MCID: PLY012
MIFTS: 54

Polyhydramnios malady

Fetal diseases category
Download this MalaCard

Summaries for Polyhydramnios

About this section


Fully expand this MalaCard
Wikipedia:65 Polyhydramnios (polyhydramnion, hydramnios, polyhydramnios) is a medical condition describing an excess... more...

MalaCards based summary: Polyhydramnios is related to oligohydramnios and diabetes insipidus. An important gene associated with Polyhydramnios is STRADA (STE20-related kinase adaptor alpha), and among its related pathways are Insulin receptor signalling cascade and Diuretics Pathway, Pharmacodynamics. The compounds pcmbs and hgcl2 have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and lung, and related mouse phenotypes are hearing/vestibular/ear and nervous system.

Disease Ontology:8 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

Aliases & Classifications for Polyhydramnios

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Polyhydramnios, Aliases & Descriptions:

Name: Polyhydramnios 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


External Ids:

Disease Ontology8 DOID:8488
ICD9CM27 657, 657.0
MeSH34 D006831
ICD1025 O40

Related Diseases for Polyhydramnios

About this section

Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1oligohydramnios31.3AFP, AQP8, OXT
2diabetes insipidus30.6OXT
3nephrogenic diabetes insipidus30.1AQP3, SLC12A1
4bartter disease29.7BSND, KCNJ1, CLCNKB, SLC12A1
5testicular germ cell tumor10.4STK11, FGFR3
6hepatorenal syndrome10.3EDN1
7chorioangioma10.3
8myoma10.3FH, OXT
9twin twin transfusion syndrome10.3
10hyperaldosteronism10.2CLCNKB, KCNJ1
11meconium aspiration syndrome10.2EDN1, OXT
12hydrocephalus10.2AFP, AQP1
13twin-to-twin transfusion syndrome10.2
14mesoblastic nephroma10.2
15cervicitis10.2
16congenital mesoblastic nephroma10.2
17myotonic dystrophy10.2
18teratoma10.2
19peutz-jeghers syndrome10.2STRADA, STK11
20bartter syndrome, type 210.1SLC12A1, KCNJ1
21costello syndrome10.1
22hydronephrosis10.1
23cerebritis10.1
24congenital diaphragmatic hernia10.1
25ovarian cyst10.1
26hydrops fetalis10.1
27polyhydramnios, megalencephaly, and symptomatic epilepsy10.1
28bartter syndrome type 310.1SLC12A1, CLCNKB, KCNJ1
29nephrocalcinosis10.1SLC12A1, CLCNKB, KCNJ1
30sensorineural hearing loss10.0SLC12A1, KCNJ1, BSND
31pre-eclampsia10.0OXT, AFP, EDN1
32pseudohypoaldosteronism10.0
33hypercalcemia10.0
34achondrogenesis type ia10.0
35esophagitis10.0
36laryngitis10.0
37chondrodysplasia blomstrand type10.0
38diffuse neonatal hemangiomatosis10.0
39duodenal atresia10.0
40multiple pterygium syndrome lethal type10.0
41renal hamartomas nephroblastomatosis and fetal gigantism10.0
42thanatophoric dysplasia type 110.0
43tight skin contracture syndrome, lethal10.0
44omphalocele10.0
45muscular hypertrophy - hepatomegaly - polyhydramnios10.0
46cor pulmonale10.0EDN1, NPPB
47cystic fibrosis10.0SLC26A3, AQP1, AQP3, KCNJ1
48gitelman syndrome10.0BSND, KCNJ1, CLCNKB, SLC12A1
49hypokalemia10.0BSND, KCNJ1, CLCNKB, SLC12A1
50idiopathic edema9.9EDN1, AQP1, NPPB

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to polyhydramnios

Symptoms for Polyhydramnios

About this section

Drugs & Therapeutics for Polyhydramnios

About this section

Drug clinical trials:

Search ClinicalTrials for Polyhydramnios

Search NIH Clinical Center for Polyhydramnios

Genetic Tests for Polyhydramnios

About this section

Anatomical Context for Polyhydramnios

About this section

MalaCards organs/tissues related to Polyhydramnios:

32
Placenta, Brain, Lung, Heart, Bone, Kidney, Liver, Fetal lung

Animal Models for Polyhydramnios or affiliated genes

About this section

Publications for Polyhydramnios

About this section

Articles related to Polyhydramnios:

(show top 50)    (show all 282)
idTitleAuthorsYear
1
Ovine fetal swallowing responses to polyhydramnios. (24760530)
2014
2
Fetal swallowing as a protective mechanism against oligohydramnios and polyhydramnios in late gestation sheep. (22872543)
2013
3
Polyhydramnios: a warning sign in the prenatal ultrasound diagnosis of foetal malformation? (23403339)
2013
4
Polyhydramnios with bidirectional fetal ductus arteriosus flow in a fetus with congenital diaphragmatic hernia: case report. (21082541)
2011
5
The amnioscope strikes back as a useful device for pinhole amniotomy in the management of polyhydramnios. (23705096)
2011
6
Successful management of a high-risk pregnancy with polyhydramnios, IUGR and recurrent pregnancy loss in a chronic renal failure patient: a case report. (21485740)
2011
7
Expression of aquaporin 8 in human fetal membrane and placenta of idiopathic polyhydramnios]. (19563057)
2009
8
Clinical application of fetal urine production rate in unexplained polyhydramnios. (19830790)
2009
9
Expression of aquaporin 3 and aquaporin 9 in placenta and fetal membrane with idiopathic polyhydramnios.]. (20193419)
2009
10
Polyhydramnios. Risk factors and outcome. (18246237)
2008
11
Acute recurrent polyhydramnios: a combination of amniocenteses and NSAID may be curative rather than palliative. (17228156)
2007
12
Steady-state levels of aquaporin 1 mRNA expression are increased in idiopathic polyhydramnios. (16522429)
2006
13
Clinical features of polyhydramnios associated with fetal anomalies. (17096817)
2006
14
Use of continuous fluid drainage for severe polyhydramnios due to twin to twin transfusion syndrome. (11491373)
2001
15
Increased urinary flow without development of polyhydramnios in response to prolonged hypoxia in the ovine fetus. (11303213)
2001
16
High levels of fetal erythroblasts and fetal extracellular DNA in the peripheral blood of a pregnant woman with idiopathic polyhydramnios: case report. (11038466)
2000
17
Study of 290 cases of polyhydramnios and congenital malformations in a series of 225,669 consecutive births. (15178961)
1999
18
Polyhydramnios as a first prenatal symptom of non-ketotic hyperglycinaemia. (9742581)
1998
19
Myotonic dystrophy is a significant cause of idiopathic polyhydramnios. (9790382)
1998
20
Abdomino-amniotic shunting in isolated fetal ascites with polyhydramnios. (9292649)
1997
21
New syndrome: brain malformation, growth retardation, hypokinesia and polyhydramnios in two brothers. (9018412)
1997
22
Polyhydramnios is an independent risk factor for perinatal mortality and intrapartum morbidity in preterm delivery. (9031919)
1996
23
Is polyhydramnios in an ultrasonographically normal fetus an indication for genetic evaluation? (7503195)
1995
24
Polyhydramnios: ultrasonic detection of fetal and maternal conditions. (7933915)
1994
25
Significance of idiopathic midtrimester polyhydramnios. (7945628)
1994
26
Fetal renal artery flow velocity waveforms in normal pregnancies and pregnancies complicated by polyhydramnios and oligohydramnios. (8459967)
1993
27
Maternal smoking and the risk of polyhydramnios. (1739142)
1992
28
Reduction in the middle cerebral artery pulsatility index after decompression of polyhydramnios in twin gestation. (1418139)
1992
29
The natural history of oligohydramnios/polyhydramnios sequence in monochorionic diamniotic twins. (12796928)
1992
30
Indomethacin for the treatment of polyhydramnios: a case of constriction of the ductus arteriosus. (1445137)
1992
31
Pathophysiology of congenital diaphragmatic hernia: I. Renal enlargement suggests feedback modulation by pulmonary derived renotropins--a unifying hypothesis to explain pulmonary hypoplasia, polyhydramnios, and renal enlargement in the fetus/newborn with congenital diaphragmatic hernia. (2191107)
1990
32
Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios. (2405319)
1990
33
Acute polyhydramnios in twin pregnancy. A retrospective study with special reference to therapeutic amniocentesis. (2244460)
1990
34
Maternal lithium therapy and polyhydramnios. (2199873)
1990
35
Antenatal evaluation of upper gastrointestinal dilatation complicated by non-immune hydrops fetalis and polyhydramnios. (2697734)
1989
36
Acute polyhydramnios. (2563707)
1989
37
Prenatal diagnosis of congenital mesoblastic nephroma in association with polyhydramnios. (2845674)
1988
38
Treacher-Collins syndrome: an association with polyhydramnios. (3141842)
1988
39
Placental chorioangioma, an unusual cause of polyhydramnios: antenatal diagnosis. (2939090)
1986
40
Increased acinar complexity with polyhydramnios. (2945174)
1986
41
Case 8. Enteric duplication cyst of duodenum: cause of polyhydramnios in an 18-trisomic male fetus. (3295831)
1986
42
Prenatal appearance of a mesoblastic nephroma associated with polyhydramnios. (2997303)
1985
43
Prenatal diagnosis of chorioangioma associated with polyhydramnios using ultrasound. (3891446)
1985
44
Polyhydramnios and acute renal failure. (7022419)
1980
45
Rhabdomyoma of the heart: case report of a rare cardiac tumor associated with polyhydramnios. (351963)
1978
46
Polyhydramnios and acute renal failure. (330852)
1977
47
Polyhydramnios and omphalocele. (132570)
1976
48
Letter: Polyhydramnios and neonatal renal failure--a possible association with maternal acetaminophen ingestion. (1092825)
1975
49
Polyhydramnios and neonatal hemorrhage in three sisters. A circumvallate placenta syndrome? (4608262)
1974
50
Recurrent acute polyhydramnios. (4904918)
1970

Variations for Polyhydramnios

About this section

Expression for genes affiliated with Polyhydramnios

About this section
Expression patterns in normal tissues for genes affiliated with Polyhydramnios

Search GEO for disease gene expression data for Polyhydramnios.

Pathways for genes affiliated with Polyhydramnios

About this section

Pathways related to Polyhydramnios according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8FGFR3, STRADA, STK11
29.3SLC12A1, CLCNKB, KCNJ1, BSND
38.9AQP1, AQP8, AQP9
4
Show member pathways
8.7AQP3, AQP9, AQP8, AQP1
5
Show member pathways
8.4AQP3, AQP9, AQP8, AQP1, FGFR3
6
Show member pathways
7.4SLC26A3, BSND, CLCNKB, AQP3, AQP9, AQP8

Compounds for genes affiliated with Polyhydramnios

About this section

Compounds related to Polyhydramnios according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1pcmbs4410.3AQP1, AQP3
2hgcl24410.3AQP1, AQP3
3silver4410.0AFP, AQP3, AQP1
4gemeprost4410.0OXT, AFP
5mercury449.9AQP3, AQP9, AQP1
6darusentan44 2810.9EDN1, NPPB
7tezosentan449.9EDN1, NPPB
8urodilatin449.8NPPB, EDN1
9trandolapril44 1110.8NPPB, EDN1
10bicarbonate449.8AQP1, NPPB, SLC26A3
11hanp449.8NPPB, EDN1
12furosemide44 61 28 50 24 1114.7SLC12A1, NPPB, BSND
13bosentan44 1110.7EDN1, NPPB
14chlorine44 2410.7BSND, CLCNKB, SLC12A1, SLC26A3
15enalaprilat449.7NPPB, EDN1
16nitrate449.6EDN1, AFP, NPPB
17ammonium449.4AQP8, AQP1, SLC12A1
18sodium nitroprusside449.4EDN1, AQP1, NPPB
19papaverine44 2 1111.4NPPB, EDN1
20paraffin449.4FGFR3, STK11, OXT, AQP1, AFP
21potassium chloride44 1110.3SLC12A1, OXT, EDN1
22dexamethasone44 50 28 1112.3AFP, AQP3, AQP1, NPPB, FGFR3
23fatty acid449.3AFP, HSD17B4, STK11, FH, NPPB
24mannitol44 1110.3OXT, AQP1, AQP9, AQP3
25nitroglycerin44 1110.3NPPB, OXT, EDN1
26urea44 24 1111.3AFP, AQP3, AQP9, AQP1, SLC12A1
27phenylephrine44 28 24 1112.2NPPB, OXT, EDN1
28magnesium44 24 1111.2KCNJ1, CLCNKB, STK11, NPPB, SLC12A1
29threonine449.1AFP, AQP3, STK11, SLC12A1, FGFR3
30hg2+289.1AQP3, AQP9, AQP8, AQP1
31lipid449.1AFP, AQP1, STK11, RAPSN, NPPB, FGFR3
32Water249.1HSD17B4, AQP3, AQP1, FH, NPPB
33glycerol44 24 1111.0AQP3, AQP9, AQP8, AQP1
34potassium44 24 1111.0BSND, KCNJ1, AFP, CLCNKB, AQP1, RAPSN
35epinephrine44 24 1111.0EDN1, AFP, OXT, NPPB
36hydrogen44 2410.0AFP, AQP1, FH, NPPB
37chloride448.9BSND, KCNJ1, CLCNKB, AQP3, AQP1, SLC12A1
38estradiol44 24 1110.9NPPB, OXT, HSD17B4, AFP
39lactate448.7AFP, AQP9, OXT, FH, NPPB
40glucose448.7AFP, AQP3, AQP9, AQP1, STK11, FH
41serine448.5KCNJ1, AFP, AQP1, OXT, STK11, NPPB
42arginine448.5EDN1, KCNJ1, AQP1, OXT, NPPB, FGFR3
43nacl448.5SLC26A3, BSND, KCNJ1, AFP, CLCNKB, AQP1
44pge2448.5SLC12A1, NPPB, OXT, EDN1
45vegf448.4EDN1, AFP, AQP1, OXT, STK11, NPPB
46nitric oxide44 24 1110.3EDN1, AQP1, OXT, NPPB, SLC12A1
47creatinine448.3EDN1, AFP, AQP3, AQP1, OXT, FH
48forskolin44 50 1110.1AQP3, AQP8, AQP1, OXT, NPPB, SLC12A1
49sodium44 249.0EDN1, BSND, KCNJ1, AFP, CLCNKB, AQP1
50calcium44 50 24 1110.3EDN1, BSND, AFP, CLCNKB, AQP1, OXT

GO Terms for genes affiliated with Polyhydramnios

About this section

Cellular components related to Polyhydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.1AQP1, AQP9, AQP3, BSND
2integral component of plasma membraneGO:0058878.2CLCNKB, AQP9, AQP8, AQP1, FGFR3, BSND
3plasma membraneGO:0058866.6BSND, KCNJ1, CLCNKB, AQP3, AQP9, AQP8

Biological processes related to Polyhydramnios according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1tissue homeostasisGO:00189410.0STK11, KCNJ1
2nitric oxide transportGO:03018510.0EDN1, AQP1
3cGMP biosynthetic processGO:00618210.0NPPB, AQP1
4odontogenesisGO:04247610.0AQP1, AQP3
5glycerol transportGO:01579310.0AQP1, AQP9
6activation of protein kinase activityGO:03214710.0STRADA, STK11
7insulin receptor signaling pathwayGO:0082869.9FGFR3, STRADA, STK11
8potassium ion transportGO:0068139.8KCNJ1, AQP1, SLC12A1
9chloride transmembrane transportGO:19024769.7SLC26A3, SLC12A1, BSND
10body fluid secretionGO:0075899.7NPPB, EDN1
11positive regulation of urine volumeGO:0358109.6EDN1, NPPB
12canalicular bile acid transportGO:0157229.4AQP8, AQP9
13regulation of sensory perception of painGO:0519309.3EDN1, OXT
14ion transmembrane transportGO:0342209.3SLC12A1, CLCNKB, BSND
15positive regulation of renal sodium excretionGO:0358159.2NPPB, OXT, EDN1
16excretionGO:0075889.2SLC26A3, AQP9, AQP3, CLCNKB, KCNJ1
17water transportGO:0068339.0AQP1, AQP8, AQP9, AQP3
18cellular response to cAMPGO:0713208.9AQP9, AQP8, AQP1, SLC26A3
19transportGO:0068108.3AFP, CLCNKB, AQP3, AQP9, AQP8, SLC12A1
20transmembrane transportGO:0550857.8BSND, CLCNKB, AQP3, AQP9, AQP8, AQP1

Molecular functions related to Polyhydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase activator activityGO:03029510.1STRADA, STK11
2water transmembrane transporter activityGO:0053729.4AQP1, AQP9
3water channel activityGO:0152508.6AQP1, AQP8, AQP9, AQP3

Products for genes affiliated with Polyhydramnios

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Polyhydramnios

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet