Aliases & Classifications for Polyhydramnios

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 25ICD10
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Polyhydramnios, Aliases & Descriptions:

Name: Polyhydramnios 9 11 43 60


Classifications:



External Ids:

Disease Ontology9 DOID:8488
MeSH33 D006831
ICD9CM27 657.0, 657
ICD1025 O40

Summaries for Polyhydramnios

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Wikipedia:63 Polyhydramnios (polyhydramnion, hydramnios, polyhydramnios) is a medical condition describing an excess... more...

MalaCards based summary: Polyhydramnios is related to oligohydramnios and diabetes insipidus. An important gene associated with Polyhydramnios is STRADA (STE20-related kinase adaptor alpha), and among its related pathways are Insulin receptor signalling cascade and Diuretics Pathway, Pharmacodynamics. The compounds pcmbs and hgcl2 have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and heart, and related mouse phenotypes are hearing/vestibular/ear and nervous system.

Disease Ontology:9 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

Related Diseases for Polyhydramnios

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Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 221)
idRelated DiseaseScoreTop Affiliating Genes
1oligohydramnios31.2AFP, AQP8, OXT
2diabetes insipidus30.5OXT
3antenatal bartter syndrome30.0KCNJ1, SLC12A1
4bartter disease29.7CLCNKB, KCNJ1, BSND, SLC12A1
5testicular germ cell tumor10.4FGFR3, STK11
6chorioangioma10.3
7hepatorenal syndrome10.3EDN1
8myoma10.3FH, OXT
9hyperaldosteronism10.2CLCNKB, KCNJ1
10polyhydramnios, megalencephaly, and symptomatic epilepsy10.2
11meconium aspiration syndrome10.2EDN1, OXT
12hydrocephalus10.2AQP1, AFP
13diabetes insipidus, nephrogenic10.2AQP3, SLC12A1
14thanatophoric dysplasia, type i10.2
15costello syndrome10.2
16mesoblastic nephroma10.2
17peutz-jeghers syndrome10.1STRADA, STK11
18restrictive dermopathy, lethal10.1
19multiple pterygium syndrome, lethal type10.1
20perlman syndrome10.1
21chondrodysplasia, blomstrand type10.1
22cervicitis10.1
23congenital mesoblastic nephroma10.1
24myotonic dystrophy10.1
25chromosome 1q duplication10.1
26teratoma10.1
27schneckenbecken dysplasia10.1
28peters anomaly10.1
29intestinal atresia, multiple10.1
30visceral myopathy10.1
31thanatophoric dysplasia, type ii10.1
32roberts syndrome10.1
33epidermolysis bullosa simplex with pyloric atresia10.1
34achondrogenesis, type ia10.1
35bohring-opitz syndrome10.1
36hydrolethalus syndrome10.1
37rubinstein-taybi syndrome10.1
38neu-laxova syndrome110.1
39achondrogenesis ib10.1
40bamforth-lazarus syndrome10.1
41achondrogenesis, type ii or hypochondrogenesis10.1
42twin-to-twin transfusion syndrome10.1
43hydronephrosis10.1
44cerebritis10.1
45distal arthrogryposis10.1
46ovarian cyst10.1
47diffuse neonatal hemangiomatosis10.1
48duodenal atresia10.1
49hec syndrome10.1
50hydrops fetalis10.1

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to polyhydramnios

Symptoms for Polyhydramnios

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Drugs & Therapeutics for Polyhydramnios

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Drug clinical trials:

Search ClinicalTrials for Polyhydramnios

Search NIH Clinical Center for Polyhydramnios

Genetic Tests for Polyhydramnios

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Anatomical Context for Polyhydramnios

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MalaCards organs/tissues related to Polyhydramnios:

31
Placenta, Brain, Heart, Lung, Bone, Kidney, Liver, Fetal lung

Animal Models for Polyhydramnios or affiliated genes

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Publications for Polyhydramnios

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Articles related to Polyhydramnios:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Questions about and speculations on the incidence of idiopathic polyhydramnios by fetal gender. (25786637)
2015
2
Ovine fetal swallowing responses to polyhydramnios. (24760530)
2014
3
Fetal swallowing as a protective mechanism against oligohydramnios and polyhydramnios in late gestation sheep. (22872543)
2013
4
Polyhydramnios: a warning sign in the prenatal ultrasound diagnosis of foetal malformation? (23403339)
2013
5
Polyhydramnios with bidirectional fetal ductus arteriosus flow in a fetus with congenital diaphragmatic hernia: case report. (21082541)
2011
6
The amnioscope strikes back as a useful device for pinhole amniotomy in the management of polyhydramnios. (23705096)
2011
7
Successful management of a high-risk pregnancy with polyhydramnios, IUGR and recurrent pregnancy loss in a chronic renal failure patient: a case report. (21485740)
2011
8
Expression of aquaporin 8 in human fetal membrane and placenta of idiopathic polyhydramnios]. (19563057)
2009
9
Clinical application of fetal urine production rate in unexplained polyhydramnios. (19830790)
2009
10
Expression of aquaporin 3 and aquaporin 9 in placenta and fetal membrane with idiopathic polyhydramnios.]. (20193419)
2009
11
Polyhydramnios. Risk factors and outcome. (18246237)
2008
12
Acute recurrent polyhydramnios: a combination of amniocenteses and NSAID may be curative rather than palliative. (17228156)
2007
13
Outcome of children born out of pregnancies complicated by unexplained polyhydramnios. (17309542)
2007
14
Steady-state levels of aquaporin 1 mRNA expression are increased in idiopathic polyhydramnios. (16522429)
2006
15
Clinical features of polyhydramnios associated with fetal anomalies. (17096817)
2006
16
Increased urinary flow without development of polyhydramnios in response to prolonged hypoxia in the ovine fetus. (11303213)
2001
17
High levels of fetal erythroblasts and fetal extracellular DNA in the peripheral blood of a pregnant woman with idiopathic polyhydramnios: case report. (11038466)
2000
18
Study of 290 cases of polyhydramnios and congenital malformations in a series of 225,669 consecutive births. (15178961)
1999
19
Polyhydramnios as a first prenatal symptom of non-ketotic hyperglycinaemia. (9742581)
1998
20
Myotonic dystrophy is a significant cause of idiopathic polyhydramnios. (9790382)
1998
21
Abdomino-amniotic shunting in isolated fetal ascites with polyhydramnios. (9292649)
1997
22
New syndrome: brain malformation, growth retardation, hypokinesia and polyhydramnios in two brothers. (9018412)
1997
23
Polyhydramnios is an independent risk factor for perinatal mortality and intrapartum morbidity in preterm delivery. (9031919)
1996
24
Is polyhydramnios in an ultrasonographically normal fetus an indication for genetic evaluation? (7503195)
1995
25
Polyhydramnios: ultrasonic detection of fetal and maternal conditions. (7933915)
1994
26
Significance of idiopathic midtrimester polyhydramnios. (7945628)
1994
27
Fetal renal artery flow velocity waveforms in normal pregnancies and pregnancies complicated by polyhydramnios and oligohydramnios. (8459967)
1993
28
Maternal smoking and the risk of polyhydramnios. (1739142)
1992
29
Reduction in the middle cerebral artery pulsatility index after decompression of polyhydramnios in twin gestation. (1418139)
1992
30
The natural history of oligohydramnios/polyhydramnios sequence in monochorionic diamniotic twins. (12796928)
1992
31
Indomethacin for the treatment of polyhydramnios: a case of constriction of the ductus arteriosus. (1445137)
1992
32
Pathophysiology of congenital diaphragmatic hernia: I. Renal enlargement suggests feedback modulation by pulmonary derived renotropins--a unifying hypothesis to explain pulmonary hypoplasia, polyhydramnios, and renal enlargement in the fetus/newborn with congenital diaphragmatic hernia. (2191107)
1990
33
Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios. (2405319)
1990
34
Acute polyhydramnios in twin pregnancy. A retrospective study with special reference to therapeutic amniocentesis. (2244460)
1990
35
Maternal lithium therapy and polyhydramnios. (2199873)
1990
36
Antenatal evaluation of upper gastrointestinal dilatation complicated by non-immune hydrops fetalis and polyhydramnios. (2697734)
1989
37
Acute polyhydramnios. (2563707)
1989
38
Prenatal diagnosis of congenital mesoblastic nephroma in association with polyhydramnios. (2845674)
1988
39
Treacher-Collins syndrome: an association with polyhydramnios. (3141842)
1988
40
Placental chorioangioma, an unusual cause of polyhydramnios: antenatal diagnosis. (2939090)
1986
41
Case 8. Enteric duplication cyst of duodenum: cause of polyhydramnios in an 18-trisomic male fetus. (3295831)
1986
42
Prenatal appearance of a mesoblastic nephroma associated with polyhydramnios. (2997303)
1985
43
Prenatal diagnosis of chorioangioma associated with polyhydramnios using ultrasound. (3891446)
1985
44
Polyhydramnios and acute renal failure. (7022419)
1980
45
Rhabdomyoma of the heart: case report of a rare cardiac tumor associated with polyhydramnios. (351963)
1978
46
Polyhydramnios and acute renal failure. (330852)
1977
47
Polyhydramnios and omphalocele. (132570)
1976
48
Letter: Polyhydramnios and neonatal renal failure--a possible association with maternal acetaminophen ingestion. (1092825)
1975
49
Polyhydramnios and neonatal hemorrhage in three sisters. A circumvallate placenta syndrome? (4608262)
1974
50
Recurrent acute polyhydramnios. (4904918)
1970

Variations for Polyhydramnios

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Expression for genes affiliated with Polyhydramnios

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Search GEO for disease gene expression data for Polyhydramnios.

Pathways for genes affiliated with Polyhydramnios

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Pathways related to Polyhydramnios according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8FGFR3, STRADA, STK11
29.3SLC12A1, CLCNKB, KCNJ1, BSND
38.9AQP1, AQP8, AQP9
4
Show member pathways
8.7AQP3, AQP9, AQP8, AQP1
5
Show member pathways
8.4AQP3, AQP9, AQP8, AQP1, FGFR3
6
Show member pathways
7.4SLC26A3, BSND, CLCNKB, AQP3, AQP9, AQP8

Compounds for genes affiliated with Polyhydramnios

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Compounds related to Polyhydramnios according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1pcmbs4310.3AQP1, AQP3
2hgcl24310.3AQP1, AQP3
3silver4310.0AFP, AQP3, AQP1
4gemeprost4310.0OXT, AFP
5mercury439.9AQP3, AQP9, AQP1
6darusentan43 2810.9EDN1, NPPB
7tezosentan439.9EDN1, NPPB
8urodilatin439.8NPPB, EDN1
9trandolapril43 1210.8NPPB, EDN1
10bicarbonate439.8NPPB, SLC26A3, AQP1
11hanp439.8NPPB, EDN1
12furosemide43 59 28 49 24 1214.7NPPB, BSND, SLC12A1
13bosentan43 1210.7NPPB, EDN1
14chlorine43 2410.7SLC12A1, CLCNKB, BSND, SLC26A3
15enalaprilat439.7EDN1, NPPB
16nitrate439.6EDN1, AFP, NPPB
17ammonium439.4SLC12A1, AQP1, AQP8
18sodium nitroprusside439.4NPPB, AQP1, EDN1
19papaverine43 2 1211.4NPPB, EDN1
20paraffin439.4OXT, AFP, AQP1, STK11, FGFR3
21potassium chloride43 1210.3EDN1, OXT, SLC12A1
22dexamethasone43 49 28 1212.3AQP3, FGFR3, AFP, AQP1, NPPB
23fatty acid439.3AFP, NPPB, HSD17B4, STK11, FH
24mannitol43 1210.3OXT, AQP3, AQP1, AQP9
25nitroglycerin43 1210.3NPPB, EDN1, OXT
26urea43 24 1211.3AQP1, AQP3, AQP9, SLC12A1, AFP
27phenylephrine43 28 24 1212.2EDN1, NPPB, OXT
28magnesium43 24 1211.2STK11, CLCNKB, SLC12A1, KCNJ1, NPPB
29threonine439.1AQP3, AFP, STK11, SLC12A1, FGFR3
30hg2+289.1AQP3, AQP9, AQP8, AQP1
31lipid439.1STK11, RAPSN, AFP, FGFR3, NPPB, AQP1
32Water249.1NPPB, FH, AQP1, AQP3, HSD17B4
33glycerol43 24 1211.0AQP3, AQP1, AQP9, AQP8
34potassium43 24 1211.0AQP1, SLC12A1, RAPSN, BSND, KCNJ1, AFP
35epinephrine43 24 1211.0AFP, EDN1, OXT, NPPB
36hydrogen43 2410.0AFP, NPPB, FH, AQP1
37chloride438.9KCNJ1, CLCNKB, AQP3, AQP1, SLC12A1, SLC26A3
38estradiol43 24 1210.9AFP, HSD17B4, OXT, NPPB
39lactate438.7AFP, NPPB, FH, OXT, AQP9
40glucose438.7AQP9, AQP1, AQP3, AFP, FH, STK11
41serine438.5FGFR3, KCNJ1, NPPB, STK11, OXT, AFP
42arginine438.5EDN1, AQP1, NPPB, KCNJ1, FGFR3, OXT
43nacl438.5SLC26A3, BSND, KCNJ1, AFP, CLCNKB, AQP1
44pge2438.5EDN1, NPPB, SLC12A1, OXT
45vegf438.4NPPB, STK11, OXT, AQP1, AFP, EDN1
46nitric oxide43 24 1210.3EDN1, OXT, SLC12A1, NPPB, AQP1
47creatinine438.3AFP, AQP3, AQP1, OXT, NPPB, FH
48forskolin43 49 1210.1SLC12A1, AQP8, AQP1, AQP3, OXT, NPPB
49sodium43 249.0EDN1, BSND, KCNJ1, AFP, CLCNKB, AQP1
50calcium43 49 24 1210.3AQP1, OXT, STK11, RAPSN, NPPB, FGFR3

GO Terms for genes affiliated with Polyhydramnios

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Cellular components related to Polyhydramnios according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:00163239.1AQP1, AQP9, AQP3, BSND
2integral component of plasma membraneGO:00058878.2CLCNKB, AQP9, AQP8, AQP1, FGFR3, BSND
3plasma membraneGO:00058866.6BSND, KCNJ1, CLCNKB, AQP3, AQP9, AQP8

Biological processes related to Polyhydramnios according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1tissue homeostasisGO:000189410.0STK11, KCNJ1
2nitric oxide transportGO:003018510.0EDN1, AQP1
3cGMP biosynthetic processGO:000618210.0NPPB, AQP1
4odontogenesisGO:004247610.0AQP1, AQP3
5glycerol transportGO:001579310.0AQP1, AQP9
6activation of protein kinase activityGO:003214710.0STRADA, STK11
7insulin receptor signaling pathwayGO:00082869.9FGFR3, STRADA, STK11
8potassium ion transportGO:00068139.8KCNJ1, AQP1, SLC12A1
9chloride transmembrane transportGO:019024769.7SLC26A3, SLC12A1, BSND
10body fluid secretionGO:00075899.7NPPB, EDN1
11positive regulation of urine volumeGO:00358109.6EDN1, NPPB
12canalicular bile acid transportGO:00157229.4AQP8, AQP9
13regulation of sensory perception of painGO:00519309.3EDN1, OXT
14ion transmembrane transportGO:00342209.3SLC12A1, CLCNKB, BSND
15positive regulation of renal sodium excretionGO:00358159.2NPPB, OXT, EDN1
16excretionGO:00075889.2SLC26A3, AQP9, AQP3, CLCNKB, KCNJ1
17water transportGO:00068339.0AQP1, AQP8, AQP9, AQP3
18cellular response to cAMPGO:00713208.9AQP9, AQP8, AQP1, SLC26A3
19transportGO:00068108.3AFP, CLCNKB, AQP3, AQP9, AQP8, SLC12A1
20transmembrane transportGO:00550857.8BSND, CLCNKB, AQP3, AQP9, AQP8, AQP1

Molecular functions related to Polyhydramnios according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein kinase activator activityGO:003029510.1STRADA, STK11
2water transmembrane transporter activityGO:00053729.4AQP1, AQP9
3water channel activityGO:00152508.6AQP1, AQP8, AQP9, AQP3

Products for genes affiliated with Polyhydramnios

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Sources for Polyhydramnios

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet