MCID: PLY036
MIFTS: 28

Polyembryoma malady

Rare diseases, Cancer diseases categories
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Summaries for Polyembryoma

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NIH Rare Diseases:42 Polyembryoma is a type of tumor that develops from the cells of the gonads (testes in men or ovaries in women).  such tumors are called germ cell tumors.  polyembryomas have a distinctive look because they are composed of many parts that are shaped like embryos, one of the earliest stages of a developing human during pregnancy.  symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain in some individuals; puberty at an unusually young age (known as precocious puberty); or irregularities in a female's menstruation.  treatment begins with surgery and may be followed by chemotherapy and/or radiation therapy.  the cause of polyembryoma is not yet known. last updated: 3/20/2012

MalaCards based summary: Polyembryoma is related to teratoma and choriocarcinoma. An important gene associated with Polyembryoma is AFP (alpha-fetoprotein), and among its related pathways is Glucocorticoid receptor regulatory network. The compounds oestriol and clomiphene citrate have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and testis.

Wikipedia:65 Polyembryoma is a rare, very aggressive form of germ cell tumor usually found in the ovaries.... more...

Aliases & Classifications for Polyembryoma

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Sources:
42NIH Rare Diseases, 48Orphanet, 62UMLS, 63UMLS via Orphanet
See all sources

Polyembryoma, Aliases & Descriptions:

Name: Polyembryoma 42 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 48 
Rare tumors


External Ids:

UMLS via Orphanet63 C0334518

Related Diseases for Polyembryoma

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Graphical network of the top 20 diseases related to Polyembryoma:



Diseases related to polyembryoma

Symptoms for Polyembryoma

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Drugs & Therapeutics for Polyembryoma

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Drug clinical trials:

Search ClinicalTrials for Polyembryoma

Search NIH Clinical Center for Polyembryoma

Genetic Tests for Polyembryoma

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Anatomical Context for Polyembryoma

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MalaCards organs/tissues related to Polyembryoma:

32
Ovary, Testes, Testis

Animal Models for Polyembryoma or affiliated genes

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Publications for Polyembryoma

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Articles related to Polyembryoma:

(show all 14)
idTitleAuthorsYear
1
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. (19437819)
2008
2
Testicular mixed germ cell tumor with polyembryoma component in brothers. (15803215)
2005
3
Mediastinal polyembryoma associated with Klinefelter syndrome. (12679648)
2003
4
Ovarian mixed germ cell tumor with predominance of polyembryoma: a case report with literature review. (11781529)
2002
5
Ovarian mixed germ cell tumor composed of polyembryoma and immature teratoma. (9648599)
1998
6
Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. (9605457)
1998
7
Histopathological and immunohistochemical study of ovarian polyembryoma]. (7538460)
1995
8
Conservative management of an ovarian polyembryoma. (8159384)
1994
9
Mixed germ cell tumor of the ovary with a prominent polyembryoma component. (1848837)
1991
10
Retroperitoneal giant tumor formed by migrating polyembryoma with numerous embryoid bodies from an ovarian mixed germ cell tumor. (1849112)
1991
11
Polyembryoma of testis. (2986435)
1985
12
Polyembryoma of ovary producing alpha-fetoprotein and HCG: immunoperoxidase and electron microscopic study. (6176314)
1982
13
Sexual precocity and thoracic polyembryoma: Klinefelter syndrome? (758406)
1979
14
Sexual precocity in a male due to thoracic polyembryoma. (73579)
1978

Variations for Polyembryoma

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Expression for genes affiliated with Polyembryoma

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Expression patterns in normal tissues for genes affiliated with Polyembryoma

Search GEO for disease gene expression data for Polyembryoma.

Pathways for genes affiliated with Polyembryoma

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Pathways related to Polyembryoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CGA, AFP

Compounds for genes affiliated with Polyembryoma

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Compounds related to Polyembryoma according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1oestriol449.5CGA, AFP
2clomiphene citrate449.5CGA, AFP
3ifosfamide44 1110.5CGA, AFP
4diethylstilbestrol44 28 1111.5CGA, AFP
5vinblastine44 50 1111.5AFP, CGA
6bleomycin44 1110.5CGA, AFP
7carboplatin44 50 1111.5CGA, AFP
8mifepristone44 28 61 1112.5CGA, AFP
9sialic acid449.5AFP, CGA
10thyroxine44 2410.5CGA, AFP
11carbon449.5CGA, AFP
12cyclophosphamide44 50 1111.5AFP, CGA
13folate449.5CGA, AFP
14dmso449.5AFP, CGA
15methotrexate50 44 1111.5CGA, AFP
16epinephrine44 24 1111.5CGA, AFP
17etoposide44 50 61 1112.5CGA, AFP
18vitamin d449.5AFP, CGA
19doxorubicin44 50 1111.4CGA, AFP
20actinomycin d449.4CGA, AFP
21estradiol44 24 1111.4AFP, CGA
22paraffin449.4CGA, AFP
23lactate449.4AFP, CGA
24cisplatin44 50 61 1112.4CGA, AFP
25creatinine449.4CGA, AFP
26aspartate449.4CGA, AFP
27heparin44 28 24 1112.3AFP, CGA
28progesterone44 28 61 24 1113.3CGA, AFP
29h2o2449.3CGA, AFP
30testosterone44 61 24 1112.2CGA, AFP
31steroid449.2AFP, CGA
32vegf449.1CGA, AFP
33estrogen449.1CGA, AFP
34glutamate449.0CGA, AFP
35alanine448.8CGA, AFP

GO Terms for genes affiliated with Polyembryoma

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Products for genes affiliated with Polyembryoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Polyembryoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet