PCOS
MCID: PLY011
MIFTS: 68

Polycystic Ovary Syndrome (PCOS) malady

Rare diseases, Endocrine diseases categories
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Summaries for Polycystic Ovary Syndrome

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MedlinePlus:33 Polycystic ovary syndrome (pcos) happens when a woman's ovaries or adrenal glands produce more male hormones than normal. one result is that cysts (fluid-filled sacs) develop on the ovaries. women who are obese are more likely to have polycystic ovary syndrome. symptoms of pcos include: infertility pelvic pain excess hair growth on the face, chest, stomach, thumbs, or toes baldness or thinning hair acne, oily skin, or dandruff patches of thickened dark brown or black skin women with pcos are at higher risk of diabetes, metabolic syndrome, heart disease, and high blood pressure. medicines can help control the symptoms. birth control pills help women have normal periods, reduce male hormone levels, and clear acne. other medicines can reduce hair growth and control blood pressure and cholesterol. there is no cure. nih: national institute of child health and human development

MalaCards based summary: Polycystic Ovary Syndrome, also known as polycystic ovarian syndrome, is related to acne and premature ovarian failure. An important gene associated with Polycystic Ovary Syndrome is SHBG (sex hormone-binding globulin), and among its related pathways are Estrone metabolism and Nongenotropic Androgen signaling. The drug urofollitropin and the compounds cyproteroneacetate and acipimox have been mentioned in the context of this disorder. Affiliated tissues include ovary, heart and skin, and related mouse phenotypes are adipose tissue and liver/biliary system.

NIH Rare Diseases:42 Polycystic ovarian syndrome (pcos) is a health problem that can affect a woman's menstrual cycle, ability to have children, hormones, heart, blood vessels, and appearance. women with this condition typically have high levels of  hormones called androgens, missed or irregular periods, and many small cysts in their ovaries. the cause of pcos is unknown, but probably involves a combination of genetic and environmental factors. treatment for pcos may involve birth control pills and medications for diabetes and infertility. medicines called anti-androgens are also used to speed the growth of hair and clear acne. last updated: 11/10/2008

Wikipedia:65 Polycystic ovary syndrome (PCOS), also called hyperandrogenic anovulation (HA), or Stein-Leventhal... more...

Description from OMIM:46 184700

Aliases & Classifications for Polycystic Ovary Syndrome

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Polycystic Ovary Syndrome, Aliases & Descriptions:

Name: Polycystic Ovary Syndrome 30 8 10 44 33 62
Polycystic Ovarian Syndrome 42 62
Polycystic Ovarian Disease 8 62
Polycystic Ovaries 8 44
Pcos 8 42
 
Stein-Leventhal Syndrome 8
Stein-Leventhal Synd. 8
Multicystic Ovaries 8
Polycystic Ovary 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:11612
ICD9CM27 256.4
MeSH34 D011085
OMIM46 184700
NCIt39 C26862
ICD1025 E28.2

Related Diseases for Polycystic Ovary Syndrome

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Diseases in the Polycystic Ovary Syndrome family:

Polycystic Ovary Syndrome 1

Diseases related to Polycystic Ovary Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1acne31.5SHBG
2premature ovarian failure31.2GDF9, GNRH1, AMH, BMP15
3ovarian hyperstimulation syndrome31.1GNRH1, FSHB
4hyperprolactinemia31.1SHBG, GNRH1
5hypertension31.0CYP17A1, INS, LEP, RETN
6rabson-mendenhall syndrome30.9INS
7cushing's syndrome30.8SULT2A1, INS
8precocious puberty30.8LEP, GNRH1, SHBG, AMH
9acanthosis nigricans30.8ADIPOQ, SHBG, LEP, INS
10congenital adrenal hyperplasia30.7GNRH1, CYP11A1, CYP17A1
11adrenal adenoma30.7CYP17A1, CYP11A1, SULT2A1
12pseudohermaphroditism30.7AMH, CYP17A1
13ovarian disease30.5IGFBP1, GNRH1, SHBG
14amenorrhea30.5INS, LEP, GNRH1, SHBG, AMH, SULT2A1
15anovulation30.5SHBG, AMH, SULT2A1, GHRL, GNRH1, IGFBP1
16fatty liver disease30.5RBP4, RETN, LEP, INS
17turner syndrome30.5IGFBP1, SHBG, BMP15
18obstructive sleep apnea30.5LEP, ADIPOQ
19pituitary tumors30.5GNRH1, FST, FSHB, GHRL
20morbid obesity30.4INS, LEP, GHRL
21eating disorder30.4LEP, RETN, GHRL
22insulin resistance30.3IGFBP1, CYP17A1, INS, LEP, SHBG, ADIPOQ
23endometrial carcinoma30.3IGFBP1, CYP17A1, GNRH1, FST
24vascular disease30.3INS, ADIPOQ, RETN
25hyperinsulinism30.2IGFBP1, INS, LEP, GNRH1, SHBG, SULT2A1
26obesity30.1LEP, SHBG, ADIPOQ, FST, RETN, GHRL
27proteinuria30.0INS, ADIPOQ, RBP4
28type 1 diabetes mellitus30.0IGFBP1, INS, LEP, RETN, RBP4
29congenital generalized lipodystrophy type 230.0INS, LEP, ADIPOQ
30hypoglycemia30.0IGFBP1, INS, GNRH1, GHRL
31lipodystrophy29.9RETN, ADIPOQ, LEP, INS
32hypothyroidism29.9INS, LEP, GNRH1, SHBG, RETN, GHRL
33hyperandrogenism29.9CYP11A1, CAPN10, INS, LEP, GNRH1, SHBG
34pituitary adenoma29.8LEP, GNRH1, FST, FSHB, GHRL
35gestational diabetes29.7ADIPOQ, RETN, CAPN10, RBP4, SHBG, LEP
36hyperglycemia29.7IGFBP1, INS, LEP, ADIPOQ, RETN, GHRL
37glucose intolerance29.7RBP4, IGFBP1, INS, LEP, SHBG, ADIPOQ
38diabetes mellitus29.7IGFBP1, INS, LEP, SHBG, ADIPOQ, RETN
39hypercholesterolemia29.6INS, ADIPOQ, RETN, CAPN10, RBP4
40atherosclerosis29.5INS, LEP, SHBG, ADIPOQ, FST, RETN
41pre-eclampsia29.5IGFBP1, LEP, SHBG, ADIPOQ, FST, RETN
42hypogonadism29.4INS, LEP, GHRL, FSHB, ADIPOQ, SHBG
43infertility29.4CYP11A1, INS, LEP, GNRH1, SHBG, AMH
44anorexia nervosa29.3IGFBP1, LEP, SHBG, ADIPOQ, RETN, GHRL
45adenoma29.3IGFBP1, CYP17A1, CYP11A1, INS, GNRH1, SHBG
46type 2 diabetes mellitus29.3IGFBP1, INS, LEP, SHBG, ADIPOQ, RETN
47endometriosis29.3IGFBP1, CYP17A1, CYP11A1, GNRH1, ADIPOQ, FST
48acromegaly29.0LEP, GNRH1, SHBG, ADIPOQ, RETN, GHRL
49breast cancer28.6IGFBP1, CYP17A1, CYP11A1, INS, LEP, GNRH1
50endotheliitis10.8

Graphical network of the top 20 diseases related to Polycystic Ovary Syndrome:



Diseases related to polycystic ovary syndrome

Symptoms for Polycystic Ovary Syndrome

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Clinical features from OMIM:

184700

Drugs & Therapeutics for Polycystic Ovary Syndrome

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Drug clinical trials:

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Search NIH Clinical Center for Polycystic Ovary Syndrome

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Polycystic Ovary Syndrome

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Anatomical Context for Polycystic Ovary Syndrome

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MalaCards organs/tissues related to Polycystic Ovary Syndrome:

32
Ovary, Heart, Skin, Adrenal gland, Endothelial, Adipocyte, Testes, Pituitary, Bone, Skeletal muscle, Thyroid, Liver, Brain, Monocytes, Prostate, Breast, Eye, Whole blood, Cortex, Kidney, Pancreas, Placenta, Tongue, Adrenal cortex, Neutrophil

Animal Models for Polycystic Ovary Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Polycystic Ovary Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.2CAPN10, GHRL, RETN, ADIPOQ, LEP, INS
2MP:00053707.9RETN, ADIPOQ, GNRH1, LEP, INS, CAPN10
3MP:00053697.7RBP4, FST, ADIPOQ, LEP, CYP11A1, INS
4MP:00053896.3INS, RBP4, BMP15, FSHB, FST, AMH
5MP:00053795.7BMP15, FST, GHRL, CAPN10, RBP4, ADIPOQ
6MP:00053765.3RBP4, CAPN10, GHRL, RETN, GDF9, CYP17A1

Publications for Polycystic Ovary Syndrome

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Articles related to Polycystic Ovary Syndrome:

(show top 50)    (show all 1963)
idTitleAuthorsYear
1
A possible role of polycystic ovary syndrome for pregnancy complications in women with psoriasis. (25381981)
2014
2
How medical treatment affects mean platelet volume as a cardiovascular risk marker in polycystic ovary syndrome? (25402193)
2014
3
Association of serum pigment epithelium-derived factor with high-sensitivity C-reactive protein in women with polycystic ovary syndrome. (24105071)
2013
4
Ovulation induction in the management of anovulatory polycystic ovary syndrome. (23084977)
2013
5
Cardiovascular disease in polycystic ovary syndrome. (23362921)
2013
6
TNF-I+ haplotype association with polycystic ovary syndrome - a South Indian study. (23975191)
2013
7
Obesity, adipokines and metabolic syndrome in polycystic ovary syndrome. (24002404)
2013
8
To what extent does the use of the Rotterdam criteria affect the prevalence of polycystic ovary syndrome? A community-based study from the Southwest of Iran. (24411130)
2013
9
Associations of adiponectin gene polymorphisms with polycystic ovary syndrome: a meta-analysis. (22270872)
2012
10
Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome. (21717173)
2011
11
Increased plasma metastin levels in adolescent women with polycystic ovary syndrome. (20022159)
2010
12
Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. (20378617)
2010
13
Insulin resistance and overweight-obese women with polycystic ovary syndrome. (19903118)
2010
14
Fibrillins in adult human ovary and polycystic ovary syndrome: is fibrillin-3 affected in PCOS? (20855553)
2010
15
Decreased adiponectin levels in polycystic ovary syndrome, independent of body mass index. (19929617)
2010
16
Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors. (19131059)
2010
17
Obesity and polycystic ovary syndrome. (20054201)
2009
18
Effect of sibutramine on weight reduction and insulin resistance in women with polycystic ovary syndrome. (19362719)
2009
19
Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome? (19094071)
2009
20
Correlates of increased lean muscle mass in women with polycystic ovary syndrome. (19605540)
2009
21
The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes. (19625203)
2009
22
Plasminogen activator and plasma activator inhibitor-1 in young women with polycystic ovary syndrome. (18029284)
2008
23
Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic ovary syndrome. (17803698)
2008
24
Regulation of catechol O-methyltransferase expression in granulosa cells: a potential role for follicular arrest in polycystic ovary syndrome. (17612537)
2008
25
Low-density lipoprotein receptor-related protein-5 C/T polymorphism in exon 18 is associated with C peptide and proinsulin levels in control women and patients with polycystic ovary syndrome. (17953969)
2008
26
Polycystic ovary syndrome in the Indian Subcontinent. (18181079)
2008
27
Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. (17582143)
2007
28
Polycystic ovary syndrome and the single nucleotide polymorphisms of methylenetetrahydrofolate reductase: a pilot observational study. (17454207)
2007
29
A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome. (16764871)
2006
30
Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism. (16603055)
2006
31
The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: a pilot study. (16359551)
2005
32
FEM1A is a candidate gene for polycystic ovary syndrome. (16390781)
2005
33
Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulin-resistant women with polycystic ovary syndrome. (15598674)
2005
34
Subclinical eating disorder, polycystic ovary syndrome- is there any connection between these two conditions through leptin- a twin study. (16570705)
2005
35
What may be the markers of the male equivalent of polycystic ovary syndrome? (15209536)
2004
36
Insulin secretion in women who have polycystic ovary syndrome and carry the Gly972Arg variant of insulin receptor substrate-1 in response to a high-glycemic or low-glycemic carbohydrate load. (15474880)
2004
37
The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome. (15063963)
2004
38
Leptin and its association with polycystic ovary syndrome: a twin study. (15497495)
2004
39
Polycystic ovary syndrome: syndrome XX? (14516934)
2003
40
The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome. (11375796)
2001
41
Metabolic and endocrine consequences of acute suppression of FFAs by acipimox in polycystic ovary syndrome. (11701699)
2001
42
Study on the relationship between a polymorphism of tumor necrosis factor-alpha gene and the pathogenesis of polycystic ovary syndrome]. (11775944)
2000
43
Effect of opioid blockade on insulin and growth hormone (GH) secretion in patients with polycystic ovary syndrome: the heterogeneity of impaired GH secretion is related to both obesity and hyperinsulinism. (9935127)
1999
44
Usefulness of a 12-month treatment with finasteride in idiophathic and polycystic ovary syndrome-associated hirsutism. (10668160)
1999
45
Involvement of growth factors in the pathophysiology of polycystic ovary syndrome. (10065164)
1998
46
The plasminogen activator system in women with polycystic ovary syndrome. (9496335)
1998
47
Role of cytochrome P450c17 in polycystic ovary syndrome. (9922107)
1998
48
The effects of gonadotrophin-releasing hormone agonist on follicular development in patients with polycystic ovary syndrome in an in-vitro fertilization and embryo transfer programme. (7836506)
1994
49
Increased circulating levels of immunoreactive beta-endorphin in polycystic ovary syndrome is not caused by increased pituitary secretion. (1471704)
1992
50
Changes in circulating hormone levels after ovarian wedge resection in patients with polycystic ovary syndrome. (2124095)
1990

Variations for Polycystic Ovary Syndrome

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Expression for genes affiliated with Polycystic Ovary Syndrome

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Expression patterns in normal tissues for genes affiliated with Polycystic Ovary Syndrome

Search GEO for disease gene expression data for Polycystic Ovary Syndrome.

Pathways for genes affiliated with Polycystic Ovary Syndrome

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Pathways related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Estrogen biosynthesis60
Androstenedione and testosterone biosynthesis and metabolism p.160
10.0SULT2A1, CYP17A1
210.0GNRH1, SHBG
39.5FSHB, GNRH1
4
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.5CYP17A1, INS, LEP
59.4ADIPOQ, INS, CYP11A1
69.0ADIPOQ, INS, LEP, RETN
7
Show member pathways
8.9INS, LEP, FSHB, GHRL
88.7IGFBP1, INS, FSHB, LEP
9
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.6ADIPOQ, RETN, LEP, INS, RBP4
108.5CYP11A1, FSHB, INS, CYP17A1, BMP15, GDF9
11
Show member pathways
8.5INS, IGFBP1, LEP, FSHB, GHRL
12
Show member pathways
7.4INS, LEP, RBP4, GHRL, FSHB, FST

Compounds for genes affiliated with Polycystic Ovary Syndrome

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Compounds related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 170)
idCompoundScoreTop Affiliating Genes
1cyproteroneacetate449.3GNRH1, GHRL, INS, SHBG
2acipimox44 2810.2INS, LEP, GHRL, ADIPOQ
3nash449.1ADIPOQ, RETN, LEP, INS
4clomiphene citrate449.1INS, GNRH1, IGFBP1, FSHB, SHBG
5thiazolidinedione449.0INS, LEP, ADIPOQ, CYP17A1, RETN
6orlistat44 61 1111.0LEP, GHRL, INS, ADIPOQ
7octreotide44 61 28 1111.9ADIPOQ, INS, IGFBP1, GNRH1, GHRL
8triiodothyronine448.9IGFBP1, SHBG, SULT2A1, GHRL, RBP4, LEP
911beta-hydroxysteroid448.9CYP11A1, RETN, ADIPOQ, CYP17A1, LEP
10progestin448.8SHBG, IGFBP1, CYP11A1, GNRH1, ADIPOQ, CYP17A1
11triacylglycerol448.7INS, LEP, ADIPOQ, GHRL, RBP4
12tamoxifen44 50 28 1111.7GNRH1, CYP17A1, LEP, SHBG, SULT2A1, AMH
13uric acid44 249.6INS, LEP, ADIPOQ, RETN, RBP4
14carbohydrates448.6IGFBP1, GHRL, ADIPOQ, SHBG, LEP, INS
15nifedipine44 28 50 1111.6ADIPOQ, GNRH1, CYP11A1, CYP17A1, LEP, GHRL
1617-hydroxyprogesterone44 249.6RETN, ADIPOQ, SHBG, GNRH1, CYP11A1, CYP17A1
17epinephrine44 24 1110.6GHRL, SHBG, GNRH1, LEP, INS, IGFBP1
18estrone44 28 24 1111.5SULT2A1, SHBG, LEP, CYP17A1, IGFBP1, GNRH1
19c-peptide448.5IGFBP1, GHRL, RETN, ADIPOQ, LEP, INS
20corticosterone44 61 2410.4LEP, GHRL, IGFBP1, CYP17A1, CYP11A1
21norepinephrine44 24 1110.1INS, RETN, ADIPOQ, SHBG, GNRH1, IGFBP1
22forskolin44 50 1110.1FST, CYP11A1, SULT2A1, RETN, GHRL, CYP17A1
23fatty acid448.0IGFBP1, ADIPOQ, GHRL, RBP4, RETN, LEP
24pioglitazone28 44 50 1110.9RBP4, ADIPOQ, SHBG, LEP, RETN, GHRL
25arginine447.9LEP, GNRH1, CAPN10, GHRL, ADIPOQ, INS
26rosiglitazone28 44 50 24 1111.9CYP17A1, IGFBP1, INS, LEP, RBP4, GHRL
27thyroxine44 248.8IGFBP1, INS, LEP, GNRH1, SHBG, ADIPOQ
28dhea447.7GHRL, IGFBP1, RETN, ADIPOQ, SULT2A1, SHBG
29vitamin a44 24 119.7RBP4, IGFBP1, CYP17A1, LEP, ADIPOQ, FST
30lactate447.6ADIPOQ, GNRH1, INS, SHBG, IGFBP1, RBP4
31ribonucleic acid447.6CYP17A1, CYP11A1, RBP4, GHRL, FST, GDF9
32metformin44 50 119.6IGFBP1, GHRL, RETN, ADIPOQ, SHBG, GNRH1
33dihydrotestosterone44 28 24 1110.6ADIPOQ, SHBG, GNRH1, LEP, CYP11A1, FST
34actinomycin d447.4RETN, FSHB, FST, ADIPOQ, CYP11A1, IGFBP1
35dehydroepiandrosterone sulfate447.3IGFBP1, CYP17A1, CYP11A1, RBP4, GHRL, ADIPOQ
36adenylate447.3FST, RBP4, GHRL, FSHB, ADIPOQ, SHBG
37cholesterol44 28 24 1110.1RBP4, IGFBP1, CYP17A1, CYP11A1, INS, LEP
38lipid447.1RETN, CYP17A1, CYP11A1, INS, IGFBP1, GHRL
39glucose447.0SHBG, FST, RETN, ADIPOQ, GHRL, CAPN10
40androstenedione44 248.0RBP4, FST, ADIPOQ, SHBG, GNRH1, LEP
41gnrh447.0GNRH1, SHBG, FSHB, GHRL, LEP, INS
42creatinine446.9SHBG, INS, GHRL, FST, ADIPOQ, GNRH1
43acth446.8LEP, INS, CYP11A1, GNRH1, SHBG, SULT2A1
44cysteine446.8IGFBP1, RBP4, CAPN10, RETN, FSHB, FST
45steroid446.6RBP4, GNRH1, CYP11A1, FSHB, SULT2A1, SHBG
46dexamethasone44 50 28 119.2GNRH1, SHBG, SULT2A1, ADIPOQ, FST, RETN
47progesterone44 28 61 24 1110.1RBP4, AMH, SULT2A1, FST, FSHB, RETN
48estradiol44 24 118.0IGFBP1, CYP17A1, CYP11A1, LEP, GNRH1, SHBG
49estrogen445.3IGFBP1, CYP17A1, CYP11A1, RBP4, GHRL, RETN
50testosterone44 61 24 118.3RBP4, GHRL, RETN, FSHB, FST, ADIPOQ

GO Terms for genes affiliated with Polycystic Ovary Syndrome

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Cellular components related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.0GHRL, INS
2extracellular spaceGO:0056156.8GHRL, BMP15, RETN, ADIPOQ, AMH, GNRH1
3extracellular regionGO:0055765.7RBP4, IGFBP1, GHRL, FSHB, FST, ADIPOQ

Biological processes related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of feeding behaviorGO:200025210.2RETN, INS
2biphenyl metabolic processGO:01887910.2CYP17A1, CYP11A1
3dibenzo-p-dioxin metabolic processGO:01889410.2CYP11A1, CYP17A1
4response to fungicideGO:06099210.2CYP17A1, CYP11A1
5phthalate metabolic processGO:01896310.2CYP17A1, CYP11A1
6phenol-containing compound metabolic processGO:01895810.2CYP17A1, CYP11A1
7response to insecticideGO:01708510.2CYP17A1, CYP11A1
8cellular response to antibioticGO:07123610.1CYP17A1, CYP11A1
9steroid metabolic processGO:00820210.0CYP17A1, CYP11A1, SULT2A1
10positive regulation of insulin receptor signaling pathwayGO:04662810.0INS, LEP
11sex differentiationGO:00754810.0CYP17A1, AMH
12adult feeding behaviorGO:00834310.0LEP, GHRL
13Leydig cell differentiationGO:03332710.0CYP17A1, CYP11A1
14positive regulation of insulin secretionGO:03202410.0CAPN10, RBP4, GHRL
15negative regulation of gluconeogenesisGO:04572110.0ADIPOQ, INS
16sterol metabolic processGO:0161259.9CYP11A1, CYP17A1
17positive regulation of glucose importGO:0463269.9ADIPOQ, CAPN10, INS
18positive regulation of cellular protein metabolic processGO:0322709.9ADIPOQ, INS
19response to vitamin EGO:0331979.9LEP, CYP11A1
20progesterone biosynthetic processGO:0067019.8CYP11A1, FSHB
21female gamete generationGO:0072929.7BMP15, GDF9, FSHB
22response to insulinGO:0328689.7RBP4, RETN, LEP
23glucose homeostasisGO:0425939.6RBP4, ADIPOQ, INS
24response to ethanolGO:0454719.5GNRH1, ADIPOQ, RBP4
25xenobiotic metabolic processGO:0068059.4CYP11A1, SULT2A1, CYP17A1
26female pregnancyGO:0075659.4LEP, GNRH1, FSHB
27glucose metabolic processGO:0060069.4ADIPOQ, LEP, INS, GHRL
28cellular protein metabolic processGO:0442678.9GHRL, IGFBP1, INS, FSHB
29positive regulation of cell proliferationGO:0082848.8INS, GDF9, FSHB, LEP

Molecular functions related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5GDF9, ADIPOQ, BMP15
2growth factor activityGO:0080839.0AMH, BMP15, LEP, GDF9
3hormone activityGO:0051797.7GNRH1, LEP, AMH, ADIPOQ, FSHB, RETN

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