Aliases & Classifications for Polyembryoma

MalaCards integrated aliases for Polyembryoma:

Name: Polyembryoma 50 56 69
Gonadal Polyembryoma 50 69

Classifications:



External Ids:

Orphanet 56 ORPHA180229
UMLS via Orphanet 70 C0334518

Summaries for Polyembryoma

NIH Rare Diseases : 50 polyembryoma is a type of tumor that develops from the cells of the gonads (testes in men or ovaries in women).  such tumors are called germ cell tumors.  polyembryomas have a distinctive look because they are composed of many parts that are shaped like embryos, one of the earliest stages of a developing human during pregnancy.  symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain in some individuals; puberty at an unusually young age (known as precocious puberty); or irregularities in a female's menstruation.  treatment begins with surgery and may be followed by chemotherapy and/or radiation therapy.  the cause of polyembryoma is not yet known. last updated: 3/20/2012

MalaCards based summary : Polyembryoma, also known as gonadal polyembryoma, is related to testis polyembryoma and polyembryoma of the ovary. An important gene associated with Polyembryoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Glucocorticoid receptor regulatory network. The drugs Palivizumab and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and bone marrow.

Wikipedia : 72 Polyembryoma is a rare, very aggressive form of germ cell tumor usually found in the ovaries.... more...

Related Diseases for Polyembryoma

Graphical network of the top 20 diseases related to Polyembryoma:



Diseases related to Polyembryoma

Symptoms & Phenotypes for Polyembryoma

Drugs & Therapeutics for Polyembryoma

Drugs for Polyembryoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palivizumab Approved, Investigational Phase 3 188039-54-5
2
Ribavirin Approved Phase 3 36791-04-5 37542
3
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
4
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6
Captopril Approved Phase 3 62571-86-2 44093
7
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
8
Fluconazole Approved Phase 3 86386-73-4 3365
9
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
10 Antibodies Phase 3,Phase 1
11 Antibodies, Monoclonal Phase 3,Phase 1
12 Anti-Infective Agents Phase 3,Phase 2
13 Antimetabolites Phase 3
14 Antiviral Agents Phase 3,Phase 2
15 Immunoglobulins Phase 3,Phase 1
16 Anti-Bacterial Agents Phase 3
17 Antifungal Agents Phase 3
18 Antiparasitic Agents Phase 3
19 Antiprotozoal Agents Phase 3
20 Echinocandins Phase 3
21 Liposomal amphotericin B Phase 3
22 Alkylating Agents Phase 3,Phase 2
23 Angiotensin-Converting Enzyme Inhibitors Phase 3
24 Antihypertensive Agents Phase 3
25 Antirheumatic Agents Phase 3
26 HIV Protease Inhibitors Phase 3
27 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
28
protease inhibitors Phase 3
29 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
30 Cytochrome P-450 CYP3A Inhibitors Phase 3
31 Cytochrome P-450 Enzyme Inhibitors Phase 3
32 Hormone Antagonists Phase 3,Phase 1,Phase 2
33 Hormones Phase 3,Phase 1,Phase 2
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
35 Hydroxyitraconazole Phase 3
36 Steroid Synthesis Inhibitors Phase 3
37
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
38
Ifosfamide Approved Phase 2 3778-73-2 3690
39
Mechlorethamine Approved Phase 2 51-75-2 4033
40
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
41
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
42
Lenograstim Approved Phase 2 135968-09-1
43
Oprelvekin Approved, Investigational Phase 2 145941-26-0
44
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
45 Albumin-Bound Paclitaxel Phase 2
46 Antimitotic Agents Phase 2
47 Antineoplastic Agents, Phytogenic Phase 2
48 Isophosphamide mustard Phase 2
49 Angiogenesis Inhibitors Phase 2,Phase 1
50 Angiogenesis Modulating Agents Phase 2,Phase 1

Interventional clinical trials:

(show all 17)

id Name Status NCT ID Phase Drugs
1 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
2 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
3 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
4 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
5 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
6 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
7 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
8 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
9 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
10 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
11 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
12 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
13 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
14 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
15 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021
16 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465
17 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Active, not recruiting NCT01080521

Search NIH Clinical Center for Polyembryoma

Genetic Tests for Polyembryoma

Anatomical Context for Polyembryoma

MalaCards organs/tissues related to Polyembryoma:

39
Ovary, Testes, Bone Marrow, Bone, Brain, Colon, Small Intestine

Publications for Polyembryoma

Articles related to Polyembryoma:

(show all 16)
id Title Authors Year
1
Polyembryoma of the testis: a report of two cases dominant within mixed germ cell tumors and review of gonadal polyembryomas. ( 28429716 )
2017
2
The Polyembryoma: One of the Most Intriguing Human Neoplasms, With Comments on the Investigator Who Brought it to Light, Albert Peyron. ( 26840034 )
2016
3
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. ( 19437819 )
2008
4
Testicular mixed germ cell tumor with polyembryoma component in brothers. ( 15803215 )
2005
5
Mediastinal polyembryoma associated with Klinefelter syndrome. ( 12679648 )
2003
6
Ovarian mixed germ cell tumor with predominance of polyembryoma: a case report with literature review. ( 11781529 )
2002
7
Ovarian mixed germ cell tumor composed of polyembryoma and immature teratoma. ( 9648599 )
1998
8
Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. ( 9605457 )
1998
9
[Histopathological and immunohistochemical study of ovarian polyembryoma]. ( 7538460 )
1995
10
Conservative management of an ovarian polyembryoma. ( 8159384 )
1994
11
Retroperitoneal giant tumor formed by migrating polyembryoma with numerous embryoid bodies from an ovarian mixed germ cell tumor. ( 1849112 )
1991
12
Mixed germ cell tumor of the ovary with a prominent polyembryoma component. ( 1848837 )
1991
13
Polyembryoma of testis. ( 2986435 )
1985
14
Polyembryoma of ovary producing alpha-fetoprotein and HCG: immunoperoxidase and electron microscopic study. ( 6176314 )
1982
15
Sexual precocity and thoracic polyembryoma: Klinefelter syndrome? ( 758406 )
1979
16
Sexual precocity in a male due to thoracic polyembryoma. ( 73579 )
1978

Variations for Polyembryoma

Expression for Polyembryoma

Search GEO for disease gene expression data for Polyembryoma.

Pathways for Polyembryoma

Pathways related to Polyembryoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.08 AFP SERPINA1
2 10.54 AFP CGA

GO Terms for Polyembryoma

Cellular components related to Polyembryoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.13 AFP CGA SERPINA1
2 endoplasmic reticulum lumen GO:0005788 8.62 AFP SERPINA1

Biological processes related to Polyembryoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 8.96 AFP SERPINA1
2 cellular protein metabolic process GO:0044267 8.62 AFP SERPINA1

Sources for Polyembryoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
38 LifeMap
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44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
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55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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