MCID: PLY036
MIFTS: 29

Polyembryoma malady

Rare diseases, Cancer diseases categories

Summaries for Polyembryoma

About this section
Sources:
44NIH Rare Diseases, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
NIH Rare Diseases:44 Polyembryoma is a type of tumor that develops from the cells of the gonads (testes in men or ovaries in women).  such tumors are called germ cell tumors.  polyembryomas have a distinctive look because they are composed of many parts that are shaped like embryos, one of the earliest stages of a developing human during pregnancy.  symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain in some individuals; puberty at an unusually young age (known as precocious puberty); or irregularities in a female's menstruation.  treatment begins with surgery and may be followed by chemotherapy and/or radiation therapy.  the cause of polyembryoma is not yet known. last updated: 3/20/2012

MalaCards: Polyembryoma is related to teratoma and choriocarcinoma. An important gene associated with Polyembryoma is AFP (alpha-fetoprotein), and among its related pathways is Glucocorticoid receptor regulatory network. The compounds oestriol and clomiphene citrate have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and testis.

Wikipedia:66 Polyembryoma is a rare, very aggressive form of germ cell tumor usually found in the ovaries.... more...

Aliases & Classifications for Polyembryoma

About this section
Sources:
44NIH Rare Diseases, 50Orphanet, 63UMLS, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 50 
Rare tumors


Aliases & Descriptions:

polyembryoma 44 50 63


External Ids:

SNOMED-CT via Orphanet60 28325008
UMLS via Orphanet64 C0334518

Related Diseases for Polyembryoma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Polyembryoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 22)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma30.2CGA, AFP
2choriocarcinoma29.9AFP, CGA
3germ cell tumors10.4
4mixed germ cell tumor10.4
5testis polyembryoma10.3
6polyembryoma of the ovary10.2
7leydig cell tumor10.1CGA
8endodermal sinus tumor10.1AFP
9oligohydramnios10.0AFP
10mediastinitis10.0
11male germ cell tumor, somatic10.0CGA, AFP
12edwards syndrome10.0CGA, AFP
13anencephaly10.0AFP, CGA
14germinoma10.0AFP, CGA
15germ cell cancer10.0AFP, CGA
16dysgerminoma10.0AFP, CGA
17neural tube defects10.0AFP, CGA
18testicular cancer10.0AFP, CGA
19seminoma10.0AFP, CGA
20embryonal cancer10.0CGA, AFP
21pre-eclampsia10.0CGA, AFP
22down syndrome10.0CGA, AFP

Graphical network of the top 20 diseases related to Polyembryoma:



Diseases related to polyembryoma

Symptoms for Polyembryoma

About this section

Drugs & Therapeutics for Polyembryoma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Polyembryoma

Drug clinical trials:

Search ClinicalTrials for Polyembryoma

Search NIH Clinical Center for Polyembryoma

Search CenterWatch for Polyembryoma

Genetic Tests for Polyembryoma

About this section

Anatomical Context for Polyembryoma

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Polyembryoma:

34
Ovary, Testes, Testis

Animal Models for Polyembryoma or affiliated genes

About this section

Publications for Polyembryoma

About this section
Sources:
53PubMed
See all sources

Articles related to Polyembryoma:

(show all 13)
idTitleAuthorsYear
1
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. (19437819)
2008
2
Testicular mixed germ cell tumor with polyembryoma component in brothers. (15803215)
2005
3
Mediastinal polyembryoma associated with Klinefelter syndrome. (12679648)
2003
4
Ovarian mixed germ cell tumor with predominance of polyembryoma: a case report with literature review. (11781529)
2002
5
Ovarian mixed germ cell tumor composed of polyembryoma and immature teratoma. (9648599)
1998
6
Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. (9605457)
1998
7
Histopathological and immunohistochemical study of ovarian polyembryoma]. (7538460)
1995
8
Conservative management of an ovarian polyembryoma. (8159384)
1994
9
Mixed germ cell tumor of the ovary with a prominent polyembryoma component. (1848837)
1991
10
Polyembryoma of testis. (2986435)
1985
11
Polyembryoma of ovary producing alpha-fetoprotein and HCG: immunoperoxidase and electron microscopic study. (6176314)
1982
12
Sexual precocity and thoracic polyembryoma: Klinefelter syndrome? (758406)
1979
13
Sexual precocity in a male due to thoracic polyembryoma. (73579)
1978

Variations for Polyembryoma

About this section

Expression for genes affiliated with Polyembryoma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Polyembryoma

Search GEO for disease gene expression data for Polyembryoma.

Pathways for genes affiliated with Polyembryoma

About this section
Sources:
51PathCards, 39NCBI BioSystems Database
See all sources

Pathways related to Polyembryoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CGA, AFP

Compounds for genes affiliated with Polyembryoma

About this section
Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 25HMDB
See all sources

Compounds related to Polyembryoma according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1oestriol469.5CGA, AFP
2clomiphene citrate469.5CGA, AFP
3ifosfamide46 1210.5CGA, AFP
4diethylstilbestrol46 30 1211.5CGA, AFP
5vinblastine46 52 1211.5AFP, CGA
6bleomycin46 1210.5CGA, AFP
7carboplatin46 52 1211.5CGA, AFP
8mifepristone46 30 62 1212.5CGA, AFP
9sialic acid469.5AFP, CGA
10thyroxine46 2510.5CGA, AFP
11carbon469.5CGA, AFP
12cyclophosphamide46 52 1211.5AFP, CGA
13folate469.5CGA, AFP
14dmso469.5AFP, CGA
15methotrexate52 46 1211.5CGA, AFP
16epinephrine46 25 1211.5CGA, AFP
17etoposide46 52 62 1212.5CGA, AFP
18vitamin d469.5AFP, CGA
19doxorubicin46 52 1211.4CGA, AFP
20actinomycin d469.4CGA, AFP
21estradiol46 25 1211.4AFP, CGA
22paraffin469.4CGA, AFP
23lactate469.4AFP, CGA
24cisplatin46 52 62 1212.4CGA, AFP
25creatinine469.4CGA, AFP
26aspartate469.4CGA, AFP
27heparin46 30 25 1212.3AFP, CGA
28progesterone46 30 62 25 1213.3CGA, AFP
29h2o2469.3CGA, AFP
30testosterone46 62 25 1212.2CGA, AFP
31steroid469.2AFP, CGA
32vegf469.1CGA, AFP
33estrogen469.1CGA, AFP
34glutamate469.0CGA, AFP
35alanine468.8CGA, AFP

GO Terms for genes affiliated with Polyembryoma

About this section

Products for genes affiliated with Polyembryoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polyembryoma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet