MCID: PLY036
MIFTS: 25

Polyembryoma malady

Rare diseases, Cancer diseases categories

Summaries for Polyembryoma

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NIH Rare Diseases:41 Polyembryoma is a type of tumor that develops from the cells of the gonads (testes in men or ovaries in women).  such tumors are called germ cell tumors.  polyembryomas have a distinctive look because they are composed of many parts that are shaped like embryos, one of the earliest stages of a developing human during pregnancy.  symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain in some individuals; puberty at an unusually young age (known as precocious puberty); or irregularities in a female's menstruation.  treatment begins with surgery and may be followed by chemotherapy and/or radiation therapy.  the cause of polyembryoma is not yet known. last updated: 3/20/2012

MalaCards based summary: Polyembryoma is related to teratoma and choriocarcinoma. An important gene associated with Polyembryoma is AFP (alpha-fetoprotein), and among its related pathways is Glucocorticoid receptor regulatory network. The compounds oestriol and clomiphene citrate have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and testis.

Wikipedia:63 Polyembryoma is a rare, very aggressive form of germ cell tumor usually found in the ovaries.... more...

Aliases & Classifications for Polyembryoma

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Sources:
41NIH Rare Diseases, 47Orphanet, 60UMLS, 61UMLS via Orphanet
See all sources

Polyembryoma, Aliases & Descriptions:

Name: Polyembryoma 41 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 47 
Rare tumors


External Ids:

Orphanet47 180229
UMLS via Orphanet61 C0334518

Related Diseases for Polyembryoma

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Graphical network of the top 20 diseases related to Polyembryoma:



Diseases related to polyembryoma

Symptoms for Polyembryoma

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Drugs & Therapeutics for Polyembryoma

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Drug clinical trials:

Search ClinicalTrials for Polyembryoma

Search NIH Clinical Center for Polyembryoma

Genetic Tests for Polyembryoma

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Anatomical Context for Polyembryoma

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MalaCards organs/tissues related to Polyembryoma:

31
Ovary, Testes, Testis

Animal Models for Polyembryoma or affiliated genes

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Publications for Polyembryoma

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Articles related to Polyembryoma:

(show all 14)
idTitleAuthorsYear
1
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. (19437819)
2008
2
Testicular mixed germ cell tumor with polyembryoma component in brothers. (15803215)
2005
3
Mediastinal polyembryoma associated with Klinefelter syndrome. (12679648)
2003
4
Ovarian mixed germ cell tumor with predominance of polyembryoma: a case report with literature review. (11781529)
2002
5
Ovarian mixed germ cell tumor composed of polyembryoma and immature teratoma. (9648599)
1998
6
Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. (9605457)
1998
7
Histopathological and immunohistochemical study of ovarian polyembryoma]. (7538460)
1995
8
Conservative management of an ovarian polyembryoma. (8159384)
1994
9
Mixed germ cell tumor of the ovary with a prominent polyembryoma component. (1848837)
1991
10
Retroperitoneal giant tumor formed by migrating polyembryoma with numerous embryoid bodies from an ovarian mixed germ cell tumor. (1849112)
1991
11
Polyembryoma of testis. (2986435)
1985
12
Polyembryoma of ovary producing alpha-fetoprotein and HCG: immunoperoxidase and electron microscopic study. (6176314)
1982
13
Sexual precocity and thoracic polyembryoma: Klinefelter syndrome? (758406)
1979
14
Sexual precocity in a male due to thoracic polyembryoma. (73579)
1978

Variations for Polyembryoma

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Expression for genes affiliated with Polyembryoma

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Search GEO for disease gene expression data for Polyembryoma.

Pathways for genes affiliated with Polyembryoma

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Pathways related to Polyembryoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CGA, AFP

Compounds for genes affiliated with Polyembryoma

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Compounds related to Polyembryoma according to GeneCards Suite gene sharing:

(show all 35)
idCompoundScoreTop Affiliating Genes
1oestriol439.5CGA, AFP
2clomiphene citrate439.5CGA, AFP
3ifosfamide43 1210.5CGA, AFP
4diethylstilbestrol43 28 1211.5CGA, AFP
5vinblastine43 49 1211.5AFP, CGA
6bleomycin43 1210.5CGA, AFP
7carboplatin43 49 1211.5CGA, AFP
8mifepristone43 28 59 1212.5CGA, AFP
9sialic acid439.5AFP, CGA
10thyroxine43 2410.5CGA, AFP
11carbon439.5CGA, AFP
12cyclophosphamide43 49 1211.5AFP, CGA
13folate439.5CGA, AFP
14dmso439.5AFP, CGA
15methotrexate49 43 1211.5CGA, AFP
16epinephrine43 24 1211.5CGA, AFP
17etoposide43 49 59 1212.5CGA, AFP
18vitamin d439.5AFP, CGA
19doxorubicin43 49 1211.4CGA, AFP
20actinomycin d439.4CGA, AFP
21estradiol43 24 1211.4AFP, CGA
22paraffin439.4CGA, AFP
23lactate439.4AFP, CGA
24cisplatin43 49 59 1212.4CGA, AFP
25creatinine439.4CGA, AFP
26aspartate439.4CGA, AFP
27heparin43 28 24 1212.3AFP, CGA
28progesterone43 28 59 24 1213.3CGA, AFP
29h2o2439.3CGA, AFP
30testosterone43 59 24 1212.2CGA, AFP
31steroid439.2AFP, CGA
32vegf439.1CGA, AFP
33estrogen439.1CGA, AFP
34glutamate439.0CGA, AFP
35alanine438.8CGA, AFP

GO Terms for genes affiliated with Polyembryoma

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Products for genes affiliated with Polyembryoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Polyembryoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet