MCID: PLY012
MIFTS: 54

Polyhydramnios malady

Fetal diseases category
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Summaries for Polyhydramnios

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Polyhydramnios (polyhydramnion, hydramnios, polyhydramnios) is a medical condition describing an excess... more...

MalaCards: Polyhydramnios is related to oligohydramnios and diabetes insipidus. An important gene associated with Polyhydramnios is STRADA (STE20-related kinase adaptor alpha), and among its related pathways are Insulin receptor signalling cascade and Diuretics Pathway, Pharmacodynamics. The compounds pcmbs and hgcl2 have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and lung, and related mouse phenotypes are hearing/vestibular/ear and nervous system.

Disease Ontology:8 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

Aliases & Classifications for Polyhydramnios

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH, 25ICD10
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Related Diseases for Polyhydramnios

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17GeneCards, 18GeneDecks
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Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1oligohydramnios30.9AFP, AQP8, OXT
2diabetes insipidus29.9OXT
3nephrogenic diabetes insipidus29.8AQP3, SLC12A1
4bartter disease29.8BSND, KCNJ1, CLCNKB, SLC12A1
5chorioangioma10.3
6twin twin transfusion syndrome10.2
7mesoblastic nephroma10.2
8twin-to-twin transfusion syndrome10.1
9cervicitis10.1
10congenital mesoblastic nephroma10.1
11myotonic dystrophy10.1
12teratoma10.1
13testicular germ cell tumor10.1STK11, FGFR3
14hydronephrosis10.1
15cerebritis10.1
16costello syndrome10.1
17congenital diaphragmatic hernia10.1
18ovarian cyst10.1
19congenital myotonic dystrophy10.1
20hydrops fetalis10.1
21polyhydramnios, megalencephaly, and symptomatic epilepsy10.1
22hepatorenal syndrome10.1EDN1
23myoma10.1FH, OXT
24hyperaldosteronism10.1CLCNKB, KCNJ1
25meconium aspiration syndrome10.1EDN1, OXT
26hydrocephalus10.1AFP, AQP1
27peutz-jeghers syndrome10.0STRADA, STK11
28bartter syndrome, type 210.0SLC12A1, KCNJ1
29bartter syndrome type 310.0SLC12A1, CLCNKB, KCNJ1
30nephrocalcinosis10.0SLC12A1, CLCNKB, KCNJ1
31sensorineural hearing loss10.0SLC12A1, KCNJ1, BSND
32pre-eclampsia10.0OXT, AFP, EDN1
33cor pulmonale10.0EDN1, NPPB
34hypercalcemia10.0
35pseudohypoaldosteronism10.0
36achondrogenesis type ib10.0
37esophagitis10.0
38laryngitis10.0
39chondrodysplasia blomstrand type10.0
40diffuse neonatal hemangiomatosis10.0
41duodenal atresia10.0
42multiple pterygium syndrome lethal type10.0
43neu laxova syndrome10.0
44renal hamartomas nephroblastomatosis and fetal gigantism10.0
45thanatophoric dysplasia type 110.0
46tight skin contracture syndrome, lethal10.0
47omphalocele10.0
48muscular hypertrophy - hepatomegaly - polyhydramnios10.0
49cystic fibrosis10.0SLC26A3, AQP1, AQP3, KCNJ1
50gitelman syndrome10.0BSND, KCNJ1, CLCNKB, SLC12A1

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to polyhydramnios

Symptoms for Polyhydramnios

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Drugs & Therapeutics for Polyhydramnios

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Polyhydramnios

Search NIH Clinical Center for Polyhydramnios

Genetic Tests for Polyhydramnios

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Anatomical Context for Polyhydramnios

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33MalaCards
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MalaCards organs/tissues related to Polyhydramnios:

33
Placenta, Brain, Lung, Heart, Liver, Bone, Kidney, Fetal lung

Animal Models for Polyhydramnios or affiliated genes

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37MGI
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Publications for Polyhydramnios

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52PubMed
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Articles related to Polyhydramnios:

(show top 50)    (show all 275)
idTitleAuthorsYear
1
Fetal swallowing as a protective mechanism against oligohydramnios and polyhydramnios in late gestation sheep. (22872543)
2013
2
Polyhydramnios: a warning sign in the prenatal ultrasound diagnosis of foetal malformation? (23403339)
2013
3
Polyhydramnios with bidirectional fetal ductus arteriosus flow in a fetus with congenital diaphragmatic hernia: case report. (21082541)
2011
4
The amnioscope strikes back as a useful device for pinhole amniotomy in the management of polyhydramnios. (23705096)
2011
5
Successful management of a high-risk pregnancy with polyhydramnios, IUGR and recurrent pregnancy loss in a chronic renal failure patient: a case report. (21485740)
2011
6
Expression of aquaporin 8 in human fetal membrane and placenta of idiopathic polyhydramnios]. (19563057)
2009
7
Clinical application of fetal urine production rate in unexplained polyhydramnios. (19830790)
2009
8
Expression of aquaporin 3 and aquaporin 9 in placenta and fetal membrane with idiopathic polyhydramnios.]. (20193419)
2009
9
Polyhydramnios. Risk factors and outcome. (18246237)
2008
10
Acute recurrent polyhydramnios: a combination of amniocenteses and NSAID may be curative rather than palliative. (17228156)
2007
11
Outcome of children born out of pregnancies complicated by unexplained polyhydramnios. (17309542)
2007
12
Steady-state levels of aquaporin 1 mRNA expression are increased in idiopathic polyhydramnios. (16522429)
2006
13
Clinical features of polyhydramnios associated with fetal anomalies. (17096817)
2006
14
Use of continuous fluid drainage for severe polyhydramnios due to twin to twin transfusion syndrome. (11491373)
2001
15
Increased urinary flow without development of polyhydramnios in response to prolonged hypoxia in the ovine fetus. (11303213)
2001
16
High levels of fetal erythroblasts and fetal extracellular DNA in the peripheral blood of a pregnant woman with idiopathic polyhydramnios: case report. (11038466)
2000
17
Study of 290 cases of polyhydramnios and congenital malformations in a series of 225,669 consecutive births. (15178961)
1999
18
Polyhydramnios as a first prenatal symptom of non-ketotic hyperglycinaemia. (9742581)
1998
19
Myotonic dystrophy is a significant cause of idiopathic polyhydramnios. (9790382)
1998
20
Abdomino-amniotic shunting in isolated fetal ascites with polyhydramnios. (9292649)
1997
21
New syndrome: brain malformation, growth retardation, hypokinesia and polyhydramnios in two brothers. (9018412)
1997
22
Polyhydramnios is an independent risk factor for perinatal mortality and intrapartum morbidity in preterm delivery. (9031919)
1996
23
Is polyhydramnios in an ultrasonographically normal fetus an indication for genetic evaluation? (7503195)
1995
24
Polyhydramnios: ultrasonic detection of fetal and maternal conditions. (7933915)
1994
25
Significance of idiopathic midtrimester polyhydramnios. (7945628)
1994
26
Fetal renal artery flow velocity waveforms in normal pregnancies and pregnancies complicated by polyhydramnios and oligohydramnios. (8459967)
1993
27
Maternal smoking and the risk of polyhydramnios. (1739142)
1992
28
Reduction in the middle cerebral artery pulsatility index after decompression of polyhydramnios in twin gestation. (1418139)
1992
29
The natural history of oligohydramnios/polyhydramnios sequence in monochorionic diamniotic twins. (12796928)
1992
30
Indomethacin for the treatment of polyhydramnios: a case of constriction of the ductus arteriosus. (1445137)
1992
31
Pathophysiology of congenital diaphragmatic hernia: I. Renal enlargement suggests feedback modulation by pulmonary derived renotropins--a unifying hypothesis to explain pulmonary hypoplasia, polyhydramnios, and renal enlargement in the fetus/newborn with congenital diaphragmatic hernia. (2191107)
1990
32
Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios. (2405319)
1990
33
Acute polyhydramnios in twin pregnancy. A retrospective study with special reference to therapeutic amniocentesis. (2244460)
1990
34
Maternal lithium therapy and polyhydramnios. (2199873)
1990
35
Antenatal evaluation of upper gastrointestinal dilatation complicated by non-immune hydrops fetalis and polyhydramnios. (2697734)
1989
36
Acute polyhydramnios. (2563707)
1989
37
Prenatal diagnosis of congenital mesoblastic nephroma in association with polyhydramnios. (2845674)
1988
38
Treacher-Collins syndrome: an association with polyhydramnios. (3141842)
1988
39
Placental chorioangioma, an unusual cause of polyhydramnios: antenatal diagnosis. (2939090)
1986
40
Increased acinar complexity with polyhydramnios. (2945174)
1986
41
Case 8. Enteric duplication cyst of duodenum: cause of polyhydramnios in an 18-trisomic male fetus. (3295831)
1986
42
Prenatal appearance of a mesoblastic nephroma associated with polyhydramnios. (2997303)
1985
43
Prenatal diagnosis of chorioangioma associated with polyhydramnios using ultrasound. (3891446)
1985
44
Polyhydramnios and acute renal failure. (7022419)
1980
45
Rhabdomyoma of the heart: case report of a rare cardiac tumor associated with polyhydramnios. (351963)
1978
46
Polyhydramnios and acute renal failure. (330852)
1977
47
Polyhydramnios and omphalocele. (132570)
1976
48
Letter: Polyhydramnios and neonatal renal failure--a possible association with maternal acetaminophen ingestion. (1092825)
1975
49
Polyhydramnios and neonatal hemorrhage in three sisters. A circumvallate placenta syndrome? (4608262)
1974
50
Recurrent acute polyhydramnios. (4904918)
1970

Variations for Polyhydramnios

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Expression for genes affiliated with Polyhydramnios

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyhydramnios

Search GEO for disease gene expression data for Polyhydramnios.

Pathways for genes affiliated with Polyhydramnios

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 51PharmGKB, 30KEGG, 60Thomson Reuters, 53QIAGEN
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Pathways related to Polyhydramnios according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8FGFR3, STRADA, STK11
29.3SLC12A1, CLCNKB, KCNJ1, BSND
38.9AQP1, AQP8, AQP9
4
Show member pathways
8.7AQP3, AQP9, AQP8, AQP1
5
Show member pathways
8.4AQP3, AQP9, AQP8, AQP1, FGFR3
6
Show member pathways
7.4SLC26A3, BSND, CLCNKB, AQP3, AQP9, AQP8

Compounds for genes affiliated with Polyhydramnios

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45Novoseek, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Polyhydramnios according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1pcmbs4510.3AQP1, AQP3
2hgcl24510.3AQP1, AQP3
3silver4510.0AFP, AQP3, AQP1
4gemeprost4510.0OXT, AFP
5mercury459.9AQP3, AQP9, AQP1
6darusentan45 2910.9EDN1, NPPB
7tezosentan459.9EDN1, NPPB
8urodilatin459.8NPPB, EDN1
9trandolapril45 1110.8NPPB, EDN1
10bicarbonate459.8AQP1, NPPB, SLC26A3
11hanp459.8NPPB, EDN1
12furosemide45 61 29 51 24 1114.7SLC12A1, NPPB, BSND
13bosentan45 1110.7EDN1, NPPB
14chlorine45 2410.7BSND, CLCNKB, SLC12A1, SLC26A3
15enalaprilat459.7NPPB, EDN1
16nitrate459.6EDN1, AFP, NPPB
17ammonium459.4AQP8, AQP1, SLC12A1
18sodium nitroprusside459.4EDN1, AQP1, NPPB
19papaverine45 3 1111.4NPPB, EDN1
20paraffin459.4FGFR3, STK11, OXT, AQP1, AFP
21potassium chloride45 1110.3SLC12A1, OXT, EDN1
22dexamethasone45 51 29 1112.3AFP, AQP3, AQP1, NPPB, FGFR3
23fatty acid459.3AFP, HSD17B4, STK11, FH, NPPB
24mannitol45 1110.3OXT, AQP1, AQP9, AQP3
25nitroglycerin45 1110.3NPPB, OXT, EDN1
26urea45 24 1111.3AFP, AQP3, AQP9, AQP1, SLC12A1
27phenylephrine45 29 24 1112.2NPPB, OXT, EDN1
28magnesium45 24 1111.2KCNJ1, CLCNKB, STK11, NPPB, SLC12A1
29threonine459.1AFP, AQP3, STK11, SLC12A1, FGFR3
30hg2+299.1AQP3, AQP9, AQP8, AQP1
31lipid459.1AFP, AQP1, STK11, RAPSN, NPPB, FGFR3
32Water249.1HSD17B4, AQP3, AQP1, FH, NPPB
33glycerol45 24 1111.0AQP3, AQP9, AQP8, AQP1
34potassium45 24 1111.0BSND, KCNJ1, AFP, CLCNKB, AQP1, RAPSN
35epinephrine45 24 1111.0EDN1, AFP, OXT, NPPB
36hydrogen45 2410.0AFP, AQP1, FH, NPPB
37chloride458.9BSND, KCNJ1, CLCNKB, AQP3, AQP1, SLC12A1
38estradiol45 24 1110.9NPPB, OXT, HSD17B4, AFP
39lactate458.7AFP, AQP9, OXT, FH, NPPB
40glucose458.7AFP, AQP3, AQP9, AQP1, STK11, FH
41serine458.5KCNJ1, AFP, AQP1, OXT, STK11, NPPB
42arginine458.5EDN1, KCNJ1, AQP1, OXT, NPPB, FGFR3
43nacl458.5SLC26A3, BSND, KCNJ1, AFP, CLCNKB, AQP1
44pge2458.5SLC12A1, NPPB, OXT, EDN1
45vegf458.4EDN1, AFP, AQP1, OXT, STK11, NPPB
46nitric oxide45 24 1110.3EDN1, AQP1, OXT, NPPB, SLC12A1
47creatinine458.3EDN1, AFP, AQP3, AQP1, OXT, FH
48forskolin45 51 1110.1AQP3, AQP8, AQP1, OXT, NPPB, SLC12A1
49sodium45 249.0EDN1, BSND, KCNJ1, AFP, CLCNKB, AQP1
50calcium45 51 24 1110.3EDN1, BSND, AFP, CLCNKB, AQP1, OXT

GO Terms for genes affiliated with Polyhydramnios

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16Gene Ontology
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Cellular components related to Polyhydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.1AQP1, AQP9, AQP3, BSND
2integral component of plasma membraneGO:0058878.2CLCNKB, AQP9, AQP8, AQP1, FGFR3, BSND
3plasma membraneGO:0058866.6BSND, KCNJ1, CLCNKB, AQP3, AQP9, AQP8

Biological processes related to Polyhydramnios according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1tissue homeostasisGO:00189410.0STK11, KCNJ1
2nitric oxide transportGO:03018510.0EDN1, AQP1
3cGMP biosynthetic processGO:00618210.0NPPB, AQP1
4odontogenesisGO:04247610.0AQP1, AQP3
5glycerol transportGO:01579310.0AQP1, AQP9
6activation of protein kinase activityGO:03214710.0STRADA, STK11
7insulin receptor signaling pathwayGO:0082869.9FGFR3, STRADA, STK11
8potassium ion transportGO:0068139.8KCNJ1, AQP1, SLC12A1
9chloride transmembrane transportGO:19024769.7SLC26A3, SLC12A1, BSND
10body fluid secretionGO:0075899.7NPPB, EDN1
11positive regulation of urine volumeGO:0358109.6EDN1, NPPB
12canalicular bile acid transportGO:0157229.4AQP8, AQP9
13regulation of sensory perception of painGO:0519309.3EDN1, OXT
14ion transmembrane transportGO:0342209.3SLC12A1, CLCNKB, BSND
15positive regulation of renal sodium excretionGO:0358159.2NPPB, OXT, EDN1
16excretionGO:0075889.2SLC26A3, AQP9, AQP3, CLCNKB, KCNJ1
17water transportGO:0068339.0AQP1, AQP8, AQP9, AQP3
18cellular response to cAMPGO:0713208.9AQP9, AQP8, AQP1, SLC26A3
19transportGO:0068108.3AFP, CLCNKB, AQP3, AQP9, AQP8, SLC12A1
20transmembrane transportGO:0550857.8BSND, CLCNKB, AQP3, AQP9, AQP8, AQP1

Molecular functions related to Polyhydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase activator activityGO:03029510.1STRADA, STK11
2water transmembrane transporter activityGO:0053729.4AQP1, AQP9
3water channel activityGO:0152508.6AQP1, AQP8, AQP9, AQP3

Products for genes affiliated with Polyhydramnios

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Sources for Polyhydramnios

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet