MCID: PLY011
MIFTS: 59

Polycystic Ovary Syndrome malady

Rare diseases, Endocrine diseases categories

Summaries for Polycystic Ovary Syndrome

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MedlinePlus:32 Polycystic ovary syndrome (pcos) happens when a woman's ovaries or adrenal glands produce more male hormones than normal. one result is that cysts (fluid-filled sacs) develop on the ovaries. women who are obese are more likely to have polycystic ovary syndrome. symptoms of pcos include: infertility pelvic pain excess hair growth on the face, chest, stomach, thumbs, or toes baldness or thinning hair acne, oily skin, or dandruff patches of thickened dark brown or black skin women with pcos are at higher risk of diabetes, metabolic syndrome, heart disease, and high blood pressure. medicines can help control the symptoms. birth control pills help women have normal periods, reduce male hormone levels, and clear acne. other medicines can reduce hair growth and control blood pressure and cholesterol. there is no cure. nih: national institute of child health and human development

MalaCards based summary: Polycystic Ovary Syndrome, also known as polycystic ovaries, is related to acne and premature ovarian failure. An important gene associated with Polycystic Ovary Syndrome is SHBG (sex hormone-binding globulin), and among its related pathways are Estrone metabolism and Nongenotropic Androgen signaling. The drug urofollitropin and the compounds cyproteroneacetate and acipimox have been mentioned in the context of this disorder. Affiliated tissues include ovary, heart and skin, and related mouse phenotypes are adipose tissue and liver/biliary system.

NIH Rare Diseases:41 Polycystic ovarian syndrome (pcos) is a health problem that can affect a woman's menstrual cycle, ability to have children, hormones, heart, blood vessels, and appearance. women with this condition typically have high levels of  hormones called androgens, missed or irregular periods, and many small cysts in their ovaries. the cause of pcos is unknown, but probably involves a combination of genetic and environmental factors. treatment for pcos may involve birth control pills and medications for diabetes and infertility. medicines called anti-androgens are also used to speed the growth of hair and clear acne. last updated: 11/10/2008

Wikipedia:63 Polycystic ovary syndrome (PCOS), also called hyperandrogenic anovulation (HA), or Stein?Leventhal... more...

Aliases & Classifications for Polycystic Ovary Syndrome

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Polycystic Ovary Syndrome, Aliases & Descriptions:

Name: Polycystic Ovary Syndrome 30 9 11 43 32 60
Polycystic Ovaries 9 43
Pcos 9 41
Polycystic Ovarian Syndrome 41
Polycystic Ovarian Disease 9
 
Stein-Leventhal Syndrome 9
Stein-Leventhal Synd. 9
Multicystic Ovaries 9
Polycystic Ovary 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:11612
ICD9CM27 256.4
MeSH33 D011085
NCIt38 C26862
ICD1025 E28.2

Related Diseases for Polycystic Ovary Syndrome

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Diseases in the Polycystic Ovary Syndrome family:

Polycystic Ovary Syndrome 1

Diseases related to Polycystic Ovary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 231)
idRelated DiseaseScoreTop Affiliating Genes
1acne31.5SHBG
2premature ovarian failure31.2BMP15, AMH, GDF9, GNRH1
3liver disease31.1LEP, INS
4ovarian hyperstimulation syndrome31.1FSHB, GNRH1
5rabson-mendenhall syndrome31.1INS
6hyperprolactinemia31.1GNRH1, SHBG
7cushing's syndrome30.8SULT2A1, INS
8precocious puberty30.8GNRH1, SHBG, AMH, LEP
9acanthosis nigricans30.8INS, SHBG, ADIPOQ, LEP
10congenital adrenal hyperplasia30.7CYP17A1, GNRH1, CYP11A1
11adrenal adenoma30.7SULT2A1, CYP11A1, CYP17A1
12turner syndrome30.7BMP15, IGFBP1, SHBG
13pseudohermaphroditism30.7AMH, CYP17A1
14fatty liver disease30.6RETN, LEP, INS, RBP4
15ovarian disease30.5IGFBP1, GNRH1, SHBG
16endometrial cancer30.5IGFBP1, FST, GNRH1, CYP17A1
17amenorrhea30.5SULT2A1, AMH, SHBG, GNRH1, LEP, INS
18anovulation30.5LEP, INS, IGFBP1, GNRH1, SHBG, AMH
19pituitary tumors30.4FSHB, GHRL, GNRH1, FST
20obstructive sleep apnea30.4ADIPOQ, LEP
21morbid obesity30.4INS, LEP, GHRL
22eating disorder30.4RETN, GHRL, LEP
23vascular disease30.2RETN, ADIPOQ, INS
24hyperinsulinism30.1SHBG, GNRH1, LEP, INS, IGFBP1, SULT2A1
25obesity30.1LEP, INS, CYP11A1, IGFBP1, RBP4, CAPN10
26proteinuria30.0RBP4, ADIPOQ, INS
27hypoglycemia30.0GHRL, IGFBP1, INS, GNRH1
28coronary artery disease30.0GHRL, RETN, ADIPOQ, INS, IGFBP1
29lipodystrophy29.9INS, RETN, ADIPOQ, LEP
30hypothyroidism29.9SHBG, LEP, RETN, INS, GNRH1, GHRL
31hyperandrogenism29.9SULT2A1, IGFBP1, CYP17A1, CYP11A1, INS, LEP
32pituitary adenoma29.8GNRH1, LEP, GHRL, FSHB, FST
33hyperglycemia29.7INS, RETN, LEP, IGFBP1, ADIPOQ, GHRL
34glucose intolerance29.7ADIPOQ, LEP, INS, IGFBP1, CAPN10, GHRL
35atherosclerosis29.5ADIPOQ, LEP, RETN, GHRL, INS, CAPN10
36hypogonadism29.4GHRL, FSHB, INS, LEP, SHBG, ADIPOQ
37infertility29.4CAPN10, BMP15, RETN, FSHB, GDF9, IGFBP1
38anorexia nervosa29.3SHBG, IGFBP1, LEP, ADIPOQ, GHRL, RETN
39adenoma29.3CYP11A1, CYP17A1, INS, IGFBP1, GNRH1, SHBG
40endometriosis29.3FST, CYP17A1, CYP11A1, GNRH1, ADIPOQ, IGFBP1
41acromegaly29.0IGFBP1, INS, LEP, GNRH1, SHBG, ADIPOQ
42breast cancer28.6RBP4, IGFBP1, SULT2A1, AMH, SHBG, GNRH1
43endotheliitis10.8
44insulin-like growth factor i10.7
45thyroiditis10.7
46blindness10.6
47polycystic ovary syndrome 110.5
48hermaphroditism10.5AMH
49hepatitis10.5
50fowler's syndrome10.5

Graphical network of the top 20 diseases related to Polycystic Ovary Syndrome:



Diseases related to polycystic ovary syndrome

Symptoms for Polycystic Ovary Syndrome

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Drugs & Therapeutics for Polycystic Ovary Syndrome

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Drug clinical trials:

Search ClinicalTrials for Polycystic Ovary Syndrome

Search NIH Clinical Center for Polycystic Ovary Syndrome

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Polycystic Ovary Syndrome

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Anatomical Context for Polycystic Ovary Syndrome

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MalaCards organs/tissues related to Polycystic Ovary Syndrome:

31
Ovary, Heart, Skin, Adrenal gland, Endothelial, Adipocyte, Testes, Thyroid, Pituitary, Liver, Bone, Skeletal muscle, Brain, Monocytes, Prostate, Breast, Eye, Whole blood, Cortex, Kidney, Pancreas, Placenta, Tongue, Adrenal cortex, Neutrophil

Animal Models for Polycystic Ovary Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Polycystic Ovary Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.2INS, LEP, ADIPOQ, RETN, GHRL, CAPN10
2MP:00053707.9IGFBP1, INS, LEP, GNRH1, ADIPOQ, RETN
3MP:00053697.7RBP4, FST, ADIPOQ, LEP, INS, CYP11A1
4MP:00053896.3GDF9, CYP17A1, CYP11A1, INS, LEP, GNRH1
5MP:00053795.7RBP4, GDF9, CYP11A1, INS, LEP, GNRH1
6MP:00053765.3GNRH1, LEP, INS, CYP11A1, CYP17A1, GDF9

Publications for Polycystic Ovary Syndrome

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Articles related to Polycystic Ovary Syndrome:

(show top 50)    (show all 2002)
idTitleAuthorsYear
1
Personality profile in patients with polycystic ovary syndrome. (25884894)
2015
2
A possible role of polycystic ovary syndrome for pregnancy complications in women with psoriasis. (25381981)
2014
3
How medical treatment affects mean platelet volume as a cardiovascular risk marker in polycystic ovary syndrome? (25402193)
2014
4
Association of serum pigment epithelium-derived factor with high-sensitivity C-reactive protein in women with polycystic ovary syndrome. (24105071)
2013
5
Ovulation induction in the management of anovulatory polycystic ovary syndrome. (23084977)
2013
6
Cardiovascular disease in polycystic ovary syndrome. (23362921)
2013
7
TNF-I+ haplotype association with polycystic ovary syndrome - a South Indian study. (23975191)
2013
8
Obesity, adipokines and metabolic syndrome in polycystic ovary syndrome. (24002404)
2013
9
To what extent does the use of the Rotterdam criteria affect the prevalence of polycystic ovary syndrome? A community-based study from the Southwest of Iran. (24411130)
2013
10
Associations of adiponectin gene polymorphisms with polycystic ovary syndrome: a meta-analysis. (22270872)
2012
11
Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome. (21717173)
2011
12
Increased plasma metastin levels in adolescent women with polycystic ovary syndrome. (20022159)
2010
13
Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. (20378617)
2010
14
Insulin resistance and overweight-obese women with polycystic ovary syndrome. (19903118)
2010
15
Fibrillins in adult human ovary and polycystic ovary syndrome: is fibrillin-3 affected in PCOS? (20855553)
2010
16
Decreased adiponectin levels in polycystic ovary syndrome, independent of body mass index. (19929617)
2010
17
Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors. (19131059)
2010
18
Obesity and polycystic ovary syndrome. (20054201)
2009
19
Effect of sibutramine on weight reduction and insulin resistance in women with polycystic ovary syndrome. (19362719)
2009
20
Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome? (19094071)
2009
21
Correlates of increased lean muscle mass in women with polycystic ovary syndrome. (19605540)
2009
22
The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes. (19625203)
2009
23
Plasminogen activator and plasma activator inhibitor-1 in young women with polycystic ovary syndrome. (18029284)
2008
24
Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic ovary syndrome. (17803698)
2008
25
Regulation of catechol O-methyltransferase expression in granulosa cells: a potential role for follicular arrest in polycystic ovary syndrome. (17612537)
2008
26
Low-density lipoprotein receptor-related protein-5 C/T polymorphism in exon 18 is associated with C peptide and proinsulin levels in control women and patients with polycystic ovary syndrome. (17953969)
2008
27
Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. (17582143)
2007
28
Polycystic ovary syndrome and the single nucleotide polymorphisms of methylenetetrahydrofolate reductase: a pilot observational study. (17454207)
2007
29
A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome. (16764871)
2006
30
Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism. (16603055)
2006
31
The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: a pilot study. (16359551)
2005
32
FEM1A is a candidate gene for polycystic ovary syndrome. (16390781)
2005
33
Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulin-resistant women with polycystic ovary syndrome. (15598674)
2005
34
Subclinical eating disorder, polycystic ovary syndrome- is there any connection between these two conditions through leptin- a twin study. (16570705)
2005
35
What may be the markers of the male equivalent of polycystic ovary syndrome? (15209536)
2004
36
Insulin secretion in women who have polycystic ovary syndrome and carry the Gly972Arg variant of insulin receptor substrate-1 in response to a high-glycemic or low-glycemic carbohydrate load. (15474880)
2004
37
The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome. (15063963)
2004
38
Leptin and its association with polycystic ovary syndrome: a twin study. (15497495)
2004
39
Polycystic ovary syndrome: syndrome XX? (14516934)
2003
40
The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome. (11375796)
2001
41
Metabolic and endocrine consequences of acute suppression of FFAs by acipimox in polycystic ovary syndrome. (11701699)
2001
42
Study on the relationship between a polymorphism of tumor necrosis factor-alpha gene and the pathogenesis of polycystic ovary syndrome]. (11775944)
2000
43
Effect of opioid blockade on insulin and growth hormone (GH) secretion in patients with polycystic ovary syndrome: the heterogeneity of impaired GH secretion is related to both obesity and hyperinsulinism. (9935127)
1999
44
Usefulness of a 12-month treatment with finasteride in idiophathic and polycystic ovary syndrome-associated hirsutism. (10668160)
1999
45
Involvement of growth factors in the pathophysiology of polycystic ovary syndrome. (10065164)
1998
46
The plasminogen activator system in women with polycystic ovary syndrome. (9496335)
1998
47
Role of cytochrome P450c17 in polycystic ovary syndrome. (9922107)
1998
48
The effects of gonadotrophin-releasing hormone agonist on follicular development in patients with polycystic ovary syndrome in an in-vitro fertilization and embryo transfer programme. (7836506)
1994
49
Increased circulating levels of immunoreactive beta-endorphin in polycystic ovary syndrome is not caused by increased pituitary secretion. (1471704)
1992
50
Changes in circulating hormone levels after ovarian wedge resection in patients with polycystic ovary syndrome. (2124095)
1990

Variations for Polycystic Ovary Syndrome

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Expression for genes affiliated with Polycystic Ovary Syndrome

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Search GEO for disease gene expression data for Polycystic Ovary Syndrome.

Pathways for genes affiliated with Polycystic Ovary Syndrome

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Pathways related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Estrogen biosynthesis58
Androstenedione and testosterone biosynthesis and metabolism p.158
10.0SULT2A1, CYP17A1
210.0GNRH1, SHBG
39.5FSHB, GNRH1
4
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.5CYP17A1, INS, LEP
59.4ADIPOQ, INS, CYP11A1
69.0ADIPOQ, INS, LEP, RETN
7
Show member pathways
8.9INS, LEP, FSHB, GHRL
8
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.6ADIPOQ, RETN, LEP, INS, RBP4
98.5CYP11A1, FSHB, INS, CYP17A1, BMP15, GDF9
10
Show member pathways
8.5INS, IGFBP1, LEP, FSHB, GHRL
11
Show member pathways
7.4INS, LEP, RBP4, GHRL, FSHB, FST

Compounds for genes affiliated with Polycystic Ovary Syndrome

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Compounds related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 170)
idCompoundScoreTop Affiliating Genes
1cyproteroneacetate439.3GNRH1, GHRL, INS, SHBG
2acipimox43 2810.2INS, LEP, GHRL, ADIPOQ
3nash439.1ADIPOQ, RETN, LEP, INS
4clomiphene citrate439.1INS, GNRH1, IGFBP1, FSHB, SHBG
5thiazolidinedione439.0INS, LEP, ADIPOQ, CYP17A1, RETN
6orlistat43 59 1211.0LEP, GHRL, INS, ADIPOQ
7octreotide43 59 28 1211.9ADIPOQ, INS, IGFBP1, GNRH1, GHRL
8triiodothyronine438.9IGFBP1, SHBG, SULT2A1, GHRL, RBP4, LEP
911beta-hydroxysteroid438.9CYP11A1, RETN, ADIPOQ, CYP17A1, LEP
10progestin438.8SHBG, IGFBP1, CYP11A1, GNRH1, ADIPOQ, CYP17A1
11triacylglycerol438.7INS, LEP, ADIPOQ, GHRL, RBP4
12tamoxifen43 49 28 1211.7GNRH1, CYP17A1, LEP, SHBG, SULT2A1, AMH
13uric acid43 249.6INS, LEP, ADIPOQ, RETN, RBP4
14carbohydrates438.6IGFBP1, GHRL, ADIPOQ, SHBG, LEP, INS
15nifedipine43 28 49 1211.6ADIPOQ, GNRH1, CYP11A1, CYP17A1, LEP, GHRL
1617-hydroxyprogesterone43 249.6RETN, ADIPOQ, SHBG, GNRH1, CYP11A1, CYP17A1
17epinephrine43 24 1210.6GHRL, SHBG, GNRH1, LEP, INS, IGFBP1
18estrone43 28 24 1211.5SULT2A1, SHBG, LEP, CYP17A1, IGFBP1, GNRH1
19c-peptide438.5IGFBP1, GHRL, RETN, ADIPOQ, LEP, INS
20corticosterone43 59 2410.4LEP, GHRL, IGFBP1, CYP17A1, CYP11A1
21norepinephrine43 24 1210.1INS, RETN, ADIPOQ, SHBG, GNRH1, IGFBP1
22forskolin43 49 1210.1FST, CYP11A1, SULT2A1, RETN, GHRL, CYP17A1
23fatty acid438.0IGFBP1, ADIPOQ, GHRL, RBP4, RETN, LEP
24pioglitazone28 43 49 1210.9RBP4, ADIPOQ, SHBG, LEP, RETN, GHRL
25arginine437.9LEP, GNRH1, CAPN10, GHRL, ADIPOQ, INS
26rosiglitazone28 43 49 24 1211.9CYP17A1, IGFBP1, INS, LEP, RBP4, GHRL
27thyroxine43 248.8IGFBP1, INS, LEP, GNRH1, SHBG, ADIPOQ
28dhea437.7GHRL, IGFBP1, RETN, ADIPOQ, SULT2A1, SHBG
29vitamin a43 24 129.7RBP4, IGFBP1, CYP17A1, LEP, ADIPOQ, FST
30lactate437.6ADIPOQ, GNRH1, INS, SHBG, IGFBP1, RBP4
31ribonucleic acid437.6CYP17A1, CYP11A1, RBP4, GHRL, FST, GDF9
32metformin43 49 129.6IGFBP1, GHRL, RETN, ADIPOQ, SHBG, GNRH1
33dihydrotestosterone43 28 24 1210.6ADIPOQ, SHBG, GNRH1, LEP, CYP11A1, FST
34actinomycin d437.4RETN, FSHB, FST, ADIPOQ, CYP11A1, IGFBP1
35dehydroepiandrosterone sulfate437.3IGFBP1, CYP17A1, CYP11A1, RBP4, GHRL, ADIPOQ
36adenylate437.3FST, RBP4, GHRL, FSHB, ADIPOQ, SHBG
37cholesterol43 28 24 1210.1RBP4, IGFBP1, CYP17A1, CYP11A1, INS, LEP
38lipid437.1RETN, CYP17A1, CYP11A1, INS, IGFBP1, GHRL
39glucose437.0SHBG, FST, RETN, ADIPOQ, GHRL, CAPN10
40androstenedione43 248.0RBP4, FST, ADIPOQ, SHBG, GNRH1, LEP
41gnrh437.0GNRH1, SHBG, FSHB, GHRL, LEP, INS
42creatinine436.9SHBG, INS, GHRL, FST, ADIPOQ, GNRH1
43acth436.8LEP, INS, CYP11A1, GNRH1, SHBG, SULT2A1
44cysteine436.8IGFBP1, RBP4, CAPN10, RETN, FSHB, FST
45steroid436.6RBP4, GNRH1, CYP11A1, FSHB, SULT2A1, SHBG
46dexamethasone43 49 28 129.2GNRH1, SHBG, SULT2A1, ADIPOQ, FST, RETN
47progesterone43 28 59 24 1210.1RBP4, AMH, SULT2A1, FST, FSHB, RETN
48estradiol43 24 128.0IGFBP1, CYP17A1, CYP11A1, LEP, GNRH1, SHBG
49estrogen435.3IGFBP1, CYP17A1, CYP11A1, RBP4, GHRL, RETN
50testosterone43 59 24 128.3RBP4, GHRL, RETN, FSHB, FST, ADIPOQ

GO Terms for genes affiliated with Polycystic Ovary Syndrome

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Cellular components related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:003477410.0GHRL, INS
2extracellular spaceGO:00056156.8GHRL, BMP15, RETN, ADIPOQ, AMH, GNRH1
3extracellular regionGO:00055765.7RBP4, IGFBP1, GHRL, FSHB, FST, ADIPOQ

Biological processes related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1response to fungicideGO:006099210.2CYP17A1, CYP11A1
2negative regulation of feeding behaviorGO:0200025210.2RETN, INS
3dibenzo-p-dioxin metabolic processGO:001889410.2CYP17A1, CYP11A1
4biphenyl metabolic processGO:001887910.2CYP17A1, CYP11A1
5phthalate metabolic processGO:001896310.2CYP17A1, CYP11A1
6phenol-containing compound metabolic processGO:001895810.2CYP17A1, CYP11A1
7response to insecticideGO:001708510.2CYP17A1, CYP11A1
8cellular response to antibioticGO:007123610.1CYP11A1, CYP17A1
9positive regulation of insulin receptor signaling pathwayGO:004662810.0INS, LEP
10steroid metabolic processGO:000820210.0SULT2A1, CYP11A1, CYP17A1
11sex differentiationGO:000754810.0AMH, CYP17A1
12Leydig cell differentiationGO:003332710.0CYP11A1, CYP17A1
13adult feeding behaviorGO:000834310.0LEP, GHRL
14positive regulation of insulin secretionGO:003202410.0RBP4, CAPN10, GHRL
15negative regulation of gluconeogenesisGO:004572110.0INS, ADIPOQ
16sterol metabolic processGO:00161259.9CYP11A1, CYP17A1
17response to vitamin EGO:00331979.9LEP, CYP11A1
18positive regulation of glucose importGO:00463269.9INS, ADIPOQ, CAPN10
19positive regulation of cellular protein metabolic processGO:00322709.9INS, ADIPOQ
20progesterone biosynthetic processGO:00067019.8FSHB, CYP11A1
21female gamete generationGO:00072929.7BMP15, FSHB, GDF9
22response to insulinGO:00328689.7LEP, RETN, RBP4
23glucose homeostasisGO:00425939.6INS, ADIPOQ, RBP4
24response to ethanolGO:00454719.5GNRH1, ADIPOQ, RBP4
25xenobiotic metabolic processGO:00068059.4SULT2A1, CYP11A1, CYP17A1
26female pregnancyGO:00075659.4FSHB, GNRH1, LEP
27glucose metabolic processGO:00060069.4GHRL, ADIPOQ, LEP, INS
28cellular protein metabolic processGO:00442678.9GHRL, FSHB, INS, IGFBP1
29positive regulation of cell proliferationGO:00082848.8GDF9, INS, LEP, FSHB

Molecular functions related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.5BMP15, ADIPOQ, GDF9
2growth factor activityGO:00080839.0GDF9, LEP, AMH, BMP15
3hormone activityGO:00051797.7RETN, FSHB, ADIPOQ, AMH, GNRH1, LEP

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