Aliases & Classifications for Polyhydramnios

MalaCards integrated aliases for Polyhydramnios:

Name: Polyhydramnios 12 28 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8488
ICD10 32 O40
ICD9CM 34 657 657.0
MeSH 41 D006831
NCIt 46 C92848
UMLS 69 C0020224

Summaries for Polyhydramnios

Disease Ontology : 12 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

MalaCards based summary : Polyhydramnios is related to polyhydramnios, megalencephaly, and symptomatic epilepsy and bartter disease, and has symptoms including morning sickness An important gene associated with Polyhydramnios is STRADA (STE20-Related Kinase Adaptor Alpha), and among its related pathways/superpathways are LKB1 signaling events and Diuretics Pathway, Pharmacodynamics. The drugs Glyburide and Metformin have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and bone, and related phenotypes are Decreased human cytomegalovirus (HCMV) strain AD169 replication and Decreased substrate adherent cell growth

Wikipedia : 72 Polyhydramnios (polyhydramnion, hydramnios, polyhydramnios) is a medical condition describing an excess... more...

Related Diseases for Polyhydramnios

Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 polyhydramnios, megalencephaly, and symptomatic epilepsy 34.0 STK11 STRADA
2 bartter disease 31.6 CLCNKB KCNJ1 SLC12A1
3 bartter syndrome, type 3 31.3 CLCNKB KCNJ1 SLC12A1
4 oligohydramnios 31.0 AFP AQP1 AQP3
5 chorioangioma 29.9 AFP FGFR3
6 antenatal bartter syndrome 29.7 KCNJ1 MAGED2 SLC12A1
7 diabetes insipidus, nephrogenic, autosomal 28.9 AQP1 AQP3 SLC12A1
8 polyhydramnios, chronic idiopathic 11.9
9 muscular hypertrophy-hepatomegaly-polyhydramnios syndrome 11.9
10 esophageal atresia 11.2
11 twin-to-twin transfusion syndrome 11.1
12 bartter syndrome, type 5, antenatal, transient 11.0
13 fetal akinesia syndrome, x-linked 10.9
14 chondrodysplasia, blomstrand type 10.9
15 pontocerebellar hypoplasia, type 4 10.9
16 bartter syndrome, type 2, antenatal 10.9
17 perlman syndrome 10.9
18 restrictive dermopathy, lethal 10.9
19 bartter syndrome, type 1, antenatal 10.9
20 lethal congenital contracture syndrome 7 10.9
21 bartter syndrome type 4 10.9
22 thanatophoric dysplasia, type ii 10.8
23 fetal akinesia deformation sequence 10.8
24 duodenal atresia 10.8
25 multiple pterygium syndrome, lethal type 10.8
26 spinal muscular atrophy, x-linked 2 10.8
27 megalencephaly-capillary malformation-polymicrogyria syndrome 10.8
28 bartter syndrome, type 4a, neonatal, with sensorineural deafness 10.8
29 bartter syndrome, type 4b, neonatal, with sensorineural deafness 10.8
30 nemaline myopathy 10 10.8
31 lethal congenital contracture syndrome 6 10.8
32 congenital chloride diarrhea 10.8
33 tracheal agenesis 10.8
34 renal tubular transport disease 10.0 CLCNKB KCNJ1 SLC12A1
35 neonatal myasthenia gravis 10.0 AFP MUSK
36 dowling-degos disease 1 10.0 FGFR3 STK11
37 dent disease 1 10.0 CLCNKB KCNJ1 SLC12A1
38 gitelman syndrome 10.0 CLCNKB KCNJ1 SLC12A1
39 myotonic dystrophy 10.0
40 hypokalemia 9.9 CLCNKB KCNJ1 SLC12A1
41 nephrocalcinosis 9.9 CLCNKB KCNJ1 SLC12A1
42 hydrops fetalis, nonimmune, and/or atrial septal defect 9.9
43 cervicitis 9.9
44 teratoma 9.9
45 congenital mesoblastic nephroma 9.9
46 hydrops fetalis 9.9
47 uterine anomalies 9.9 AFP STRADA
48 diaphragmatic hernia, congenital 9.8
49 hydronephrosis 9.8
50 cerebritis 9.8

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to Polyhydramnios

Symptoms & Phenotypes for Polyhydramnios

UMLS symptoms related to Polyhydramnios:


morning sickness

GenomeRNAi Phenotypes related to Polyhydramnios according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.26 FGFR3 MUSK STK11 STRADA
2 Decreased substrate adherent cell growth GR00193-A-1 9.02 STK11 STRADA
3 Decreased substrate adherent cell growth GR00193-A-3 9.02 FGFR3 STK11 STRADA

MGI Mouse Phenotypes related to Polyhydramnios:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 MUSK SLC12A1 CNTNAP1 STK11 FGFR3 AFP
2 growth/size/body region MP:0005378 10.02 STK11 KCNJ1 AQP3 MUSK CNTNAP1 SLC12A1
3 homeostasis/metabolism MP:0005376 10.02 AQP3 MUSK CLCNKB SLC12A1 STK11 FGFR3
4 mortality/aging MP:0010768 9.96 AQP3 MUSK CNTNAP1 SLC12A1 STK11 FGFR3
5 renal/urinary system MP:0005367 9.7 CLCNKB SLC12A1 STK11 FGFR3 AQP1 KCNJ1
6 reproductive system MP:0005389 9.5 STK11 CNTNAP1 SLC12A1 FGFR3 AFP HSD17B4
7 vision/eye MP:0005391 9.1 STK11 AQP3 CNTNAP1 FGFR3 HSD17B4 AQP1

Drugs & Therapeutics for Polyhydramnios

Drugs for Polyhydramnios (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 4 10238-21-8 3488
2
Metformin Approved Phase 4 657-24-9 4091 14219
3 Hypoglycemic Agents Phase 4
4
Betamethasone Approved, Vet_approved Phase 1, Phase 2 378-44-9 9782
5 Betamethasone Valerate Phase 1, Phase 2 2152-44-5
6 glucocorticoids Phase 1, Phase 2
7 Respiratory System Agents Phase 1, Phase 2
8 Hormone Antagonists Phase 1, Phase 2
9 Hormones Phase 1, Phase 2
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
11 Anti-Asthmatic Agents Phase 1, Phase 2
12 Anti-Inflammatory Agents Phase 1, Phase 2
13 Betamethasone benzoate Phase 1, Phase 2
14 Betamethasone sodium phosphate Phase 1, Phase 2
15 Betamethasone-17,21-dipropionate Phase 1, Phase 2
16
Zinc Approved, Investigational 7440-66-6 32051 23994
17
Insulin Detemir Approved 169148-63-4 5311023
18
Menthol Approved 2216-51-5 16666
19
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
20
Cholecalciferol Approved, Nutraceutical 67-97-0 10883523 5280795 6221
21
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
22 Micronutrients
23 Trace Elements
24 Vitamins
25 Ergocalciferols
26 Bone Density Conservation Agents
27 Calcium, Dietary
28 insulin
29 Pharmaceutical Solutions
30 Insulin, Globin Zinc
31 Insulin, Isophane
32 Insulin, Long-Acting
33 Insulin, Short-Acting
34 Isophane insulin, beef
35 Isophane Insulin, Human
36 Vitamin D2 Nutraceutical
37 Calciferol Nutraceutical

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
2 Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia Unknown status NCT01240057 Phase 2, Phase 3
3 Syringe or Continuous Amnioreduction for Symptomatic Polyhydramnios. A Prospective Randomized Study. Completed NCT00236340 Phase 3
4 Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM) Terminated NCT00670956 Phase 1, Phase 2 Betamethasone;Placebo
5 Sonographic Assessment of Fetal Deglutition Associated With Hydramnion:Its Absence is Indicative of Central Nervous System (CNS) Pathology Unknown status NCT00687752
6 Vitamin D Treatment and Hypocalcemic Pregnant Women Unknown status NCT02021864 vitamin D3 50,000 unit;prenatal multivitamin
7 Studying Fetal Breathing Patterns Completed NCT00066976
8 Chewing Gums to Stimulate Intestinal Motility After Cesarean Section Completed NCT02386748
9 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy Completed NCT01375439
10 Glycemic Control Using Insulin Levemir Versus Insulin NPH for Diabetes in Pregnancy Completed NCT01837680 Insulin
11 Pregnancy Outcomes and Medical Costs According to Gestational Diabetes Mellitus Diagnostic Criteria Recruiting NCT03421262
12 Real-time Continuous Glucose Monitoring Recruiting NCT03326232
13 One Step Versus Two Step Approach for Gestational Diabetes Mellitus Screening Recruiting NCT03073330
14 Does Amniotic Fluid Index Affect the Fetal Cardiac Performance? Not yet recruiting NCT03277417
15 The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies Not yet recruiting NCT02732717

Search NIH Clinical Center for Polyhydramnios

Cochrane evidence based reviews: polyhydramnios

Genetic Tests for Polyhydramnios

Genetic tests related to Polyhydramnios:

# Genetic test Affiliating Genes
1 Polyhydramnios 28

Anatomical Context for Polyhydramnios

MalaCards organs/tissues related to Polyhydramnios:

38
Placenta, Lung, Bone, Kidney, Brain, Heart, Fetal Lung

Publications for Polyhydramnios

Articles related to Polyhydramnios:

(show top 50) (show all 336)
# Title Authors Year
1
Targeted gene panel sequencing prenatally detects two novel mutations of DYNC2H1 in a fetus with increased biparietal diameter and polyhydramnios. ( 29359448 )
2018
2
Delivery outcomes of term pregnancy complicated by idiopathic polyhydramnios. ( 28643663 )
2017
3
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? ( 29076544 )
2017
4
Polyhydramnios or Excessive Fetal Growth Are Markers for Abnormal Perinatal Outcome in Euglycemic Pregnancies. ( 28838004 )
2017
5
Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation. ( 28620499 )
2017
6
Isolated polyhydramnios in the third trimester: is a gestational diabetes evaluation of value?() ( 28488900 )
2017
7
Pregnant woman with polyhydramnios and fetus with small intestinal atresia. ( 28925193 )
2017
8
Polyhydramnios Affecting a Recipient-like Twin: Risk of Progression to Twin-Twin Transfusion Syndrome and Outcomes. ( 29287298 )
2017
9
Prenatal drainage of fetal urinoma with polyhydramnios: a case report and literature review. ( 28076981 )
2017
10
Polyhydramnios - frequency of congenital anomalies in relation to the value of the amniotic fluid index. ( 28930371 )
2017
11
Outcome of pregnancy in women diagnosed with idiopathic polyhydramnios. ( 28251633 )
2017
12
Amount of polyhydramnios attributable to diabetes may be less than previously reported. ( 28138359 )
2017
13
Perinatal outcome in pregnancy with polyhydramnios in comparison with normal pregnancy in department of obstetrics at Shiraz University of Medical Sciences. ( 28462606 )
2017
14
Foetal biometry in polyhydramnios: Does femur length fall behind? ( 26467094 )
2016
15
Idiopathic polyhydramnios at term and pregnancy outcomes: a multicenter observational study. ( 27625160 )
2016
16
Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations. ( 27120771 )
2016
17
Outcomes From Polyhydramnios With Normal Ultrasound. ( 26755694 )
2016
18
Fetal hypothyroidism induced by maternal anti-TSH receptor blocking antibodies and complicated by polyhydramnios despite the absence of goiter. Treatment by intra-amniotic injections of levothyroxine. ( 27919402 )
2016
19
Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. ( 26847765 )
2016
20
Pregnancy outcomes in severe polyhydramnios: no increase in risk in patients needing amnioreduction for maternal pain or respiratory distress. ( 26948899 )
2016
21
EP21.17: Amnioreduction procedure for singleton pregnancies complicated by polyhydramnios causing maternal discomfort. ( 27647433 )
2016
22
A Case of the TOF with APV Complicated with Polyhydramnios and Severe Bronchomalacia. ( 27579200 )
2016
23
QUESTION 1: Should the passage of a nasogastric tube be universal to all babies born to mothers with polyhydramnios or targeted to those with additional findings on ultrasound? ( 27540183 )
2016
24
Polyhydramnios and cerebellar atrophy: a prenatal presentation of mitochondrial encephalomyopathy caused by mutations in the FBXL4 gene. ( 27099744 )
2016
25
Pregnancy after oocyte donation in 45, X Turner syndrome women, complicated by gestational diabetes and polyhydramnios. Case report and mini-review of literature. ( 26942946 )
2016
26
Idiopathic Polyhydramnios: Severity and Perinatal Morbidity. ( 26862725 )
2016
27
Transient antenatal Bartter's Syndrome and X-linked polyhydramnios: insights from theA genetics of a rare condition. ( 27633862 )
2016
28
Hyperechogenic kidneys and polyhydramnios associated with HNF1B gene mutation. ( 27286685 )
2016
29
Prenatal ultrasound factors and genetic disorders in pregnancies complicated by polyhydramnios. ( 27247190 )
2016
30
Idiopathic polyhydramnios: persistence across gestation and impact on pregnancy outcomes. ( 26937648 )
2016
31
Mode of delivery among women admitted with polyhydramnios. ( 28019126 )
2016
32
Prenatal Diagnosis and Pregnancy Outcome Analysis of Polyhydramnios. ( 26720631 )
2016
33
Variable genetic penetrance of myotonic dystrophy following the diagnosis of idiopathic polyhydramnios. ( 27039051 )
2016
34
Intrapartum, postpartum characteristics and early neonatal outcomes of idiopathic polyhydramnios. ( 26926000 )
2016
35
Can the Myocardial Performance Index Be Used as a New Predictive Factor for a Poor Prognosis in Fetuses With Idiopathic Polyhydramnios? ( 27821651 )
2016
36
Molecular cytogenetic characterization of inv dup del(8p) in a fetus associated with ventriculomegaly, hypoplastic left heart, polyhydramnios and intestinal obstruction. ( 27343326 )
2016
37
Prevalence of a positive TORCH and parvovirus B19 screening in pregnancies complicated by polyhydramnios. ( 26970557 )
2016
38
Polyhydramnios in isolated oral cleft pregnancies: incidence and outcome in a retrospective study. ( 27943390 )
2016
39
Rapid Resolution of Polyhydramnios Foretells Circulatory Collapse for the Donor Twin in Feto-Fetal Transfusion Syndrome. ( 26932285 )
2016
40
Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE). ( 27170158 )
2016
41
Reply to "Questions about and speculations on the incidence of idiopathic polyhydramnios by fetal gender". ( 25786638 )
2015
42
Association of isolated polyhydramnios at or beyond 34 weeks of gestation and pregnancy outcome. ( 25751210 )
2015
43
Acute polyhydramnios after maternal status epilepticus. ( 26331018 )
2015
44
Polyhydramnios associated with Prader-Willi syndrome. ( 26291428 )
2015
45
Questions about and speculations on the incidence of idiopathic polyhydramnios by fetal gender. ( 25786637 )
2015
46
Perinatal Outcome in Idiopathic Polyhydramnios. ( 26405400 )
2015
47
Polyhydramnios associated with Prader-Willi syndrome. ( 26271012 )
2015
48
Decreased umbilical orexin-A level is associated with idiopathic polyhydramnios. ( 25494826 )
2015
49
Amniotic fluid biochemistry in isolated polyhydramnios: a series of 464 cases. ( 26426702 )
2015
50
Idiopathic polyhydramnios and fetal gender. ( 25288271 )
2014

Variations for Polyhydramnios

Expression for Polyhydramnios

Search GEO for disease gene expression data for Polyhydramnios.

Pathways for Polyhydramnios

Pathways related to Polyhydramnios according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.58 STK11 STRADA
2 10.26 CLCNKB KCNJ1 SLC12A1

GO Terms for Polyhydramnios

Biological processes related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein autophosphorylation GO:0046777 9.5 FGFR3 MUSK STK11
2 potassium ion transport GO:0006813 9.43 AQP1 KCNJ1 SLC12A1
3 odontogenesis GO:0042476 9.4 AQP1 AQP3
4 renal water homeostasis GO:0003091 9.37 AQP1 AQP3
5 water transport GO:0006833 9.16 AQP1 AQP3
6 glycerol transport GO:0015793 8.96 AQP1 AQP3
7 excretion GO:0007588 8.8 AQP3 CLCNKB KCNJ1

Molecular functions related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.56 FGFR3 MUSK STK11 STRADA
2 channel activity GO:0015267 9.16 AQP1 AQP3
3 protein kinase activator activity GO:0030295 8.96 STK11 STRADA
4 water channel activity GO:0015250 8.62 AQP1 AQP3

Sources for Polyhydramnios

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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