MCID: PLY036
MIFTS: 29

Polyembryoma malady

Categories: Rare diseases

Aliases & Classifications for Polyembryoma

Aliases & Descriptions for Polyembryoma:

Name: Polyembryoma 50 56 69
Gonadal Polyembryoma 50 69

Classifications:



External Ids:

Orphanet 56 ORPHA180229
UMLS via Orphanet 70 C0334518

Summaries for Polyembryoma

NIH Rare Diseases : 50 polyembryoma is a type of tumor that develops from the cells of the gonads (testes in men or ovaries in women).  such tumors are called germ cell tumors.  polyembryomas have a distinctive look because they are composed of many parts that are shaped like embryos, one of the earliest stages of a developing human during pregnancy.  symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain in some individuals; puberty at an unusually young age (known as precocious puberty); or irregularities in a female's menstruation.  treatment begins with surgery and may be followed by chemotherapy and/or radiation therapy.  the cause of polyembryoma is not yet known. last updated: 3/20/2012

MalaCards based summary : Polyembryoma, also known as gonadal polyembryoma, is related to testis polyembryoma and polyembryoma of the ovary. An important gene associated with Polyembryoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Glucocorticoid receptor regulatory network. The drugs Palivizumab and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and testis.

Wikipedia : 71 Polyembryoma is a rare, very aggressive form of germ cell tumor usually found in the ovaries.... more...

Related Diseases for Polyembryoma

Diseases related to Polyembryoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
id Related Disease Score Top Affiliating Genes
1 testis polyembryoma 11.8
2 polyembryoma of the ovary 11.8
3 mixed germ cell tumor 10.2
4 rete testis adenoma 10.1 AFP SERPINA1
5 adult botryoid rhabdomyosarcoma 10.0 AFP SERPINA1
6 klinefelter's syndrome 10.0 AFP SERPINA1
7 testicular trophoblastic tumor 10.0 AFP SERPINA1
8 retroperitoneal hemangiopericytoma 10.0 AFP SERPINA1
9 submucosal invasive colon adenocarcinoma 10.0 AFP SERPINA1
10 cellular ependymoma 10.0 AFP SERPINA1
11 hair follicle neoplasm 10.0 AFP SERPINA1
12 hemolytic-uremic syndrome 10.0 AFP SERPINA1
13 focal epithelial hyperplasia 10.0 AFP SERPINA1
14 noninfectious dermatoses of eyelid 10.0 AFP SERPINA1
15 renal pelvis transitional cell carcinoma 9.9 AFP CGA
16 true unicornuate uterus 9.9 AFP CGA
17 severe combined immunodeficiency 9.9 AFP CGA
18 trypanosomiasis, human east-african 9.9 AFP CGA
19 chromosome 11q duplication 9.9 AFP CGA
20 teratoma 9.9
21 malignant teratocarcinosarcoma 9.9 AFP CGA
22 lymph node disease 9.9 AFP CGA
23 ophthalmoplegia, progressive, with scrotal tongue and mental deficiency 9.9 AFP CGA
24 lymphoid leukemia 9.9 AFP SERPINA1
25 childhood malignant hemangiopericytoma 9.9 AFP SERPINA1
26 atopic dermatitis 9.9 AFP CGA
27 breast myoepithelial neoplasm 9.9 AFP CGA
28 hereditary renal cell carcinoma 9.8 AFP CGA
29 diabetes mellitus, insulin-resistant, with acanthosis nigricans 9.8 AFP CGA
30 lymphoblastic lymphoma 9.8 AFP SERPINA1
31 choriocarcinoma 9.8
32 mediastinitis 9.8
33 pontine hemorrhage 9.7 AFP CGA SERPINA1

Graphical network of the top 20 diseases related to Polyembryoma:



Diseases related to Polyembryoma

Symptoms & Phenotypes for Polyembryoma

Drugs & Therapeutics for Polyembryoma

Drugs for Polyembryoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palivizumab Approved, Investigational Phase 3 188039-54-5
2
Ribavirin Approved Phase 3 36791-04-5 37542
3
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
4
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6
Captopril Approved Phase 3 62571-86-2 44093
7
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
8
Fluconazole Approved Phase 3 86386-73-4 3365
9
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
10 Antibodies Phase 3,Phase 1
11 Antibodies, Monoclonal Phase 3,Phase 1
12 Anti-Infective Agents Phase 3,Phase 2
13 Antimetabolites Phase 3
14 Antiviral Agents Phase 3,Phase 2
15 Immunoglobulins Phase 3,Phase 1
16 Anti-Bacterial Agents Phase 3
17 Antifungal Agents Phase 3
18 Antiparasitic Agents Phase 3
19 Antiprotozoal Agents Phase 3
20 Echinocandins Phase 3
21 Liposomal amphotericin B Phase 3
22 Alkylating Agents Phase 3,Phase 2
23 Angiotensin-Converting Enzyme Inhibitors Phase 3
24 Antihypertensive Agents Phase 3
25 Antineoplastic Agents, Alkylating Phase 3,Phase 2
26 Antirheumatic Agents Phase 3
27 HIV Protease Inhibitors Phase 3
28 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
29
protease inhibitors Phase 3
30 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
31 Cytochrome P-450 CYP3A Inhibitors Phase 3
32 Cytochrome P-450 Enzyme Inhibitors Phase 3
33 Hormone Antagonists Phase 3,Phase 1,Phase 2
34 Hormones Phase 3,Phase 1,Phase 2
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
36 Hydroxyitraconazole Phase 3
37 Steroid Synthesis Inhibitors Phase 3
38
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
39
Ifosfamide Approved Phase 2 3778-73-2 3690
40
Mechlorethamine Approved Phase 2 51-75-2 4033
41
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
42
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
43
Lenograstim Approved Phase 2 135968-09-1
44
Oprelvekin Approved, Investigational Phase 2 145941-26-0
45
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
46 Albumin-Bound Paclitaxel Phase 2
47 Antimitotic Agents Phase 2
48 Antineoplastic Agents, Phytogenic Phase 2
49 Isophosphamide mustard Phase 2
50 Angiogenesis Inhibitors Phase 2,Phase 1

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3
2 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
3 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3
4 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
5 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3
6 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2
7 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2
8 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2
9 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
10 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
11 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
12 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
13 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1
14 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
15 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021
16 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465
17 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Active, not recruiting NCT01080521

Search NIH Clinical Center for Polyembryoma

Genetic Tests for Polyembryoma

Anatomical Context for Polyembryoma

MalaCards organs/tissues related to Polyembryoma:

39
Ovary, Testes, Testis

Publications for Polyembryoma

Articles related to Polyembryoma:

(show all 15)
id Title Authors Year
1
The Polyembryoma: One of the Most Intriguing Human Neoplasms, With Comments on the Investigator Who Brought it to Light, Albert Peyron. ( 26840034 )
2016
2
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. ( 19437819 )
2008
3
Testicular mixed germ cell tumor with polyembryoma component in brothers. ( 15803215 )
2005
4
Mediastinal polyembryoma associated with Klinefelter syndrome. ( 12679648 )
2003
5
Ovarian mixed germ cell tumor with predominance of polyembryoma: a case report with literature review. ( 11781529 )
2002
6
Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. ( 9605457 )
1998
7
Ovarian mixed germ cell tumor composed of polyembryoma and immature teratoma. ( 9648599 )
1998
8
[Histopathological and immunohistochemical study of ovarian polyembryoma]. ( 7538460 )
1995
9
Conservative management of an ovarian polyembryoma. ( 8159384 )
1994
10
Mixed germ cell tumor of the ovary with a prominent polyembryoma component. ( 1848837 )
1991
11
Retroperitoneal giant tumor formed by migrating polyembryoma with numerous embryoid bodies from an ovarian mixed germ cell tumor. ( 1849112 )
1991
12
Polyembryoma of testis. ( 2986435 )
1985
13
Polyembryoma of ovary producing alpha-fetoprotein and HCG: immunoperoxidase and electron microscopic study. ( 6176314 )
1982
14
Sexual precocity and thoracic polyembryoma: Klinefelter syndrome? ( 758406 )
1979
15
Sexual precocity in a male due to thoracic polyembryoma. ( 73579 )
1978

Variations for Polyembryoma

Expression for Polyembryoma

Search GEO for disease gene expression data for Polyembryoma.

Pathways for Polyembryoma

Pathways related to Polyembryoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.08 AFP SERPINA1
2 10.54 AFP CGA

GO Terms for Polyembryoma

Cellular components related to Polyembryoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.13 AFP CGA SERPINA1
2 endoplasmic reticulum lumen GO:0005788 8.62 AFP SERPINA1

Biological processes related to Polyembryoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 8.96 AFP SERPINA1
2 cellular protein metabolic process GO:0044267 8.62 AFP SERPINA1

Sources for Polyembryoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....