PV
MCID: PLY001
MIFTS: 83

Polycythemia Vera (PV) malady

Cancer diseases, Blood diseases categories

Summaries for Polycythemia Vera

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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Genetics Home Reference:21 Polycythemia vera is a condition characterized by an increased number of red blood cells in the bloodstream. Affected individuals may also have excess white blood cells and blood clotting cells called platelets. These extra cells cause the blood to be thicker than normal. As a result, abnormal blood clots are more likely to form and block the flow of blood through arteries and veins. Individuals with polycythemia vera have an increased risk of deep vein thrombosis (DVT), a type of blood clot that occurs in the deep veins of the arms or legs. If a DVT travels through the bloodstream and lodges in the lungs, it can cause a life-threatening clot known as a pulmonary embolism (PE). Affected individuals also have an increased risk of heart attack and stroke caused by blood clots in the heart and brain.

MalaCards: Polycythemia Vera, also known as PV, is related to polycythemia and myelofibrosis, and has symptoms including gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia, weight loss/loss of appetite/break in weight curve/general health alteration and transient cerebral ischemia/stroke. An important gene associated with Polycythemia Vera is JAK2 (Janus kinase 2), and among its related pathways are Jak-STAT signaling pathway and Platelet activation, signaling and aggregation. The drugs busulfan and hydroxyurea and the compounds tyrosine and gp 130 have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and myeloid, and related mouse phenotypes are hematopoietic system and immune system.

NIH Rare Diseases:42 Polycythemia vera (pcv) is a condition characterized by an increased number of red blood cells in the bloodstream. affected people may also have excess white blood cells and platelets. these extra cells cause the blood to be thicker than normal, increasing the risk for blood clots that can block blood flow in arteries and veins. people with pcv have an increased risk of deep vein thrombosis which can cause a pulmonary embolism; heart attack; and stroke. most cases are not inherited and are acquired during a person's lifetime. in rare cases, the risk for pcv runs in families and may be inherited in an autosomal dominant manner. the condition has been associated with mutations in the jak2 and tet2 genes. last updated: 3/17/2014

Wikipedia:63 Polycythemia (or Polycythaemia, see spelling differences) vera (PV, PCV) (also known as erythremia,... more...

Description from OMIM:46 263300

Aliases & Classifications for Polycythemia Vera

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
polycythemia vera:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

polycythemia vera 8 9 42 22 21 46 10 44 48 60
pv 42 21 48
polycythemia rubra vera 42 48
primary polycythemia 42 21
osler-vaquez disease 21 48
erythremia 8 48
prv 42 21
acquired primary erythocytosis 48
proliferative polycythaemia 8
polycythaemia rubra vera 8
polycythemia ruba vera 21
osler-vaquez syndrome 8
vaquez disease 48


External Ids:

Disease Ontology8 DOID:8997
NCIt39 C3336
ICD9CM27 238.4
OMIM46 263300
MeSH34 D011087
MESH via Orphanet35 D011087
ICD10 via Orphanet26 D45
SNOMED-CT via Orphanet57 109992005, 128841001
UMLS via Orphanet61 C0032463
ICD1025 D45

Related Diseases for Polycythemia Vera

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17GeneCards, 18GeneDecks
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Diseases related to Polycythemia Vera via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1polycythemia32.2THPO, EPOR, EPO, CD177, MPL, STAT5A
2myelofibrosis31.5JAK2, MPL, EPO, THPO
3primary polycythemia31.3JAK2, STAT5A, EPO, EPOR
4leukemia31.2PTPN6, IFNA2, TET2, ACP1, THPO, HMGA2
5thrombocytosis30.9IFNA2, IFNA1, TET2, THPO, THBD, PF4
6myeloid leukemia30.8PTPN6, SOCS3, CSF3R, JAK2, JAK3, STAT5A
7acute leukemia30.7EPO, MPL, STAT5A, JAK2, CSF3R, EPOR
8chronic myeloid leukemia30.6PTPN6, THPO, EPOR, EPO, CD177, MPL
9thrombocytopenia30.6IFNA2, IFNA1, MPL, EPO, PF4, THBD
10acquired polycythemia30.5JAK2, EPO, EPOR
11ischemia30.5PF4, EPOR, JAK2, SOCS3
12hepatitis30.5THPO, IFNA1, IFNA2
13gastrointestinal stromal tumor30.4JAK3, PDGFRB
14glomerulonephritis30.3EPOR
15hemorrhagic thrombocythemia30.3CD177
16myocardial infarction30.3PF4
17thrombophilia30.3THBD, PF4
18erythromelalgia30.3THBD, PF4
19myeloma30.2EPOR, EPO, TYK2, STAT5A, JAK2, IFNA1
20deficiency anemia30.1IFNA2, IFNA1, CSF3R, JAK2, MPL, EPO
21chronic myeloproliferative disease30.1THPO, MPL, JAK2, PDGFRB
22sarcoma30.1PDGFRB, JAK2, HMGA2, THPO, ACP1
23portal vein thrombosis30.1THPO
24purpura30.1THPO
25disseminated intravascular coagulation30.1THPO, THBD, PF4
26vasculitis30.1IFNA2, THBD
27eosinophilia30.1IFNA2, PDGFRB, JAK2
28acute myocardial infarction30.1THBD, PF4
29tuberculosis30.1ACP1, PF4
30pancytopenia30.1MPL, EPO, THPO
31polyneuropathy30.1IFNA2
32atherosclerosis30.1ACP1, THBD, PF4, PDGFRB, SOCS3
33pulmonary embolism30.1PF4
34thyroiditis30.1IFNA1
35ovarian cancer29.9PDGFRB, JAK2, JAK3, ACP1, PTPN6
36neuroblastoma29.9CD177
37malaria29.9ACP1
38erythropoietin polycythemia10.7
39cerebritis10.4
40acute myeloid leukemia10.4
41splenic infarction10.4
42focal segmental glomerulosclerosis10.3
43hemochromatosis10.3
44focal glomerulosclerosis10.3
45chronic lymphocytic leukemia10.3
46hairy cell leukemia10.3
47osteonecrosis10.3
48coronary thrombosis10.3
49glossitis10.3
50axonal neuropathy10.3

Graphical network of the top 20 diseases related to Polycythemia Vera:



Diseases related to polycythemia vera

Clinical Features for Polycythemia Vera

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46OMIM, 48Orphanet
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Clinical features from OMIM:

263300

Clinical synopsis from OMIM:

263300

Symptoms:

48 (show all 25)
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • transient cerebral ischemia/stroke
  • venous thrombosis/phlebitis/thrombophlebitis
  • arterial embolism/thrombosis
  • portal hypertension
  • pruritus/itching
  • dizziness
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • ecchymoses
  • acute abdominal pain/colic
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • angor pectoris/myocardial infarction
  • chronic arterial hypertension
  • facial pain/cephalalgia/migraine
  • epistaxis/nose bleeding
  • gingivorrhagia/gingival bleeding
  • acute leukemia
  • myelodysplastic syndrome
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • articular/joint pain/arthralgia
  • asthenia/fatigue/weakness
  • claudication/pain on mastication/while chewing
  • tinnitus

Drugs & Therapeutics for Polycythemia Vera

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Polycythemia Vera

Drug clinical trials:

Search ClinicalTrials for Polycythemia Vera

Search NIH Clinical Center for Polycythemia Vera

Search CenterWatch for Polycythemia Vera

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Polycythemia Vera

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22GTR
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Genetic tests related to Polycythemia Vera:

id Genetic test Affiliating Genes
1 Polycythemia Vera22

Anatomical Context for Polycythemia Vera

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32MalaCards
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MalaCards organs/tissues related to Polycythemia Vera:

32
Heart, Bone, Myeloid, Bone marrow, Lung, Brain, Endothelial, Liver, Testes, B cells, T cells, Skin, Whole blood, Monocytes, Spinal cord, Prostate

Animal Models for Polycythemia Vera or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polycythemia Vera:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.7PTPN6, SOCS3, PDGFRB, CSF3R, JAK2, JAK3
2MP:000538710.7STAT5A, JAK3, JAK2, CSF3R, PDGFRB, SOCS3
3MP:000538410.7STAT5A, JAK3, JAK2, CSF3R, PDGFRB, SOCS3
4MP:000537610.7SOCS3, PDGFRB, JAK2, STAT5A, MPL, TYK2
5MP:001076810.6STAT5A, JAK3, JAK2, PDGFRB, SOCS3, MPL
6MP:001077110.5SOCS3, HMGA2
7MP:000287310.5SOCS3, PDGFRB, JAK2, STAT5A, EPO, EPOR
8MP:000538010.5THBD, EPOR, SOCS3
9MP:000537810.4SOCS3, PDGFRB, JAK2, STAT5A, MPL, HMGA2
10MP:000537010.2SOCS3, STAT5A, EPO, EPOR, THBD, TET2

Publications for Polycythemia Vera

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50PubMed
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Articles related to Polycythemia Vera:

(show top 50)    (show all 660)
idTitleAuthorsYear
1
Complex karyotype in a polycythemia vera patient with a novel SETD1B/GTF2H3 fusion gene. (24382738)
2014
2
IgG-lymphoplasmacytic lymphoma following polycythemia vera: JAK2 V617F and MYD88 L265P mutations separated in the same house. (24408161)
2014
3
Macrophages support pathological erythropoiesis in polycythemia vera and I^-thalassemia. (23502961)
2013
4
Long term molecular responses in a cohort of Danish patients with essential thrombocythemia, polycythemia vera and myelofibrosis treated with recombinant interferon alpha. (23827351)
2013
5
Aquagenic pruritus in polycythemia vera: characteristics and influence on quality of life in 441 patients. (23657863)
2013
6
Chorea and a frontal lobe syndrome: a rare neurological presentation of polycythemia vera; a case report. (22409737)
2012
7
Changes in advanced oxidation protein products, advanced glycation end products, and s-nitrosylated proteins, in patients affected by polycythemia vera and essential thrombocythemia. (22850610)
2012
8
Convergent mechanisms of somatic mutations in polycythemia vera. (21794206)
2011
9
Narrative review: Thrombocytosis, polycythemia vera, and JAK2 mutations: The phenotypic mimicry of chronic myeloproliferation. (20194236)
2010
10
JAK2 Negative Polycythemia Vera. (21346910)
2010
11
Can ischemia-modified albumin be a valuable indicator of tissue ischemia in polycythemia vera? (20557673)
2010
12
Spontaneous spinal epidural hematoma as the initial presentation of polycythemia vera. (19940468)
2010
13
Polycythemia vera as a presentation of renal angiomyolipoma: a case report. (19946506)
2009
14
Perspectives on thrombosis in essential thrombocythemia and polycythemia vera: is leukocytosis a causative factor? (19372254)
2009
15
JAK2V617F mutational status and allele burden have little influence on clinical phenotype and prognosis in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis. (19042918)
2009
16
JAK2 V617F/C618R mutation in a patient with polycythemia vera: a case study and review of the literature. (19167611)
2009
17
Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a. (19497108)
2009
18
Prevalence of polycythemia vera and essential thrombocythemia. (18181200)
2008
19
Polycythemia vera presenting with bilateral papilledema: a rare case report. (18579996)
2008
20
Essential thrombocythemia, polycythemia vera, and myelofibrosis: current management and the prospect of targeted therapy. (18429051)
2008
21
Inhibitory effect of the substance P and its derivative on erythropoietin-independent growth of erythroid progenitors in polycythemia vera. (17980427)
2008
22
JAK2 V617F positive polycythemia Vera in a child with neurofibromatosis type I. (18623221)
2008
23
The significance of bone marrow biopsy and JAK2V617F mutation in the differential diagnosis between the "early" prepolycythemic phase of polycythemia vera and essential thrombocythemia. (18701405)
2008
24
Identification of JAK2V617F in patients with polycythemia is highly correlated with conventional criteria for diagnosis of polycythemia vera. (16924638)
2007
25
Anticoagulation after coronary artery surgery in patients with polycythemia vera: report of two cases. (17803581)
2007
26
Hematopoietic cell transplantation as curative therapy for idiopathic myelofibrosis, advanced polycythemia vera, and essential thrombocythemia. (17317589)
2007
27
Synovial tumefactive extramedullary hematopoiesis associated to polycythemia vera. (17109152)
2007
28
The revised WHO diagnostic criteria for Ph-negative myeloproliferative diseases are not appropriate for the diagnostic screening of childhood polycythemia vera and essential thrombocythemia. (17644735)
2007
29
A phase II trial of tipifarnib in myelofibrosis: primary, post-polycythemia vera and post-essential thrombocythemia. (17581608)
2007
30
Uncontrolled thrombocytosis in polycythemia vera is a risk for thrombosis, regardless of JAK2(V617F) mutational status. (17611562)
2007
31
JAK2 mutations in polycythemia vera--molecular mechanisms and clinical applications. (17267904)
2007
32
JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis. (18056003)
2007
33
The diagnosis of polycythemia vera: new tests and old dictums. (16781483)
2006
34
Risk stratification, staging, and treatment of patients with polycythemia vera: Italian and European collaboration on low-dose aspirin in polycythemia data. (16673282)
2006
35
Translocation (2;11)(p21;q23) in a patient with polycythemia vera: a novel clonal chromosome abnormality. (16804938)
2006
36
Evidence-based management of polycythemia vera. (16781485)
2006
37
Clinical features of polycythemia vera and essential thrombocythemia in Japan: retrospective analysis of a nationwide survey by the Japanese Elderly Leukemia and Lymphoma Study Group. (16787877)
2006
38
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. (15837627)
2005
39
Carcinoid tumor of the duodenum and accessory papilla associated with polycythemia vera. (15968742)
2005
40
Hydroxyurea vindicated: lack of drug leukemogenicity in polycythemia vera. (15865873)
2005
41
Diagnostic approaches to polycythemia vera in 2004. (15225097)
2004
42
Current evaluation of the clinical, diagnostic, and therapeutic usefulness of prv-1 and c-mpl markers in polycythemia vera and essential thrombocythemia. (16163180)
2004
43
Effect of diroton on characteristics of 24-hours arterial pressure monitoring in hypertensive patients with polycythemia vera]. (14520846)
2003
44
Acute leucocytoclastic vasculitis and aquagenic pruritus long preceding polycythemia rubra vera. (11978570)
2002
45
Replication status in leukocytes of treated and untreated patients with polycythemia vera and essential thrombocytosis. (11890987)
2002
46
Chronic neutrophilic leukemia evolving from polycythemia vera with multiple chromosome rearrangements: a case report. (11694412)
2001
47
Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders. (11242597)
2001
48
Platelet density in essential thrombocythemia and polycythemia vera. (16801072)
1999
49
Brachial plexopathy and Horner's syndrome as the first manifestations of internal jugular vein thrombosis inaugurating polycythemia vera. (9636957)
1998
50
Identification of increased protein tyrosine phosphatase activity in polycythemia vera erythroid progenitor cells. (9226165)
1997

Genetic Variations for Polycythemia Vera

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Polycythemia Vera:

62
id Symbol AA change Variation ID SNP ID
1JAK2p.Val617PheVAR_032697

Expression for genes affiliated with Polycythemia Vera

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polycythemia Vera

Search GEO for disease gene expression data for Polycythemia Vera.

Pathways for genes affiliated with Polycythemia Vera

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems
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Pathways related to Polycythemia Vera according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5PTPN6, EPOR, IFNA2, EPO, STAT5A, MPL
2
Hide members
10.5PF4, MPL, JAK2, IFNA1, CD177, IFNA2
310.5EPOR, JAK2, EPO
4
Development EPO-induced Jak-STAT pathway
Hide members
10.5SOCS3, JAK2, STAT5A, PTPN6, EPO, EPOR
5
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
10.5SOCS3, JAK2, JAK3, STAT5A, MPL, TYK2
610.5STAT5A, PTPN6, EPOR, EPO, JAK2
7
Hide members
10.5JAK2, PTPN6, EPO, EPOR, STAT5A
8
Hide members
10.5TYK2, SOCS3, JAK3, MPL, STAT5A, JAK2
910.5IFNA1, PDGFRB, JAK2, JAK3, IFNA2, EPO
1010.5CSF3R, EPOR, EPO, THPO
11
Hide members
10.5THPO, MPL, SOCS3
1210.5IFNA2, JAK2, SOCS3
1310.5SOCS3, JAK2, PTPN6
1410.5TYK2, SOCS3, JAK2
1510.5TYK2, SOCS3, JAK2
16
Hide members
10.5JAK3, JAK2, STAT5A, MPL, SOCS3
17
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10.5PF4, CSF3R, PDGFRB, THPO, PTPN6, JAK2
18
Hide members
10.5EPOR, IFNA1, SOCS3, PDGFRB, CSF3R, JAK2
1910.5JAK2, SOCS3, PDGFRB, TYK2
20
Hide members
10.5JAK2, JAK3, STAT5A, THPO, PDGFRB, EPOR
21
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.5JAK2, SOCS3, JAK3, TYK2
2210.5JAK2, IFNA1, IFNA2, TYK2
2310.5SOCS3, JAK2, STAT5A, PTPN6
24
Hide members
10.5STAT5A, SOCS3, JAK2, PTPN6
2510.5PTPN6, STAT5A, JAK2
26
Hide members
10.5SOCS3, JAK2, STAT5A, TYK2, PTPN6, JAK3
2710.5PTPN6, STAT5A, JAK3, JAK2, TYK2, SOCS3
2810.5STAT5A, SOCS3, JAK2, JAK3, PTPN6
29
Immune response IL-2 activation and signaling pathway
Hide members
10.5SOCS3, JAK2, JAK3, STAT5A, PTPN6
30
Hide members
10.5SOCS3, JAK2, JAK3, PTPN6, STAT5A, TYK2
31
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
10.5SOCS3, STAT5A, TYK2, JAK2
3210.5SOCS3, JAK2, TYK2, STAT5A
33
Hide members
10.5JAK2, JAK3, STAT5A, EPOR, PF4, PDGFRB
34
Hide members
10.5JAK3, THPO, CSF3R, STAT5A, PDGFRB, PF4
35
Hide members
10.5JAK2, STAT5A, PTPN6, PDGFRB
36
Immune response IFN alpha/beta signaling pathway
Hide members
10.5TYK2, IFNA2
37
Development PDGF signaling via STATs and NF-kB
Hide members
10.5TYK2, JAK2, PDGFRB, SOCS3, STAT5A
3810.5PDGFRB, SOCS3, TYK2, JAK2, STAT5A
39
Hide members
10.5JAK2, TYK2, STAT5A
4010.5JAK2, JAK3, SOCS3, STAT5A, TYK2
41
Hide members
10.5IFNA1, IFNA2, JAK3, STAT5A, TYK2, JAK2
4210.5IFNA1, TYK2, IFNA2, SOCS3
43
Hide members
10.5SOCS3, STAT5A, JAK3, IFNA2, IFNA1, TYK2
4410.5TYK2, STAT5A, JAK2, JAK3
45
Hide members
10.5TYK2, STAT5A, JAK3, JAK2
4610.5PTPN6, SOCS3, STAT5A, TYK2
4710.5STAT5A, TYK2, SOCS3
48
Hide members
10.5JAK3, STAT5A, SOCS3
4910.5JAK3, STAT5A, PDGFRB
5010.5STAT5A, ACP1, PDGFRB

Compounds for genes affiliated with Polycythemia Vera

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Polycythemia Vera according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.0ACP1, THPO, THBD, PF4, EPO, CD177
2gp 1304411.0SOCS3, PDGFRB, CSF3R, JAK2, JAK3, STAT5A
3anagrelide44 1112.0EPO, PF4, THPO, MPL, JAK2, IFNA1
4phosphatidylinositol4410.9SOCS3, MPL, ACP1, THPO, PTPN6, CSF3R
5vegf4410.9IFNA2, IFNA1, PDGFRB, CSF3R, JAK2, JAK3
6alanine4410.9PTPN6, IFNA2, IFNA1, PDGFRB, CSF3R, JAK2
7thymidine44 2411.9STAT5A, THPO, PTPN6, PF4, EPOR, EPO
8serine4410.9SOCS3, MPL, EPOR, JAK3, PTPN6, JAK2
9agar4410.9PDGFRB, JAK2, STAT5A, MPL, EPOR, PF4
10phosphotyrosine4410.9SOCS3, PTPN6, TYK2, ACP1, STAT5A, EPOR
11ly2940024410.9JAK2, PDGFRB, ACP1, JAK3, EPO, STAT5A
12retinoic acid44 2411.9JAK2, THBD, HMGA2, TYK2, STAT5A, CSF3R
13cysteine4410.9JAK2, MPL, THPO, IFNA2, PDGFRB, PTPN6
14wortmannin4410.9THPO, STAT5A, PF4, EPOR, TYK2, JAK3
15estrogen4410.9JAK3, THPO
16imatinib44 49 1112.9CSF3R, PDGFRB, IFNA1, JAK2, THPO, EPO
17hydroxyurea44 49 1112.9PF4, EPO, JAK2, IFNA1, IFNA2, THPO
18polyethylene glycol4410.9THPO, PF4, MPL, IFNA2, THBD, IFNA1
19vanadate4410.9PDGFRB, ACP1, JAK2, PTPN6, TYK2, STAT5A
20phenylalanine4410.9EPOR, PDGFRB, CSF3R, JAK2, JAK3, STAT5A
21genistein44 28 59 2 11 2415.9STAT5A, JAK2, THPO, CSF3R, PTPN6, ACP1
22cytarabine44 49 1112.9IFNA1, PTPN6, THPO, EPO, STAT5A, IFNA2
23oligonucleotide4410.9PDGFRB, SOCS3, PTPN6, THPO, THBD, CSF3R
24oxygen44 2411.9JAK2, CSF3R, EPOR, PF4, STAT5A, EPO
25sodium orthovanadate44 5911.9ACP1, JAK2, STAT5A, TYK2, PTPN6
26cisplatin44 49 59 1113.9EPO, EPOR, HMGA2, ACP1, JAK2, PDGFRB
27glucose4410.9SOCS3, PTPN6, THBD, IFNA2, PF4, PDGFRB
28filgrastim44 1111.8CSF3R, IFNA2, EPO, THPO
29aspartate4410.8ACP1, JAK2, PTPN6, STAT5A
30ifn-alpha4410.8STAT5A, SOCS3, IFNA1, IFNA2, TYK2
31rapamycin4410.8THPO, IFNA1, STAT5A, JAK2, EPO, PDGFRB
32adp44 28 2412.8PF4, JAK2, TYK2, MPL
335-aza-2deoxycytidine4410.8JAK2, EPO, SOCS3, THPO, PTPN6, IFNA1
34cycloheximide4410.8JAK3, IFNA1
35lipid4410.8IFNA2, SOCS3, PDGFRB, JAK3, STAT5A, EPOR
363-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile1110.8JAK3, TYK2, JAK2
375fluorouracil4410.8MPL, PDGFRB, IFNA1, PF4, THPO, IFNA2
38cyclosporin a44 28 5912.7EPO, IFNA1, STAT5A, JAK2, JAK3, ACP1
39lysine4410.7THPO, CSF3R, MPL, JAK2, SOCS3, PF4
402-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE1110.7TYK2, JAK3, JAK2
41pp 1004410.7EPOR, JAK2, EPO
42etoposide44 49 59 1113.7STAT5A, IFNA2, IFNA1, ACP1, PF4, THPO
43nitric oxide44 11 2412.6JAK3, PTPN6, STAT5A, JAK2, SOCS3, EPOR
44indomethacin44 59 28 1113.6ACP1, PF4
45threonine4410.6MPL, STAT5A, JAK3, JAK2, PDGFRB, TYK2
46mycophenolate mofetil44 49 1112.5THBD, IFNA1, JAK3, EPO
47methylcellulose4410.5THPO, CSF3R, EPO, EPOR
48ribavirin44 49 1112.5SOCS3, EPO, IFNA2, IFNA1
49herbimycin a44 5911.4JAK2, JAK3, ACP1, STAT5A, PTPN6
50h2o24410.2PTPN6, ACP1, THPO, THBD, TYK2, JAK2

GO Terms for genes affiliated with Polycythemia Vera

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Sources:
16Gene Ontology
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Biological processes related to Polycythemia Vera according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759610.8IFNA2, JAK2, MPL, CD177, PF4, THBD
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.8PTPN6, STAT5A, JAK3, JAK2, SOCS3
3peptidyl-tyrosine phosphorylationGO:01810810.8PDGFRB, JAK2, JAK3, STAT5A, PTPN6
4regulation of type I interferon-mediated signaling pathwayGO:06033810.8IFNA2, SOCS3, TYK2, PTPN6
5cytokine-mediated signaling pathwayGO:01922110.8IFNA2, SOCS3, JAK2, TYK2, PF4, PTPN6
6type I interferon-mediated signaling pathwayGO:06033710.7IFNA2, SOCS3, TYK2, PTPN6
7regulation of interferon-gamma-mediated signaling pathwayGO:06033410.7PTPN6, JAK2, SOCS3
8intracellular protein kinase cascadeGO:00724310.7PDGFRB, JAK2, JAK3, TYK2
9JAK-STAT cascadeGO:00725910.7STAT5A, JAK2, SOCS3
10tyrosine phosphorylation of STAT proteinGO:00726010.7JAK3, JAK2
11positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.6PDGFRB, JAK2, PTPN6
12STAT protein import into nucleusGO:00726210.6JAK3, JAK2
13mammary gland epithelium developmentGO:06118010.5STAT5A, JAK2
14interferon-gamma-mediated signaling pathwayGO:06033310.5SOCS3, JAK2, PTPN6
15response to hyperoxiaGO:05509310.5EPO, PDGFRB
16positive regulation of phosphoprotein phosphatase activityGO:03251610.4JAK2, PDGFRB
17enzyme linked receptor protein signaling pathwayGO:00716710.2JAK3, JAK2

Molecular functions related to Polycythemia Vera according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.5PTPN6, IFNA2, SOCS3, PDGFRB, CSF3R, JAK2
2growth hormone receptor bindingGO:00513110.5TYK2, JAK2
3protein tyrosine kinase activityGO:00471310.4PDGFRB, JAK2, JAK3, TYK2
4non-membrane spanning protein tyrosine kinase activityGO:00471510.2TYK2, JAK3, JAK2

Products for genes affiliated with Polycythemia Vera

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polycythemia Vera

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet