MCID: PLY012
MIFTS: 49

Polyhydramnios malady

Summaries for Polyhydramnios

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Polyhydramnios (polyhydramnion, hydramnios, polyhydramnios) is a medical condition describing an excess... more...

MalaCards: Polyhydramnios is related to oligohydramnios and diabetes insipidus. An important gene associated with Polyhydramnios is STRADA (STE20-related kinase adaptor alpha), and among its related pathways are IRS-related events and Diuretics Pathway, Pharmacodynamics. The compounds gemeprost and pcmbs have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and lung, and related mouse phenotypes are digestive/alimentary and renal/urinary system.

Disease Ontology:8 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

Aliases & Classifications for Polyhydramnios

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Polyhydramnios

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17GeneCards, 18GeneDecks
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Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1oligohydramnios30.7AQP8, OXT, AFP
2diabetes insipidus29.7OXT
3nephrogenic diabetes insipidus29.7AQP1, OXT
4bartter disease29.7BSND, KCNJ1, CLCNKB
5chorioangioma10.3
6twin-to-twin transfusion syndrome10.1
7cervicitis10.1
8congenital mesoblastic nephroma10.1
9myotonic dystrophy10.1
10hydronephrosis10.0
11cerebritis10.0
12costello syndrome10.0
13congenital diaphragmatic hernia10.0
14ovarian cyst10.0
15nephrolithiasis10.0CLCNKB
16testicular germ cell tumor10.0FGFR3, STK11
17hydrarthrosis10.0AQP9
18edwards syndrome10.0AFP
19cystic lymphangioma10.0AFP
20hydrocephalus10.0AQP1, AFP
21bartter syndrome type 310.0CLCNKB, KCNJ1
22gitelman syndrome10.0CLCNKB, BSND, KCNJ1
23hypokalemia10.0CLCNKB, KCNJ1, BSND
24cystic fibrosis10.0SLC26A3, AQP3, AQP1, KCNJ1
25pseudohypoaldosteronism10.0
26hypercalcemia10.0
27achondrogenesis type ib10.0
28esophagitis10.0
29laryngitis10.0
30chondrodysplasia blomstrand type10.0
31duodenal atresia10.0
32tight skin contracture syndrome, lethal10.0
33multiple pterygium syndrome lethal type10.0
34renal hamartomas nephroblastomatosis and fetal gigantism10.0
35thanatophoric dysplasia type 110.0
36polyhydramnios, megalencephaly, and symptomatic epilepsy10.0
37muscular hypertrophy - hepatomegaly - polyhydramnios10.0
38vacterl association9.8
39smith-lemli-opitz syndrome9.8
40multiple intestinal atresia9.8
41treacher collins syndrome9.8
42rubinstein-taybi syndrome9.8
43hyperuricemia9.8
44congenital epulis9.8
45junctional epidermolysis bullosa9.8
46achondroplasia9.8
47digeorge syndrome9.8
48lissencephaly9.8
49boomerang dysplasia9.8
50distal arthrogryposis9.8

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to polyhydramnios

Clinical Features for Polyhydramnios

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Drugs & Therapeutics for Polyhydramnios

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Polyhydramnios

Drug clinical trials:

Search ClinicalTrials for Polyhydramnios

Search NIH Clinical Center for Polyhydramnios

Search CenterWatch for Polyhydramnios

Genetic Tests for Polyhydramnios

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Anatomical Context for Polyhydramnios

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32MalaCards
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MalaCards organs/tissues related to Polyhydramnios:

32
Placenta, Brain, Lung, Heart, Bone, Kidney, Liver, Fetal lung

Animal Models for Polyhydramnios or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polyhydramnios:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.3OXT, FGFR3, SLC26A3, AQP3, AQP8, STK11
2MP:00053679.0KCNJ1, BSND, STK11, OXT, FGFR3, AQP1
3MP:00053868.6KCNJ1, BSND, STK11, AFP, OXT, FGFR3
4MP:00053978.5KCNJ1, CAMLG, FARSA, BSND, STK11, FGFR3
5MP:00053768.0OXT, AFP, STK11, BSND, KCNJ1, FGFR3
6MP:00107687.9AQP3, KCNJ1, CAMLG, FARSA, BSND, STK11

Publications for Polyhydramnios

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50PubMed
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Articles related to Polyhydramnios:

(show top 50)    (show all 276)
idTitleAuthorsYear
1
Clinical significance of amniotic fluid glucose concentration in polyhydramnios. (21916813)
2012
2
Polyhydramnios with bidirectional fetal ductus arteriosus flow in a fetus with congenital diaphragmatic hernia: case report. (21082541)
2011
3
Apert syndrome associated with upper airway obstruction and gastroesophageal reflux inducing polyhydramnios in the third trimester. (20708539)
2010
4
Peripartum outcomes of high-risk pregnancies complicated by oligo- and polyhydramnios: a prospective longitudinal study. (20492376)
2010
5
The expression of aquaporin 8 and aquaporin 9 in fetal membranes and placenta in term pregnancies complicated by idiopathic polyhydramnios. (20732771)
2010
6
Expression of aquaporin 8 in human fetal membrane and placenta of idiopathic polyhydramnios]. (19563057)
2009
7
Outcome of children born out of pregnancies complicated by unexplained polyhydramnios. (17309542)
2007
8
Paradoxical scalloped placenta with polyhydramnios in twin-twin transfusion syndrome. (17437196)
2007
9
Incidence of fetal malformations in pregnancies complicated by oligo- and polyhydramnios. (12673477)
2003
10
Fetal and neonatal outcomes in twin oligohydramnios-polyhydramnios sequence including cerebral palsy. (12169809)
2002
11
High levels of fetal erythroblasts and fetal extracellular DNA in the peripheral blood of a pregnant woman with idiopathic polyhydramnios: case report. (11038466)
2000
12
Acute recurrent polyhydramnios and amniotic prolactin. (10740211)
2000
13
Polyhydramnios as a sign of fetal pseudohypoaldosteronism. (10760533)
2000
14
Study of 290 cases of polyhydramnios and congenital malformations in a series of 225,669 consecutive births. (15178961)
1999
15
Myotonic dystrophy is a significant cause of idiopathic polyhydramnios. (9790382)
1998
16
Abdomino-amniotic shunting in isolated fetal ascites with polyhydramnios. (9292649)
1997
17
New syndrome: brain malformation, growth retardation, hypokinesia and polyhydramnios in two brothers. (9018412)
1997
18
Bladder visualisation as a prognostic sign in oligohydramnios-polyhydramnios sequence in twin pregnancies treated using therapeutic amniocentesis. (9255086)
1997
19
Prenatal diagnosis of epignathus causing acute polyhydramnios. (8677779)
1996
20
The association between polyhydramnios and preterm delivery. (7651648)
1995
21
Idiopathic polyhydramnios: association with fetal macrosomia. (8284386)
1994
22
Impaired fetal blood gas status in polyhydramnios and its relation to raised amniotic pressure. (8142055)
1994
23
An unusual cause of polyhydramnios: congenital gastric teratoma. (8145962)
1994
24
Frequency of fetal anomalies in sonographically detected polyhydramnios. (8455215)
1993
25
Antenatal diagnosis of tetralogy of Fallot with absent pulmonary valve accompanied by hydrops fetalis and polyhydramnios. (8267864)
1993
26
Polyhydramnios: problems and treatment. (8378802)
1993
27
Polyhydramnios: does reducing the amniotic fluid volume decrease the incidence of prematurity? (1617881)
1992
28
Relation of mild idiopathic polyhydramnios to perinatal outcome. (1738520)
1992
29
Acute recurrent polyhydramnios--management with indomethacin. (1873250)
1991
30
Effect of indomethacin on the fetal ductus arteriosus during treatment of symptomatic polyhydramnios. (2191133)
1990
31
Acute polyhydramnios. (2563707)
1989
32
Congenital difficulties with swallowing and breathing associated with maternal polyhydramnios: neurocristopathy or medullary infarction? (2677115)
1989
33
Polyhydramnios: fetal and neonatal implications. (2686899)
1989
34
Animal model for polyhydramnios. (2644839)
1989
35
Prenatal diagnosis of congenital mesoblastic nephroma in association with polyhydramnios. (2845674)
1988
36
Polyhydramnios: a review. (3118281)
1987
37
Treatment of polyhydramnios with prostaglandin synthetase inhibitor (indomethacin). (3113251)
1987
38
Polyhydramnios and elevated intrauterine pressure during amnioinfusion. (3541615)
1987
39
Ultrasound evaluation of polyhydramnios and twin pregnancy. (3518460)
1986
40
Chronic polyhydramnios is a syndrome with a lactogen receptor defect in the chorion laeve. (2986671)
1985
41
Polyhydramnios associated with fetal limb abnormalities. (6340445)
1983
42
Reversal of polyhydramnios by drainage of a fetal renal cyst. A case report. (6350578)
1983
43
Sonography of polyhydramnios. (7034509)
1982
44
Acute polyhydramnios--a complication of monozygous twin pregnancy. (6992848)
1980
45
Acute polyhydramnios--a complication of monozygous twin pregnancy. (389280)
1979
46
Polyhydramnios associated with congenital pancreatic cysts and asphyxiating thoracic dysplasia. A case report. (384563)
1979
47
Rhabdomyoma of the heart: case report of a rare cardiac tumor associated with polyhydramnios. (351963)
1978
48
A new method for pregnancy termination in polyhydramnios. (364919)
1978
49
Decreased fetal movements and polyhydramnios. (345732)
1978
50
The amniotic fluid. II. Polyhydramnios and oligohydramnios. (347047)
1977

Genetic Variations for Polyhydramnios

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Expression for genes affiliated with Polyhydramnios

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyhydramnios

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Pathways for genes affiliated with Polyhydramnios

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53Reactome, 49PharmGKB, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Polyhydramnios

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Polyhydramnios according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1gemeprost4410.3OXT, AFP
2pcmbs4410.3AQP1, AQP3
3hgcl24410.3AQP3, AQP1
4mercury4410.1AQP1, AQP3, AQP9
5dids44 2811.1CLCNKB, AQP1
6silver4410.0AFP, AQP1, AQP3
7hg2+289.9AQP9, AQP8, AQP3, AQP1
8urea44 11 2411.9AFP, AQP1, AQP3, AQP9
9chlorine44 2410.9SLC26A3, CLCNKB, BSND
10mannitol44 1110.9AQP9, AQP3, AQP1, OXT
11paraffin449.8AQP1, FGFR3, OXT, AFP, STK11
12glycerol44 11 2411.8AQP1, AQP3, AQP8, AQP9
13potassium44 11 2411.7KCNJ1, BSND, AFP, CLCNKB, RAPSN, AQP1
14sodium44 2410.7KCNJ1, BSND, AFP, CLCNKB, RAPSN, AQP1
15nacl449.7KCNJ1, BSND, AFP, CLCNKB, SLC26A3, AQP1
16chloride449.7KCNJ1, BSND, CLCNKB, SLC26A3, AQP1, AQP3
17vegf449.6AFP, OXT, FGFR3, AQP1, STK11
18forskolin44 49 1111.4AQP8, AQP3, AQP1, OXT
19calcium44 49 11 2412.0CAMLG, BSND, STK11, AFP, OXT, FGFR3

GO Terms for genes affiliated with Polyhydramnios

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16Gene Ontology
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Cellular components related to Polyhydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.5AQP9, AQP3, AQP1, BSND
2integral to plasma membraneGO:0058879.3FGFR3, CLCNKB, AQP1, AQP8, AQP9, BSND
3plasma membraneGO:0058868.2KCNJ1, BSND, FGFR3, CLCNKB, RAPSN, SLC26A3

Biological processes related to Polyhydramnios according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1glycerol transportGO:01579310.0AQP9, AQP1
2insulin receptor signaling pathwayGO:00828610.0FGFR3, STRADA, STK11
3tissue homeostasisGO:00189410.0STK11, KCNJ1
4canalicular bile acid transportGO:01572210.0AQP8, AQP9
5activation of protein kinase activityGO:0321479.9STK11, STRADA
6water transportGO:0068339.8AQP1, AQP3, AQP8, AQP9
7cellular response to cAMPGO:0713209.7AQP9, AQP8, AQP1, SLC26A3
8excretionGO:0075889.6AQP9, AQP3, SLC26A3, CLCNKB, KCNJ1
9transportGO:0068109.6AQP9, AQP8, AQP3, CLCNKB, AFP
10transmembrane transportGO:0550859.2BSND, CLCNKB, SLC26A3, AQP1, AQP3, AQP8

Molecular functions related to Polyhydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase activator activityGO:03029510.2STRADA, STK11
2water transmembrane transporter activityGO:0053729.7AQP9, AQP1
3water channel activityGO:0152509.5AQP9, AQP8, AQP3, AQP1

Products for genes affiliated with Polyhydramnios

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polyhydramnios

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet