Polycythemia malady

Wikipedia: Polycythemia (also known as polycythaemia or polyglobulia) is a disease state in which the proportion of...⁴⁴ more...

MalaCards: Polycythemia, also known as polycythemia, nos, is related to polycythemia vera and essential thrombocythemia. An important gene associated with Polycythemia is CD177 (CD177 molecule), and among its related pathways are Development_Thrombopoetin signaling via JAK-STAT pathway and Development_EPO-induced Jak-STAT pathway. The compounds ag-1296 and hirudin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and kidney, and related mouse phenotypes are respiratory system and renal/urinary system.

Aliases & Descriptions:

polycythemia 6 7 8 32 43 polycythemia, nos 6

erythrocythemia 6 polycythaemia 6

Diseases related to polycythemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 884)

id	Related Disease	Score	Top Affiliating Genes
1	polycythemia vera	36.5	PICALM, PIK3CG, KIT, KITLG, VWF, SELP
2	essential thrombocythemia	36.4	MPL, JAK2, THPO
3	myelofibrosis	34.9	JAK2, CD177, HMGA2, THPO, EPO
4	primary polycythemia	34.1	EGLN1, SOCS2, SOCS3, EPAS1, EPO, EPOR
5	erythrocytosis	33.5	KITLG, SELP, VHL, BCL2L1, MPL, JAK2
6	acquired polycythemia	33.2	JAK2, EPO, EPOR
7	erythremia	31.2	HBA1, HBB, EPO
8	myeloproliferative disorder	30.8	KIT, KITLG, VWF, SELP, BCR, MPL
9	thrombocytosis	30.6	KITLG, VWF, SELP, SERPINC1, VEGFA, MPL
10	thrombosis	29.7	PIK3CG, VWF, SELP, SERPINC1, SERPINE1, VHL
11	portal vein thrombosis	28.2	SELP, SERPINC1, SERPINE1, JAK2, IFNA1, IFNA2
12	pyelonephritis	28.2	CD79A, IL6, CRP, ACE, TIMP1, TF
13	hemangioblastoma	28.2	VHL, VEGFA, CD34, HBA1, HIF1A, TIMP1
14	heparin-induced thrombocytopenia	28.1	SELP, SERPINC1, SERPINE1, CD79A, ITGA2, ITGB3
15	thromboembolism	28.0	VWF, SELP, SERPINC1, SERPINE1, ITGA2, F5
16	venous thrombosis	28.0	VWF, SELP, SERPINC1, SERPINE1, JAK2, ITGAM
17	hemoglobinopathy	27.7	G6PD, HBA2, HBB, HFE, TF, TFRC
18	thrombophilia	27.7	VWF, SELP, SERPINC1, SERPINE1, JAK2, ITGB3
19	chronic obstructive pulmonary disease	27.2	MPO, ITGAM, IL6, PTGS1, SRC, NR3C1
20	hemochromatosis	27.2	HFE, TF, TFRC, HAMP
21	chronic myeloproliferative disease	27.1	VEGFA, BCAM, MPL, MPO, JAK2, CD177
22	immunodeficiency	26.5	BCR, CD79A, CDKN3, ITGB2, IL6, FASLG
23	hypogonadism	26.0	SERPINC1, SERPINE1, FTH1, FTL, IL6, IGFBP1
24	hepatitis	25.9	SELP, FASLG, FAS, IFNA1, IFNA2, F2
25	disseminated intravascular coagulation	25.8	VWF, SERPINC1, SERPINE1, VEGFA, MPO, IL11
26	hemangioma	25.7	KITLG, VWF, VHL, VEGFA, CD34, CDKN3
27	seminoma	25.7	KIT, KITLG, RARB, FASLG, FAS, IDH1
28	splenomegaly	25.6	VEGFA, MPL, JAK2, ITGB2, FASLG, FAS
29	pulmonary hypertension	25.5	VWF, SELP, SERPINC1, SERPINE1, VEGFA, BCL2L1
30	pheochromocytoma	24.5	KIT, SERPINE1, VHL, VEGFA, MLN, IL6
31	renal carcinoma	24.4	PIK3CG, SELP, VHL, VEGFA, BCR, FTH1
32	renal cell carcinoma	23.9	KIT, SELP, VHL, VEGFA, RARB, BCL2L1
33	homocysteine	23.2	PIK3R1, VWF, SELP, SERPINC1, SERPINE1, VHL
34	hematopoiesis	22.7	PIK3R1, PIK3CG, KIT, KITLG, VEGFA, BOK
35	thrombocytopenia	22.0	KITLG, VWF, SELP, SERPINC1, SERPINE1, MPL
36	glomerulonephritis	22.0	KIT, KITLG, VWF, SELP, SERPINC1, SERPINE1
37	hypertension	20.6	PIK3R1, PIK3CG, KIT, VWF, SELP, SERPINC1
38	acute myeloid leukemia	20.4	PIK3R2, PIK3R1, PICALM, PIK3CG, KIT, KITLG
39	pulmonary disease	19.2	PIK3CG, VWF, SELP, SERPINC1, SERPINE1, VEGFA
40	myeloid leukemia	19.2	PIK3R2, PIK3R1, PICALM, PIK3CG, KIT, KITLG
41	hypoxia	19.2	PIK3R1, PIK3CG, KIT, KITLG, VWF, SELP
42	anemia	18.0	KIT, KITLG, VWF, SELP, SERPINC1, VHL
43	cerebritis	17.8	PIK3R1, PIK3CG, KITLG, VWF, SELP, SERPINC1
44	carcinoma	17.1	PIK3R2, PIK3R1, PIK3CG, KIT, KITLG, VWF
45	hepatocellular carcinoma	16.7	PIK3R1, PIK3CG, KIT, VWF, SELP, SERPINC1
46	sm-ahnmd	14.3	KIT, KITLG, JAK2, IFNA2, PDGFRA, PDGFRB
47	hemorrhagic thrombocythemia	14.2	MPL, JAK2, CD177, THPO
48	aggressive systemic mastocytosis	14.2	KIT, KITLG, IFNA2, STAT5A
49	leukemia	14.1	PIK3R2, PIK3R1, PICALM, PIK3CG, KIT, KITLG
50	autoimmune thrombocytopenic purpura	14.1	VWF, MPL, ITGB3, IL11, PF4, THPO

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to polycythemia:

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MGI Mouse Phenotypes related to polycythemia:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.6	EPAS1, SOCS2, PTPN6, CBFB, ALPL, ITGB3
2	renal/urinary system phenotype	MP:0005367	10.1	NPPA, SOCS2, PRKG1, HIF1A, HBB, SELP
3	liver/biliary system phenotype	MP:0005370	9.8	RXRB, PICALM, TET2, CBFB, IGFBP1, IL6
4	other phenotype	MP:0005395	9.8	CSF2, CSF1, STAT3, HBB, PDGFRA, PTGS1
5	embryogenesis phenotype	MP:0005380	9.7	EPOR, EPAS1, CSF2, ALPL, F2, MLLT3
6	endocrine/exocrine gland phenotype	MP:0005379	9.6	RXRB, PTPN6, PTS, HMGA2, ETV6, CASP8
7	hematopoietic system phenotype	MP:0005397	9.4	CSF3, CSF2, PRKG1, TFRC, THPO, TYK2
8	craniofacial phenotype	MP:0005382	9.1	RXRB, PDGFRA, PDGFRB, EDN1, CSF1, CSF2
9	adipose tissue phenotype	MP:0005375	8.8	PDGFRB, ACE, STAT3, STAT5A, SOCS2, SOCS3
10	limbs/digits/tail phenotype	MP:0005371	8.8	PTPN6, SRC, CRABP2, PDGFRA, HFE, STAT1
11	reproductive system phenotype	MP:0005389	8.5	CSF1, PRM2, PRKG1, STAT5A, STAT3, TIMP1
12	behavior/neurological phenotype	MP:0005386	8.4	ABL1, PDGFRA, RXRB, PLAUR, NR3C1, SRC
13	vision/eye phenotype	MP:0005391	8.4	CBFB, SRC, RXRB, PDGFRB, ABL1, HIF1A
14	tumorigenesis	MP:0002006	8.2	CSF2, TNFSF10, HRAS, ETV6, F3, IGF1
15	digestive/alimentary phenotype	MP:0005381	8.1	PTPN6, BCAM, RARB, VEGFA, VHL, VWF
16	normal phenotype	MP:0002873	7.9	HFE, HIF1A, HBB, ABL1, PDGFRA, RXRB
17	integument phenotype	MP:0010771	7.8	BCL2L1, VHL, SELP, KITLG, KIT, PIK3CG
18	skeleton phenotype	MP:0005390	7.7	MLLT3, PIK3CG, ITGB3, ITGB2, JAK2, LAMA5
19	immune system phenotype	MP:0005387	7.6	CD34, PICALM, CD79A, FTH1, MPL, LAMA5
20	nervous system phenotype	MP:0003631	7.0	PROS1, STAT1, STAT3, THBD, HIF1A, HBB
21	muscle phenotype	MP:0005369	6.6	ABL1, EGLN1, EDN1, PDGFRB, PDGFRA, PLAUR
22	growth/size phenotype	MP:0005378	6.5	HAMP, SLC2A1, CSF2, SOCS3, SOCS2, STAT1
23	mortality/aging	MP:0010768	5.7	KITLG, PICALM, G6PD, PTPN6, PTS, TET2
24	cellular phenotype	MP:0005384	5.2	STAT1, STAT5A, STAT3, TFRC, THBD, TYK2
25	cardiovascular system phenotype	MP:0005385	4.1	F3, MPO, LAMA5, BCAM, RARB, VEGFA
26	homeostasis/metabolism phenotype	MP:0005376	3.2	EPO, EPAS1, HAMP, SLC2A1, NPPA, CSF2

Articles related to polycythemia:

(show top 50)    (show all 298)

id	Title	Authors	Year	Affiliating Genes
1	Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes. (21712540)	Stein B.L.... Moliterno A.R.	2011	ASXL1
2	IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. (20508616)	Tefferi A.... Vannucchi A.M.	2010	JAK2, IDH1, MPL
3	Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia. (19336760)	Sulahian R.... Huang L.J.	2009	JAK2, PIK3R1, EPOR
4	The polycythemia vera-associated Jak2 V617F mutant in duces tumorigenesis in nude mice. (19327411)	Abe M.... Kasahara T.	2009	JAK2
5	Emerging drugs for the therapy of primary and post es sential thrombocythemia, post polycythemia vera myelofibrosis. (19552608)	Mesa R.A.... Tefferi A.	2009	JAK2
6	Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations. (18195094)	Li S.... Skoda R.C.	2008	JAK2
7	Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. (18394555)	Geron I.... Jamieson C.H.	2008	JAK2
8	Cytogenetic studies at diagnosis in polycythemia vera: clinical and JAK2V617F allele burden correlates. (18081705)	Gangat N.... Tefferi A.	2008	JAK2
9	Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera. (18650451)	Kiladjian J.J.... Fenaux P.	2008	IFNA1
10	Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24,577 first-degree relatives of 11,039 patients with myeloproliferative neoplasms in Sweden. (18451307)	Landgren O.... BjAPrkholm M.	2008	BCR
11	JAK2 V617F mutation testing in polycythemia vera: use and impact in an academic practice. (18854675)	Means R.T.	2008	JAK2
12	Risk of thrombosis in patients with essential thrombocythemia and polycythemia vera according to JAK2 V617F mutation status. (17229651)	Finazzi G.... Barbui T.	2007	JAK2
13	Phenotypic variations and new mutations in JAK2 V617F-negative polycythemia vera, erythrocytosis, and idiopathic myelofibrosis. (17920755)	Williams D.M.... Moliterno A.R.	2007	JAK2, MPL
14	JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. (17267906)	Scott L.M.... Green A.R.	2007	JAK2
15	Polycythemia vera is not initiated by JAK2V617F mutation. (17198871)	Nussenzveig R.H.... Prchal J.T.	2007	JAK2
16	A new JAK2 gene mutation in patients with polycythemia vera and splanchnic vein thrombosis. (17881638)	Colaizzo D.... Margaglione M.	2007	JAK2
17	Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis. (16954506)	Delhommeau F.... Giraudier S.	2007	JAK2
18	Limited effects on JAK2 mutational status after pegylated interferon alpha-2b therapy in polycythemia vera and essential thrombocythemia. (16956836)	Samuelsson J.... Pahl H.L.	2006	JAK2, IFNA2
19	Overexpression of PRV-1 gene in polycythemia rubra vera and essential thrombocythemia. (16502591)	Martini M.... Larocca L.M.	2006	CD177
20	Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. (17183644)	Zaleskas V.M.... Van Etten R.A.	2006	JAK2, FGR, EPO
21	Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia. (16772604)	Scott L.M.... Green A.R.	2006	JAK2
22	Absence of mutations of the EPO-receptor gene in Greek patients with familial polycythemia. (16608505)	Bourantas L.K.... Georgiou I.	2006	EPOR
23	JAK2V617F mutational frequency in polycythemia vera: 100%, >90%, less? (16990780)	Verstovsek S.... Tefferi A.	2006	JAK2
24	Clinical and laboratory features, pathobiology of platelet-mediated thrombosis and bleeding complications, and the molecular etiology of essential thrombocythemia and polycythemia vera: therapeutic implications. (16673274)	Michiels J.J.... Schroyens W.	2006	JAK2, THBD, PPBP
25	Secondary polycythemia caused by ureteropelvic junction obstruction successfully treated by laparoscopic nephrectomy. (16750248)	Madeb R.... Erturk E.	2006	EPO
26	A Unique Activating Mutation in JAK2 (V617F) Is at the Origin of Polycythemia Vera and Allows a New Classification of Myeloproliferative Diseases. (16304380)	Vainchenker W.... Constantinescu S.N.	2005	JAK2, BCR
27	Role of tyrosine kinases and phosphatases in polycythemia vera. (16210035)	Zhao Z.J.... Constantinescu S.N.	2005	JAK2, PTS, CDKN3
28	The effects of hydroxyurea on PRV-1 expression in patients with essential thrombocythemia and polycythemia vera. (15477215)	Johansson P.... Andreasson B.	2004	CD177
29	Analysis of hemochromatosis gene mutations in 52 consecutive patients with polycythemia vera. (15763983)	Franchini M.... Veneri D.	2004	HFE
30	Mutations in the VHL gene in sporadic apparently congenital polycythemia. (12393546)	Pastore Y.D.... Prchal J.T.	2003	VHL, EPO
31	Factor V Leiden mutation carriership and venous thromboembolism in polycythemia vera and essential thrombocythemia. (12221665)	Ruggeri M.... Rodeghiero F.	2002	F5
32	STAT3 is constitutively active in some patients with Polycythemia rubra vera. (11378264)	RAPder S.... Pahl H.L.	2001	STAT3
33	Evaluation of diagnostic criteria in polycythemia ver a. (11242598)	Pearson T.C.	2001	EPO
34	Increased cell surface expression of C-terminal truncated erythropoietin receptors in polycythemia. (11722595)	Motohashi T.... Nakauchi H.	2001	EPOR, EPO
35	The value of bone marrow histology in differentiating between early stage Polycythemia vera and secondary (reactive) Polycythemias. (11325641)	Thiele J.... Diehl V.	2001	EPO, PICALM
36	Diagnosis and treatment of polycythemia vera and possible future study designs of the PVSG. (10674896)	Michiels J.J.... Thiele J.	2000	IFNA1
37	Immunohistochemical staining for megakaryocyte c-mpl may complement morphologic distinction between polycythemia vera and secondary erythrocytosis. (10887148)	Tefferi A.... Li C.Y.	2000	MPL
38	Posttranslational processing of the thrombopoietin receptor is impaired in polycythemia vera. (10515857)	Moliterno A.R.... Spivak J.L.	1999	MPL, MMRN1
39	End-stage renal disease following polycythemia vera: in vitro and in vivo response of erythroid progenitors to erythropoietin and effects of sera on normal erythropoiesis. (9647492)	SHIH L.Y.... Huang J.Y.	1998	EPO
40	Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia. (9649565)	Kralovics R.... Prchal J.T.	1998	EPOR, EPO
41	Polycythemia vera treated with recombinant interferon-alpha 2a: evidence of a selective effect on the malignant clone. (9326356)	Massaro P.... Maiolo A.T.	1997	IFNA2
42	Polycythemia vera. V. Enhanced proliferation and phosphorylation due to vanadate are diminished in polycythemia vera erythroid progenitor cells: a possible defect of phosphatase activity in polycythemia vera. (9160662)	Dai C.H.... Sawyer S.T.	1997	KITLG, ACP1, EPO
43	Role of interferon alpha-2a in the treatment of polycythemia vera. (7832194)	Foa P.... Maiolo A.T.	1995	IFNA2, IFNA1
44	Polycythemia as a complication of human immunodeficie ncy virus infection. (8506494)	Edwards T.B.... Lockey R.F.	1993	EPO
45	Morphometric study of the bone marrow in polycythemia vera following interferon-alpha therapy. (8516217)	Franco V.... Campesi G.	1993	IFNA1
46	Familial and congenital polycythemia in three unrelated families. (1316790)	Emanuel P.D.... Prchal J.T.	1992	EPO
47	Further studies of the defective stimulus-response coupling for the oxidative burst in neutrophils in polycythemia vera. (1954981)	Samuelsson J.... Berg A.	1991	LTF
48	Efficacy of recombinant human macrophage colony-stimulating factor in combination with whole-body hyperthermia in the treatment of mice infected with the polycythemia-inducing strain of the Friend virus complex. (1907925)	Lu L.... Broxmeyer H.E.	1991	CSF1
49	A clinical and biological study of 33 cases of polycythemia vera (2236766)	Corredoira J.C.... Arias J.	1990	EPO
50	Polycythemia associated with a hemoglobinopathy. (5913291)	Charache S.... Clegg J.B.	1966	HBA1

Genes related to polycythemia according to GeneCards:

(show top 50)    (show all 143)

id	Symbol	Description	Score	GeneCards Section Context
1	CD177	CD177 molecule	11.1	Publications, Expressions, Aliases & Descriptions, Functions
2	EPO	erythropoietin	11.0	Publications
3	JAK2	Janus kinase 2	11.0	Publications
4	EPOR	erythropoietin receptor	11.0	Publications
5	MPL	myeloproliferative leukemia virus oncogene	11.0	Publications
6	SOCS3	suppressor of cytokine signaling 3	11.0	Publications
7	THPO	thrombopoietin	11.0	Publications
8	STAT5A	signal transducer and activator of transcription 5A	11.0	Publications
9	PTPN6	protein tyrosine phosphatase, non-receptor type 6	11.0	Publications
10	KITLG	KIT ligand	11.0	Publications
11	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	11.0	Publications
12	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
13	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
14	G6PD	glucose-6-phosphate dehydrogenase	11.0
15	SOCS2	suppressor of cytokine signaling 2	11.0	Publications
16	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Publications
17	PF4	platelet factor 4	11.0	Publications
18	CSF3R	colony stimulating factor 3 receptor (granulocyte)	11.0	Publications
19	TYK2	tyrosine kinase 2	11.0	Publications
20	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
21	HMGA2	high mobility group AT-hook 2	11.0	Publications
22	IFNA2	interferon, alpha 2	11.0	Publications
23	ACP1	acid phosphatase 1, soluble	11.0	Publications
24	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
25	JAK1	Janus kinase 1	11.0	Publications
26	IFNA1	interferon, alpha 1	11.0	Publications
27	THBD	thrombomodulin	11.0	Publications
28	BCL2L1	BCL2-like 1	11.0	Publications
29	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
30	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
31	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0
32	FLT3	fms-related tyrosine kinase 3	11.0
33	IGF1R	insulin-like growth factor 1 receptor	11.0	Publications
34	STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	11.0	Publications
35	PRKG1	protein kinase, cGMP-dependent, type I	11.0
36	LUZP6	leucine zipper protein 6	11.0	UniProt Related
37	CST7	cystatin F (leukocystatin)	11.0	Publications
38	MPST	mercaptopyruvate sulfurtransferase	11.0	Publications
39	FAM215A	family with sequence similarity 215, member A (non-protein coding)	11.0	Publications
40	PRM2	protamine 2	11.0	Publications
41	PLVAP	plasmalemma vesicle associated protein	11.0	Publications
42	BOK	BCL2-related ovarian killer	11.0	Publications
43	PTX3	pentraxin 3, long	11.0	Publications
44	HAMP	hepcidin antimicrobial peptide	11.0	Publications
45	DPM1	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit	11.0
46	TET2	tet methylcytosine dioxygenase 2	11.0	Publications
47	IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	11.0	Publications
48	IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	11.0	Publications
49	ACSL6	acyl-CoA synthetase long-chain family member 6	11.0	Publications
50	MMRN1	multimerin 1	11.0	Publications

Pathways related to polycythemia according to GeneDecks:

(show top 50)    (show all 237)

id	Pathway	Score	Top Affiliating Genes
1	Development_Thrombopoetin signaling via JAK-STAT pathway41	10.9	SOCS3, STAT5A, THPO, CRP, PTPN6, JAK2
2	Development_EPO-induced Jak-STAT pathway41	10.9	PTPN6, EPOR, STAT5A, SRC, STAT1, JAK2
3	Immune response Oncostatin M signaling via JAK-Stat in human cells10	10.9	JAK1, SOCS3, STAT5A, STAT3, TIMP1, TYK2
4	Development EPO-induced Jak-STAT pathway10	10.9	STAT1, SRC, PTPN6, HRAS, JAK2, BCL2L1
5	Development Thrombopoetin signaling via JAK-STAT pathway10	10.9	MPL, CRP, STAT3, STAT5A, STAT1, SOCS3
6	Jak-STAT signaling pathway20	10.6	PIK3R2, PIK3R1, PIK3CG, BCL2L1, MPL, JAK1
7	Glioma Invasiveness36	10.6	ITGB2, ITGAM, KITLG, PIK3R2, IL3, PPBP
8	Jak/Stat Pathway3	10.6	JAK1, JAK2, SOCS3, SOCS2, STAT5A, TYK2
9	Ras Pathway36	10.5	HRAS, IGF1R, IL3, FLT3, ITGB3, ITGAM
10	Immune response_IL-10 signaling pathway41	10.4	PIK3R2, PIK3R1, BCL2L1, JAK1, SOCS3, STAT1
11	Immune response IL-10 signaling pathway10	10.4	SOCS3, STAT1, STAT3, PIK3R2, PIK3R1, BCL2L1
12	PPAR Pathway36	10.4	THPO, PDGFRB, PDGFRA, RXRB, PPBP, IGF1
13	Development PDGF signaling via STATs and NF-kB10	10.4	SRC, PDGFRA, PDGFRB, STAT5A, STAT3, TYK2
14	Development_PDGF signaling via STATs and NF-kB41	10.4	STAT1, PIK3R2, STAT5A, STAT3, TYK2, PDGFRB
15	Pancreatic Adenocarcinoma36	10.4	PIK3R2, PPBP, SRC, IGF1, IGF1R, IL6
16	Paxillin Interactions36	10.4	IGF1, IL3, FLT3, ITGB3, ITGB2, ITGAM
17	Immune response_Oncostatin M signaling via JAK-Stat in human cells41	10.4	SOCS3, VEGFA, JAK2, TYK2, STAT3, TIMP1
18	Blood Coagulation Signaling Pathways37	10.3	PROC, VWF, SERPINC1, SERPINE1, GP1BA, F5
19	14-3-3 Induced Intracellular Signaling36	10.2	EPOR, THPO, TIMP1, PDGFRB, PDGFRA, PIK3R2
20	Renin-Angiotensin Pathway36	10.2	HGF, STAT1, STAT3, THPO, TIMP1, TYK2
21	GPCR Pathway36	10.2	TIMP1, PDGFRB, THPO, PDGFRA, PPBP, STAT5A
22	PTEN Pathway36	10.2	PIK3R1, KIT, KITLG, ITGA2, PIK3R2, HGF
23	Rac1 Pathway36	10.1	KITLG, ITGA2, ITGAM, ITGB2, ITGB3, IL3
24	p70S6K Signaling36	10.1	PIK3R1, JAK1, KITLG, JAK2, PDGFRA, KIT
25	MAPK Signaling36	10.1	STAT5A, ITGB2, ITGAM, ITGA2, LAMA5, KIT
26	JAK-STAT Pathway36	10.1	IL3, STAT3, STAT5A, STAT1, SOCS2, SOCS3
27	UPA-UPAR Pathway36	10.0	STAT5A, PIK3R2, ITGB3, ITGB2, ITGAM, STAT3
28	Akt Signaling36	10.0	FLT3, IL11, IL6, IGF1R, PF4, PDGFRA
29	Hematopoietic cell lineage20	10.0	GP1BA, ITGA2, ITGAM, ITGB3, GYPA, TFRC
30	ILK Signaling36	10.0	ITGAM, KIT, EPOR, TIMP1, HIF1A, LAMA5
31	Tec Kinases Signaling36	9.9	EPOR, HGF, CSF3R, STAT1, STAT5A, STAT3
32	p38 Signaling36	9.9	IGF1R, EPOR, HGF, CSF3R, CSF3, CSF2
33	ERK Signaling36	9.9	THPO, STAT1, CSF3, EPOR, TIMP1, PIK3R2
34	Signaling Involved in Cardiac Hypertrophy36	9.8	PDGFRA, PDGFRB, HRAS, STAT3, ITGA2, ITGB3
35	STAT3 Pathway36	9.7	JAK2, IL11, IL3, SOCS3, CSF2, CSF3
36	Apoptotic Pathways in Synovial Fibroblasts36	9.6	PIK3R2, PDGFRB, CASP8, KITLG, IL3, IL6
37	Mitochondrial Apoptosis36	9.6	HGF, KIT, THPO, KITLG, PDGFRA, PPBP
38	Antioxidant Action of Vitamin-C36	9.6	PPBP, TNFSF10, HRAS, IGF1, JAK2, IL6
39	DHA Signaling36	9.5	PDGFRA, KIT, KITLG, BCL2L1, IL3, IL6
40	Rho Family GTPases36	9.5	ITGA2, TIMP1, THPO, CSF1, CSF2, CSF3
41	p53 Mediated Apoptosis36	9.4	TIMP1, THPO, PDGFRB, PPBP, TNFSF10, CASP8
42	eNOS Signaling36	9.3	PIK3R2, PDGFRB, PDGFRA, KIT, THPO, TIMP1
43	Cellular Apoptosis Pathway36	9.3	PPBP, TNFSF10, CASP8, IGF1, IGF1R, IL6
44	IL-6 Pathway36	9.2	STAT3, TIMP1, TNFSF10, SOCS2, SOCS3, CSF1
45	Molecular Mechanisms of Cancer36	9.2	IL3, IL6, IGF1R, CASP8, HRAS, TNFSF10
46	Measles20	9.1	PIK3CG, PIK3R1, PIK3R2, EIF2S1, JAK1, JAK2
47	PAK Pathway36	9.0	PF4, PDGFRA, PDGFRB, TIMP1, THPO, CSF1
48	Endothelin-1 Signaling Pathway36	8.8	PF4, PDGFRA, PDGFRB, EDN1, CSF1, CSF3
49	Cytokine-cytokine receptor interaction20	8.6	CSF1, CSF2, IFNA1, FAS, PPBP, PF4
50	Pathways in cancer20	8.2	BCR, RXRB, PDGFRA, ABL1, HIF1A, STAT3

Compounds related to polycythemia according to GeneDecks:

(show top 50)    (show all 507)

id	Compound	Score	Top Affiliating Genes
1	ag-129632	10.8	PIK3CG, KIT, KITLG, BCL2L1, FLT3, IL3
2	hirudin32	10.7	SERPINC1, GP1BA, F5, PLAUR, PF4, TIMP1
3	citrate32	10.6	SELP, CD79A, CDKN3, PPBP, PF4, LTF
4	adp32 18	11.4	PIK3CG, KIT, VWF, SELP, SERPINC1, BCL2L1
5	ribavirin32 34 9 9	13.1	IL3, IFNA1, IFNA2, LTF, G6PD, TIMP1
6	phenylalanine32	10.1	PIK3R1, BCR, JAK1, JAK2, GP1BA, ALPL
7	atp32	10.0	KIT, BCL2L1, BCR, JAK2, CDKN3, ITGA2
8	n-formylmethionyl-leucylphenylalanine32	9.9	PIK3CG, SELP, LCN2, MPO, ITGAM, ITGB2
9	fmlp32	9.8	PIK3CG, SELP, LCN2, MPO, ITGAM, ITGB2
10	agar32	9.6	PIK3R1, KITLG, RARB, JAK2, CD34, IGF1R
11	desmopressin32 42 9 9	12.6	VWF, SELP, SERPINC1, SERPINE1, GP1BA, F5
12	fibrinogen32	9.5	SELP, SERPINC1, SERPINE1, LCN2, CD79A, ITGA2
13	calcitriol32 42 9 18 9	13.5	KITLG, RARB, ITGAM, FGR, IL11, IL3
14	vitamin b1232	9.5	VWF, MPO, CD79A, IGFBP3, IGF1, F5
15	matrigel32	9.4	PIK3R1, PIK3CG, VWF, SERPINE1, VEGFA, BCL2L1
16	kininogen32	9.4	VWF, SELP, SERPINC1, SERPINE1, MPO, ITGB2
17	ethanol32 34 9 18 9	13.4	KITLG, RARB, MPST, ITGAM, ITGB2, IL11
18	phosphoinositide32	9.3	PIK3R2, PIK3R1, PIK3CG, KIT, BCL2L1, BCR
19	adenylate32	9.3	PIK3CG, KITLG, VWF, SELP, SERPINC1, SERPINE1
20	nitric oxide32 9 18 9	12.3	KIT, KITLG, SELP, VHL, LCN2, MPO
21	pge132	9.2	VWF, SERPINE1, IL11, IL6, F5, F2
22	polysaccharide32	9.2	KITLG, SELP, SERPINC1, CD79A, ITGA2, ITGAM
23	pge232	9.1	FASLG, IGF1R, TNFRSF11B, PTGS1, PPBP, PLAUR
24	thalidomide32 42 9 9	12.1	VEGFA, BCL2L1, ITGB2, IL11, IL6, FASLG
25	tacrolimus32 34 9 9	11.9	SERPINE1, CD79A, CDKN3, IL11, IL3, FASLG
26	histamine32 18	9.8	KIT, KITLG, VWF, SELP, MPO, CD79A
27	cysteine32	8.7	SELP, RARB, BCL2L1, MPL, MPST, CD79A
28	superoxide32 18	9.7	PIK3R1, KITLG, LCN2, MPO, ITGAM, ITGB2
29	herbimycin a32 42	9.6	PIK3CG, KITLG, JAK2, CDKN3, ITGB2, FLT3
30	simvastatin32 34 42 9 18 9	13.6	KITLG, VWF, SELP, SERPINE1, VEGFA, ITGAM
31	cytarabine32 34 9 9	11.5	KIT, KITLG, BCL2L1, BCR, MPO, FLT3
32	doxorubicin32 34 9 9	11.5	PIK3CG, KIT, KITLG, BCL2L1, FLT3, IL11
33	testosterone32 9 18 9	11.3	PIK3R1, KIT, KITLG, SERPINC1, RARB, CD79A
34	vitamin d32	8.2	SERPINE1, RARB, CD79A, ITGAM, ITGB2, ITGB3
35	oxygen32 18	9.2	KITLG, BOK, BCL2L1, BCR, MPO, FTH1
36	cholesterol32 9 18 9	11.1	PIK3R1, KITLG, VWF, SELP, SERPINE1, BCR
37	arginine32	8.1	VWF, SERPINC1, RARB, CD79A, ITGB2, MLN
38	glutamine32	8.0	PIK3CG, KIT, VWF, ITGAM, IL11, IL3
39	sb 20358032 42	9.0	VEGFA, BCL2L1, ITGAM, ITGB2, IL6, IGF1
40	prednisolone32 9 9	9.8	KITLG, VWF, LCN2, MPO, CD79A, CDKN3
41	alanine32	7.8	KITLG, VWF, SERPINC1, MPL, JAK1, JAK2
42	epinephrine32 9 18 9	10.8	KITLG, SELP, JAK2, CD79A, ITGA2, ITGAM
43	cyclosporin a32 42	8.8	PIK3CG, KITLG, VWF, SELP, JAK2, CDKN3
44	5fluorouracil32	7.7	PIK3CG, KIT, KITLG, VEGFA, BCL2L1, MPL
45	calcium32 9 18 9	10.7	KIT, KITLG, VWF, VHL, BCR, LCN2
46	lactate32	7.5	KIT, KITLG, VWF, SELP, MPO, CD79A
47	cisplatin32 34 9 9	9.7	KITLG, VEGFA, RARB, BCL2L1, MPO, JAK2
48	phosphatidylinositol32	6.5	PIK3R2, PIK3R1, PIK3CG, KIT, KITLG, VHL
49	actinomycin d32	6.1	PIK3CG, KIT, KITLG, SERPINE1, VHL, VEGFA
50	dexamethasone32 42 34 9 9	9.7	PIK3R1, KITLG, VWF, SELP, SERPINC1, SERPINE1

Cellular components related to polycythemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.8	HGF, PROS1, TIMP1, PF4, PPBP, F5
2	integral to plasma membrane	GO:005887	9.1	PLAUR, PDGFRA, PDGFRB, HFE, THBD, TFRC
3	external side of plasma membrane	GO:009897	9.0	ACE, FAS, FASLG, ITGA2, CD34, CD79A
4	membrane	GO:016020	8.7	PDGFRB, ACSL6, TYK2, DPM1, TFRC, CSF1
5	perinuclear region of cytoplasm	GO:048471	8.1	CSF1, TF, HFE, ABL1, PLVAP, HRAS
6	cytosol	GO:005829	7.3	HBA2, G6PD, EIF5B, EIF2S1, ABL1, EGLN1
7	extracellular space	GO:005615	7.2	EPO, IGFBP3, IGFBP1, FASLG, IL6, IL3
8	cytoplasm	GO:005737	6.8	EIF4ENIF1, ABL1, EGLN1, EDN1, PDGFRB, PDGFRA
9	plasma membrane	GO:005886	6.4	SRC, PLAUR, PDGFRA, PDGFRB, PTGS1, TNFRSF25
10	extracellular region	GO:005576	6.0	EPOR, EPO, HGF, HAMP, KITLG, IFNA2

Biological processes related to polycythemia according to GeneDecks:

(show top 50)    (show all 53)

id	Name	GO ID	Score	Top Affiliating Genes
1	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	11.0	SOCS3, SOCS2, STAT1, STAT5A, STAT3, PTPN6
2	JAK-STAT cascade	GO:007259	10.9	SOCS3, SOCS2, STAT1, STAT5A, STAT3, JAK2
3	regulation of type I interferon-mediated signaling pathway	GO:060338	10.9	SOCS3, STAT1, TYK2, PTPN6, IFNA2, JAK1
4	regulation of interferon-gamma-mediated signaling pathway	GO:060334	10.9	SOCS3, STAT1, PTPN6, JAK2, JAK1
5	cytokine-mediated signaling pathway	GO:019221	10.9	TYK2, STAT3, STAT5A, STAT1, SOCS3, CSF3
6	type I interferon-mediated signaling pathway	GO:060337	10.9	SOCS3, STAT1, TYK2, PTPN6, HLA-G, IFNA2
7	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	10.8	EPO, CSF2, IGF1, IL3, JAK2, KIT
8	positive regulation of DNA replication	GO:045740	10.8	EPO, CSF2, PDGFRA, HRAS, IGF1, IGF1R
9	peptidyl-tyrosine phosphorylation	GO:018108	10.8	PDGFRA, PDGFRB, ABL1, STAT5A, SRC, PTPN6
10	interferon-gamma-mediated signaling pathway	GO:060333	10.7	SOCS3, STAT1, PTPN6, HLA-G, JAK2, JAK1
11	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	10.7	PDGFRB, PDGFRA, FGR, FLT3, KIT
12	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.6	HGF, PDGFRB, PDGFRA, PTPN6, F2, IGF1
13	fibrinolysis	GO:042730	10.6	PROS1, PLAUR, F2, GP1BA, SERPINE1
14	growth hormone receptor signaling pathway	GO:060396	10.5	SOCS2, STAT3, JAK2, PIK3R1
15	positive regulation of MAPK cascade	GO:043410	10.5	HRAS, IGF1, IGFBP3, IL6, IL11, FLT3
16	protein autophosphorylation	GO:046777	10.5	EIF2S1, PDGFRB, PDGFRA, IGF1R, FGR, FLT3
17	positive regulation of Ras protein signal transduction	GO:046579	10.4	EPO, CSF1, IGF1, KITLG
18	cell chemotaxis	GO:060326	10.4	KIT, PDGFRA, PDGFRB, HGF
19	integrin-mediated signaling pathway	GO:007229	10.4	FGR, LAMA5, ITGA2, ITGAM, ITGB2, ITGB3
20	cell adhesion	GO:007155	10.4	MMRN1, GP1BA, F5, SRC, ABL1, CSF3R
21	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061418	10.3	EPO, EPAS1, HIF1A, EGLN1, VEGFA, VHL
22	iron ion transport	GO:006826	10.3	HFE, LTF, FTL, FTH1
23	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:038091	10.3	PDGFRB, PDGFRA, VEGFA
24	embryonic hemopoiesis	GO:035162	10.2	HIF1A, IL3, KITLG, KIT
25	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.2	HGF, IGF1, IL6, IL3, IL11, ITGB3
26	cell proliferation	GO:008283	10.1	CSF1, STAT3, THPO, PTPN6, HRAS, CD34
27	negative regulation of apoptotic process	GO:043066	10.1	EPO, CSF2, PROC, TIMP1, PF4, PLAUR
28	cellular response to stress	GO:033554	10.1	EPO, EPAS1, HIF1A, EGLN1, FASLG, VEGFA
29	cellular iron ion homeostasis	GO:006879	10.1	HAMP, TFRC, TF, HFE, HIF1A, FTL
30	cellular response to hypoxia	GO:071456	10.0	EPO, EPAS1, HIF1A, EGLN1, VEGFA, VHL
31	leukocyte migration	GO:050900	10.0	PROC, PROS1, PIK3R2, PIK3R1, SELP, CD34
32	phosphatidylinositol-mediated signaling	GO:048015	10.0	PDGFRB, PDGFRA, IGF1, IGF1R, PIK3R1, PIK3R2
33	immune response	GO:006955	9.8	HAMP, CST7, CSF3, CSF2, HFE, PF4
34	platelet degranulation	GO:002576	9.8	MMRN1, ITGB3, VEGFA, SERPINE1, SELP, IGF1
35	aging	GO:007568	9.8	EPO, SOCS3, SOCS2, TIMP1, NR3C1, PTGS1
36	negative regulation of blood coagulation	GO:030195	9.8	PROC, THBD, EDN1, CD34, SERPINE1
37	positive regulation of smooth muscle cell proliferation	GO:048661	9.7	STAT1, HIF1A, EDN1, PDGFRB, IGF1, IL6
38	positive regulation of gene expression	GO:010628	9.7	CSF2, CSF1, PF4, PLAUR, HMGA2, CD34
39	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.7	HMGA2, RXRB, HIF1A, STAT3, STAT5A, STAT1
40	anti-apoptosis	GO:006916	9.7	EPO, HGF, SOCS3, SOCS2, NR3C1, F3
41	positive regulation of MAP kinase activity	GO:043406	9.5	EDN1, PDGFRB, FLT3, VEGFA, KITLG, PIK3CG
42	positive regulation of cell migration	GO:030335	9.1	CSF1, EDN1, PDGFRB, PDGFRA, F3, IGF1R
43	platelet activation	GO:030168	9.1	PIK3R2, PIK3R1, PIK3CG, F5, F2, SRC
44	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.0	TNFSF10, CASP8, F3, FAS, FASLG, JAK2
45	positive regulation of cell proliferation	GO:008284	8.7	JAK2, PDGFRB, EDN1, TIMP1, THPO, CSF1
46	blood coagulation	GO:007596	8.7	PIK3R2, ITGAM, ITGB2, ITGB3, MMRN1, FGR
47	response to lipopolysaccharide	GO:032496	8.6	EPO, SOCS3, THPO, THBD, EDN1, CASP8
48	apoptotic process	GO:006915	8.5	HRAS, TNFRSF11B, TNFRSF25, TNFSF10, PTPN6, ABL1
49	signal transduction	GO:007165	8.5	PLAUR, CRABP2, NR3C1, SRC, TNFSF10, PDGFRB
50	response to hypoxia	GO:001666	8.3	EPAS1, SOCS3, HIF1A, EGLN1, EDN1, CRP

Molecular functions related to polycythemia according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	growth hormone receptor binding	GO:005131	10.8	SOCS2, TYK2, JAK2, JAK1
2	protein tyrosine kinase activity	GO:004713	10.5	TYK2, ABL1, PDGFRB, SRC, IGF1R, FGR
3	non-membrane spanning protein tyrosine kinase activity	GO:004715	10.4	TYK2, ABL1, SRC, FGR, JAK2, JAK1
4	peroxidase activity	GO:004601	10.3	MPO, PTGS1, HBA2, HBB
5	ferric iron binding	GO:008199	9.9	TF, LTF, FTL, FTH1
6	platelet-derived growth factor receptor binding	GO:005161	9.9	VEGFA, ITGB3, PDGFRA, PDGFRB
7	growth factor activity	GO:008083	9.5	HGF, CSF3, CSF2, CSF1, THPO, PPBP
8	alkaline phosphatase activity	GO:004035	9.5	ALPPL2, ALPP, ALPL
9	receptor binding	GO:005102	9.2	NPPA, PDGFRB, SRC, TNFSF10, HLA-G, F2
10	protein homodimerization activity	GO:042803	9.2	PLVAP, PDGFRA, ACSL6, G6PD, STAT1, CSF1
11	hormone activity	GO:005179	9.0	EPO, HAMP, NPPA, THPO, EDN1, IGF1
12	cytokine activity	GO:005125	8.3	TNFSF10, EDN1, THPO, CSF1, CSF2, CSF3
13	protein binding	GO:005515	4.9	EPOR, EIF5B, EIF4ENIF1, EIF2S1, ABL1, EGLN1