MCID: PLY012
MIFTS: 49

Polyhydramnios malady

Summaries for Polyhydramnios

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Polyhydramnios (polyhydramnion, hydramnios, polyhydramnios) is a medical condition describing an excess... more...

MalaCards: Polyhydramnios is related to diabetes insipidus and nephrogenic diabetes insipidus. An important gene associated with Polyhydramnios is STRADA (STE20-related kinase adaptor alpha), and among its related pathways are IRS-related events and Diuretics Pathway, Pharmacodynamics. The compounds gemeprost and pcmbs have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and small intestine, and related mouse phenotypes are digestive/alimentary and renal/urinary system.

Disease Ontology:8 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

Aliases & Classifications for Polyhydramnios

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 25ICD10
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Related Diseases for Polyhydramnios

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus29.7OXT
2nephrogenic diabetes insipidus29.7OXT, AQP1
3bartter disease29.7KCNJ1, BSND, CLCNKB
4twin twin transfusion syndrome10.3
5chorioangioma10.3
6mesoblastic nephroma10.2
7teratoma10.1
8hydronephrosis10.1
9costello syndrome10.1
10congenital diaphragmatic hernia10.1
11n syndrome10.1
12congenital myotonic dystrophy10.1
13hydrops fetalis10.1
14nephrolithiasis10.0CLCNKB
15testicular germ cell tumor10.0STK11, FGFR3
16hydrarthrosis10.0AQP9
17edwards syndrome10.0AFP
18oligohydramnios10.0AFP, OXT, AQP8
19cystic lymphangioma10.0AFP
20hydrocephalus10.0AQP1, AFP
21bartter syndrome type 310.0CLCNKB, KCNJ1
22gitelman syndrome10.0CLCNKB, BSND, KCNJ1
23hypokalemia10.0KCNJ1, BSND, CLCNKB
24pseudohypoaldosteronism10.0
25hypercalcemia10.0
26achondrogenesis type ib10.0
27adenoma10.0
28micro syndrome10.0
29chondrodysplasia blomstrand type10.0
30diffuse neonatal hemangiomatosis10.0
31duodenal atresia10.0
32tight skin contracture syndrome, lethal10.0
33multiple pterygium syndrome lethal type10.0
34miller-dieker syndrome10.0
35renal hamartomas nephroblastomatosis and fetal gigantism10.0
36thanatophoric dysplasia type 110.0
37polyhydramnios, megalencephaly, and symptomatic epilepsy10.0
38omphalocele10.0
39muscular hypertrophy - hepatomegaly - polyhydramnios10.0
40cystic fibrosis10.0KCNJ1, SLC26A3, AQP1, AQP3
41vacterl association9.8
42smith-lemli-opitz syndrome9.8
43multiple intestinal atresia9.8
44treacher collins syndrome9.8
45rubinstein-taybi syndrome9.8
46hyperuricemia9.8
47congenital epulis9.8
48fg syndrome9.8
49junctional epidermolysis bullosa9.8
50twin-to-twin transfusion syndrome9.8

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to polyhydramnios

Clinical Features for Polyhydramnios

Drugs & Therapeutics for Polyhydramnios

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Polyhydramnios

Drug clinical trials:

Search ClinicalTrials for Polyhydramnios

Search NIH Clinical Center for Polyhydramnios

Search CenterWatch for Polyhydramnios

Genetic Tests for Polyhydramnios

Anatomical Context for Polyhydramnios

Sources:
33MalaCards
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MalaCards organs/tissues related to Polyhydramnios:

33
Brain, Heart, Small intestine, Kidney, Liver, Lung, Placenta, Fetal brain, Fetal liver, Fetal lung

Animal Models for Polyhydramnios or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Polyhydramnios

Sources:
51PubMed
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Articles related to Polyhydramnios:

(show top 50)    (show all 276)
idTitleAuthorsYear
1
Polyhydramnios as a predictor of adverse pregnancy outcomes. (23573383)
2013
2
Twin-twin transfusion syndrome presenting as polyhydramnios in both fetuses secondary to spontaneous microseptostomy. (24147241)
2013
3
Chinese herbal medicine in treatment of polyhydramnios:a meta-analysis and systematic review. (23806368)
2013
4
TORCH screening in polyhydramnios: an observational study. (21923307)
2012
5
The amnioscope strikes back as a useful device for pinhole amniotomy in the management of polyhydramnios. (23705096)
2011
6
Prenatal MRI of an esophageal duplication cyst with polyhydramnios and right pleural effusion. (22191299)
2011
7
Clinical application of fetal urine production rate in unexplained polyhydramnios. (19830790)
2009
8
Prenatal diagnosis of partial trisomy 14q (14q31.1-->qter) and partial monosomy 5p (5p13.2-->pter) associated with polyhydramnios, short limbs, micropenis and brain malformations. (19852436)
2009
9
The effect of polyhydramnios on cervical length in twins: a controlled intervention study in complicated monochorionic pregnancies. (19048106)
2008
10
Acute recurrent polyhydramnios: a combination of amniocenteses and NSAID may be curative rather than palliative. (17228156)
2007
11
Twin anemia-polycythemia sequence in two monochorionic twin pairs without oligo-polyhydramnios sequence. (16516289)
2007
12
A rare cause of polyhydramnios: Neu-Laxova syndrome. (16923700)
2006
13
Benign multiple diffuse neonatal hemangiomatosis after a pregnancy complicated by polyhydramnios and a placental chorioangioma. (12475589)
2003
14
Use of continuous fluid drainage for severe polyhydramnios due to twin to twin transfusion syndrome. (11491373)
2001
15
Isolated craniosynostosis: prenatal ultrasound of scaphocephaly with polyhydramnios. (11858399)
2001
16
Severe polyhydramnios in twin reversed arterial perfusion sequence: successful management with intrafetal alcohol ablation of acardiac twin and amniodrainage. (11169293)
2000
17
Congenital pseudohypoaldosteronism presenting in utero with acute polyhydramnios. (9584819)
1998
18
Prevalence of polyhydramnios in the third trimester in a population screened by first and second trimester ultrasonography. (10027132)
1998
19
Amniotic septostomy for the treatment of twin oligohydramnios-polyhydramnios sequence. (9650653)
1998
20
Intermembraneous polyhydramnios in a pregnancy with separated membranes. (9351420)
1997
21
Polyhydramnios. (9199839)
1997
22
Polyhydramnios is an independent risk factor for perinatal mortality and intrapartum morbidity in preterm delivery. (9031919)
1996
23
The underlying cause of polyhydramnios determines prematurity. (8821853)
1996
24
Fetal renal artery flow velocity waveforms in normal pregnancies and pregnancies complicated by polyhydramnios and oligohydramnios. (8459967)
1993
25
Myasthenia gravis with polyhydramnios in the fetus of an asymptomatic mother. (8372081)
1993
26
Twin-to-twin transfusion syndrome: a subset of the twin oligohydramnios-polyhydramnios sequence. (8238150)
1993
27
Indomethacin use to control gross polyhydramnios complicating triplet pregnancy. (8476837)
1993
28
Efficacy and safety of indomethacin therapy for polyhydramnios. (8163032)
1993
29
Congenital myotonic dystrophy: an often unsuspected cause of severe polyhydramnios. (2062816)
1991
30
Acute polyhydramnios in twin pregnancy. A retrospective study with special reference to therapeutic amniocentesis. (2244460)
1990
31
Acute and subacute polyhydramnios in singleton pregnancies. (2256854)
1990
32
Polyhydramnios and associated maternal and fetal complications in singleton pregnancies. (2279018)
1990
33
Quantifiable polyhydramnios: diagnosis and management. (2188185)
1990
34
Postpartum polyhydramnios: a unique complication of advanced abdominal pregnancy. (3306507)
1987
35
Placental chorioangioma, an unusual cause of polyhydramnios: antenatal diagnosis. (2939090)
1986
36
Increased acinar complexity with polyhydramnios. (2945174)
1986
37
Polyhydramnios caused by giant alveolar granular cell myoblastoma. (3022540)
1986
38
Analysis of amniotic fluid proteins by isoelectrofocusing (IEF) in pregnancies complicated by polyhydramnios and Rh-sensitization. (3089337)
1986
39
Acute polyhydramnios complicating monozygous twin pregnancies--case report. (3546664)
1986
40
Congenital granular cell epulis causing polyhydramnios. (3916694)
1985
41
Acute polyhydramnios complicating twin pregnancies. (3914165)
1985
42
Mid-trimester acute polyhydramnios and fetal sacro-coccygeal teratoma. (6375647)
1984
43
Polyhydramnios: threat of a handicapped child. (6193831)
1983
44
Fetal cervical teratoma as a cause of polyhydramnios. (382080)
1979
45
Polyhydramnios, congenital malformations, and intrauterine detection. (323813)
1977
46
Primary pulmonary hypoplasia: report of a case with polyhydramnios. (335880)
1977
47
Antepartum thrombophlebitis complicated by hyperuricemia, uremia, and polyhydramnios. (4896448)
1969
48
Heterotopic pregnancy. Report of a case complicated by polyhydramnios and partial small bowel obstruction. (5319148)
1965
49
Polyhydramnios; report of a case. (13463908)
1957
50
Multipara with a polyhydramnios associated with a fetus whose cranium was grossly deformed]. (20296495)
1947

Genetic Variations for Polyhydramnios

Expression for genes affiliated with Polyhydramnios

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyhydramnios

Search GEO for disease gene expression data for Polyhydramnios.

Pathways for genes affiliated with Polyhydramnios

Sources:
54Reactome, 50PharmGKB, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Polyhydramnios

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
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Compounds related to Polyhydramnios according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1gemeprost4510.3OXT, AFP
2pcmbs4510.3AQP1, AQP3
3hgcl24510.3AQP3, AQP1
4mercury4510.1AQP1, AQP3, AQP9
5dids45 2911.1CLCNKB, AQP1
6silver4510.0AFP, AQP1, AQP3
7hg2+299.9AQP9, AQP8, AQP3, AQP1
8urea45 11 2411.9AFP, AQP1, AQP3, AQP9
9chlorine45 2410.9SLC26A3, CLCNKB, BSND
10mannitol45 1110.9AQP9, AQP3, AQP1, OXT
11paraffin459.8AQP1, FGFR3, OXT, AFP, STK11
12glycerol45 11 2411.8AQP1, AQP3, AQP8, AQP9
13potassium45 11 2411.7KCNJ1, BSND, AFP, CLCNKB, RAPSN, AQP1
14sodium45 2410.7KCNJ1, BSND, AFP, CLCNKB, RAPSN, AQP1
15nacl459.7KCNJ1, BSND, AFP, CLCNKB, SLC26A3, AQP1
16chloride459.7KCNJ1, BSND, CLCNKB, SLC26A3, AQP1, AQP3
17vegf459.6AFP, OXT, FGFR3, AQP1, STK11
18forskolin45 50 1111.4AQP8, AQP3, AQP1, OXT
19calcium45 50 11 2412.0CAMLG, BSND, STK11, AFP, OXT, FGFR3

GO Terms for genes affiliated with Polyhydramnios

Sources:
16Gene Ontology
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Cellular components related to Polyhydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.5AQP9, AQP3, AQP1, BSND
2integral to plasma membraneGO:0058879.3FGFR3, CLCNKB, AQP1, AQP8, AQP9, BSND
3plasma membraneGO:0058868.2KCNJ1, BSND, FGFR3, CLCNKB, RAPSN, SLC26A3

Biological processes related to Polyhydramnios according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1glycerol transportGO:01579310.0AQP9, AQP1
2insulin receptor signaling pathwayGO:00828610.0FGFR3, STRADA, STK11
3tissue homeostasisGO:00189410.0STK11, KCNJ1
4canalicular bile acid transportGO:01572210.0AQP8, AQP9
5activation of protein kinase activityGO:0321479.9STK11, STRADA
6water transportGO:0068339.8AQP1, AQP3, AQP8, AQP9
7cellular response to cAMPGO:0713209.7AQP9, AQP8, AQP1, SLC26A3
8excretionGO:0075889.6AQP9, AQP3, SLC26A3, CLCNKB, KCNJ1
9transportGO:0068109.6AQP9, AQP8, AQP3, CLCNKB, AFP
10transmembrane transportGO:0550859.2BSND, CLCNKB, SLC26A3, AQP1, AQP3, AQP8

Molecular functions related to Polyhydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase activator activityGO:03029510.2STRADA, STK11
2water transmembrane transporter activityGO:0053729.7AQP9, AQP1
3water channel activityGO:0152509.5AQP9, AQP8, AQP3, AQP1

Products for genes affiliated with Polyhydramnios

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polyhydramnios

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet