PV
MCID: PLY001
MIFTS: 82

Polycythemia Vera (PV) malady

Genetic diseases, Rare diseases, Cancer diseases, Blood diseases categories
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Summaries for Polycythemia Vera

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21Genetics Home Reference, 43NIH Rare Diseases, 65Wikipedia, 47OMIM, 33MalaCards
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Fully expand this MalaCard
Genetics Home Reference:21 Polycythemia vera is a condition characterized by an increased number of red blood cells in the bloodstream. Affected individuals may also have excess white blood cells and blood clotting cells called platelets. These extra cells cause the blood to be thicker than normal. As a result, abnormal blood clots are more likely to form and block the flow of blood through arteries and veins. Individuals with polycythemia vera have an increased risk of deep vein thrombosis (DVT), a type of blood clot that occurs in the deep veins of the arms or legs. If a DVT travels through the bloodstream and lodges in the lungs, it can cause a life-threatening clot known as a pulmonary embolism (PE). Affected individuals also have an increased risk of heart attack and stroke caused by blood clots in the heart and brain.

MalaCards: Polycythemia Vera, also known as PV, is related to polycythemia and myelofibrosis, and has symptoms including claudication/pain on mastication/while chewing, ecchymoses and tinnitus. An important gene associated with Polycythemia Vera is JAK2 (Janus kinase 2), and among its related pathways are Paxillin-dependent events mediated by a4b1 and Type II interferon signaling (IFNG). The drugs busulfan and hydroxyurea and the compounds pp 100 and filgrastim have been mentioned in the context of this disorder. Affiliated tissues include bone, myeloid and bone marrow, and related mouse phenotypes are adipose tissue and liver/biliary system.

NIH Rare Diseases:43 Polycythemia vera (pcv) is a condition characterized by an increased number of red blood cells in the bloodstream. affected people may also have excess white blood cells and platelets. these extra cells cause the blood to be thicker than normal, increasing the risk for blood clots that can block blood flow in arteries and veins. people with pcv have an increased risk of deep vein thrombosis which can cause a pulmonary embolism; heart attack; and stroke. most cases are not inherited and are acquired during a person's lifetime. in rare cases, the risk for pcv runs in families and may be inherited in an autosomal dominant manner. the condition has been associated with mutations in the jak2 and tet2 genes. last updated: 3/17/2014

Wikipedia:65 Polycythemia (or Polycythaemia, see spelling differences) vera (PV, PCV) (also known as erythremia,... more...

Description from OMIM:47 263300

Aliases & Classifications for Polycythemia Vera

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8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 40NCIt, 58SNOMED-CT, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

49
polycythemia vera:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

polycythemia vera 8 9 43 22 21 47 10 45 49 62
pv 43 21 49
polycythemia rubra vera 43 49
osler-vaquez disease 21 49
primary polycythemia 43 21
erythremia 8 49
prv 43 21
acquired primary erythocytosis 49
proliferative polycythaemia 8
polycythaemia rubra vera 8
polycythemia ruba vera 21
osler-vaquez syndrome 8
vaquez disease 49


External Ids:

Disease Ontology8 DOID:8997
NCIt40 C3336
OMIM47 263300
ICD9CM27 238.4
MeSH35 D011087
MESH via Orphanet36 D011087
ICD10 via Orphanet26 D45
SNOMED-CT via Orphanet59 109992005, 128841001
UMLS via Orphanet63 C0032463
ICD1025 D45

Related Diseases for Polycythemia Vera

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17GeneCards, 18GeneDecks
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Diseases related to Polycythemia Vera via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 213)
idRelated DiseaseScoreTop Affiliating Genes
1polycythemia32.1EPOR, EPO, JAK2, STAT5A, KITLG, CD177
2myelofibrosis31.6EPO, THPO, MPL, JAK2
3erythrocytosis31.0EPOR, JAK2, CD177, KITLG, MPL, EPO
4splenomegaly30.8JAK2, EPO, MPL, IFNA2, THPO
5primary polycythemia30.7JAK2, EPOR, STAT5A, EPO
6thrombocytosis30.7TET2, THPO, THBD, MPL, PF4, EPOR
7myeloid leukemia30.7KITLG, CSF3R, ACP1, STAT5A, THPO, PTPN6
8chronic lymphocytic leukemia30.6CSF3R, THPO, JAK2
9ischemia30.6SOCS3, EPOR, JAK2, PF4
10thrombocytopenia30.5IFNA2, KITLG, THPO, THBD, MPL, PF4
11erythromelalgia30.5THBD, PF4
12venous thrombosis30.5THBD, JAK2, PF4
13leukemia30.5CD177, HMGA2, KITLG, PDGFRB, CSF3R, ACP1
14purpura30.4THPO
15pancytopenia30.3EPO, MPL, THPO
16neurofibromatosis30.3EPOR, ACP1
17disseminated intravascular coagulation30.3THBD, THPO, PF4
18chronic myeloid leukemia30.2CD177, KITLG, PDGFRB, SOCS3, EPOR, EPO
19eosinophilia30.2PDGFRB, IFNA2, JAK2
20b-cell lymphomas30.2STAT5A, PTPN6, HMGA2, JAK2
21chronic myeloproliferative disease30.2JAK2, MPL, THPO, PDGFRB
22myeloproliferative disorder30.2THPO, THBD, CD177, KITLG, PDGFRB, CSF3R
23acute myocardial infarction30.2KITLG, THBD, PF4
24refractory anemia30.2KITLG, MPL, THPO, EPOR, EPO, JAK2
25vascular disease30.2PF4, JAK2, THBD
26malaria30.1ACP1
27atherosclerosis30.1PDGFRB, SOCS3, PF4, THBD, ACP1
28chronic myelomonocytic leukemia30.1JAK2, MPL, CSF3R, PDGFRB, KITLG, STAT5A
29sarcoma30.0PDGFRB, KITLG, THPO, JAK2, HMGA2, ACP1
30myeloma30.0TYK2, EPOR, PF4, EPO, JAK2, ACP1
31myelodysplastic syndromes29.9MPL, THPO, EPOR, EPO, JAK2, STAT5A
32essential thrombocythemia11.2
33endotheliitis10.6
34chronic neutrophilic leukemia10.5
35cerebritis10.4
36acute myeloid leukemia10.4
37focal segmental glomerulosclerosis10.4
38splenic infarction10.4
39hemochromatosis10.4
40glomerulosclerosis10.4
41hairy cell leukemia10.4
42hepatitis10.4
43heparin-induced thrombocytopenia10.4
44chorea10.4
45coronary thrombosis10.4
46osteonecrosis10.4
47glossitis10.4
48persistent vegetative state10.4
49gastrointestinal stromal tumor10.3
50porokeratosis10.3

Graphical network of the top 20 diseases related to Polycythemia Vera:



Diseases related to polycythemia vera

Symptoms for Polycythemia Vera

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47OMIM, 49Orphanet
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Symptoms by clinical synopsis from OMIM:

263300

Clinical features from OMIM:

263300

Symptoms:

49 (show all 25)
  • claudication/pain on mastication/while chewing
  • ecchymoses
  • tinnitus
  • arterial embolism/thrombosis
  • epistaxis/nose bleeding
  • acute leukemia
  • pruritus/itching
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • articular/joint pain/arthralgia
  • portal hypertension
  • asthenia/fatigue/weakness
  • splenomegaly
  • hepatomegaly/liver enlargement (excluding storage disease)
  • chronic arterial hypertension
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • acute abdominal pain/colic
  • dizziness
  • transient cerebral ischemia/stroke
  • facial pain/cephalalgia/migraine
  • myelodysplastic syndrome
  • venous thrombosis/phlebitis/thrombophlebitis
  • gingivorrhagia/gingival bleeding
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • angor pectoris/myocardial infarction
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction

Drugs & Therapeutics for Polycythemia Vera

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Polycythemia Vera

Search NIH Clinical Center for Polycythemia Vera

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Polycythemia Vera

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22GTR
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Genetic tests related to Polycythemia Vera:

id Genetic test Affiliating Genes
1 Polycythemia Vera22

Anatomical Context for Polycythemia Vera

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33MalaCards
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MalaCards organs/tissues related to Polycythemia Vera:

33
Bone, Myeloid, Bone marrow, Heart, Endothelial, Liver, Lung, Testes, B cells, T cells, Skin, Spinal cord, Prostate, Whole blood, Monocytes

Animal Models for Polycythemia Vera or affiliated genes

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37MGI
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Publications for Polycythemia Vera

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52PubMed
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Articles related to Polycythemia Vera:

(show top 50)    (show all 630)
idTitleAuthorsYear
1
Concomitant JAK2 V617F-positive polycythemia vera and B-cell chronic lymphocytic leukemia in three patients originating from two separate hematopoietic stem cells. (23280542)
2013
2
A phase 2 study of ruxolitinib, an oral JAK1 and JAK2 inhibitor, in patients with advanced polycythemia vera who are refractory or intolerant to hydroxyurea. (24258498)
2013
3
Macrophages support pathological erythropoiesis in polycythemia vera and I^-thalassemia. (23502961)
2013
4
Polycythemia vera: current pharmacotherapy and future directions. (23480062)
2013
5
Acute embolic cerebral ischemia as an initial presentation of polycythemia vera: a case report. (23683307)
2013
6
Treatment target in polycythemia vera. (23594012)
2013
7
Treatment target in polycythemia vera. (23594015)
2013
8
Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. (23152654)
2012
9
Detection of JAK2 mutations in paraffin marrow biopsies by high resolution melting analysis: identification of L611S alone and in cis with V617F in polycythemia vera. (22642932)
2012
10
Evaluation of hemostatic balance in blood from patients with polycythemia vera by means of thromboelastography: the effect of isovolemic erythrocytapheresis. (22098131)
2012
11
Severe chest and back pain and bilateral massive adrenal swelling in polycythemia vera: an uncommon case after esophagectomy. (22643542)
2012
12
Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: identification of deregulated genes of significance for inflammation and immune surveillance. (22877729)
2012
13
Treatment of polycythemia vera with imatinib mesylate. (21983176)
2012
14
Extent of hematopoietic involvement by TET2 mutations in JAK2Va8PA^a8^F polycythemia vera. (21273266)
2011
15
Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea. (21559940)
2011
16
JAK2 V617F and the evolving paradigm of polycythemia vera. (21120186)
2010
17
Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera. (20585043)
2010
18
Polycythemia vera as a presentation of renal angiomyolipoma: a case report. (19946506)
2009
19
The presence of JAK2V617F in primary myelofibrosis or its allele burden in polycythemia vera predicts chemosensitivity to hydroxyurea. (18266209)
2008
20
Sustained major molecular response on interferon alpha-2b in two patients with polycythemia vera. (18481066)
2008
21
Recurrent thrombosis in patients with polycythemia vera and essential thrombocythemia: incidence, risk factors, and effect of treatments. (18268279)
2008
22
Biomarker analysis in polycythemia vera under interferon-alpha treatment: clonality, EEC, PRV-1, and JAK2 V617F. (17256145)
2007
23
Identification of JAK2V617F in patients with polycythemia is highly correlated with conventional criteria for diagnosis of polycythemia vera. (16924638)
2007
24
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. (17267906)
2007
25
Polycythemia vera and JAK-2 mutation in childhood: a case report]. (17693067)
2007
26
A higher JAK2 V617F-mutated clone is observed in platelets than in granulocytes from essential thrombocythemia patients, but not in patients with polycythemia vera and primary myelofibrosis. (17361221)
2007
27
Anticoagulation after coronary artery surgery in patients with polycythemia vera: report of two cases. (17803581)
2007
28
Hematopoietic cell transplantation as curative therapy for idiopathic myelofibrosis, advanced polycythemia vera, and essential thrombocythemia. (17317589)
2007
29
Risk of thrombosis in patients with essential thrombocythemia and polycythemia vera according to JAK2 V617F mutation status. (17229651)
2007
30
Imatinib effect on growth and signal transduction in polycythemia vera. (17533047)
2007
31
Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis. (17976518)
2007
32
Elevated serum erythropoietin levels in patients with Budd-Chiari syndrome secondary to polycythemia vera: clinical implications for the role of JAK2 mutation analysis. (16827884)
2006
33
Minimal molecular response in polycythemia vera patients treated with imatinib or interferon alpha. (16352805)
2006
34
Polycythemia vera and its molecular basis: an update. (16781479)
2006
35
Arterial stenosis and atherothrombotic events in polycythemia vera and essential thrombocythemia. (18386616)
2006
36
The role of JAK2 V617F mutation, spontaneous erythropoiesis and megakaryocytopoiesis, hypersensitive platelets, activated leukocytes, and endothelial cells in the etiology of thrombotic manifestations in polycythemia vera and essential thrombocythemia. (16810614)
2006
37
Subarachnoid hemorrhage and diplopia as initial presentation of polycythemia vera. (15761220)
2005
38
Karyotype and molecular cytogenetic studies in polycythemia vera. (15865876)
2005
39
JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor. (16239216)
2005
40
Diagnostic approaches to polycythemia vera in 2004. (15225097)
2004
41
The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis. (13679323)
2003
42
Pseudohyperkalemia occurring in a patient with chronic renal failure and polycythemia vera without severe leukocytosis or thrombocytosis. (12508968)
2002
43
Posttranslational processing of the thrombopoietin receptor is impaired in polycythemia vera. (10515857)
1999
44
Historical perspective on the treatment of essential thrombocythemia and polycythemia vera. (9930553)
1999
45
Interleukin-10 inhibits erythropoietin-independent growth of erythroid bursts in patients with polycythemia vera. (9731054)
1998
46
Pathogenesis of polycythemia vera. (9549927)
1998
47
End-stage renal disease following polycythemia vera: in vitro and in vivo response of erythroid progenitors to erythropoietin and effects of sera on normal erythropoiesis. (9647492)
1998
48
Increased basal and induced tyrosine phosphorylation of the insulin-like growth factor I receptor beta subunit in circulating mononuclear cells of patients with polycythemia vera. (7542500)
1995
49
Megakaryoblastic transformation associated with disseminated intravascular coagulation in the course of polycythemia vera: a case report]. (1602615)
1992
50
Polycythemia vera terminating in chronic neutrophilic leukemia: report of a case. (2399908)
1990

Variations for Polycythemia Vera

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64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Polycythemia Vera:

64
id Symbol AA change Variation ID SNP ID
1JAK2p.Val617PheVAR_032697

Clinvar genetic disease variations for Polycythemia Vera:

1
id Gene Name Type Significance SNP ID Assembly Location
1JAK2NM_004972.3(JAK2): c.1849G> T (p.Val617Phe)single nucleotide variantPathogenic, risk factorrs77375493GRCh37Chr 9, 5073770: 5073770

Expression for genes affiliated with Polycythemia Vera

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polycythemia Vera

Search GEO for disease gene expression data for Polycythemia Vera.

Pathways for genes affiliated with Polycythemia Vera

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50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 54R&D Systems, 60Thomson Reuters, 30KEGG, 5Cell Signaling Technology
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Pathways related to Polycythemia Vera according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b738
a4b1 and a4b7 Integrin signaling38
9.8JAK2, EPO, EPOR
29.7IFNA2, JAK2, SOCS3
39.6IFNA2, JAK2, TYK2
49.6JAK2, SOCS3, TYK2
59.6JAK2, SOCS3, TYK2
6
Show member pathways
9.5SOCS3, JAK2, STAT5A
79.4STAT5A, JAK2, PTPN6
89.4PTPN6, JAK2, STAT5A
9
Show member pathways
IL27-mediated signaling events38
9.4STAT5A, JAK2, TYK2
10
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.4TYK2, JAK2, STAT5A
11
Show member pathways
9.4STAT5A, JAK2, TYK2
12
Show member pathways
9.2TYK2, PTPN6, SOCS3, IFNA2
13
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.2PDGFRB, JAK2, SOCS3, PTPN6
14
Show member pathways
Immune response IL 3 activation and signaling pathway60
9.2STAT5A, JAK2, SOCS3, PTPN6
159.2PTPN6, SOCS3, JAK2, STAT5A
169.2PTPN6, SOCS3, JAK2, STAT5A
179.2PTPN6, SOCS3, JAK2, STAT5A
18
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.1TYK2, SOCS3, JAK2, STAT5A
199.1TYK2, SOCS3, JAK2, STAT5A
209.1TYK2, SOCS3, JAK2, STAT5A
219.0THPO, EPOR, EPO, CSF3R, KITLG
22
Show member pathways
9.0PTPN6, EPOR, EPO, JAK2, STAT5A
238.9TYK2, PTPN6, SOCS3, STAT5A
24
Show member pathways
8.9CD177, PF4, PTPN6, THBD
25
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
8.8EPOR, EPO, JAK2, PDGFRB, KITLG
26
Show member pathways
8.8TYK2, SOCS3, JAK2, STAT5A, IFNA2
27
Show member pathways
8.7TYK2, PTPN6, SOCS3, JAK2, STAT5A
288.7TYK2, PTPN6, SOCS3, JAK2, STAT5A
298.7TYK2, PTPN6, SOCS3, JAK2, STAT5A
30
Show member pathways
EPO Receptor Signaling38
EPO signaling pathway38
8.7PTPN6, SOCS3, EPOR, EPO, JAK2, STAT5A
31
Show member pathways
8.6KITLG, PDGFRB, JAK2, TYK2, THPO
328.6TYK2, SOCS3, JAK2, PDGFRB, KITLG
338.6STAT5A, ACP1, PDGFRB
34
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.6THPO, TYK2, MPL, SOCS3, JAK2, STAT5A
35
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.5TYK2, SOCS3, JAK2, STAT5A, PDGFRB
368.5TYK2, SOCS3, JAK2, STAT5A, PDGFRB
37
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)38
8.5PTPN6, EPOR, EPO, JAK2, STAT5A, KITLG
38
Show member pathways
8.5TYK2, PTPN6, SOCS3, JAK2, STAT5A, IFNA2
39
Show member pathways
8.5KITLG, PDGFRB, STAT5A, JAK2, PTPN6
40
Show member pathways
8.3THPO, EPOR, JAK2, STAT5A, PDGFRB, KITLG
418.3EPOR, EPO, JAK2, IFNA2, CSF3R, PDGFRB
42
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
8.3STAT5A, JAK2, SOCS3, MPL, PTPN6, TYK2
43
Show member pathways
8.0THPO, THBD, PTPN6, MPL, PF4, JAK2
44
Show member pathways
7.8THPO, PTPN6, PF4, JAK2, CSF3R, PDGFRB
45
Show member pathways
7.6PTPN6, SOCS3, PF4, JAK2, STAT5A, PDGFRB
46
Show member pathways
Type III interferon signaling38
7.5EPO, EPOR, SOCS3, MPL, PTPN6, TYK2
47
Show member pathways
7.4THPO, PF4, EPOR, JAK2, STAT5A, CSF3R
48
Show member pathways
7.4THPO, PF4, EPOR, JAK2, STAT5A, CSF3R
49
Show member pathways
6.9THPO, TYK2, MPL, SOCS3, EPOR, EPO
50
Show member pathways
6.2KITLG, PDGFRB, CSF3R, IFNA2, STAT5A, JAK2

Compounds for genes affiliated with Polycythemia Vera

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45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Polycythemia Vera according to GeneCards/GeneDecks:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1pp 100459.9EPOR, JAK2, EPO
2filgrastim45 1110.4KITLG, CSF3R, IFNA2, EPO, THPO
3methylcellulose459.3CSF3R, EPO, KITLG, THPO, EPOR
4gm-csf45 2910.1THPO, EPO, STAT5A, KITLG
5anagrelide45 1110.1JAK2, EPO, PF4, MPL, IFNA2, THPO
65-aza-2deoxycytidine459.0THPO, PTPN6, EPO, JAK2, SOCS3, KITLG
7hydroxyurea45 51 1110.8KITLG, IFNA2, JAK2, PF4, EPO, THPO
8cytarabine45 51 1110.8KITLG, THPO, PTPN6, EPO, STAT5A, IFNA2
9polyethylene glycol458.7THPO, THBD, PF4, IFNA2, KITLG, MPL
10phenylalanine458.7CSF3R, STAT5A, JAK2, EPOR, PDGFRB, PTPN6
11aspirin45 51 29 2411.7MPL, PF4, THPO, THBD, JAK2, KITLG
12actinomycin d458.6THBD, JAK2, THPO, EPOR, KITLG, HMGA2
13sodium orthovanadate45 619.6JAK2, ACP1, TYK2, PTPN6, STAT5A
145fluorouracil458.4THPO, PF4, IFNA2, PDGFRB, MPL, KITLG
15imatinib45 51 1110.4KITLG, PDGFRB, CSF3R, STAT5A, JAK2, EPO
16lysine458.3IFNA2, PF4, JAK2, MPL, THPO, KITLG
17herbimycin a45 619.2PTPN6, KITLG, ACP1, JAK2, STAT5A
18epinephrine45 24 1110.1ACP1, THPO, PF4, KITLG, IFNA2, JAK2
19nitric oxide45 24 1110.1THPO, THBD, PTPN6, EPOR, JAK2, KITLG
20vanadate458.1PDGFRB, TYK2, PTPN6, JAK2, STAT5A, ACP1
21indomethacin45 29 61 1111.0PF4, THPO, STAT5A, JAK2, IFNA2, ACP1
22aspartate458.0ACP1, IFNA2, STAT5A, JAK2, EPO, PTPN6
23steroid457.9KITLG, THPO, THBD, EPOR, JAK2, IFNA2
24cyclosporin a45 29 619.9KITLG, ACP1, STAT5A, JAK2, EPO, THBD
25oligonucleotide457.8PTPN6, EPOR, JAK2, CSF3R, SOCS3, PDGFRB
26rapamycin457.8KITLG, ACP1, STAT5A, JAK2, EPO, THPO
27adp45 29 249.8THPO, THBD, TYK2, PTPN6, MPL, PF4
28cisplatin45 51 61 1110.8IFNA2, EPO, EPOR, JAK2, ACP1, HMGA2
29cycloheximide457.7ACP1, STAT5A, JAK2, SOCS3, THBD, KITLG
30agar457.6EPOR, MPL, THPO, JAK2, PDGFRB, PF4
31thymidine45 248.5JAK2, STAT5A, EPOR, CSF3R, KITLG, PF4
32genistein45 29 61 3 24 1112.5CSF3R, STAT5A, JAK2, ACP1, THPO, PDGFRB
33dexamethasone45 51 29 1110.4KITLG, STAT5A, THPO, THBD, ACP1, CSF3R
34h2o2457.4ACP1, JAK2, PTPN6, THBD, TYK2, THPO
35phosphotyrosine457.3EPOR, STAT5A, ACP1, CSF3R, PDGFRB, SOCS3
36ly294002457.2ACP1, EPO, TYK2, KITLG, PDGFRB, STAT5A
37lipid457.0JAK2, PF4, SOCS3, PTPN6, THBD, KITLG
38gp 130457.0PTPN6, KITLG, PDGFRB, TYK2, THPO, SOCS3
39wortmannin456.9JAK2, KITLG, THPO, PDGFRB, ACP1, STAT5A
40glucose456.8PDGFRB, IFNA2, THPO, THBD, KITLG, STAT5A
41estrogen456.6KITLG, PDGFRB, THPO, THBD, PTPN6, SOCS3
42cysteine456.6STAT5A, IFNA2, PDGFRB, ACP1, THBD, THPO
43oxygen45 247.5KITLG, PDGFRB, ACP1, IFNA2, STAT5A, JAK2
44calcium45 51 24 119.3EPOR, JAK2, STAT5A, CSF3R, PDGFRB, KITLG
45serine456.2MPL, SOCS3, CSF3R, EPOR, JAK2, STAT5A
46phosphatidylinositol456.1STAT5A, JAK2, EPO, EPOR, SOCS3, MPL
47retinoic acid45 247.1CSF3R, THPO, THBD, TYK2, IFNA2, PTPN6
48vegf455.6KITLG, THPO, THBD, PTPN6, MPL, PF4
49alanine455.4ACP1, IFNA2, STAT5A, JAK2, EPOR, PF4
50tyrosine454.7THPO, THBD, TYK2, IFNA2, STAT5A, JAK2

GO Terms for genes affiliated with Polycythemia Vera

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Sources:
16Gene Ontology
See all sources

Cellular components related to Polycythemia Vera according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4EPOR, EPO, IFNA2, CSF3R, KITLG, PF4
2extracellular spaceGO:0056158.0KITLG, IFNA2, EPO, PF4, THBD, THPO

Biological processes related to Polycythemia Vera according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.1EPO, JAK2
2mammary gland epithelium developmentGO:06118010.0STAT5A, JAK2
3regulation of interferon-gamma-mediated signaling pathwayGO:06033410.0PTPN6, SOCS3, JAK2
4positive regulation of phosphoprotein phosphatase activityGO:03251610.0PDGFRB, JAK2
5interferon-gamma-mediated signaling pathwayGO:0603339.9PTPN6, SOCS3, JAK2
6negative regulation of DNA bindingGO:0433929.9HMGA2, JAK2
7response to hyperoxiaGO:0550939.9PDGFRB, EPO
8myeloid cell differentiationGO:0300999.9TET2, THPO
9positive regulation of Ras protein signal transductionGO:0465799.9KITLG, EPO
10response to lipopolysaccharideGO:0324969.8THBD, EPO, JAK2
11negative regulation of mast cell apoptotic processGO:0330269.8KITLG, STAT5A
12positive regulation of mast cell proliferationGO:0706689.8KITLG, STAT5A
13JAK-STAT cascadeGO:0072599.8SOCS3, JAK2, STAT5A
14leukocyte migrationGO:0509009.7CD177, PTPN6, THBD
15positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.7PDGFRB, JAK2, PTPN6
16regulation of type I interferon-mediated signaling pathwayGO:0603389.6TYK2, PTPN6, SOCS3, IFNA2
17type I interferon signaling pathwayGO:0603379.5IFNA2, SOCS3, PTPN6, TYK2
18JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.5PTPN6, SOCS3, JAK2, STAT5A
19cell proliferationGO:0082839.4THPO, PTPN6, MPL, KITLG
20adrenal gland developmentGO:0303259.3HMGA2, PDGFRB
21positive regulation of cell proliferationGO:0082849.2PDGFRB, JAK2, EPO, PTPN6
22peptidyl-tyrosine phosphorylationGO:0181088.9TYK2, PTPN6, JAK2, STAT5A, PDGFRB
23cytokine-mediated signaling pathwayGO:0192218.7TYK2, PTPN6, SOCS3, PF4, JAK2, IFNA2
24signal transductionGO:0071658.5HMGA2, KITLG, PDGFRB, CSF3R, JAK2, EPO
25blood coagulationGO:0075968.4CD177, THPO, THBD, PTPN6, MPL, PF4

Molecular functions related to Polycythemia Vera according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1growth hormone receptor bindingGO:00513110.0JAK2, TYK2
2type 1 angiotensin receptor bindingGO:0317029.9TYK2, JAK2
3cytokine receptor activityGO:0048969.9MPL, CSF3R
4cytokine activityGO:0051259.5KITLG, IFNA2, THPO
5phosphatidylinositol 3-kinase bindingGO:0435489.5PDGFRB, JAK2
6protein tyrosine kinase activityGO:0047139.4PDGFRB, JAK2, TYK2
7protein bindingGO:0055155.1HMGA2, TET2, THBD, TYK2, PTPN6, SOCS3

Products for genes affiliated with Polycythemia Vera

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polycythemia Vera

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet