Aliases & Classifications for Polydactyly

MalaCards integrated aliases for Polydactyly:

Name: Polydactyly 53 12 72 49 28 51 41 14
Polydactyly, Postaxial 41 69
Non-Syndromic Polydactyly 49
Postaxial Polydactyly 12
Polydactyly Postaxial 72
Supernumerary Digits 49
Supernumerary Digit 12
Polydactylism 49
Extra Digits 49
Hyperdactyly 49
Polydactylia 49

Classifications:



External Ids:

OMIM 53 603596
Disease Ontology 12 DOID:1148
ICD10 32 Q69 Q69.9
ICD9CM 34 755.0 755.00
NCIt 46 C87110
MedGen 39 C0152427

Summaries for Polydactyly

NIH Rare Diseases : 49 Polydactyly is a condition in which a person has more than five fingers per hand or five toes per foot. It is the most common birth defect of the hand and foot. Polydactyly can occur as an isolated finding such that the person has no other physical anomalies or intellectual impairment. However, it can occur in association with other birth defects and cognitive abnormalities as part of a genetic syndrome. In some cases, the extra digits may be well-formed and functional. Surgery may be considered especially for poorly formed digits or very large extra digits. Surgical management depends greatly on the complexity of the deformity. Last updated: 5/8/2015

MalaCards based summary : Polydactyly, also known as polydactyly, postaxial, is related to polydactyly, preaxial ii and tibia, hypoplasia or aplasia of, with polydactyly. An important gene associated with Polydactyly is MKS1 (Meckel Syndrome, Type 1), and among its related pathways/superpathways are Signaling by Hedgehog and Organelle biogenesis and maintenance. The drugs Menthol and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related phenotypes are cellular and growth/size/body region

Wikipedia : 72 Polydactyly or polydactylism (from Greek πολύς (polys), meaning \'many\', and δάκτυλος (daktylos),... more...

Description from OMIM: 603596

Related Diseases for Polydactyly

Diseases in the Polydactyly family:

Central Polydactyly of Toes

Diseases related to Polydactyly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 434)
# Related Disease Score Top Affiliating Genes
1 polydactyly, preaxial ii 34.0 LMBR1 SHH
2 tibia, hypoplasia or aplasia of, with polydactyly 33.9 LMBR1 SHH
3 polydactyly of a triphalangeal thumb, unilateral 33.5 LMBR1 SHH
4 polydactyly of a triphalangeal thumb, bilateral 33.5 LMBR1 SHH
5 short-rib thoracic dysplasia 3 with or without polydactyly 33.4 DYNC2H1 NEK1 WDR34 WDR35 WDR60
6 postaxial polydactyly type a, bilateral 33.3 GLI3 ZNF141
7 short-rib thoracic dysplasia 1 with or without polydactyly 33.0 DYNC2H1 DYNC2LI1 WDR34 WDR35 WDR60
8 laurin-sandrow syndrome 32.7 LMBR1 MIPOL1 SHH
9 pallister-hall syndrome 32.4 GLI2 GLI3 MKKS SHH
10 syndactyly, type iv 31.5 LMBR1 SHH
11 ellis-van creveld syndrome 31.5 DYNC2H1 DYNC2LI1 NEK1 WDR34 WDR35 WDR60
12 basal cell nevus syndrome 31.2 GLI2 GLI3 SHH
13 bardet-biedl syndrome 4 31.0 BBS1 BBS2 BBS4
14 mckusick-kaufman syndrome 31.0 BBS1 BBS2 BBS4 BBS7 GLI3 MKKS
15 hydrolethalus syndrome 1 30.9 BBS2 BBS4 MKS1 SHH
16 bardet-biedl syndrome 3 30.9 BBS1 BBS2 BBS4
17 asphyxiating thoracic dystrophy 30.5 BBS1 BBS7 DYNC2H1 DYNC2LI1 NEK1 WDR34
18 bardet-biedl syndrome 15 30.5 BBS2 BBS4 MKKS
19 bardet-biedl syndrome 8 30.4 BBS1 BBS2 BBS4 BBS7
20 bardet-biedl syndrome 17 30.3 BBS1 BBS2 BBS4 BBS7 GLI2 SHH
21 bardet-biedl syndrome 10 30.3 BBS1 BBS2 BBS4 BBS7 MKKS
22 bardet-biedl syndrome 12 30.3 BBS1 BBS2 BBS4 BBS7 MKKS
23 bardet-biedl syndrome 2 30.2 BBS1 BBS2 BBS4 BBS7 MKKS
24 bardet-biedl syndrome 18 30.1 BBS1 BBS2 BBS4 BBS7
25 bardet-biedl syndrome 13 30.0 BBS1 BBS2 BBS4 MKS1
26 holoprosencephaly 29.9 GLI2 GLI3 SHH
27 alobar holoprosencephaly 29.8 GLI2 SHH
28 bardet-biedl syndrome 1 29.8 BBS1 BBS2 BBS4 BBS7 MKKS
29 bardet-biedl syndrome 6 29.7 BBS1 BBS2 BBS4 BBS7 MKKS
30 bardet-biedl syndrome 11 29.4 BBS1 BBS2 BBS4 BBS7 MKKS MKS1
31 bardet-biedl syndrome 29.1 BBS1 BBS2 BBS4 BBS7 MKKS MKS1
32 ciliopathy 28.5 BBS1 BBS7 MKS1 WDR35
33 tetralogy of fallot 27.8 BBS1 BBS2 BBS4 BBS7 MKKS
34 polydactyly, postaxial, type a1 12.4
35 short-rib thoracic dysplasia 6 with or without polydactyly 12.4
36 polydactyly, preaxial i 12.3
37 megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 12.3
38 short-rib thoracic dysplasia 10 with or without polydactyly 12.2
39 polydactyly, preaxial iv 12.2
40 dandy-walker malformation with postaxial polydactyly 12.2
41 short-rib thoracic dysplasia 4 with or without polydactyly 12.2
42 short-rib thoracic dysplasia 5 with or without polydactyly 12.2
43 preaxial deficiency, postaxial polydactyly, and hypospadias 12.1
44 short-rib thoracic dysplasia 2 with or without polydactyly 12.1
45 short-rib thoracic dysplasia 7 with or without polydactyly 12.1
46 polydactyly, preaxial iii 12.1
47 short-rib thoracic dysplasia 8 with or without polydactyly 12.1
48 tibia absent polydactyly arachnoid cyst 12.1
49 short-rib thoracic dysplasia 11 with or without polydactyly 12.1
50 short-rib thoracic dysplasia 14 with polydactyly 12.1

Graphical network of the top 20 diseases related to Polydactyly:



Diseases related to Polydactyly

Symptoms & Phenotypes for Polydactyly

Clinical features from OMIM:

603596

MGI Mouse Phenotypes related to Polydactyly:

43 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.34 BBS1 BBS2 BBS4 BBS7 DYNC2H1 DYNC2LI1
2 growth/size/body region MP:0005378 10.32 LMBR1 MKKS MKS1 NEK1 SHH BBS1
3 cardiovascular system MP:0005385 10.31 BBS1 BBS4 BBS7 CCND2 DYNC2H1 DYNC2LI1
4 homeostasis/metabolism MP:0005376 10.29 BBS1 BBS2 BBS4 BBS7 CCND2 DYNC2LI1
5 mortality/aging MP:0010768 10.28 DYNC2LI1 GLI2 GLI3 LMBR1 MKKS MKS1
6 craniofacial MP:0005382 10.25 BBS1 BBS4 BBS7 DYNC2H1 GLI2 GLI3
7 nervous system MP:0003631 10.25 SHH BBS1 BBS2 BBS4 BBS7 CCND2
8 limbs/digits/tail MP:0005371 10.23 BBS1 BBS2 BBS7 DYNC2H1 DYNC2LI1 GLI2
9 digestive/alimentary MP:0005381 10.19 BBS2 BBS4 BBS7 DYNC2H1 GLI2 GLI3
10 embryo MP:0005380 10.18 GLI2 GLI3 MKS1 SHH WDR35 BBS4
11 reproductive system MP:0005389 10.06 BBS1 BBS2 BBS4 BBS7 CCND2 GLI2
12 hearing/vestibular/ear MP:0005377 10.04 BBS1 BBS4 GLI2 GLI3 MKKS MKS1
13 renal/urinary system MP:0005367 10.02 BBS7 DYNC2H1 GLI3 MKS1 NEK1 SHH
14 respiratory system MP:0005388 9.91 BBS1 BBS4 DYNC2H1 GLI2 GLI3 MKKS
15 skeleton MP:0005390 9.76 DYNC2H1 GLI2 GLI3 LMBR1 MKS1 NEK1
16 taste/olfaction MP:0005394 9.5 BBS1 BBS2 BBS4 BBS7 GLI3 MKKS
17 vision/eye MP:0005391 9.4 GLI3 MIPOL1 MKKS MKS1 SHH BBS1

Drugs & Therapeutics for Polydactyly

Drugs for Polydactyly (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved 2216-51-5 16666
2 Liver Extracts
3 insulin
4 Insulin, Globin Zinc

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Triphalangeal Thumbs in the Pediatric Population: Long Term Outcomes Following Surgical Intervention Completed NCT01409980
2 Phenotype and Etiology of Pallister-Hall Syndrome Completed NCT00001404
3 Bardet-Biedl Syndrome Study: Clinical and Genetic Epidemiology Study in Adults Completed NCT00213811
4 Clinical and Molecular Investigations Into Ciliopathies Active, not recruiting NCT00068224
5 Visualize Nociceptor Changes in Neuropathic Human Not yet recruiting NCT03112057
6 Genetics and Clinical Characteristics of Bardet-Biedl Syndrome Terminated NCT00078091

Search NIH Clinical Center for Polydactyly

Cochrane evidence based reviews: polydactyly

Genetic Tests for Polydactyly

Genetic tests related to Polydactyly:

# Genetic test Affiliating Genes
1 Polydactyly 28

Anatomical Context for Polydactyly

MalaCards organs/tissues related to Polydactyly:

38
Heart, Kidney, Liver, Brain, Bone, Tongue, Skin

Publications for Polydactyly

Articles related to Polydactyly:

(show top 50) (show all 708)
# Title Authors Year
1
Polydactyly of the Hand. ( 29309292 )
2018
2
Identity-by-descent refines mapping of candidate regions for preaxial polydactyly II /III in a large Chinese pedigree. ( 28690477 )
2018
3
Whole exome sequencing reveals a mutation in ARMC9 as a cause of mental retardation, ptosis, and polydactyly. ( 29159890 )
2018
4
The association between preaxial polydactyly and radial longitudinal deficiency in syndromic cases: a report on nine families. ( 29451098 )
2018
5
Polydactyly, postaxial, type B. ( 29377639 )
2018
6
Radial Polydactyly. What's New?. ( 29366421 )
2018
7
Thenar Dysplasia in Radial Polydactyly Depends on the Level of Bifurcation. ( 29280874 )
2018
8
An On-Top-Plasty Reconstruction for Complicated Radial Polydactyly. ( 29313380 )
2018
9
Expanding the phenotype associated with biallelic WDR60 mutations: Siblings with retinal degeneration and polydactyly lacking other features of short rib thoracic dystrophies. ( 29271569 )
2018
10
Reply: Office-Based Postaxial Polydactyly Excision in Neonates, Infants, and Children. ( 28027268 )
2017
11
Complex postaxial polydactyly types A and B with camptodactyly, hypoplastic third toe, zygodactyly and other digit anomalies caused by a novel GLI3 mutation. ( 28315472 )
2017
12
Preaxial polydactyly of the foot. ( 28946786 )
2017
13
Oblique osteotomy for the correction of the zigzag deformity of Wassel type IV polydactyly. ( 28820841 )
2017
14
Girl with polydactyly and pigmentary retinopathy. ( 28370861 )
2017
15
Management of Postaxial Polydactyly in the Neonatal Unit. ( 29084325 )
2017
16
Genetic Overview of Syndactyly and Polydactyly. ( 29263957 )
2017
17
Firm Elevation of Reconstructed Auricle Using Polydactyly Digit in Microtia. ( 29135725 )
2017
18
Genetic pattern and gene localization of polydactyly in Beijing fatty chicken. ( 28489934 )
2017
19
Reconstruction of Wassel Type VI Radial Polydactyly with Triphalangeal Thumb Using an On-top Osteotomy. ( 28280661 )
2017
20
Self-Amputation of the Extra Digit in a Fetus with Polydactyly: First Ultrasound Demonstration. ( 28391260 )
2017
21
Association of SNP rs80659072 in the ZRS with polydactyly in Beijing You chickens. ( 29016641 )
2017
22
Jejunal atresia and unilateral postaxial polydactyly: second report of a rare association. ( 28059850 )
2017
23
Identification of a c.544C>T mutation in WDR34 as a deleterious recessive allele of short rib-polydactyly syndrome. ( 29241935 )
2017
24
Mutations in IFT-A satellite core component genes IFT43 and IFT121 produce short rib polydactyly syndrome with distinctive campomelia. ( 28400947 )
2017
25
Treatment of postaxial polydactyly with plantar plate and medial collateral ligament reconstruction after supernumerary excision: A case report. ( 29085641 )
2017
26
Polydactyly suggesting local husbandry of Pre-Columbian camelids: A case from Castillo de Huarmey archaeological site, northern coast of Peru. ( 28290309 )
2017
27
Recurrent Urinary Tract Infections in a Female Child With Polydactyly and a Pelvic Mass: Consider the McKusick-Kaufman Syndrome. ( 28153592 )
2017
28
Homozygous mutation in<i>CEP19,</i>a gene mutated in morbid obesity, in Bardet-Biedl syndrome with predominant postaxial polydactyly. ( 29127258 )
2017
29
Pedunculated Hemorrhagic Cystic Swelling: An Unusual Presentation of Polydactyly. ( 28584766 )
2017
30
On-top and side-to-side plasties for thumb polydactyly. ( 28822893 )
2017
31
Characterization of polydactyly-derived chondrocyte sheets versus adult chondrocyte sheets for articular cartilage repair. ( 29259721 )
2017
32
Noncontiguous Double Spinal Lipoma with Tethered Cord and Polydactyly: Two Different Embryological Events in One Patient. ( 28553379 )
2017
33
Does timing of surgery influence the long-term results of foot polydactyly treatment? ( 29409237 )
2017
34
Mutational screening of GLI3, SHH, preZRS, and ZRS in 102 Chinese children with nonsyndromic polydactyly. ( 28127823 )
2017
35
Incidence of Acute Complications Following SurgeryA for Syndactyly and Polydactyly: An Analysis of the National Surgical Quality Improvement Program Database from 2012 to 2014. ( 28648327 )
2017
36
GLI3-related polydactyly: a review. ( 28224613 )
2017
37
Girl with polydactyly and pigmentary retinopathy. ( 28370859 )
2017
38
Analysis of surgical results and of residual postoperative deformities in preaxial polydactyly of the hand. ( 28579036 )
2017
39
Exome sequencing revealed a splice site variant in the IQCE gene underlying post-axial polydactyly type A restricted to lower limb. ( 28488682 )
2017
40
Achondroplasia with Polydactyly: A Case Report. ( 28511523 )
2017
41
Preaxial polydactyly in an individual with Wiedemann-Steiner syndrome caused by a novel nonsense mutation in KMT2A. ( 28815892 )
2017
42
Isolated heptadactylia: A case report of central polydactyly of the foot. ( 29049244 )
2017
43
Retraction notice to "The identification of loci for polydactyly in chickens using a genome-wide association study" [GENE 568/2 (2015) 176-180]. ( 27049671 )
2016
44
Decision-making and Management of Ulnar Polydactyly of the Newborn: Outcomes and Satisfaction. ( 27595947 )
2016
45
Mutations in DYNC2H1, the cytoplasmic dynein 2, heavy chain 1 motor protein gene, cause short-rib polydactyly type I, Saldino-Noonan type. ( 27925158 )
2016
46
Two cases of polydactyly in wild brown howler monkeys (Alouatta guariba clamitans). ( 26689726 )
2016
47
Identification of novel DYNC2H1 mutations associated with short rib-polydactyly syndrome type III using next-generation panel sequencing. ( 27323140 )
2016
48
Inactivation of Sonic Hedgehog Signaling and Polydactyly in Limbs of Hereditary Multiple Malformation, a Novel Type of Talpid Mutant. ( 28083533 )
2016
49
Mechanism of pancreatic and liver malformations in human fetuses with short-rib polydactyly syndrome. ( 26970085 )
2016
50
An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome. ( 27466187 )
2016

Variations for Polydactyly

ClinVar genetic disease variations for Polydactyly:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MKS1 NM_017777.3(MKS1): c.1115_1117delCCT (p.Ser372del) deletion Pathogenic rs754279998 GRCh37 Chromosome 17, 56285514: 56285516
2 HOXD13 NM_000523.3(HOXD13): c.820C> T (p.Arg274Ter) single nucleotide variant Pathogenic/Likely pathogenic rs200750564 GRCh37 Chromosome 2, 176959246: 176959246

Copy number variations for Polydactyly from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 97909 16 14700000 16700000 Duplication or delet ion polydactyly

Expression for Polydactyly

Search GEO for disease gene expression data for Polydactyly.

Pathways for Polydactyly

GO Terms for Polydactyly

Cellular components related to Polydactyly according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 motile cilium GO:0031514 9.91 BBS2 BBS4 DYNC2H1 DYNC2LI1 GLI2 MKKS
2 ciliary membrane GO:0060170 9.81 BBS1 BBS2 BBS4 BBS7
3 cytoplasmic dynein complex GO:0005868 9.8 DYNC2H1 DYNC2LI1 WDR34 WDR60
4 ciliary tip GO:0097542 9.8 DYNC2H1 DYNC2LI1 GLI2 GLI3 WDR34 WDR35
5 BBSome GO:0034464 9.76 BBS1 BBS2 BBS4 BBS7
6 axoneme GO:0005930 9.76 BBS1 BBS7 DYNC2H1 DYNC2LI1 GLI2 GLI3
7 centriole GO:0005814 9.73 BBS4 MKS1 WDR34
8 ciliary transition zone GO:0035869 9.72 BBS4 DYNC2LI1 MKS1
9 ciliary base GO:0097546 9.71 GLI2 GLI3 WDR60
10 pericentriolar material GO:0000242 9.7 BBS4 NEK1 WDR60
11 ciliary basal body GO:0036064 9.61 BBS1 BBS2 BBS4 BBS7 DYNC2LI1 MKKS
12 cilium GO:0005929 9.4 BBS1 BBS2 BBS4 BBS7 DYNC2H1 DYNC2LI1
13 cytoskeleton GO:0005856 10.22 BBS1 BBS2 BBS4 BBS7 DYNC2H1 DYNC2LI1
14 cell projection GO:0042995 10.1 BBS1 BBS2 BBS4 BBS7 DYNC2H1 DYNC2LI1
15 centrosome GO:0005813 10.06 BBS1 BBS4 BBS7 DYNC2LI1 MKKS MKS1
16 microtubule organizing center GO:0005815 10.02 BBS1 BBS2 BBS4 BBS7 DYNC2LI1 MKKS

Biological processes related to Polydactyly according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.91 GLI2 GLI3 SHH
2 fat cell differentiation GO:0045444 9.91 BBS2 BBS4 BBS7 MKKS
3 anterior/posterior pattern specification GO:0009952 9.9 GLI2 GLI3 SHH
4 lung development GO:0030324 9.89 GLI2 GLI3 SHH
5 palate development GO:0060021 9.89 BBS7 GLI3 SHH
6 protein localization GO:0008104 9.89 BBS2 BBS4 BBS7
7 smoothened signaling pathway GO:0007224 9.89 BBS7 GLI2 GLI3 SHH
8 cerebral cortex development GO:0021987 9.88 BBS2 BBS4 MKKS
9 hippocampus development GO:0021766 9.88 BBS2 BBS4 GLI3 MKKS
10 odontogenesis of dentin-containing tooth GO:0042475 9.87 GLI2 GLI3 SHH
11 pattern specification process GO:0007389 9.87 GLI2 GLI3 SHH
12 heart looping GO:0001947 9.87 BBS4 BBS7 MKKS SHH
13 dorsal/ventral pattern formation GO:0009953 9.86 GLI2 GLI3 SHH
14 limb development GO:0060173 9.86 BBS7 GLI3 SHH
15 positive regulation of multicellular organism growth GO:0040018 9.85 BBS2 BBS4 MKKS
16 intracellular transport GO:0046907 9.83 BBS4 BBS7 MKKS
17 developmental growth GO:0048589 9.83 GLI2 GLI3 SHH
18 photoreceptor cell maintenance GO:0045494 9.83 BBS1 BBS2 BBS4 MKKS
19 spinal cord motor neuron differentiation GO:0021522 9.81 GLI2 GLI3 SHH
20 protein localization to cilium GO:0061512 9.81 BBS1 BBS4 WDR35
21 brain morphogenesis GO:0048854 9.8 BBS2 BBS4 MKKS
22 determination of left/right symmetry GO:0007368 9.8 BBS7 DYNC2LI1 MKKS MKS1 SHH
23 anatomical structure formation involved in morphogenesis GO:0048646 9.79 GLI2 GLI3 SHH
24 prostate gland development GO:0030850 9.78 GLI2 GLI3 SHH
25 branching morphogenesis of an epithelial tube GO:0048754 9.78 GLI2 GLI3 MKS1 SHH
26 anatomical structure development GO:0048856 9.77 GLI2 GLI3 SHH
27 hindbrain development GO:0030902 9.75 GLI2 SHH
28 striatum development GO:0021756 9.75 BBS2 BBS4 MKKS
29 regulation of smoothened signaling pathway GO:0008589 9.74 GLI2 MKS1
30 positive regulation of neuroblast proliferation GO:0002052 9.74 GLI3 SHH
31 embryonic digestive tract morphogenesis GO:0048557 9.74 GLI3 SHH
32 positive regulation of protein import into nucleus GO:0042307 9.74 GLI3 SHH
33 embryonic digestive tract development GO:0048566 9.74 GLI2 GLI3
34 face development GO:0060324 9.74 BBS4 MKKS
35 osteoblast development GO:0002076 9.74 GLI2 SHH
36 embryonic morphogenesis GO:0048598 9.73 GLI3 SHH
37 regulation of stress fiber assembly GO:0051492 9.73 BBS4 MKKS
38 protein localization to organelle GO:0033365 9.73 BBS2 BBS4
39 head development GO:0060322 9.73 GLI2 MKS1
40 digestive tract morphogenesis GO:0048546 9.73 BBS7 SHH
41 intraciliary retrograde transport GO:0035721 9.73 DYNC2H1 DYNC2LI1 WDR35
42 cilium assembly GO:0060271 9.73 BBS1 BBS2 BBS4 BBS7 DYNC2H1 DYNC2LI1
43 negative regulation of actin filament polymerization GO:0030837 9.72 BBS4 MKKS
44 dorsal/ventral neural tube patterning GO:0021904 9.72 GLI2 SHH
45 response to leptin GO:0044321 9.72 BBS2 BBS4 MKKS
46 embryonic digit morphogenesis GO:0042733 9.72 GLI2 GLI3 LMBR1 MKS1 SHH
47 positive regulation of alpha-beta T cell differentiation GO:0046638 9.71 GLI3 SHH
48 negative thymic T cell selection GO:0045060 9.71 GLI3 SHH
49 artery smooth muscle contraction GO:0014824 9.71 BBS2 MKKS
50 leptin-mediated signaling pathway GO:0033210 9.71 BBS2 BBS4 MKKS

Molecular functions related to Polydactyly according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dynein light chain binding GO:0045503 9.33 DYNC2H1 WDR34 WDR60
2 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 9.32 DYNC2H1 DYNC2LI1
3 patched binding GO:0005113 9.26 BBS1 SHH
4 dynein heavy chain binding GO:0045504 9.13 DYNC2LI1 WDR34 WDR60
5 RNA polymerase II repressing transcription factor binding GO:0001103 9.02 BBS1 BBS2 BBS4 BBS7 MKKS

Sources for Polydactyly

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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