stein-leventhal synd. 8
multicystic ovaries 8
polycystic ovary 8


External Ids:

Disease Ontology8 DOID:11612
NCIt40 C26862
OMIM47 184700
ICD9CM27 256.4
MeSH35 D011085
ICD1025 E28.2

Related Diseases for Polycystic Ovary Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Polycystic Ovary Syndrome family:

polycystic ovary syndrome 1

Diseases related to Polycystic Ovary Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 265)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.9CAPN10, LSL, RBP4, GHRL, SHBG, IGFBP1
2hyperandrogenism31.6SHBG, IGFBP1, CYP17A1, CYP11A1, RETN, INS
3anovulation31.1IGFBP1, INS, LEP, SULT2A1, SHBG, GHRL
4infertility31.1LSL, GNRH1, BMP15, SHBG, IGFBP1, CYP11A1
5glucose intolerance31.1CAPN10, LSL, RBP4, GHRL, SHBG, IGFBP1
6hyperinsulinism30.9LSL, GNRH1, GHRL, SHBG, IGFBP1, RETN
7acanthosis nigricans30.9SHBG, INS, LEP, ADIPOQ
8gestational diabetes30.9LSL, RBP4, SHBG, IGFBP1, RETN, NAMPT
9ovarian hyperstimulation syndrome30.9GNRH1
10premature ovarian failure30.8GNRH1, BMP15, SHBG, CYP11A1, GDF9
11amenorrhea30.8AMH, GNRH1, BMP15, SHBG, INS, LEP
12atherosclerosis30.7CAPN10, LSL, RBP4, GHRL, SHBG, RETN
13precocious puberty30.6AMH, LSL, GNRH1, SHBG, LEP
14hyperprolactinemia30.6SHBG, GNRH1
15acne30.6SHBG
16fatty liver disease30.5RBP4, CYP17A1, RETN, INS, LEP, ADIPOQ
17cushing's syndrome30.4INS, SULT2A1
18adrenal adenoma30.4CYP17A1, CYP11A1, SULT2A1
19adenoma30.4GNRH1, GHRL, SHBG, IGFBP1, CYP17A1, CYP11A1
20coronary heart disease30.4AMH, SHBG, RETN, INS, LEP, ADIPOQ
21coronary artery disease,30.4GHRL, IGFBP1, RETN, NAMPT, INS, ADIPOQ
22congenital adrenal hyperplasia30.4CYP11A1, CYP17A1, GNRH1, LSL
23vascular disease30.4ADIPOQ, INS, NAMPT, RETN
24graves' disease30.4SHBG
25pituitary tumors30.4FST, GHRL, GNRH1
26conn's syndrome30.4CYP11A1, CYP17A1
27turner syndrome30.3IGFBP1, SHBG, BMP15
28acromegaly30.2ADIPOQ, LSL, GNRH1, GHRL, SHBG, IGFBP1
29morbid obesity30.2LSL, GHRL, RETN, INS, LEP, ADIPOQ
30anorexia nervosa30.2LSL, GHRL, SHBG, IGFBP1, RETN, LEP
31adenocarcinoma30.2IGFBP1, GHRL
32down syndrome30.2FST
33prolactinoma30.2GNRH1
34klinefelter's syndrome30.2SHBG, GNRH1
35congenital generalized lipodystrophy type 230.0LSL, INS, LEP, ADIPOQ
36rabson-mendenhall syndrome30.0INS
37hypoglycemia29.9INS, IGFBP1, GHRL, GNRH1, LSL
38hypercholesterolemia29.9CAPN10, RBP4, RETN, INS, ADIPOQ
39n syndrome11.3
40young syndrome10.9
41bod syndrome10.9
42char syndrome10.9
43mass syndrome10.9
44polycystic ovary syndrome 110.8
45micro syndrome10.7
46adult syndrome10.6
47short syndrome10.5
48lip disease10.5
49fowler's syndrome10.4
50west syndrome10.4

Graphical network of the top 20 diseases related to Polycystic Ovary Syndrome:



Diseases related to polycystic ovary syndrome

Clinical Features for Polycystic Ovary Syndrome

Sources:
47OMIM
See all sources

Clinical features from OMIM:

184700

Drugs & Therapeutics for Polycystic Ovary Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Polycystic Ovary Syndrome

Drug clinical trials:

Search ClinicalTrials for Polycystic Ovary Syndrome

Search NIH Clinical Center for Polycystic Ovary Syndrome

Search CenterWatch for Polycystic Ovary Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Polycystic Ovary Syndrome

Anatomical Context for Polycystic Ovary Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Polycystic Ovary Syndrome:

33
Whole blood, Brain, Cortex, Heart, Skeletal muscle, Adipocyte, Kidney, Liver, Pancreas, Thyroid, Adrenal gland, Breast, Skin, Ovary, Placenta, Prostate, Monocytes, T cells, B cells, Endothelial, Fetal brain, Tongue, Fetal liver, Fetal thyroid, Adrenal cortex, Pituitary

Animal Models for Polycystic Ovary Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Polycystic Ovary Syndrome

Sources:
51PubMed
See all sources

Articles related to Polycystic Ovary Syndrome:

(show top 50)    (show all 1952)
idTitleAuthorsYear
1
Leptin levels and adipose tissue percentage in adolescents with polycystic ovary syndrome. (23350621)
2013
2
Diet, physical exercise and Orlistat administration increase serum anti-MA1llerian hormone (AMH) levels in women with polycystic ovary syndrome (PCOS). (23194076)
2013
3
Alterations in thyroid function among the different polycystic ovary syndrome phenotypes. (23957782)
2013
4
Effects of tanshinone on hyperandrogenism and the quality of life in women with polycystic ovary syndrome: protocol of a double-blind, placebo-controlled, randomised trial. (24163207)
2013
5
Tear osmolarity and ocular surface changes in patient with polycystic ovary syndrome. (23249394)
2013
6
NIH panel: Name change, new priorities advised for polycystic ovary syndrome. (23462765)
2013
7
Proteomic and metabolomic approaches to the study of polycystic ovary syndrome. (23422073)
2013
8
Sex hormone binding globulin, but not testosterone, is associated with the metabolic syndrome in overweight and obese women with polycystic ovary syndrome. (23812344)
2013
9
Association of polycystic ovary syndrome susceptibility single nucleotide polymorphism rs2479106 and PCOS in Caucasian patients with PCOS or hirsutism as referral diagnosis. (22504079)
2012
10
Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase gene mutations in iranian women with polycystic ovary syndrome. (22882325)
2012
11
Weight loss significantly reduces serum lipocalin-2 levels in overweight and obese women with polycystic ovary syndrome. (21756081)
2012
12
Polycystic ovary syndrome - an update. (23210095)
2012
13
Serum lipocalin-2 as an insulin resistance marker in patients with polycystic ovary syndrome. (20511727)
2011
14
Effect of metformin on serum visfatin levels in patients with polycystic ovary syndrome. (19111298)
2010
15
Heart rate recovery improves after weight loss in overweight and obese women with polycystic ovary syndrome. (19147136)
2010
16
Effect of sibutramine on weight reduction and insulin resistance in women with polycystic ovary syndrome. (19362719)
2009
17
Correlates of increased lean muscle mass in women with polycystic ovary syndrome. (19605540)
2009
18
Increased clearance of cortisol by 5beta-reductase in a subgroup of women with adrenal hyperandrogenism in polycystic ovary syndrome. (19542736)
2009
19
Plasminogen activator inhibitor-1 4G/5G and 5,10-methylene-tetrahydrofolate reductase C677T polymorphisms in polycystic ovary syndrome. (19066200)
2009
20
Comparative effects of atorvastatin and simvastatin on the plasma total homocysteine levels in women with polycystic ovary syndrome: a prospective randomized study. (18692805)
2009
21
Androgen receptor gene CAG(n) trinucleotide repeats polymorphism in Chinese women with polycystic ovary syndrome. (18483883)
2008
22
Granulosa cell survival and proliferation are altered in polycystic ovary syndrome. (18073308)
2008
23
Insulin sensitivity after metformin suspension in normal-weight women with polycystic ovary syndrome. (17519312)
2007
24
Triggering final oocyte maturation using different doses of human chorionic gonadotropin: a randomized pilot study in patients with polycystic ovary syndrome treated with gonadotropin-releasing hormone antagonists and recombinant follicle-stimulating hormone. (17445806)
2007
25
Is the polycystic ovary syndrome associated with chronic inflammation per se? (17224231)
2007
26
Indices of insulin sensitivity, beta cell function and serum proinsulin levels in the polycystic ovary syndrome. (16460870)
2006
27
Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin. (16497699)
2006
28
Decreased soluble leptin receptor levels in women with polycystic ovary syndrome. (16452543)
2006
29
Sustainability of 8% weight loss, reduction of insulin resistance, and amelioration of atherogenic-metabolic risk factors over 4 years by metformin-diet in women with polycystic ovary syndrome. (17142128)
2006
30
Luteinizing hormone secretion is not influenced by insulin infusion in women with polycystic ovary syndrome despite improved insulin sensitivity during pioglitazone treatment. (15644405)
2005
31
Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls. (16037106)
2005
32
Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome. (15063962)
2004
33
Metformin therapy in women with polycystic ovary syndrome. (15548396)
2004
34
Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome. (14644808)
2003
35
Serum leptin levels in normal-weight and overweight women with polycystic ovary syndrome. (14664414)
2003
36
Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition. (15023670)
2003
37
The benefits of finasteride for hirsute women with polycystic ovary syndrome or idiopathic hirsutism. (12724020)
2003
38
Molecular progress in infertility: polycystic ovary syndrome. (12215335)
2002
39
Effect of insulin in polycystic ovary syndrome]. (12661468)
2002
40
Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome. (12213887)
2002
41
Ovarian and adrenal function in polycystic ovary syndrome. (10352919)
1999
42
The significance of polycystic-appearing ovaries versus normal-appearing ovaries in patients with polycystic ovary syndrome. (9093185)
1997
43
Serum androgen changes during meal-induced hyperinsulinemia and after acute sequential blockade and hyperstimulation of insulin release in women with polycystic ovary syndrome. (8845652)
1995
44
Evidence that an altered prolactin release is consequent to abnormal ovarian activity in polycystic ovary syndrome. (7589658)
1995
45
The effects of gonadotrophin-releasing hormone agonist on follicular development in patients with polycystic ovary syndrome in an in-vitro fertilization and embryo transfer programme. (7836506)
1994
46
Absence of insulin receptor gene mutations in three insulin-resistant women with the polycystic ovary syndrome. (7990713)
1994
47
Correlation between hormonal and metabolic profiles in women with polycystic ovary syndrome]. (1495451)
1992
48
Effects of the somatostatin analogue, octreotide, in polycystic ovary syndrome. (1518438)
1992
49
Induction of ovulation with pulsatile subcutaneous administration of human menopausal gonadotropin in patients with polycystic ovary syndrome. (2128881)
1990
50
Suppression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndrome. (2106527)
1990

Genetic Variations for Polycystic Ovary Syndrome

Expression for genes affiliated with Polycystic Ovary Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Polycystic Ovary Syndrome

Search GEO for disease gene expression data for Polycystic Ovary Syndrome.

Pathways for genes affiliated with Polycystic Ovary Syndrome

Sources:
30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore, 54Reactome
See all sources

Compounds for genes affiliated with Polycystic Ovary Syndrome

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1testosterone45 60 11 2415.4GHRL, ADIPOQ, SULT2A1, SHBG, IGFBP1, CYP17A1
2cholesterol45 29 11 2415.3SULT2A1, LEP, INS, NAMPT, RETN, CYP11A1
3lipid4512.3GHRL, SHBG, RETN, IGFBP1, CYP17A1, NAMPT
4progesterone45 60 29 11 2416.2AMH, FST, SULT2A1, LEP, RETN, BMP15
5creatinine4512.1LSL, GNRH1, RBP4, GHRL, NAMPT, SHBG
6metformin45 50 1114.1CYP17A1, SHBG, GHRL, CYP11A1, RETN, NAMPT
7dexamethasone45 50 29 1115.1FST, INS, NAMPT, RETN, CYP11A1, CYP17A1
8dhea4512.0CYP11A1, ADIPOQ, SULT2A1, LEP, INS, RETN
9rosiglitazone45 50 29 11 2416.0CYP17A1, RETN, NAMPT, INS, LEP, ADIPOQ
10androstenedione45 2413.0LSL, GNRH1, RBP4, SHBG, IGFBP1, CYP17A1
11steroid4511.9SHBG, IGFBP1, RBP4, GNRH1, CYP17A1, LEP
12thyroxine45 2412.9LSL, GNRH1, ADIPOQ, LEP, INS, RETN
13pioglitazone45 50 29 1114.9SHBG, IGFBP1, CYP17A1, RETN, NAMPT, INS
14acth4511.8SULT2A1, FST, LEP, CYP11A1, IGFBP1, GHRL
15arginine4511.8CYP17A1, ADIPOQ, LEP, INS, SHBG, GHRL
16ribonucleic acid4511.8FST, CYP17A1, NAMPT, GDF9, GNRH1, RBP4
17fatty acid4511.7GHRL, IGFBP1, RETN, INS, ADIPOQ, NAMPT
18lactate4511.7FST, IGFBP1, GNRH1, GHRL, LSL, SHBG
19c-peptide4511.7SHBG, GHRL, IGFBP1, RETN, LEP, ADIPOQ
20estrone45 29 11 2414.7ADIPOQ, IGFBP1, CYP17A1, LSL, GNRH1, SHBG
21dihydrotestosterone45 29 11 2414.7IGFBP1, SHBG, GNRH1, CYP17A1, CYP11A1, LEP
22estradiol45 11 2413.6AMH, GNRH1, SHBG, CYP17A1, CYP11A1, FST
23dehydroepiandrosterone sulfate4511.6GNRH1, RBP4, SHBG, IGFBP1, CYP11A1, SULT2A1
24gnrh4511.6GNRH1, GHRL, CYP11A1, CYP17A1, IGFBP1, SHBG
25tamoxifen45 50 29 1114.6LSL, GNRH1, SHBG, IGFBP1, SULT2A1, AMH
2617-hydroxyprogesterone45 2412.6GNRH1, ADIPOQ, RETN, CYP11A1, CYP17A1, IGFBP1
27triiodothyronine4511.6GHRL, SULT2A1, LEP, IGFBP1, SHBG, RBP4
28carbohydrates4511.5ADIPOQ, LEP, INS, IGFBP1, GHRL, LSL
29vitamin a45 11 2413.4CYP17A1, FST, ADIPOQ, RETN, LEP, IGFBP1
30octreotide45 60 29 1114.4LSL, GNRH1, IGFBP1, INS, ADIPOQ, GHRL
31triacylglycerol4511.4LSL, LEP, RBP4, GHRL, INS, ADIPOQ
32epinephrine45 11 2413.4INS, LEP, SHBG, LSL, GNRH1, GHRL
33progestin4511.4CYP11A1, GNRH1, SHBG, IGFBP1, ADIPOQ, CYP17A1
34glucose4511.3NAMPT, LSL, GHRL, FST, RBP4
35acipimox45 2912.3GHRL, INS, LSL, LEP, ADIPOQ
36nash4511.3INS, LEP, RETN, LSL, ADIPOQ
37corticosterone45 60 2413.3IGFBP1, GHRL, CYP11A1, LEP, LSL, CYP17A1
38orlistat45 60 1113.3LEP, ADIPOQ, LSL, INS, GHRL
39p0024511.3RBP4, LSL, IGFBP1, RETN, LEP, ADIPOQ
40thiazolidinedione4511.3LEP, RETN, INS, CYP17A1, ADIPOQ
41hydrocortisone45 2 60 1114.2ADIPOQ, LSL, INS, GHRL, IGFBP1, SHBG
4211beta-hydroxysteroid4511.2RETN, ADIPOQ, LEP, CYP11A1, CYP17A1
43alanine4511.2LSL, RBP4, ADIPOQ, SHBG, RETN, INS
44nifedipine45 50 29 1114.1CYP17A1, GHRL, GNRH1, ADIPOQ, LEP, CYP11A1
45valproate4511.1SHBG, IGFBP1, LSL, CYP17A1, CYP11A1
46norepinephrine45 11 2413.1RETN, GNRH1
47sibutramine45 1112.0INS, LEP, LSL, ADIPOQ
48beta-hydroxybutyrate4510.9INS, LEP, IGFBP1, LSL
49olanzapine50 45 29 11 2414.9LEP, ADIPOQ, INS, GHRL, LSL
50fibrinogen4510.9RETN, ADIPOQ, LEP, IGFBP1, INS, NAMPT

GO Terms for genes affiliated with Polycystic Ovary Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.5ADIPOQ, AMH, GNRH1, BMP15, RBP4, GHRL
2extracellular regionGO:00557611.3GHRL, RBP4, GNRH1, AMH, SHBG, IGFBP1
3secretory granule lumenGO:03477410.7INS, GHRL

Biological processes related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1glucose metabolic processGO:00600611.2ADIPOQ, LEP, INS, GHRL
2positive regulation of glucose importGO:04632611.1ADIPOQ, INS, CAPN10
3positive regulation of insulin secretionGO:03202411.1CAPN10, RBP4, GHRL
4cell-cell signalingGO:00726711.1AMH, GNRH1, NAMPT, INS
5response to insulin stimulusGO:03286811.1LEP, RETN, RBP4
6steroid metabolic processGO:00820211.0SULT2A1, CYP11A1, CYP17A1
7response to fungicideGO:06099211.0CYP17A1, CYP11A1
8dibenzo-p-dioxin metabolic processGO:01889411.0CYP17A1, CYP11A1
9biphenyl metabolic processGO:01887911.0CYP17A1, CYP11A1
10response to insecticideGO:01708511.0CYP17A1, CYP11A1
11phthalate metabolic processGO:01896311.0CYP17A1, CYP11A1
12phenol-containing compound metabolic processGO:01895811.0CYP17A1, CYP11A1
13response to ethanolGO:04547111.0ADIPOQ, RBP4, GNRH1
14positive regulation of insulin receptor signaling pathwayGO:04662810.9INS, LEP
15glucose homeostasisGO:04259310.9RBP4, INS, ADIPOQ
16negative regulation of gluconeogenesisGO:04572110.9ADIPOQ, INS
17cellular response to antibioticGO:07123610.9CYP11A1, CYP17A1
18adult feeding behaviorGO:00834310.8LEP, GHRL
19response to vitamin EGO:03319710.7LEP, CYP11A1
20Leydig cell differentiationGO:03332710.7CYP17A1, CYP11A1
21sterol metabolic processGO:01612510.7CYP11A1, CYP17A1
22positive regulation of cellular protein metabolic processGO:03227010.6INS, ADIPOQ
23sex differentiationGO:00754810.4CYP17A1, AMH

Molecular functions related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517911.0ADIPOQ, LEP, INS, RETN, GNRH1, AMH
2cytokine activityGO:00512510.9ADIPOQ, NAMPT, GDF9, BMP15
3growth factor activityGO:00808310.6AMH, BMP15, GDF9, LEP

Products for genes affiliated with Polycystic Ovary Syndrome

  • Antibodies
  • Proteins
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  • Antibodies

Sources for Polycystic Ovary Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet