MCID: PLY011
MIFTS: 67

Polycystic Ovary Syndrome malady

Rare diseases, Endocrine diseases categories

Summaries for Polycystic Ovary Syndrome

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MedlinePlus:34 Polycystic ovary syndrome (pcos) happens when a woman's ovaries or adrenal glands produce more male hormones than normal. one result is that cysts (fluid-filled sacs) develop on the ovaries. women who are obese are more likely to have polycystic ovary syndrome. symptoms of pcos include: infertility pelvic pain excess hair growth on the face, chest, stomach, thumbs, or toes baldness or thinning hair acne, oily skin, or dandruff patches of thickened dark brown or black skin women with pcos are at higher risk of diabetes, metabolic syndrome, heart disease, and high blood pressure. medicines can help control the symptoms. birth control pills help women have normal periods, reduce male hormone levels, and clear acne. other medicines can reduce hair growth and control blood pressure and cholesterol. there is no cure. nih: national institute of child health and human development

MalaCards based summary: Polycystic Ovary Syndrome, also known as polycystic ovarian syndrome, is related to obesity and hyperandrogenism. An important gene associated with Polycystic Ovary Syndrome is SHBG (sex hormone-binding globulin), and among its related pathways are Estrone metabolism and Nongenotropic Androgen signaling. The drug urofollitropin and the compounds cyproteroneacetate and acipimox have been mentioned in the context of this disorder. Affiliated tissues include ovary, heart and skin, and related mouse phenotypes are adipose tissue and liver/biliary system.

NIH Rare Diseases:43 Polycystic ovarian syndrome (pcos) is a health problem that can affect a woman's menstrual cycle, ability to have children, hormones, heart, blood vessels, and appearance. women with this condition typically have high levels of  hormones called androgens, missed or irregular periods, and many small cysts in their ovaries. the cause of pcos is unknown, but probably involves a combination of genetic and environmental factors. treatment for pcos may involve birth control pills and medications for diabetes and infertility. medicines called anti-androgens are also used to speed the growth of hair and clear acne. last updated: 11/10/2008

Wikipedia:65 Polycystic ovary syndrome (PCOS), also called hyperandrogenic anovulation (HA), or Stein?Leventhal... more...

Aliases & Classifications for Polycystic Ovary Syndrome

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Polycystic Ovary Syndrome, Aliases & Descriptions:

Name: Polycystic Ovary Syndrome 32 10 12 45 34 62
Polycystic Ovarian Syndrome 43 62
Polycystic Ovarian Disease 10 62
Polycystic Ovaries 10 45
Pcos 10 43
 
Stein-Leventhal Syndrome 10
Stein-Leventhal Synd. 10
Multicystic Ovaries 10
Polycystic Ovary 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology10 DOID:11612
ICD9CM29 256.4
MeSH35 D011085
NCIt40 C26862
ICD1027 E28.2

Related Diseases for Polycystic Ovary Syndrome

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Diseases in the Polycystic Ovary Syndrome family:

Polycystic Ovary Syndrome 1

Diseases related to Polycystic Ovary Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1obesity31.7LEP, SHBG, ADIPOQ, FST, RETN, GHRL
2hyperandrogenism31.5CYP11A1, CAPN10, INS, LEP, GNRH1, SHBG
3infertility31.1CYP11A1, INS, LEP, GNRH1, SHBG, AMH
4anovulation31.1SHBG, AMH, SULT2A1, GHRL, GNRH1, IGFBP1
5acanthosis nigricans30.9ADIPOQ, SHBG, LEP, INS
6glucose intolerance30.9RBP4, IGFBP1, INS, LEP, SHBG, ADIPOQ
7premature ovarian failure30.9GDF9, GNRH1, AMH, BMP15
8hyperinsulinism30.9IGFBP1, INS, LEP, GNRH1, SHBG, SULT2A1
9ovarian hyperstimulation syndrome30.8GNRH1, FSHB
10amenorrhea30.8INS, LEP, GNRH1, SHBG, AMH, SULT2A1
11acne30.8SHBG
12liver disease30.7LEP, INS
13hyperprolactinemia30.7SHBG, GNRH1
14precocious puberty30.7LEP, GNRH1, SHBG, AMH
15fatty liver disease30.7RBP4, RETN, LEP, INS
16atherosclerosis30.6INS, LEP, SHBG, ADIPOQ, FST, RETN
17cushing's syndrome30.5SULT2A1, INS
18congenital adrenal hyperplasia30.5GNRH1, CYP11A1, CYP17A1
19hyperglycemia30.5IGFBP1, INS, LEP, ADIPOQ, RETN, GHRL
20endometrial cancer30.5IGFBP1, CYP17A1, GNRH1, FST
21obstructive sleep apnea30.4LEP, ADIPOQ
22rabson-mendenhall syndrome30.4INS
23vascular disease30.4INS, ADIPOQ, RETN
24pituitary tumors30.4GNRH1, FST, FSHB, GHRL
25coronary artery disease30.4IGFBP1, INS, ADIPOQ, RETN, GHRL
26adrenal adenoma30.4CYP17A1, CYP11A1, SULT2A1
27turner syndrome30.4IGFBP1, SHBG, BMP15
28adenoma30.3IGFBP1, CYP17A1, CYP11A1, INS, GNRH1, SHBG
29ovarian disease30.3IGFBP1, GNRH1, SHBG
30hypogonadism30.2INS, LEP, GHRL, FSHB, ADIPOQ, SHBG
31morbid obesity30.2INS, LEP, GHRL
32eating disorder30.2LEP, RETN, GHRL
33pseudohermaphroditism30.2AMH, CYP17A1
34proteinuria30.2INS, ADIPOQ, RBP4
35lipodystrophy30.2RETN, ADIPOQ, LEP, INS
36hypothyroidism30.2INS, LEP, GNRH1, SHBG, RETN, GHRL
37pituitary adenoma30.1LEP, GNRH1, FST, FSHB, GHRL
38acromegaly30.1LEP, GNRH1, SHBG, ADIPOQ, RETN, GHRL
39anorexia nervosa30.1IGFBP1, LEP, SHBG, ADIPOQ, RETN, GHRL
40hypoglycemia29.9IGFBP1, INS, GNRH1, GHRL
41endometriosis29.9IGFBP1, CYP17A1, CYP11A1, GNRH1, ADIPOQ, FST
42breast cancer29.8IGFBP1, CYP17A1, CYP11A1, INS, LEP, GNRH1
43endotheliitis10.8
44insulin-like growth factor i10.7
45thyroiditis10.7
46blindness10.6
47polycystic ovary syndrome 110.5
48hepatitis10.5
49fowler's syndrome10.5
50autoimmune thyroiditis10.4

Graphical network of the top 20 diseases related to Polycystic Ovary Syndrome:



Diseases related to polycystic ovary syndrome

Symptoms for Polycystic Ovary Syndrome

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Drugs & Therapeutics for Polycystic Ovary Syndrome

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Drug clinical trials:

Search ClinicalTrials for Polycystic Ovary Syndrome

Search NIH Clinical Center for Polycystic Ovary Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Polycystic Ovary Syndrome

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Anatomical Context for Polycystic Ovary Syndrome

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MalaCards organs/tissues related to Polycystic Ovary Syndrome:

33
Ovary, Heart, Skin, Adrenal gland, Endothelial, Adipocyte, Testes, Thyroid, Pituitary, Liver, Bone, Skeletal muscle, Brain, Monocytes, Prostate, Breast, Eye, Whole blood, Cortex, Kidney, Pancreas, Placenta, Tongue, Adrenal cortex, Neutrophil

Animal Models for Polycystic Ovary Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Polycystic Ovary Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.2INS, LEP, ADIPOQ, RETN, GHRL, CAPN10
2MP:00053707.9IGFBP1, INS, LEP, GNRH1, ADIPOQ, RETN
3MP:00053697.7RBP4, FST, ADIPOQ, LEP, INS, CYP11A1
4MP:00053896.3GDF9, CYP17A1, CYP11A1, INS, LEP, GNRH1
5MP:00053795.7RBP4, GDF9, CYP11A1, INS, LEP, GNRH1
6MP:00053765.3GNRH1, LEP, INS, CYP11A1, CYP17A1, GDF9

Publications for Polycystic Ovary Syndrome

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Articles related to Polycystic Ovary Syndrome:

(show top 50)    (show all 2002)
idTitleAuthorsYear
1
Personality profile in patients with polycystic ovary syndrome. (25884894)
2015
2
A possible role of polycystic ovary syndrome for pregnancy complications in women with psoriasis. (25381981)
2014
3
How medical treatment affects mean platelet volume as a cardiovascular risk marker in polycystic ovary syndrome? (25402193)
2014
4
Association of serum pigment epithelium-derived factor with high-sensitivity C-reactive protein in women with polycystic ovary syndrome. (24105071)
2013
5
Ovulation induction in the management of anovulatory polycystic ovary syndrome. (23084977)
2013
6
Cardiovascular disease in polycystic ovary syndrome. (23362921)
2013
7
TNF-I+ haplotype association with polycystic ovary syndrome - a South Indian study. (23975191)
2013
8
Obesity, adipokines and metabolic syndrome in polycystic ovary syndrome. (24002404)
2013
9
To what extent does the use of the Rotterdam criteria affect the prevalence of polycystic ovary syndrome? A community-based study from the Southwest of Iran. (24411130)
2013
10
Associations of adiponectin gene polymorphisms with polycystic ovary syndrome: a meta-analysis. (22270872)
2012
11
Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome. (21717173)
2011
12
Increased plasma metastin levels in adolescent women with polycystic ovary syndrome. (20022159)
2010
13
Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. (20378617)
2010
14
Insulin resistance and overweight-obese women with polycystic ovary syndrome. (19903118)
2010
15
Fibrillins in adult human ovary and polycystic ovary syndrome: is fibrillin-3 affected in PCOS? (20855553)
2010
16
Decreased adiponectin levels in polycystic ovary syndrome, independent of body mass index. (19929617)
2010
17
Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors. (19131059)
2010
18
Obesity and polycystic ovary syndrome. (20054201)
2009
19
Effect of sibutramine on weight reduction and insulin resistance in women with polycystic ovary syndrome. (19362719)
2009
20
Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome? (19094071)
2009
21
Correlates of increased lean muscle mass in women with polycystic ovary syndrome. (19605540)
2009
22
The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes. (19625203)
2009
23
Plasminogen activator and plasma activator inhibitor-1 in young women with polycystic ovary syndrome. (18029284)
2008
24
Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic ovary syndrome. (17803698)
2008
25
Regulation of catechol O-methyltransferase expression in granulosa cells: a potential role for follicular arrest in polycystic ovary syndrome. (17612537)
2008
26
Low-density lipoprotein receptor-related protein-5 C/T polymorphism in exon 18 is associated with C peptide and proinsulin levels in control women and patients with polycystic ovary syndrome. (17953969)
2008
27
Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. (17582143)
2007
28
Polycystic ovary syndrome and the single nucleotide polymorphisms of methylenetetrahydrofolate reductase: a pilot observational study. (17454207)
2007
29
A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome. (16764871)
2006
30
Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism. (16603055)
2006
31
The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: a pilot study. (16359551)
2005
32
FEM1A is a candidate gene for polycystic ovary syndrome. (16390781)
2005
33
Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulin-resistant women with polycystic ovary syndrome. (15598674)
2005
34
Subclinical eating disorder, polycystic ovary syndrome- is there any connection between these two conditions through leptin- a twin study. (16570705)
2005
35
What may be the markers of the male equivalent of polycystic ovary syndrome? (15209536)
2004
36
Insulin secretion in women who have polycystic ovary syndrome and carry the Gly972Arg variant of insulin receptor substrate-1 in response to a high-glycemic or low-glycemic carbohydrate load. (15474880)
2004
37
The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome. (15063963)
2004
38
Leptin and its association with polycystic ovary syndrome: a twin study. (15497495)
2004
39
Polycystic ovary syndrome: syndrome XX? (14516934)
2003
40
The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome. (11375796)
2001
41
Metabolic and endocrine consequences of acute suppression of FFAs by acipimox in polycystic ovary syndrome. (11701699)
2001
42
Study on the relationship between a polymorphism of tumor necrosis factor-alpha gene and the pathogenesis of polycystic ovary syndrome]. (11775944)
2000
43
Effect of opioid blockade on insulin and growth hormone (GH) secretion in patients with polycystic ovary syndrome: the heterogeneity of impaired GH secretion is related to both obesity and hyperinsulinism. (9935127)
1999
44
Usefulness of a 12-month treatment with finasteride in idiophathic and polycystic ovary syndrome-associated hirsutism. (10668160)
1999
45
Involvement of growth factors in the pathophysiology of polycystic ovary syndrome. (10065164)
1998
46
The plasminogen activator system in women with polycystic ovary syndrome. (9496335)
1998
47
Role of cytochrome P450c17 in polycystic ovary syndrome. (9922107)
1998
48
The effects of gonadotrophin-releasing hormone agonist on follicular development in patients with polycystic ovary syndrome in an in-vitro fertilization and embryo transfer programme. (7836506)
1994
49
Increased circulating levels of immunoreactive beta-endorphin in polycystic ovary syndrome is not caused by increased pituitary secretion. (1471704)
1992
50
Changes in circulating hormone levels after ovarian wedge resection in patients with polycystic ovary syndrome. (2124095)
1990

Variations for Polycystic Ovary Syndrome

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Expression for genes affiliated with Polycystic Ovary Syndrome

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Search GEO for disease gene expression data for Polycystic Ovary Syndrome.

Pathways for genes affiliated with Polycystic Ovary Syndrome

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Pathways related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Estrogen biosynthesis60
Androstenedione and testosterone biosynthesis and metabolism p.160
10.0SULT2A1, CYP17A1
210.0GNRH1, SHBG
39.5FSHB, GNRH1
4
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.5LEP, INS, CYP17A1
59.4ADIPOQ, INS, CYP11A1
69.0INS, LEP, ADIPOQ, RETN
7
Show member pathways
8.9GHRL, FSHB, LEP, INS
88.7IGFBP1, INS, LEP, FSHB
9
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.6INS, LEP, ADIPOQ, RETN, RBP4
108.5BMP15, FSHB, INS, CYP11A1, CYP17A1, GDF9
11
Show member pathways
8.5IGFBP1, INS, LEP, FSHB, GHRL
12
Show member pathways
7.4INS, LEP, GNRH1, FST, FSHB, GHRL

Compounds for genes affiliated with Polycystic Ovary Syndrome

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Compounds related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 170)
idCompoundScoreTop Affiliating Genes
1cyproteroneacetate459.3GNRH1, GHRL, INS, SHBG
2acipimox45 3010.2INS, LEP, GHRL, ADIPOQ
3nash459.1ADIPOQ, RETN, LEP, INS
4clomiphene citrate459.1INS, GNRH1, IGFBP1, FSHB, SHBG
5thiazolidinedione459.0INS, LEP, ADIPOQ, CYP17A1, RETN
6orlistat45 61 1311.0LEP, GHRL, INS, ADIPOQ
7octreotide45 61 30 1311.9ADIPOQ, INS, IGFBP1, GNRH1, GHRL
8triiodothyronine458.9IGFBP1, SHBG, SULT2A1, GHRL, RBP4, LEP
911beta-hydroxysteroid458.9CYP11A1, RETN, ADIPOQ, CYP17A1, LEP
10progestin458.8SHBG, IGFBP1, CYP11A1, GNRH1, ADIPOQ, CYP17A1
11triacylglycerol458.7INS, LEP, ADIPOQ, GHRL, RBP4
12tamoxifen45 51 30 1311.7GNRH1, CYP17A1, LEP, SHBG, SULT2A1, AMH
13uric acid45 269.6INS, LEP, ADIPOQ, RETN, RBP4
14carbohydrates458.6IGFBP1, GHRL, ADIPOQ, SHBG, LEP, INS
15nifedipine45 30 51 1311.6ADIPOQ, GNRH1, CYP11A1, CYP17A1, LEP, GHRL
1617-hydroxyprogesterone45 269.6RETN, ADIPOQ, SHBG, GNRH1, CYP11A1, CYP17A1
17epinephrine45 26 1310.6GHRL, SHBG, GNRH1, LEP, INS, IGFBP1
18estrone45 30 26 1311.5SULT2A1, SHBG, LEP, CYP17A1, IGFBP1, GNRH1
19c-peptide458.5IGFBP1, GHRL, RETN, ADIPOQ, LEP, INS
20corticosterone45 61 2610.4LEP, GHRL, IGFBP1, CYP17A1, CYP11A1
21norepinephrine45 26 1310.1INS, RETN, ADIPOQ, SHBG, GNRH1, IGFBP1
22forskolin45 51 1310.1FST, CYP11A1, SULT2A1, RETN, GHRL, CYP17A1
23fatty acid458.0IGFBP1, ADIPOQ, GHRL, RBP4, RETN, LEP
24pioglitazone30 45 51 1310.9RBP4, ADIPOQ, SHBG, LEP, RETN, GHRL
25arginine457.9LEP, GNRH1, CAPN10, GHRL, ADIPOQ, INS
26rosiglitazone30 45 51 26 1311.9CYP17A1, IGFBP1, INS, LEP, RBP4, GHRL
27thyroxine45 268.8IGFBP1, INS, LEP, GNRH1, SHBG, ADIPOQ
28dhea457.7GHRL, IGFBP1, RETN, ADIPOQ, SULT2A1, SHBG
29vitamin a45 26 139.7RBP4, IGFBP1, CYP17A1, LEP, ADIPOQ, FST
30lactate457.6ADIPOQ, GNRH1, INS, SHBG, IGFBP1, RBP4
31ribonucleic acid457.6CYP17A1, CYP11A1, RBP4, GHRL, FST, GDF9
32metformin45 51 139.6IGFBP1, GHRL, RETN, ADIPOQ, SHBG, GNRH1
33dihydrotestosterone45 30 26 1310.6ADIPOQ, SHBG, GNRH1, LEP, CYP11A1, FST
34actinomycin d457.4RETN, FSHB, FST, ADIPOQ, CYP11A1, IGFBP1
35dehydroepiandrosterone sulfate457.3IGFBP1, CYP17A1, CYP11A1, RBP4, GHRL, ADIPOQ
36adenylate457.3FST, RBP4, GHRL, FSHB, ADIPOQ, SHBG
37cholesterol45 30 26 1310.1RBP4, IGFBP1, CYP17A1, CYP11A1, INS, LEP
38lipid457.1RETN, CYP17A1, CYP11A1, INS, IGFBP1, GHRL
39glucose457.0SHBG, FST, RETN, ADIPOQ, GHRL, CAPN10
40androstenedione45 268.0RBP4, FST, ADIPOQ, SHBG, GNRH1, LEP
41gnrh457.0GNRH1, SHBG, FSHB, GHRL, LEP, INS
42creatinine456.9SHBG, INS, GHRL, FST, ADIPOQ, GNRH1
43acth456.8LEP, INS, CYP11A1, GNRH1, SHBG, SULT2A1
44cysteine456.8IGFBP1, RBP4, CAPN10, RETN, FSHB, FST
45steroid456.6RBP4, GNRH1, CYP11A1, FSHB, SULT2A1, SHBG
46dexamethasone45 51 30 139.2GNRH1, SHBG, SULT2A1, ADIPOQ, FST, RETN
47progesterone45 30 61 26 1310.1RBP4, AMH, SULT2A1, FST, FSHB, RETN
48estradiol45 26 138.0IGFBP1, CYP17A1, CYP11A1, LEP, GNRH1, SHBG
49estrogen455.3IGFBP1, CYP17A1, CYP11A1, RBP4, GHRL, RETN
50testosterone45 61 26 138.3RBP4, GHRL, RETN, FSHB, FST, ADIPOQ

GO Terms for genes affiliated with Polycystic Ovary Syndrome

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Cellular components related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:003477410.0GHRL, INS
2extracellular spaceGO:00056156.8RBP4, GDF9, IGFBP1, INS, LEP, GNRH1
3extracellular regionGO:00055765.7GNRH1, LEP, INS, IGFBP1, SHBG, AMH

Biological processes related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1response to fungicideGO:006099210.2CYP17A1, CYP11A1
2negative regulation of feeding behaviorGO:0200025210.2RETN, INS
3dibenzo-p-dioxin metabolic processGO:001889410.2CYP17A1, CYP11A1
4biphenyl metabolic processGO:001887910.2CYP17A1, CYP11A1
5phthalate metabolic processGO:001896310.2CYP17A1, CYP11A1
6phenol-containing compound metabolic processGO:001895810.2CYP17A1, CYP11A1
7response to insecticideGO:001708510.2CYP17A1, CYP11A1
8cellular response to antibioticGO:007123610.1CYP11A1, CYP17A1
9positive regulation of insulin receptor signaling pathwayGO:004662810.0INS, LEP
10steroid metabolic processGO:000820210.0SULT2A1, CYP11A1, CYP17A1
11sex differentiationGO:000754810.0AMH, CYP17A1
12Leydig cell differentiationGO:003332710.0CYP11A1, CYP17A1
13adult feeding behaviorGO:000834310.0LEP, GHRL
14positive regulation of insulin secretionGO:003202410.0RBP4, CAPN10, GHRL
15negative regulation of gluconeogenesisGO:004572110.0INS, ADIPOQ
16sterol metabolic processGO:00161259.9CYP11A1, CYP17A1
17response to vitamin EGO:00331979.9LEP, CYP11A1
18positive regulation of glucose importGO:00463269.9INS, ADIPOQ, CAPN10
19positive regulation of cellular protein metabolic processGO:00322709.9INS, ADIPOQ
20progesterone biosynthetic processGO:00067019.8FSHB, CYP11A1
21female gamete generationGO:00072929.7BMP15, FSHB, GDF9
22response to insulinGO:00328689.7LEP, RETN, RBP4
23glucose homeostasisGO:00425939.6INS, ADIPOQ, RBP4
24response to ethanolGO:00454719.5GNRH1, ADIPOQ, RBP4
25xenobiotic metabolic processGO:00068059.4SULT2A1, CYP11A1, CYP17A1
26female pregnancyGO:00075659.4FSHB, GNRH1, LEP
27glucose metabolic processGO:00060069.4GHRL, ADIPOQ, LEP, INS
28cellular protein metabolic processGO:00442678.9GHRL, FSHB, INS, IGFBP1
29positive regulation of cell proliferationGO:00082848.8GDF9, INS, LEP, FSHB

Molecular functions related to Polycystic Ovary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.5BMP15, ADIPOQ, GDF9
2growth factor activityGO:00080839.0GDF9, LEP, AMH, BMP15
3hormone activityGO:00051797.7RETN, FSHB, ADIPOQ, AMH, GNRH1, LEP

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