PCOS
MCID: PLY011
MIFTS: 68

Polycystic Ovary Syndrome (PCOS) malady

Endocrine diseases category

Summaries for Polycystic Ovary Syndrome

About this section
Sources:
42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Polycystic ovary syndrome (pcos) happens when a woman's ovaries or adrenal glands produce more male hormones than normal. one result is that cysts (fluid-filled sacs) develop on the ovaries. women who are obese are more likely to have polycystic ovary syndrome. symptoms of pcos include: infertility pelvic pain excess hair growth on the face, chest, stomach, thumbs, or toes baldness or thinning hair acne, oily skin, or dandruff patches of thickened dark brown or black skin women with pcos are at higher risk of diabetes, metabolic syndrome, heart disease, and high blood pressure. medicines can help control the symptoms. birth control pills help women have normal periods, reduce male hormone levels, and clear acne. other medicines can reduce hair growth and control blood pressure and cholesterol. there is no cure. nih: national institute of child health and human development

MalaCards: Polycystic Ovary Syndrome, also known as polycystic ovaries, is related to obesity and hyperandrogenism. An important gene associated with Polycystic Ovary Syndrome is SULT2A1 (sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1), and among its related pathways are Ovarian steroidogenesis and Adipogenesis. The drug urofollitropin and the compounds testosterone and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include ovary, heart and skin, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

NIH Rare Diseases:42 Polycystic ovarian syndrome (pcos) is a health problem that can affect a woman's menstrual cycle, ability to have children, hormones, heart, blood vessels, and appearance. women with this condition typically have high levels of  hormones called androgens, missed or irregular periods, and many small cysts in their ovaries. the cause of pcos is unknown, but probably involves a combination of genetic and environmental factors. treatment for pcos may involve birth control pills and medications for diabetes and infertility. medicines called anti-androgens are also used to speed the growth of hair and clear acne. last updated: 11/10/2008

Wikipedia:63 Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among females. PCOS has a... more...

Description from OMIM:46 184700

Aliases & Classifications for Polycystic Ovary Syndrome

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 39NCIt, 46OMIM, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

polycystic ovary syndrome 8 10 44 33 60
polycystic ovaries 8 44
pcos 8 42
polycystic ovarian syndrome 42
polycystic ovarian disease 8
stein-leventhal syndrome 8
stein-leventhal synd. 8
multicystic ovaries 8
polycystic ovary 8


External Ids:

Disease Ontology8 DOID:11612
NCIt39 C26862
OMIM46 184700
ICD9CM27 256.4
MeSH34 D011085
ICD1025 E28.2

Related Diseases for Polycystic Ovary Syndrome

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Polycystic Ovary Syndrome family:

Polycystic Ovary Syndrome 1

Diseases related to Polycystic Ovary Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1obesity31.9CAPN10, LSL, RBP4, GHRL, SHBG, IGFBP1
2hyperandrogenism31.7SHBG, IGFBP1, CYP17A1, CYP11A1, RETN, INS
3infertility31.3LSL, GNRH1, BMP15, SHBG, IGFBP1, CYP11A1
4anovulation31.1IGFBP1, INS, LEP, SULT2A1, SHBG, GHRL
5glucose intolerance31.0CAPN10, LSL, RBP4, GHRL, SHBG, IGFBP1
6diabetes mellitus31.0CAPN10, LSL, RBP4, GHRL, SHBG, IGFBP1
7hyperinsulinism30.9LSL, GNRH1, GHRL, SHBG, IGFBP1, RETN
8hypertension30.9CYP17A1, RETN, INS, LEP
9acanthosis nigricans30.9SHBG, INS, LEP, ADIPOQ
10gestational diabetes30.9LSL, RBP4, SHBG, IGFBP1, RETN, NAMPT
11ovarian hyperstimulation syndrome30.8GNRH1
12premature ovarian failure30.8GNRH1, BMP15, SHBG, CYP11A1, GDF9
13amenorrhea30.8AMH, GNRH1, BMP15, SHBG, INS, LEP
14type 2 diabetes mellitus30.7CAPN10, LSL, RBP4, GHRL, SHBG, IGFBP1
15atherosclerosis30.7CAPN10, LSL, RBP4, GHRL, SHBG, RETN
16hyperprolactinemia30.6SHBG, GNRH1
17hepatitis30.6IGFBP1
18acne30.6SHBG
19fatty liver disease30.5RBP4, CYP17A1, RETN, INS, LEP, ADIPOQ
20down syndrome30.5FST
21hyperglycemia30.4LSL, GHRL, IGFBP1, RETN, NAMPT, INS
22cushing's syndrome30.4INS, SULT2A1
23coronary artery disease30.4GHRL, IGFBP1, RETN, NAMPT, INS, ADIPOQ
24congenital adrenal hyperplasia30.4CYP11A1, CYP17A1, GNRH1, LSL
25vascular disease30.4ADIPOQ, INS, NAMPT, RETN
26ovarian disease30.4GNRH1, SHBG, IGFBP1
27pancreatitis30.4INS
28graves' disease30.3SHBG
29hypogonadism30.3GNRH1, GHRL, SHBG, INS, LEP, ADIPOQ
30pituitary adenoma30.3GNRH1, GHRL, LEP, FST
31adrenal adenoma30.2CYP17A1, CYP11A1, SULT2A1
32acromegaly30.1ADIPOQ, LSL, GNRH1, GHRL, SHBG, IGFBP1
33adenoma30.1GNRH1, GHRL, SHBG, IGFBP1, CYP17A1, CYP11A1
34pre-eclampsia30.1LSL, SHBG, IGFBP1, RETN, LEP, FST
35morbid obesity30.1LSL, GHRL, RETN, INS, LEP, ADIPOQ
36hypothyroidism30.1LSL, GHRL, SHBG, RETN, LEP, ADIPOQ
37lipodystrophy30.1ADIPOQ, LEP, INS, RETN, LSL
38metabolic syndrome x30.1LSL, IGFBP1, INS, LEP, ADIPOQ
39eating disorder30.1LSL, GHRL, RETN, LEP
40proteinuria30.1LSL, RBP4, INS, ADIPOQ
41adenocarcinoma30.1IGFBP1, GHRL
42prolactinoma30.1GNRH1
43anorexia nervosa30.1LSL, GHRL, SHBG, IGFBP1, RETN, LEP
44ovarian cancer30.1GNRH1, RBP4, CYP17A1, FST
45klinefelter's syndrome30.1SHBG, GNRH1
46endometrial carcinoma30.1GNRH1, IGFBP1, CYP17A1, FST
47congenital generalized lipodystrophy type 230.0LSL, INS, LEP, ADIPOQ
48turner syndrome30.0IGFBP1, SHBG, BMP15
49diabetic retinopathy30.0IGFBP1, INS
50hypogonadotropism30.0GNRH1

Graphical network of the top 20 diseases related to Polycystic Ovary Syndrome:



Diseases related to polycystic ovary syndrome

Clinical Features for Polycystic Ovary Syndrome

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

184700

Drugs & Therapeutics for Polycystic Ovary Syndrome

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Polycystic Ovary Syndrome

Drug clinical trials:

Search ClinicalTrials for Polycystic Ovary Syndrome

Search NIH Clinical Center for Polycystic Ovary Syndrome

Search CenterWatch for Polycystic Ovary Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Polycystic Ovary Syndrome

About this section

Anatomical Context for Polycystic Ovary Syndrome

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Polycystic Ovary Syndrome:

32
Ovary, Heart, Skin, Adrenal gland, Endothelial, Adipocyte, Testes, Pituitary, Thyroid, Skeletal muscle, Bone, Liver, Monocytes, Brain, Prostate, Breast, Tongue, Adrenal cortex, Kidney, Whole blood, Placenta, Cortex, Pancreas, Eye

Animal Models for Polycystic Ovary Syndrome or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Polycystic Ovary Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.9CYP17A1, GHRL, RBP4, GNRH1, CAPN10, AMH
2MP:000537911.3FST, AMH, CAPN10, BMP15, RBP4, CYP11A1
3MP:000538911.0AMH, GNRH1, BMP15, RBP4, CYP11A1, GDF9
4MP:000537010.9CAPN10, GNRH1, IGFBP1, RETN, INS, LEP
5MP:000537510.7RETN, CAPN10

Publications for Polycystic Ovary Syndrome

About this section
Sources:
50PubMed
See all sources

Articles related to Polycystic Ovary Syndrome:

(show top 50)    (show all 1963)
idTitleAuthorsYear
1
Metabolic, Behavioral, and Reproductive Effects of Vertical Sleeve Gastrectomy in an Obese Rat Model of Polycystic Ovary Syndrome. (24408363)
2014
2
Integrative techniques using acupuncture, Chinese herbal medicine, diet, and supplements for polycystic ovary syndrome: a case report. (24299606)
2013
3
Association between menstrual cycle irregularities and endocrine and metabolic characteristics of the polycystic ovary syndrome. (23109645)
2013
4
Gastric bypass surgery in women with or without polycystic ovary syndrome-A comparative observational cohort analysis. (24140258)
2013
5
The relationship between copper, homocysteine and early vascular disease in lean women with polycystic ovary syndrome. (23480818)
2013
6
Statin Therapy Worsens Insulin Sensitivity in Women With Polycystic Ovary Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study. (24152688)
2013
7
Quantitative analysis of follistatin (FST) promoter methylation in peripheral blood of patients with polycystic ovary syndrome. (23265961)
2013
8
Can high serum anti-MA1llerian hormone levels predict the phenotypes of polycystic ovary syndrome (PCOS) and metabolic disturbances in PCOS patients? (24179872)
2013
9
Impact of cod protein on insulin sensitivity in women with polycystic ovary syndrome. (24070765)
2013
10
Effects of metformin use in pregnant patients with polycystic ovary syndrome. (23162354)
2012
11
Insulin resistant phenotype of polycystic ovary syndrome does not seem to be caused by variation in FTO. (22847851)
2012
12
Polycystic ovary syndrome is associated with higher left ventricular mass index: the CARDIA women's study. (23012389)
2012
13
Serum albumin levels in women with ovarian hyperstimulation syndrome with or without polycystic ovaries. (22971456)
2012
14
Does the level of serum antimA1llerian hormone predict ovulatory function in women with polycystic ovary syndrome with aging? (22771030)
2012
15
A meta-analysis on the association between PPAR-I^ Pro12Ala polymorphism and polycystic ovary syndrome. (22527903)
2012
16
Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome. (21717173)
2011
17
Serum lipocalin-2 as an insulin resistance marker in patients with polycystic ovary syndrome. (20511727)
2011
18
Serum vaspin and C-reactive protein levels in women with polycystic ovaries and polycystic ovary syndrome. (20626239)
2011
19
Increased plasma metastin levels in adolescent women with polycystic ovary syndrome. (20022159)
2010
20
Association of polymorphisms of interleukin-18 gene promoter region with polycystic ovary syndrome in chinese population. (20964873)
2010
21
Unilateral ovarian enlargement in adolescents with polycystic ovary syndrome: a variant of bilateral disease. (20432811)
2010
22
Serum soluble glycoprotein 130 concentration is inversely related to insulin sensitivity in women with polycystic ovary syndrome. (20103703)
2010
23
The prevalence of Gly972Arg and C825T polymorphisms in Slovak women with polycystic ovary syndrome and their relation to the metabolic syndrome. (20170352)
2010
24
Insulin resistance as link between polycystic ovary syndrome and cardiovascular autonomic dysfunction. (18639353)
2009
25
The relationship between follistatin and chronic low-grade inflammation in women with polycystic ovary syndrome. (19591997)
2009
26
Determinants of interleukin-6 and C-reactive protein vary in polycystic ovary syndrome, as do effects of short- and long-term metformin therapy. (19188739)
2009
27
Effects of an antiandrogenic oral contraceptive pill compared with metformin on blood coagulation tests and endothelial function in women with the polycystic ovary syndrome: influence of obesity and smoking. (19139031)
2009
28
Effects of growth hormone reduction in a patient with polycystic ovary syndrome complicated with acromegaly. (18840925)
2009
29
Body fat and insulin resistance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome. (19713424)
2009
30
Plasma monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha are increased in patients with polycystic ovary syndrome (PCOS) and associated with adiposity, but unaffected by pioglitazone treatment. (19170716)
2009
31
Cardiometabolic abnormalities in the polycystic ovary syndrome: pharmacotherapeutic insights. (18602948)
2008
32
Metabolic syndrome in women with polycystic ovary syndrome]. (18646307)
2007
33
The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome. (17445549)
2007
34
Insulin sensitivity after metformin suspension in normal-weight women with polycystic ovary syndrome. (17519312)
2007
35
Insulin resistance may be involved in relationship between cardiac autonomic dysfunction and polycystic ovary syndrome. (17970965)
2007
36
The genetics of the polycystic ovary syndrome. (17237837)
2007
37
Effect of laparoscopic ovarian diathermy on circulating inhibin B in women with anovulatory polycystic ovary syndrome. (17525068)
2007
38
Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation. (15531516)
2004
39
Serum leptin levels in normal-weight and overweight women with polycystic ovary syndrome. (14664414)
2003
40
Polycystic ovaries, precocious puberty and acquired hypothyroidism: The Van Wyk and Grumbach syndrome. (14523827)
2003
41
Regulation of gonadotropin secretion: implications for polycystic ovary syndrome. (12536355)
2002
42
Glucose intolerance in obese adolescents with polycystic ovary syndrome: roles of insulin resistance and beta-cell dysfunction and risk of cardiovascular disease. (11231980)
2001
43
Prolactin and polycystic ovary syndrome]. (11412704)
2001
44
Pulsatile luteinising hormone releasing hormone for ovulation induction in subfertility associated with polycystic ovary syndrome. (10796718)
2000
45
Neuropeptide Y, leptin, galanin and insulin in women with polycystic ovary syndrome. (10599552)
1999
46
The plasminogen activator system in women with polycystic ovary syndrome. (9496335)
1998
47
Low levels of follicle-stimulating hormone receptor-activation inhibitors in serum and follicular fluid from normal controls and anovulatory patients with or without polycystic ovary syndrome. (9141511)
1997
48
Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. (7635975)
1995
49
Expression of inhibin alpha, beta A and beta B messenger ribonucleic acids in the normal human ovary and in polycystic ovarian syndrome. (7964311)
1994
50
Hyperandrogenism in polycystic ovary syndrome. (8208262)
1994

Genetic Variations for Polycystic Ovary Syndrome

About this section

Expression for genes affiliated with Polycystic Ovary Syndrome

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Polycystic Ovary Syndrome

Search GEO for disease gene expression data for Polycystic Ovary Syndrome.

Pathways for genes affiliated with Polycystic Ovary Syndrome

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 53Reactome
See all sources

Compounds for genes affiliated with Polycystic Ovary Syndrome

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2415.4GHRL, ADIPOQ, SULT2A1, SHBG, IGFBP1, CYP17A1
2cholesterol44 28 11 2415.3SULT2A1, LEP, INS, NAMPT, RETN, CYP11A1
3lipid4412.3GHRL, SHBG, RETN, IGFBP1, CYP17A1, NAMPT
4progesterone44 59 28 11 2416.2AMH, FST, SULT2A1, LEP, RETN, BMP15
5creatinine4412.1LSL, GNRH1, RBP4, GHRL, NAMPT, SHBG
6metformin44 49 1114.1CYP17A1, SHBG, GHRL, CYP11A1, RETN, NAMPT
7dexamethasone44 49 28 1115.1FST, INS, NAMPT, RETN, CYP11A1, CYP17A1
8dhea4412.0CYP11A1, ADIPOQ, SULT2A1, LEP, INS, RETN
9rosiglitazone44 49 28 11 2416.0CYP17A1, RETN, NAMPT, INS, LEP, ADIPOQ
10androstenedione44 2413.0LSL, GNRH1, RBP4, SHBG, IGFBP1, CYP17A1
11steroid4411.9SHBG, IGFBP1, RBP4, GNRH1, CYP17A1, LEP
12thyroxine44 2412.9LSL, GNRH1, ADIPOQ, LEP, INS, RETN
13pioglitazone44 49 28 1114.9SHBG, IGFBP1, CYP17A1, RETN, NAMPT, INS
14acth4411.8SULT2A1, FST, LEP, CYP11A1, IGFBP1, GHRL
15arginine4411.8CYP17A1, ADIPOQ, LEP, INS, SHBG, GHRL
16ribonucleic acid4411.8FST, CYP17A1, NAMPT, GDF9, GNRH1, RBP4
17fatty acid4411.7GHRL, IGFBP1, RETN, INS, ADIPOQ, NAMPT
18lactate4411.7FST, IGFBP1, GNRH1, GHRL, LSL, SHBG
19c-peptide4411.7SHBG, GHRL, IGFBP1, RETN, LEP, ADIPOQ
20estrone44 28 11 2414.7ADIPOQ, IGFBP1, CYP17A1, LSL, GNRH1, SHBG
21dihydrotestosterone44 28 11 2414.7IGFBP1, SHBG, GNRH1, CYP17A1, CYP11A1, LEP
22estradiol44 11 2413.6AMH, GNRH1, SHBG, CYP17A1, CYP11A1, FST
23dehydroepiandrosterone sulfate4411.6GNRH1, RBP4, SHBG, IGFBP1, CYP11A1, SULT2A1
24gnrh4411.6GNRH1, GHRL, CYP11A1, CYP17A1, IGFBP1, SHBG
25tamoxifen44 49 28 1114.6LSL, GNRH1, SHBG, IGFBP1, SULT2A1, AMH
2617-hydroxyprogesterone44 2412.6GNRH1, ADIPOQ, RETN, CYP11A1, CYP17A1, IGFBP1
27triiodothyronine4411.6GHRL, SULT2A1, LEP, IGFBP1, SHBG, RBP4
28carbohydrates4411.5ADIPOQ, LEP, INS, IGFBP1, GHRL, LSL
29vitamin a44 11 2413.4CYP17A1, FST, ADIPOQ, RETN, LEP, IGFBP1
30octreotide44 59 28 1114.4LSL, GNRH1, IGFBP1, INS, ADIPOQ, GHRL
31triacylglycerol4411.4LSL, LEP, RBP4, GHRL, INS, ADIPOQ
32epinephrine44 11 2413.4INS, LEP, SHBG, LSL, GNRH1, GHRL
33progestin4411.4CYP11A1, GNRH1, SHBG, IGFBP1, ADIPOQ, CYP17A1
34glucose4411.3NAMPT, LSL, GHRL, FST, RBP4
35acipimox44 2812.3GHRL, INS, LSL, LEP, ADIPOQ
36nash4411.3INS, LEP, RETN, LSL, ADIPOQ
37corticosterone44 59 2413.3IGFBP1, GHRL, CYP11A1, LEP, LSL, CYP17A1
38orlistat44 59 1113.3LEP, ADIPOQ, LSL, INS, GHRL
39p0024411.3RBP4, LSL, IGFBP1, RETN, LEP, ADIPOQ
40thiazolidinedione4411.3LEP, RETN, INS, CYP17A1, ADIPOQ
41hydrocortisone44 2 59 1114.2ADIPOQ, LSL, INS, GHRL, IGFBP1, SHBG
4211beta-hydroxysteroid4411.2RETN, ADIPOQ, LEP, CYP11A1, CYP17A1
43alanine4411.2LSL, RBP4, ADIPOQ, SHBG, RETN, INS
44nifedipine44 49 28 1114.1CYP17A1, GHRL, GNRH1, ADIPOQ, LEP, CYP11A1
45valproate4411.1SHBG, IGFBP1, LSL, CYP17A1, CYP11A1
46norepinephrine44 11 2413.1RETN, GNRH1
47sibutramine44 1112.0INS, LEP, LSL, ADIPOQ
48beta-hydroxybutyrate4410.9INS, LEP, IGFBP1, LSL
49olanzapine49 44 28 11 2414.9LEP, ADIPOQ, INS, GHRL, LSL
50fibrinogen4410.9RETN, ADIPOQ, LEP, IGFBP1, INS, NAMPT

GO Terms for genes affiliated with Polycystic Ovary Syndrome

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.5ADIPOQ, AMH, GNRH1, BMP15, RBP4, GHRL
2extracellular regionGO:00557611.3GHRL, RBP4, GNRH1, AMH, SHBG, IGFBP1
3secretory granule lumenGO:03477410.7INS, GHRL

Biological processes related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1glucose metabolic processGO:00600611.2ADIPOQ, LEP, INS, GHRL
2positive regulation of glucose importGO:04632611.1ADIPOQ, INS, CAPN10
3positive regulation of insulin secretionGO:03202411.1CAPN10, RBP4, GHRL
4cell-cell signalingGO:00726711.1AMH, GNRH1, NAMPT, INS
5response to insulin stimulusGO:03286811.1LEP, RETN, RBP4
6steroid metabolic processGO:00820211.0SULT2A1, CYP11A1, CYP17A1
7response to fungicideGO:06099211.0CYP17A1, CYP11A1
8dibenzo-p-dioxin metabolic processGO:01889411.0CYP17A1, CYP11A1
9biphenyl metabolic processGO:01887911.0CYP17A1, CYP11A1
10response to insecticideGO:01708511.0CYP17A1, CYP11A1
11phthalate metabolic processGO:01896311.0CYP17A1, CYP11A1
12phenol-containing compound metabolic processGO:01895811.0CYP17A1, CYP11A1
13response to ethanolGO:04547111.0ADIPOQ, RBP4, GNRH1
14positive regulation of insulin receptor signaling pathwayGO:04662810.9INS, LEP
15glucose homeostasisGO:04259310.9RBP4, INS, ADIPOQ
16negative regulation of gluconeogenesisGO:04572110.9ADIPOQ, INS
17cellular response to antibioticGO:07123610.9CYP11A1, CYP17A1
18adult feeding behaviorGO:00834310.8LEP, GHRL
19response to vitamin EGO:03319710.7LEP, CYP11A1
20Leydig cell differentiationGO:03332710.7CYP17A1, CYP11A1
21sterol metabolic processGO:01612510.7CYP11A1, CYP17A1
22positive regulation of cellular protein metabolic processGO:03227010.6INS, ADIPOQ
23sex differentiationGO:00754810.4CYP17A1, AMH

Molecular functions related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517911.0ADIPOQ, LEP, INS, RETN, GNRH1, AMH
2cytokine activityGO:00512510.9ADIPOQ, NAMPT, GDF9, BMP15
3growth factor activityGO:00808310.6AMH, BMP15, GDF9, LEP

Products for genes affiliated with Polycystic Ovary Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polycystic Ovary Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet