Aliases & Classifications for Polyhydramnios

MalaCards integrated aliases for Polyhydramnios:

Name: Polyhydramnios 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8488
ICD10 33 O40
ICD9CM 35 657 657.0
MeSH 42 D006831
NCIt 47 C92848
UMLS 69 C0020224

Summaries for Polyhydramnios

Disease Ontology : 12 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

MalaCards based summary : Polyhydramnios is related to bartter syndrome, type 3 and polyhydramnios, megalencephaly, and symptomatic epilepsy, and has symptoms including morning sickness An important gene associated with Polyhydramnios is STRADA (STE20-Related Kinase Adaptor Alpha), and among its related pathways/superpathways are LKB1 signaling events and Diuretics Pathway, Pharmacodynamics. The drugs Glyburide and Metformin have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and bone, and related phenotypes are Decreased substrate adherent cell growth and behavior/neurological

Wikipedia : 72 Polyhydramnios (polyhydramnion, hydramnios, polyhydramnios) is a medical condition describing an excess... more...

Related Diseases for Polyhydramnios

Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
id Related Disease Score Top Affiliating Genes
1 bartter syndrome, type 3 31.2 CLCNKB KCNJ1 SLC12A1
2 polyhydramnios, megalencephaly, and symptomatic epilepsy 12.2
3 muscular hypertrophy-hepatomegaly-polyhydramnios syndrome 11.8
4 esophageal atresia 11.1
5 oligohydramnios 11.1
6 twin-to-twin transfusion syndrome 11.0
7 bartter syndrome, type 5, antenatal, transient 10.9
8 fetal akinesia syndrome x-linked 10.8
9 restrictive dermopathy, lethal 10.8
10 perlman syndrome 10.8
11 chondrodysplasia, blomstrand type 10.8
12 bartter syndrome, type 2 10.8
13 bartter syndrome, type 1 10.8
14 lethal congenital contracture syndrome 7 10.8
15 pontocerebellar hypoplasia type 4 10.8
16 bartter syndrome type 4 10.8
17 bartter syndrome, type 4b, digenic 10.6
18 bartter syndrome, type 4a 10.6
19 multiple pterygium syndrome, lethal type 10.6
20 nemaline myopathy 10 10.6
21 megalencephaly-capillary malformation-polymicrogyria syndrome, somatic 10.6
22 thanatophoric dysplasia, type ii 10.6
23 fetal akinesia deformation sequence 10.6
24 lethal congenital contracture syndrome 6 10.6
25 spinal muscular atrophy, x-linked 2, infantile 10.6
26 duodenal atresia 10.6
27 bartter disease 10.6
28 tracheal agenesis 10.6
29 long qt syndrome 13 10.4 KCNJ1 SLC12A1
30 oligodontia-colorectal cancer syndrome 10.4 STK11 STRADA
31 pulmonary artery hypoplasia 10.3 KCNJ1 MAGED2 SLC12A1
32 oculoauricular syndrome 10.1 RAPSN TUBB2B
33 rhinitis 10.1 CLCNKB KCNJ1 SLC12A1
34 bestrophinopathy 10.1 CLCNKB KCNJ1 SLC12A1
35 spondyloepimetaphyseal dysplasia, faden-alkuraya type 10.0 CLCNKB KCNJ1 SLC12A1
36 pediatric angiosarcoma 10.0 CLCNKB KCNJ1 SLC12A1
37 chorioangioma 10.0
38 epidermolysis bullosa simplex-mcr 10.0 FGFR3 STK11
39 mixed receptive-expressive language disorder 10.0 CLCNKB KCNJ1 SLC12A1
40 myotonic dystrophy 9.9
41 vagina leiomyosarcoma 9.8 AQP1 AQP3
42 rectosigmoid junction neoplasm 9.8 AFP FGFR3
43 cervicitis 9.8
44 teratoma 9.8
45 congenital mesoblastic nephroma 9.8
46 hydronephrosis 9.8
47 cerebritis 9.8
48 congenital diaphragmatic hernia 9.8
49 ovarian cyst 9.8
50 hydrops fetalis 9.8

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to Polyhydramnios

Symptoms & Phenotypes for Polyhydramnios

UMLS symptoms related to Polyhydramnios:


morning sickness

GenomeRNAi Phenotypes related to Polyhydramnios according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.02 STK11 STRADA
2 Decreased substrate adherent cell growth GR00193-A-3 9.02 FGFR3 STK11 STRADA

MGI Mouse Phenotypes related to Polyhydramnios:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 AFP AQP1 AQP3 CNTNAP1 FGFR3 HSD17B4
2 homeostasis/metabolism MP:0005376 10.07 AFP AQP1 AQP3 CLCNKB FGFR3 HSD17B4
3 growth/size/body region MP:0005378 10.06 STK11 TUBB2B AQP1 AQP3 CNTNAP1 FGFR3
4 mortality/aging MP:0010768 10.06 CNTNAP1 FGFR3 HSD17B4 KCNJ1 RAPSN SLC12A1
5 renal/urinary system MP:0005367 9.8 AQP1 AQP3 CLCNKB FGFR3 KCNJ1 SLC12A1
6 reproductive system MP:0005389 9.76 AFP AQP1 CNTNAP1 FGFR3 HSD17B4 SLC12A1
7 respiratory system MP:0005388 9.43 RAPSN STK11 TUBB2B AQP1 AQP3 FGFR3
8 vision/eye MP:0005391 9.1 AQP1 AQP3 CNTNAP1 FGFR3 HSD17B4 STK11

Drugs & Therapeutics for Polyhydramnios

Drugs for Polyhydramnios (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 4 10238-21-8 3488
2
Metformin Approved Phase 4 657-24-9 14219 4091
3 Hypoglycemic Agents Phase 4
4
Betamethasone Approved, Vet_approved Phase 1, Phase 2 378-44-9 9782
5 Anti-Asthmatic Agents Phase 1, Phase 2
6 Anti-Inflammatory Agents Phase 1, Phase 2
7 Betamethasone benzoate Phase 1, Phase 2
8 Betamethasone sodium phosphate Phase 1, Phase 2
9 Betamethasone Valerate Phase 1, Phase 2 2152-44-5
10 Betamethasone-17,21-dipropionate Phase 1, Phase 2
11 glucocorticoids Phase 1, Phase 2
12 Hormone Antagonists Phase 1, Phase 2
13 Hormones Phase 1, Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
15 Respiratory System Agents Phase 1, Phase 2
16
Insulin Detemir Approved 169148-63-4 5311023
17
Zinc Approved 7440-66-6 32051 23994
18
Cholecalciferol Approved, Nutraceutical 67-97-0 6221 10883523 5280795
19
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
20
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
21 Bone Density Conservation Agents
22 Calcium, Dietary
23 Ergocalciferols
24 Micronutrients
25 Trace Elements
26 Vitamins
27 Pharmaceutical Solutions
28 insulin
29 Insulin, Globin Zinc
30 Insulin, Isophane
31 Insulin, Long-Acting
32 Insulin, Short-Acting
33 Isophane insulin, beef
34 Isophane Insulin, Human
35 Calciferol Nutraceutical
36 Vitamin D2 Nutraceutical

Interventional clinical trials:

(show all 13)

id Name Status NCT ID Phase Drugs
1 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
2 Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia Unknown status NCT01240057 Phase 2, Phase 3
3 Syringe or Continuous Amnioreduction for Symptomatic Polyhydramnios. A Prospective Randomized Study. Completed NCT00236340 Phase 3
4 Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM) Terminated NCT00670956 Phase 1, Phase 2 Betamethasone;Placebo
5 Sonographic Assessment of Fetal Deglutition Associated With Hydramnion:Its Absence is Indicative of Central Nervous System (CNS) Pathology Unknown status NCT00687752
6 Vitamin D Treatment and Hypocalcemic Pregnant Women Unknown status NCT02021864 vitamin D3 50,000 unit;prenatal multivitamin
7 Studying Fetal Breathing Patterns Completed NCT00066976
8 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy Completed NCT01375439
9 Chewing Gums to Stimulate Intestinal Motility After Cesarean Section Completed NCT02386748
10 Glycemic Control Using Insulin Levemir Versus Insulin NPH for Diabetes in Pregnancy Completed NCT01837680 Insulin
11 One Step Versus Two Step Approach for Gestational Diabetes Mellitus Screening Recruiting NCT03073330
12 Does Amniotic Fluid Index Affect the Fetal Cardiac Performance? Not yet recruiting NCT03277417
13 The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies Not yet recruiting NCT02732717

Search NIH Clinical Center for Polyhydramnios

Cochrane evidence based reviews: polyhydramnios

Genetic Tests for Polyhydramnios

Genetic tests related to Polyhydramnios:

id Genetic test Affiliating Genes
1 Polyhydramnios 29

Anatomical Context for Polyhydramnios

MalaCards organs/tissues related to Polyhydramnios:

39
Placenta, Lung, Bone, Kidney, Brain, Heart, Fetal Lung

Publications for Polyhydramnios

Articles related to Polyhydramnios:

(show top 50) (show all 333)
id Title Authors Year
1
Prenatal drainage of fetal urinoma with polyhydramnios: a case report and literature review. ( 28076981 )
2017
2
Isolated polyhydramnios in the third trimester: is a gestational diabetes evaluation of value?() ( 28488900 )
2017
3
Pregnant woman with polyhydramnios and fetus with small intestinal atresia. ( 28925193 )
2017
4
Delivery outcomes of term pregnancy complicated by idiopathic polyhydramnios. ( 28643663 )
2017
5
Polyhydramnios - frequency of congenital anomalies in relation to the value of the amniotic fluid index. ( 28930371 )
2017
6
Perinatal outcome in pregnancy with polyhydramnios in comparison with normal pregnancy in department of obstetrics at Shiraz University of Medical Sciences. ( 28462606 )
2017
7
Outcome of pregnancy in women diagnosed with idiopathic polyhydramnios. ( 28251633 )
2017
8
Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation. ( 28620499 )
2017
9
Polyhydramnios or Excessive Fetal Growth Are Markers for Abnormal Perinatal Outcome in Euglycemic Pregnancies. ( 28838004 )
2017
10
Amount of polyhydramnios attributable to diabetes may be less than previously reported. ( 28138359 )
2017
11
Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations. ( 27120771 )
2016
12
EP21.17: Amnioreduction procedure for singleton pregnancies complicated by polyhydramnios causing maternal discomfort. ( 27647433 )
2016
13
Fetal hypothyroidism induced by maternal anti-TSH receptor blocking antibodies and complicated by polyhydramnios despite the absence of goiter. Treatment by intra-amniotic injections of levothyroxine. ( 27919402 )
2016
14
Molecular cytogenetic characterization of inv dup del(8p) in a fetus associated with ventriculomegaly, hypoplastic left heart, polyhydramnios and intestinal obstruction. ( 27343326 )
2016
15
Outcomes From Polyhydramnios With Normal Ultrasound. ( 26755694 )
2016
16
Mode of delivery among women admitted with polyhydramnios. ( 28019126 )
2016
17
Can the Myocardial Performance Index Be Used as a New Predictive Factor for a Poor Prognosis in Fetuses With Idiopathic Polyhydramnios? ( 27821651 )
2016
18
Hyperechogenic kidneys and polyhydramnios associated with HNF1B gene mutation. ( 27286685 )
2016
19
Polyhydramnios and cerebellar atrophy: a prenatal presentation of mitochondrial encephalomyopathy caused by mutations in the FBXL4 gene. ( 27099744 )
2016
20
Prevalence of a positive TORCH and parvovirus B19 screening in pregnancies complicated by polyhydramnios. ( 26970557 )
2016
21
QUESTION 1: Should the passage of a nasogastric tube be universal to all babies born to mothers with polyhydramnios or targeted to those with additional findings on ultrasound? ( 27540183 )
2016
22
Variable genetic penetrance of myotonic dystrophy following the diagnosis of idiopathic polyhydramnios. ( 27039051 )
2016
23
Pregnancy after oocyte donation in 45, X Turner syndrome women, complicated by gestational diabetes and polyhydramnios. Case report and mini-review of literature. ( 26942946 )
2016
24
Polyhydramnios in isolated oral cleft pregnancies: incidence and outcome in a retrospective study. ( 27943390 )
2016
25
Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. ( 26847765 )
2016
26
Prenatal ultrasound factors and genetic disorders in pregnancies complicated by polyhydramnios. ( 27247190 )
2016
27
Prenatal Diagnosis and Pregnancy Outcome Analysis of Polyhydramnios. ( 26720631 )
2016
28
Foetal biometry in polyhydramnios: Does femur length fall behind? ( 26467094 )
2016
29
A Case of the TOF with APV Complicated with Polyhydramnios and Severe Bronchomalacia. ( 27579200 )
2016
30
Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE). ( 27170158 )
2016
31
Transient antenatal Bartter's Syndrome and X-linked polyhydramnios: insights from theA genetics of a rare condition. ( 27633862 )
2016
32
Pregnancy outcomes in severe polyhydramnios: no increase in risk in patients needing amnioreduction for maternal pain or respiratory distress. ( 26948899 )
2016
33
Idiopathic polyhydramnios at term and pregnancy outcomes: a multicenter observational study. ( 27625160 )
2016
34
Idiopathic polyhydramnios: persistence across gestation and impact on pregnancy outcomes. ( 26937648 )
2016
35
Idiopathic Polyhydramnios: Severity and Perinatal Morbidity. ( 26862725 )
2016
36
Intrapartum, postpartum characteristics and early neonatal outcomes of idiopathic polyhydramnios. ( 26926000 )
2016
37
Rapid Resolution of Polyhydramnios Foretells Circulatory Collapse for the Donor Twin in Feto-Fetal Transfusion Syndrome. ( 26932285 )
2016
38
Amniotic fluid biochemistry in isolated polyhydramnios: a series of 464 cases. ( 26426702 )
2015
39
Perinatal Outcome in Idiopathic Polyhydramnios. ( 26405400 )
2015
40
Decreased umbilical orexin-A level is associated with idiopathic polyhydramnios. ( 25494826 )
2015
41
Acute polyhydramnios after maternal status epilepticus. ( 26331018 )
2015
42
Reply to "Questions about and speculations on the incidence of idiopathic polyhydramnios by fetal gender". ( 25786638 )
2015
43
Polyhydramnios associated with Prader-Willi syndrome. ( 26271012 )
2015
44
Questions about and speculations on the incidence of idiopathic polyhydramnios by fetal gender. ( 25786637 )
2015
45
Polyhydramnios associated with Prader-Willi syndrome. ( 26291428 )
2015
46
Association of isolated polyhydramnios at or beyond 34 weeks of gestation and pregnancy outcome. ( 25751210 )
2015
47
Placental tumor (chorioangioma) as a cause of polyhydramnios: a case report. ( 25429242 )
2014
48
Polyhydramnios in the sac of the parasitic twin: atypical manifestation of twin reversed arterial perfusion sequence. ( 25510847 )
2014
49
Predictive value of second and third trimester fetal renal artery Doppler indices in idiopathic oligohydramnios and polyhydramnios in low-risk pregnancies: A longitudinal study. ( 25363086 )
2014
50
Midtrimester isolated polyhydramnios in monochorionic diamniotic multiple gestations. ( 24858201 )
2014

Variations for Polyhydramnios

Expression for Polyhydramnios

Search GEO for disease gene expression data for Polyhydramnios.

Pathways for Polyhydramnios

Pathways related to Polyhydramnios according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.58 STK11 STRADA
2 10.26 CLCNKB KCNJ1 SLC12A1

GO Terms for Polyhydramnios

Biological processes related to Polyhydramnios according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 potassium ion transport GO:0006813 9.5 AQP1 KCNJ1 SLC12A1
2 positive regulation of protein serine/threonine kinase activity GO:0071902 9.43 STK11 STRADA
3 odontogenesis GO:0042476 9.4 AQP1 AQP3
4 renal water homeostasis GO:0003091 9.37 AQP1 AQP3
5 water transport GO:0006833 9.26 AQP1 AQP3
6 glycerol transport GO:0015793 9.16 AQP1 AQP3
7 renal water absorption GO:0070295 8.96 AQP1 AQP3
8 excretion GO:0007588 8.8 AQP3 CLCNKB KCNJ1

Molecular functions related to Polyhydramnios according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein kinase activator activity GO:0030295 8.96 STK11 STRADA
2 water channel activity GO:0015250 8.62 AQP1 AQP3

Sources for Polyhydramnios

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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