PV
MCID: PLY001
MIFTS: 83

Polycythemia Vera (PV) malady

Cancer diseases, Blood diseases categories

Summaries for Polycythemia Vera

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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Genetics Home Reference:21 Polycythemia vera is a condition characterized by an increased number of red blood cells in the bloodstream. Affected individuals may also have excess white blood cells and blood clotting cells called platelets. These extra cells cause the blood to be thicker than normal. As a result, abnormal blood clots are more likely to form and block the flow of blood through arteries and veins. Individuals with polycythemia vera have an increased risk of deep vein thrombosis (DVT), a type of blood clot that occurs in the deep veins of the arms or legs. If a DVT travels through the bloodstream and lodges in the lungs, it can cause a life-threatening clot known as a pulmonary embolism (PE). Affected individuals also have an increased risk of heart attack and stroke caused by blood clots in the heart and brain.

MalaCards: Polycythemia Vera, also known as PV, is related to polycythemia and myelofibrosis, and has symptoms including portal hypertension, myelodysplastic syndrome and claudication/pain on mastication/while chewing. An important gene associated with Polycythemia Vera is JAK2 (Janus kinase 2), and among its related pathways are Jak-STAT signaling pathway and Platelet activation, signaling and aggregation. The drugs busulfan and hydroxyurea and the compounds gp 130 and anagrelide have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and myeloid, and related mouse phenotypes are hematopoietic system and immune system.

NIH Rare Diseases:42 Polycythemia vera (pcv) is a condition characterized by an increased number of red blood cells in the bloodstream. affected people may also have excess white blood cells and platelets. these extra cells cause the blood to be thicker than normal, increasing the risk for blood clots that can block blood flow in arteries and veins. people with pcv have an increased risk of deep vein thrombosis which can cause a pulmonary embolism; heart attack; and stroke. most cases are not inherited and are acquired during a person's lifetime. in rare cases, the risk for pcv runs in families and may be inherited in an autosomal dominant manner. the condition has been associated with mutations in the jak2 and tet2 genes. last updated: 3/17/2014

Wikipedia:63 Polycythemia (or Polycythaemia, see spelling differences) vera (PV, PCV) (also known as erythremia,... more...

Description from OMIM:46 263300

Aliases & Classifications for Polycythemia Vera

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
polycythemia vera:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

polycythemia vera 8 9 42 22 21 46 10 44 48 60
pv 42 21 48
polycythemia rubra vera 42 48
osler-vaquez disease 21 48
primary polycythemia 42 21
erythremia 8 48
prv 42 21
acquired primary erythocytosis 48
proliferative polycythaemia 8
polycythaemia rubra vera 8
polycythemia ruba vera 21
osler-vaquez syndrome 8
vaquez disease 48


External Ids:

Disease Ontology8 DOID:8997
NCIt39 C3336
ICD9CM27 238.4
OMIM46 263300
MeSH34 D011087
MESH via Orphanet35 D011087
ICD10 via Orphanet26 D45
SNOMED-CT via Orphanet57 109992005, 128841001
UMLS via Orphanet61 C0032463
ICD1025 D45

Related Diseases for Polycythemia Vera

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17GeneCards, 18GeneDecks
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Diseases related to Polycythemia Vera via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1polycythemia32.2THPO, EPOR, EPO, CD177, MPL, STAT5A
2myelofibrosis31.5JAK2, MPL, EPO, THPO
3primary polycythemia31.3JAK2, STAT5A, EPO, EPOR
4leukemia31.2PTPN6, IFNA2, TET2, ACP1, THPO, HMGA2
5thrombocytosis30.9IFNA2, IFNA1, TET2, THPO, THBD, PF4
6myeloid leukemia30.8PTPN6, SOCS3, CSF3R, JAK2, JAK3, STAT5A
7acute leukemia30.7EPO, MPL, STAT5A, JAK2, CSF3R, EPOR
8chronic myeloid leukemia30.6PTPN6, THPO, EPOR, EPO, CD177, MPL
9thrombocytopenia30.6IFNA2, IFNA1, MPL, EPO, PF4, THBD
10acquired polycythemia30.5JAK2, EPO, EPOR
11ischemia30.5PF4, EPOR, JAK2, SOCS3
12hepatitis30.5THPO, IFNA1, IFNA2
13gastrointestinal stromal tumor30.4JAK3, PDGFRB
14glomerulonephritis30.3EPOR
15hemorrhagic thrombocythemia30.3CD177
16myocardial infarction30.3PF4
17thrombophilia30.3THBD, PF4
18erythromelalgia30.3THBD, PF4
19myeloma30.2EPOR, EPO, TYK2, STAT5A, JAK2, IFNA1
20deficiency anemia30.1IFNA2, IFNA1, CSF3R, JAK2, MPL, EPO
21chronic myeloproliferative disease30.1THPO, MPL, JAK2, PDGFRB
22sarcoma30.1PDGFRB, JAK2, HMGA2, THPO, ACP1
23portal vein thrombosis30.1THPO
24purpura30.1THPO
25disseminated intravascular coagulation30.1THPO, THBD, PF4
26vasculitis30.1IFNA2, THBD
27eosinophilia30.1IFNA2, PDGFRB, JAK2
28acute myocardial infarction30.1THBD, PF4
29tuberculosis30.1ACP1, PF4
30pancytopenia30.1MPL, EPO, THPO
31polyneuropathy30.1IFNA2
32atherosclerosis30.1ACP1, THBD, PF4, PDGFRB, SOCS3
33pulmonary embolism30.1PF4
34thyroiditis30.1IFNA1
35ovarian cancer29.9PDGFRB, JAK2, JAK3, ACP1, PTPN6
36neuroblastoma29.9CD177
37malaria29.9ACP1
38erythropoietin polycythemia10.7
39cerebritis10.4
40acute myeloid leukemia10.4
41splenic infarction10.4
42focal segmental glomerulosclerosis10.3
43hemochromatosis10.3
44focal glomerulosclerosis10.3
45chronic lymphocytic leukemia10.3
46hairy cell leukemia10.3
47osteonecrosis10.3
48coronary thrombosis10.3
49glossitis10.3
50axonal neuropathy10.3

Graphical network of the top 20 diseases related to Polycythemia Vera:



Diseases related to polycythemia vera

Clinical Features for Polycythemia Vera

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46OMIM, 48Orphanet
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Clinical features from OMIM:

263300

Clinical synopsis from OMIM:

263300

Symptoms:

48 (show all 25)
  • portal hypertension
  • myelodysplastic syndrome
  • claudication/pain on mastication/while chewing
  • ecchymoses
  • tinnitus
  • arterial embolism/thrombosis
  • epistaxis/nose bleeding
  • chronic arterial hypertension
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • asthenia/fatigue/weakness
  • articular/joint pain/arthralgia
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • pruritus/itching
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • acute abdominal pain/colic
  • angor pectoris/myocardial infarction
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • gingivorrhagia/gingival bleeding
  • venous thrombosis/phlebitis/thrombophlebitis
  • facial pain/cephalalgia/migraine
  • transient cerebral ischemia/stroke
  • dizziness
  • acute leukemia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction

Drugs & Therapeutics for Polycythemia Vera

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Polycythemia Vera

Drug clinical trials:

Search ClinicalTrials for Polycythemia Vera

Search NIH Clinical Center for Polycythemia Vera

Search CenterWatch for Polycythemia Vera

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Polycythemia Vera

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22GTR
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Genetic tests related to Polycythemia Vera:

id Genetic test Affiliating Genes
1 Polycythemia Vera22

Anatomical Context for Polycythemia Vera

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32MalaCards
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MalaCards organs/tissues related to Polycythemia Vera:

32
Heart, Bone, Myeloid, Bone marrow, Lung, Brain, Endothelial, Liver, Testes, B cells, T cells, Skin, Spinal cord, Prostate, Whole blood, Monocytes

Animal Models for Polycythemia Vera or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polycythemia Vera:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.7PTPN6, SOCS3, PDGFRB, CSF3R, JAK2, JAK3
2MP:000538710.7STAT5A, JAK3, JAK2, CSF3R, PDGFRB, SOCS3
3MP:000538410.7STAT5A, JAK3, JAK2, CSF3R, PDGFRB, SOCS3
4MP:000537610.7SOCS3, PDGFRB, JAK2, STAT5A, MPL, TYK2
5MP:001076810.6STAT5A, JAK3, JAK2, PDGFRB, SOCS3, MPL
6MP:001077110.5SOCS3, HMGA2
7MP:000287310.5SOCS3, PDGFRB, JAK2, STAT5A, EPO, EPOR
8MP:000538010.5THBD, EPOR, SOCS3
9MP:000537810.4SOCS3, PDGFRB, JAK2, STAT5A, MPL, HMGA2
10MP:000537010.2SOCS3, STAT5A, EPO, EPOR, THBD, TET2

Publications for Polycythemia Vera

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50PubMed
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Articles related to Polycythemia Vera:

(show top 50)    (show all 660)
idTitleAuthorsYear
1
Concomitant JAK2 V617F-positive polycythemia vera and B-cell chronic lymphocytic leukemia in three patients originating from two separate hematopoietic stem cells. (23280542)
2013
2
Treatment target in polycythemia vera. (23594012)
2013
3
Treatment target in polycythemia vera. (23594015)
2013
4
Leukocytosis in polycythemia vera and splenomegaly in essential thrombocythemia are independent risk factors for hemorrhage. (23281576)
2013
5
Proteomic analysis reveals heat shock protein 70 has a key role in polycythemia Vera. (24252366)
2013
6
Effects of imatinib mesylate in patients with polycythemia vera: results of a phase II study. (23525684)
2013
7
Intracardiac thrombosis in polycythemia vera. (23839603)
2013
8
JAK2V617F activates Lu/BCAM-mediated red cell adhesion in polycythemia vera through an EpoR-independent Rap1/Akt pathway. (23160466)
2013
9
Population pharmacokinetic analysis of orally-administered ruxolitinib (INCB018424 Phosphate) in patients with primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF) or post-essential thrombocythemia myelofibrosis (PET MF). (23677817)
2013
10
Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: identification of deregulated genes of significance for inflammation and immune surveillance. (22877729)
2012
11
Assessment and prognostic value of the European LeukemiaNet criteria for clinicohematologic response, resistance, and intolerance to hydroxyurea in polycythemia vera. (22160617)
2012
12
Right hepatic artery thrombosis in an essential polycythemia vera patient following pancreato-biliary surgery for severe pancreatitis. (22350625)
2012
13
Efficacy of vorinostat in a murine model of polycythemia vera. (22408262)
2012
14
Case of polycythemia vera concurrent with FIP1L1-PDGFRA-positive myeloproliferative neoplasm with eosinophilia. (22944561)
2012
15
The JAK2V617F allele burden and STAT3- and STAT5 phosphorylation in myeloproliferative neoplasms: early prefibrotic myelofibrosis compared with essential thrombocythemia, polycythemia vera and myelofibrosis. (21749449)
2011
16
Assessment of left ventricular myocardial performance by tissue Doppler echocardiography in patients with polycythemia vera. (21929589)
2011
17
Prognostic factors and models in polycythemia vera, essential thrombocythemia, and primary myelofibrosis. (22035744)
2011
18
Pruritic indurated plaques on the legs of a 62-year-old woman--quiz case. Polycythemia vera (PCV). (21242405)
2011
19
Type 1 diabetes caused by interferon alpha-2alpha in polycythemia vera therapy. (20980420)
2010
20
Transcriptional profiling of polycythemia vera identifies gene expression patterns both dependent and independent from the action of JAK2V617F. (20601445)
2010
21
A Case Report of Cerebral Venous Thrombosis in Polycythemia Vera Presenting with Intracranial and Spinal Subdural Hematoma. (20671855)
2010
22
Features of polycythemia vera in the 8p12 myeloproliferative syndrome. (20417870)
2010
23
Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis. (20008298)
2010
24
Polycythemia vera. (20237866)
2010
25
High percentage of JAK2 exon 12 mutation in Asian patients with polycythemia vera. (20660330)
2010
26
Treatment with the Bcl-xL inhibitor ABT-737 in combination with interferon I+ specifically targets JAK2V617F-positive polycythemia vera hematopoietic progenitor cells. (20625010)
2010
27
Src tyrosine kinase preactivation is associated with platelet hypersensitivity in essential thrombocythemia and polycythemia vera. (19965650)
2010
28
High transoxygenator pressure gradient in a patient with polycythemia vera. (19362496)
2010
29
The 'GGCC' haplotype of JAK2 confers susceptibility to JAK2 exon 12 mutation-positive polycythemia vera. (19440215)
2009
30
The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era. (19521323)
2009
31
Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients. (18541722)
2008
32
Aberrant expression of microRNA in polycythemia vera. (18508790)
2008
33
Clinical and molecular characterisation of a prospectively collected cohort of children and adolescents with polycythemia vera. (18557746)
2008
34
JAK2 617V>F positive polycythemia rubra vera maintained by approximately 18 stochastic stem-cell divisions per year, explaining age of onset by a single rate-limiting mutation. (17452518)
2007
35
Polycythemia vera and JAK-2 mutation in childhood: a case report]. (17693067)
2007
36
Different involvement of the megakaryocytic lineage by the JAK2 V617F mutation in Polycythemia vera, essential thrombocythemia and chronic idiopathic myelofibrosis. (17262192)
2007
37
Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera. (17105814)
2007
38
The role of JAK2 V617F mutation, spontaneous erythropoiesis and megakaryocytopoiesis, hypersensitive platelets, activated leukocytes, and endothelial cells in the etiology of thrombotic manifestations in polycythemia vera and essential thrombocythemia. (16810614)
2006
39
Karyotype and molecular cytogenetic studies in polycythemia vera. (15865876)
2005
40
Polycythemia vera and other primary polycythemias. (15725900)
2005
41
Endogenous erythroid and megakaryocytic circulating progenitors, HUMARA clonality assay, and PRV-1 expression are useful tools for diagnosis of polycythemia vera and essential thrombocythemia. (14998917)
2004
42
Diagnosis and treatment of polycythemia vera and possible future study designs of the PVSG. (10674896)
2000
43
Erythromelalgia: a clue to the diagnosis of polycythemia vera. (8864395)
1996
44
Recombinant interferon alpha-2b in the treatment of polycythemia vera. (8213763)
1993
45
Possible selective effects of interferon alpha-2b on a malignant clone in a case of polycythemia vera. (8471662)
1993
46
Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome, associated with preceding polycythemia vera. A case report and review of the literature. (3064544)
1988
47
Malignant histiocytosis occurring with acute myelogenous leukemia in a patient with longstanding polycythemia vera. (3466664)
1987
48
Polycythemia vera, primary hyperparathyroidism, and dysplastic nevus syndrome: report of a case. (3984947)
1985
49
Peripheral arterial occlusion and amaurosis fugax as the first manifestation of polycythemia vera. A case report. (6697006)
1984
50
Myelophthisic anemia as terminal stage of polycythemia vera; protracted x-ray treatment followed by a myelosclerotic syndrome. (14932790)
1952

Genetic Variations for Polycythemia Vera

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Polycythemia Vera:

62
id Symbol AA change Variation ID SNP ID
1JAK2p.Val617PheVAR_032697

Expression for genes affiliated with Polycythemia Vera

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polycythemia Vera

Search GEO for disease gene expression data for Polycythemia Vera.

Pathways for genes affiliated with Polycythemia Vera

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems
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Pathways related to Polycythemia Vera according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5JAK2, CSF3R, SOCS3, IFNA1, IFNA2, JAK3
2
Hide members
10.5IFNA2, IFNA1, JAK2, MPL, CD177, PF4
310.5EPOR, EPO, JAK2
4
Development EPO-induced Jak-STAT pathway
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10.5SOCS3, JAK2, STAT5A, EPO, EPOR, PTPN6
5
Development Thrombopoetin signaling via JAK-STAT pathway
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10.5PTPN6, THPO, TYK2, MPL, STAT5A, JAK3
6
Hide members
10.5JAK2, STAT5A, EPO, EPOR, PTPN6
710.5JAK2, STAT5A, EPO, EPOR, PTPN6
8
Hide members
10.5SOCS3, JAK2, JAK3, STAT5A, MPL, TYK2
910.5IFNA2, IFNA1, PDGFRB, CSF3R, JAK2, JAK3
1010.5CSF3R, EPO, EPOR, THPO
11
Hide members
10.5SOCS3, MPL, THPO
1210.5IFNA2, SOCS3, JAK2
1310.5PTPN6, JAK2, SOCS3
1410.5TYK2, JAK2, SOCS3
1510.5TYK2, JAK2, SOCS3
16
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10.5MPL, STAT5A, JAK3, JAK2, SOCS3
17
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10.5PDGFRB, CSF3R, JAK2, PF4, THPO, PTPN6
18
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10.5EPOR, TYK2, MPL, STAT5A, JAK3, JAK2
1910.5SOCS3, PDGFRB, JAK2, TYK2
20
Hide members
10.5PDGFRB, JAK2, JAK3, STAT5A, EPOR, THPO
21
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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10.5SOCS3, JAK2, JAK3, TYK2
2210.5IFNA2, IFNA1, JAK2, TYK2
2310.5PTPN6, STAT5A, JAK2, SOCS3
24
Hide members
10.5PTPN6, STAT5A, JAK2, SOCS3
2510.5PTPN6, STAT5A, JAK2
26
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10.5SOCS3, JAK2, JAK3, STAT5A, TYK2, PTPN6
2710.5SOCS3, JAK2, JAK3, STAT5A, TYK2, PTPN6
2810.5SOCS3, JAK2, JAK3, STAT5A, PTPN6
29
Immune response IL-2 activation and signaling pathway
Hide members
10.5SOCS3, JAK2, JAK3, STAT5A, PTPN6
30
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10.5IFNA2, IFNA1, SOCS3, JAK2, JAK3, STAT5A
31
Immune response Oncostatin M signaling via JAK-Stat in human cells
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10.5TYK2, STAT5A, JAK2, SOCS3
3210.5SOCS3, JAK2, STAT5A, TYK2
33
Hide members
10.5PDGFRB, CSF3R, JAK2, JAK3, STAT5A, EPOR
34
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10.5PDGFRB, CSF3R, JAK2, JAK3, STAT5A, EPOR
35
Hide members
10.5PDGFRB, JAK2, STAT5A, PTPN6
36
Immune response IFN alpha/beta signaling pathway
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10.5TYK2, IFNA2
37
Development PDGF signaling via STATs and NF-kB
Hide members
10.5SOCS3, PDGFRB, JAK2, STAT5A, TYK2
3810.5SOCS3, PDGFRB, JAK2, STAT5A, TYK2
39
Hide members
10.5JAK2, STAT5A, TYK2
4010.5SOCS3, JAK2, JAK3, STAT5A, TYK2
41
Hide members
10.5IFNA2, IFNA1, SOCS3, JAK2, JAK3, STAT5A
4210.5TYK2, SOCS3, IFNA1, IFNA2
43
Hide members
10.5IFNA2, IFNA1, SOCS3, PDGFRB, JAK2, JAK3
4410.5JAK2, JAK3, STAT5A, TYK2
45
Hide members
10.5JAK2, JAK3, STAT5A, TYK2
4610.5SOCS3, STAT5A, TYK2, PTPN6
4710.5SOCS3, STAT5A, TYK2
48
Hide members
10.5STAT5A, JAK3, SOCS3
4910.5PDGFRB, JAK3, STAT5A
5010.5ACP1, STAT5A, PDGFRB

Compounds for genes affiliated with Polycythemia Vera

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Polycythemia Vera according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1gp 1304411.0PTPN6, THPO, EPOR, EPO, SOCS3, PDGFRB
2anagrelide44 1112.0IFNA2, IFNA1, JAK2, MPL, EPO, PF4
3tyrosine4411.0PTPN6, PDGFRB, CSF3R, JAK2, JAK3, STAT5A
4phosphatidylinositol4410.9SOCS3, PDGFRB, CSF3R, JAK2, JAK3, STAT5A
5alanine4410.9IFNA2, IFNA1, PDGFRB, CSF3R, JAK2, STAT5A
6vegf4410.9IFNA2, IFNA1, PDGFRB, CSF3R, JAK2, JAK3
7thymidine44 2411.9JAK2, CSF3R, IFNA1, IFNA2, STAT5A, EPO
8serine4410.9SOCS3, CSF3R, JAK2, JAK3, MPL, EPOR
9agar4410.9PDGFRB, JAK2, STAT5A, MPL, EPOR, PF4
10phosphotyrosine4410.9SOCS3, PDGFRB, CSF3R, JAK2, JAK3, STAT5A
11ly2940024410.9PDGFRB, JAK2, JAK3, STAT5A, TYK2, EPO
12retinoic acid44 2411.9JAK2, CSF3R, PDGFRB, IFNA1, IFNA2, STAT5A
13cysteine4410.9STAT5A, JAK2, PDGFRB, IFNA2, MPL, EPOR
14wortmannin4410.9PDGFRB, JAK2, JAK3, STAT5A, TYK2, EPOR
15estrogen4410.9THPO, JAK3
16imatinib44 49 1112.9IFNA1, PDGFRB, CSF3R, JAK2, STAT5A, EPO
17hydroxyurea44 49 1112.9IFNA2, IFNA1, JAK2, EPO, PF4, THPO
18polyethylene glycol4410.9IFNA2, IFNA1, MPL, PF4, THBD, THPO
19vanadate4410.9PDGFRB, JAK2, STAT5A, TYK2, ACP1, PTPN6
20phenylalanine4410.9PDGFRB, CSF3R, JAK2, JAK3, STAT5A, EPOR
21genistein44 28 59 2 11 2415.9PDGFRB, CSF3R, JAK2, JAK3, STAT5A, THPO
22cytarabine44 49 1112.9IFNA2, IFNA1, STAT5A, EPO, THPO, PTPN6
23oligonucleotide4410.9SOCS3, PDGFRB, CSF3R, JAK2, STAT5A, EPOR
24oxygen44 2411.9CSF3R, JAK2, STAT5A, EPO, EPOR, PF4
25sodium orthovanadate44 5911.9JAK2, STAT5A, TYK2, ACP1, PTPN6
26cisplatin44 49 59 1113.9IFNA2, IFNA1, PDGFRB, JAK2, EPO, EPOR
27glucose4410.9IFNA2, SOCS3, PDGFRB, PF4, THBD, PTPN6
28filgrastim44 1111.8THPO, EPO, CSF3R, IFNA2
29aspartate4410.8JAK2, STAT5A, ACP1, PTPN6
30ifn-alpha4410.8IFNA2, IFNA1, SOCS3, STAT5A, TYK2
31rapamycin4410.8IFNA1, PDGFRB, JAK2, STAT5A, EPO, THPO
32adp44 28 2412.8JAK2, MPL, TYK2, PF4
335-aza-2deoxycytidine4410.8IFNA1, SOCS3, JAK2, EPO, THPO, PTPN6
34cycloheximide4410.8JAK3, IFNA1
35lipid4410.8IFNA2, SOCS3, PDGFRB, JAK2, JAK3, STAT5A
363-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile1110.8JAK2, JAK3, TYK2
375fluorouracil4410.8IFNA2, IFNA1, PDGFRB, MPL, PF4, THPO
38cyclosporin a44 28 5912.7IFNA1, JAK2, JAK3, STAT5A, EPO, THBD
39lysine4410.7IFNA2, SOCS3, CSF3R, JAK2, MPL, PF4
402-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE1110.7TYK2, JAK3, JAK2
41pp 1004410.7JAK2, EPO, EPOR
42etoposide44 49 59 1113.7IFNA2, IFNA1, STAT5A, PF4, THPO, ACP1
43nitric oxide44 11 2412.6SOCS3, JAK2, JAK3, STAT5A, EPOR, THBD
44indomethacin44 59 28 1113.6ACP1, PF4
45threonine4410.6SOCS3, PDGFRB, JAK2, JAK3, STAT5A, MPL
46mycophenolate mofetil44 49 1112.5IFNA1, JAK3, EPO, THBD
47methylcellulose4410.5THPO, EPOR, EPO, CSF3R
48ribavirin44 49 1112.5EPO, SOCS3, IFNA1, IFNA2
49herbimycin a44 5911.4JAK2, JAK3, STAT5A, ACP1, PTPN6
50h2o24410.2PDGFRB, JAK2, TYK2, THBD, THPO, ACP1

GO Terms for genes affiliated with Polycythemia Vera

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Sources:
16Gene Ontology
See all sources

Biological processes related to Polycythemia Vera according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759610.8IFNA2, JAK2, MPL, CD177, PF4, THBD
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.8PTPN6, STAT5A, JAK3, JAK2, SOCS3
3peptidyl-tyrosine phosphorylationGO:01810810.8PDGFRB, JAK2, JAK3, STAT5A, PTPN6
4regulation of type I interferon-mediated signaling pathwayGO:06033810.8IFNA2, SOCS3, TYK2, PTPN6
5cytokine-mediated signaling pathwayGO:01922110.8IFNA2, SOCS3, JAK2, TYK2, PF4, PTPN6
6type I interferon-mediated signaling pathwayGO:06033710.7IFNA2, SOCS3, TYK2, PTPN6
7regulation of interferon-gamma-mediated signaling pathwayGO:06033410.7PTPN6, JAK2, SOCS3
8intracellular protein kinase cascadeGO:00724310.7PDGFRB, JAK2, JAK3, TYK2
9JAK-STAT cascadeGO:00725910.7STAT5A, JAK2, SOCS3
10tyrosine phosphorylation of STAT proteinGO:00726010.7JAK3, JAK2
11positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.6PDGFRB, JAK2, PTPN6
12STAT protein import into nucleusGO:00726210.6JAK3, JAK2
13mammary gland epithelium developmentGO:06118010.5STAT5A, JAK2
14interferon-gamma-mediated signaling pathwayGO:06033310.5SOCS3, JAK2, PTPN6
15response to hyperoxiaGO:05509310.5EPO, PDGFRB
16positive regulation of phosphoprotein phosphatase activityGO:03251610.4JAK2, PDGFRB
17enzyme linked receptor protein signaling pathwayGO:00716710.2JAK3, JAK2

Molecular functions related to Polycythemia Vera according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.5PTPN6, IFNA2, SOCS3, PDGFRB, CSF3R, JAK2
2growth hormone receptor bindingGO:00513110.5TYK2, JAK2
3protein tyrosine kinase activityGO:00471310.4PDGFRB, JAK2, JAK3, TYK2
4non-membrane spanning protein tyrosine kinase activityGO:00471510.2TYK2, JAK3, JAK2

Products for genes affiliated with Polycythemia Vera

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polycythemia Vera

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet