MCID: PLY040
MIFTS: 34

Polymorphous Low-Grade Adenocarcinoma malady

Summaries for Polymorphous Low-Grade Adenocarcinoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare,asymptomatic,slow-growing... more...

MalaCards: Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to adenocarcinoma and adenoid cystic carcinoma. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is SERPINB5 (serpin peptidase inhibitor, clade B (ovalbumin), member 5), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Striated Muscle Contraction. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include lung and salivary gland, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

polymorphous low-grade adenocarcinoma 43
polymorphous low grade adenocarcinoma 61


Related Diseases for Polymorphous Low-Grade Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.9TP63, CEACAM3, ESR1, SERPINB5, LGALS3, ACTC1
2adenoid cystic carcinoma31.3TP63, CEACAM3, SERPINB5, LGALS3, ACTC1, KIT
3adenoma30.9TP63, CEACAM3, SERPINB5, LGALS3, ACTC1, PCNA
4pleomorphic adenoma30.7TP63, SERPINB5, ACTC1, PCNA, MUC1, MYH11
5basal cell carcinoma30.5TP63, LGALS3, ACTC1, CTNNB1
6cribriform carcinoma30.3TP63, ESR1, KIT
7myoepithelioma30.3TP63, SERPINB5, ACTC1, S100A1, S100B, VIM
8papillary carcinoma30.3TP63, CEACAM3, ESR1, SERPINB5, LGALS3, ACTC1
9cystic basal cell carcinoma10.4
10maxillary sinus adenocarcinoma10.4
11adenoid basal cell carcinoma10.4
12pleomorphic adenoma carcinoma10.2
13papillary cystadenocarcinoma10.2
14pleomorphic carcinoma10.2
15anal gland adenocarcinoma10.2
16adenocarcinoma in situ10.2
17myoepithelial carcinoma10.2
18breast adenocarcinoma10.2
19vulva adenocarcinoma10.2
20chromosome 11q deletion10.2
21chromosome 6q deletion10.2
22hemangioma10.0ACTC1
23hepatitis c10.0MYB
24pericardial effusion10.0CHKB
25fasciitis10.0ACTC1
26asthma10.0CHKB
27cystadenoma10.0CEACAM3
28renal oncocytoma10.0S100A1
29histiocytosis10.0S100B
30gallbladder cancer10.0CEACAM3
31uterine carcinosarcoma10.0KIT
32hepatitis b10.0MYB
33nephrogenic adenoma10.0S100A1
34lipoma10.0S100A1
35sertoli-leydig cell tumor10.0MUC1
36cholestasis10.0CEACAM3
37anaplastic large cell lymphoma10.0MUC1
38psoriasis10.0S100A1
39germ cell tumors10.0KIT
40myotonic dystrophy10.0CHKB
41liposarcoma10.0VIM
42seminoma10.0KIT
43myelodysplastic syndromes10.0KIT
44pheochromocytoma10.0NTRK3
45ischemia10.0LGALS3, CHKB
46eosinophilia10.0MYH11
47carney triad10.0KIT
48cholesteatoma10.0LGALS3, S100A1
49juvenile xanthogranuloma10.0S100B
50lymphangioleiomyomatosis10.0ESR1

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to polymorphous low-grade adenocarcinoma

Clinical Features for Polymorphous Low-Grade Adenocarcinoma

Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Polymorphous Low-Grade Adenocarcinoma

Drug clinical trials:

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Search NIH Clinical Center for Polymorphous Low-Grade Adenocarcinoma

Search CenterWatch for Polymorphous Low-Grade Adenocarcinoma

Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

33
Lung, Salivary gland

Animal Models for Polymorphous Low-Grade Adenocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.0LGALS3, MYH11
2MP:00053799.9KIT, CCND1
3MP:00053699.6CHKB, MYH11, ACTC1, ESR1
4MP:00053809.4TP63, SERPINB5, VIM
5MP:00053899.3PCNA, CTNNB1, CCND1
6MP:00053909.3CCND1, CHKB, LGALS3, TP63
7MP:00107719.3CCND1, S100B, CTNNB1, MYH11, MYB
8MP:00053919.0VIM, NTRK3, NFIB, MUC1
9MP:00053768.7CHKB, NFIB, MYH11, ACTC1, ESR1
10MP:00020068.5CCND1, CTNNB1, MUC1, KIT, ESR1, TP63
11MP:00036318.5CHKB, NTRK3, NFIB, KIT, LGALS3
12MP:00030128.2CTNNB1, NTRK3, MYB, MUC1, PCNA, KIT
13MP:00053818.2CCND1, CTNNB1, MYH11, MUC1, KIT, LGALS3
14MP:00053887.9CCND1, CTNNB1, NTRK3, NFIB, LGALS3, ESR1
15MP:00028737.6CCND1, S100B, S100A1, CTNNB1, NTRK3, MYB
16MP:00053877.6VIM, CCND1, CTNNB1, MYB, PCNA, KIT
17MP:00053847.3VIM, CCND1, CTNNB1, MYB, PCNA, KIT
18MP:00053867.3VIM, CCND1, S100B, S100A1, CTNNB1, CHKB
19MP:00053856.9TP63, VIM, CCND1, S100A1, CTNNB1, NTRK3
20MP:00053786.2VIM, CCND1, CTNNB1, NTRK3, NFIB, MYH11
21MP:00107685.9MYH11, NFIB, NTRK3, CTNNB1, CCND1, VIM

Publications for Polymorphous Low-Grade Adenocarcinoma

Sources:
51PubMed
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Articles related to Polymorphous Low-Grade Adenocarcinoma:

idTitleAuthorsYear
1
Polymorphous low grade adenocarcinoma: literature review and report of lower lip lesion with suspected lung metastasis. (22379323)
2011

Genetic Variations for Polymorphous Low-Grade Adenocarcinoma

Expression for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 52QIAGEN
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Compounds for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7CHKB
2butyrate4510.6MYB
3estradiol45 11 2412.1MYB, CHKB, VIM
4cycloheximide4510.0NTRK3
5orcein459.9VIM, ACTC1, S100B
6s 100459.9S100B, MUC1, ACTC1, VIM
7serine459.7MYH11, S100B, CCND1
8creatinine459.6CHKB, ACTC1, CEACAM3
9eosin459.6MUC1, PCNA, VIM, S100B
102-methoxyethanol459.5S100A1, ACTC1, TP63, VIM
11glycogen45 2410.4CCND1, CTNNB1, CHKB, ACTC1, KIT
12dexamethasone45 50 29 1112.4CTNNB1, MYB, PCNA, S100B
13reticulin459.3PCNA, MUC1, S100B, VIM, ACTC1
14paclitaxel45 50 1111.3ESR1, CTNNB1, S100B, CCND1
15glutamine459.3CHKB, PCNA, CTNNB1, LGALS3, MYB
16dihydrotestosterone45 29 11 2412.2VIM, ESR1, CHKB
17trastuzumab45 50 1111.0CTNNB1, CCND1, MUC1, ESR1, KIT
184-hydroxytamoxifen459.0VIM, CCND1, S100B, CTNNB1, ESR1
19gefitinib45 50 1111.0ESR1, KIT, CTNNB1, CCND1, VIM
20agar459.0CHKB, LGALS3, MUC1, VIM, CTNNB1, CCND1
21roscovitine458.9CCND1, VIM, CTNNB1, PCNA
22imatinib45 50 1110.8CCND1, S100B, CTNNB1, MYB, KIT, ACTC1
23biotin45 11 2410.7ACTC1, VIM, CTNNB1, MUC1, PCNA, S100A1
24adriamycin458.6CEACAM3, MUC1, VIM, CTNNB1, CCND1
25steroid458.5MYB, SERPINB5, ESR1, CCND1, CHKB, CEACAM3
26bromodeoxyuridine458.5VIM, PCNA, MYB, CTNNB1, S100B, TP63
27formaldehyde45 249.5VIM, CCND1, S100B, MUC1, PCNA, ACTC1
28mucicarmine458.4TP63, VIM, S100B, S100A1, MUC1, ACTC1
29cisplatin45 50 60 1111.4CTNNB1, MUC1, PCNA, SERPINB5, TP63, LGALS3
30lactate458.4PCNA, CEACAM3, LGALS3, VIM, KIT, S100B
31arginine458.3MYB, VIM, CTNNB1, TP63, PCNA, CHKB
32matrigel458.3NTRK3, CCND1, MUC1, CTNNB1, LGALS3, SERPINB5
33threonine458.3NTRK3, S100B, CTNNB1, MYB, MUC1, KIT
345fluorouracil458.3CEACAM3, ESR1, PCNA, MUC1, KIT, CTNNB1
35nitric oxide45 11 2410.0KIT, LGALS3, CHKB, MUC1, MYH11, CEACAM3
36aspartate458.0CHKB, NTRK3, PCNA, CEACAM3, S100B, CTNNB1
37doxorubicin45 50 119.9TP63, CEACAM3, ESR1, KIT, MYB, CTNNB1
38b 723457.9VIM, S100B, S100A1, MUC1, PCNA, ACTC1
39methotrexate45 50 119.8CEACAM3, ESR1, KIT, PCNA, MUC1, CHKB
40alanine457.8S100B, CTNNB1, MYB, VIM, PCNA, LGALS3
41cysteine457.7CTNNB1, S100A1, MYB, VIM, MUC1, LGALS3
42tamoxifen45 50 29 1110.5MUC1, CCND1, VIM, PCNA, CHKB, CTNNB1
43thymidine45 248.4CHKB, CTNNB1, MYB, KIT, PCNA, MUC1
44hematoxylin457.2PCNA, KIT, ACTC1, LGALS3, CEACAM3, TP63
45tyrosine456.9NTRK3, CCND1, S100A1, S100B, MYB, MUC1
46testosterone45 60 11 249.8S100B, CTNNB1, CHKB, NTRK3, MUC1, PCNA
47retinoic acid45 247.0LGALS3, ACTC1, KIT, PCNA, MUC1, MYB
48progesterone45 60 29 11 249.5CEACAM3, ESR1, SERPINB5, LGALS3, ACTC1, KIT
49paraffin455.5CHKB, CTNNB1, VIM, CCND1, S100B, S100A1
50vegf455.4TP63, CEACAM3, CTNNB1, S100B, CCND1, VIM

GO Terms for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

Sources:
16Gene Ontology
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Cellular components related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.0TP63, S100B, CTNNB1, CHKB, NTRK3, MUC1

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9TP63, MUC1
2positive regulation of phospholipase C activityGO:0108639.8ESR1, KIT
3epithelial cell developmentGO:0020649.8TP63, ESR1
4response to ethanolGO:0454719.5ACTC1, NTRK3, CCND1
5mitotic G1 DNA damage checkpointGO:0315719.4TP63, CCND1
6negative regulation of transcription from RNA polymerase II promoterGO:0001228.1S100A1, CTNNB1, NFIB, MYB, TP63

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.7S100A1, S100B
2p53 bindingGO:0020399.2TP63, MUC1, NTRK3
3identical protein bindingGO:0428028.1TP63, ESR1, PCNA, S100A1, S100B, VIM
4protein bindingGO:0055155.8MYH11, CTNNB1, S100A1, S100B, CCND1, VIM

Products for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Sources for Polymorphous Low-Grade Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet