PV
MCID: PLY001
MIFTS: 77

Polycythemia Vera (PV) malady

Cancer, Blood categories

Summaries for Polycythemia Vera

Sources:
21Genetics Home Reference, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Polycythemia vera is a condition characterized by an increased number of red blood cells within the bloodstream. affected individuals may also have excess white blood cells and platelets. these extra cells cause the blood to be thicker than normal. as a result, abnormal blood clots are more likely to form and block the flow of blood through arteries and veins. individuals with polycythemia vera have an increased risk of deep vein thrombosis (dvt), a type of blood clot that occurs in the deep veins of the arms or legs. if a dvt travels through the bloodstream and lodges in the lungs, it can cause a life-threatening clot known as a pulmonary embolism (pe). affected individuals also have an increased risk of heart attack and stroke caused by blood clots in the heart and brain. polycythemia vera is associated with mutations in the jak2 and tet2 genes. most cases are not inherited, as the condition is associated with genetic changes that are somatic, which means they are acquired during a person's lifetime and are present only in certain cells. last updated: 9/21/2010

MalaCards: Polycythemia Vera, also known as PV, is related to primary polycythemia and thrombocytosis, and has symptoms including respiratory distress/dyspnea/respiratory failure/lung volume reduction, chronic arterial hypertension and hepatomegaly/liver enlargement (excluding storage disease). An important gene associated with Polycythemia Vera is JAK2 (Janus kinase 2), and among its related pathways are Jak-STAT signaling pathway and Platelet activation, signaling and aggregation. The drugs busulfan and hydroxyurea and the compounds gp 130 and anagrelide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are hematopoietic system and immune system.

Genetics Home Reference:21 Polycythemia vera is a condition characterized by an increased number of red blood cells in the bloodstream. Affected individuals may also have excess white blood cells and blood clotting cells called platelets. These extra cells cause the blood to be thicker than normal. As a result, abnormal blood clots are more likely to form and block the flow of blood through arteries and veins. Individuals with polycythemia vera have an increased risk of deep vein thrombosis (DVT), a type of blood clot that occurs in the deep veins of the arms or legs. If a DVT travels through the bloodstream and lodges in the lungs, it can cause a life-threatening clot known as a pulmonary embolism (PE). Affected individuals also have an increased risk of heart attack and stroke caused by blood clots in the heart and brain.

Wikipedia:64 Polycythemia vera (PV, PCV) (also known as erythremia, primary polycythemia and polycythemia rubra vera)... more...

Description from OMIM:47 263300

Aliases & Classifications for Polycythemia Vera

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
polycythemia vera:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

polycythemia vera 8 9 43 22 21 47 10 45 49 61
pv 43 21 49
polycythemia rubra vera 43 49
osler-vaquez disease 21 49
erythremia 8 49
prv 43 21
acquired primary erythocytosis 49
proliferative polycythaemia 8
polycythaemia rubra vera 8
polycythemia ruba vera 21
osler-vaquez syndrome 8
primary polycythemia 21
vaquez disease 49


External Ids:

Disease Ontology8 DOID:8997
NCIt40 C3336
ICD9CM27 238.4
OMIM47 263300
MeSH35 D011087
MESH via Orphanet36 D011087
ICD10 via Orphanet26 D45
SNOMED-CT via Orphanet58 109992005, 128841001
UMLS via Orphanet62 C0032463
ICD1025 D45

Related Diseases for Polycythemia Vera

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Polycythemia Vera via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 228)
idRelated DiseaseScoreTop Affiliating Genes
1primary polycythemia31.3JAK2, STAT5A, EPO, EPOR
2thrombocytosis31.0IFNA2, IFNA1, TET2, THPO, THBD, PF4
3erythrocytosis30.9JAK2, MPL, CD177, EPO, EPOR
4myeloproliferative disorder30.7JAK2, CSF3R, PDGFRB, IFNA1, IFNA2, JAK3
5acute leukemia30.7EPO, MPL, STAT5A, JAK2, CSF3R, EPOR
6splenomegaly30.7THPO, EPO, MPL, JAK2, IFNA1, IFNA2
7chronic myeloid leukemia30.6PTPN6, THPO, EPOR, EPO, CD177, MPL
8thrombocytopenia30.6IFNA2, IFNA1, MPL, EPO, PF4, THBD
9acquired polycythemia30.5JAK2, EPO, EPOR
10gastrointestinal stromal tumor30.5JAK3, PDGFRB
11thromboembolism30.4THBD, PF4
12venous thrombosis30.4JAK2, PF4, THBD
13thalassemia30.4EPO
14thrombophilia30.4THBD, PF4
15erythromelalgia30.4THBD, PF4
16deficiency anemia30.2IFNA2, IFNA1, CSF3R, JAK2, MPL, EPO
17refractory anemia30.2JAK2, MPL, EPO, EPOR, THPO
18chronic myelomonocytic leukemia30.2PDGFRB, CSF3R, JAK2, STAT5A, MPL
19portal vein thrombosis30.2THPO
20vasculitis30.2IFNA2, THBD
21acute myocardial infarction30.2THBD, PF4
22tuberculosis30.2ACP1, PF4
23pancytopenia30.2MPL, EPO, THPO
24atherosclerosis30.2ACP1, THBD, PF4, PDGFRB, SOCS3
25hemorrhagic thrombocythemia30.2CD177
26essential thrombocythemia11.2
27erythropoietin polycythemia10.7
28chronic neutrophilic leukemia10.5
29acute myeloid leukemia10.4
30splenic infarction10.4
31thrombocythemia 210.4
32focal segmental glomerulosclerosis10.4
33hemochromatosis10.4
34focal glomerulosclerosis10.4
35n syndrome10.4
36t-cell leukemia10.4
37heparin-induced thrombocytopenia10.4
38chorea10.4
39osteonecrosis10.4
40coronary thrombosis10.4
41persistent vegetative state10.3
42axonal neuropathy10.3
43pernicious anemia10.3
44porokeratosis10.3
45chronic erythremia10.3
46antiphospholipid syndrome10.3
47ischemic neuropathy10.3
48hypercalcemia10.3
49capillary leak syndrome10.3
50megaloblastic anemia10.3

Graphical network of the top 20 diseases related to Polycythemia Vera:



Diseases related to polycythemia vera

Clinical Features for Polycythemia Vera

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

263300

Clinical synopsis from OMIM:

263300

Symptoms:

49 (show all 25)
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • chronic arterial hypertension
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • asthenia/fatigue/weakness
  • portal hypertension
  • articular/joint pain/arthralgia
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • pruritus/itching
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • acute abdominal pain/colic
  • angor pectoris/myocardial infarction
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • gingivorrhagia/gingival bleeding
  • venous thrombosis/phlebitis/thrombophlebitis
  • myelodysplastic syndrome
  • facial pain/cephalalgia/migraine
  • transient cerebral ischemia/stroke
  • dizziness
  • acute leukemia
  • epistaxis/nose bleeding
  • arterial embolism/thrombosis
  • tinnitus
  • ecchymoses
  • claudication/pain on mastication/while chewing

Drugs & Therapeutics for Polycythemia Vera

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Polycythemia Vera

Drug clinical trials:

Search ClinicalTrials for Polycythemia Vera

Search NIH Clinical Center for Polycythemia Vera

Search CenterWatch for Polycythemia Vera

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Polycythemia Vera

Sources:
22GTR
See all sources

Genetic tests related to Polycythemia Vera:

id Genetic test Affiliating Genes
1 Polycythemia Vera22

Anatomical Context for Polycythemia Vera

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Polycythemia Vera:

33
Skin, Liver, Spinal cord, Brain, Lung, Bone marrow, Whole blood, Heart, Small intestine, Prostate, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Polycythemia Vera or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Polycythemia Vera

Sources:
51PubMed
See all sources

Articles related to Polycythemia Vera:

(show top 50)    (show all 662)
idTitleAuthorsYear
1
A role of NF-E2 in chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis? (23932394)
2014
2
Sensomotor axonal peripheral neuropathy as a first complication of polycythemia rubra vera: A report of 3 cases. (24116263)
2013
3
MicroRNA expression and JAK2 allele burden in bone marrow trephine biopsies of polycythemia vera, essential thrombocythemia and early primary myelofibrosis. (23343777)
2013
4
The efficiency of therapeutic erythrocytapheresis compared to phlebotomy in relation to blood volume and delta-hematocrit: an evaluation in hereditary hemochromatosis polycythemia vera and secondary erythrocytosis. (23809828)
2013
5
Rethinking the diagnostic criteria of polycythemia vera. (24352199)
2013
6
Evaluation of the JAK2-V617F gene mutation in Turkish patients with essential thrombocythemia and polycythemia vera. (22722988)
2012
7
Critical requirement for Stat5 in a mouse model of polycythemia vera. (22144185)
2012
8
Polycythemia vera followed by hairy cell leukemia variant. (23387002)
2012
9
Extent of hematopoietic involvement by TET2 mutations in JAK2Va8PA^a8^F polycythemia vera. (21273266)
2011
10
Coexistence of I^-thalassemia and polycythemia vera. (21193338)
2011
11
JAK2V617F mutation and hydroxyurea treatment as determinants of immature platelet parameters in essential thrombocythemia and polycythemia vera patients. (21750318)
2011
12
Insights into the pathogenesis and management of thrombosis in polycythemia vera and essential thrombocythemia. (19789961)
2010
13
Imbalance of DNA-dependent protein kinase subunits in polycythemia vera peripheral blood stem cells. (19004005)
2009
14
Successful treatment with reduced-intensity stem cell transplantation for secondary myelofibrosis following polycythemia vera. (20009439)
2009
15
Recurrent thrombosis in patients with polycythemia vera and essential thrombocythemia: incidence, risk factors, and effect of treatments. (18268279)
2008
16
A dynamic prognostic model to predict survival in post-polycythemia vera myelofibrosis. (18187660)
2008
17
Polycythemia vera transforming to acute myeloid leukemia and complex abnormalities including 9p homogeneously staining region with amplification of MLLT3, JMJD2C, JAK2, and SMARCA2. (18068534)
2008
18
Risk factors of long-term incidences of thrombosis, myelofibrosis and evolution into malignance in polycythemia vera: a single center experience from China. (19002391)
2008
19
Thrombotic complications of polycythemia vera. (19055858)
2008
20
Perspective: Osler's 1903 paper on polycythemia vera. (18552569)
2008
21
Prospective identification of high-risk polycythemia vera patients based on JAK2(V617F) allele burden. (17625606)
2007
22
The JAK2 V617F allele burden in essential thrombocythemia, polycythemia vera and primary myelofibrosis--impact on disease phenotype. (17961178)
2007
23
Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. (17488875)
2007
24
Increased adhesion to endothelial cells of erythrocytes from patients with polycythemia vera is mediated by laminin alpha5 chain and Lu/BCAM. (17412890)
2007
25
Arterial stenosis and atherothrombotic events in polycythemia vera and essential thrombocythemia. (18386616)
2006
26
Long-term incidence of hematological evolution in three French prospective studies of hydroxyurea and pipobroman in polycythemia vera and essential thrombocythemia. (16810617)
2006
27
Limited effects on JAK2 mutational status after pegylated interferon alpha-2b therapy in polycythemia vera and essential thrombocythemia. (16956836)
2006
28
Overexpression of PRV-1 gene in polycythemia rubra vera and essential thrombocythemia. (16502591)
2006
29
Recovery of splenic infarction with anti-platelet treatments and platelet-apheresis in polycythemia vera. (16504586)
2006
30
Increased death receptor resistance and FLIPshort expression in polycythemia vera erythroid precursor cells. (16384930)
2006
31
Polycythemia vera: scientific advances and current practice. (16210034)
2005
32
Neuropharmacological therapy of polycythemia vera: roles of circulating catecholamines and serotonin. (15875317)
2005
33
Resolution of pruritus secondary to polycythemia vera in a patient treated with narrow-band ultraviolet B phototherapy. (15897170)
2005
34
Bone marrow histopathology and biological markers as specific clues to the differential diagnosis of essential thrombocythemia, polycythemia vera and prefibrotic or fibrotic agnogenic myeloid metaplasia. (15048058)
2004
35
Usefulness of the quantitative assessment of PRV-1 gene expression for the diagnosis of polycythemia vera and essential thrombocythemia patients. (14998918)
2004
36
Budd-Chiari syndrome with fatal outcome in a patient with polycythemia vera and antiphospholipid antibody syndrome]. (15529946)
2004
37
The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis. (13679323)
2003
38
Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera. (12239154)
2002
39
Comparative genomic hybridization in polycythemia vera and essential thrombocytosis patients. (11463455)
2001
40
Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. (10753836)
2000
41
Transition of polycythemia vera to chronic neutrophilic leukemia. (10194140)
1999
42
Polycythemia vera treated with recombinant interferon-alpha 2a: evidence of a selective effect on the malignant clone. (9326356)
1997
43
Polycythemia vera. V. Enhanced proliferation and phosphorylation due to vanadate are diminished in polycythemia vera erythroid progenitor cells: a possible defect of phosphatase activity in polycythemia vera. (9160662)
1997
44
Increased basal and induced tyrosine phosphorylation of the insulin-like growth factor I receptor beta subunit in circulating mononuclear cells of patients with polycythemia vera. (7542500)
1995
45
High plasma levels of plasminogen activator inhibitor 1 (PAI-1) in polycythemia vera and essential thrombocythemia are associated with thrombosis. (7992252)
1994
46
Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin-like growth factor-1 in vitro: studies in an improved serum-free medium. (8274756)
1994
47
Recombinant alpha 2a interferon and polycythemia vera: clinical results and biological evaluation by means of Fourier-transform infrared microspectroscopy. (7957805)
1994
48
Correction of anemia by recombinant human erythropoietin in a patient with polycythemia vera associated with hemodialysis-dependent chronic renal failure. (2069164)
1991
49
Polycythemia rubra vera with pernicious anemia. Some observations on vitamin B 12 metabolism. (4892033)
1969
50
Hepatic vein thrombosis complicating polycythemia vera. Successful treatment with a portacaval shunt. (6028691)
1967

Genetic Variations for Polycythemia Vera

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Polycythemia Vera:

63
id Symbol AA change Variation SNP ID
1JAK2p.Val617PheVAR_032697

Expression for genes affiliated with Polycythemia Vera

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Polycythemia Vera

Search GEO for disease gene expression data for Polycythemia Vera.

Pathways for genes affiliated with Polycythemia Vera

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 52QIAGEN, 53R&D Systems
See all sources

Pathways related to Polycythemia Vera according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5JAK2, CSF3R, SOCS3, IFNA1, IFNA2, JAK3
2
Hide members
10.5IFNA2, IFNA1, JAK2, MPL, CD177, PF4
310.5EPOR, EPO, JAK2
4
Development EPO-induced Jak-STAT pathway
Hide members
10.5SOCS3, JAK2, STAT5A, EPO, EPOR, PTPN6
5
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
10.5PTPN6, THPO, TYK2, MPL, STAT5A, JAK3
6
Hide members
10.5JAK2, STAT5A, EPO, EPOR, PTPN6
710.5JAK2, STAT5A, EPO, EPOR, PTPN6
8
Hide members
10.5SOCS3, JAK2, JAK3, STAT5A, MPL, TYK2
910.5IFNA2, IFNA1, PDGFRB, CSF3R, JAK2, JAK3
1010.5CSF3R, EPO, EPOR, THPO
11
Hide members
10.5SOCS3, MPL, THPO
1210.5IFNA2, SOCS3, JAK2
1310.5PTPN6, JAK2, SOCS3
1410.5TYK2, JAK2, SOCS3
1510.5TYK2, JAK2, SOCS3
16
Hide members
10.5MPL, STAT5A, JAK3, JAK2, SOCS3
17
Hide members
10.5PDGFRB, CSF3R, JAK2, PF4, THPO, PTPN6
18
Hide members
10.5EPOR, TYK2, MPL, STAT5A, JAK3, JAK2
1910.5SOCS3, PDGFRB, JAK2, TYK2
20
Hide members
10.5PDGFRB, JAK2, JAK3, STAT5A, EPOR, THPO
21
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.5SOCS3, JAK2, JAK3, TYK2
2210.5IFNA2, IFNA1, JAK2, TYK2
2310.5PTPN6, STAT5A, JAK2, SOCS3
24
Hide members
10.5PTPN6, STAT5A, JAK2, SOCS3
2510.5PTPN6, STAT5A, JAK2
26
Hide members
10.5SOCS3, JAK2, JAK3, STAT5A, TYK2, PTPN6
2710.5SOCS3, JAK2, JAK3, STAT5A, TYK2, PTPN6
2810.5SOCS3, JAK2, JAK3, STAT5A, PTPN6
29
Immune response IL-2 activation and signaling pathway
Hide members
10.5SOCS3, JAK2, JAK3, STAT5A, PTPN6
30
Hide members
10.5IFNA2, IFNA1, SOCS3, JAK2, JAK3, STAT5A
31
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
10.5TYK2, STAT5A, JAK2, SOCS3
3210.5SOCS3, JAK2, STAT5A, TYK2
33
Hide members
10.5PDGFRB, CSF3R, JAK2, JAK3, STAT5A, EPOR
34
Hide members
10.5PDGFRB, CSF3R, JAK2, JAK3, STAT5A, EPOR
35
Hide members
10.5PDGFRB, JAK2, STAT5A, PTPN6
36
Immune response IFN alpha/beta signaling pathway
Hide members
10.5TYK2, IFNA2
37
Development PDGF signaling via STATs and NF-kB
Hide members
10.5SOCS3, PDGFRB, JAK2, STAT5A, TYK2
3810.5SOCS3, PDGFRB, JAK2, STAT5A, TYK2
39
Hide members
10.5JAK2, STAT5A, TYK2
4010.5SOCS3, JAK2, JAK3, STAT5A, TYK2
41
Hide members
10.5IFNA2, IFNA1, SOCS3, JAK2, JAK3, STAT5A
4210.5TYK2, SOCS3, IFNA1, IFNA2
43
Hide members
10.5IFNA2, IFNA1, SOCS3, PDGFRB, JAK2, JAK3
4410.5JAK2, JAK3, STAT5A, TYK2
45
Hide members
10.5JAK2, JAK3, STAT5A, TYK2
4610.5SOCS3, STAT5A, TYK2, PTPN6
4710.5SOCS3, STAT5A, TYK2
48
Hide members
10.5STAT5A, JAK3, SOCS3
4910.5PDGFRB, JAK3, STAT5A
5010.5ACP1, STAT5A, PDGFRB

Compounds for genes affiliated with Polycythemia Vera

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Polycythemia Vera according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1gp 1304511.0PTPN6, THPO, EPOR, EPO, SOCS3, PDGFRB
2anagrelide45 1112.0IFNA2, IFNA1, JAK2, MPL, EPO, PF4
3tyrosine4511.0PTPN6, PDGFRB, CSF3R, JAK2, JAK3, STAT5A
4phosphatidylinositol4510.9SOCS3, PDGFRB, CSF3R, JAK2, JAK3, STAT5A
5alanine4510.9IFNA2, IFNA1, PDGFRB, CSF3R, JAK2, STAT5A
6vegf4510.9IFNA2, IFNA1, PDGFRB, CSF3R, JAK2, JAK3
7thymidine45 2411.9JAK2, CSF3R, IFNA1, IFNA2, STAT5A, EPO
8serine4510.9SOCS3, CSF3R, JAK2, JAK3, MPL, EPOR
9agar4510.9PDGFRB, JAK2, STAT5A, MPL, EPOR, PF4
10phosphotyrosine4510.9SOCS3, PDGFRB, CSF3R, JAK2, JAK3, STAT5A
11ly2940024510.9PDGFRB, JAK2, JAK3, STAT5A, TYK2, EPO
12retinoic acid45 2411.9JAK2, CSF3R, PDGFRB, IFNA1, IFNA2, STAT5A
13cysteine4510.9STAT5A, JAK2, PDGFRB, IFNA2, MPL, EPOR
14wortmannin4510.9PDGFRB, JAK2, JAK3, STAT5A, TYK2, EPOR
15estrogen4510.9THPO, JAK3
16imatinib45 50 1112.9IFNA1, PDGFRB, CSF3R, JAK2, STAT5A, EPO
17hydroxyurea45 50 1112.9IFNA2, IFNA1, JAK2, EPO, PF4, THPO
18polyethylene glycol4510.9IFNA2, IFNA1, MPL, PF4, THBD, THPO
19vanadate4510.9PDGFRB, JAK2, STAT5A, TYK2, ACP1, PTPN6
20phenylalanine4510.9PDGFRB, CSF3R, JAK2, JAK3, STAT5A, EPOR
21genistein45 29 60 2 11 2415.9PDGFRB, CSF3R, JAK2, JAK3, STAT5A, THPO
22cytarabine45 50 1112.9IFNA2, IFNA1, STAT5A, EPO, THPO, PTPN6
23oligonucleotide4510.9SOCS3, PDGFRB, CSF3R, JAK2, STAT5A, EPOR
24oxygen45 2411.9CSF3R, JAK2, STAT5A, EPO, EPOR, PF4
25sodium orthovanadate45 6011.9JAK2, STAT5A, TYK2, ACP1, PTPN6
26cisplatin45 50 60 1113.9IFNA2, IFNA1, PDGFRB, JAK2, EPO, EPOR
27glucose4510.9IFNA2, SOCS3, PDGFRB, PF4, THBD, PTPN6
28filgrastim45 1111.8THPO, EPO, CSF3R, IFNA2
29aspartate4510.8JAK2, STAT5A, ACP1, PTPN6
30ifn-alpha4510.8IFNA2, IFNA1, SOCS3, STAT5A, TYK2
31rapamycin4510.8IFNA1, PDGFRB, JAK2, STAT5A, EPO, THPO
32adp45 29 2412.8JAK2, MPL, TYK2, PF4
335-aza-2deoxycytidine4510.8IFNA1, SOCS3, JAK2, EPO, THPO, PTPN6
34cycloheximide4510.8JAK3, IFNA1
35lipid4510.8IFNA2, SOCS3, PDGFRB, JAK2, JAK3, STAT5A
363-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile1110.8JAK2, JAK3, TYK2
375fluorouracil4510.8IFNA2, IFNA1, PDGFRB, MPL, PF4, THPO
38cyclosporin a45 29 6012.7IFNA1, JAK2, JAK3, STAT5A, EPO, THBD
39lysine4510.7IFNA2, SOCS3, CSF3R, JAK2, MPL, PF4
402-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE1110.7TYK2, JAK3, JAK2
41pp 1004510.7JAK2, EPO, EPOR
42etoposide45 50 60 1113.7IFNA2, IFNA1, STAT5A, PF4, THPO, ACP1
43nitric oxide45 11 2412.6SOCS3, JAK2, JAK3, STAT5A, EPOR, THBD
44indomethacin45 60 29 1113.6ACP1, PF4
45threonine4510.6SOCS3, PDGFRB, JAK2, JAK3, STAT5A, MPL
46mycophenolate mofetil45 50 1112.5IFNA1, JAK3, EPO, THBD
47methylcellulose4510.5THPO, EPOR, EPO, CSF3R
48ribavirin45 50 1112.5EPO, SOCS3, IFNA1, IFNA2
49herbimycin a45 6011.4JAK2, JAK3, STAT5A, ACP1, PTPN6
50h2o24510.2PDGFRB, JAK2, TYK2, THBD, THPO, ACP1

GO Terms for genes affiliated with Polycythemia Vera

Sources:
16Gene Ontology
See all sources

Biological processes related to Polycythemia Vera according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759610.8IFNA2, JAK2, MPL, CD177, PF4, THBD
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.8PTPN6, STAT5A, JAK3, JAK2, SOCS3
3peptidyl-tyrosine phosphorylationGO:01810810.8PDGFRB, JAK2, JAK3, STAT5A, PTPN6
4regulation of type I interferon-mediated signaling pathwayGO:06033810.8IFNA2, SOCS3, TYK2, PTPN6
5cytokine-mediated signaling pathwayGO:01922110.8IFNA2, SOCS3, JAK2, TYK2, PF4, PTPN6
6type I interferon-mediated signaling pathwayGO:06033710.7IFNA2, SOCS3, TYK2, PTPN6
7regulation of interferon-gamma-mediated signaling pathwayGO:06033410.7PTPN6, JAK2, SOCS3
8intracellular protein kinase cascadeGO:00724310.7PDGFRB, JAK2, JAK3, TYK2
9JAK-STAT cascadeGO:00725910.7STAT5A, JAK2, SOCS3
10tyrosine phosphorylation of STAT proteinGO:00726010.7JAK3, JAK2
11positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.6PDGFRB, JAK2, PTPN6
12STAT protein import into nucleusGO:00726210.6JAK3, JAK2
13mammary gland epithelium developmentGO:06118010.5STAT5A, JAK2
14interferon-gamma-mediated signaling pathwayGO:06033310.5SOCS3, JAK2, PTPN6
15response to hyperoxiaGO:05509310.5EPO, PDGFRB
16positive regulation of phosphoprotein phosphatase activityGO:03251610.4JAK2, PDGFRB
17enzyme linked receptor protein signaling pathwayGO:00716710.2JAK3, JAK2

Molecular functions related to Polycythemia Vera according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.5PTPN6, IFNA2, SOCS3, PDGFRB, CSF3R, JAK2
2growth hormone receptor bindingGO:00513110.5TYK2, JAK2
3protein tyrosine kinase activityGO:00471310.4PDGFRB, JAK2, JAK3, TYK2
4non-membrane spanning protein tyrosine kinase activityGO:00471510.2TYK2, JAK3, JAK2

Products for genes affiliated with Polycythemia Vera

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polycythemia Vera

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet