MCID: PLY006
MIFTS: 49

Polydactyly malady

Rare diseases, Bone diseases, Fetal diseases categories

Aliases & Classifications for Polydactyly

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Aliases & Descriptions for Polydactyly:

Name: Polydactyly 10 45 47 12 36
Polydactyly, Postaxial 47 65
Postaxial Polydactyly 10
Supernumerary Digits 45
 
Polydactylism 45
Extra Digits 45
Polydactylia 45
Hyperdactyly 45


Classifications:



External Ids:

Disease Ontology10 DOID:1148
ICD9CM29 755.00, 755.0
NCIt42 C87110
MeSH36 D017689
ICD1027 Q69

Summaries for Polydactyly

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NIH Rare Diseases:45 Polydactyly is a condition in which a person has more than five fingers per hand or five toes per foot. it is the most common birth defect of the hand and foot. polydactyly can occur as an isolated finding such that the person has no other physical anomalies or intellectual impairment. however, it can occur in association with other birth defects and cognitive abnormalities as part of a genetic syndrome. in some cases, the extra digits may be well-formed and functional. surgery may be considered especially for poorly formed digits or very large extra digits. surgical management depends greatly on the complexity of the deformity. last updated: 5/8/2015

MalaCards based summary: Polydactyly, also known as polydactyly, postaxial, is related to short-rib thoracic dysplasia 6 with or without polydactyly and polydactyly, preaxial type ii. An important gene associated with Polydactyly is GLI3 (GLI Family Zinc Finger 3), and among its related pathways are Intraflagellar transport and Signaling by Hedgehog. Affiliated tissues include bone, heart and kidney, and related mouse phenotypes are hearing/vestibular/ear and taste/olfaction.

Wikipedia:68 Polydactyly or polydactylism (from Greek πολύς (polys), meaning \"many\", and δάκτυλος... more...

Related Diseases for Polydactyly

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Diseases in the Polydactyly family:

Central Polydactyly of Toes

Diseases related to Polydactyly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 485)
idRelated DiseaseScoreTop Affiliating Genes
1short-rib thoracic dysplasia 6 with or without polydactyly31.2DYNC2H1, NEK1
2polydactyly, preaxial type ii31.1LMBR1, SHH
3short-rib thoracic dysplasia 3 with or without polydactyly30.9DYNC2H1, NEK1, WDR34, WDR35, WDR60
4laurin-sandrow syndrome30.7LMBR1, MIPOL1, SHH
5polydactyly of an index finger, unilateral30.6LMBR1, SHH
6postaxial polydactyly type a, unilateral30.5LMBR1, SHH
7syndactyly, type iv30.5LMBR1, SHH
8pallister-hall syndrome30.4GLI3, MKKS, SHH
9ellis-van creveld syndrome30.2DYNC2H1, EVC, NEK1, WDR34, WDR35, WDR60
10bardet-biedl syndrome 329.9BBS1, BBS2
11bardet-biedl syndrome 1329.5BBS1, BBS4, TTC8
12bardet-biedl syndrome 129.2BBS1, BBS2, BBS4, BBS7, LZTFL1, MKKS
13bardet-biedl syndrome 629.0BBS1, BBS2, BBS4, BBS7, GLI3, MKKS
14bardet-biedl syndrome 1228.9BBS1, BBS2, BBS4, BBS7, LZTFL1, MKKS
15tetralogy of fallot28.9BBS1, BBS2, BBS4, BBS7, MKKS
16obesity28.5BBS1, BBS2, BBS4, BBS7, LZTFL1, MKKS
17polydactyly, postaxial, types a1 and b10.5
18syndactyly10.5
19beemer-langer syndrome10.5
20tibia absent polydactyly arachnoid cyst10.5
21polydactyly, preaxial, type iv10.5
22greig cephalopolysyndactyly syndrome10.4
23triphalangeal thumb10.4
24short-rib thoracic dysplasia 7 with or without polydactyly10.4
25acrocallosal syndrome10.4
26mckusick-kaufman syndrome10.4
27bardet-biedl syndrome10.4
28short-rib thoracic dysplasia 8 with or without polydactyly10.4
29meckel syndrome 110.4
30preaxial polydactyly type 110.4
31syndactyly-polydactyly-earlobe syndrome10.4
32hypoplastic or aplastic tibia with polydactyly10.3
33dandy-walker malformation with postaxial polydactyly10.3
34polydactyly myopia syndrome10.3
35megalencephaly10.3
36short-rib thoracic dysplasia 10 with or without polydactyly10.3
37short-rib thoracic dysplasia 2 with or without polydactyly10.3
38short-rib thoracic dysplasia 11 with or without polydactyly10.3
39short-rib thoracic dysplasia 14 with polydactyly10.3
40megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 110.3
41guttmacher syndrome10.3
42hydrocephalus10.3
43polymicrogyria10.3
44orofaciodigital syndrome v10.3
45short-rib thoracic dysplasia 4 with or without polydactyly10.3
46short-rib thoracic dysplasia 5 with or without polydactyly10.3
47orofaciodigital syndrome vi10.3
48smith-lemli-opitz syndrome10.3
49short-rib thoracic dysplasia 9 with or without polydactyly10.3
50imperforate anus10.3

Graphical network of the top 20 diseases related to Polydactyly:



Diseases related to polydactyly

Symptoms for Polydactyly

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Drugs & Therapeutics for Polydactyly

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Drugs for Polydactyly (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Mentholapproved17482216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
999 Itch Relief
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
Absorbine Back Therapeutic Pain Relief
Absorbine Jr
Absorbine Jr Ultra Strength Pain Relieving
Absorbine Jr.
Absorbine Jr. Back
Algomend Pain Relief
Alhua Huogan Pain Relieving Patch
Aloemint Skin Aid
Amar Ice
Analgesic
Anc Neverpain External Analgesic
Anti Itch
Army Health Pain Reliever
Arthri-support
Arthri-zen Relief
Arthripain Relief
Arthritis Relief
Aspercreme Heat
Aspercreme Max No Mess Roll On
Assured Cold N Hot Pain Relief Menthol
Assured Extra Strength Cold N Hot
Assured Ice Cold Topical Analgesic
Assured Muscle Rub
Assured Pain Relief Hot Menthol
Atopalm Pain Relieving
Aurorae Healing Pain Relieving Roll-on
Avapta
Avedana Pain Relieving Roll On
Avedana Pain-relieving
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
Babyganics Cold Relief Chest Rub
Barox
Barox BODY CARE MASSAGE
Barox Body Care Massage Relax Refresh Revital
Being Well Extra Strength Menthol Heat
Bengay Ultra Strength Large Size
Bengay Ultra Strength Pain Relieving Large Size
Bengay Ultra Strength Pain Relieving Regular Size
Bengay Ultra Strength Regular Size
Bengay Vanishing Scent
Bengay Zero Degrees Menthol Pain Relieving
Bentasil SUGAR FREE BLACKCURRANT SOFT Texture
Bentasil SUGAR FREE CHERRY SOFT Texture
Bentasil SUGAR FREE HONEY LEMON SOFT Texture
Berri-freez
Besthealth Cherry
Besthealth Cough Suppressant Sugar Free Black Cherry Flavor
Besthealth Cough Suppressant Sugar Free Honey Lemon Flavor
Besthealth Honey Lemon
Besthealth Menthol
Bio 2 Brazilian Heat Brazilian Heat
Bio-scriptives Extreme Pr
Bioblast Pain Relief
Bioflexor
Biofreeze
Biofreeze Colorless
Biofreeze Colorless Roll-on
Biofreeze Roll-on
Biorelief Ice Pain Relieving
Blistex Ivarest Medicated Poison Ivy Cleansing Foam
Blue Gel Pain Relieving
Blue Ice
Blue Ice Analgesic
Blue Ice Analgesic Gel
Blue Ice Pain Relieving
Body
Budpack Muscle Rub
Budpak Muscle Rub
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Canker Complete Canker Sore Relief
Caswell No. 540
Celadrin
Cepacol Sore Throat From Post Nasal Drip
Cepacol Sore Throat Regular Strength
Ching Wan Hung Soothing Herbal Balm
Choice Personal Care Theraputic Blue Ice
Cold Hot Patch
Cold Spot Point Relief
Coldaid
Cool N Heat Patch For Back Extra Strength
Coralite Extra Strength Menthol Pain Relief Sleeve - Knee
Coralite Extra Strength Menthol Pain Relief Sleeve - Wrist
Coralite Pain Relief
Counteract Cough Drops Honey Lemon
Counteract Cough Drops Orchard Cherry
Cryogel Island Rain Natural Pain Relieving Vitaminerals
Cvs Cold Hot Medicated
Cvs Soothing Itch Relief
Cvs Sore Muscle Rub Vanishing Scent
Cvs Therapeutic Menthol Gel
Cvs Therapeutic Menthol Pain Reliever
Cvs Tropical Citrus Cough
Cvs Ultra Strength Pain Relieving
Cvs Vanishing Scent Muscle Rub
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
Dg Health Extra Strength Medicated
Dg Health Pain Relieving
Dg Ice Cold Analgesic
Diapedic Foot Treatment
DivK1c_000820
Dorflex Icy Hot Flexible, Large
Dorflex Icy Hot Flexible, Small
Dorflex Icy Hot Flexible, XL
Dr. Blue
Dt Ice Cold Analgesic
Dual Action Cherry Cough Suppressant Oral Anesthetic
Dynafreeze
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
Easy
Eb301ap Pain Relief
Eb301ct Bruise Pain Relief
Eb302 Arthritis Relief
Ecolyptus Pain Relieving Muscle Rub
Efac Pain Relieving
Elgin Pain Relief
Equaline Blue Ice Pain Relieving
Equate Menthol Extra Strength
Eros Iron Man
Eucalyptamint
Eucerin Calming Itch Relief Treatment
Extra Strength Cold N Hot Pain Relief Medicated
Extra Strength Pain Relief Therapy
Extra Strength Stopain Cold Pain Relieving
Extra Strength Stopain Cold Pain Relieving Roll On
FEMA No. 2665
Family Care Maximum Strength Medicated Anti Itch
Fast Freeze
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
Flexall Pain Relieving
Flexgen
Fluaid
Foot Works Achy Foot Massager Pain Relieving
Gold Bond Foot Extra Strength
Gold Bond Medicated Foot
Gold Bond Pain Relieving Foot
Gold Bond Pain Relieving Foot Roll On
Green Bamboo
Green Guard Cough Drop Relief
HMS1922G13
HMS2092L14
HMS502I22
HSDB 5662
HSDB 593
Halls Apple Cider
Halls Butterscotch
Halls Cherry
Halls Extra Strong Menthol
Halls Honey Lemon
Halls Ice Peppermint
Halls MENTHO-LYPTUS
Halls Melon Splash
Halls Menthol
Halls Mentholyptus
Halls Mocha Mint
Halls Naturals Honey Lemon Chamomile
Halls Plus Cherry
Halls Plus Honey
Halls Plus Strawberry
Halls Spearmint
Halls Strawberry
Halls Sugar Free Black Cherry
Halls Sugar Free Citrus Blend
Halls Sugar Free Extra Strong Menthol
Halls Sugar Free Honey Berry
Halls Sugar Free Honey Lemon
Halls Sugar Free Mountain Menthol
Halls Tropical Fruit
Hallsmelon Splash Melon Splash
Hallssugar Free Extra Sugar Free Extra Strong Menthol
Han Honey Loquat Syrup
Hanbang Cataplasma
Harmon Extra Strength Pain Relieving
Harmon Extra Strength Pain Relieving Roll-on
Headache crystals
Health Smart Medicated Foot
Herbion Naturals Honey Lemon
Herbion Naturals Honey Lemon Cough Drops
Herbion Naturals Honey-Lemon Cough Drops
Herbion Naturals Mint Cough Drops
Herbion Naturals Orange
Herbion Naturals Orange Cough Drops
Hexahydrothymol
Hielo Ardiente
Honibe
 
Hot Ice Soothing Analgesic Gel
Huitomi Slimming Sports
Humphreys Bendito Alcoholado
I06-1216
I14-7371
IDI1_000820
Ice
Ice Cold Analgesic
Ice Cold Topical Analgesic Gel
Ice External Analgesic Leader
Ice Quake
Ice Quake Muscle Rub
Icy Cool Maximum Strength
Icy Hot
Icy Hot Back
Icy Hot Medicated
Icy Hot Medicated No Mess Applicator
Icy Hot Medicated Roll Large
Icy Hot Medicated Roll Medium
Icy Hot Medicated Roll, Large
Icy Hot Medicated Roll, Medium
Icy Hot Medicated, Advanced Relief
Icy Hot Medicated, Back
Icy Hot Medicated, XL
Icy Hot Naturals
Icy Hot Power Gel
Icy Hot Vanishing Scent
Icyhot Medicated
Imada Four Seasons Safe Analgesic Balm
Jakemans Blueberry
Jakemans Cherry
Jakemans Peppermint
K2 Cold Therapy
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
Kay Medic Menthol Pain Relief
Kool Comfort
Kool Comfort Pain Relieving Roll-on
Kpp Triple Action
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
La Jiao Feng Shi Gao
Lander Polar Ice
Leader Cough Drops Cherry Flavor
Leader Cough Drops Honey Lemon
Leader Cough Drops Menthol Flavor
Leader Extra Strength Medicated Pain Relief Patch
Leader Sugar Free Cough Drops Black Cherry
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
Linkus Lozenges Cough Suppressant/Oral Anesthetic
Low Sugar Cherry Flavor Fishermans Friend Menthol Cough Suppressant
Ludens Honey Lemon Throat Drops
Ludens Honey Licorice Throat Drops
Ludens Original Menthol Throat Drops
Lurosil
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Makesense Extra Strength Muscle Rub
Maxfit Freeze Gel
Maybelline New York Baby Lips Dr Rescue Medicated Balm
Medi First Plus Cherry Cough Drops
Medi-first Cherry Cough Drops
Medic Ice
Medicated Body Powder
Medicated Pain Relief
Mediflex
Medique Medikoff Drops
Medique Sugar Free Medikoff Drops
Meditowel PAIN RELIEF
Meijer Cherry Cough Drops
Meijer Honey Lemon Cough Drops
Meijer Menthol Cough Drops
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol Fresh Cough Suppressant
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Mentholatum Pain Relief Extra Strength
Mentholatum Sports Pain Relief Cold
Menthomenthol
Menthyl alcohol
Mineral Ice Pain Relieving
Miracle Foot Repair
Miracle Foot Repair Cream
Miracle Of Aloe Rub Roll On
Miracle Pain Cream
Moisture Therapy Anti-Itch
MolPort-000-849-729
MolPort-001-793-392
Moore Medical Cherry Cough Suppressant/anesthetic Drops
Moore Medical Sugar Free Black Cherry Cough Suppressant/anesthetic Drops
Moore Medical Sugar Free Menthol Cough Suppressant/anesthetic Drops
Mr Dudleys Topical Pain Relief
Muscle
Muscle Rub Ultra Strength Pain Relieving
Myo-breathe
Myorx Low Dose Pain Relieving
Myorx Pain Relieving
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Nan San Easy Flex Pain Relieving
Natural Cherry Honey Herb Throat Drops
Natural Herb cough drop
Natural Honey Herb Cough Suppressant Throat Drops
Natural Lemon Mint Herb Throat Drops
Natural Pain Relieving Lavender Breeze Cryogel
Natures Choice Cool Hot Ice
Natures Sunshine Products Everflex Topical Analgesic Pain Relief
Neoisomenthol
Nice Assorted
Nice Cherry
Nice Citrus
Nice Cool Mint
Nice Honey Lemon
Nice Menthol
No Pain More Gain
North Cough Drop
Numotizine
Olbas Lozenges Maximun Strength
Olbas Pastilles
Original Extra Strong All Natural Fishermans Friend Menthol Cough Suppressant
Ortho-nesic
Osmoflex
Oxyrub Pain Relief
Pain Relief Balmpreferred Plus Ph Preferred Plus Pharmacy
Pain Relief Therapy Patch
Pain Reliever
Pain Relieving
Pain Relieving Analgesic
Pain Relieving Patch
Pain Relieving Patch Ultra Strength
Pain Relieving Patch Ultra Strength ULTRA STRENGTH
Panitrol XR
Paraid Extra Strength Menthol Pain Relief Sleeve Knee Large Ankles Elbows
Patch Scherer Labs
Patch Walgreens
Peppermint camphor
Perfect Purity Hotice
Perfect Purity Medicated Foot Powder
Perform
Personal Care Extra Strength Cold Hot
Personal Care Ice Cold
Plaster MandAHerbalPlaster
Po Sum On Medicated
Polar Frost Cold
Power Relief
Preferred Plus Body Powder
Premier Value Medicated Foot Powder
Q Health Pain Relief Spray
Quickflex
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Raw Heat
Raw Ice
Reactice Reactivating Ice Baume
Red Lion Relief
Relief Pain Relieving Cream
Rexall Vanishing Scent Pain Relieving
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Screamin Menthol Toast
Sella Natural
Skin So Soft Bug Guard Plusitch Relief itch relief
Smith Bros Honey Lemon Cough Drops
Smith Bros Menthol Eucalyptus Cough Drops
Smith Bros Sugar-free Black Cherry Cough Drops
Sof Skin Icy Blue
Sofskin Ice Analgesic
Sombra Cool Therapy
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Stopain Cold Pain Relieving
Stopain Cold Professional Strength Pain Relieving
Stopain Extra Strength Pain Relieving
Sub-zero COOL PAIN RELIEVING
Sugar Free Cherry Fishermans Friend Menthol Cough Suppressant
Sugar Free Cherry Herb Throat Drops
Sugar Free Lemon Mint Herb Throat Drops
Sugar Free Mountain Herb Cough Suppressant Throat Drops
Sugar Free Original Swiss Herb Cough Suppressant Throat Drops
Sugar Free Refreshing Mint Fishermans Friend Menthol Cough Suppressant
Sugar Free Swiss Cherry Herb Throat Drops
The Medicine Shoppe Extra Strength Pain Relieving
The Original Natural Herb Cough Drops
Therafreeze
Theraid
Therapeutic Relief Preferred Plus Pharmacy
Theraplus Plus
Throat Coat
Tianhe Guben Yaoshen Tie Gao
Top Care Medicated
Topcare Medicated
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
Ultra Strength Stopain Pain Relieving
Us Favorite Cold Pain Relieving
Vaporizing Colds Rub
Vicks Vapodrops Cough Relief
Vitaminerals Inc. Cryogel Natural Pain Relieving
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
Walgreens Aloe Vera Cooling
Watermelon Frost Sore Throat
Wellpatch Backache Pain Relief
Xtracare Ice Cold Topical Analgesic Gel
Youngevity Invision CM
Yun Xiang Jing
ZINC01482164
Zhong Hua Jiu Patch
Zims Arnica Max
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
2Insulin, Globin Zinc4069
3insulin4069

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phenotype and Etiology of Pallister-Hall SyndromeCompletedNCT00001404
2Triphalangeal Thumbs in the Pediatric Population: Long Term Outcomes Following Surgical InterventionCompletedNCT01409980
3Bardet-Biedl Syndrome Study: Clinical and Genetic Epidemiology Study in AdultsCompletedNCT00213811
4Clinical and Molecular Investigations Into CiliopathiesRecruitingNCT00068224
5Genetics and Clinical Characteristics of Bardet-Biedl SyndromeTerminatedNCT00078091

Search NIH Clinical Center for Polydactyly


Cochrane evidence based reviews: Polydactyly

Genetic Tests for Polydactyly

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Anatomical Context for Polydactyly

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MalaCards organs/tissues related to Polydactyly:

33
Bone, Heart, Kidney, Brain, Tongue, Skin, Pituitary

Animal Models for Polydactyly or affiliated genes

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MGI Mouse Phenotypes related to Polydactyly:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.4BBS1, BBS4, GLI3, MKKS, SHH
2MP:00053949.0BBS1, BBS2, BBS4, GLI3, MKKS, SHH
3MP:00053908.3DYNC2H1, EVC, GLI3, LMBR1, NEK1, SHH
4MP:00053678.2BBS1, BBS2, BBS4, DYNC2H1, GLI3, NEK1
5MP:00053818.2BBS2, BBS4, BBS7, DYNC2H1, GLI3, SHH
6MP:00053897.5BBS1, BBS2, BBS4, CCND2, EVC, GLI3
7MP:00053887.5BBS1, BBS4, DYNC2H1, GLI3, MKKS, SHH
8MP:00053787.2BBS1, BBS2, BBS4, EVC, GLI3, LMBR1
9MP:00053857.2BBS1, BBS4, BBS7, CCND2, DYNC2H1, GLI3
10MP:00053917.2BBS1, BBS2, BBS4, BBS7, CCND2, DYNC2H1
11MP:00053827.2BBS1, BBS4, BBS7, DYNC2H1, EVC, GLI3
12MP:00053717.1BBS1, BBS2, BBS7, DYNC2H1, EVC, GLI3
13MP:00036316.3BBS1, BBS2, BBS4, BBS7, CCND2, DYNC2H1
14MP:00107685.6BBS1, BBS4, BBS7, CCND2, DYNC2H1, EVC

Publications for Polydactyly

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Articles related to Polydactyly:

(show top 50)    (show all 621)
idTitleAuthorsYear
1
A Rare Cause of Persistent Pulmonary Hypertension Resistant to Therapy in The Newborn: Short-Rib Polydactyly Syndrome. (26078906)
2015
2
Defining postoperative stability in children with radial polydactyly. (26514392)
2015
3
Autopsy observations in lethal short-rib polydactyly syndromes. (25437139)
2015
4
Polydactyly of the hand. (25950541)
2015
5
An unusual case of radial polydactyly, (tetraplication of the thumb, duplication of the radial carpal bones and bifurcation of the radius). (25664282)
2014
6
Treatment of postaxial polydactyly type B. (23540414)
2013
7
Correction of postaxial metatarsal polydactyly of the foot by percutaneous ray amputation and osteotomy. (23063205)
2013
8
Congenital polydactyly and polymetatarsalia: classification, genetics, and surgical correction. 1981. (21513870)
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9
Prenatal diagnosis of short-rib polydactyly syndrome type 3 (Verma-Naumoff type) by three-dimensional helical computed tomography. (21159031)
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Understanding the molecular basis of polydactyly. (20954615)
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11
Ciliary abnormalities due to defects in the retrograde transport protein DYNC2H1 in short-rib polydactyly syndrome. (19361615)
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12
Polydactyly in mice lacking HDAC9/HDRP. (18480421)
2008
13
Crossed polydactyly prenatally diagnosed by 2- and 3-dimensional sonography. (17384052)
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14
Preaxial polydactyly in neurofibromatosis 1. (17551336)
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15
Short rib-polydactyly syndrome: lethal chondrodysplasia associated with brain malformations in a 35-week-gestation infant. (16719409)
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16
Hemizygosity for chromosome 2q14.2-q22.1 spanning the GLI2 and PROC genes associated with growth hormone deficiency, polydactyly, deep vein thrombosis and urogenital abnormalities. (16650085)
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17
Recurrent short-rib polydactyly syndrome: prenatal three-dimensional ultrasound findings and associations with congenital high airway obstruction and pyelectasia. (15906413)
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Experience with the surgical treatment of radial polydactyly in adults. (16186699)
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19
Megalencephaly and perisylvian polymicrogyria with postaxial polydactyly and hydrocephalus: a rare brain malformation syndrome associated with mental retardation and seizures. (15627943)
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20
A female with complete lack of MA1llerian fusion, postaxial polydactyly, and tetralogy of fallot: genetic heterogeneity of McKusick-Kaufman syndrome or a unique syndrome? (15266619)
2004
21
A 34-week-old male fetus with short rib polydactyly syndrome (SRPS) type I (Saldino-Noonan) with pancreatic cysts. (12921311)
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22
Polydactyly: how many disorders and how many genes? (12357471)
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P2 Developmental mechanisms underlying polydactyly in the mouse mutant, Doublefoot. (17103775)
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Liver fibrocystic disease and polydactyly: proposal of a new syndrome. (11343330)
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Familial torticollis with polydactyly: manifestation in three generations. (11520023)
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26
Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly. (10952899)
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Suppression of polydactyly of the Gli3 mutant (extra toes) by deltaEF1 homozygous mutation. (10969736)
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28
Polydactyly reported by Raphael. (11124206)
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29
Clinical and genetic studies on 12 preaxial polydactyly families and refinement of the localisation of the gene responsible to a 1.9 cM region on chromosome 7q36. (9950363)
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Postaxial polydactyly, ulnar ray dysgenesis, and renal cystic dysplasia in sibs. (10594882)
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Polydactyly and functional psychosis. (10645344)
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Short-rib polydactyly syndrome, Beemer-Langer type, with bilateral huge polycystic renal dysplasia: an autopsy case. (9610623)
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Associated anomalies in individuals with polydactyly. (9880209)
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Transvaginal sonographic diagnosis of short-rib polydactyly dysplasia at 13 weeks' gestation. (9854733)
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Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling. (9671585)
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Urinary hydrocolpos, cloacal malformation and pre-axial polydactyly: a rare variant of neonatal hydrocolpos. (9565227)
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Hand and foot postaxial polydactyly: two different traits. (9375922)
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The atrioventricular canal defect is the congenital heart disease connecting short rib-polydactyly and oral-facial-digital syndromes. (8986290)
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Subclassification of polydactyly. (8733358)
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A new surgical technique for postaxial polydactyly of the foot. (8532771)
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The zig-zag deformity in pre-axial polydactyly. A new cause and its treatment. (7595006)
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On congenital obesity syndrome with polydactyly and retinitis pigmentosa (a contribution to the study of clinical forms of hypophyseal obesity). 1920. (8521156)
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Beemer-Langer type short rib-polydactyly syndrome: report of two cases. (8085456)
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A combination surgical method for preaxial polydactyly of the foot. (8239438)
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Polydactyly of the thumb. (8436855)
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Dysmorphology report: on the association of microcephaly and preaxial polydactyly. Another example of Howard-Young syndrome. (1472358)
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Harlequin fetus with polydactyly and renal dysplasia. (2279815)
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Encephalocele, polycystic kidneys, and polydactyly with other defects. A necropsy case of Meckel syndrome and a review of literature. (3604681)
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Three conditions in neonatal asphyxiating thoracic dysplasia (Jeune) and short rib-polydactyly syndrome spectrum: a clinicopathologic study. (3130854)
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A 63-mm human fetus with radial aplasia, tibial polydactyly, rib and vertebral fusions, and right aortic arch. (4428420)
1974

Variations for Polydactyly

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Expression for genes affiliated with Polydactyly

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Search GEO for disease gene expression data for Polydactyly.

Pathways for genes affiliated with Polydactyly

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GO Terms for genes affiliated with Polydactyly

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Cellular components related to Polydactyly according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1pericentriolar materialGO:000024210.2BBS4, NEK1
2motile ciliumGO:003151410.1BBS2, BBS4, MKKS
3ciliary tipGO:00975429.3DYNC2H1, GLI3, WDR34, WDR35, WDR60
4primary ciliumGO:00723729.3DYNC2H1, GLI3, WDR34, WDR35, WDR60
5BBSomeGO:00344649.1BBS1, BBS2, BBS4, BBS7, TTC8
6ciliary membraneGO:00601708.7BBS1, BBS2, BBS4, BBS7, EVC, TTC8
7axonemeGO:00059308.3BBS1, BBS7, DYNC2H1, GLI3, WDR34, WDR35
8ciliumGO:00059298.1BBS4, EVC, GLI3, TTC8, WDR35, WDR60
9centrosomeGO:00058137.2BBS1, BBS4, BBS7, MKKS, NEK1, TTC8
10ciliary basal bodyGO:00360647.0BBS1, BBS2, BBS4, BBS7, EVC, MKKS
11cytosolGO:00058296.6BBS1, BBS2, BBS4, BBS7, CCND2, DYNC2H1

Biological processes related to Polydactyly according to GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idNameGO IDScoreTop Affiliating Genes
1hindgut morphogenesisGO:000744210.7GLI3, SHH
2negative regulation of alpha-beta T cell differentiationGO:004663910.7GLI3, SHH
3positive regulation of alpha-beta T cell differentiationGO:004663810.6GLI3, SHH
4embryonic morphogenesisGO:004859810.6GLI3, SHH
5anatomical structure developmentGO:004885610.6GLI3, SHH
6artery developmentGO:006084010.6GLI3, SHH
7negative thymic T cell selectionGO:004506010.5GLI3, SHH
8positive regulation of protein import into nucleusGO:004230710.5GLI3, SHH
9artery smooth muscle contractionGO:001482410.5BBS2, MKKS
10dorsal/ventral pattern formationGO:000995310.4DYNC2H1, GLI3, SHH
11negative regulation of actin filament polymerizationGO:003083710.4BBS4, MKKS
12sensory processingGO:005089310.3BBS4, TTC8
13positive regulation of smoothened signaling pathwayGO:004588010.3DYNC2H1, EVC, SHH
14spinal cord motor neuron differentiationGO:002152210.3DYNC2H1, GLI3, SHH
15face developmentGO:006032410.3BBS4, MKKS
16embryonic digit morphogenesisGO:004273310.2GLI3, LMBR1, SHH
17embryonic limb morphogenesisGO:003032610.2DYNC2H1, GLI3, SHH
18pigment granule aggregation in cell centerGO:005187710.1BBS7, MKKS
19striatum developmentGO:002175610.1BBS2, BBS4, MKKS
20leptin-mediated signaling pathwayGO:003321010.1BBS2, BBS4, MKKS
21intraciliary retrograde transportGO:003572110.1DYNC2H1, WDR35
22negative regulation of appetite by leptin-mediated signaling pathwayGO:003810810.1BBS2, BBS4, MKKS
23response to leptinGO:004432110.1BBS2, BBS4, MKKS
24brain morphogenesisGO:004885410.0BBS2, BBS4, MKKS
25regulation of cilium beat frequency involved in ciliary motilityGO:006029610.0BBS2, BBS4, MKKS
26forebrain developmentGO:003090010.0DYNC2H1, GLI3, SHH
27positive regulation of multicellular organism growthGO:00400189.9BBS2, BBS4, MKKS
28negative regulation of GTPase activityGO:00342609.9BBS4, MKKS, TTC8
29regulation of stress fiber assemblyGO:00514929.9BBS4, MKKS, TTC8
30limb developmentGO:00601739.9BBS7, GLI3, SHH
31intracellular transportGO:00469079.7BBS4, BBS7, MKKS
32smoothened signaling pathwayGO:00072249.6BBS7, EVC, GLI3, SHH
33hippocampus developmentGO:00217669.6BBS2, BBS4, GLI3, MKKS
34negative regulation of gene expressionGO:00106299.6BBS2, BBS4, MKKS, SHH
35protein localization to ciliumGO:00615129.6BBS1, BBS4, WDR35
36cartilage developmentGO:00512169.5BBS2, EVC, MKKS
37photoreceptor cell maintenanceGO:00454949.5BBS1, BBS2, BBS4, MKKS
38protein localizationGO:00081049.5BBS2, BBS4, BBS7
39melanosome transportGO:00324029.5BBS2, BBS4, BBS7, MKKS
40heart loopingGO:00019479.5BBS4, BBS7, MKKS, SHH
41palate developmentGO:00600219.4BBS7, GLI3, SHH
42cerebral cortex developmentGO:00219879.2BBS2, BBS4, MKKS
43cilium morphogenesisGO:00602719.2BBS2, BBS4, BBS7, DYNC2H1, MKKS
44fat cell differentiationGO:00454449.0BBS2, BBS4, BBS7, MKKS, TTC8
45determination of left/right symmetryGO:00073689.0BBS7, DYNC2H1, MKKS, SHH
46heart developmentGO:00075078.9BBS7, GLI3, MKKS, SHH
47visual perceptionGO:00076018.7BBS1, BBS2, BBS4, BBS7, MKKS
48nonmotile primary cilium assemblyGO:00350588.6BBS1, BBS2, BBS4, BBS7, MKKS, TTC8
49cilium assemblyGO:00423846.9BBS1, BBS2, BBS4, BBS7, DYNC2H1, MKKS
50organelle organizationGO:00069966.7BBS1, BBS2, BBS4, BBS7, DYNC2H1, LZTFL1

Molecular functions related to Polydactyly according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1patched bindingGO:000511310.0BBS1, SHH
2RNA polymerase II repressing transcription factor bindingGO:00011038.1BBS1, BBS2, BBS4, BBS7, MKKS, TTC8

Sources for Polydactyly

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet