MCID: PLY040
MIFTS: 36

Polymorphous Low-Grade Adenocarcinoma malady

Summaries for Polymorphous Low-Grade Adenocarcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

MalaCards: Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to adenocarcinoma and adenoid cystic carcinoma. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is SERPINB5 (serpin peptidase inhibitor, clade B (ovalbumin), member 5), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Striated Muscle Contraction. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

polymorphous low-grade adenocarcinoma 42
polymorphous low grade adenocarcinoma 60


Related Diseases for Polymorphous Low-Grade Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.8TP63, CEACAM3, ESR1, SERPINB5, LGALS3, ACTC1
2adenoid cystic carcinoma31.2TP63, CEACAM3, SERPINB5, LGALS3, ACTC1, KIT
3adenoma30.9TP63, CEACAM3, SERPINB5, LGALS3, ACTC1, PCNA
4pleomorphic adenoma30.7TP63, SERPINB5, ACTC1, PCNA, MUC1, MYH11
5lung adenocarcinoma30.6TP63, CEACAM3, MUC1, NTRK3, CTNNB1, CCND1
6basal cell carcinoma30.5TP63, LGALS3, ACTC1, CTNNB1
7cystadenocarcinoma30.3CEACAM3, MUC1
8cervical adenocarcinoma30.3ESR1
9cribriform carcinoma30.3TP63, ESR1, KIT
10myoepithelioma30.3TP63, SERPINB5, ACTC1, S100A1, S100B, VIM
11papillary carcinoma30.3TP63, CEACAM3, ESR1, SERPINB5, LGALS3, ACTC1
12adenoiditis10.9
13papillary adenocarcinoma10.4
14cystic basal cell carcinoma10.4
15maxillary sinus adenocarcinoma10.4
16adenoid basal cell carcinoma10.4
17pleomorphic adenoma carcinoma10.2
18papillary cystadenocarcinoma10.2
19pleomorphic carcinoma10.2
20nasopharyngitis10.2
21tonsillitis10.2
22nasal cavity adenocarcinoma10.2
23adenocarcinoma in situ10.2
24breast adenocarcinoma10.2
25cervicitis10.2
26lacrimal gland adenocarcinoma10.2
27vulva adenocarcinoma10.2
28hemangioma10.0ACTC1
29pericardial effusion10.0CHKB
30hepatitis c10.0MYB
31fasciitis10.0ACTC1
32asthma10.0CHKB
33cystadenoma10.0CEACAM3
34renal oncocytoma10.0S100A1
35histiocytosis10.0S100B
36gallbladder cancer10.0CEACAM3
37uterine carcinosarcoma10.0KIT
38hepatitis b10.0MYB
39nephrogenic adenoma10.0S100A1
40lipoma10.0S100A1
41sertoli-leydig cell tumor10.0MUC1
42cholestasis10.0CEACAM3
43anaplastic large cell lymphoma10.0MUC1
44psoriasis10.0S100A1
45germ cell tumors10.0KIT
46myotonic dystrophy10.0CHKB
47liposarcoma10.0VIM
48seminoma10.0KIT
49myelodysplastic syndromes10.0KIT
50pheochromocytoma10.0NTRK3

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to polymorphous low-grade adenocarcinoma

Clinical Features for Polymorphous Low-Grade Adenocarcinoma

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Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Polymorphous Low-Grade Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Polymorphous Low-Grade Adenocarcinoma

Search NIH Clinical Center for Polymorphous Low-Grade Adenocarcinoma

Search CenterWatch for Polymorphous Low-Grade Adenocarcinoma

Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

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Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

32
Salivary gland

Animal Models for Polymorphous Low-Grade Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.0MYH11, LGALS3
2MP:00053799.9KIT, CCND1
3MP:00053699.6ESR1, ACTC1, CHKB, MYH11
4MP:00053809.4TP63, SERPINB5, VIM
5MP:00053899.3CTNNB1, CCND1, PCNA
6MP:00053909.3CCND1, TP63, LGALS3, CHKB
7MP:00107719.3MYB, CCND1, S100B, CTNNB1, MYH11
8MP:00053919.0MUC1, NFIB, NTRK3, VIM
9MP:00053768.7ESR1, CHKB, NFIB, MYH11, ACTC1
10MP:00020068.5MUC1, CCND1, CTNNB1, KIT, ESR1, TP63
11MP:00036318.5KIT, CHKB, NFIB, LGALS3, NTRK3
12MP:00030128.2PCNA, KIT, ESR1, MUC1, MYB, NTRK3
13MP:00053818.2TP63, ESR1, LGALS3, KIT, MUC1, MYH11
14MP:00053887.9CTNNB1, CCND1, NFIB, TP63, ESR1, NTRK3
15MP:00028737.6CCND1, S100B, ACTC1, MUC1, MYB, NTRK3
16MP:00053877.6CCND1, TP63, LGALS3, KIT, PCNA, MYB
17MP:00053847.3MYB, KIT, ACTC1, LGALS3, SERPINB5, CTNNB1
18MP:00053867.3ESR1, VIM, TP63, S100B, S100A1, CCND1
19MP:00053856.9TP63, VIM, CCND1, S100A1, CTNNB1, NTRK3
20MP:00053786.2MYB, NFIB, PCNA, KIT, ACTC1, ESR1
21MP:00107685.9MYB, SERPINB5, VIM, NFIB, CCND1, TP63

Publications for Polymorphous Low-Grade Adenocarcinoma

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Genetic Variations for Polymorphous Low-Grade Adenocarcinoma

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Expression for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CHKB
2butyrate4410.6MYB
3estradiol44 11 2412.1MYB, CHKB, VIM
4cycloheximide4410.0NTRK3
5orcein449.9VIM, ACTC1, S100B
6s 100449.9S100B, MUC1, ACTC1, VIM
7serine449.7MYH11, S100B, CCND1
8creatinine449.6CHKB, ACTC1, CEACAM3
9eosin449.6MUC1, PCNA, VIM, S100B
102-methoxyethanol449.5S100A1, ACTC1, TP63, VIM
11glycogen44 2410.4CCND1, CTNNB1, CHKB, ACTC1, KIT
12dexamethasone44 49 28 1112.4CTNNB1, MYB, PCNA, S100B
13reticulin449.3PCNA, MUC1, S100B, VIM, ACTC1
14paclitaxel44 49 1111.3ESR1, CTNNB1, S100B, CCND1
15glutamine449.3CHKB, PCNA, CTNNB1, LGALS3, MYB
16dihydrotestosterone44 28 11 2412.2VIM, ESR1, CHKB
17trastuzumab44 49 1111.0CTNNB1, CCND1, MUC1, ESR1, KIT
184-hydroxytamoxifen449.0VIM, CCND1, S100B, CTNNB1, ESR1
19gefitinib44 49 1111.0ESR1, KIT, CTNNB1, CCND1, VIM
20agar449.0CHKB, LGALS3, MUC1, VIM, CTNNB1, CCND1
21roscovitine448.9CCND1, VIM, CTNNB1, PCNA
22imatinib44 49 1110.8CCND1, S100B, CTNNB1, MYB, KIT, ACTC1
23biotin44 11 2410.7ACTC1, VIM, CTNNB1, MUC1, PCNA, S100A1
24adriamycin448.6CEACAM3, MUC1, VIM, CTNNB1, CCND1
25steroid448.5MYB, SERPINB5, ESR1, CCND1, CHKB, CEACAM3
26bromodeoxyuridine448.5VIM, PCNA, MYB, CTNNB1, S100B, TP63
27formaldehyde44 249.5VIM, CCND1, S100B, MUC1, PCNA, ACTC1
28mucicarmine448.4TP63, VIM, S100B, S100A1, MUC1, ACTC1
29cisplatin44 49 59 1111.4CTNNB1, MUC1, PCNA, SERPINB5, TP63, LGALS3
30lactate448.4PCNA, CEACAM3, LGALS3, VIM, KIT, S100B
31arginine448.3MYB, VIM, CTNNB1, TP63, PCNA, CHKB
32matrigel448.3NTRK3, CCND1, MUC1, CTNNB1, LGALS3, SERPINB5
33threonine448.3NTRK3, S100B, CTNNB1, MYB, MUC1, KIT
345fluorouracil448.3CEACAM3, ESR1, PCNA, MUC1, KIT, CTNNB1
35nitric oxide44 11 2410.0KIT, LGALS3, CHKB, MUC1, MYH11, CEACAM3
36aspartate448.0CHKB, NTRK3, PCNA, CEACAM3, S100B, CTNNB1
37doxorubicin44 49 119.9TP63, CEACAM3, ESR1, KIT, MYB, CTNNB1
38b 723447.9VIM, S100B, S100A1, MUC1, PCNA, ACTC1
39methotrexate44 49 119.8CEACAM3, ESR1, KIT, PCNA, MUC1, CHKB
40alanine447.8S100B, CTNNB1, MYB, VIM, PCNA, LGALS3
41cysteine447.7CTNNB1, S100A1, MYB, VIM, MUC1, LGALS3
42tamoxifen44 49 28 1110.5MUC1, CCND1, VIM, PCNA, CHKB, CTNNB1
43thymidine44 248.4CHKB, CTNNB1, MYB, KIT, PCNA, MUC1
44hematoxylin447.2PCNA, KIT, ACTC1, LGALS3, CEACAM3, TP63
45tyrosine446.9NTRK3, CCND1, S100A1, S100B, MYB, MUC1
46testosterone44 59 11 249.8S100B, CTNNB1, CHKB, NTRK3, MUC1, PCNA
47retinoic acid44 247.0LGALS3, ACTC1, KIT, PCNA, MUC1, MYB
48progesterone44 59 28 11 249.5CEACAM3, ESR1, SERPINB5, LGALS3, ACTC1, KIT
49paraffin445.5CHKB, CTNNB1, VIM, CCND1, S100B, S100A1
50vegf445.4TP63, CEACAM3, CTNNB1, S100B, CCND1, VIM

GO Terms for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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16Gene Ontology
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Cellular components related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.0TP63, S100B, CTNNB1, CHKB, NTRK3, MUC1

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9TP63, MUC1
2positive regulation of phospholipase C activityGO:0108639.8ESR1, KIT
3epithelial cell developmentGO:0020649.8TP63, ESR1
4response to ethanolGO:0454719.5ACTC1, NTRK3, CCND1
5mitotic G1 DNA damage checkpointGO:0315719.4TP63, CCND1
6negative regulation of transcription from RNA polymerase II promoterGO:0001228.1S100A1, CTNNB1, NFIB, MYB, TP63

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.7S100A1, S100B
2p53 bindingGO:0020399.2TP63, MUC1, NTRK3
3identical protein bindingGO:0428028.1TP63, ESR1, PCNA, S100A1, S100B, VIM
4protein bindingGO:0055155.8MYH11, CTNNB1, S100A1, S100B, CCND1, VIM

Products for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Sources for Polymorphous Low-Grade Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet