MCID: PLY040
MIFTS: 38

Polymorphous Low-Grade Adenocarcinoma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

Aliases & Descriptions for Polymorphous Low-Grade Adenocarcinoma:

Name: Polymorphous Low-Grade Adenocarcinoma 50
Polymorphous Low Grade Adenocarcinoma 69

Classifications:



Summaries for Polymorphous Low-Grade Adenocarcinoma

MalaCards based summary : Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to adenocarcinoma and adenoiditis. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are MicroRNAs in cancer and DNA Damage. The drugs Gemcitabine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, tongue and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and cardiovascular system

Wikipedia : 71 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

Related Diseases for Polymorphous Low-Grade Adenocarcinoma

Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
id Related Disease Score Top Affiliating Genes
1 adenocarcinoma 10.9
2 adenoiditis 10.4
3 lymphomatoid papulosis 10.3 ACTC1 VIM
4 chest wall parachordoma 10.3 ACTC1 VIM
5 lucey-driscoll syndrome 10.3 MUC1 S100B
6 carbon monoxide-induced parkinsonism 10.3 ACTC1 KIT
7 secondary pulmonary hemosiderosis 10.3 MUC1 S100B
8 isolated anterior cervical hypertrichosis 10.3 ACTC1 VIM
9 lymphangiosarcoma 10.3 ACTC1 MUC1 VIM
10 coronary stenosis 10.3 ACTC1 MUC1 VIM
11 vagina leiomyosarcoma 10.3 ACTC1 MUC1
12 marfanoid hypermobility syndrome 10.3 KIT MUC1 VIM
13 skeletal-extraskeletal angiomatosis 10.3 CEACAM3 MKI67 MUC1
14 lung benign neoplasm 10.3 ACTC1 MUC1 VIM
15 lupus - neurological sequelae 10.3 S100B VIM
16 growth retardation hydrocephaly lung hypoplasia 10.3 ACTC1 CEACAM3 VIM
17 autosomal recessive stickler syndrome 10.3 MUC1 S100A1 VIM
18 orthostatic proteinuria 10.3 ACTC1 MUC1 VIM
19 mucinous cystadenocarcinoma 10.3 ACTC1 MKI67 MUC1
20 myelinoclastic diffuse sclerosis 10.3 MUC1 S100B
21 bladder adenocarcinoma 10.3 MKI67 MUC1 VIM
22 intracranial sinus thrombosis 10.3 KIT VIM
23 kidney benign neoplasm 10.3 CEACAM3 MUC1 VIM
24 pilar sheath acanthoma 10.2 ACTC1 KIT VIM
25 subependymal glioma 10.2 MKI67 MUC1 VIM
26 ovarian papillary neoplasm 10.2 MUC1 S100A1 VIM
27 aml with myelodysplasia-related features 10.2 MKI67 TP63 VIM
28 benign schwannoma 10.2 S100B VIM
29 pustulosis palmaris et plantaris 10.2 ACTC1 KIT MKI67
30 biliary papillomatosis 10.2 MUC1 S100B VIM
31 postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma 10.2 MUC1 S100B VIM
32 preretinal fibrosis 10.2 ACTC1 MUC1 VIM
33 human granulocytic anaplasmosis 10.2 KIT MUC1 VIM
34 microinvasive cervical squamous cell carcinoma 10.2 MUC1 S100B VIM
35 subglottis verrucous carcinoma 10.2 MUC1 S100B VIM
36 clear cell ependymoma 10.2 MUC1 S100B VIM
37 behcet's syndrome arthropathy 10.2 MUC1 S100B VIM
38 sternum cancer 10.2 MUC1 S100B VIM
39 invasive mole 10.2 KIT MUC1 S100B
40 hyperpituitarism 10.2 ACTC1 S100A1 VIM
41 aneurysm of sinus of valsalva 10.2 MUC1 S100B VIM
42 lung combined type small cell carcinoma 10.2 MUC1 SERPINB5 TP63
43 adenoma 10.2
44 osteomyelitis 10.2 ACTC1 VIM
45 gastrointestinal system cancer 10.2 MUC1 S100B VIM
46 dyslexia 10.2 ACTC1 S100B VIM
47 childhood brain germinoma 10.2 MUC1 S100B VIM
48 chiasmal syndrome 10.2 ACTC1 S100B
49 congenital myasthenic syndrome 10.2 ACTC1 VIM
50 testicular granulosa cell tumor 10.2 ACTC1 MUC1 TP63 VIM

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to Polymorphous Low-Grade Adenocarcinoma

Symptoms & Phenotypes for Polymorphous Low-Grade Adenocarcinoma

GenomeRNAi Phenotypes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.98 MYB
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.98 NFIB VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.98 CTNNB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.98 CTNNB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.98 NFIB
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.98 MYB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.98 MYB
8 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.98 MYB
9 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.98 CCND1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.98 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.98 MYB
12 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.98 CCND1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.98 CCND1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.98 MYB
15 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.98 CCND1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.98 MYB
17 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.98 MYB
18 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.98 VIM
19 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.98 CCND1 NFIB CTNNB1 VIM MYB
20 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.98 VIM
21 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.98 VIM
22 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.98 CTNNB1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.98 CCND1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.98 CCND1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.98 CCND1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.98 CCND1 NFIB
27 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.98 VIM
28 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.98 VIM
29 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.98 NFIB
30 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.98 CCND1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.98 CTNNB1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.98 CTNNB1
33 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.98 VIM
34 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.98 CTNNB1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.98 CTNNB1 MYB
36 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.98 CTNNB1
37 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.98 CTNNB1
38 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.98 MYB
39 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.98 VIM

MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.22 NTRK3 S100A1 TP63 VIM ACTC1 CCND1
2 cellular MP:0005384 10.2 ACTC1 CCND1 CTNNB1 KIT LGALS3 MYB
3 homeostasis/metabolism MP:0005376 10.14 TP63 VIM ACTC1 CCND1 CTNNB1 KIT
4 mortality/aging MP:0010768 10.1 ACTC1 CCND1 CTNNB1 KIT LGALS3 MYB
5 digestive/alimentary MP:0005381 9.98 CCND1 CTNNB1 KIT LGALS3 MYH11 NFIB
6 integument MP:0010771 9.97 KIT LGALS3 MYB MYH11 S100B TP63
7 normal MP:0002873 9.9 ACTC1 CCND1 CTNNB1 KIT MKI67 MYB
8 muscle MP:0005369 9.8 ACTC1 CTNNB1 KIT MYH11 S100A1 TP63
9 respiratory system MP:0005388 9.65 CCND1 CTNNB1 KIT LGALS3 MYH11 NFIB
10 vision/eye MP:0005391 9.17 CCND1 CTNNB1 KIT NFIB NTRK3 TP63

Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

Drugs for Polymorphous Low-Grade Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 2 95058-81-4 60750
2 Anti-Infective Agents Phase 2
3 Immunosuppressive Agents Phase 2
4 Antimetabolites Phase 2
5 Antimetabolites, Antineoplastic Phase 2
6 Antiviral Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery Completed NCT00003744 Phase 2

Search NIH Clinical Center for Polymorphous Low-Grade Adenocarcinoma

Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

39
Salivary Gland, Tongue, Lung, Lymph Node, Trachea, Pituitary, Breast

Publications for Polymorphous Low-Grade Adenocarcinoma

Articles related to Polymorphous Low-Grade Adenocarcinoma:

(show top 50) (show all 171)
id Title Authors Year
1
Mammaglobin and DOG-1 expression in polymorphous low-grade adenocarcinoma: an appraisal of its origin and morphology. ( 27591391 )
2016
2
Polymorphous low-grade adenocarcinoma: A Danish national study. ( 27016011 )
2016
3
Polymorphous low-grade adenocarcinoma of the epiglottis: A case report. ( 27123278 )
2016
4
Cribriform adenocarcinoma of minor salivary gland: A mimic of polymorphous low-grade adenocarcinoma. ( 27721624 )
2016
5
Predictors of Outcome in the Phenotypic Spectrum of Polymorphous Low-grade Adenocarcinoma (PLGA) and Cribriform Adenocarcinoma of Salivary Gland (CASG): A Retrospective Study of 69 Patients. ( 27454943 )
2016
6
Polymorphous Low-Grade Adenocarcinoma of the Palate: A Rare Case Report. ( 27366306 )
2016
7
Plasmacytoid-Type Cellular Differentiation in Polymorphous Low-Grade Adenocarcinoma. ( 26912473 )
2016
8
Polymorphous Low-Grade Adenocarcinoma of the Oral Cavity. ( 26413969 )
2015
9
Immunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinoma. ( 26671844 )
2015
10
Polymorphous low grade adenocarcinoma of lip clinically mimicking squamous cell carcinoma: An unusual presentation. ( 25948951 )
2015
11
Polymorphous low-grade adenocarcinoma of the upper lip: 11 cases of an uncommon diagnosis. ( 25747177 )
2015
12
Doing more with less: the challenging diagnosis of polymorphous low-grade adenocarcinoma in incisional biopsy samples. ( 26408830 )
2015
13
Histopathological spectrum of polymorphous low-grade adenocarcinoma. ( 26604510 )
2015
14
A case report of a pulmonary metastasis of a polymorphous low-grade adenocarcinoma. ( 25693921 )
2015
15
Polymorphous Low Grade Adenocarcinoma of Retromolar Region - A Rare Case Report with Distinct Clinical Manifestations. ( 26266226 )
2015
16
Polymorphous low-grade adenocarcinoma of the tongue base treated by transoral robotic surgery. ( 25954561 )
2015
17
Polymorphous low-grade adenocarcinoma of the head and neck: A population-based study of 460 cases. ( 25877006 )
2015
18
Case report of polymorphous low-grade adenocarcinoma in the trachea with metastasis to the right middle lobe bronchus. ( 26273362 )
2015
19
Polymorphous low grade adenocarcinoma. ( 26097312 )
2015
20
Immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands. ( 24910675 )
2014
21
PRKD1 Mutations Characterize Salivary Gland Polymorphous Low-Grade Adenocarcinoma. ( 25367945 )
2014
22
Polymorphous Low Grade Adenocarcinoma has a Consistent p63+/p40- Immunophenotype that Helps Distinguish it from Adenoid Cystic Carcinoma and Cellular Pleomorphic Adenoma. ( 24969705 )
2014
23
Surface Papillary Epithelial Hyperplasia (Rough Mucosa) is a Helpful Clue for Identification of Polymorphous Low-Grade Adenocarcinoma. ( 25322702 )
2014
24
Polymorphous low-grade adenocarcinoma: A case series and determination of recurrence. ( 25229805 )
2014
25
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. ( 25240283 )
2014
26
Polymorphous low-grade adenocarcinoma. ( 24452888 )
2014
27
Oral and maxillofacial pathology. Case of the month. Polymorphous low-grade adenocarcinoma. ( 25163215 )
2014
28
Polymorphous Low-Grade Adenocarcinoma (PLGA) in an 18-Year-Old Male. ( 24426416 )
2013
29
Cytomorphological features of an aggressive variant of polymorphous low-grade adenocarcinoma in adolescence with lymph node metastasis. ( 22144102 )
2013
30
Polymorphous low-grade adenocarcinoma in the upper lip: a well-described but infrequently recognized tumor. ( 24021444 )
2013
31
Polymorphous low-grade adenocarcinoma of maxillary alveolus metastasising to the abdomen: the role of immunomarkers in diagnosis. ( 23661663 )
2013
32
Polymorphous low-grade adenocarcinoma of the larynx: a rare case report. ( 23981163 )
2013
33
Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin I+vI^3 in pleomorphic adenoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma. ( 24237725 )
2013
34
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. ( 24265903 )
2013
35
Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists. ( 23320410 )
2013
36
Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. ( 24268388 )
2013
37
Fine needle aspiration cytology of metastatic polymorphous low-grade adenocarcinoma of the palate in a cervical lymph node. ( 21883542 )
2013
38
Polymorphous low-grade adenocarcinoma: a case report. ( 22184472 )
2013
39
Polymorphous low-grade adenocarcinoma of the maxillary sinus. ( 23714964 )
2013
40
Polymorphous low-grade adenocarcinoma: a 17 patient case series. ( 23618791 )
2013
41
Polymorphous Low-grade Adenocarcinoma of the Head and Neck. ( 23428952 )
2013
42
Proton beam therapy and continuous intra-arterial chemotherapy for polymorphous low-grade adenocarcinoma in the hard palate. ( 23466803 )
2013
43
Polymorphous low-grade adenocarcinoma--management and reconstruction with temporalis myofacial flap. ( 24431823 )
2013
44
Intraosseous polymorphous low-grade adenocarcinoma of mandible: A rare entity. ( 23162596 )
2012
45
Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. ( 21901247 )
2012
46
Polymorphous low-grade adenocarcinoma located in the maxillary sinus. ( 23011832 )
2012
47
Polymorphous low-grade adenocarcinoma of the palate: report of a case. ( 22293274 )
2011
48
Morphological heterogeneity of oral salivary gland carcinomas: a clinicopathologic study of 41 cases with long term follow-up emphasizing the overlapping spectrum of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. ( 21577319 )
2011
49
Polymorphous low grade adenocarcinoma: case series and review of surgical management. ( 21288614 )
2011
50
Polymorphous low-grade adenocarcinoma of the parotid gland. ( 21546751 )
2011

Variations for Polymorphous Low-Grade Adenocarcinoma

Expression for Polymorphous Low-Grade Adenocarcinoma

Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for Polymorphous Low-Grade Adenocarcinoma

GO Terms for Polymorphous Low-Grade Adenocarcinoma

Cellular components related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.44 ACTC1 CCND1 CTNNB1 KIT LGALS3 MKI67

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.72 CCND1 CTNNB1 KIT NTRK3 S100B
2 response to ethanol GO:0045471 9.65 ACTC1 CCND1 NTRK3
3 response to corticosterone GO:0051412 9.46 CCND1 NTRK3
4 positive regulation of histone H3-K4 methylation GO:0051571 9.43 CTNNB1 MYB
5 epithelial cell differentiation GO:0030855 9.43 LGALS3 MUC1 TP63
6 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.4 MUC1 TP63
7 mitotic G1 DNA damage checkpoint GO:0031571 9.37 CCND1 TP63
8 cellular response to retinoic acid GO:0071300 9.33 MUC1 MYB NTRK3
9 positive regulation of gene expression GO:0010628 9.02 ACTC1 CTNNB1 KIT NTRK3 VIM
10 regulation of T cell proliferation GO:0042129 8.96 CTNNB1 LGALS3

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.56 CTNNB1 MUC1 MYB NFIB
2 double-stranded DNA binding GO:0003690 9.33 CTNNB1 NFIB TP63
3 S100 protein binding GO:0044548 8.96 S100A1 S100B
4 p53 binding GO:0002039 8.8 MUC1 NTRK3 TP63

Sources for Polymorphous Low-Grade Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
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54 OMIM
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60 QIAGEN
65 SNOMED-CT via Orphanet
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68 Tocris
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70 UMLS via Orphanet
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