MCID: PLY006
MIFTS: 55

Polydactyly malady

Categories: Rare diseases, Bone diseases, Fetal diseases

Aliases & Classifications for Polydactyly

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Aliases & Descriptions for Polydactyly:

Name: Polydactyly 11 48 27 50 39 13
Polydactyly, Postaxial 50 39 68
Postaxial Polydactyly 11 27
Supernumerary Digits 48
Supernumerary Digit 11
 
Polydactylism 48
Polydactylia 48
Extra Digits 48
Hyperdactyly 48

Classifications:



External Ids:

Disease Ontology11 DOID:1148
ICD1030 Q69, Q69.9
ICD9CM32 755.0, 755.00
NCIt45 C87110

Summaries for Polydactyly

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NIH Rare Diseases:48 Polydactyly is a condition in which a person has more than five fingers per hand or five toes per foot. It is the most common birth defect of the hand and foot. Polydactyly can occur as an isolated finding such that the person has no other physical anomalies or intellectual impairment. However, it can occur in association with other birth defects and cognitive abnormalities as part of a genetic syndrome. In some cases, the extra digits may be well-formed and functional. Surgery may be considered especially for poorly formed digits or very large extra digits. Surgical management depends greatly on the complexity of the deformity. Last updated: 5/8/2015

MalaCards based summary: Polydactyly, also known as polydactyly, postaxial, is related to polydactyly, preaxial type ii and hypoplastic or aplastic tibia with polydactyly. An important gene associated with Polydactyly is GLI3 (GLI Family Zinc Finger 3), and among its related pathways are Hedgehog Pathway and Intraflagellar transport. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are hearing/vestibular/ear and embryo.

Wikipedia:71 Polydactyly or polydactylism (from Greek πολύς (polys), meaning \"many\", and δάκτυλος... more...

Related Diseases for Polydactyly

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Diseases in the Polydactyly family:

Central Polydactyly of Toes

Diseases related to Polydactyly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1polydactyly, preaxial type ii33.8LMBR1, SHH
2hypoplastic or aplastic tibia with polydactyly33.7LMBR1, SHH
3postaxial polydactyly type a, unilateral33.4LMBR1, SHH
4laurin-sandrow syndrome32.6LMBR1, SHH
5polydactyly, preaxial, type iv32.5GLI2, GLI3, MKKS, SHH
6pallister-hall syndrome32.3GLI2, GLI3
7polysyndactyly, bilateral31.7LMBR1, SHH
8syndactyly, type iv31.7LMBR1, SHH
9bardet-biedl syndrome 331.0BBS1, BBS2
10imperforate anus30.5GLI2, GLI3, SHH
11weyers acrofacial dysostosis30.2DYNC2H1, EVC, NEK1, WDR34, WDR35, WDR60
12obesity27.1BBS1, BBS2, BBS4, BBS7, MKKS, TTC8
13short-rib thoracic dysplasia 3 with or without polydactyly12.3
14polydactyly, postaxial, types a1 and b12.2
15short-rib thoracic dysplasia 6 with or without polydactyly12.1
16short-rib thoracic dysplasia 7 with or without polydactyly12.0
17short-rib thoracic dysplasia 8 with or without polydactyly12.0
18short-rib thoracic dysplasia 10 with or without polydactyly12.0
19short-rib thoracic dysplasia 11 with or without polydactyly12.0
20short-rib thoracic dysplasia 14 with polydactyly12.0
21megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 112.0
22short-rib thoracic dysplasia 4 with or without polydactyly12.0
23short-rib thoracic dysplasia 5 with or without polydactyly12.0
24short-rib thoracic dysplasia 2 with or without polydactyly11.9
25short-rib thoracic dysplasia 9 with or without polydactyly11.9
26short-rib thoracic dysplasia 1 with or without polydactyly11.9
27megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 211.9
28megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 311.9
29polydactyly, postaxial, with progressive myopia11.9
30short-rib thoracic dysplasia 13 with or without polydactyly11.9
31clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly11.9
32polydactyly, postaxial, type a611.9
33polydactyly, preaxial i11.8
34split-foot malformation with mesoaxial polydactyly11.8
35polydactyly, preaxial iii11.8
36dandy-walker malformation with postaxial polydactyly11.8
37chondrodysplasia situs inversus imperforate anus polydactyly11.8
38central polydactyly of toes11.7
39postaxial polydactyly of toes11.7
40preaxial polydactyly of toes11.7
41central polydactyly of fingers11.7
42polydactyly of a biphalangeal thumb, unilateral11.7
43polydactyly of a biphalangeal thumb, bilateral11.7
44polydactyly of a triphalangeal thumb, unilateral11.7
45polydactyly of a triphalangeal thumb, bilateral11.7
46polydactyly of an index finger, unilateral11.7
47polydactyly of an index finger, bilateral11.7
48central polydactyly of fingers, unilateral11.7
49central polydactyly of fingers, bilateral11.7
50central polydactyly of toes, bilateral11.7

Graphical network of the top 20 diseases related to Polydactyly:



Diseases related to polydactyly

Symptoms & Phenotypes for Polydactyly

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MGI Mouse Phenotypes related to Polydactyly according to GeneCards Suite gene sharing:

41 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.2BBS1, BBS4, GLI2, GLI3, MKKS, SHH
2MP:00053808.4BBS4, BBS7, DYNC2H1, GLI2, GLI3, SHH
3MP:00053908.3DYNC2H1, EVC, GLI2, GLI3, LMBR1, NEK1
4MP:00053818.2BBS2, BBS4, BBS7, DYNC2H1, GLI2, GLI3
5MP:00053948.2BBS1, BBS2, BBS4, BBS7, GLI3, MKKS
6MP:00053858.0BBS1, BBS4, BBS7, CCND2, DYNC2H1, GLI3
7MP:00053887.9BBS1, BBS4, DYNC2H1, GLI2, GLI3, MKKS
8MP:00053677.9BBS1, BBS2, BBS4, BBS7, DYNC2H1, GLI3
9MP:00053717.1BBS1, BBS2, BBS7, DYNC2H1, EVC, GLI2
10MP:00053896.9BBS1, BBS2, BBS4, BBS7, CCND2, EVC
11MP:00053826.9BBS1, BBS4, BBS7, DYNC2H1, EVC, GLI2
12MP:00053766.8BBS1, BBS2, BBS4, BBS7, CCND2, GLI2
13MP:00053846.6BBS1, BBS2, BBS4, BBS7, DYNC2H1, EVC
14MP:00053786.4BBS1, BBS2, BBS4, BBS7, DYNC2H1, EVC
15MP:00036316.4BBS1, BBS2, BBS4, BBS7, CCND2, DYNC2H1
16MP:00053916.1BBS1, BBS2, BBS4, BBS7, CCND2, DYNC2H1
17MP:00107685.7BBS1, BBS4, BBS7, CCND2, DYNC2H1, EVC

Drugs & Therapeutics for Polydactyly

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Drugs for Polydactyly (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Mentholapproved23532216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
2Liver Extracts3868
3Insulin, Globin Zinc4523
4insulin4524

Interventional clinical trials:

idNameStatusNCT IDPhase
1Triphalangeal Thumbs in the Pediatric Population: Long Term Outcomes Following Surgical InterventionCompletedNCT01409980
2Phenotype and Etiology of Pallister-Hall SyndromeCompletedNCT00001404
3Bardet-Biedl Syndrome Study: Clinical and Genetic Epidemiology Study in AdultsCompletedNCT00213811
4Clinical and Molecular Investigations Into CiliopathiesActive, not recruitingNCT00068224
5Genetics and Clinical Characteristics of Bardet-Biedl SyndromeTerminatedNCT00078091

Search NIH Clinical Center for Polydactyly


Cochrane evidence based reviews: polydactyly

Genetic Tests for Polydactyly

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Genetic tests related to Polydactyly:

id Genetic test Affiliating Genes
1 Postaxial Polydactyly27
2 Polydactyly27

Anatomical Context for Polydactyly

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MalaCards organs/tissues related to Polydactyly:

36
Heart, Kidney, Liver, Tongue, Bone, Brain, Skin

Publications for Polydactyly

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Articles related to Polydactyly:

(show top 50)    (show all 668)
idTitleAuthorsYear
1
Reply: Office-Based Postaxial Polydactyly Excision in Neonates, Infants, and Children. (28027268)
2017
2
Jejunal atresia and unilateral postaxial polydactyly: second report of a rare association. (28059850)
2017
3
Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome. (27666822)
2016
4
The syndrome dysmorphic facies, renal agenesis, ambiguous genitalia, microcephaly, polydactyly and lissencephaly (DREAM-PL): Report of two additional patients. (27480277)
2016
5
A Novel ZRS Mutation in a Chinese Patient with Preaxial Polydactyly and Triphalangeal Thumb. (27592358)
2016
6
Parallel Evolution of Polydactyly Traits in Chinese and European Chickens. (26859147)
2016
7
Polydactyly: A Review. (27194607)
2016
8
Exome sequencing identifies a mutation in OFD1 in a male with Joubert syndrome, orofaciodigital spectrum anomalies and complex polydactyly. (27081566)
2016
9
Intranatal Torsion of Polydactyly: A Rare Event. (26828689)
2016
10
Clinical characterisation of polydactyly in Maine Coon cats. (26862149)
2016
11
The Rotterdam Foot Classification: A Classification System for Medial Polydactyly of the Foot. (27489321)
2016
12
Exome sequencing reveals a novel nonsense mutation of GLI3 in a Chinese family with 'non-syndromic' pre-axial polydactyly. (27305983)
2016
13
Office-Based Post-Axial Polydactyly Excision in Neonates, Infants and Children. (27643414)
2016
14
Mechanism of pancreatic and liver malformations in human fetuses with short-rib polydactyly syndrome. (26970085)
2016
15
Identification of novel DYNC2H1 mutations associated with short rib-polydactyly syndrome type III using next-generation panel sequencing. (27323140)
2016
16
Office-Based Post-Axial Polydactyly Excision in Neonates, Infants, and Children. (26818291)
2016
17
Clinical study of 459 polydactyly cases in China, 2010 to 2014. (26953323)
2016
18
A novel H395R mutation in MKKS/BBS6 causes retinitis pigmentosa and polydactyly without other findings of Bardet-Biedl or McKusick-Kaufman syndrome. (26900326)
2016
19
Fanconi Anemia Concurrent with an Unusual Thumb Polydactyly: A Case Report. (27200401)
2016
20
An increased duplication of ZRS region that caused more than one supernumerary digits preaxial polydactyly in a large Chinese family. (27922091)
2016
21
Mutations in DYNC2H1, the cytoplasmic dynein 2, heavy chain 1 motor protein gene, cause short-rib polydactyly type I, Saldino-Noonan type. (27925158)
2016
22
Decision-making and Management of Ulnar Polydactyly of the Newborn: Outcomes and Satisfaction. (27595947)
2016
23
Classifications in Brief: The Wassel Classification for Radial Polydactyly. (27613532)
2016
24
Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. (27801979)
2016
25
Polydactyly and obesity - the clinical manifestation of ciliopathy: a boy with Bardet-Biedl syndrome. (27442694)
2016
26
Clinical Presentation, Surgical Treatment, and Outcome in Radial Polydactyly. (26895514)
2016
27
Two cases of polydactyly in wild brown howler monkeys (Alouatta guariba clamitans). (26689726)
2016
28
An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome. (27466187)
2016
29
IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome. (27466190)
2016
30
Rare case of tibial hemimelia, preaxial polydactyly, and club foot. (28035313)
2016
31
Inactivation of Sonic Hedgehog Signaling and Polydactyly in Limbs of Hereditary Multiple Malformation, a Novel Type of Talpid Mutant. (28083533)
2016
32
Novel frameshift mutation in the CHD7 gene associated with CHARGE syndrome with preaxial polydactyly. (26901670)
2016
33
Postoperative Growth in Radial Polydactyly: A Clinical Study. (27475961)
2016
34
An unusual presentation of postaxial polydactyly of the foot. (27910230)
2016
35
Retraction notice to "The identification of loci for polydactyly in chickens using a genome-wide association study" [GENE 568/2 (2015) 176-180]. (27049671)
2016
36
Reply to correspondence: Office-Based Post-Axial Polydactyly Excision in Neonates, Infants, and Children. (27643419)
2016
37
Prenatal Diagnosis of Short Rib-Polydactyly Type II by Ultrasound in Three Consecutive Pregnancies. (27803525)
2016
38
A Matched Comparative Study of the Bilhaut Procedure Versus Resection and Reconstruction for Treatment of Radial Polydactyly Types II and IV. (26880498)
2016
39
A Rare Cause of Persistent Pulmonary Hypertension Resistant to Therapy in The Newborn: Short-Rib Polydactyly Syndrome. (26078906)
2015
40
Autopsy observations in lethal short-rib polydactyly syndromes. (25437139)
2015
41
An additional clinical sign of 17q21.31 microdeletion syndrome: Preaxial polydactyly of hands with broad thumbs. (25858762)
2015
42
GLI2 mutations typically result in pituitary anomalies with or without postaxial polydactyly. (25974718)
2015
43
Coexistence of left internal carotid agenesis, klippel-feil syndrome and postaxial polydactyly. (25806098)
2015
44
Letter to the editor regarding: "Novel frame-shift mutations of GLI3 gene in non-syndromic postaxial polydactyly patients" Clinica Chimica acta 433 (2014) 195-199. (25869409)
2015
45
Teaching NeuroImages: Short stature, imperforate anus, and polydactyly: When is a hypothalamic mass an incidentaloma? (25870458)
2015
46
Review of literature: genes related to postaxial polydactyly. (25717468)
2015
47
Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome. (26077881)
2015
48
GLI3 mutations in syndromic and non-syndromic polydactyly in two Indian families. (26508445)
2015
49
Radial Polydactyly and the Incidence of Reoperation Using A New Classification System. (25633612)
2015
50
Collodion baby with polydactyly. (25657923)
2015

Variations for Polydactyly

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Copy number variations for Polydactyly from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
197909161470000016700000Duplication or delet ionpolydactyly

Expression for genes affiliated with Polydactyly

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Search GEO for disease gene expression data for Polydactyly.

Pathways for genes affiliated with Polydactyly

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GO Terms for genes affiliated with Polydactyly

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Cellular components related to Polydactyly according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1ciliary baseGO:009754610.4GLI2, GLI3
2motile ciliumGO:00315149.9BBS2, BBS4, MKKS
3pericentriolar materialGO:00002429.7BBS4, NEK1
4ciliary tipGO:00975429.1DYNC2H1, GLI2, GLI3, WDR34, WDR35, WDR60
5BBSomeGO:00344649.1BBS1, BBS2, BBS4, BBS7, TTC8
6ciliary membraneGO:00601708.7BBS1, BBS2, BBS4, BBS7, EVC, TTC8
7ciliumGO:00059298.5BBS4, EVC, GLI2, GLI3, TTC8, WDR35
8axonemeGO:00059308.2BBS1, BBS7, DYNC2H1, GLI2, GLI3, WDR34
9centrosomeGO:00058137.9BBS1, BBS4, BBS7, MKKS, NEK1, TTC8
10ciliary basal bodyGO:00360647.5BBS1, BBS2, BBS4, BBS7, EVC, MKKS
11cytosolGO:00058296.8BBS1, BBS2, BBS4, BBS7, CCND2, DYNC2H1

Biological processes related to Polydactyly according to GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idNameGO IDScoreTop Affiliating Genes
1artery developmentGO:006084010.8GLI3, SHH
2embryonic digestive tract morphogenesisGO:004855710.8GLI3, SHH
3embryonic morphogenesisGO:004859810.8GLI3, SHH
4negative regulation of alpha-beta T cell differentiationGO:004663910.7GLI3, SHH
5negative thymic T cell selectionGO:004506010.7GLI3, SHH
6positive regulation of alpha-beta T cell differentiationGO:004663810.7GLI3, SHH
7positive regulation of neuroblast proliferationGO:000205210.7GLI3, SHH
8positive regulation of protein import into nucleusGO:004230710.7GLI3, SHH
9protein localization to organelleGO:003336510.6BBS2, BBS4
10artery smooth muscle contractionGO:001482410.6BBS2, MKKS
11embryonic limb morphogenesisGO:003032610.5DYNC2H1, GLI3, SHH
12face developmentGO:006032410.5BBS4, MKKS
13forebrain developmentGO:003090010.5DYNC2H1, GLI3, SHH
14negative regulation of actin filament polymerizationGO:003083710.5BBS4, MKKS
15intraciliary retrograde transportGO:003572110.4DYNC2H1, WDR35
16vasodilationGO:004231110.4BBS2, MKKS
17embryonic digestive tract developmentGO:004856610.4GLI2, GLI3
18sensory processingGO:005089310.4BBS4, TTC8
19dorsal/ventral neural tube patterningGO:002190410.4GLI2, SHH
20hindbrain developmentGO:003090210.3GLI2, SHH
21positive regulation of smoothened signaling pathwayGO:004588010.3DYNC2H1, EVC, SHH
22brain morphogenesisGO:004885410.3BBS2, BBS4, MKKS
23cerebral cortex developmentGO:002198710.3BBS2, BBS4, MKKS
24osteoblast developmentGO:000207610.3GLI2, SHH
25proximal/distal pattern formationGO:000995410.3GLI2, GLI3
26positive regulation of T cell differentiation in thymusGO:003308910.3GLI2, SHH
27smoothened signaling pathway involved in dorsal/ventral neural tube patterningGO:006083110.3GLI2, GLI3
28leptin-mediated signaling pathwayGO:003321010.3BBS2, BBS4, MKKS
29smoothened signaling pathway involved in spinal cord motor neuron cell fate specificationGO:002177610.3GLI2, GLI3
30smoothened signaling pathway involved in ventral spinal cord interneuron specificationGO:002177510.3GLI2, GLI3
31negative regulation of appetite by leptin-mediated signaling pathwayGO:003810810.3BBS2, BBS4, MKKS
32tube developmentGO:003529510.2GLI2, GLI3
33cartilage developmentGO:005121610.2BBS2, EVC, MKKS
34smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationGO:002193810.2GLI2, SHH
35positive regulation of multicellular organism growthGO:004001810.2BBS2, BBS4, MKKS
36ventral midline developmentGO:000741810.2GLI2, SHH
37regulation of cilium beat frequency involved in ciliary motilityGO:006029610.2BBS2, BBS4, MKKS
38anatomical structure developmentGO:004885610.2GLI2, GLI3, SHH
39response to leptinGO:004432110.2BBS2, BBS4, MKKS
40anatomical structure formation involved in morphogenesisGO:004864610.2GLI2, GLI3, SHH
41anterior/posterior pattern specificationGO:000995210.2GLI2, GLI3, SHH
42branching morphogenesis of an epithelial tubeGO:004875410.2GLI2, GLI3, SHH
43digestive tract morphogenesisGO:004854610.2BBS7, SHH
44developmental growthGO:004858910.2GLI2, GLI3, SHH
45striatum developmentGO:002175610.1BBS2, BBS4, MKKS
46hindgut morphogenesisGO:000744210.1GLI2, GLI3, SHH
47kidney developmentGO:000182210.1GLI2, GLI3, SHH
48lung developmentGO:003032410.1GLI2, GLI3, SHH
49odontogenesis of dentin-containing toothGO:004247510.1GLI2, GLI3, SHH
50pattern specification processGO:000738910.1GLI2, GLI3, SHH

Molecular functions related to Polydactyly according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1patched bindingGO:000511310.3BBS1, SHH
2RNA polymerase II repressing transcription factor bindingGO:00011037.9BBS1, BBS2, BBS4, BBS7, MKKS, TTC8

Sources for Polydactyly

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2CDC
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10DGIdb
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16FDA
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