PV
MCID: PLY001
MIFTS: 83

Polycythemia Vera (PV) malady

Cancer diseases, Blood diseases categories

Summaries for Polycythemia Vera

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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Genetics Home Reference:21 Polycythemia vera is a condition characterized by an increased number of red blood cells in the bloodstream. Affected individuals may also have excess white blood cells and blood clotting cells called platelets. These extra cells cause the blood to be thicker than normal. As a result, abnormal blood clots are more likely to form and block the flow of blood through arteries and veins. Individuals with polycythemia vera have an increased risk of deep vein thrombosis (DVT), a type of blood clot that occurs in the deep veins of the arms or legs. If a DVT travels through the bloodstream and lodges in the lungs, it can cause a life-threatening clot known as a pulmonary embolism (PE). Affected individuals also have an increased risk of heart attack and stroke caused by blood clots in the heart and brain.

MalaCards: Polycythemia Vera, also known as PV, is related to polycythemia and myelofibrosis, and has symptoms including gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia, weight loss/loss of appetite/break in weight curve/general health alteration and transient cerebral ischemia/stroke. An important gene associated with Polycythemia Vera is JAK2 (Janus kinase 2), and among its related pathways are Jak-STAT signaling pathway and Platelet activation, signaling and aggregation. The drugs busulfan and hydroxyurea and the compounds tyrosine and gp 130 have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and myeloid, and related mouse phenotypes are hematopoietic system and immune system.

NIH Rare Diseases:42 Polycythemia vera (pcv) is a condition characterized by an increased number of red blood cells in the bloodstream. affected people may also have excess white blood cells and platelets. these extra cells cause the blood to be thicker than normal, increasing the risk for blood clots that can block blood flow in arteries and veins. people with pcv have an increased risk of deep vein thrombosis which can cause a pulmonary embolism; heart attack; and stroke. most cases are not inherited and are acquired during a person's lifetime. in rare cases, the risk for pcv runs in families and may be inherited in an autosomal dominant manner. the condition has been associated with mutations in the jak2 and tet2 genes. last updated: 3/17/2014

Wikipedia:63 Polycythemia (or Polycythaemia, see spelling differences) vera (PV, PCV) (also known as erythremia,... more...

Description from OMIM:46 263300

Aliases & Classifications for Polycythemia Vera

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
polycythemia vera:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

polycythemia vera 8 9 42 22 21 46 10 44 48 60
pv 42 21 48
polycythemia rubra vera 42 48
primary polycythemia 42 21
osler-vaquez disease 21 48
erythremia 8 48
prv 42 21
acquired primary erythocytosis 48
proliferative polycythaemia 8
polycythaemia rubra vera 8
polycythemia ruba vera 21
osler-vaquez syndrome 8
vaquez disease 48


External Ids:

Disease Ontology8 DOID:8997
NCIt39 C3336
ICD9CM27 238.4
OMIM46 263300
MeSH34 D011087
MESH via Orphanet35 D011087
ICD10 via Orphanet26 D45
SNOMED-CT via Orphanet57 109992005, 128841001
UMLS via Orphanet61 C0032463
ICD1025 D45

Related Diseases for Polycythemia Vera

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17GeneCards, 18GeneDecks
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Diseases related to Polycythemia Vera via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1polycythemia32.2THPO, EPOR, EPO, CD177, MPL, STAT5A
2myelofibrosis31.5JAK2, MPL, EPO, THPO
3primary polycythemia31.3JAK2, STAT5A, EPO, EPOR
4leukemia31.2PTPN6, IFNA2, TET2, ACP1, THPO, HMGA2
5thrombocytosis30.9IFNA2, IFNA1, TET2, THPO, THBD, PF4
6myeloid leukemia30.8PTPN6, SOCS3, CSF3R, JAK2, JAK3, STAT5A
7acute leukemia30.7EPO, MPL, STAT5A, JAK2, CSF3R, EPOR
8chronic myeloid leukemia30.6PTPN6, THPO, EPOR, EPO, CD177, MPL
9thrombocytopenia30.6IFNA2, IFNA1, MPL, EPO, PF4, THBD
10acquired polycythemia30.5JAK2, EPO, EPOR
11ischemia30.5PF4, EPOR, JAK2, SOCS3
12hepatitis30.5THPO, IFNA1, IFNA2
13gastrointestinal stromal tumor30.4JAK3, PDGFRB
14glomerulonephritis30.3EPOR
15hemorrhagic thrombocythemia30.3CD177
16myocardial infarction30.3PF4
17thrombophilia30.3THBD, PF4
18erythromelalgia30.3THBD, PF4
19myeloma30.2EPOR, EPO, TYK2, STAT5A, JAK2, IFNA1
20deficiency anemia30.1IFNA2, IFNA1, CSF3R, JAK2, MPL, EPO
21chronic myeloproliferative disease30.1THPO, MPL, JAK2, PDGFRB
22sarcoma30.1PDGFRB, JAK2, HMGA2, THPO, ACP1
23portal vein thrombosis30.1THPO
24purpura30.1THPO
25disseminated intravascular coagulation30.1THPO, THBD, PF4
26vasculitis30.1IFNA2, THBD
27eosinophilia30.1IFNA2, PDGFRB, JAK2
28acute myocardial infarction30.1THBD, PF4
29tuberculosis30.1ACP1, PF4
30pancytopenia30.1MPL, EPO, THPO
31polyneuropathy30.1IFNA2
32atherosclerosis30.1ACP1, THBD, PF4, PDGFRB, SOCS3
33pulmonary embolism30.1PF4
34thyroiditis30.1IFNA1
35ovarian cancer29.9PDGFRB, JAK2, JAK3, ACP1, PTPN6
36neuroblastoma29.9CD177
37malaria29.9ACP1
38erythropoietin polycythemia10.7
39cerebritis10.4
40acute myeloid leukemia10.4
41splenic infarction10.4
42focal segmental glomerulosclerosis10.3
43hemochromatosis10.3
44focal glomerulosclerosis10.3
45chronic lymphocytic leukemia10.3
46hairy cell leukemia10.3
47osteonecrosis10.3
48coronary thrombosis10.3
49glossitis10.3
50axonal neuropathy10.3

Graphical network of the top 20 diseases related to Polycythemia Vera:



Diseases related to polycythemia vera

Clinical Features for Polycythemia Vera

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46OMIM, 48Orphanet
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Clinical features from OMIM:

263300

Clinical synopsis from OMIM:

263300

Symptoms:

48 (show all 25)
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • transient cerebral ischemia/stroke
  • venous thrombosis/phlebitis/thrombophlebitis
  • arterial embolism/thrombosis
  • portal hypertension
  • pruritus/itching
  • dizziness
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • ecchymoses
  • acute abdominal pain/colic
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • angor pectoris/myocardial infarction
  • chronic arterial hypertension
  • facial pain/cephalalgia/migraine
  • epistaxis/nose bleeding
  • gingivorrhagia/gingival bleeding
  • acute leukemia
  • myelodysplastic syndrome
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • articular/joint pain/arthralgia
  • asthenia/fatigue/weakness
  • claudication/pain on mastication/while chewing
  • tinnitus

Drugs & Therapeutics for Polycythemia Vera

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Polycythemia Vera

Drug clinical trials:

Search ClinicalTrials for Polycythemia Vera

Search NIH Clinical Center for Polycythemia Vera

Search CenterWatch for Polycythemia Vera

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Polycythemia Vera

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22GTR
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Genetic tests related to Polycythemia Vera:

id Genetic test Affiliating Genes
1 Polycythemia Vera22

Anatomical Context for Polycythemia Vera

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32MalaCards
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MalaCards organs/tissues related to Polycythemia Vera:

32
Heart, Bone, Myeloid, Bone marrow, Lung, Brain, Endothelial, Liver, Testes, B cells, T cells, Skin, Whole blood, Monocytes, Spinal cord, Prostate

Animal Models for Polycythemia Vera or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polycythemia Vera:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.7PTPN6, SOCS3, PDGFRB, CSF3R, JAK2, JAK3
2MP:000538710.7STAT5A, JAK3, JAK2, CSF3R, PDGFRB, SOCS3
3MP:000538410.7STAT5A, JAK3, JAK2, CSF3R, PDGFRB, SOCS3
4MP:000537610.7SOCS3, PDGFRB, JAK2, STAT5A, MPL, TYK2
5MP:001076810.6STAT5A, JAK3, JAK2, PDGFRB, SOCS3, MPL
6MP:001077110.5SOCS3, HMGA2
7MP:000287310.5SOCS3, PDGFRB, JAK2, STAT5A, EPO, EPOR
8MP:000538010.5THBD, EPOR, SOCS3
9MP:000537810.4SOCS3, PDGFRB, JAK2, STAT5A, MPL, HMGA2
10MP:000537010.2SOCS3, STAT5A, EPO, EPOR, THBD, TET2

Publications for Polycythemia Vera

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50PubMed
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Articles related to Polycythemia Vera:

(show top 50)    (show all 660)
idTitleAuthorsYear
1
Acute embolic cerebral ischemia as an initial presentation of polycythemia vera: a case report. (23683307)
2013
2
Myeloid sarcoma developing in prexisting hydroxyurea-induced leg ulcer in a polycythemia vera patient. (24109489)
2013
3
Development of JAK2V617F-positive polycythemia vera after chemotherapy-induced remission of primary central nervous system diffuse large B cell non-Hodgkin's lymphoma: a case report and review of the literature. (23652352)
2013
4
The efficiency of therapeutic erythrocytapheresis compared to phlebotomy: A mathematical tool for predicting response in hereditary hemochromatosis, polycythemia vera, and secondary erythrocytosis. (24130064)
2013
5
Treatment target in polycythemia vera. (23594014)
2013
6
Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. (23152654)
2012
7
Evaluation of hemostatic balance in blood from patients with polycythemia vera by means of thromboelastography: the effect of isovolemic erythrocytapheresis. (22098131)
2012
8
How to manage polycythemia vera. (22157736)
2012
9
Initial bone marrow reticulin fibrosis in polycythemia vera exerts an impact on clinical outcome. (22246040)
2012
10
Polycythemia vera: gender-related phenotypic differences. (21660494)
2012
11
Allogeneic hematopoietic cell transplantation for advanced polycythemia vera and essential thrombocythemia. (22449610)
2012
12
Porokeratosis in patients with polycythemia rubra vera: a new side effect of hydroxyurea? (21812837)
2012
13
Anti-inflammatory cytokines hepatocyte growth factor and interleukin-11 are over-expressed in Polycythemia vera and contribute to the growth of clonal erythroblasts independently of JAK2V617F. (21042281)
2011
14
Severe reversible hyperkinesia due to polycythemia (Rubra) vera. (21412841)
2011
15
Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera. (20585043)
2010
16
A retrospective study on 226 polycythemia vera patients: impact of median hematocrit value on clinical outcomes and survival improvement with anti-thrombotic prophylaxis and non-alkylating drugs. (20146064)
2010
17
Histopathological manifestations of membranoproliferative glomerulonephritis and glomerular expression of plasmalemmal vesicle-associated protein-1 in a patient with polycythemia vera. (20979949)
2010
18
Treatment outcome in a cohort of young patients with polycythemia vera. (20607450)
2010
19
Clinical and hematological presentation of children and adolescents with polycythemia vera. (19468728)
2009
20
Hydroxyurea (HU) is effective in reducing JAK2V617F mutated clone size in the peripheral blood of essential thrombocythemia (ET) and polycythemia vera (PV) patients. (19096846)
2009
21
Thrombo-occlusion of inferior vena cava filter in a patient with polycythemia vera. (19782271)
2009
22
Symptomatic splenomegaly in polycythemia vera: a review of the indications for splenectomy and perioperative considerations. (19445284)
2009
23
The rare t(6;8) (q27;p11) translocation in a case of chronic myeloid neoplasm mimicking polycythemia vera. (18608868)
2008
24
Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations. (18195094)
2008
25
The revised World Health Organization diagnostic criteria for polycythemia vera, essential thrombocytosis, and primary myelofibrosis: an alternative proposal. (18401028)
2008
26
Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. (18394555)
2008
27
Therapy-related patterns of cytogenetic abnormalities in acute myeloid leukemia and myelodysplastic syndrome post polycythemia vera: single center experience and review of literature. (18351338)
2008
28
Postsurgery outcomes in patients with polycythemia vera and essential thrombocythemia: a retrospective survey. (17909074)
2008
29
JAK2 exon 12 mutation in JAK2V617F-negative polycythemia vera. (18297539)
2008
30
T cells from patients with polycythemia vera elaborate growth factors which contribute to endogenous erythroid and megakaryocyte colony formation. (17713553)
2007
31
Usefulness of JAK2V617F mutation in distinguishing idiopathic erythrocytosis from polycythemia vera. (16620973)
2007
32
Isolated monocular visual loss as an initial manifestation of polycythemia vera. (17466335)
2007
33
How I treat patients with polycythemia vera. (17264301)
2007
34
Apolipoprotein A1: A new serum marker correlated to JAK2 V617F proportion at diagnosis in patients with polycythemia vera. (21136658)
2007
35
Transformation of polycythemia vera to chronic myelogenous leukemia. (17979493)
2007
36
Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera. (17113348)
2007
37
Markers of myeloproliferative diseases in childhood polycythemia vera and essential thrombocythemia. (17369568)
2007
38
Polycythemia vera and its molecular basis: an update. (16781479)
2006
39
Clinical and laboratory features, pathobiology of platelet-mediated thrombosis and bleeding complications, and the molecular etiology of essential thrombocythemia and polycythemia vera: therapeutic implications. (16673274)
2006
40
t(3;12)(q26;q14) in polycythemia vera is associated with upregulation of the HMGA2 gene. (17024113)
2006
41
A refined diagnostic algorithm for polycythemia vera that incorporates mutation screening for JAK2(V617F). (20425336)
2006
42
Long-term effects of the treatment of polycythemia vera with recombinant interferon-alpha. (16804923)
2006
43
Interleukin-10 inhibits erythropoietin-independent growth of erythroid bursts in patients with polycythemia vera. (9731054)
1998
44
Expression of Bcl-x in erythroid precursors from patients with polycythemia vera. (9475763)
1998
45
The present state of pathophysiology and therapeutic trials in polycythemia vera. (8923777)
1996
46
Megakaryoblastic transformation associated with disseminated intravascular coagulation in the course of polycythemia vera: a case report]. (1602615)
1992
47
Chronic myelomonocytic leukemia transformation in polycythemia vera. (2072746)
1991
48
A clinical and biological study of 33 cases of polycythemia vera]. (2236766)
1990
49
Chronic neutrophilic leukemia associated with polycythemia vera. (2741931)
1989
50
Conversion of polycythemia vera to refractory anemia with hyperplastic bone marrow. (272208)
1978

Genetic Variations for Polycythemia Vera

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Polycythemia Vera:

62
id Symbol AA change Variation ID SNP ID
1JAK2p.Val617PheVAR_032697

Expression for genes affiliated with Polycythemia Vera

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polycythemia Vera

Search GEO for disease gene expression data for Polycythemia Vera.

Pathways for genes affiliated with Polycythemia Vera

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems
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Pathways related to Polycythemia Vera according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5PTPN6, EPOR, IFNA2, EPO, STAT5A, MPL
2
Hide members
10.5PF4, MPL, JAK2, IFNA1, CD177, IFNA2
310.5EPOR, JAK2, EPO
4
Development EPO-induced Jak-STAT pathway
Hide members
10.5SOCS3, JAK2, STAT5A, PTPN6, EPO, EPOR
5
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
10.5SOCS3, JAK2, JAK3, STAT5A, MPL, TYK2
610.5STAT5A, PTPN6, EPOR, EPO, JAK2
7
Hide members
10.5JAK2, PTPN6, EPO, EPOR, STAT5A
8
Hide members
10.5TYK2, SOCS3, JAK3, MPL, STAT5A, JAK2
910.5IFNA1, PDGFRB, JAK2, JAK3, IFNA2, EPO
1010.5CSF3R, EPOR, EPO, THPO
11
Hide members
10.5THPO, MPL, SOCS3
1210.5IFNA2, JAK2, SOCS3
1310.5SOCS3, JAK2, PTPN6
1410.5TYK2, SOCS3, JAK2
1510.5TYK2, SOCS3, JAK2
16
Hide members
10.5JAK3, JAK2, STAT5A, MPL, SOCS3
17
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10.5PF4, CSF3R, PDGFRB, THPO, PTPN6, JAK2
18
Hide members
10.5EPOR, IFNA1, SOCS3, PDGFRB, CSF3R, JAK2
1910.5JAK2, SOCS3, PDGFRB, TYK2
20
Hide members
10.5JAK2, JAK3, STAT5A, THPO, PDGFRB, EPOR
21
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.5JAK2, SOCS3, JAK3, TYK2
2210.5JAK2, IFNA1, IFNA2, TYK2
2310.5SOCS3, JAK2, STAT5A, PTPN6
24
Hide members
10.5STAT5A, SOCS3, JAK2, PTPN6
2510.5PTPN6, STAT5A, JAK2
26
Hide members
10.5SOCS3, JAK2, STAT5A, TYK2, PTPN6, JAK3
2710.5PTPN6, STAT5A, JAK3, JAK2, TYK2, SOCS3
2810.5STAT5A, SOCS3, JAK2, JAK3, PTPN6
29
Immune response IL-2 activation and signaling pathway
Hide members
10.5SOCS3, JAK2, JAK3, STAT5A, PTPN6
30
Hide members
10.5SOCS3, JAK2, JAK3, PTPN6, STAT5A, TYK2
31
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
10.5SOCS3, STAT5A, TYK2, JAK2
3210.5SOCS3, JAK2, TYK2, STAT5A
33
Hide members
10.5JAK2, JAK3, STAT5A, EPOR, PF4, PDGFRB
34
Hide members
10.5JAK3, THPO, CSF3R, STAT5A, PDGFRB, PF4
35
Hide members
10.5JAK2, STAT5A, PTPN6, PDGFRB
36
Immune response IFN alpha/beta signaling pathway
Hide members
10.5TYK2, IFNA2
37
Development PDGF signaling via STATs and NF-kB
Hide members
10.5TYK2, JAK2, PDGFRB, SOCS3, STAT5A
3810.5PDGFRB, SOCS3, TYK2, JAK2, STAT5A
39
Hide members
10.5JAK2, TYK2, STAT5A
4010.5JAK2, JAK3, SOCS3, STAT5A, TYK2
41
Hide members
10.5IFNA1, IFNA2, JAK3, STAT5A, TYK2, JAK2
4210.5IFNA1, TYK2, IFNA2, SOCS3
43
Hide members
10.5SOCS3, STAT5A, JAK3, IFNA2, IFNA1, TYK2
4410.5TYK2, STAT5A, JAK2, JAK3
45
Hide members
10.5TYK2, STAT5A, JAK3, JAK2
4610.5PTPN6, SOCS3, STAT5A, TYK2
4710.5STAT5A, TYK2, SOCS3
48
Hide members
10.5JAK3, STAT5A, SOCS3
4910.5JAK3, STAT5A, PDGFRB
5010.5STAT5A, ACP1, PDGFRB

Compounds for genes affiliated with Polycythemia Vera

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Polycythemia Vera according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.0ACP1, THPO, THBD, PF4, EPO, CD177
2gp 1304411.0SOCS3, PDGFRB, CSF3R, JAK2, JAK3, STAT5A
3anagrelide44 1112.0EPO, PF4, THPO, MPL, JAK2, IFNA1
4phosphatidylinositol4410.9SOCS3, MPL, ACP1, THPO, PTPN6, CSF3R
5vegf4410.9IFNA2, IFNA1, PDGFRB, CSF3R, JAK2, JAK3
6alanine4410.9PTPN6, IFNA2, IFNA1, PDGFRB, CSF3R, JAK2
7thymidine44 2411.9STAT5A, THPO, PTPN6, PF4, EPOR, EPO
8serine4410.9SOCS3, MPL, EPOR, JAK3, PTPN6, JAK2
9agar4410.9PDGFRB, JAK2, STAT5A, MPL, EPOR, PF4
10phosphotyrosine4410.9SOCS3, PTPN6, TYK2, ACP1, STAT5A, EPOR
11ly2940024410.9JAK2, PDGFRB, ACP1, JAK3, EPO, STAT5A
12retinoic acid44 2411.9JAK2, THBD, HMGA2, TYK2, STAT5A, CSF3R
13cysteine4410.9JAK2, MPL, THPO, IFNA2, PDGFRB, PTPN6
14wortmannin4410.9THPO, STAT5A, PF4, EPOR, TYK2, JAK3
15estrogen4410.9JAK3, THPO
16imatinib44 49 1112.9CSF3R, PDGFRB, IFNA1, JAK2, THPO, EPO
17hydroxyurea44 49 1112.9PF4, EPO, JAK2, IFNA1, IFNA2, THPO
18polyethylene glycol4410.9THPO, PF4, MPL, IFNA2, THBD, IFNA1
19vanadate4410.9PDGFRB, ACP1, JAK2, PTPN6, TYK2, STAT5A
20phenylalanine4410.9EPOR, PDGFRB, CSF3R, JAK2, JAK3, STAT5A
21genistein44 28 59 2 11 2415.9STAT5A, JAK2, THPO, CSF3R, PTPN6, ACP1
22cytarabine44 49 1112.9IFNA1, PTPN6, THPO, EPO, STAT5A, IFNA2
23oligonucleotide4410.9PDGFRB, SOCS3, PTPN6, THPO, THBD, CSF3R
24oxygen44 2411.9JAK2, CSF3R, EPOR, PF4, STAT5A, EPO
25sodium orthovanadate44 5911.9ACP1, JAK2, STAT5A, TYK2, PTPN6
26cisplatin44 49 59 1113.9EPO, EPOR, HMGA2, ACP1, JAK2, PDGFRB
27glucose4410.9SOCS3, PTPN6, THBD, IFNA2, PF4, PDGFRB
28filgrastim44 1111.8CSF3R, IFNA2, EPO, THPO
29aspartate4410.8ACP1, JAK2, PTPN6, STAT5A
30ifn-alpha4410.8STAT5A, SOCS3, IFNA1, IFNA2, TYK2
31rapamycin4410.8THPO, IFNA1, STAT5A, JAK2, EPO, PDGFRB
32adp44 28 2412.8PF4, JAK2, TYK2, MPL
335-aza-2deoxycytidine4410.8JAK2, EPO, SOCS3, THPO, PTPN6, IFNA1
34cycloheximide4410.8JAK3, IFNA1
35lipid4410.8IFNA2, SOCS3, PDGFRB, JAK3, STAT5A, EPOR
363-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile1110.8JAK3, TYK2, JAK2
375fluorouracil4410.8MPL, PDGFRB, IFNA1, PF4, THPO, IFNA2
38cyclosporin a44 28 5912.7EPO, IFNA1, STAT5A, JAK2, JAK3, ACP1
39lysine4410.7THPO, CSF3R, MPL, JAK2, SOCS3, PF4
402-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE1110.7TYK2, JAK3, JAK2
41pp 1004410.7EPOR, JAK2, EPO
42etoposide44 49 59 1113.7STAT5A, IFNA2, IFNA1, ACP1, PF4, THPO
43nitric oxide44 11 2412.6JAK3, PTPN6, STAT5A, JAK2, SOCS3, EPOR
44indomethacin44 59 28 1113.6ACP1, PF4
45threonine4410.6MPL, STAT5A, JAK3, JAK2, PDGFRB, TYK2
46mycophenolate mofetil44 49 1112.5THBD, IFNA1, JAK3, EPO
47methylcellulose4410.5THPO, CSF3R, EPO, EPOR
48ribavirin44 49 1112.5SOCS3, EPO, IFNA2, IFNA1
49herbimycin a44 5911.4JAK2, JAK3, ACP1, STAT5A, PTPN6
50h2o24410.2PTPN6, ACP1, THPO, THBD, TYK2, JAK2

GO Terms for genes affiliated with Polycythemia Vera

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Sources:
16Gene Ontology
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Biological processes related to Polycythemia Vera according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759610.8IFNA2, JAK2, MPL, CD177, PF4, THBD
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.8PTPN6, STAT5A, JAK3, JAK2, SOCS3
3peptidyl-tyrosine phosphorylationGO:01810810.8PDGFRB, JAK2, JAK3, STAT5A, PTPN6
4regulation of type I interferon-mediated signaling pathwayGO:06033810.8IFNA2, SOCS3, TYK2, PTPN6
5cytokine-mediated signaling pathwayGO:01922110.8IFNA2, SOCS3, JAK2, TYK2, PF4, PTPN6
6type I interferon-mediated signaling pathwayGO:06033710.7IFNA2, SOCS3, TYK2, PTPN6
7regulation of interferon-gamma-mediated signaling pathwayGO:06033410.7PTPN6, JAK2, SOCS3
8intracellular protein kinase cascadeGO:00724310.7PDGFRB, JAK2, JAK3, TYK2
9JAK-STAT cascadeGO:00725910.7STAT5A, JAK2, SOCS3
10tyrosine phosphorylation of STAT proteinGO:00726010.7JAK3, JAK2
11positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.6PDGFRB, JAK2, PTPN6
12STAT protein import into nucleusGO:00726210.6JAK3, JAK2
13mammary gland epithelium developmentGO:06118010.5STAT5A, JAK2
14interferon-gamma-mediated signaling pathwayGO:06033310.5SOCS3, JAK2, PTPN6
15response to hyperoxiaGO:05509310.5EPO, PDGFRB
16positive regulation of phosphoprotein phosphatase activityGO:03251610.4JAK2, PDGFRB
17enzyme linked receptor protein signaling pathwayGO:00716710.2JAK3, JAK2

Molecular functions related to Polycythemia Vera according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.5PTPN6, IFNA2, SOCS3, PDGFRB, CSF3R, JAK2
2growth hormone receptor bindingGO:00513110.5TYK2, JAK2
3protein tyrosine kinase activityGO:00471310.4PDGFRB, JAK2, JAK3, TYK2
4non-membrane spanning protein tyrosine kinase activityGO:00471510.2TYK2, JAK3, JAK2

Products for genes affiliated with Polycythemia Vera

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polycythemia Vera

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet