MCID: PLY036
MIFTS: 22

Polyembryoma malady

Cancer diseases category

Summaries for Polyembryoma

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Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Polyembryoma is a type of tumor that develops from the cells of the gonads (testes in men or ovaries in women).  such tumors are called germ cell tumors.  polyembryomas have a distinctive look because they are composed of many parts that are shaped like embryos, one of the earliest stages of a developing human during pregnancy.  symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain in some individuals; puberty at an unusually young age (known as precocious puberty); or irregularities in a female's menstruation.  treatment begins with surgery and may be followed by chemotherapy and/or radiation therapy.  the cause of polyembryoma is not yet known. last updated: 3/20/2012

MalaCards: Polyembryoma is related to choriocarcinoma and testis polyembryoma. An important gene associated with Polyembryoma is AFP (alpha-fetoprotein), and among its related pathways is Glucocorticoid receptor regulatory network. The compounds oestriol and clomiphene citrate have been mentioned in the context of this disorder. Affiliated tissues include ovary and testes.

Wikipedia:63 Polyembryoma is a rare, very aggressive form of germ cell tumor usually found in the ovaries.... more...

Aliases & Classifications for Polyembryoma

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Sources:
42NIH Rare Diseases, 48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

polyembryoma 42 48 60


External Ids:

SNOMED-CT via Orphanet57 28325008
UMLS via Orphanet61 C0334518

Related Diseases for Polyembryoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Polyembryoma:



Diseases related to polyembryoma

Clinical Features for Polyembryoma

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Drugs & Therapeutics for Polyembryoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Polyembryoma

Drug clinical trials:

Search ClinicalTrials for Polyembryoma

Search NIH Clinical Center for Polyembryoma

Search CenterWatch for Polyembryoma

Genetic Tests for Polyembryoma

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Anatomical Context for Polyembryoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Polyembryoma:

32
Ovary, Testes

Animal Models for Polyembryoma or affiliated genes

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Publications for Polyembryoma

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Genetic Variations for Polyembryoma

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Expression for genes affiliated with Polyembryoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyembryoma

Search GEO for disease gene expression data for Polyembryoma.

Pathways for genes affiliated with Polyembryoma

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Sources:
37NCBI BioSystems Database
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Pathways related to Polyembryoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1AFP, CGA

Compounds for genes affiliated with Polyembryoma

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Polyembryoma according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1oestriol449.5AFP, CGA
2clomiphene citrate449.5AFP, CGA
3ifosfamide44 1110.5AFP, CGA
4diethylstilbestrol44 28 1111.5CGA, AFP
5vinblastine44 49 1111.5AFP, CGA
6carboplatin44 49 1111.5AFP, CGA
7bleomycin44 1110.5AFP, CGA
8mifepristone44 59 28 1112.5CGA, AFP
9sialic acid449.5AFP, CGA
10thyroxine44 2410.5AFP, CGA
11cyclophosphamide44 49 1111.5AFP, CGA
12carbon449.5CGA, AFP
13folate449.5AFP, CGA
14dmso449.4AFP, CGA
15methotrexate44 49 1111.4AFP, CGA
16epinephrine44 11 2411.4CGA, AFP
17etoposide44 49 59 1112.4AFP, CGA
18vitamin d449.4AFP, CGA
19doxorubicin44 49 1111.4AFP, CGA
20actinomycin d449.4CGA, AFP
21estradiol44 11 2411.4AFP, CGA
22paraffin449.3AFP, CGA
23lactate449.3CGA, AFP
24cisplatin44 49 59 1112.3AFP, CGA
25creatinine449.2AFP, CGA
26aspartate449.2AFP, CGA
27heparin44 28 11 2412.1CGA, AFP
28testosterone44 59 11 2412.1AFP, CGA
29progesterone44 59 28 11 2413.0AFP, CGA
30h2o2448.8AFP, CGA

GO Terms for genes affiliated with Polyembryoma

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Products for genes affiliated with Polyembryoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polyembryoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet