MCID: PLY040
MIFTS: 37

Polymorphous Low-Grade Adenocarcinoma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

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Aliases & Descriptions for Polymorphous Low-Grade Adenocarcinoma:

Name: Polymorphous Low-Grade Adenocarcinoma 48
 
Polymorphous Low Grade Adenocarcinoma 68

Classifications:



Summaries for Polymorphous Low-Grade Adenocarcinoma

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Wikipedia:71 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

MalaCards based summary: Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to adenocarcinoma and xq12-q13.3 duplication syndrome. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways are Advanced glycosylation endproduct receptor signaling and C-MYB transcription factor network. Affiliated tissues include salivary gland, tongue and lung, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and muscle.

Related Diseases for Polymorphous Low-Grade Adenocarcinoma

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Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma10.9
2xq12-q13.3 duplication syndrome10.8ACTC1, KIT
3lymphangiomatosis10.7ACTC1, VIM
4myxoid liposarcoma of the ovary10.7ACTC1, VIM
5distal monosomy 7q3610.7MUC1, VIM
6iridogoniodysgenesis and skeletal anomalies10.7ACTC1, VIM
7transitional meningioma10.7MUC1, VIM
8pemphigus vulgaris, familial10.6CEACAM3, MUC1
9skin lipoma10.6ACTC1, VIM
10ovarian cyst10.6KIT, MUC1
11logopenic progressive aphasia10.6MUC1, S100B
12intermediate dend syndrome10.6MUC1, S100B
13monophasic synovial sarcoma10.6MUC1, VIM
14lyme disease - neurological complications10.6MUC1, S100B
15hypotonia10.6S100B, VIM
16mushroom workers' lung10.6ACTC1, S100B
17skin sarcoma10.6ACTC1, MUC1, VIM
18chronic end-stage hepatitis c10.6KIT, VIM
192q33.1 microdeletion syndrome10.5MUC1, S100A1, VIM
20mollaret meningitis10.5ACTC1, VIM
21exstrophy-epispadias complex10.5S100B, VIM
22ovarian cystadenocarcinoma10.5ACTC1, MUC1, VIM
23absence of fingerprints congenital milia10.5S100B, VIM
24pituitary deficiency due to rathke's pouch cysts10.5MUC1, S100B
25diffuse pulmonary fibrosis10.5ACTC1, S100B
26paranasal sinus cancer, adult10.5ACTC1, CEACAM3, VIM
27intravascular fasciitis10.5ACTC1, MUC1, S100A1
28congenital structural myopathy10.5MUC1, VIM
29staphyloenterotoxemia10.5ACTC1, MUC1, VIM
30hing torack dowston syndrome10.5CEACAM3, MKI67, MUC1
31benign mesenchymoma10.5MUC1, TP63, VIM
32aml with myelodysplasia-related features10.5KIT, MYH11
33vulvar alveolar soft part sarcoma10.5ACTC1, TP63, VIM
34placental site trophoblastic tumor10.5ACTC1, MKI67, MUC1
35subacute leukemia10.5MUC1, S100B
36fraxf syndrome10.5S100B, VIM
37sarcomatoid renal cell carcinoma10.5KIT, S100A1
38pseudoglandular variant testicular seminoma10.5MUC1, S100B
39extracranial neuroblastoma10.5MKI67, MUC1, VIM
40follicular adenoma10.5MUC1, S100A1, VIM
41pineoblastoma10.5CCND1, MUC1, VIM
42amelogenesis imperfecta local hypoplastic10.5MKI67, TP63, VIM
43ovarian stromal hyperthecosis10.5MUC1, TP63
44pura syndrome10.4ACTC1, KIT, MKI67
45bickerstaff brainstem encephalitis10.4MKI67, S100B
46anaplastic oligoastrocytoma10.4MUC1, S100B, VIM
47focal chorioretinitis10.4KIT, MKI67, VIM
48pediculus humanus capitis infestation10.4MUC1, S100B, VIM
49adenoiditis10.4
50lumbar plexus neoplasm10.4MUC1, S100B, VIM

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to polymorphous low-grade adenocarcinoma

Symptoms & Phenotypes for Polymorphous Low-Grade Adenocarcinoma

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GenomeRNAi Phenotypes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-358.6CCND1, CTNNB1, MYB, NFIB, VIM

MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

41 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7ACTC1, CTNNB1, KIT, MYH11, S100A1, TP63
2MP:00053918.4CCND1, CTNNB1, KIT, NFIB, NTRK3, TP63
3MP:00107718.1CCND1, CTNNB1, KIT, LGALS3, MYB, MYH11
4MP:00053818.1CCND1, CTNNB1, KIT, LGALS3, MYH11, NFIB
5MP:00053787.2ACTC1, CCND1, CTNNB1, KIT, MYB, MYH11
6MP:00028737.2ACTC1, CCND1, CTNNB1, KIT, MKI67, MYB
7MP:00053847.2ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB
8MP:00053887.1CCND1, CTNNB1, KIT, LGALS3, MYH11, NFIB
9MP:00053856.9ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB
10MP:00053766.8ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYH11
11MP:00107686.5ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB

Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

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Drugs for Polymorphous Low-Grade Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
GemcitabineapprovedPhase 2197495058-81-460750
Synonyms:
103882-84-4
122111-03-9
2',2'-DiF-dC
2',2'-Difluoro-2'-deoxycytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-.beta.-D-2',2'-difluorocytidine
2'-Deoxy-2',2'-difluorocytidine
4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one
4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
95058-81-4
AB1004842
AC1L1TUQ
C07650
CCRIS 8984
CHEBI:175901
CHEMBL888
CID60750
Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine
D02368
DB00441
DDFC
DFDC
DFdC
DFdCyd
Folfugem
GEO
Gamcitabine
GemLip
Gemcel
 
Gemcin
Gemcitabin
Gemcitabina
Gemcitabina [INN-Spanish]
Gemcitabine
Gemcitabine (USAN/INN)
Gemcitabine HCl
Gemcitabine hydrochloride
Gemcitabine stereoisomer
Gemcitabinum
Gemcitabinum [INN-Latin]
Gemtro
Gemzar
Gemzar (hydrochloride)
HMS2089P10
HSDB 7567
Inno-D07001
LS-59139
LY 188011
LY-188011
LY188011
NCGC00168784-01
NChemBio.2007.10-comp25
NSC 613327
NSC613327
TL8005979
UNII-B76N6SBZ8R
ZINC18279854
Zefei
gemcitabine
nchembio.573-comp7
nchembio.90-comp2
2Immunosuppressive AgentsPhase 212770
3Antiviral AgentsPhase 29732
4Antimetabolites, AntineoplasticPhase 27171
5AntimetabolitesPhase 211774
6Anti-Infective AgentsPhase 221402

Interventional clinical trials:

idNameStatusNCT IDPhase
1Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During SurgeryCompletedNCT00003744Phase 2

Search NIH Clinical Center for Polymorphous Low-Grade Adenocarcinoma

Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

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Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

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MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

36
Salivary gland, Tongue, Lung, Lymph node, Trachea, Pituitary, Skin

Publications for Polymorphous Low-Grade Adenocarcinoma

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Articles related to Polymorphous Low-Grade Adenocarcinoma:

(show top 50)    (show all 171)
idTitleAuthorsYear
1
Cribriform adenocarcinoma of minor salivary gland: A mimic of polymorphous low-grade adenocarcinoma. (27721624)
2016
2
Polymorphous Low-Grade Adenocarcinoma of the Palate: A Rare Case Report. (27366306)
2016
3
Polymorphous low-grade adenocarcinoma of the epiglottis: A case report. (27123278)
2016
4
Predictors of Outcome in the Phenotypic Spectrum of Polymorphous Low-grade Adenocarcinoma (PLGA) and Cribriform Adenocarcinoma of Salivary Gland (CASG): A Retrospective Study of 69 Patients. (27454943)
2016
5
Mammaglobin and DOG-1 expression in polymorphous low-grade adenocarcinoma: an appraisal of its origin and morphology. (27591391)
2016
6
Plasmacytoid-Type Cellular Differentiation in Polymorphous Low-Grade Adenocarcinoma. (26912473)
2016
7
Polymorphous low-grade adenocarcinoma: A Danish national study. (27016011)
2016
8
Doing more with less: the challenging diagnosis of polymorphous low-grade adenocarcinoma in incisional biopsy samples. (26408830)
2015
9
Polymorphous Low-Grade Adenocarcinoma of the Oral Cavity. (26413969)
2015
10
Immunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinoma. (26671844)
2015
11
Polymorphous low-grade adenocarcinoma of the upper lip: 11 cases of an uncommon diagnosis. (25747177)
2015
12
Polymorphous low grade adenocarcinoma of lip clinically mimicking squamous cell carcinoma: An unusual presentation. (25948951)
2015
13
Polymorphous low-grade adenocarcinoma of the tongue base treated by transoral robotic surgery. (25954561)
2015
14
A case report of a pulmonary metastasis of a polymorphous low-grade adenocarcinoma. (25693921)
2015
15
Polymorphous Low Grade Adenocarcinoma of Retromolar Region - A Rare Case Report with Distinct Clinical Manifestations. (26266226)
2015
16
Polymorphous low grade adenocarcinoma. (26097312)
2015
17
Histopathological spectrum of polymorphous low-grade adenocarcinoma. (26604510)
2015
18
Polymorphous low-grade adenocarcinoma of the head and neck: A population-based study of 460 cases. (25877006)
2015
19
Case report of polymorphous low-grade adenocarcinoma in the trachea with metastasis to the right middle lobe bronchus. (26273362)
2015
20
Polymorphous low-grade adenocarcinoma. (24452888)
2014
21
Oral and maxillofacial pathology. Case of the month. Polymorphous low-grade adenocarcinoma. (25163215)
2014
22
Polymorphous Low Grade Adenocarcinoma has a Consistent p63+/p40- Immunophenotype that Helps Distinguish it from Adenoid Cystic Carcinoma and Cellular Pleomorphic Adenoma. (24969705)
2014
23
PRKD1 Mutations Characterize Salivary Gland Polymorphous Low-Grade Adenocarcinoma. (25367945)
2014
24
Polymorphous low-grade adenocarcinoma: A case series and determination of recurrence. (25229805)
2014
25
Immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands. (24910675)
2014
26
Surface Papillary Epithelial Hyperplasia (Rough Mucosa) is a Helpful Clue for Identification of Polymorphous Low-Grade Adenocarcinoma. (25322702)
2014
27
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. (25240283)
2014
28
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (24265903)
2013
29
Polymorphous low-grade adenocarcinoma of the maxillary sinus. (23714964)
2013
30
Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. (24268388)
2013
31
Polymorphous Low-Grade Adenocarcinoma (PLGA) in an 18-Year-Old Male. (24426416)
2013
32
Polymorphous low-grade adenocarcinoma--management and reconstruction with temporalis myofacial flap. (24431823)
2013
33
Polymorphous low-grade adenocarcinoma of maxillary alveolus metastasising to the abdomen: the role of immunomarkers in diagnosis. (23661663)
2013
34
Proton beam therapy and continuous intra-arterial chemotherapy for polymorphous low-grade adenocarcinoma in the hard palate. (23466803)
2013
35
Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists. (23320410)
2013
36
Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin I+vI^3 in pleomorphic adenoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma. (24237725)
2013
37
Polymorphous Low-grade Adenocarcinoma of the Head and Neck. (23428952)
2013
38
Polymorphous low-grade adenocarcinoma in the upper lip: a well-described but infrequently recognized tumor. (24021444)
2013
39
Polymorphous low-grade adenocarcinoma of the larynx: a rare case report. (23981163)
2013
40
Fine needle aspiration cytology of metastatic polymorphous low-grade adenocarcinoma of the palate in a cervical lymph node. (21883542)
2013
41
Cytomorphological features of an aggressive variant of polymorphous low-grade adenocarcinoma in adolescence with lymph node metastasis. (22144102)
2013
42
Polymorphous low-grade adenocarcinoma: a 17 patient case series. (23618791)
2013
43
Polymorphous low-grade adenocarcinoma: a case report. (22184472)
2013
44
Polymorphous low-grade adenocarcinoma located in the maxillary sinus. (23011832)
2012
45
Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. (21901247)
2012
46
Intraosseous polymorphous low-grade adenocarcinoma of mandible: A rare entity. (23162596)
2012
47
Polymorphous low-grade adenocarcinoma of the parotid gland. (21546751)
2011
48
Polymorphous low grade adenocarcinoma: case series and review of surgical management. (21288614)
2011
49
Polymorphous low grade adenocarcinoma: literature review and report of lower lip lesion with suspected lung metastasis. (22379323)
2011
50
Morphological heterogeneity of oral salivary gland carcinomas: a clinicopathologic study of 41 cases with long term follow-up emphasizing the overlapping spectrum of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (21577319)
2011

Variations for Polymorphous Low-Grade Adenocarcinoma

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Expression for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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GO Terms for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Cellular components related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00057376.3ACTC1, CCND1, CTNNB1, KIT, LGALS3, MKI67

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.7MUC1, TP63
2mitotic G1 DNA damage checkpointGO:003157110.6CCND1, TP63
3epithelial cell differentiationGO:003085510.2LGALS3, MUC1, TP63
4positive regulation of histone H3-K4 methylationGO:00515719.9CTNNB1, MYB
5regulation of T cell proliferationGO:00421299.6CTNNB1, LGALS3
6positive regulation of cell proliferationGO:00082849.4CCND1, CTNNB1, KIT, NTRK3, S100B
7positive regulation of gene expressionGO:00106289.3ACTC1, CTNNB1, KIT, NTRK3, VIM

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00020399.8MUC1, NTRK3, TP63
2double-stranded DNA bindingGO:00036909.7CTNNB1, NFIB, TP63
3S100 protein bindingGO:00445489.6S100A1, S100B

Sources for Polymorphous Low-Grade Adenocarcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet