MCID: PLY040
MIFTS: 50

Polymorphous Low-Grade Adenocarcinoma malady

Rare diseases category

Summaries for Polymorphous Low-Grade Adenocarcinoma

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Wikipedia:65 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

MalaCards based summary: Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to adenocarcinoma and adenoma. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is SERPINB5 (serpin peptidase inhibitor, clade B (ovalbumin), member 5), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Lymphocyte Signaling. The compounds s 100 and orcein have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, tongue and lung, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

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Polymorphous Low-Grade Adenocarcinoma, Aliases & Descriptions:

Name: Polymorphous Low-Grade Adenocarcinoma 43
 
Polymorphous Low Grade Adenocarcinoma 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Polymorphous Low-Grade Adenocarcinoma

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Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.7CTNNB1, PCNA, ACTC1, NTRK3, CCND1, LGALS3
2adenoma31.0CTNNB1, S100A1, PCNA, ACTC1, CCND1, LGALS3
3pleomorphic adenoma30.9S100B, S100A1, PCNA, ACTC1, MUC1, MYH11
4cystadenocarcinoma30.5CEACAM3, MUC1
5salivary gland adenoid cystic carcinoma30.5NFIB, MYB
6myoepithelioma30.4S100B, S100A1, ACTC1, VIM, SERPINB5, TP63
7adenoiditis11.0
8nasopharyngitis10.3
9tonsillitis10.3
10papillary cystadenocarcinoma10.3
11adenocarcinoma in situ10.3
12cervicitis10.3
13nephrogenic adenoma10.1S100A1
14pericardial effusion10.1CHKB
15multicystic dysplastic kidney10.1LGALS3
16histiocytosis10.1S100B
17hidradenoma10.1MUC1
18carney triad10.1KIT
19juvenile xanthogranuloma10.1S100B
20cholesteatoma10.1S100A1, LGALS3
21langerhans-cell histiocytosis10.1S100B, S100A1
22rosai-dorfman disease10.1S100B
23epithelioid leiomyosarcoma10.1ACTC1, VIM
24fibrous meningioma10.0S100B, MUC1
25clear cell ependymoma10.0MUC1, VIM
26anaplastic ependymoma10.0S100B, MUC1
27choroid plexus papilloma10.0S100B, MUC1
28mucinous cystadenocarcinoma10.0CEACAM3, MUC1
29mesenchymal chondrosarcoma10.0MUC1, VIM
30paget disease, extramammary10.0CEACAM3, MUC1
31adenomatoid tumor10.0VIM
32cutaneous fibrous histiocytoma10.0S100B, S100A1, ACTC1
33glomus tumor10.0S100A1, ACTC1, VIM
34clear cell sarcoma10.0KIT, S100B
35fibroma10.0S100A1, ACTC1, VIM
36sertoli cell tumor10.0MUC1, VIM
37epithelioid sarcoma10.0MUC1, VIM
38intraductal papilloma10.0MYH11, TP63
39pulmonary alveolar proteinosis10.0CEACAM3, MUC1
40congenital mesoblastic nephroma10.0NTRK3
41granular cell tumor10.0S100B, S100A1, VIM
42secretory meningioma10.0MUC1, VIM
43paraganglioma10.0KIT, S100B, S100A1
44ectopic pregnancy10.0CHKB, MYH11
45rhabdoid tumor10.0ACTC1, MUC1, VIM
46fibrous histiocytoma10.0S100B, ACTC1, VIM
47renal clear cell carcinoma10.0S100A1, MUC1, VIM
48angiosarcoma10.0ACTC1, MUC1, VIM
49perineurioma10.0S100B, MUC1, VIM
50cholangiocarcinoma10.0LGALS3, CEACAM3, MUC1

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to polymorphous low-grade adenocarcinoma

Symptoms for Polymorphous Low-Grade Adenocarcinoma

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Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

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Drug clinical trials:

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Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

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Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

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MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

33
Salivary gland, Tongue, Lung, Lymph node, Smooth muscle, Breast, Skin, Tonsil, Pituitary

Animal Models for Polymorphous Low-Grade Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma:

37 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8CTNNB1, KIT, CHKB, ESR1, TP63
2MP:00020068.6TP63, ESR1, MUC1, CCND1, KIT, CTNNB1
3MP:00053678.5TP63, ESR1, MYH11, LGALS3, KIT, CTNNB1
4MP:00053908.4TP63, ESR1, CHKB, LGALS3, CCND1, KIT
5MP:00053808.4TP63, SERPINB5, ESR1, VIM, MYB, KIT
6MP:00053818.3TP63, ESR1, MYH11, MUC1, LGALS3, CCND1
7MP:00030128.2ESR1, MYB, MUC1, NTRK3, PCNA, KIT
8MP:00053798.1TP63, ESR1, MUC1, CCND1, PCNA, KIT
9MP:00053897.9TP63, ESR1, VIM, LGALS3, CCND1, PCNA
10MP:00053847.8VIM, ESR1, SERPINB5, TP63, MYB, LGALS3
11MP:00053697.8TP63, ESR1, VIM, MYH11, CHKB, ACTC1
12MP:00107717.8TP63, ESR1, MYB, MYH11, MUC1, LGALS3
13MP:00053917.7TP63, VIM, MUC1, CCND1, NTRK3, KIT
14MP:00053877.7TP63, ESR1, VIM, MYB, LGALS3, CCND1
15MP:00028737.6CCND1, MUC1, MYB, TP63, NTRK3, ACTC1
16MP:00053977.5ESR1, VIM, MYB, LGALS3, CCND1, PCNA
17MP:00053867.3TP63, ESR1, VIM, CHKB, CCND1, NTRK3
18MP:00036317.2ESR1, VIM, CHKB, LGALS3, CCND1, NTRK3
19MP:00053887.0MYH11, VIM, ESR1, TP63, LGALS3, CCND1
20MP:00053856.9CTNNB1, TP63, ESR1, VIM, MYB, MYH11
21MP:00053766.7MUC1, MYH11, VIM, ESR1, TP63, CHKB
22MP:00053786.3MYH11, MYB, VIM, ESR1, TP63, CCND1
23MP:00107685.9MYH11, MYB, VIM, ESR1, SERPINB5, TP63

Publications for Polymorphous Low-Grade Adenocarcinoma

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Articles related to Polymorphous Low-Grade Adenocarcinoma:

(show top 50)    (show all 152)
idTitleAuthorsYear
1
Immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands. (24910675)
2014
2
Polymorphous low-grade adenocarcinoma. (24452888)
2014
3
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (24265903)
2013
4
Polymorphous low-grade adenocarcinoma of the maxillary sinus. (23714964)
2013
5
Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. (24268388)
2013
6
Polymorphous Low-Grade Adenocarcinoma (PLGA) in an 18-Year-Old Male. (24426416)
2013
7
Polymorphous low-grade adenocarcinoma located in the maxillary sinus. (23011832)
2012
8
Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. (21901247)
2012
9
Polymorphous low-grade adenocarcinoma: the University of Pittsburgh experience. (20403856)
2010
10
Polymorphous low-grade adenocarcinoma of parotid gland: a rare occurrence. (19136798)
2009
11
Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (20032601)
2009
12
Polymorphous low-grade adenocarcinoma of the nasopharynx: a case report and brief review. (18820100)
2008
13
Polymorphous low-grade adenocarcinoma of the head and neck. (18327037)
2008
14
Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. (16996782)
2007
15
Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma. (16487803)
2006
16
Retrospective study and review of polymorphous low-grade adenocarcinoma. (17146387)
2006
17
Polymorphous low-grade adenocarcinoma of the nasal fossa. (16056192)
2005
18
Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas. (15153875)
2004
19
Polymorphous low-grade adenocarcinoma of the major salivary glands: report of three cases in an unusual location. (14764060)
2004
20
Polymorphous low-grade adenocarcinoma--a rare and aggressive entity in adolescence. (15121262)
2004
21
Polymorphous low grade adenocarcinoma of the parotid gland. Cytological, histological and immunohistochemical features and review of the literature. (15168873)
2004
22
Polymorphous low-grade adenocarcinoma of the tongue. (15041060)
2004
23
Polymorphous low-grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma. (12207787)
2002
24
Cytogenetic similarities between two types of salivary gland carcinomas: adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (11463451)
2001
25
Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: distinct architectural composition revealed by collagen IV, laminin and their integrin ligands (alpha2beta1 and alpha3beta1). (10931234)
2000
26
Polymorphous low grade adenocarcinoma with distant metastases and deletions on chromosome 6q23-qter and 11q23-qter: a case report. (11265182)
2000
27
Polymorphous low-grade adenocarcinoma of the submandibular gland. (10964318)
2000
28
Histologic transformation of polymorphous low-grade adenocarcinoma of salivary gland. (10361514)
1999
29
Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases. (10421256)
1999
30
Characterization of the cellular component of polymorphous low-grade adenocarcinoma by immunohistochemistry and electron microscopy. (10435151)
1999
31
Polymorphous low-grade adenocarcinoma of the parotid gland. (9758181)
1998
32
Polymorphous low-grade adenocarcinoma of the parotid gland. (9825934)
1998
33
Polymorphous low-grade adenocarcinoma: flow cytometric, p53, and PCNA analysis. (9347503)
1997
34
Regional metastasis in polymorphous low grade adenocarcinoma. Report of a case. (9418148)
1997
35
Polymorphous low-grade adenocarcinoma (PLGA) of the tongue. (9102454)
1997
36
Assessment of proliferative activity using the MIB1 antibody help to distinguish polymorphous low grade adenocarcinoma from adenoid cystic carcinoma of salivary glands. (9505262)
1997
37
Polymorphous low-grade adenocarcinoma of the palate in a 16-year-old male patient. (8971451)
1996
38
Polymorphous low-grade adenocarcinoma of parotid gland. (8866071)
1996
39
Case presentation. Polymorphous low-grade adenocarcinoma: a minor salivary gland malignancy with benign clinical features. (9569846)
1996
40
Simultaneous multifocal polymorphous low-grade adenocarcinoma. Report of two cases. (7552866)
1995
41
Polymorphous low-grade adenocarcinoma arising in the nasal cavities with an associated undifferentiated carcinoma. (7483012)
1995
42
Clinical and therapeutic features of polymorphous low-grade adenocarcinoma. (8108096)
1994
43
Argyrophilia in nucleolar organizer regions (AgNOR) in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of the salivary glands. (7690237)
1993
44
Polymorphous low-grade adenocarcinoma. (1607159)
1992
45
Polymorphous low-grade adenocarcinoma: a 'new' salivary gland tumour. (2008296)
1991
46
Polymorphous low-grade adenocarcinoma of the salivary glands: a clinicopathological comparison with adenoid cystic carcinoma. (1661700)
1991
47
Karyotypic variability and evolutionary characteristics of a polymorphous low grade adenocarcinoma in the parotid gland. (1913603)
1991
48
Case for diagnosis. Polymorphous low-grade adenocarcinoma of minor salivary gland origin. (3133600)
1988
49
Polymorphous low-grade adenocarcinoma of minor salivary gland. An immunohistochemical and clinicopathologic study. (2837102)
1988
50
Polymorphous low-grade adenocarcinoma of minor salivary glands. A study of 14 cases of a distinctive neoplasm. (6692293)
1984

Variations for Polymorphous Low-Grade Adenocarcinoma

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Expression for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Pathways related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0S100B, LGALS3
29.8KIT, LGALS3, MYB
3
Show member pathways
9.7ACTC1, MYH11, VIM
49.7CCND1, ESR1
59.6CCND1, LGALS3, VIM
69.6KIT, CCND1, MYB
79.4PCNA, SERPINB5, TP63
89.3TP63, SERPINB5, VIM, CCND1
99.3ESR1, CCND1, CTNNB1
109.3CTNNB1, CCND1, ESR1
119.3ESR1, CCND1, CTNNB1
129.0MYB, CCND1, PCNA, CTNNB1
13
Show member pathways
Signal transduction PTEN pathway60
9.0CCND1, PCNA, KIT, CTNNB1
14
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
8.8MYH11, CCND1, NTRK3, ACTC1, CTNNB1
158.8CTNNB1, PCNA, CCND1, ESR1
16
Show member pathways
8.7ESR1, VIM, NTRK3, KIT, CTNNB1
17
Show member pathways
7.8CTNNB1, ESR1, VIM, MYH11, MUC1, CCND1

Compounds for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Compounds related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1s 100459.9VIM, MUC1, ACTC1, S100B
2orcein459.6S100B, ACTC1, VIM
3eosin459.6VIM, MUC1, PCNA, S100B
42-methoxyethanol459.5S100A1, ACTC1, VIM, TP63
5reticulin459.4VIM, MUC1, ACTC1, PCNA, S100B
6trastuzumab45 51 1311.1ESR1, MUC1, CCND1, KIT, CTNNB1
74-hydroxytamoxifen459.1ESR1, VIM, CCND1, S100B, CTNNB1
8agar459.0VIM, MUC1, CHKB, LGALS3, CCND1, CTNNB1
9gefitinib45 51 1311.0ESR1, VIM, CCND1, KIT, CTNNB1
10imatinib45 51 1310.8MYB, CCND1, NTRK3, ACTC1, S100B, KIT
11biotin45 26 1310.7VIM, MUC1, ACTC1, PCNA, S100A1, CTNNB1
12butyrate458.6VIM, MYB, MUC1, LGALS3, CCND1, PCNA
13adriamycin458.6VIM, MUC1, CEACAM3, CCND1, CTNNB1
14dihydrotestosterone45 30 26 1311.6ESR1, VIM, MUC1, CHKB, CTNNB1
15formaldehyde45 269.6VIM, MUC1, LGALS3, CCND1, ACTC1, PCNA
16bromodeoxyuridine458.5TP63, VIM, MYB, CCND1, PCNA, S100B
17glutamine458.5VIM, MYB, CHKB, LGALS3, PCNA, S100B
18estradiol45 26 1310.5ESR1, VIM, MYB, MUC1, CHKB, CCND1
19mucicarmine458.5S100B, S100A1, ACTC1, CEACAM3, MUC1, VIM
20dexamethasone45 51 30 1311.4VIM, MYB, MUC1, CHKB, ACTC1, PCNA
21threonine458.3MYB, MUC1, LGALS3, CCND1, NTRK3, S100B
22lactate458.3VIM, CHKB, CEACAM3, LGALS3, PCNA, S100B
23matrigel458.3TP63, SERPINB5, VIM, MUC1, LGALS3, CCND1
24paclitaxel45 51 1310.3ESR1, VIM, CCND1, PCNA, S100B, KIT
25creatinine458.3VIM, MUC1, CHKB, CEACAM3, ACTC1, PCNA
26arginine458.3TP63, VIM, MYB, CHKB, LGALS3, PCNA
275fluorouracil458.3ESR1, MUC1, CEACAM3, PCNA, KIT, CTNNB1
28oligonucleotide458.3CTNNB1, KIT, PCNA, CCND1, LGALS3, MYB
29cisplatin45 51 61 1311.2TP63, SERPINB5, ESR1, MUC1, LGALS3, CCND1
30cycloheximide458.2ESR1, VIM, MYB, CCND1, NTRK3, KIT
31serine458.0SERPINB5, VIM, MYB, MYH11, MUC1, LGALS3
32nitric oxide45 26 1310.0SERPINB5, MYH11, MUC1, CHKB, CEACAM3, LGALS3
33glycogen45 269.0VIM, MUC1, CHKB, LGALS3, CCND1, ACTC1
34doxorubicin45 51 1310.0TP63, ESR1, VIM, MYB, CEACAM3, CCND1
35b 723457.9S100A1, PCNA, ACTC1, CEACAM3, MUC1, VIM
36methotrexate51 45 139.9ESR1, VIM, MUC1, CHKB, CEACAM3, CCND1
37alanine457.9VIM, MYB, CHKB, CEACAM3, LGALS3, PCNA
38aspartate457.9VIM, CHKB, CEACAM3, NTRK3, PCNA, S100B
39cysteine457.7VIM, MYB, MUC1, CHKB, LGALS3, PCNA
40tamoxifen45 51 30 1310.6PCNA, CCND1, CEACAM3, CHKB, MUC1, VIM
41thymidine45 268.5TP63, MYB, CTNNB1, KIT, S100B, PCNA
42steroid457.4TP63, SERPINB5, ESR1, MYB, CHKB, CEACAM3
43hematoxylin457.2TP63, KIT, S100B, S100A1, PCNA, ACTC1
44tyrosine456.9TP63, MYB, MUC1, CEACAM3, LGALS3, CCND1
45testosterone45 61 26 139.8CTNNB1, KIT, S100B, PCNA, ACTC1, NTRK3
46retinoic acid45 267.0MYH11, MYB, VIM, ESR1, TP63, MUC1
47progesterone45 30 61 26 139.6MYH11, MYB, VIM, ESR1, SERPINB5, TP63
48paraffin455.6VIM, ESR1, SERPINB5, TP63, MYH11, MUC1
49vegf455.5CTNNB1, TP63, SERPINB5, ESR1, KIT, S100B
50estrogen455.3CTNNB1, KIT, S100B, S100A1, PCNA, ACTC1

GO Terms for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Cellular components related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700628.6MUC1, LGALS3, ACTC1, PCNA, CTNNB1, VIM
2cytoplasmGO:00057377.2CTNNB1, TP63, SERPINB5, VIM, MUC1, LGALS3

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.1TP63, MUC1
2mitotic G1 DNA damage checkpointGO:003157110.0CCND1, TP63
3positive regulation of phospholipase C activityGO:001086310.0KIT, ESR1
4epithelial cell developmentGO:000206410.0ESR1, TP63
5response to X-rayGO:00101659.9CCND1, TP63
6mammary gland alveolus developmentGO:00607499.9ESR1, CCND1
7positive regulation of Notch signaling pathwayGO:00457479.8TP63, KIT
8response to corticosteroneGO:00514129.8CCND1, NTRK3
9proximal/distal pattern formationGO:00099549.8CTNNB1, TP63
10response to ethanolGO:00454719.8CCND1, NTRK3, ACTC1
11chromatin remodelingGO:00063389.7TP63, ESR1, MYB
12hindbrain developmentGO:00309029.4CTNNB1, NFIB
13G1/S transition of mitotic cell cycleGO:00000829.4PCNA, CCND1, MYB
14response to cadmium ionGO:00466869.3CTNNB1, PCNA
15positive regulation of transcription from RNA polymerase II promoterGO:00459448.5TP63, ESR1, MYB, NFIB, CTNNB1
16negative regulation of transcription from RNA polymerase II promoterGO:00001228.2CTNNB1, NFIB, S100A1, CCND1, MYB, TP63

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:00445489.6S100A1, S100B
2p53 bindingGO:00020399.5NTRK3, MUC1, TP63
3double-stranded DNA bindingGO:00036909.0CTNNB1, NFIB, TP63
4chromatin bindingGO:00036828.8CTNNB1, MYB, ESR1, TP63
5identical protein bindingGO:00428028.2TP63, ESR1, VIM, PCNA, S100A1, S100B
6protein bindingGO:00055156.1CTNNB1, TP63, SERPINB5, ESR1, VIM, MYB

Products for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Sources for Polymorphous Low-Grade Adenocarcinoma

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4CDC
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16FMA
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27ICD10
28ICD10 via Orphanet
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