MCID: PLY006
MIFTS: 56

Polydactyly malady

Categories: Rare diseases, Bone diseases, Fetal diseases

Aliases & Classifications for Polydactyly

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Aliases & Descriptions for Polydactyly:

Name: Polydactyly 11 46 13 25 48 37
Polydactyly, Postaxial 48 37 66
Postaxial Polydactyly 11 25
Supernumerary Digits 46
Supernumerary Digit 11
 
Polydactylism 46
Extra Digits 46
Polydactylia 46
Hyperdactyly 46

Classifications:



External Ids:

Disease Ontology11 DOID:1148
ICD1028 Q69, Q69.9
ICD9CM30 755.0, 755.00
NCIt43 C87110

Summaries for Polydactyly

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NIH Rare Diseases:46 Polydactyly is a condition in which a person has more than five fingers per hand or five toes per foot. it is the most common birth defect of the hand and foot. polydactyly can occur as an isolated finding such that the person has no other physical anomalies or intellectual impairment. however, it can occur in association with other birth defects and cognitive abnormalities as part of a genetic syndrome. in some cases, the extra digits may be well-formed and functional. surgery may be considered especially for poorly formed digits or very large extra digits. surgical management depends greatly on the complexity of the deformity. last updated: 5/8/2015

MalaCards based summary: Polydactyly, also known as polydactyly, postaxial, is related to polydactyly, preaxial type ii and hypoplastic or aplastic tibia with polydactyly. An important gene associated with Polydactyly is MIPOL1 (Mirror-Image Polydactyly 1), and among its related pathways are Hedgehog Pathway and Cargo trafficking to the periciliary membrane. Affiliated tissues include heart, kidney and brain, and related mouse phenotypes are taste/olfaction and hearing/vestibular/ear.

Wikipedia:69 Polydactyly or polydactylism (from Greek πολύς (polys), meaning \"many\", and δάκτυλος... more...

Related Diseases for Polydactyly

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Diseases in the Polydactyly family:

Central Polydactyly of Toes

Diseases related to Polydactyly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 334)
idRelated DiseaseScoreTop Affiliating Genes
1polydactyly, preaxial type ii34.0LMBR1, SHH
2hypoplastic or aplastic tibia with polydactyly33.9LMBR1, SHH
3postaxial polydactyly type a, unilateral33.7LMBR1, SHH
4polydactyly, preaxial, type iv33.5GLI2, GLI3, SHH
5preaxial polydactyly of toes, unilateral33.4GLI3, ZNF141
6laurin-sandrow syndrome32.9LMBR1, SHH
7polysyndactyly, bilateral32.0LMBR1, SHH
8pallister-hall syndrome32.0GLI2, GLI3
9imperforate anus30.7GLI2, GLI3, SHH
10syndactyly, type iv30.5LMBR1, SHH
11weyers acrofacial dysostosis29.6DYNC2H1, NEK1, WDR34, WDR35, WDR60
12short-rib thoracic dysplasia 3 with or without polydactyly12.2
13polydactyly, postaxial, types a1 and b12.1
14short-rib thoracic dysplasia 6 with or without polydactyly12.1
15megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome12.0
16polydactyly, preaxial i12.0
17short-rib thoracic dysplasia 7 with or without polydactyly12.0
18short-rib thoracic dysplasia 8 with or without polydactyly12.0
19polydactyly, preaxial iii11.9
20short-rib thoracic dysplasia 10 with or without polydactyly11.9
21megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 111.9
22polydactyly, postaxial, with progressive myopia11.9
23dandy-walker malformation with postaxial polydactyly11.9
24short-rib thoracic dysplasia 11 with or without polydactyly11.9
25megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 211.9
26megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 311.9
27short-rib thoracic dysplasia 14 with polydactyly11.9
28short-rib thoracic dysplasia 4 with or without polydactyly11.9
29short-rib thoracic dysplasia 5 with or without polydactyly11.9
30short-rib thoracic dysplasia 13 with or without polydactyly11.9
31clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly11.9
32central polydactyly of toes11.9
33postaxial polydactyly of toes11.9
34preaxial polydactyly of toes11.9
35central polydactyly of fingers11.9
36polydactyly, postaxial, type a611.9
37short-rib thoracic dysplasia 2 with or without polydactyly11.8
38short-rib thoracic dysplasia 9 with or without polydactyly11.8
39short-rib thoracic dysplasia 1 with or without polydactyly11.8
40polydactyly of a biphalangeal thumb, unilateral11.8
41polydactyly of a biphalangeal thumb, bilateral11.8
42polydactyly of a triphalangeal thumb, unilateral11.8
43polydactyly of a triphalangeal thumb, bilateral11.8
44polydactyly of an index finger, unilateral11.8
45polydactyly of an index finger, bilateral11.8
46central polydactyly of fingers, unilateral11.8
47central polydactyly of fingers, bilateral11.8
48central polydactyly of toes, bilateral11.8
49central polydactyly of toes, unilateral11.8
50split-foot malformation with mesoaxial polydactyly11.8

Graphical network of the top 20 diseases related to Polydactyly:



Diseases related to polydactyly

Symptoms for Polydactyly

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Drugs & Therapeutics for Polydactyly

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Drugs for Polydactyly (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Menthol21842216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
2insulin4401

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phenotype and Etiology of Pallister-Hall SyndromeCompletedNCT00001404
2Triphalangeal Thumbs in the Pediatric Population: Long Term Outcomes Following Surgical InterventionCompletedNCT01409980
3Bardet-Biedl Syndrome Study: Clinical and Genetic Epidemiology Study in AdultsCompletedNCT00213811
4Clinical and Molecular Investigations Into CiliopathiesRecruitingNCT00068224
5Genetics and Clinical Characteristics of Bardet-Biedl SyndromeTerminatedNCT00078091

Search NIH Clinical Center for Polydactyly


Cochrane evidence based reviews: polydactyly

Genetic Tests for Polydactyly

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Genetic tests related to Polydactyly:

id Genetic test Affiliating Genes
1 Postaxial Polydactyly25
2 Polydactyly25

Anatomical Context for Polydactyly

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MalaCards organs/tissues related to Polydactyly:

34
Heart, Kidney, Brain, Bone, Tongue, Skin, Pituitary

Animal Models for Polydactyly or affiliated genes

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MGI Mouse Phenotypes related to Polydactyly:

39 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.4BBS2, BBS4, BBS7, GLI3, SHH
2MP:00053779.3BBS4, GLI2, GLI3, PITX1, SHH
3MP:00053898.3BBS2, BBS4, BBS7, CCND2, GLI2, GLI3
4MP:00053888.1BBS4, DYNC2H1, GLI2, GLI3, IFT172, SHH
5MP:00053798.0BBS2, BBS4, CCND2, GLI2, GLI3, NEK1
6MP:00053677.6BBS2, BBS4, BBS7, DYNC2H1, GLI3, IFT172
7MP:00053827.5BBS4, BBS7, DYNC2H1, GLI2, GLI3, IFT172
8MP:00053807.2BBS4, BBS7, DYNC2H1, GLI2, GLI3, IFT172
9MP:00053857.1BBS4, BBS7, CCND2, DYNC2H1, GLI3, IFT172
10MP:00053917.1BBS2, BBS4, BBS7, CCND2, DYNC2H1, GLI2
11MP:00053907.0DYNC2H1, GLI2, GLI3, IFT172, LMBR1, NEK1
12MP:00053816.8BBS2, BBS4, BBS7, DYNC2H1, GLI2, GLI3
13MP:00036316.4BBS2, BBS4, BBS7, CCND2, DYNC2H1, GLI2
14MP:00053786.3BBS2, BBS4, BBS7, DYNC2H1, GLI2, GLI3
15MP:00053716.3BBS2, BBS7, DYNC2H1, GLI2, GLI3, IFT172
16MP:00107686.2BBS4, BBS7, CCND2, DYNC2H1, GLI2, GLI3

Publications for Polydactyly

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Articles related to Polydactyly:

(show top 50)    (show all 658)
idTitleAuthorsYear
1
The syndrome dysmorphic facies, renal agenesis, ambiguous genitalia, microcephaly, polydactyly and lissencephaly (DREAM-PL): Report of two additional patients. (27480277)
2016
2
A Novel ZRS Mutation in a Chinese Patient with Preaxial Polydactyly and Triphalangeal Thumb. (27592358)
2016
3
Parallel Evolution of Polydactyly Traits in Chinese and European Chickens. (26859147)
2016
4
Polydactyly: A Review. (27194607)
2016
5
Exome sequencing identifies a mutation in OFD1 in a male with Joubert syndrome, orofaciodigital spectrum anomalies and complex polydactyly. (27081566)
2016
6
Intranatal Torsion of Polydactyly: A Rare Event. (26828689)
2016
7
Clinical characterisation of polydactyly in Maine Coon cats. (26862149)
2016
8
A Rare Cause of Persistent Pulmonary Hypertension Resistant to Therapy in The Newborn: Short-Rib Polydactyly Syndrome. (26078906)
2015
9
Autopsy observations in lethal short-rib polydactyly syndromes. (25437139)
2015
10
An unusual case of radial polydactyly, (tetraplication of the thumb, duplication of the radial carpal bones and bifurcation of the radius). (25664282)
2014
11
Deletions in PITX1 cause a spectrum of lower-limb malformations including mirror-image polydactyly. (22258522)
2012
12
A novel mutation in the SHH long-range regulator (ZRS) is associated with preaxial polydactyly, triphalangeal thumb, and severe radial ray deficiency. (22903933)
2012
13
Congenital polydactyly and polymetatarsalia: classification, genetics, and surgical correction. 1981. (21513870)
2011
14
Understanding the molecular basis of polydactyly. (20954615)
2010
15
Two rare cases of association of thumb hypoplasia and polydactyly of the homolateral foot. (19129363)
2009
16
Crossed polydactyly prenatally diagnosed by 2- and 3-dimensional sonography. (17384052)
2007
17
Polydactyly of the foot. (17414786)
2007
18
Hemizygosity for chromosome 2q14.2-q22.1 spanning the GLI2 and PROC genes associated with growth hormone deficiency, polydactyly, deep vein thrombosis and urogenital abnormalities. (16650085)
2006
19
Experience with the surgical treatment of radial polydactyly in adults. (16186699)
2005
20
Exencephaly induction by valproic acid in the genetic polydactyly/arhinencephaly mouse, Pdn/Pdn. (16359493)
2005
21
Apert syndrome with preaxial polydactyly showing the typical mutation Ser252Trp in the FGFR2 gene. (16440883)
2005
22
Megalencephaly and perisylvian polymicrogyria with postaxial polydactyly and hydrocephalus: a rare brain malformation syndrome associated with mental retardation and seizures. (15627943)
2004
23
A female with complete lack of MA1llerian fusion, postaxial polydactyly, and tetralogy of fallot: genetic heterogeneity of McKusick-Kaufman syndrome or a unique syndrome? (15266619)
2004
24
Short rib-polydactyly syndrome type I associated with a single umbilical artery. (15083709)
2004
25
A 34-week-old male fetus with short rib polydactyly syndrome (SRPS) type I (Saldino-Noonan) with pancreatic cysts. (12921311)
2003
26
Diaphragmatic hernia and preaxial polydactyly in spondylothoracic dysplasia. (14564219)
2003
27
Polydactyly: how many disorders and how many genes? (12357471)
2002
28
Liver fibrocystic disease and polydactyly: proposal of a new syndrome. (11343330)
2001
29
Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly. (10952899)
2000
30
Polydactyly reported by Raphael. (11124206)
2000
31
Clinical and genetic studies on 12 preaxial polydactyly families and refinement of the localisation of the gene responsible to a 1.9 cM region on chromosome 7q36. (9950363)
1999
32
A new syndrome: heart defects, laryngeal anomalies, preaxial polydactyly, and colonic aganglionosis in sibs. (11336448)
1999
33
Associated anomalies in individuals with polydactyly. (9880209)
1998
34
Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling. (9671585)
1998
35
Urinary hydrocolpos, cloacal malformation and pre-axial polydactyly: a rare variant of neonatal hydrocolpos. (9565227)
1998
36
A case of familial Bardet-Biedl syndrome (obesity, slight mental retardation, polydactyly, retinitis pigmentosum and renal failure) with insulin-resistant diabetes mellitus]. (10063326)
1998
37
Complete digital duplication: a case report and review of ulnar polydactyly. (9464703)
1998
38
A large family with type IV radial polydactyly. (9726561)
1998
39
The atrioventricular canal defect is the congenital heart disease connecting short rib-polydactyly and oral-facial-digital syndromes. (8986290)
1997
40
Concomitant syndactyly and polydactyly in a pediatric foot. (9127221)
1997
41
Subclassification of polydactyly. (8733358)
1996
42
The zig-zag deformity in pre-axial polydactyly. A new cause and its treatment. (7595006)
1995
43
On congenital obesity syndrome with polydactyly and retinitis pigmentosa (a contribution to the study of clinical forms of hypophyseal obesity). 1920. (8521156)
1995
44
Apert syndrome with partial post-axial polydactyly and unilateral choanal atresia. (7890361)
1994
45
Polydactyly of the thumb. (8436855)
1993
46
Harlequin fetus with polydactyly and renal dysplasia. (2279815)
1990
47
Encephalocele, polycystic kidneys, and polydactyly with other defects. A necropsy case of Meckel syndrome and a review of literature. (3604681)
1987
48
The lethal multiple congenital anomaly syndrome of polydactyly, sex reversal, renal hypoplasia, and unilobular lungs. (3950937)
1986
49
Brachydactyly and polydactyly with dermal ridge dissociation and ridge hypoplasia. (513089)
1979
50
A 63-mm human fetus with radial aplasia, tibial polydactyly, rib and vertebral fusions, and right aortic arch. (4428420)
1974

Variations for Polydactyly

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Copy number variations for Polydactyly from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
197909161470000016700000Duplication or delet ionpolydactyly

Expression for genes affiliated with Polydactyly

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Search GEO for disease gene expression data for Polydactyly.

Pathways for genes affiliated with Polydactyly

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GO Terms for genes affiliated with Polydactyly

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Cellular components related to Polydactyly according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1pericentriolar materialGO:000024210.3BBS4, NEK1
2motile primary ciliumGO:003151210.2DYNC2H1, GLI2
3ciliary baseGO:009754610.1GLI2, GLI3
4BBSomeGO:00344649.9BBS2, BBS4, BBS7
5ciliary membraneGO:00601709.4BBS2, BBS4, BBS7
6ciliary tipGO:00975428.3DYNC2H1, GLI2, GLI3, IFT172, WDR34, WDR35
7primary ciliumGO:00723728.3DYNC2H1, GLI2, GLI3, IFT172, WDR34, WDR35
8ciliary basal bodyGO:00360648.1BBS2, BBS4, BBS7, IFT172, WDR34, WDR35
9ciliumGO:00059298.1BBS4, GLI2, GLI3, IFT172, WDR35, WDR60
10axonemeGO:00059307.7BBS7, DYNC2H1, GLI2, GLI3, IFT172, WDR34

Biological processes related to Polydactyly according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of alpha-beta T cell differentiationGO:004663910.7GLI3, SHH
2positive regulation of alpha-beta T cell differentiationGO:004663810.6GLI3, SHH
3artery developmentGO:006084010.6GLI3, SHH
4tube developmentGO:003529510.6GLI2, GLI3
5embryonic morphogenesisGO:004859810.6GLI3, SHH
6smoothened signaling pathway involved in ventral spinal cord interneuron specificationGO:002177510.6GLI2, GLI3
7smoothened signaling pathway involved in spinal cord motor neuron cell fate specificationGO:002177610.6GLI2, GLI3
8smoothened signaling pathway involved in dorsal/ventral neural tube patterningGO:006083110.5GLI2, GLI3
9smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationGO:002193810.5GLI2, SHH
10ventral midline developmentGO:000741810.5GLI2, SHH
11positive regulation of T cell differentiation in thymusGO:003308910.5GLI2, SHH
12intraciliary retrograde transportGO:003572110.4DYNC2H1, WDR35
13dorsal/ventral neural tube patterningGO:002190410.4GLI2, SHH
14negative regulation of appetite by leptin-mediated signaling pathwayGO:003810810.4BBS2, BBS4
15leptin-mediated signaling pathwayGO:003321010.4BBS2, BBS4
16negative thymic T cell selectionGO:004506010.4GLI3, SHH
17response to leptinGO:004432110.4BBS2, BBS4
18regulation of cilium beat frequency involved in ciliary motilityGO:006029610.4BBS2, BBS4
19protein localization to organelleGO:003336510.3BBS2, BBS4
20spinal cord dorsal/ventral patterningGO:002151310.3GLI2, GLI3, SHH
21hindgut morphogenesisGO:000744210.3GLI2, GLI3, SHH
22anatomical structure developmentGO:004885610.3GLI2, GLI3, SHH
23branching morphogenesis of an epithelial tubeGO:004875410.2GLI2, GLI3, SHH
24anterior/posterior pattern specificationGO:000995210.1GLI2, GLI3, SHH
25developmental growthGO:004858910.1GLI2, GLI3, SHH
26embryonic limb morphogenesisGO:003032610.1DYNC2H1, GLI3, SHH
27odontogenesis of dentin-containing toothGO:004247510.0GLI2, GLI3, SHH
28pattern specification processGO:000738910.0GLI2, GLI3, SHH
29fat cell differentiationGO:00454449.9BBS2, BBS4, BBS7
30anatomical structure formation involved in morphogenesisGO:00486469.9GLI2, GLI3, SHH
31melanosome transportGO:00324029.9BBS2, BBS4, BBS7
32embryonic digit morphogenesisGO:00427339.9GLI2, GLI3, LMBR1, SHH
33striatum developmentGO:00217569.8BBS2, BBS4
34hippocampus developmentGO:00217669.8BBS2, BBS4, GLI3
35nonmotile primary cilium assemblyGO:00350589.8BBS2, BBS4, BBS7
36protein processingGO:00164859.7DYNC2H1, GLI3, IFT172
37positive regulation of smoothened signaling pathwayGO:00458809.6DYNC2H1, IFT172, SHH
38neural tube developmentGO:00219159.5GLI2, GLI3, IFT172
39forebrain developmentGO:00309009.5DYNC2H1, GLI3, SHH
40protein localizationGO:00081049.3BBS2, BBS4, BBS7
41limb developmentGO:00601739.3BBS7, GLI3, IFT172, SHH
42spinal cord motor neuron differentiationGO:00215229.2DYNC2H1, GLI2, GLI3, IFT172, SHH
43heart loopingGO:00019479.1BBS4, BBS7, IFT172, SHH
44palate developmentGO:00600219.1BBS7, GLI3, IFT172, SHH
45determination of left/right symmetryGO:00073688.9BBS7, DYNC2H1, IFT172, SHH
46smoothened signaling pathwayGO:00072248.7BBS7, GLI2, GLI3, IFT172, SHH
47cilium morphogenesisGO:00602718.7BBS2, BBS4, BBS7, DYNC2H1, IFT172
48dorsal/ventral pattern formationGO:00099538.6DYNC2H1, GLI2, GLI3, IFT172, SHH
49heart developmentGO:00075078.3BBS7, DYNC2H1, GLI2, GLI3, IFT172, SHH
50cilium assemblyGO:00423848.0BBS2, BBS4, BBS7, DYNC2H1, IFT172, NEK1

Molecular functions related to Polydactyly according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II repressing transcription factor bindingGO:00011039.4BBS2, BBS4, BBS7
2RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009788.7GLI2, GLI3, PITX1, ZNF141

Sources for Polydactyly

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet