MCID: PLY006
MIFTS: 54

Polydactyly malady

Categories: Rare diseases, Bone diseases, Fetal diseases

Aliases & Classifications for Polydactyly

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Aliases & Descriptions for Polydactyly:

Name: Polydactyly 10 45 47 12 36 24
Polydactyly, Postaxial 47 24 65
Postaxial Polydactyly 10
Supernumerary Digits 45
Supernumerary Digit 10
 
Polydactylism 45
Polydactylia 45
Extra Digits 45
Hyperdactyly 45

Classifications:



External Ids:

Disease Ontology10 DOID:1148
ICD1027 Q69, Q69.9
ICD9CM29 755.0, 755.00
NCIt42 C87110
UMLS65 C0152427, C0220697

Summaries for Polydactyly

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NIH Rare Diseases:45 Polydactyly is a condition in which a person has more than five fingers per hand or five toes per foot. it is the most common birth defect of the hand and foot. polydactyly can occur as an isolated finding such that the person has no other physical anomalies or intellectual impairment. however, it can occur in association with other birth defects and cognitive abnormalities as part of a genetic syndrome. in some cases, the extra digits may be well-formed and functional. surgery may be considered especially for poorly formed digits or very large extra digits. surgical management depends greatly on the complexity of the deformity. last updated: 5/8/2015

MalaCards based summary: Polydactyly, also known as polydactyly, postaxial, is related to polydactyly, preaxial type ii and polydactyly of an index finger, unilateral. An important gene associated with Polydactyly is GLI3 (GLI Family Zinc Finger 3), and among its related pathways are Intraflagellar transport and Signaling by Hedgehog. Affiliated tissues include heart, bone and pituitary, and related mouse phenotypes are hearing/vestibular/ear and digestive/alimentary.

Wikipedia:68 Polydactyly or polydactylism (from Greek πολύς (polys), meaning \"many\", and δάκτυλος... more...

Related Diseases for Polydactyly

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Diseases in the Polydactyly family:

Central Polydactyly of Toes

Diseases related to Polydactyly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1polydactyly, preaxial type ii33.7LMBR1, SHH
2polydactyly of an index finger, unilateral33.6LMBR1, SHH
3hypoplastic or aplastic tibia with polydactyly33.5LMBR1, SHH
4postaxial polydactyly type a, unilateral33.5LMBR1, SHH
5polydactyly, preaxial, type iv32.7GLI3, MKKS, SHH
6syndactyly, type iv30.3LMBR1, SHH
7weyers acrofacial dysostosis29.4DYNC2H1, EVC, NEK1, WDR35
8bardet-biedl syndrome 329.0BBS1, BBS2
9bardet-biedl syndrome 627.2BBS1, BBS2, BBS4, BBS7, GLI3, MKKS
10obesity26.4BBS1, BBS2, BBS4, BBS7, MKKS, TTC8
11short-rib thoracic dysplasia 3 with or without polydactyly12.2
12polydactyly, postaxial, types a1 and b12.1
13short-rib thoracic dysplasia 6 with or without polydactyly12.1
14preaxial polydactyly type 112.1
15short-rib thoracic dysplasia 7 with or without polydactyly12.0
16short-rib thoracic dysplasia 8 with or without polydactyly12.0
17megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 111.9
18preaxial polydactyly type 311.9
19megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 211.9
20polydactyly myopia syndrome11.9
21dandy-walker malformation with postaxial polydactyly11.9
22short-rib thoracic dysplasia 10 with or without polydactyly11.9
23short-rib thoracic dysplasia 11 with or without polydactyly11.9
24megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 311.9
25postaxial polydactyly type b11.9
26polydactyly, postaxial, type a611.9
27short-rib thoracic dysplasia 14 with polydactyly11.9
28short-rib thoracic dysplasia 4 with or without polydactyly11.9
29short-rib thoracic dysplasia 5 with or without polydactyly11.9
30short-rib thoracic dysplasia 13 with or without polydactyly11.9
31clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly11.9
32central polydactyly of toes11.9
33central polydactyly of fingers11.9
34short-rib thoracic dysplasia 2 with or without polydactyly11.8
35short-rib thoracic dysplasia 9 with or without polydactyly11.8
36postaxial polydactyly of toes11.8
37preaxial polydactyly of toes11.8
38polydactyly of a biphalangeal thumb, unilateral11.8
39polydactyly of a biphalangeal thumb, bilateral11.8
40polydactyly of a triphalangeal thumb, unilateral11.8
41polydactyly of a triphalangeal thumb, bilateral11.8
42polydactyly of an index finger, bilateral11.8
43central polydactyly of fingers, unilateral11.8
44central polydactyly of fingers, bilateral11.8
45central polydactyly of toes, bilateral11.8
46central polydactyly of toes, unilateral11.8
47postaxial polydactyly, type a211.8
48brachyphalangy, polydactyly, and tibial aplasia/hypoplasia11.8
49short-rib thoracic dysplasia 1 with or without polydactyly11.8
50postaxial polydactyly type b, bilateral11.8

Graphical network of the top 20 diseases related to Polydactyly:



Diseases related to polydactyly

Symptoms for Polydactyly

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Drugs & Therapeutics for Polydactyly

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Drugs for Polydactyly (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Mentholapproved19992216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
999 Itch Relief
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
Absorbine Back Therapeutic Pain Relief
Absorbine Jr
Absorbine Jr Ultra Strength Pain Relieving
Absorbine Jr.
Absorbine Jr. Back
Algomend Pain Relief
Alhua Huogan Pain Relieving Patch
Aloemint Skin Aid
Amar Ice
Analgesic
Anc Neverpain External Analgesic
Anti Itch
Army Health Pain Reliever
Arthri-support
Arthri-zen Relief
Arthripain Relief
Arthritis Relief
Aspercreme Heat
Aspercreme Max No Mess Roll On
Assured Cold N Hot Pain Relief Menthol
Assured Extra Strength Cold N Hot
Assured Ice Cold Topical Analgesic
Assured Muscle Rub
Assured Pain Relief Hot Menthol
Atopalm Pain Relieving
Aurorae Healing Pain Relieving Roll-on
Avapta
Avedana Pain Relieving Roll On
Avedana Pain-relieving
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
Babyganics Cold Relief Chest Rub
Barox
Barox BODY CARE MASSAGE
Barox Body Care Massage Relax Refresh Revital
Being Well Extra Strength Menthol Heat
Bengay Ultra Strength Large Size
Bengay Ultra Strength Pain Relieving Large Size
Bengay Ultra Strength Pain Relieving Regular Size
Bengay Ultra Strength Regular Size
Bengay Vanishing Scent
Bengay Zero Degrees Menthol Pain Relieving
Bentasil SUGAR FREE BLACKCURRANT SOFT Texture
Bentasil SUGAR FREE CHERRY SOFT Texture
Bentasil SUGAR FREE HONEY LEMON SOFT Texture
Berri-freez
Besthealth Cherry
Besthealth Cough Suppressant Sugar Free Black Cherry Flavor
Besthealth Cough Suppressant Sugar Free Honey Lemon Flavor
Besthealth Honey Lemon
Besthealth Menthol
Bio 2 Brazilian Heat Brazilian Heat
Bio-scriptives Extreme Pr
Bioblast Pain Relief
Bioflexor
Biofreeze
Biofreeze Colorless
Biofreeze Colorless Roll-on
Biofreeze Roll-on
Biorelief Ice Pain Relieving
Blistex Ivarest Medicated Poison Ivy Cleansing Foam
Blue Gel Pain Relieving
Blue Ice
Blue Ice Analgesic
Blue Ice Analgesic Gel
Blue Ice Pain Relieving
Body
Budpack Muscle Rub
Budpak Muscle Rub
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Canker Complete Canker Sore Relief
Caswell No. 540
Celadrin
Cepacol Sore Throat From Post Nasal Drip
Cepacol Sore Throat Regular Strength
Ching Wan Hung Soothing Herbal Balm
Choice Personal Care Theraputic Blue Ice
Cold Hot Patch
Cold Spot Point Relief
Coldaid
Cool N Heat Patch For Back Extra Strength
Coralite Extra Strength Menthol Pain Relief Sleeve - Knee
Coralite Extra Strength Menthol Pain Relief Sleeve - Wrist
Coralite Pain Relief
Counteract Cough Drops Honey Lemon
Counteract Cough Drops Orchard Cherry
Cryogel Island Rain Natural Pain Relieving Vitaminerals
Cvs Cold Hot Medicated
Cvs Soothing Itch Relief
Cvs Sore Muscle Rub Vanishing Scent
Cvs Therapeutic Menthol Gel
Cvs Therapeutic Menthol Pain Reliever
Cvs Tropical Citrus Cough
Cvs Ultra Strength Pain Relieving
Cvs Vanishing Scent Muscle Rub
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
Dg Health Extra Strength Medicated
Dg Health Pain Relieving
Dg Ice Cold Analgesic
Diapedic Foot Treatment
DivK1c_000820
Dorflex Icy Hot Flexible, Large
Dorflex Icy Hot Flexible, Small
Dorflex Icy Hot Flexible, XL
Dr. Blue
Dt Ice Cold Analgesic
Dual Action Cherry Cough Suppressant Oral Anesthetic
Dynafreeze
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
Easy
Eb301ap Pain Relief
Eb301ct Bruise Pain Relief
Eb302 Arthritis Relief
Ecolyptus Pain Relieving Muscle Rub
Efac Pain Relieving
Elgin Pain Relief
Equaline Blue Ice Pain Relieving
Equate Menthol Extra Strength
Eros Iron Man
Eucalyptamint
Eucerin Calming Itch Relief Treatment
Extra Strength Cold N Hot Pain Relief Medicated
Extra Strength Pain Relief Therapy
Extra Strength Stopain Cold Pain Relieving
Extra Strength Stopain Cold Pain Relieving Roll On
FEMA No. 2665
Family Care Maximum Strength Medicated Anti Itch
Fast Freeze
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
Flexall Pain Relieving
Flexgen
Fluaid
Foot Works Achy Foot Massager Pain Relieving
Gold Bond Foot Extra Strength
Gold Bond Medicated Foot
Gold Bond Pain Relieving Foot
Gold Bond Pain Relieving Foot Roll On
Green Bamboo
Green Guard Cough Drop Relief
HMS1922G13
HMS2092L14
HMS502I22
HSDB 5662
HSDB 593
Halls Apple Cider
Halls Butterscotch
Halls Cherry
Halls Extra Strong Menthol
Halls Honey Lemon
Halls Ice Peppermint
Halls MENTHO-LYPTUS
Halls Melon Splash
Halls Menthol
Halls Mentholyptus
Halls Mocha Mint
Halls Naturals Honey Lemon Chamomile
Halls Plus Cherry
Halls Plus Honey
Halls Plus Strawberry
Halls Spearmint
Halls Strawberry
Halls Sugar Free Black Cherry
Halls Sugar Free Citrus Blend
Halls Sugar Free Extra Strong Menthol
Halls Sugar Free Honey Berry
Halls Sugar Free Honey Lemon
Halls Sugar Free Mountain Menthol
Halls Tropical Fruit
Hallsmelon Splash Melon Splash
Hallssugar Free Extra Sugar Free Extra Strong Menthol
Han Honey Loquat Syrup
Hanbang Cataplasma
Harmon Extra Strength Pain Relieving
Harmon Extra Strength Pain Relieving Roll-on
Headache crystals
Health Smart Medicated Foot
Herbion Naturals Honey Lemon
Herbion Naturals Honey Lemon Cough Drops
Herbion Naturals Honey-Lemon Cough Drops
Herbion Naturals Mint Cough Drops
Herbion Naturals Orange
Herbion Naturals Orange Cough Drops
Hexahydrothymol
Hielo Ardiente
Honibe
 
Hot Ice Soothing Analgesic Gel
Huitomi Slimming Sports
Humphreys Bendito Alcoholado
I06-1216
I14-7371
IDI1_000820
Ice
Ice Cold Analgesic
Ice Cold Topical Analgesic Gel
Ice External Analgesic Leader
Ice Quake
Ice Quake Muscle Rub
Icy Cool Maximum Strength
Icy Hot
Icy Hot Back
Icy Hot Medicated
Icy Hot Medicated No Mess Applicator
Icy Hot Medicated Roll Large
Icy Hot Medicated Roll Medium
Icy Hot Medicated Roll, Large
Icy Hot Medicated Roll, Medium
Icy Hot Medicated, Advanced Relief
Icy Hot Medicated, Back
Icy Hot Medicated, XL
Icy Hot Naturals
Icy Hot Power Gel
Icy Hot Vanishing Scent
Icyhot Medicated
Imada Four Seasons Safe Analgesic Balm
Jakemans Blueberry
Jakemans Cherry
Jakemans Peppermint
K2 Cold Therapy
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
Kay Medic Menthol Pain Relief
Kool Comfort
Kool Comfort Pain Relieving Roll-on
Kpp Triple Action
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
La Jiao Feng Shi Gao
Lander Polar Ice
Leader Cough Drops Cherry Flavor
Leader Cough Drops Honey Lemon
Leader Cough Drops Menthol Flavor
Leader Extra Strength Medicated Pain Relief Patch
Leader Sugar Free Cough Drops Black Cherry
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
Linkus Lozenges Cough Suppressant/Oral Anesthetic
Low Sugar Cherry Flavor Fishermans Friend Menthol Cough Suppressant
Ludens Honey Lemon Throat Drops
Ludens Honey Licorice Throat Drops
Ludens Original Menthol Throat Drops
Lurosil
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Makesense Extra Strength Muscle Rub
Maxfit Freeze Gel
Maybelline New York Baby Lips Dr Rescue Medicated Balm
Medi First Plus Cherry Cough Drops
Medi-first Cherry Cough Drops
Medic Ice
Medicated Body Powder
Medicated Pain Relief
Mediflex
Medique Medikoff Drops
Medique Sugar Free Medikoff Drops
Meditowel PAIN RELIEF
Meijer Cherry Cough Drops
Meijer Honey Lemon Cough Drops
Meijer Menthol Cough Drops
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol Fresh Cough Suppressant
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Mentholatum Pain Relief Extra Strength
Mentholatum Sports Pain Relief Cold
Menthomenthol
Menthyl alcohol
Mineral Ice Pain Relieving
Miracle Foot Repair
Miracle Foot Repair Cream
Miracle Of Aloe Rub Roll On
Miracle Pain Cream
Moisture Therapy Anti-Itch
MolPort-000-849-729
MolPort-001-793-392
Moore Medical Cherry Cough Suppressant/anesthetic Drops
Moore Medical Sugar Free Black Cherry Cough Suppressant/anesthetic Drops
Moore Medical Sugar Free Menthol Cough Suppressant/anesthetic Drops
Mr Dudleys Topical Pain Relief
Muscle
Muscle Rub Ultra Strength Pain Relieving
Myo-breathe
Myorx Low Dose Pain Relieving
Myorx Pain Relieving
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Nan San Easy Flex Pain Relieving
Natural Cherry Honey Herb Throat Drops
Natural Herb cough drop
Natural Honey Herb Cough Suppressant Throat Drops
Natural Lemon Mint Herb Throat Drops
Natural Pain Relieving Lavender Breeze Cryogel
Natures Choice Cool Hot Ice
Natures Sunshine Products Everflex Topical Analgesic Pain Relief
Neoisomenthol
Nice Assorted
Nice Cherry
Nice Citrus
Nice Cool Mint
Nice Honey Lemon
Nice Menthol
No Pain More Gain
North Cough Drop
Numotizine
Olbas Lozenges Maximun Strength
Olbas Pastilles
Original Extra Strong All Natural Fishermans Friend Menthol Cough Suppressant
Ortho-nesic
Osmoflex
Oxyrub Pain Relief
Pain Relief Balmpreferred Plus Ph Preferred Plus Pharmacy
Pain Relief Therapy Patch
Pain Reliever
Pain Relieving
Pain Relieving Analgesic
Pain Relieving Patch
Pain Relieving Patch Ultra Strength
Pain Relieving Patch Ultra Strength ULTRA STRENGTH
Panitrol XR
Paraid Extra Strength Menthol Pain Relief Sleeve Knee Large Ankles Elbows
Patch Scherer Labs
Patch Walgreens
Peppermint camphor
Perfect Purity Hotice
Perfect Purity Medicated Foot Powder
Perform
Personal Care Extra Strength Cold Hot
Personal Care Ice Cold
Plaster MandAHerbalPlaster
Po Sum On Medicated
Polar Frost Cold
Power Relief
Preferred Plus Body Powder
Premier Value Medicated Foot Powder
Q Health Pain Relief Spray
Quickflex
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Raw Heat
Raw Ice
Reactice Reactivating Ice Baume
Red Lion Relief
Relief Pain Relieving Cream
Rexall Vanishing Scent Pain Relieving
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Screamin Menthol Toast
Sella Natural
Skin So Soft Bug Guard Plusitch Relief itch relief
Smith Bros Honey Lemon Cough Drops
Smith Bros Menthol Eucalyptus Cough Drops
Smith Bros Sugar-free Black Cherry Cough Drops
Sof Skin Icy Blue
Sofskin Ice Analgesic
Sombra Cool Therapy
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Stopain Cold Pain Relieving
Stopain Cold Professional Strength Pain Relieving
Stopain Extra Strength Pain Relieving
Sub-zero COOL PAIN RELIEVING
Sugar Free Cherry Fishermans Friend Menthol Cough Suppressant
Sugar Free Cherry Herb Throat Drops
Sugar Free Lemon Mint Herb Throat Drops
Sugar Free Mountain Herb Cough Suppressant Throat Drops
Sugar Free Original Swiss Herb Cough Suppressant Throat Drops
Sugar Free Refreshing Mint Fishermans Friend Menthol Cough Suppressant
Sugar Free Swiss Cherry Herb Throat Drops
The Medicine Shoppe Extra Strength Pain Relieving
The Original Natural Herb Cough Drops
Therafreeze
Theraid
Therapeutic Relief Preferred Plus Pharmacy
Theraplus Plus
Throat Coat
Tianhe Guben Yaoshen Tie Gao
Top Care Medicated
Topcare Medicated
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
Ultra Strength Stopain Pain Relieving
Us Favorite Cold Pain Relieving
Vaporizing Colds Rub
Vicks Vapodrops Cough Relief
Vitaminerals Inc. Cryogel Natural Pain Relieving
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
Walgreens Aloe Vera Cooling
Watermelon Frost Sore Throat
Wellpatch Backache Pain Relief
Xtracare Ice Cold Topical Analgesic Gel
Youngevity Invision CM
Yun Xiang Jing
ZINC01482164
Zhong Hua Jiu Patch
Zims Arnica Max
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
2Liver Extracts3572
3Insulin, Globin Zinc4278
4insulin4278

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phenotype and Etiology of Pallister-Hall SyndromeCompletedNCT00001404
2Triphalangeal Thumbs in the Pediatric Population: Long Term Outcomes Following Surgical InterventionCompletedNCT01409980
3Bardet-Biedl Syndrome Study: Clinical and Genetic Epidemiology Study in AdultsCompletedNCT00213811
4Clinical and Molecular Investigations Into CiliopathiesRecruitingNCT00068224
5Genetics and Clinical Characteristics of Bardet-Biedl SyndromeTerminatedNCT00078091

Search NIH Clinical Center for Polydactyly


Cochrane evidence based reviews: polydactyly

Genetic Tests for Polydactyly

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Anatomical Context for Polydactyly

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MalaCards organs/tissues related to Polydactyly:

33
Heart, Bone, Pituitary, Thyroid, Brain, T cells, Prostate

Animal Models for Polydactyly or affiliated genes

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MGI Mouse Phenotypes related to Polydactyly:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.0BBS1, BBS4, GLI3, MKKS, SHH
2MP:00053818.1BBS2, BBS4, BBS7, DYNC2H1, GLI3, SHH
3MP:00053948.0BBS1, BBS2, BBS4, BBS7, GLI3, MKKS
4MP:00053887.8BBS1, BBS4, DYNC2H1, GLI3, MKKS, SHH
5MP:00053677.5BBS1, BBS2, BBS4, BBS7, DYNC2H1, GLI3
6MP:00053897.3BBS1, BBS2, BBS4, BBS7, CCND2, EVC
7MP:00053917.2BBS1, BBS2, BBS4, BBS7, CCND2, DYNC2H1
8MP:00053717.1BBS1, BBS2, BBS7, DYNC2H1, EVC, GLI3
9MP:00053826.9BBS1, BBS4, BBS7, DYNC2H1, EVC, GLI3
10MP:00053856.7BBS1, BBS4, BBS7, CCND2, DYNC2H1, GLI3
11MP:00036316.6BBS1, BBS2, BBS4, BBS7, CCND2, DYNC2H1
12MP:00053846.5BBS1, BBS2, BBS4, BBS7, DYNC2H1, EVC
13MP:00053786.2BBS1, BBS2, BBS4, BBS7, DYNC2H1, EVC
14MP:00107685.4BBS1, BBS4, BBS7, CCND2, DYNC2H1, EVC

Publications for Polydactyly

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Articles related to Polydactyly:

(show top 50)    (show all 646)
idTitleAuthorsYear
1
Parallel Evolution of Polydactyly Traits in Chinese and European Chickens. (26859147)
2016
2
Polydactyly: A Review. (27194607)
2016
3
Exome sequencing identifies a mutation in OFD1 in a male with Joubert syndrome, orofaciodigital spectrum anomalies and complex polydactyly. (27081566)
2016
4
A Rare Cause of Persistent Pulmonary Hypertension Resistant to Therapy in The Newborn: Short-Rib Polydactyly Syndrome. (26078906)
2015
5
Defining postoperative stability in children with radial polydactyly. (26514392)
2015
6
Autopsy observations in lethal short-rib polydactyly syndromes. (25437139)
2015
7
Polydactyly of the hand. (25950541)
2015
8
An unusual case of radial polydactyly, (tetraplication of the thumb, duplication of the radial carpal bones and bifurcation of the radius). (25664282)
2014
9
Treatment of postaxial polydactyly type B. (23540414)
2013
10
Correction of postaxial metatarsal polydactyly of the foot by percutaneous ray amputation and osteotomy. (23063205)
2013
11
Congenital polydactyly and polymetatarsalia: classification, genetics, and surgical correction. 1981. (21513870)
2011
12
Prenatal diagnosis of short-rib polydactyly syndrome type 3 (Verma-Naumoff type) by three-dimensional helical computed tomography. (21159031)
2011
13
Understanding the molecular basis of polydactyly. (20954615)
2010
14
Ciliary abnormalities due to defects in the retrograde transport protein DYNC2H1 in short-rib polydactyly syndrome. (19361615)
2009
15
Polydactyly in mice lacking HDAC9/HDRP. (18480421)
2008
16
Crossed polydactyly prenatally diagnosed by 2- and 3-dimensional sonography. (17384052)
2007
17
Preaxial polydactyly in neurofibromatosis 1. (17551336)
2007
18
Short rib-polydactyly syndrome: lethal chondrodysplasia associated with brain malformations in a 35-week-gestation infant. (16719409)
2006
19
Hemizygosity for chromosome 2q14.2-q22.1 spanning the GLI2 and PROC genes associated with growth hormone deficiency, polydactyly, deep vein thrombosis and urogenital abnormalities. (16650085)
2006
20
Recurrent short-rib polydactyly syndrome: prenatal three-dimensional ultrasound findings and associations with congenital high airway obstruction and pyelectasia. (15906413)
2005
21
Megalencephaly and perisylvian polymicrogyria with postaxial polydactyly and hydrocephalus: a rare brain malformation syndrome associated with mental retardation and seizures. (15627943)
2004
22
A female with complete lack of MA1llerian fusion, postaxial polydactyly, and tetralogy of fallot: genetic heterogeneity of McKusick-Kaufman syndrome or a unique syndrome? (15266619)
2004
23
A 34-week-old male fetus with short rib polydactyly syndrome (SRPS) type I (Saldino-Noonan) with pancreatic cysts. (12921311)
2003
24
Polydactyly: how many disorders and how many genes? (12357471)
2002
25
P2 Developmental mechanisms underlying polydactyly in the mouse mutant, Doublefoot. (17103775)
2002
26
Liver fibrocystic disease and polydactyly: proposal of a new syndrome. (11343330)
2001
27
Familial torticollis with polydactyly: manifestation in three generations. (11520023)
2001
28
Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly. (10952899)
2000
29
Suppression of polydactyly of the Gli3 mutant (extra toes) by deltaEF1 homozygous mutation. (10969736)
2000
30
Polydactyly reported by Raphael. (11124206)
2000
31
Clinical and genetic studies on 12 preaxial polydactyly families and refinement of the localisation of the gene responsible to a 1.9 cM region on chromosome 7q36. (9950363)
1999
32
Postaxial polydactyly, ulnar ray dysgenesis, and renal cystic dysplasia in sibs. (10594882)
1999
33
Polydactyly and functional psychosis. (10645344)
1999
34
Short-rib polydactyly syndrome, Beemer-Langer type, with bilateral huge polycystic renal dysplasia: an autopsy case. (9610623)
1998
35
Associated anomalies in individuals with polydactyly. (9880209)
1998
36
Transvaginal sonographic diagnosis of short-rib polydactyly dysplasia at 13 weeks' gestation. (9854733)
1998
37
Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling. (9671585)
1998
38
Urinary hydrocolpos, cloacal malformation and pre-axial polydactyly: a rare variant of neonatal hydrocolpos. (9565227)
1998
39
Hand and foot postaxial polydactyly: two different traits. (9375922)
1997
40
Subclassification of polydactyly. (8733358)
1996
41
A new surgical technique for postaxial polydactyly of the foot. (8532771)
1996
42
The zig-zag deformity in pre-axial polydactyly. A new cause and its treatment. (7595006)
1995
43
On congenital obesity syndrome with polydactyly and retinitis pigmentosa (a contribution to the study of clinical forms of hypophyseal obesity). 1920. (8521156)
1995
44
Beemer-Langer type short rib-polydactyly syndrome: report of two cases. (8085456)
1994
45
A combination surgical method for preaxial polydactyly of the foot. (8239438)
1993
46
Dysmorphology report: on the association of microcephaly and preaxial polydactyly. Another example of Howard-Young syndrome. (1472358)
1992
47
Encephalocele, polycystic kidneys, and polydactyly with other defects. A necropsy case of Meckel syndrome and a review of literature. (3604681)
1987
48
Three conditions in neonatal asphyxiating thoracic dysplasia (Jeune) and short rib-polydactyly syndrome spectrum: a clinicopathologic study. (3130854)
1987
49
A 63-mm human fetus with radial aplasia, tibial polydactyly, rib and vertebral fusions, and right aortic arch. (4428420)
1974
50

Variations for Polydactyly

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Expression for genes affiliated with Polydactyly

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Search GEO for disease gene expression data for Polydactyly.

Pathways for genes affiliated with Polydactyly

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GO Terms for genes affiliated with Polydactyly

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Cellular components related to Polydactyly according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonemeGO:000593010.1BBS1, GLI3
2BBSomeGO:00344649.8BBS1, BBS7
3photoreceptor connecting ciliumGO:00323919.8BBS4, TTC8
4ciliary basal bodyGO:00360648.9BBS2, EVC, MKKS, WDR34
5ciliary tipGO:00975428.7DYNC2H1, WDR34, WDR35, WDR60

Biological processes related to Polydactyly according to GeneCards Suite gene sharing:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of alpha-beta T cell differentiationGO:004663910.7GLI3, SHH
2embryonic morphogenesisGO:004859810.6GLI3, SHH
3negative thymic T cell selectionGO:004506010.6GLI3, SHH
4T cell differentiation in thymusGO:003307710.5GLI3, SHH
5artery developmentGO:006084010.5GLI3, SHH
6photoreceptor cell maintenanceGO:004549410.5BBS2, BBS4
7neuron fate commitmentGO:004866310.5GLI3, SHH
8embryonic digestive tract morphogenesisGO:004855710.5GLI3, SHH
9protein localization to organelleGO:003336510.5BBS2, BBS4
10developmental growthGO:004858910.5GLI3, SHH
11dorsal/ventral pattern formationGO:000995310.5DYNC2H1, SHH
12positive regulation of protein import into nucleusGO:004230710.4GLI3, SHH
13Golgi to plasma membrane protein transportGO:004300110.4BBS1, BBS2
14adult behaviorGO:003053410.4BBS2, BBS4
15artery smooth muscle contractionGO:001482410.4BBS2, MKKS
16negative regulation of actin filament polymerizationGO:003083710.4BBS4, MKKS
17retina homeostasisGO:000189510.4BBS1, BBS4
18metanephros developmentGO:000165610.4GLI3, SHH
19brain morphogenesisGO:004885410.3BBS2, BBS4
20inner ear developmentGO:004883910.3GLI3, SHH
21branching morphogenesis of an epithelial tubeGO:004875410.3GLI3, SHH
22leptin-mediated signaling pathwayGO:003321010.2BBS2, BBS4, MKKS
23pigment granule aggregation in cell centerGO:005187710.0BBS7, MKKS
24positive regulation of neuroblast proliferationGO:000205210.0GLI3, SHH
25heart loopingGO:000194710.0BBS4, MKKS, SHH
26anatomical structure formation involved in morphogenesisGO:00486469.9GLI3, SHH
27limb developmentGO:00601739.9BBS7, GLI3, SHH
28positive regulation of smoothened signaling pathwayGO:00458809.9DYNC2H1, EVC, SHH
29regulation of stress fiber assemblyGO:00514929.9BBS4, MKKS, TTC8
30smoothened signaling pathwayGO:00072249.8BBS7, GLI3, SHH
31melanosome transportGO:00324029.8BBS2, BBS7, MKKS
32cerebral cortex developmentGO:00219879.8BBS2, BBS4, MKKS
33intracellular transportGO:00469079.8BBS4, BBS7, MKKS
34heart developmentGO:00075079.7BBS7, GLI3, SHH
35sensory perception of smellGO:00076089.7BBS4, MKKS, TTC8
36cilium morphogenesisGO:00602719.5BBS2, BBS7, MKKS
37embryonic limb morphogenesisGO:00303269.5DYNC2H1, GLI3, SHH
38negative regulation of gene expressionGO:00106299.5BBS2, BBS4, MKKS, SHH
39cilium assemblyGO:00423849.5BBS2, BBS4, DYNC2H1, MKKS
40hippocampus developmentGO:00217669.5BBS2, BBS4, GLI3, MKKS
41nonmotile primary cilium assemblyGO:00350589.4BBS2, BBS4, BBS7, MKKS
42determination of left/right symmetryGO:00073689.4BBS7, DYNC2H1, MKKS, SHH
43visual perceptionGO:00076018.6BBS1, BBS2, BBS4, BBS7, MKKS

Sources for Polydactyly

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet