MCID: PLY012
MIFTS: 49

Polyhydramnios malady

Summaries for Polyhydramnios

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Polyhydramnios (polyhydramnion, hydramnios, polyhydramnios) is a medical condition describing an excess... more...

MalaCards: Polyhydramnios is related to oligohydramnios and diabetes insipidus. An important gene associated with Polyhydramnios is STRADA (STE20-related kinase adaptor alpha), and among its related pathways are IRS-related events and Diuretics Pathway, Pharmacodynamics. The compounds gemeprost and pcmbs have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and lung, and related mouse phenotypes are digestive/alimentary and renal/urinary system.

Disease Ontology:8 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

Aliases & Classifications for Polyhydramnios

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Polyhydramnios

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17GeneCards, 18GeneDecks
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Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1oligohydramnios30.7AQP8, OXT, AFP
2diabetes insipidus29.7OXT
3nephrogenic diabetes insipidus29.7AQP1, OXT
4bartter disease29.7BSND, KCNJ1, CLCNKB
5chorioangioma10.3
6twin-to-twin transfusion syndrome10.1
7cervicitis10.1
8congenital mesoblastic nephroma10.1
9myotonic dystrophy10.1
10hydronephrosis10.0
11cerebritis10.0
12costello syndrome10.0
13congenital diaphragmatic hernia10.0
14ovarian cyst10.0
15nephrolithiasis10.0CLCNKB
16testicular germ cell tumor10.0FGFR3, STK11
17hydrarthrosis10.0AQP9
18edwards syndrome10.0AFP
19cystic lymphangioma10.0AFP
20hydrocephalus10.0AQP1, AFP
21bartter syndrome type 310.0CLCNKB, KCNJ1
22gitelman syndrome10.0CLCNKB, BSND, KCNJ1
23hypokalemia10.0CLCNKB, KCNJ1, BSND
24cystic fibrosis10.0SLC26A3, AQP3, AQP1, KCNJ1
25pseudohypoaldosteronism10.0
26hypercalcemia10.0
27achondrogenesis type ib10.0
28esophagitis10.0
29laryngitis10.0
30chondrodysplasia blomstrand type10.0
31duodenal atresia10.0
32tight skin contracture syndrome, lethal10.0
33multiple pterygium syndrome lethal type10.0
34renal hamartomas nephroblastomatosis and fetal gigantism10.0
35thanatophoric dysplasia type 110.0
36polyhydramnios, megalencephaly, and symptomatic epilepsy10.0
37muscular hypertrophy - hepatomegaly - polyhydramnios10.0
38vacterl association9.8
39smith-lemli-opitz syndrome9.8
40multiple intestinal atresia9.8
41treacher collins syndrome9.8
42rubinstein-taybi syndrome9.8
43hyperuricemia9.8
44congenital epulis9.8
45junctional epidermolysis bullosa9.8
46achondroplasia9.8
47digeorge syndrome9.8
48lissencephaly9.8
49boomerang dysplasia9.8
50distal arthrogryposis9.8

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to polyhydramnios

Clinical Features for Polyhydramnios

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Drugs & Therapeutics for Polyhydramnios

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Polyhydramnios

Drug clinical trials:

Search ClinicalTrials for Polyhydramnios

Search NIH Clinical Center for Polyhydramnios

Search CenterWatch for Polyhydramnios

Genetic Tests for Polyhydramnios

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Anatomical Context for Polyhydramnios

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32MalaCards
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MalaCards organs/tissues related to Polyhydramnios:

32
Placenta, Brain, Lung, Heart, Bone, Kidney, Liver, Fetal lung

Animal Models for Polyhydramnios or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polyhydramnios:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.3AQP8, OXT, FGFR3, SLC26A3, AQP3, STK11
2MP:00053679.0KCNJ1, BSND, STK11, OXT, FGFR3, AQP3
3MP:00053868.6STK11, AQP1, KCNJ1, AQP3, TEF, FGFR3
4MP:00053978.5STK11, BSND, FARSA, FGFR3, CAMLG, AQP1
5MP:00053768.0SLC26A3, AQP8, AQP3, AQP1, TEF, FGFR3
6MP:00107687.9STK11, KCNJ1, CAMLG, FARSA, BSND, AFP

Publications for Polyhydramnios

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50PubMed
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Articles related to Polyhydramnios:

(show top 50)    (show all 276)
idTitleAuthorsYear
1
Fetal swallowing as a protective mechanism against oligohydramnios and polyhydramnios in late gestation sheep. (22872543)
2013
2
Clinical relevance of sonographically estimated amniotic fluid volume: polyhydramnios. (23620328)
2013
3
Polyhydramnios, an unusual complication in pregnancy with hyperreactio luteinalis: a case report. (23936992)
2013
4
Congenital laryngeal cyst: a rare cause of polyhydramnios. (24040590)
2013
5
Maximal amniotic fluid index as a prognostic factor in pregnancies complicated by polyhydramnios. (21898637)
2012
6
Idiopathic polyhydramnios and postnatal abnormalities. (22760013)
2012
7
Congenital omphalocele and polyhydramnios: a study of 52 cases. (21709401)
2011
8
Placental chorioangioma - an unusual cause of acute polyhydramnios with an isolated rise in maternal serum ALT: a clinical marker of disease and/or risk? (21973147)
2011
9
Case of polyhydramnios complicated by Opitz G/BBB syndrome. (20666962)
2010
10
Idiopathic polyhydramnios and postnatal findings. (19085623)
2009
11
Polyhydramnios and abdominal distention in a newborn. (18847625)
2008
12
Monochorionic twin fetuses showing a reversal of donor-recipient phenotypes in severe twin-twin transfusion syndrome without oligo-polyhydramnios sequence. (18452491)
2008
13
Fetal manifestation of the Fine-Lubinsky syndrome. Brachycephaly, deafness, cataract, microstomia and mental retardation syndrome complicated by Pierre-Robin anomaly and polyhydramnios. (18417983)
2008
14
Acute polyhydramnios causing bilateral obstructive hydronephrosis and impaired renal function. (17999311)
2007
15
Steady-state levels of aquaporin 1 mRNA expression are increased in idiopathic polyhydramnios. (16522429)
2006
16
Clinical features of polyhydramnios associated with fetal anomalies. (17096817)
2006
17
Perinatal outcomes of polyhydramnios without associated congenital fetal anomalies after the gestational age of 20 weeks. (16013341)
2005
18
Amnioreduction for treatment of severe polyhydramnios. (15301292)
2004
19
Influence of vasopressin in the pathogenesis of oligohydramnios-polyhydramnios in monochorionic twins. (15036711)
2004
20
Polyhydramnios and arterio-arterial placental anastomoses may beneficially affect monochorionic twin pregnancies. (11277233)
2001
21
Idiopathic polyhydramnios and perinatal outcome. (10561621)
1999
22
Severity of polyhydramnios does not affect the prevalence of large-for-gestational-age newborn infants. (8731446)
1996
23
In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale. (8843476)
1996
24
Is polyhydramnios in an ultrasonographically normal fetus an indication for genetic evaluation? (7503195)
1995
25
Polyhydramnios and hypercalcemia associated with congenital mesoblastic nephroma: case report and a new appraisal. (7724122)
1995
26
Significance of idiopathic midtrimester polyhydramnios. (7945628)
1994
27
Persistence of polyhydramnios during pregnancy--its significance and correlation with maternal and fetal complications. (8125402)
1994
28
Umbilical cord hemangioma associated with polyhydramnios, congenital abnormalities and perinatal death in a twin pregnancy. (8090598)
1994
29
Treatment of polyhydramnios with indomethacin. (7982337)
1994
30
Duchenne muscular dystrophy associated with fetal pleural effusion and polyhydramnios. (8177833)
1993
31
Maternal smoking and the risk of polyhydramnios. (1739142)
1992
32
Prenatal diagnosis of a large liver cavernous haemangioma associated with polyhydramnios. (1557314)
1992
33
Indomethacin treatment for polyhydramnios. Effective but potentially dangerous? (1317651)
1992
34
Pathophysiology of polyhydramnios in twin transfusion syndrome. (1386987)
1992
35
Hydrops fetalis, polyhydramnios, pulmonary hypoplasia, and Down syndrome. (1532311)
1992
36
Diagnosis of polyhydramnios in early gestation: indication for prenatal diagnosis? (1837357)
1991
37
The significance of polyhydramnios diagnosed during labour or at caesarean section. (2256856)
1990
38
Polyhydramnios with maternal lithium treatment. (2406668)
1990
39
Treacher-Collins syndrome: an association with polyhydramnios. (3141842)
1988
40
Polyhydramnios associated with a ring chromosome and low maternal serum alpha-fetoprotein levels managed with indomethacin. (2453113)
1988
41
Reversal of acute polyhydramnios after fetal renal decompression. (3276074)
1988
42
Acute polyhydramnios recurrent in four pregnancies. A case report. (3550067)
1987
43
Serial amniocenteses in the treatment of twin to twin transfusion complicated with acute polyhydramnios. (3529788)
1986
44
Prenatal appearance of a mesoblastic nephroma associated with polyhydramnios. (2997303)
1985
45
Third trimester ultrasound diagnosis of intestinal atresia following clinical evidence of polyhydramnios. (3895218)
1985
46
Acute polyhydramnios associated with fetal hepatoblastoma. (2993051)
1985
47
Polyhydramnios and obstructive renal failure: a case report and review of the literature. (3895955)
1985
48
Chronic idiopathic polyhydramnios: evidence for a defect in the chorion laeve receptor for lactogenic hormones. (6296188)
1983
49
Polyhydramnios: the value of diagnostic amniocentesis in third trimester pregnancies. (395439)
1979
50
Polyhydramnios and neonatal hemorrhage in three sisters. A circumvallate placenta syndrome? (4608262)
1974

Genetic Variations for Polyhydramnios

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Expression for genes affiliated with Polyhydramnios

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyhydramnios

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Pathways for genes affiliated with Polyhydramnios

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53Reactome, 49PharmGKB, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Polyhydramnios

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Polyhydramnios according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1gemeprost4410.3OXT, AFP
2pcmbs4410.3AQP1, AQP3
3hgcl24410.3AQP3, AQP1
4mercury4410.1AQP1, AQP3, AQP9
5dids44 2811.1CLCNKB, AQP1
6silver4410.0AFP, AQP1, AQP3
7hg2+289.9AQP9, AQP8, AQP3, AQP1
8urea44 11 2411.9AFP, AQP1, AQP3, AQP9
9chlorine44 2410.9SLC26A3, CLCNKB, BSND
10mannitol44 1110.9AQP9, AQP3, AQP1, OXT
11paraffin449.8AQP1, FGFR3, OXT, AFP, STK11
12glycerol44 11 2411.8AQP1, AQP3, AQP8, AQP9
13potassium44 11 2411.7KCNJ1, BSND, AFP, CLCNKB, RAPSN, AQP1
14sodium44 2410.7KCNJ1, BSND, AFP, CLCNKB, RAPSN, AQP1
15nacl449.7KCNJ1, BSND, AFP, CLCNKB, SLC26A3, AQP1
16chloride449.7KCNJ1, BSND, CLCNKB, SLC26A3, AQP1, AQP3
17vegf449.6AFP, OXT, FGFR3, AQP1, STK11
18forskolin44 49 1111.4AQP8, AQP3, AQP1, OXT
19calcium44 49 11 2412.0CAMLG, BSND, STK11, AFP, OXT, FGFR3

GO Terms for genes affiliated with Polyhydramnios

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16Gene Ontology
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Cellular components related to Polyhydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.5AQP9, AQP3, AQP1, BSND
2integral to plasma membraneGO:0058879.3FGFR3, CLCNKB, AQP1, AQP8, AQP9, BSND
3plasma membraneGO:0058868.2KCNJ1, BSND, FGFR3, CLCNKB, RAPSN, SLC26A3

Biological processes related to Polyhydramnios according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1glycerol transportGO:01579310.0AQP9, AQP1
2insulin receptor signaling pathwayGO:00828610.0FGFR3, STRADA, STK11
3tissue homeostasisGO:00189410.0STK11, KCNJ1
4canalicular bile acid transportGO:01572210.0AQP8, AQP9
5activation of protein kinase activityGO:0321479.9STK11, STRADA
6water transportGO:0068339.8AQP1, AQP3, AQP8, AQP9
7cellular response to cAMPGO:0713209.7AQP9, AQP8, AQP1, SLC26A3
8excretionGO:0075889.6AQP9, AQP3, SLC26A3, CLCNKB, KCNJ1
9transportGO:0068109.6AQP9, AQP8, AQP3, CLCNKB, AFP
10transmembrane transportGO:0550859.2BSND, CLCNKB, SLC26A3, AQP1, AQP3, AQP8

Molecular functions related to Polyhydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase activator activityGO:03029510.2STRADA, STK11
2water transmembrane transporter activityGO:0053729.7AQP9, AQP1
3water channel activityGO:0152509.5AQP9, AQP8, AQP3, AQP1

Products for genes affiliated with Polyhydramnios

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  • Antibodies
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Sources for Polyhydramnios

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet