PCOS
MCID: PLY011
MIFTS: 66

Polycystic Ovary Syndrome (PCOS) malady

Rare diseases, Endocrine diseases categories

Summaries for Polycystic Ovary Syndrome

About this section
Sources:
44NIH Rare Diseases, 35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MedlinePlus:35 Polycystic ovary syndrome (pcos) happens when a woman's ovaries or adrenal glands produce more male hormones than normal. one result is that cysts (fluid-filled sacs) develop on the ovaries. women who are obese are more likely to have polycystic ovary syndrome. symptoms of pcos include: infertility pelvic pain excess hair growth on the face, chest, stomach, thumbs, or toes baldness or thinning hair acne, oily skin, or dandruff patches of thickened dark brown or black skin women with pcos are at higher risk of diabetes, metabolic syndrome, heart disease, and high blood pressure. medicines can help control the symptoms. birth control pills help women have normal periods, reduce male hormone levels, and clear acne. other medicines can reduce hair growth and control blood pressure and cholesterol. there is no cure. nih: national institute of child health and human development

MalaCards: Polycystic Ovary Syndrome, also known as polycystic ovaries, is related to insulin resistance and obesity. An important gene associated with Polycystic Ovary Syndrome is SHBG (sex hormone-binding globulin), and among its related pathways are Estrone metabolism and Nongenotropic Androgen signaling. The drug urofollitropin and the compounds cyproteroneacetate and acipimox have been mentioned in the context of this disorder. Affiliated tissues include ovary, heart and skin, and related mouse phenotypes are adipose tissue and liver/biliary system.

NIH Rare Diseases:44 Polycystic ovarian syndrome (pcos) is a health problem that can affect a woman's menstrual cycle, ability to have children, hormones, heart, blood vessels, and appearance. women with this condition typically have high levels of  hormones called androgens, missed or irregular periods, and many small cysts in their ovaries. the cause of pcos is unknown, but probably involves a combination of genetic and environmental factors. treatment for pcos may involve birth control pills and medications for diabetes and infertility. medicines called anti-androgens are also used to speed the growth of hair and clear acne. last updated: 11/10/2008

Wikipedia:66 Polycystic ovary syndrome (PCOS), also called hyperandrogenic anovulation (HA), or Stein-Leventhal... more...

Description from OMIM:48 184700

Aliases & Classifications for Polycystic Ovary Syndrome

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 44NIH Rare Diseases, 36MeSH, 59SNOMED-CT, 41NCIt, 28ICD9CM, 48OMIM, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

polycystic ovary syndrome 9 11 46 35 63
polycystic ovaries 9 46
pcos 9 44
polycystic ovarian syndrome 44
polycystic ovarian disease 9
stein-leventhal syndrome 9
stein-leventhal synd. 9
multicystic ovaries 9
polycystic ovary 9


External Ids:

Disease Ontology9 DOID:11612
MeSH36 D011085
NCIt41 C26862
ICD9CM28 256.4
OMIM48 184700
ICD1026 E28.2

Related Diseases for Polycystic Ovary Syndrome

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Polycystic Ovary Syndrome family:

Polycystic Ovary Syndrome 1

Diseases related to Polycystic Ovary Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 225)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.6IGFBP1, SHBG, ADIPOQ, FST, RETN, GHRL
2obesity31.5LEP, INS, CYP11A1, IGFBP1, RBP4, CAPN10
3hyperandrogenism31.3SULT2A1, IGFBP1, CYP17A1, CYP11A1, INS, LEP
4anovulation31.0LEP, INS, IGFBP1, GNRH1, SHBG, AMH
5hypertension30.9RETN, INS, CYP17A1, LEP
6premature ovarian failure30.9BMP15, AMH, GDF9, GNRH1
7acanthosis nigricans30.9INS, SHBG, ADIPOQ, LEP
8infertility30.9CAPN10, BMP15, RETN, FSHB, GDF9, IGFBP1
9acne30.8SHBG
10ovarian hyperstimulation syndrome30.8FSHB, GNRH1
11glucose intolerance30.8ADIPOQ, LEP, INS, IGFBP1, CAPN10, GHRL
12hyperinsulinism30.8SHBG, GNRH1, LEP, INS, IGFBP1, SULT2A1
13amenorrhea30.8SULT2A1, AMH, SHBG, GNRH1, LEP, INS
14hyperprolactinemia30.7GNRH1, SHBG
15diabetes mellitus30.7GHRL, IGFBP1, RBP4, CAPN10, RETN, ADIPOQ
16precocious puberty30.7GNRH1, SHBG, AMH, LEP
17gestational diabetes30.6RBP4, CAPN10, RETN, ADIPOQ, SHBG, LEP
18fatty liver disease30.5RETN, LEP, INS, RBP4
19cushing's syndrome30.5SULT2A1, INS
20congenital adrenal hyperplasia30.5CYP17A1, GNRH1, CYP11A1
21atherosclerosis30.4ADIPOQ, LEP, RETN, GHRL, INS, CAPN10
22obstructive sleep apnea30.4ADIPOQ, LEP
23adrenal adenoma30.4CYP17A1, SULT2A1, CYP11A1
24type 2 diabetes mellitus30.4RETN, RBP4, CAPN10, GHRL, ADIPOQ, LEP
25vascular disease30.4RETN, ADIPOQ, INS
26pituitary tumors30.4FSHB, GHRL, GNRH1, FST
27type 1 diabetes mellitus30.3LEP, RETN, INS, IGFBP1, RBP4
28coronary artery disease30.3GHRL, RETN, ADIPOQ, INS, IGFBP1
29ovarian disease30.3IGFBP1, GNRH1, SHBG
30rabson-mendenhall syndrome30.3INS
31pseudohermaphroditism30.3AMH, CYP17A1
32morbid obesity30.2INS, LEP, GHRL
33eating disorder30.2RETN, GHRL, LEP
34hyperglycemia30.2INS, RETN, LEP, IGFBP1, ADIPOQ, GHRL
35endometrial carcinoma30.2IGFBP1, FST, GNRH1, CYP17A1
36turner syndrome30.2BMP15, IGFBP1, SHBG
37proteinuria30.2RBP4, ADIPOQ, INS
38lipodystrophy30.1INS, RETN, ADIPOQ, LEP
39hypogonadism30.1GHRL, FSHB, INS, LEP, SHBG, ADIPOQ
40hypothyroidism30.1SHBG, LEP, RETN, INS, GNRH1, GHRL
41pituitary adenoma30.1GNRH1, LEP, GHRL, FSHB, FST
42congenital generalized lipodystrophy type 230.1INS, LEP, ADIPOQ
43pre-eclampsia30.0SHBG, ADIPOQ, IGFBP1, LEP, FST, RETN
44anorexia nervosa29.9SHBG, IGFBP1, LEP, ADIPOQ, GHRL, RETN
45adenoma29.9CYP11A1, CYP17A1, INS, IGFBP1, GNRH1, SHBG
46hypoglycemia29.9GHRL, IGFBP1, INS, GNRH1
47hypercholesterolemia29.8INS, RBP4, CAPN10, RETN, ADIPOQ
48acromegaly29.8IGFBP1, INS, LEP, GNRH1, SHBG, ADIPOQ
49endometriosis29.8FST, CYP17A1, CYP11A1, GNRH1, ADIPOQ, IGFBP1
50breast cancer29.6RBP4, IGFBP1, SULT2A1, AMH, SHBG, GNRH1

Graphical network of the top 20 diseases related to Polycystic Ovary Syndrome:



Diseases related to polycystic ovary syndrome

Symptoms for Polycystic Ovary Syndrome

About this section
Sources:
48OMIM
See all sources


Clinical features from OMIM:

184700

Drugs & Therapeutics for Polycystic Ovary Syndrome

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Polycystic Ovary Syndrome

Drug clinical trials:

Search ClinicalTrials for Polycystic Ovary Syndrome

Search NIH Clinical Center for Polycystic Ovary Syndrome

Search CenterWatch for Polycystic Ovary Syndrome

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Polycystic Ovary Syndrome

About this section

Anatomical Context for Polycystic Ovary Syndrome

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Polycystic Ovary Syndrome:

34
Ovary, Heart, Skin, Adrenal gland, Endothelial, Adipocyte, Testes, Pituitary, Bone, Skeletal muscle, Thyroid, Liver, Monocytes, Brain, Prostate, Breast, Whole blood, Cortex, Tongue, Pancreas, Kidney, Placenta, Eye, Adrenal cortex

Animal Models for Polycystic Ovary Syndrome or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Polycystic Ovary Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.2CAPN10, GHRL, RETN, ADIPOQ, LEP, INS
2MP:00053707.9RETN, ADIPOQ, GNRH1, LEP, INS, CAPN10
3MP:00053697.7RBP4, FST, ADIPOQ, LEP, CYP11A1, INS
4MP:00053896.3INS, RBP4, BMP15, FSHB, FST, AMH
5MP:00053795.7BMP15, FST, GHRL, CAPN10, RBP4, ADIPOQ
6MP:00053765.3RBP4, CAPN10, GHRL, RETN, GDF9, CYP17A1

Publications for Polycystic Ovary Syndrome

About this section
Sources:
53PubMed
See all sources

Articles related to Polycystic Ovary Syndrome:

(show top 50)    (show all 1919)
idTitleAuthorsYear
1
Association of serum pigment epithelium-derived factor with high-sensitivity C-reactive protein in women with polycystic ovary syndrome. (24105071)
2013
2
Ovulation induction in the management of anovulatory polycystic ovary syndrome. (23084977)
2013
3
Cardiovascular disease in polycystic ovary syndrome. (23362921)
2013
4
TNF-I+ haplotype association with polycystic ovary syndrome - a South Indian study. (23975191)
2013
5
To what extent does the use of the Rotterdam criteria affect the prevalence of polycystic ovary syndrome? A community-based study from the Southwest of Iran. (24411130)
2013
6
RETRACTION: Variations in different polycystic ovary syndrome phenotypes in a population of Chinese Han. (24258306)
2013
7
Associations of adiponectin gene polymorphisms with polycystic ovary syndrome: a meta-analysis. (22270872)
2012
8
Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome. (21717173)
2011
9
Increased plasma metastin levels in adolescent women with polycystic ovary syndrome. (20022159)
2010
10
Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. (20378617)
2010
11
Insulin resistance and overweight-obese women with polycystic ovary syndrome. (19903118)
2010
12
Fibrillins in adult human ovary and polycystic ovary syndrome: is fibrillin-3 affected in PCOS? (20855553)
2010
13
Decreased adiponectin levels in polycystic ovary syndrome, independent of body mass index. (19929617)
2010
14
Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors. (19131059)
2010
15
Obesity and polycystic ovary syndrome. (20054201)
2009
16
Effect of sibutramine on weight reduction and insulin resistance in women with polycystic ovary syndrome. (19362719)
2009
17
Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome? (19094071)
2009
18
Correlates of increased lean muscle mass in women with polycystic ovary syndrome. (19605540)
2009
19
The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes. (19625203)
2009
20
Plasminogen activator and plasma activator inhibitor-1 in young women with polycystic ovary syndrome. (18029284)
2008
21
Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic ovary syndrome. (17803698)
2008
22
Regulation of catechol O-methyltransferase expression in granulosa cells: a potential role for follicular arrest in polycystic ovary syndrome. (17612537)
2008
23
Low-density lipoprotein receptor-related protein-5 C/T polymorphism in exon 18 is associated with C peptide and proinsulin levels in control women and patients with polycystic ovary syndrome. (17953969)
2008
24
Polycystic ovary syndrome in the Indian Subcontinent. (18181079)
2008
25
Androgen receptor gene CAG(n) trinucleotide repeats polymorphism in Chinese women with polycystic ovary syndrome. (18483883)
2008
26
Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. (17582143)
2007
27
Polycystic ovary syndrome and the single nucleotide polymorphisms of methylenetetrahydrofolate reductase: a pilot observational study. (17454207)
2007
28
A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome. (16764871)
2006
29
Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism. (16603055)
2006
30
Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea. (16839844)
2006
31
The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: a pilot study. (16359551)
2005
32
FEM1A is a candidate gene for polycystic ovary syndrome. (16390781)
2005
33
Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulin-resistant women with polycystic ovary syndrome. (15598674)
2005
34
Subclinical eating disorder, polycystic ovary syndrome- is there any connection between these two conditions through leptin- a twin study. (16570705)
2005
35
What may be the markers of the male equivalent of polycystic ovary syndrome? (15209536)
2004
36
Insulin secretion in women who have polycystic ovary syndrome and carry the Gly972Arg variant of insulin receptor substrate-1 in response to a high-glycemic or low-glycemic carbohydrate load. (15474880)
2004
37
The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome. (15063963)
2004
38
Leptin and its association with polycystic ovary syndrome: a twin study. (15497495)
2004
39
Polycystic ovary syndrome: syndrome XX? (14516934)
2003
40
The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome. (11375796)
2001
41
Metabolic and endocrine consequences of acute suppression of FFAs by acipimox in polycystic ovary syndrome. (11701699)
2001
42
Study on the relationship between a polymorphism of tumor necrosis factor-alpha gene and the pathogenesis of polycystic ovary syndrome]. (11775944)
2000
43
Effect of opioid blockade on insulin and growth hormone (GH) secretion in patients with polycystic ovary syndrome: the heterogeneity of impaired GH secretion is related to both obesity and hyperinsulinism. (9935127)
1999
44
Usefulness of a 12-month treatment with finasteride in idiophathic and polycystic ovary syndrome-associated hirsutism. (10668160)
1999
45
Involvement of growth factors in the pathophysiology of polycystic ovary syndrome. (10065164)
1998
46
The plasminogen activator system in women with polycystic ovary syndrome. (9496335)
1998
47
Role of cytochrome P450c17 in polycystic ovary syndrome. (9922107)
1998
48
The effects of gonadotrophin-releasing hormone agonist on follicular development in patients with polycystic ovary syndrome in an in-vitro fertilization and embryo transfer programme. (7836506)
1994
49
Increased circulating levels of immunoreactive beta-endorphin in polycystic ovary syndrome is not caused by increased pituitary secretion. (1471704)
1992
50
Changes in circulating hormone levels after ovarian wedge resection in patients with polycystic ovary syndrome. (2124095)
1990

Variations for Polycystic Ovary Syndrome

About this section

Expression for genes affiliated with Polycystic Ovary Syndrome

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Polycystic Ovary Syndrome

Search GEO for disease gene expression data for Polycystic Ovary Syndrome.

Pathways for genes affiliated with Polycystic Ovary Syndrome

About this section
Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 5Cell Signaling Technology, 13EMD Millipore, 55R&D Systems, 54QIAGEN
See all sources

Pathways related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Estrogen biosynthesis61
Androstenedione and testosterone biosynthesis and metabolism p.161
10.0SULT2A1, CYP17A1
210.0GNRH1, SHBG
39.5FSHB, GNRH1
4
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.5LEP, INS, CYP17A1
59.4ADIPOQ, INS, CYP11A1
69.0INS, LEP, ADIPOQ, RETN
7
Show member pathways
8.9GHRL, FSHB, LEP, INS
88.7IGFBP1, INS, LEP, FSHB
9
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.6INS, LEP, ADIPOQ, RETN, RBP4
108.5BMP15, FSHB, INS, CYP11A1, CYP17A1, GDF9
11
Show member pathways
8.5IGFBP1, INS, LEP, FSHB, GHRL
12
Show member pathways
7.4INS, LEP, GNRH1, FST, FSHB, GHRL

Compounds for genes affiliated with Polycystic Ovary Syndrome

About this section
Sources:
46Novoseek, 30IUPHAR, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 25HMDB
See all sources

Compounds related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 170)
idCompoundScoreTop Affiliating Genes
1cyproteroneacetate469.3GNRH1, GHRL, INS, SHBG
2acipimox46 3010.2INS, LEP, GHRL, ADIPOQ
3nash469.1ADIPOQ, RETN, LEP, INS
4clomiphene citrate469.1INS, GNRH1, IGFBP1, FSHB, SHBG
5thiazolidinedione469.0INS, LEP, ADIPOQ, CYP17A1, RETN
6orlistat46 62 1211.0LEP, GHRL, INS, ADIPOQ
7octreotide46 62 30 1211.9ADIPOQ, INS, IGFBP1, GNRH1, GHRL
8triiodothyronine468.9IGFBP1, SHBG, SULT2A1, GHRL, RBP4, LEP
911beta-hydroxysteroid468.9CYP11A1, RETN, ADIPOQ, CYP17A1, LEP
10progestin468.8SHBG, IGFBP1, CYP11A1, GNRH1, ADIPOQ, CYP17A1
11triacylglycerol468.7INS, LEP, ADIPOQ, GHRL, RBP4
12tamoxifen46 52 30 1211.7GNRH1, CYP17A1, LEP, SHBG, SULT2A1, AMH
13uric acid46 259.6INS, LEP, ADIPOQ, RETN, RBP4
14carbohydrates468.6IGFBP1, GHRL, ADIPOQ, SHBG, LEP, INS
15nifedipine46 30 52 1211.6ADIPOQ, GNRH1, CYP11A1, CYP17A1, LEP, GHRL
1617-hydroxyprogesterone46 259.6RETN, ADIPOQ, SHBG, GNRH1, CYP11A1, CYP17A1
17epinephrine46 25 1210.6GHRL, SHBG, GNRH1, LEP, INS, IGFBP1
18estrone46 30 25 1211.5SULT2A1, SHBG, LEP, CYP17A1, IGFBP1, GNRH1
19c-peptide468.5IGFBP1, GHRL, RETN, ADIPOQ, LEP, INS
20corticosterone46 62 2510.4LEP, GHRL, IGFBP1, CYP17A1, CYP11A1
21norepinephrine46 25 1210.1INS, RETN, ADIPOQ, SHBG, GNRH1, IGFBP1
22forskolin46 52 1210.1FST, CYP11A1, SULT2A1, RETN, GHRL, CYP17A1
23fatty acid468.0IGFBP1, ADIPOQ, GHRL, RBP4, RETN, LEP
24pioglitazone30 46 52 1210.9RBP4, ADIPOQ, SHBG, LEP, RETN, GHRL
25arginine467.9LEP, GNRH1, CAPN10, GHRL, ADIPOQ, INS
26rosiglitazone30 46 52 25 1211.9CYP17A1, IGFBP1, INS, LEP, RBP4, GHRL
27thyroxine46 258.8IGFBP1, INS, LEP, GNRH1, SHBG, ADIPOQ
28dhea467.7GHRL, IGFBP1, RETN, ADIPOQ, SULT2A1, SHBG
29vitamin a46 25 129.7RBP4, IGFBP1, CYP17A1, LEP, ADIPOQ, FST
30lactate467.6ADIPOQ, GNRH1, INS, SHBG, IGFBP1, RBP4
31ribonucleic acid467.6CYP17A1, CYP11A1, RBP4, GHRL, FST, GDF9
32metformin46 52 129.6IGFBP1, GHRL, RETN, ADIPOQ, SHBG, GNRH1
33dihydrotestosterone46 30 25 1210.6ADIPOQ, SHBG, GNRH1, LEP, CYP11A1, FST
34actinomycin d467.4RETN, FSHB, FST, ADIPOQ, CYP11A1, IGFBP1
35dehydroepiandrosterone sulfate467.3IGFBP1, CYP17A1, CYP11A1, RBP4, GHRL, ADIPOQ
36adenylate467.3FST, RBP4, GHRL, FSHB, ADIPOQ, SHBG
37cholesterol46 30 25 1210.1RBP4, IGFBP1, CYP17A1, CYP11A1, INS, LEP
38lipid467.1RETN, CYP17A1, CYP11A1, INS, IGFBP1, GHRL
39glucose467.0SHBG, FST, RETN, ADIPOQ, GHRL, CAPN10
40androstenedione46 258.0RBP4, FST, ADIPOQ, SHBG, GNRH1, LEP
41gnrh467.0GNRH1, SHBG, FSHB, GHRL, LEP, INS
42creatinine466.9SHBG, INS, GHRL, FST, ADIPOQ, GNRH1
43acth466.8LEP, INS, CYP11A1, GNRH1, SHBG, SULT2A1
44cysteine466.8IGFBP1, RBP4, CAPN10, RETN, FSHB, FST
45steroid466.6RBP4, GNRH1, CYP11A1, FSHB, SULT2A1, SHBG
46dexamethasone46 52 30 129.2GNRH1, SHBG, SULT2A1, ADIPOQ, FST, RETN
47progesterone46 30 62 25 1210.1RBP4, AMH, SULT2A1, FST, FSHB, RETN
48estradiol46 25 128.0IGFBP1, CYP17A1, CYP11A1, LEP, GNRH1, SHBG
49estrogen465.3IGFBP1, CYP17A1, CYP11A1, RBP4, GHRL, RETN
50testosterone46 62 25 128.3RBP4, GHRL, RETN, FSHB, FST, ADIPOQ

GO Terms for genes affiliated with Polycystic Ovary Syndrome

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.0GHRL, INS
2extracellular spaceGO:0056156.8RBP4, GDF9, IGFBP1, INS, LEP, GNRH1
3extracellular regionGO:0055765.7GNRH1, LEP, INS, IGFBP1, SHBG, AMH

Biological processes related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1response to fungicideGO:06099210.2CYP17A1, CYP11A1
2negative regulation of feeding behaviorGO:200025210.2RETN, INS
3dibenzo-p-dioxin metabolic processGO:01889410.2CYP17A1, CYP11A1
4biphenyl metabolic processGO:01887910.2CYP17A1, CYP11A1
5phthalate metabolic processGO:01896310.2CYP17A1, CYP11A1
6phenol-containing compound metabolic processGO:01895810.2CYP17A1, CYP11A1
7response to insecticideGO:01708510.2CYP17A1, CYP11A1
8cellular response to antibioticGO:07123610.1CYP11A1, CYP17A1
9positive regulation of insulin receptor signaling pathwayGO:04662810.0INS, LEP
10steroid metabolic processGO:00820210.0SULT2A1, CYP11A1, CYP17A1
11sex differentiationGO:00754810.0AMH, CYP17A1
12Leydig cell differentiationGO:03332710.0CYP11A1, CYP17A1
13adult feeding behaviorGO:00834310.0LEP, GHRL
14positive regulation of insulin secretionGO:03202410.0RBP4, CAPN10, GHRL
15negative regulation of gluconeogenesisGO:04572110.0INS, ADIPOQ
16sterol metabolic processGO:0161259.9CYP11A1, CYP17A1
17response to vitamin EGO:0331979.9LEP, CYP11A1
18positive regulation of glucose importGO:0463269.9INS, ADIPOQ, CAPN10
19positive regulation of cellular protein metabolic processGO:0322709.9INS, ADIPOQ
20progesterone biosynthetic processGO:0067019.8FSHB, CYP11A1
21female gamete generationGO:0072929.7BMP15, FSHB, GDF9
22response to insulinGO:0328689.7LEP, RETN, RBP4
23glucose homeostasisGO:0425939.6INS, ADIPOQ, RBP4
24response to ethanolGO:0454719.5GNRH1, ADIPOQ, RBP4
25xenobiotic metabolic processGO:0068059.4SULT2A1, CYP11A1, CYP17A1
26female pregnancyGO:0075659.4FSHB, GNRH1, LEP
27glucose metabolic processGO:0060069.4GHRL, ADIPOQ, LEP, INS
28cellular protein metabolic processGO:0442678.9GHRL, FSHB, INS, IGFBP1
29positive regulation of cell proliferationGO:0082848.8GDF9, INS, LEP, FSHB

Molecular functions related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5BMP15, ADIPOQ, GDF9
2growth factor activityGO:0080839.0GDF9, LEP, AMH, BMP15
3hormone activityGO:0051797.7RETN, FSHB, ADIPOQ, AMH, GNRH1, LEP

Products for genes affiliated with Polycystic Ovary Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polycystic Ovary Syndrome

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet