MCID: PLY040
MIFTS: 35

Polymorphous Low-Grade Adenocarcinoma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

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Aliases & Descriptions for Polymorphous Low-Grade Adenocarcinoma:

Name: Polymorphous Low-Grade Adenocarcinoma 46
 
Polymorphous Low Grade Adenocarcinoma 66

Classifications:



Summaries for Polymorphous Low-Grade Adenocarcinoma

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Wikipedia:69 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

MalaCards based summary: Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to adenocarcinoma and xq12-q13.3 duplication syndrome. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways are Advanced glycosylation endproduct receptor signaling and C-MYB transcription factor network. Affiliated tissues include salivary gland, tongue and lung, and related mouse phenotypes are digestive/alimentary and muscle.

Related Diseases for Polymorphous Low-Grade Adenocarcinoma

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Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma11.0
2xq12-q13.3 duplication syndrome10.8ACTC1, KIT
3pemphigus vulgaris, familial10.8CEACAM3, MUC1
4lymphangiomatosis10.7ACTC1, VIM
5ovarian cyst10.7KIT, MUC1
6myxoid liposarcoma of the ovary10.7ACTC1, VIM
7aml with myelodysplasia-related features10.7KIT, MYH11
8distal monosomy 7q3610.7MUC1, VIM
9iridogoniodysgenesis and skeletal anomalies10.6ACTC1, VIM
10transitional meningioma10.6MUC1, VIM
11skin lipoma10.6ACTC1, VIM
12bartholin's gland adenoid cystic carcinoma10.6KIT, NFIB
13ovarian stromal hyperthecosis10.6MUC1, TP63
14monophasic synovial sarcoma10.6MUC1, VIM
15adenoiditis10.6
16skin sarcoma10.5ACTC1, MUC1, VIM
17mollaret meningitis10.5ACTC1, VIM
18ovarian cystadenocarcinoma10.5ACTC1, MUC1, VIM
19benign mesenchymoma10.5MUC1, TP63, VIM
20congenital structural myopathy10.5MUC1, VIM
21intravascular fasciitis10.5ACTC1, MUC1, S100A1
22paranasal sinus cancer, adult10.5ACTC1, CEACAM3, VIM
23vulvar alveolar soft part sarcoma10.5ACTC1, TP63, VIM
24staphyloenterotoxemia10.5ACTC1, MUC1, VIM
25chronic end-stage hepatitis c10.5KIT, VIM
26hing torack dowston syndrome10.5CEACAM3, MKI67, MUC1
27malignant glandular tumor of peripheral nerve sheath10.5ACTC1, NTRK3, VIM
28placental site trophoblastic tumor10.5ACTC1, MKI67, MUC1
29plethora of newborn10.4CTNNB1, MUC1
30sarcomatoid renal cell carcinoma10.4KIT, S100A1
31bronchial neoplasm10.4MUC1, VIM
322q33.1 microdeletion syndrome10.4MUC1, S100A1, VIM
33pediatric meningioma10.4LGALS3, MUC1, VIM
34transverse colon cancer10.4ACTC1, CTNNB1
35water-clear cell adenoma10.4MUC1, SERPINB5, TP63
36adenoma10.3
37pura syndrome10.3ACTC1, KIT, MKI67
38vascular hemostatic disease10.3ACTC1, MUC1, TP63, VIM
39follicular adenoma10.3MUC1, S100A1, VIM
40breast pericanalicular fibroadenoma10.3KIT, MKI67, MUC1
41extracranial neuroblastoma10.3MKI67, MUC1, VIM
42esophageal tuberculosis10.3CTNNB1, NTRK3
43amelogenesis imperfecta local hypoplastic10.3MKI67, TP63, VIM
44gorham's disease10.3MKI67, MUC1, VIM
45logopenic progressive aphasia10.3MUC1, S100B
46intermediate dend syndrome10.3MUC1, S100B
47mucinous stomach adenocarcinoma10.3CTNNB1, MKI67
48pleomorphic adenoma10.3
49lyme disease - neurological complications10.2MUC1, S100B
50parachordoma10.2ACTC1, KIT, MUC1, VIM

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to polymorphous low-grade adenocarcinoma

Symptoms for Polymorphous Low-Grade Adenocarcinoma

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Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Polymorphous Low-Grade Adenocarcinoma

Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

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Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

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MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

34
Salivary gland, Tongue, Lung, Lymph node, Trachea, Pituitary, Breast

Animal Models for Polymorphous Low-Grade Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma:

39 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4CCND1, CTNNB1, KIT, LGALS3, MYH11, NFIB
2MP:00053698.4ACTC1, CTNNB1, KIT, MYH11, S100A1, TP63
3MP:00053918.2CCND1, CTNNB1, KIT, NFIB, NTRK3, TP63
4MP:00107718.0CCND1, CTNNB1, KIT, LGALS3, MYB, MYH11
5MP:00053787.4ACTC1, CCND1, CTNNB1, KIT, MYB, MYH11
6MP:00053887.3CCND1, CTNNB1, KIT, LGALS3, MYH11, NFIB
7MP:00053847.0ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB
8MP:00053856.9ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB
9MP:00107686.8ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB
10MP:00053766.6ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYH11
11MP:00028736.5ACTC1, CCND1, CTNNB1, KIT, MKI67, MYB

Publications for Polymorphous Low-Grade Adenocarcinoma

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Articles related to Polymorphous Low-Grade Adenocarcinoma:

(show top 50)    (show all 170)
idTitleAuthorsYear
1
Polymorphous Low-Grade Adenocarcinoma of the Palate: A Rare Case Report. (27366306)
2016
2
Polymorphous low-grade adenocarcinoma of the epiglottis: A case report. (27123278)
2016
3
Doing more with less: the challenging diagnosis of polymorphous low-grade adenocarcinoma in incisional biopsy samples. (26408830)
2015
4
Polymorphous Low-Grade Adenocarcinoma of the Oral Cavity. (26413969)
2015
5
Immunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinoma. (26671844)
2015
6
Polymorphous low-grade adenocarcinoma. (24452888)
2014
7
Oral and maxillofacial pathology. Case of the month. Polymorphous low-grade adenocarcinoma. (25163215)
2014
8
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (24265903)
2013
9
Polymorphous low-grade adenocarcinoma of the maxillary sinus. (23714964)
2013
10
Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. (24268388)
2013
11
Polymorphous Low-Grade Adenocarcinoma (PLGA) in an 18-Year-Old Male. (24426416)
2013
12
Polymorphous low-grade adenocarcinoma--management and reconstruction with temporalis myofacial flap. (24431823)
2013
13
Polymorphous low-grade adenocarcinoma located in the maxillary sinus. (23011832)
2012
14
Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. (21901247)
2012
15
Intraosseous polymorphous low-grade adenocarcinoma of mandible: A rare entity. (23162596)
2012
16
Polymorphous low-grade adenocarcinoma of the parotid gland. (21546751)
2011
17
Polymorphous low-grade adenocarcinoma of the nasopharynx: a case report and brief review. (18820100)
2008
18
Low-grade papillary adenocarcinoma of the palate: the significance of distinguishing it from polymorphous low-grade adenocarcinoma. (20614302)
2008
19
Polymorphous low-grade adenocarcinoma of the head and neck. (18327037)
2008
20
Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. (16996782)
2007
21
Application of alpha-smooth muscle actin and c-kit in the differential diagnosis of adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. (16807072)
2007
22
Primary polymorphous low-grade adenocarcinoma of lung treated by sleeve bronchial resection: a case report. (17449954)
2007
23
Polymorphous low grade adenocarcinoma: review and case report. (18059236)
2007
24
Retrospective study and review of polymorphous low-grade adenocarcinoma. (17146387)
2006
25
Polymorphous low-grade adenocarcinoma of the nasal fossa. (16056192)
2005
26
Polymorphous low-grade adenocarcinoma of the palate: report of cases. (15963668)
2005
27
Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas. (15153875)
2004
28
Polymorphous low-grade adenocarcinoma of the major salivary glands: report of three cases in an unusual location. (14764060)
2004
29
Polymorphous low-grade adenocarcinoma--a rare and aggressive entity in adolescence. (15121262)
2004
30
Polymorphous low grade adenocarcinoma of the parotid gland. Cytological, histological and immunohistochemical features and review of the literature. (15168873)
2004
31
Polymorphous low-grade adenocarcinoma of the tongue. (15041060)
2004
32
Polymorphous low-grade adenocarcinoma of the lacrimal gland. (15197069)
2004
33
Cytomorphology of polymorphous low grade adenocarcinoma--diagnosis and pitfalls. (15025286)
2003
34
Polymorphous low-grade adenocarcinoma of the vulva and vagina: a tumor resembling adenoid cystic carcinoma. (12598921)
2003
35
Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: distinct architectural composition revealed by collagen IV, laminin and their integrin ligands (alpha2beta1 and alpha3beta1). (10931234)
2000
36
Polymorphous low grade adenocarcinoma with distant metastases and deletions on chromosome 6q23-qter and 11q23-qter: a case report. (11265182)
2000
37
Polymorphous low-grade adenocarcinoma of the submandibular gland. (10964318)
2000
38
Histologic transformation of polymorphous low-grade adenocarcinoma of salivary gland. (10361514)
1999
39
Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases. (10421256)
1999
40
Polymorphous low-grade adenocarcinoma of the parotid gland. (9758181)
1998
41
Polymorphous low-grade adenocarcinoma of the parotid gland. (9825934)
1998
42
Polymorphous low-grade adenocarcinoma: flow cytometric, p53, and PCNA analysis. (9347503)
1997
43
Regional metastasis in polymorphous low grade adenocarcinoma. Report of a case. (9418148)
1997
44
Polymorphous low-grade adenocarcinoma of the tongue. (8759555)
1996
45
Simultaneous multifocal polymorphous low-grade adenocarcinoma. Report of two cases. (7552866)
1995
46
Clinical and therapeutic features of polymorphous low-grade adenocarcinoma. (8108096)
1994
47
Argyrophilia in nucleolar organizer regions (AgNOR) in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of the salivary glands. (7690237)
1993
48
Polymorphous low-grade adenocarcinoma. (1607159)
1992
49
Polymorphous low-grade adenocarcinoma of the salivary glands: a clinicopathological comparison with adenoid cystic carcinoma. (1661700)
1991
50
Polymorphous low-grade adenocarcinoma of minor salivary glands. A study of 14 cases of a distinctive neoplasm. (6692293)
1984

Variations for Polymorphous Low-Grade Adenocarcinoma

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Expression for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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GO Terms for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Cellular components related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00057375.7ACTC1, CCND1, CTNNB1, KIT, LGALS3, MKI67

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.6MUC1, TP63
2mitotic G1 DNA damage checkpointGO:003157110.3CCND1, TP63
3regulation of T cell proliferationGO:00421299.9CTNNB1, LGALS3
4positive regulation of histone H3-K4 methylationGO:00515719.7CTNNB1, MYB
5epithelial cell differentiationGO:00308559.4LGALS3, MUC1, TP63
6positive regulation of gene expressionGO:00106288.7ACTC1, CTNNB1, KIT, NTRK3, VIM
7positive regulation of cell proliferationGO:00082848.3CCND1, CTNNB1, KIT, NTRK3, S100B

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00020399.9MUC1, NTRK3, TP63
2S100 protein bindingGO:00445489.8S100A1, S100B
3double-stranded DNA bindingGO:00036909.4CTNNB1, NFIB, TP63

Sources for Polymorphous Low-Grade Adenocarcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet