MCID: PLY040
MIFTS: 37

Polymorphous Low-Grade Adenocarcinoma

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

MalaCards integrated aliases for Polymorphous Low-Grade Adenocarcinoma:

Name: Polymorphous Low-Grade Adenocarcinoma 50
Polymorphous Low Grade Adenocarcinoma 69

Classifications:



Summaries for Polymorphous Low-Grade Adenocarcinoma

MalaCards based summary : Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to adenocarcinoma and lymphocytic hypophysitis. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are MicroRNAs in cancer and DNA Damage. The drugs Gemcitabine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, tongue and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and cardiovascular system

Wikipedia : 72 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

Related Diseases for Polymorphous Low-Grade Adenocarcinoma

Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
id Related Disease Score Top Affiliating Genes
1 adenocarcinoma 10.9
2 lymphocytic hypophysitis 10.9 ACTC1 VIM
3 gastric signet ring cell adenocarcinoma 10.8 ACTC1 VIM
4 marfanoid habitus-inguinal hernia-advanced bone age syndrome 10.8 ACTC1 KIT
5 aortic aneurysm 10.8 ACTC1 VIM
6 iridogoniodysgenesis and skeletal anomalies 10.8 ACTC1 VIM
7 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 10.8 MUC1 VIM
8 esophagus leiomyosarcoma 10.8 ACTC1 VIM
9 skin lipoma 10.7 ACTC1 VIM
10 logopenic progressive aphasia 10.7 MUC1 S100B
11 pseudomyxoma peritonei 10.7 KIT VIM
12 heiner syndrome 10.7 MUC1 S100B
13 uniparental disomy of chromosome 11 10.7 ACTC1 VIM
14 vulvar angiokeratoma 10.7 MUC1 VIM
15 meningitis and encephalitis 10.7 MUC1 S100B
16 laryngeal neuroendocrine tumor 10.7 ACTC1 MUC1 VIM
17 immune-mediated encephalomyelitis 10.7 S100B VIM
18 lymphangiosarcoma 10.7 ACTC1 MUC1 VIM
19 myxoid leiomyosarcoma 10.7 ACTC1 VIM
20 thyroid dyshormonogenesis 1 10.7 ACTC1 CEACAM3 MUC1
21 2q31.1 microdeletion syndrome 10.7 MUC1 S100A1 VIM
22 berk-tabatznik syndrome 10.7 ACTC1 VIM
23 group b strep disease in newborns 10.7 ACTC1 CEACAM3 VIM
24 mannose-binding lectin protein deficiency 10.7 KIT MUC1 VIM
25 pyoderma 10.7 MUC1 VIM
26 benallegue lacete syndrome 10.7 S100B VIM
27 simple cryoglobulinemia 10.7 MUC1 S100B
28 esophagus leiomyoma 10.7 ACTC1 MUC1 VIM
29 localized pulmonary fibrosis 10.7 ACTC1 S100B
30 situs inversus totalis with cystic dysplasia of kidneys and pancreas 10.7 CEACAM3 MKI67 MUC1
31 hemangioma of liver 10.7 ACTC1 S100B
32 cellular ependymoma 10.7 MUC1 VIM
33 diffuse meningeal melanocytosis 10.7 KIT MUC1 VIM
34 serous cystadenocarcinoma 10.7 CEACAM3 MUC1 VIM
35 cerebrum cancer 10.6 ACTC1 MUC1 VIM
36 mucinous ovarian cystadenoma 10.6 MUC1 S100B
37 bladder colloid adenocarcinoma 10.6 MKI67 MUC1 VIM
38 mesothelioma, somatic 10.6 CEACAM3 MUC1 VIM
39 neurogenic thoracic outlet syndrome 10.6 S100B VIM
40 enteric pattern testicular yolk sac tumor 10.6 MUC1 S100B
41 preretinal fibrosis 10.6 ACTC1 MUC1 VIM
42 thymic dysplasia 10.6 MUC1 TP63
43 large cell acanthoma 10.6 ACTC1 KIT VIM
44 mediastinal osteogenic sarcoma 10.6 MUC1 S100A1 VIM
45 chikungunya 10.6 KIT MUC1 VIM
46 amelogenesis imperfecta local hypoplastic 10.6 MKI67 TP63 VIM
47 hyperpituitarism 10.6 ACTC1 S100A1 VIM
48 punctate palmoplantar keratoderma type 2 10.6 ACTC1 KIT MKI67
49 noninvasive malignant thymoma 10.6 MUC1 S100B VIM
50 reticular pattern testicular yolk sac tumor 10.6 MUC1 S100B VIM

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to Polymorphous Low-Grade Adenocarcinoma

Symptoms & Phenotypes for Polymorphous Low-Grade Adenocarcinoma

GenomeRNAi Phenotypes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.98 MYB
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.98 NFIB VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.98 CTNNB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.98 CTNNB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.98 NFIB
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.98 MYB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.98 MYB
8 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.98 MYB
9 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.98 CCND1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.98 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.98 MYB
12 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.98 CCND1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.98 CCND1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.98 MYB
15 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.98 CCND1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.98 MYB
17 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.98 MYB
18 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.98 VIM
19 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.98 MYB CCND1 NFIB CTNNB1 VIM
20 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.98 VIM
21 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.98 VIM
22 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.98 CTNNB1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.98 CCND1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.98 CCND1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.98 CCND1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.98 CCND1 NFIB
27 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.98 VIM
28 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.98 VIM
29 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.98 NFIB
30 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.98 CCND1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.98 CTNNB1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.98 CTNNB1
33 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.98 VIM
34 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.98 CTNNB1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.98 CTNNB1 MYB
36 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.98 CTNNB1
37 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.98 CTNNB1
38 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.98 MYB
39 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.98 VIM

MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.22 VIM S100A1 TP63 NTRK3 CTNNB1 MYB
2 cellular MP:0005384 10.2 VIM S100A1 SERPINB5 TP63 CTNNB1 MYB
3 behavior/neurological MP:0005386 10.15 NTRK3 VIM S100A1 S100B TP63 LGALS3
4 homeostasis/metabolism MP:0005376 10.14 VIM S100A1 S100B MYH11 NFIB TP63
5 mortality/aging MP:0010768 10.1 NTRK3 VIM SERPINB5 TP63 NFIB CTNNB1
6 digestive/alimentary MP:0005381 9.98 MYH11 NFIB TP63 LGALS3 CTNNB1 KIT
7 integument MP:0010771 9.97 S100B MYH11 TP63 CTNNB1 MYB KIT
8 normal MP:0002873 9.9 S100A1 S100B SERPINB5 TP63 NTRK3 CTNNB1
9 muscle MP:0005369 9.8 VIM S100A1 MYH11 TP63 CTNNB1 ACTC1
10 respiratory system MP:0005388 9.65 S100A1 TP63 NFIB NTRK3 VIM CTNNB1
11 vision/eye MP:0005391 9.17 NTRK3 VIM NFIB TP63 CCND1 CTNNB1

Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

Drugs for Polymorphous Low-Grade Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 2 95058-81-4 60750
2 Anti-Infective Agents Phase 2
3 Antimetabolites Phase 2
4 Antimetabolites, Antineoplastic Phase 2
5 Antiviral Agents Phase 2
6 Immunosuppressive Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery Completed NCT00003744 Phase 2 gemcitabine

Search NIH Clinical Center for Polymorphous Low-Grade Adenocarcinoma

Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

39
Salivary Gland, Tongue, Lung, Lymph Node, Trachea, Pituitary, Skin

Publications for Polymorphous Low-Grade Adenocarcinoma

Articles related to Polymorphous Low-Grade Adenocarcinoma:

(show top 50) (show all 174)
id Title Authors Year
1
Establishment of a primary culture of polymorphous low grade adenocarcinoma cells. ( 28647648 )
2017
2
Factors that may influence polymorphous low-grade adenocarcinoma growth. ( 28188441 )
2017
3
Advancing toward a molecular characterization of polymorphous low grade adenocarcinoma. ( 28939261 )
2017
4
Cribriform adenocarcinoma of minor salivary gland: A mimic of polymorphous low-grade adenocarcinoma. ( 27721624 )
2016
5
Polymorphous low-grade adenocarcinoma: A Danish national study. ( 27016011 )
2016
6
Plasmacytoid-Type Cellular Differentiation in Polymorphous Low-Grade Adenocarcinoma. ( 26912473 )
2016
7
Mammaglobin and DOG-1 expression in polymorphous low-grade adenocarcinoma: an appraisal of its origin and morphology. ( 27591391 )
2016
8
Polymorphous Low-Grade Adenocarcinoma of the Palate: A Rare Case Report. ( 27366306 )
2016
9
Polymorphous low-grade adenocarcinoma of the epiglottis: A case report. ( 27123278 )
2016
10
Predictors of Outcome in the Phenotypic Spectrum of Polymorphous Low-grade Adenocarcinoma (PLGA) and Cribriform Adenocarcinoma of Salivary Gland (CASG): A Retrospective Study of 69 Patients. ( 27454943 )
2016
11
Case report of polymorphous low-grade adenocarcinoma in the trachea with metastasis to the right middle lobe bronchus. ( 26273362 )
2015
12
Doing more with less: the challenging diagnosis of polymorphous low-grade adenocarcinoma in incisional biopsy samples. ( 26408830 )
2015
13
Polymorphous low grade adenocarcinoma of lip clinically mimicking squamous cell carcinoma: An unusual presentation. ( 25948951 )
2015
14
Polymorphous low-grade adenocarcinoma of the head and neck: A population-based study of 460 cases. ( 25877006 )
2015
15
Immunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinoma. ( 26671844 )
2015
16
Polymorphous low grade adenocarcinoma. ( 26097312 )
2015
17
A case report of a pulmonary metastasis of a polymorphous low-grade adenocarcinoma. ( 25693921 )
2015
18
Polymorphous low-grade adenocarcinoma of the upper lip: 11 cases of an uncommon diagnosis. ( 25747177 )
2015
19
Polymorphous Low Grade Adenocarcinoma of Retromolar Region - A Rare Case Report with Distinct Clinical Manifestations. ( 26266226 )
2015
20
Polymorphous Low-Grade Adenocarcinoma of the Oral Cavity. ( 26413969 )
2015
21
Polymorphous low-grade adenocarcinoma of the tongue base treated by transoral robotic surgery. ( 25954561 )
2015
22
Histopathological spectrum of polymorphous low-grade adenocarcinoma. ( 26604510 )
2015
23
Immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands. ( 24910675 )
2014
24
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. ( 25240283 )
2014
25
PRKD1 Mutations Characterize Salivary Gland Polymorphous Low-Grade Adenocarcinoma. ( 25367945 )
2014
26
Polymorphous low-grade adenocarcinoma. ( 24452888 )
2014
27
Surface Papillary Epithelial Hyperplasia (Rough Mucosa) is a Helpful Clue for Identification of Polymorphous Low-Grade Adenocarcinoma. ( 25322702 )
2014
28
Polymorphous low-grade adenocarcinoma: A case series and determination of recurrence. ( 25229805 )
2014
29
Polymorphous Low Grade Adenocarcinoma has a Consistent p63+/p40- Immunophenotype that Helps Distinguish it from Adenoid Cystic Carcinoma and Cellular Pleomorphic Adenoma. ( 24969705 )
2014
30
Oral and maxillofacial pathology. Case of the month. Polymorphous low-grade adenocarcinoma. ( 25163215 )
2014
31
Proton beam therapy and continuous intra-arterial chemotherapy for polymorphous low-grade adenocarcinoma in the hard palate. ( 23466803 )
2013
32
Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. ( 24268388 )
2013
33
Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists. ( 23320410 )
2013
34
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. ( 24265903 )
2013
35
Cytomorphological features of an aggressive variant of polymorphous low-grade adenocarcinoma in adolescence with lymph node metastasis. ( 22144102 )
2013
36
Polymorphous low-grade adenocarcinoma: a 17 patient case series. ( 23618791 )
2013
37
Fine needle aspiration cytology of metastatic polymorphous low-grade adenocarcinoma of the palate in a cervical lymph node. ( 21883542 )
2013
38
Polymorphous low-grade adenocarcinoma--management and reconstruction with temporalis myofacial flap. ( 24431823 )
2013
39
Polymorphous low-grade adenocarcinoma of the maxillary sinus. ( 23714964 )
2013
40
Polymorphous low-grade adenocarcinoma of the larynx: a rare case report. ( 23981163 )
2013
41
Polymorphous low-grade adenocarcinoma of maxillary alveolus metastasising to the abdomen: the role of immunomarkers in diagnosis. ( 23661663 )
2013
42
Polymorphous Low-Grade Adenocarcinoma (PLGA) in an 18-Year-Old Male. ( 24426416 )
2013
43
Polymorphous low-grade adenocarcinoma: a case report. ( 22184472 )
2013
44
Polymorphous Low-grade Adenocarcinoma of the Head and Neck. ( 23428952 )
2013
45
Polymorphous low-grade adenocarcinoma in the upper lip: a well-described but infrequently recognized tumor. ( 24021444 )
2013
46
Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin I+vI^3 in pleomorphic adenoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma. ( 24237725 )
2013
47
Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. ( 21901247 )
2012
48
Polymorphous low-grade adenocarcinoma located in the maxillary sinus. ( 23011832 )
2012
49
Intraosseous polymorphous low-grade adenocarcinoma of mandible: A rare entity. ( 23162596 )
2012
50
Morphological heterogeneity of oral salivary gland carcinomas: a clinicopathologic study of 41 cases with long term follow-up emphasizing the overlapping spectrum of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. ( 21577319 )
2011

Variations for Polymorphous Low-Grade Adenocarcinoma

Expression for Polymorphous Low-Grade Adenocarcinoma

Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for Polymorphous Low-Grade Adenocarcinoma

GO Terms for Polymorphous Low-Grade Adenocarcinoma

Cellular components related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.44 ACTC1 CCND1 CTNNB1 KIT LGALS3 MKI67

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.77 CCND1 CTNNB1 KIT NTRK3 S100B
2 response to ethanol GO:0045471 9.65 ACTC1 CCND1 NTRK3
3 positive regulation of histone H3-K4 methylation GO:0051571 9.46 CTNNB1 MYB
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.43 MUC1 TP63
5 epithelial cell differentiation GO:0030855 9.43 LGALS3 MUC1 TP63
6 response to corticosterone GO:0051412 9.4 CCND1 NTRK3
7 cellular response to retinoic acid GO:0071300 9.33 MUC1 MYB NTRK3
8 mitotic G1 DNA damage checkpoint GO:0031571 9.32 CCND1 TP63
9 positive regulation of gene expression GO:0010628 9.02 ACTC1 CTNNB1 KIT NTRK3 VIM
10 regulation of T cell proliferation GO:0042129 8.96 CTNNB1 LGALS3

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 9.33 CTNNB1 NFIB TP63
2 S100 protein binding GO:0044548 8.96 S100A1 S100B
3 p53 binding GO:0002039 8.8 MUC1 NTRK3 TP63

Sources for Polymorphous Low-Grade Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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