MCID: PLY036
MIFTS: 29

Polyembryoma malady

Rare diseases, Cancer diseases categories

Summaries for Polyembryoma

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NIH Rare Diseases:43 Polyembryoma is a type of tumor that develops from the cells of the gonads (testes in men or ovaries in women).  such tumors are called germ cell tumors.  polyembryomas have a distinctive look because they are composed of many parts that are shaped like embryos, one of the earliest stages of a developing human during pregnancy.  symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain in some individuals; puberty at an unusually young age (known as precocious puberty); or irregularities in a female's menstruation.  treatment begins with surgery and may be followed by chemotherapy and/or radiation therapy.  the cause of polyembryoma is not yet known. last updated: 3/20/2012

MalaCards based summary: Polyembryoma is related to teratoma and choriocarcinoma. An important gene associated with Polyembryoma is AFP (alpha-fetoprotein), and among its related pathways is Glucocorticoid receptor regulatory network. The compounds oestriol and clomiphene citrate have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and testis.

Wikipedia:65 Polyembryoma is a rare, very aggressive form of germ cell tumor usually found in the ovaries.... more...

Aliases & Classifications for Polyembryoma

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Sources:
43NIH Rare Diseases, 49Orphanet, 62UMLS, 63UMLS via Orphanet
See all sources

Polyembryoma, Aliases & Descriptions:

Name: Polyembryoma 43 49 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 49 
Rare tumors


External Ids:

Orphanet49 180229
UMLS via Orphanet63 C0334518

Related Diseases for Polyembryoma

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Diseases related to Polyembryoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 21)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma30.3CGA, AFP
2choriocarcinoma30.0AFP, CGA
3mixed germ cell tumor10.5
4testis polyembryoma10.4
5polyembryoma of the ovary10.3
6mediastinitis10.0
7leydig cell tumor10.0CGA
8endodermal sinus tumor10.0AFP
9oligohydramnios10.0AFP
10testicular teratoma10.0CGA, AFP
11edwards syndrome10.0CGA, AFP
12anencephaly10.0AFP, CGA
13germinoma10.0AFP, CGA
14germ cell cancer10.0AFP, CGA
15dysgerminoma10.0AFP, CGA
16neural tube defects10.0AFP, CGA
17testicular cancer10.0AFP, CGA
18seminoma10.0AFP, CGA
19embryonal cancer10.0CGA, AFP
20preeclampsia/eclampsia 110.0CGA, AFP
21down syndrome10.0CGA, AFP

Graphical network of the top 20 diseases related to Polyembryoma:



Diseases related to polyembryoma

Symptoms for Polyembryoma

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Drugs & Therapeutics for Polyembryoma

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Drug clinical trials:

Search ClinicalTrials for Polyembryoma

Search NIH Clinical Center for Polyembryoma

Genetic Tests for Polyembryoma

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Anatomical Context for Polyembryoma

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MalaCards organs/tissues related to Polyembryoma:

33
Ovary, Testes, Testis

Animal Models for Polyembryoma or affiliated genes

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Publications for Polyembryoma

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Articles related to Polyembryoma:

(show all 14)
idTitleAuthorsYear
1
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. (19437819)
2008
2
Testicular mixed germ cell tumor with polyembryoma component in brothers. (15803215)
2005
3
Mediastinal polyembryoma associated with Klinefelter syndrome. (12679648)
2003
4
Ovarian mixed germ cell tumor with predominance of polyembryoma: a case report with literature review. (11781529)
2002
5
Ovarian mixed germ cell tumor composed of polyembryoma and immature teratoma. (9648599)
1998
6
Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. (9605457)
1998
7
Histopathological and immunohistochemical study of ovarian polyembryoma]. (7538460)
1995
8
Conservative management of an ovarian polyembryoma. (8159384)
1994
9
Mixed germ cell tumor of the ovary with a prominent polyembryoma component. (1848837)
1991
10
Retroperitoneal giant tumor formed by migrating polyembryoma with numerous embryoid bodies from an ovarian mixed germ cell tumor. (1849112)
1991
11
Polyembryoma of testis. (2986435)
1985
12
Polyembryoma of ovary producing alpha-fetoprotein and HCG: immunoperoxidase and electron microscopic study. (6176314)
1982
13
Sexual precocity and thoracic polyembryoma: Klinefelter syndrome? (758406)
1979
14
Sexual precocity in a male due to thoracic polyembryoma. (73579)
1978

Variations for Polyembryoma

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Expression for genes affiliated with Polyembryoma

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Search GEO for disease gene expression data for Polyembryoma.

Pathways for genes affiliated with Polyembryoma

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Pathways related to Polyembryoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CGA, AFP

Compounds for genes affiliated with Polyembryoma

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Compounds related to Polyembryoma according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1oestriol459.5CGA, AFP
2clomiphene citrate459.5CGA, AFP
3ifosfamide45 1310.5CGA, AFP
4diethylstilbestrol45 30 1311.5CGA, AFP
5vinblastine45 51 1311.5AFP, CGA
6bleomycin45 1310.5CGA, AFP
7carboplatin45 51 1311.5CGA, AFP
8mifepristone45 30 61 1312.5CGA, AFP
9sialic acid459.5AFP, CGA
10thyroxine45 2610.5CGA, AFP
11carbon459.5CGA, AFP
12cyclophosphamide45 51 1311.5AFP, CGA
13folate459.5CGA, AFP
14dmso459.5AFP, CGA
15methotrexate51 45 1311.5CGA, AFP
16epinephrine45 26 1311.5CGA, AFP
17etoposide45 51 61 1312.5CGA, AFP
18vitamin d459.5AFP, CGA
19doxorubicin45 51 1311.4CGA, AFP
20actinomycin d459.4CGA, AFP
21estradiol45 26 1311.4AFP, CGA
22paraffin459.4CGA, AFP
23lactate459.4AFP, CGA
24cisplatin45 51 61 1312.4CGA, AFP
25creatinine459.4CGA, AFP
26aspartate459.4CGA, AFP
27heparin45 30 26 1312.3AFP, CGA
28progesterone45 30 61 26 1313.3CGA, AFP
29h2o2459.3CGA, AFP
30testosterone45 61 26 1312.2CGA, AFP
31steroid459.2AFP, CGA
32vegf459.1CGA, AFP
33estrogen459.1CGA, AFP
34glutamate459.0CGA, AFP
35alanine458.8CGA, AFP

GO Terms for genes affiliated with Polyembryoma

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Products for genes affiliated with Polyembryoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Polyembryoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet