Polydactyly malady

Wikipedia: Polydactyly or polydactylism (from Ancient Greek πολύς (polus) \"many\" + δάκτυλος...⁴⁴ more...

MalaCards: Polydactyly, also known as polydactyly, postaxial, is related to postaxial polydactyly type a and beemer-langer syndrome. An important gene associated with Polydactyly is MIPOL1 (mirror-image polydactyly 1), and among its related pathways are Basal cell carcinoma and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The compound cyclopamine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are embryogenesis and mortality/aging.

Aliases & Descriptions:

polydactyly 6 7 30 8 32 polydactyly, postaxial 32 43 postaxial polydactyly 6 7 polydactyly postaxial 30 supernumerary digits 30

polydactylism 30 hyperdactyly 30 extra digits 30 polydactylia 30

Diseases related to polydactyly by text searches and GeneDecks gene sharing:

(show top 50)    (show all 181)

id	Related Disease	Score	Top Affiliating Genes
1	postaxial polydactyly type a	32.9	PAPA3, PAPA2, PAPA4, GPC4, GLI2, GLI3
2	beemer-langer syndrome	32.4	WDR35, UCN2, IFT80, DYNC2H1, NEK1
3	polydactyly preaxial type 4	31.2	GLI3, ACLS
4	mckusick-kaufman syndrome	31.1	BBS1, BBS2, BBS4, BBS7, MKKS, GLI3
5	postaxial polydactyly, type a2	31.1	PAPA2, GPC4, DACH1
6	mirror-image polydactyly	31.0	NBAS, FOXA1, MIPOL1
7	triphalangeal thumb	31.0	LMBR1, MNX1, HOXA13, HOXD13, SHH
8	acrocallosal syndrome	30.0	KIF7, BBS7, IHH, GLI3, ACLS
9	pallister-hall syndrome	29.5	KIF7, MKKS, GLI1, GLI2, GLI3, PTCH1
10	greig cephalopolysyndactyly syndrome	29.2	GLI2, GLI3, ACLS
11	polydactyly, postaxial, types a1 and b	28.7	GLI3, ACLS
12	meckel syndrome	28.2	WDPCP, BBS1, BBS2, BBS4, BBS5, BBS7
13	asphyxiating thoracic dystrophy	28.2	BBS1, BBS4, BBS7, UCN2, ARL13B, CC2D2A
14	tetralogy of fallot	27.7	BBS1, BBS2, BBS4, BBS7, MKKS
15	holoprosencephaly	27.7	BMP4, ZIC2, UBTD2, MNX1, FGF8, FBXW11
16	synpolydactyly	27.5	HOXD11, HOXD12, HOXD13
17	ellis-van creveld syndrome	27.2	WDR19, WDR35, UCN2, MSX1, MKKS, IFT80
18	hypospadias	27.2	BMP4, SALL1, FGF8, FGFR2, ALDH3A2, HOXA13
19	hypothalamic hamartomas	27.1	KIF7, INS, GLI3, ACLS
20	osteochondrodysplasia	27.1	FLNA, FLNC, FLNB, DYNC2H1, SOX9
21	bardet-biedl syndrome	26.2	WDPCP, WDR19, KIF7, SDCCAG8, BBS1, BBS10
22	diabetes mellitus	25.0	WDPCP, KIF7, BMP4, BBS1, BBS12, BBS2
23	obesity	24.1	WDPCP, KIF7, BMP4, BBS1, BBS10, BBS12
24	was-related disorders	23.6	SALL1, CEP290, MKKS, FLNA, FLNC, FLNB
25	retinitis	21.6	KIF7, BMP4, ZIC2, PAX3, SDCCAG8, BBS1
26	triphalangeal thumb-polysyndactyly syndrome	13.9	LMBR1, MNX1, SHH
27	tracheoesophageal fistula	13.8	GLI3, HOXD13, SHH
28	dysostosis	13.7	WDR35, FGFR2, ALX4, EVC, EVC2
29	brachydactyly-syndactyly syndrome	13.7	HOXD11, HOXD12, HOXD13
30	brachydactyly type a1	13.7	IHH, SHH, GDF5
31	congenital heart defect	13.7	BBS2, SALL1, MKKS, EVC, EVC2
32	vacterl association	13.7	GLI1, GLI2, GLI3, HOXD13, SHH
33	clubfoot	13.7	GLI3, HOXA@, HOXD11, HOXD12, HOXD13, GDF5
34	holoprosencephaly, recurrent infections, and monocytosis	13.7	GLI2, PTCH1, SIX3
35	hydrolethalus syndrome	13.7	KIF7, HYLS1
36	multicystic renal dysplasia, bilateral	13.7	CEP290, MKS1, HOXD11, TMEM216, TMEM67
37	bardet-biedl syndrome 12	13.7	BBS10, BBS12
38	acheiropody	13.7	LMBR1, ZP2
39	caudal regression syndrome	13.6	MNX1, SHH
40	sensenbrenner syndrome	13.6	WDR19, WDR35, IFT80, EVC, EVC2, DYNC2H1
41	ectrodactyly	13.6	FGF8, GLI2, DHCR7, SIX3
42	fibular hypoplasia	13.5	MIPOL1, GDF5
43	orofaciodigital syndrome	13.5	CEP290, IFT88, OFD1
44	coach syndrome	13.5	CC2D2A, TMEM67, RPGRIP1L
45	craniosynostosis	13.5	WDR35, MSX2, FGF4, FGF8, FGFR2, IHH
46	tooth agenesis	13.4	BMP4, MSX1, MSX2, MNX1, FGF8
47	congenital hepatic fibrosis	13.4	CC2D2A, TMEM67, RPGRIP1L
48	achondroplasia	13.4	MSX2, FGFR2, IHH, SOX9
49	developmental disabilities	13.4	SALL1, FGFR2, GLI1, GLI3, OFD1, DHCR7
50	enlarged parietal foramina	13.4	MSX2, ALX4

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to polydactyly:

²²

MGI Mouse Phenotypes related to polydactyly:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	embryogenesis phenotype	MP:0005380	INF	WDR19, KIAA0586, KIF7, , BMP4, ZIC2
2	mortality/aging	MP:0010768	INF	WDR19, FOXA1, MKKS, MKS1, FLNA, FLNC
3	taste/olfaction phenotype	MP:0005394	10.4	SIX3, TTC8, SHH, GLI3, MKKS, BBS4
4	hearing/vestibular/ear phenotype	MP:0005377	8.4	FGF8, FGFR2, IFT88, GLI2, GLI3, SHH
5	no phenotypic analysis	MP:0003012	8.4	GLI2, GLI3, HOXD11, HOXD13, PTCH1, SHH
6	muscle phenotype	MP:0005369	8.2	HOXD12, HOXD13, TRIM32, PTCH1, SHH, DHCR7
7	normal phenotype	MP:0002873	8.2	FGF8, FGFR2, ALX3, ALX4, GLI1, GLI2
8	integument phenotype	MP:0010771	7.8	IFT88, ALX4, GLI2, GLI3, HOXA13, HOXD13
9	respiratory system phenotype	MP:0005388	7.0	IHH, IFT88, ALX3, ALX4, GLI1, GLI2
10	endocrine/exocrine gland phenotype	MP:0005379	6.8	PTCH1, HOXD13, HOXA13, GLI3, GLI2, GLI1
11	reproductive system phenotype	MP:0005389	6.7	HOXD12, HOXD11, HOXA13, EVC, GLI3, GLI2
12	renal/urinary system phenotype	MP:0005367	6.7	HOXA13, HOXD11, HOXD13, TMEM67, DYNC2H1, PTCH1
13	homeostasis/metabolism phenotype	MP:0005376	6.0	SHH, DACH1, TRIM32, HOXA13, GLI3, GLI2
14	behavior/neurological phenotype	MP:0005386	6.0	EVC, GLI2, GLI1, ALX4, ALX3, EN2
15	craniofacial phenotype	MP:0005382	5.8	ALX3, HAND2, SIX3, NEK1, ROR2, ALX4
16	digestive/alimentary phenotype	MP:0005381	5.7	WDR19, BMP4, PAX3, SDCCAG8, BBS2, BBS4
17	vision/eye phenotype	MP:0005391	5.6	WDR19, KIF7, BMP4, PAX3, BBS1, BBS2
18	skeleton phenotype	MP:0005390	5.6	KIAA0586, FGFR2, IHH, IFT80, IFT88, ALX3
19	limbs/digits/tail phenotype	MP:0005371	4.9	GLI1, SOX9, ROR2, HAND2, GDF5, DHCR7
20	growth/size phenotype	MP:0005378	4.4	LMBR1, BMP4, PAX3, BBS1, BBS2, BBS4
21	cardiovascular system phenotype	MP:0005385	INF	NPHP3, ROR2, HAND2, KIAA0586, BMP4, ZIC2
22	nervous system phenotype	MP:0003631	INF	ZIC2, ARL13B, FIGN, INPP5E, INS, FGF8
23	cellular phenotype	MP:0005384	INF	TMEM67, HOXD11, GLI3, GLI2, GLI1, IHH

Articles related to polydactyly:

(show all 44)

id	Title	Authors	Year	Affiliating Genes
1	NEK1 mutations cause short-rib polydactyly syndrome t ype majewski. (21211617)	Thiel C.... Rauch A.	2011	NEK1
2	Identification of two novel mutations in Shh long-ran ge regulator associated with familial pre-axial polydactyly. (20569257)	Albuisson J.... Bezieau S.	2011	PAX3, SOX9
3	An interstitial duplication of chromosome 13q31.3q32. 1 further delineates the critical region for postaxial polydactyly type A2. (19941983)	van der Zwaag P.A.... van Ravenswaaij-Arts C.M.	2010	GPC4
4	A specific mutation in the distant sonic hedgehog (SH H) cis-regulator (ZRS) causes Werner mesomelic syndrome (WMS) while complete ZR S duplications underlie Haas type polysyndactyly and preaxial polydactyly (PPD) with or without triphalangeal thumb. (19847792)	Wieczorek D.... Wollnik B.	2010	SHH
5	Preaxial polydactyly/triphalangeal thumb is associate d with changed transcription factor-binding affinity in a family with a novel p oint mutation in the long-range cis-regulatory element ZRS. (20068592)	Farooq M.... Kjaer K.W.	2010	LMBR1
6	Chromosome 14 transfer and functional studies identif y a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyng eal carcinoma. (19667180)	Cheung A.K.... Lung M.L.	2009	MIPOL1
7	Mutation analysis of a large Chinese pedigree with congenital preaxial polydactyly. (19066618)	Li H.... Zhang Y.P.	2009	SHH, MNX1, LMBR1
8	DYNC2H1 mutations cause asphyxiating thoracic dystrophy and short rib-polydactyly syndrome, type III. (19442771)	Dagoneau N.... Cormier-Daire V.	2009	DYNC2H1
9	Homozygous feature of isolated triphalangeal thumb-pr eaxial polydactyly linked to 7q36: no phenotypic difference between homozygotes and heterozygotes. (19519794)	Semerci C.N.... Akarsu N.A.	2009	LMBR1
10	Aberrant FGF signaling, independent of ectopic hedgeh og signaling, initiates preaxial polydactyly in Dorking chickens. (19616534)	Bouldin C.M.... Harfe B.D.	2009	FGF4
11	Ciliary abnormalities due to defects in the retrograde transport protein DYNC2H1 in short-rib polydactyly syndrome. (19361615)	Merrill A.E.... Krakow D.	2009	DYNC2H1
12	Implication of long-distance regulation of the HOXA c luster in a patient with postaxial polydactyly. (19672683)	Lodder E.M.... de Graaff E.	2009	HOXA@
13	Point mutations in a distant sonic hedgehog cis-regulator generate a variable regulatory output responsible for preaxial polydactyly. (18156157)	Lettice L.A.... Hill R.E.	2008	SHH
14	Holoprosencephaly-Polydactyly syndrome: in search of an etiology. (18178536)	Cordero D.R.... Muenke M.	2008	SHH, GLI3, ZIC2
15	Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog. (18272352)	Babbs C.... Wilkie A.O.	2008	GLI3, HAND2
16	Hydrometrocolpos, postaxial polydactyly, and hypothalamic hamartoma in a patient with confirmed Pallister-Hall syndrome: a clinical overlap with McKusick-Kaufman syndrome. (18478223)	Kos S.... Eich G.	2008	GLI3
17	The molecular basis of Pallister Hall associated polydactyly. (17588959)	Hill P.... Ruther U.	2007	GLI3
18	Two novel point mutations in the long-range SHH enhancer in three families with triphalangeal thumb and preaxial polydactyly. (17152067)	Gurnett C.A.... Dobbs M.B.	2007	SHH, LMBR1
19	Hemizygosity for chromosome 2q14.2-q22.1 spanning the GLI2 and PROC genes associated with growth hormone deficiency, polydactyly, deep vein thrombosis and urogenital abnormalities. (16650085)	Gustavsson P.... Dahl N.	2006	PROC
20	Single nucleotide polymorphisms in the chicken Lmbr1 gene are associated with chicken polydactyly. (16650944)	Huang Y.Q.... Li N.	2006	LMBR1
21	Holoprosencephaly and preaxial polydactyly associated with a 1.24 Mb duplication encompassing FBXW11 at 5q35.1. (16865294)	Koolen D.A.... de Vries B.B.	2006	GLI3, FBXW11
22	Crossed polydactyly type I caused by a point mutation in the GLI3 gene in a large Chinese pedigree. (16874813)	Cheng B.... Xiao C.	2006	GLI3
23	A new osteochondrodysplasia with severe osteopenia, preaxial polydactyly, clefting and dysmorphic features resembling filamin-related disorders. (17009344)	Colombani M.... Faivre L.	2006	FLNA, FLNB, FLNC
24	Apert syndrome with preaxial polydactyly showing the typical mutation Ser252Trp in the FGFR2 gene. (16440883)	Mantilla-Capacho J.M.... Barros-Nunez P.	2005	FGFR2
25	Molecular analysis of non-syndromic preaxial polydactyly: preaxial polydactyly type-IV and preaxial polydactyly type-I. (15811011)	Fujioka H.... Sakiyama Y.	2005	GLI3
26	A female with complete lack of Mullerian fusion, postaxial polydactyly, and tetralogy of fallot: genetic heterogeneity of McKusick-Kaufman syndrome or a unique syndrome? (15266619)	Slavotinek A.M.... Stratton P.	2004	BBS4, BBS2, MKKS
27	Mutations in the EVC1 gene are not a common finding in the Ellis-van Creveld and short rib-polydactyly type III syndromes. (15368503)	Takamine Y.... Wilcox W.R.	2004	EVC
28	A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly. (12837695)	Lettice L.A.... de Graaff E.	2003	SHH, LMBR1
29	A new locus for postaxial polydactyly type A/B on chromosome 7q21-q34. (12734547)	Galjaard R.J.... Heutink P.	2003	GLI3, PAPA2, PAPA4
30	A new syndrome of symphalangism, multiple frenula, postaxial polydactyly, dysplastic ears, dental anomalies, and exclusion of NOG and GDF5. (12838559)	Kantaputra P.N.... Limwongse C.	2003	GDF5
31	Disruption of the C7orf2/Lmbr1 genic region is associated with preaxial polydactyly in humans and mice. (12491086)	Horikoshi T.... Noji S.	2003	LMBR1
32	Postaxial polydactyly type A/B (PAP-A/B) is linked to chromosome 19p13.1-13.2 in a Chinese kindred. (11973619)	Zhao H.... Heutink P.	2002	GLI3, PAPA3
33	Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly. (12032320)	Lettice L.A.... Noji S.	2002	SHH, LMBR1
34	A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet. (11954550)	Kondoh S.... Yoshiura K.	2002	FOXA1, NBAS, MIPOL1
35	Dach: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homolog. (11543628)	Ayres J.A.... Nuckolls G.H.	2001	DACH1
36	A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of Hemimelic extra-toes mutant mice. (10945466)	Clark R.M.... Kingsley D.M.	2000	LMBR1
37	A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36. (10329000)	Heus H.C.... Heutink P.	1999	MNX1, NOM1, LMBR1
38	The phenotypic spectrum of GLI3 morphopathies includes autosomal dominant preaxial polydactyly type-IV and postaxial polydactyly type- A/B; no phenotype prediction from the position of GLI3 mutations. (10441570)	Radhakrishna U.... Antonarakis S.E.	1999	GLI3
39	A case of familial Bardet-Biedl syndrome (obesity, slight mental retardation, polydactyly, retinitis pigmentosum and renal failure) with insulin-resistant diabetes mellitus (10063326)	Iannello S.... Belfiore F.	1998	INS
40	Analysis of the human Sonic Hedgehog coding and promoter regions in sacral agenesis, triphalangeal thumb, and mirror polydactyly. (9600232)	Vargas F.R.... Muenke M.	1998	SHH
41	Pre- and postnatal growth retardation, scaling skin, moderate mental retardation and quadrispasticity, hypospadias grade 2 and hydro-uretero nephrosis, postaxial polydactyly. A distinct MCA/MR syndrome? (9823494)	Fryns J.P.... Rizzo W.B.	1998	ALDH3A2
42	Mapping one form of autosomal dominant postaxial polydactyly type A to chromosome 7p15-q11.23 by linkage analysis. (9042919)	Radhakrishna U.... Antonarakis S.E.	1997	GLI3
43	Mutation in GLI3 in postaxial polydactyly type A. (9354785)	Radhakrishna U.... Antonarakis S.E.	1997	GLI3
44	Linkage of preaxial polydactyly type 2 to 7q36. (8533803)	Hing A.V.... Donis-Keller H.	1995	LMBR1

Genes related to polydactyly according to GeneCards:

(show top 50)    (show all 107)

id	Symbol	Description	Score	GeneCards Section Context
1	MIPOL1	mirror-image polydactyly 1	11.1	Transcripts, Orthologs, Aliases & Descriptions, Summaries (show all 6 sections) Proteins, Publications
2	GLI3	GLI family zinc finger 3	11.1	Publications, Summaries
3	DYNC2H1	dynein, cytoplasmic 2, heavy chain 1	11.1	Publications, Summaries
4	GLI2	GLI family zinc finger 2	11.1	Summaries
5	LMBR1	limb region 1 homolog (mouse)	11.1	Summaries, Publications
6	PAPA4	Polydactyly, postaxial, type A4	11.1	Aliases & Descriptions, Publications
7	PAPA3	Polydactyly, postaxial, type A3	11.1	Publications, Aliases & Descriptions
8	PAPA2	postaxial polydactyly, type A2	11.1	Aliases & Descriptions, Publications
9	SHH	sonic hedgehog	11.0	Summaries, Publications
10	TTC8	tetratricopeptide repeat domain 8	11.0	Summaries
11	BBS2	Bardet-Biedl syndrome 2	11.0	Publications, Summaries
12	BBS4	Bardet-Biedl syndrome 4	11.0	Summaries, Publications
13	BBS10	Bardet-Biedl syndrome 10	11.0	Summaries
14	BBS5	Bardet-Biedl syndrome 5	11.0	Summaries
15	INPP5E	inositol polyphosphate-5-phosphatase, 72 kDa	11.0	Summaries
16	BBS7	Bardet-Biedl syndrome 7	11.0	Summaries, Publications
17	NEK1	NIMA (never in mitosis gene a)-related kinase 1	11.0	Publications
18	ACLS	acrocallosal syndrome	11.0
19	GPC4	glypican 4	11.0	Publications
20	DACH1	dachshund homolog 1 (Drosophila)	11.0	Publications
21	BMP4	bone morphogenetic protein 4	11.0
22	UCN2	urocortin 2	11.0
23	WDR35	WD repeat domain 35	11.0
24	FOXA1	forkhead box A1	11.0	Publications
25	BBS1	Bardet-Biedl syndrome 1	11.0	Publications
26	OFD1	oral-facial-digital syndrome 1	11.0
27	HOXD13	homeobox D13	11.0
28	MKKS	McKusick-Kaufman syndrome	11.0	Publications
29	EVC	Ellis van Creveld syndrome	11.0	Publications
30	IFT80	intraflagellar transport 80 homolog (Chlamydomonas)	11.0
31	EVC2	Ellis van Creveld syndrome 2	11.0
32	NBAS	neuroblastoma amplified sequence	11.0	Publications
33	FGFR2	fibroblast growth factor receptor 2	11.0	Publications
34	LINC00244	long intergenic non-protein coding RNA 244	11.0	Publications
35	HOXA@	homeobox A cluster	11.0	Publications
36	TMEM216	transmembrane protein 216	11.0
37	MNX1	motor neuron and pancreas homeobox 1	11.0	Publications
38	KIF7	kinesin family member 7	11.0
39	MKS1	Meckel syndrome, type 1	11.0
40	TRIM32	tripartite motif containing 32	11.0
41	LZTFL1	leucine zipper transcription factor-like 1	11.0	Disorders
42	B9D2	B9 protein domain 2	11.0
43	BBS12	Bardet-Biedl syndrome 12	11.0
44	HOXA13	homeobox A13	11.0
45	HAND2	heart and neural crest derivatives expressed 2	11.0	Publications
46	HYLS1	hydrolethalus syndrome 1	11.0
47	HOXD12	homeobox D12	11.0
48	HOXD11	homeobox D11	11.0
49	NOM1	nucleolar protein with MIF4G domain 1	11.0	Disorders, Publications
50	ZIC2	Zic family member 2	11.0	Publications

Pathways related to polydactyly according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Basal cell carcinoma20	10.0	WNT8B, SHH, PTCH1, GLI3, GLI2, GLI1
2	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	9.9	SHH, PTCH1, GLI2, GLI1, IHH
3	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	9.8	SHH, PTCH1, GLI2, GLI1, IHH
4	Hedgehog signaling pathway20	9.8	BMP4, WNT8B, SHH, PTCH1, GLI3, GLI2
5	Nanog in Mammalian ESC Pluripotency36	9.6	WNT8B, ROR2, FGFR2, FGF8, FGF4, BMP4
6	Pathways in cancer20	9.4	WNT8B, SHH, PTCH1, GLI3, GLI2, GLI1

Compounds related to polydactyly according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	cyclopamine32	9.9	BMP4, IHH, GLI1, PTCH1, SHH

Cellular components related to polydactyly according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	motile cilium	GO:031514	10.1	NPHP1, MKKS, BBS4, BBS2, WDR19
2	BBSome	GO:034464	9.7	BBS1, BBS2, BBS4, BBS5, BBS7, BBS9
3	cilium membrane	GO:060170	9.6	BBS1, BBS2, BBS4, TTC8, TMEM67, EVC2
4	photoreceptor connecting cilium	GO:032391	9.6	NPHP1, IFT88, IFT52, CEP290, WDR19
5	TCTN-B9D complex	GO:036038	9.4	TCTN2, AHI1, TMEM67, TMEM216, CC2D2A, MKS1
6	nonmotile primary cilium	GO:031513	9.3	WDR19, BBS4, AHI1
7	cilium axoneme	GO:035085	9.3	NPHP1, TTC21B, RPGRIP1L, DYNC2H1, IFT88, IFT80
8	cilium	GO:005929	9.1	NPHP3, AHI1, RPGRIP1L, OFD1, KIF7, BBS10
9	microtubule basal body	GO:005932	8.5	WDR19, TMEM67, TMEM216, EVC2, EVC, IFT88
10	centrosome	GO:005813	INF	NEK1, TTC8, AHI1, C2CD3, RPGRIP1L, OFD1
11	ciliary transition zone	GO:035869	INF	, CC2D2A, B9D1
12	centriole	GO:005814	INF	SDCCAG8, BBS4, , IFT88, OFD1, AHI1
13	primary cilium	GO:072372	INF	, AHI1, NPHP3

Biological processes related to polydactyly according to GeneDecks:

(show top 50)    (show all 85)

id	Name	GO ID	Score	Top Affiliating Genes
1	cilium assembly	GO:042384	INF	TMEM216, CC2D2A, FLNA, MKS1, MKKS,
2	negative regulation of appetite by leptin-mediated signaling pathway	GO:038108	10.8	MKKS, BBS4, BBS2
3	nonmotile primary cilium assembly	GO:035058	10.8	BBS4, BBS1, BBS10, MKKS
4	pigment granule aggregation in cell center	GO:051877	10.8	BBS7, MKKS, BBS4
5	melanosome transport	GO:032402	10.8	MKKS, BBS7, BBS2, BBS4, BBS5, ARL6
6	hindgut morphogenesis	GO:007442	10.8	SHH, GLI2, GLI3
7	photoreceptor cell maintenance	GO:045494	10.8	BBS10, BBS1, BBS4, BBS2, NPHP3, MKKS
8	negative regulation of alpha-beta T cell differentiation	GO:046639	10.8	SHH, GLI3, IHH
9	regulation of cilium beat frequency involved in ciliary motility	GO:060296	10.8	BBS4, MKKS, BBS2
10	convergent extension involved in gastrulation	GO:060027	10.8	BBS4, NPHP3, MKKS
11	embryonic digestive tract morphogenesis	GO:048557	10.6	SHH, GLI3, IHH, FGFR2
12	regulation of branching involved in prostate gland morphogenesis	GO:060687	10.6	BMP4, FGFR2, HOXD13
13	odontogenesis of dentin-containing tooth	GO:042475	10.6	BMP4, MSX1, FGF4, SHH, HAND2, GLI2
14	ventral midline development	GO:007418	10.6	GLI2, SHH, GLI1
15	male genitalia development	GO:030539	10.5	SHH, HOXA13, HOXD13, FGF8
16	mesenchymal cell proliferation	GO:010463	10.5	MSX1, FGF4, HAND2
17	positive regulation of chondrocyte differentiation	GO:032332	10.5	GDF5, SOX9, HOXD11, GLI3, IHH
18	branching involved in prostate gland morphogenesis	GO:060442	10.5	BMP4, FGFR2, HOXA13
19	positive regulation of smoothened signaling pathway	GO:045880	10.5	EVC, KIF7, IHH, SHH, GLI1
20	otic vesicle formation	GO:030916	10.5	FGFR2, CEP290, SOX9, FGF8
21	branching involved in ureteric bud morphogenesis	GO:001658	10.5	HOXD11, SOX9, BMP4, SALL1, FGF8, GLI3
22	branching morphogenesis of a tube	GO:048754	10.4	MKS1, BMP4, GLI2, SHH
23	negative regulation of smoothened signaling pathway	GO:045879	10.4	GLI3, PTCH1, KIF7, SALL1
24	lung development	GO:030324	10.4	FGFR2, GLI3, SHH, DHCR7, GLI1, GLI2
25	cranial suture morphogenesis	GO:060363	10.4	MSX2, FGF4, BMP4
26	proximal/distal pattern formation	GO:009954	10.4	GLI1, GLI2, GLI3, HOXD11
27	skeletal system development	GO:001501	10.4	HOXA13, HOXD12, EVC, HOXD13, SOX9, GLI2
28	pattern specification process	GO:007389	10.4	GLI2, HOXD12, SHH, ALX3
29	positive regulation of T cell differentiation in thymus	GO:033089	10.3	IHH, SHH, GLI2
30	regulation of odontogenesis of dentin-containing tooth	GO:042487	10.3	IFT88, BMP4, FGF8
31	osteoblast differentiation	GO:001649	10.2	MSX2, BMP4, IHH, GLI1, GLI2
32	positive regulation of proteolysis	GO:045862	10.2	TRIM32, IFT88, IFT52, FBXW11
33	pituitary gland development	GO:021983	10.2	GLI1, GLI2, SALL1, BMP4
34	determination of left/right symmetry	GO:007368	10.2	NPHP3, BBS7, DYNC2H1, IFT88, ARL13B, ARL6
35	embryonic forelimb morphogenesis	GO:035115	10.2	MSX1, MSX2, ALX3, ALX4, HOXA13, RPGRIP1L
36	anterior/posterior pattern specification	GO:009952	10.1	SHH, MSX1, IFT88, ALX4, HOXD11, HOXD13
37	regulation of smoothened signaling pathway	GO:008589	10.1	GLI1, PTCH1, RPGRIP1L, FGFR2
38	embryonic digit morphogenesis	GO:042733	10.1	HOXD13, HOXD11, SHH, HAND2, HOXD12, GLI3
39	hindbrain development	GO:030902	10.1	CEP290, EN2, AHI1, GLI2, SHH
40	embryonic hindlimb morphogenesis	GO:035116	10.0	SHH, ALX4, ALX3, FGF8, FGF4, MSX2
41	negative regulation of canonical Wnt receptor signaling pathway	GO:090090	10.0	SOX9, SHH, ROR2, GLI3, GLI1, NPHP3
42	renal system development	GO:072001	9.9	SHH, PTCH1, BMP4
43	fat cell differentiation	GO:045444	9.9	ARL6, TRIM32, BBS7, BBS9, MKKS, BBS4
44	dorsal/ventral pattern formation	GO:009953	9.9	IFT52, ARL13B, IFT88, GLI1, HOXD11, SHH
45	heart looping	GO:001947	9.8	HAND2, AHI1, SHH, IFT52, IHH, FGF8
46	smoothened signaling pathway	GO:007224	9.5	TCTN2, SHH, EVC2, GLI3, GLI2, GLI1
47	positive regulation of transcription, DNA-dependent	GO:045893	9.4	HAND2, SHH, SOX9, GLI2, ROR2, GLI3
48	negative regulation of apoptotic process	GO:043066	9.0	AHI1, SHH, SOX9, GLI3, IHH, FGF4
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.9	HOXA13, HAND2, SIX3, BMP4, SOX9, AHI1
50	cilium morphogenesis	GO:060271	8.8	BBS2, BBS4, BBS7, B9D1, CEP290, MKKS

Molecular functions related to polydactyly according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	HAND2, OFD1, DACH1, PTCH1, TMEM67, TRIM32
2	sequence-specific DNA binding transcription factor activity	GO:003700	9.4	GLI2, GLI3, HOXA13, HOXD11, HOXD12, HOXD13
3	sequence-specific DNA binding	GO:043565	9.1	GLI3, HOXA13, HOXD11, HOXD12, HOXD13, SIX3