MCID: PLY040
MIFTS: 51

Polymorphous Low-Grade Adenocarcinoma malady

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Summaries for Polymorphous Low-Grade Adenocarcinoma

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Wikipedia:65 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

MalaCards based summary: Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to cystadenocarcinoma and salivary gland adenoid cystic carcinoma. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is SERPINB5 (serpin peptidase inhibitor, clade B (ovalbumin), member 5), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Lymphocyte Signaling. The compounds s 100 and orcein have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, tongue and lung, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

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Polymorphous Low-Grade Adenocarcinoma, Aliases & Descriptions:

Name: Polymorphous Low-Grade Adenocarcinoma 42
 
Polymorphous Low Grade Adenocarcinoma 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Polymorphous Low-Grade Adenocarcinoma

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Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1cystadenocarcinoma31.1CEACAM3, MUC1
2salivary gland adenoid cystic carcinoma31.0NFIB, MYB
3myoepithelioma30.4S100B, S100A1, ACTC1, VIM, SERPINB5, TP63
4pleomorphic adenoma30.2S100B, S100A1, PCNA, ACTC1, MUC1, MYH11
5adenoma30.0CTNNB1, S100A1, PCNA, ACTC1, CCND1, LGALS3
6adenocarcinoma29.6CTNNB1, PCNA, ACTC1, NTRK3, CCND1, LGALS3
7adenoiditis10.9
8nephrogenic adenoma10.6S100A1
9pericardial effusion10.6CHKB
10multicystic dysplastic kidney10.6LGALS3
11histiocytosis10.6S100B
12hidradenoma10.5MUC1
13carney triad10.5KIT
14juvenile xanthogranuloma10.5S100B
15cholesteatoma10.5S100A1, LGALS3
16langerhans-cell histiocytosis10.5S100B, S100A1
17rosai-dorfman disease10.5S100B
18epithelioid leiomyosarcoma10.4ACTC1, VIM
19fibrous meningioma10.4S100B, MUC1
20clear cell ependymoma10.4MUC1, VIM
21anaplastic ependymoma10.4S100B, MUC1
22choroid plexus papilloma10.4S100B, MUC1
23mucinous cystadenocarcinoma10.4CEACAM3, MUC1
24mesenchymal chondrosarcoma10.4MUC1, VIM
25cutaneous paget's disease10.4CEACAM3, MUC1
26adenomatoid tumor10.4VIM
27cutaneous fibrous histiocytoma10.4S100B, S100A1, ACTC1
28clear cell sarcoma10.4KIT, S100B
29fibroma10.4S100A1, ACTC1, VIM
30sertoli cell tumor10.4MUC1, VIM
31epithelioid sarcoma10.4MUC1, VIM
32intraductal papilloma10.4MYH11, TP63
33pulmonary alveolar proteinosis10.4CEACAM3, MUC1
34congenital mesoblastic nephroma10.4NTRK3
35granular cell tumor10.3S100B, S100A1, VIM
36secretory meningioma10.3MUC1, VIM
37paraganglioma10.3KIT, S100B, S100A1
38ectopic pregnancy10.3CHKB, MYH11
39rhabdoid tumor10.3ACTC1, MUC1, VIM
40fibrous histiocytoma10.3S100B, ACTC1, VIM
41renal clear cell carcinoma10.3S100A1, MUC1, VIM
42angiosarcoma10.3ACTC1, MUC1, VIM
43perineurioma10.3S100B, MUC1, VIM
44cholangiocarcinoma10.3LGALS3, CEACAM3, MUC1
45microphthalmia10.3KIT, S100B, ACTC1
46sex cord-gonadal stromal tumor10.3S100B, MUC1, VIM
47autoimmune thyroiditis10.3LGALS3, CHKB, TP63
48ependymoma10.3S100B, MUC1, VIM
49hemangioblastoma10.3S100B, MUC1
50carcinoid syndrome10.3ACTC1, CEACAM3, MUC1

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to polymorphous low-grade adenocarcinoma

Symptoms for Polymorphous Low-Grade Adenocarcinoma

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Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

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Drug clinical trials:

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Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

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Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

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MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

32
Salivary gland, Tongue, Lung, Lymph node, Smooth muscle, Breast, Skin, Tonsil, Pituitary

Animal Models for Polymorphous Low-Grade Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8CTNNB1, KIT, CHKB, ESR1, TP63
2MP:00020068.6TP63, ESR1, MUC1, CCND1, KIT, CTNNB1
3MP:00053678.5TP63, ESR1, MYH11, LGALS3, KIT, CTNNB1
4MP:00053908.4TP63, ESR1, CHKB, LGALS3, CCND1, KIT
5MP:00053808.4TP63, SERPINB5, ESR1, VIM, MYB, KIT
6MP:00053818.3TP63, ESR1, MYH11, MUC1, LGALS3, CCND1
7MP:00030128.2ESR1, MYB, MUC1, NTRK3, PCNA, KIT
8MP:00053798.1TP63, ESR1, MUC1, CCND1, PCNA, KIT
9MP:00053897.9TP63, ESR1, VIM, LGALS3, CCND1, PCNA
10MP:00053847.8VIM, ESR1, SERPINB5, TP63, MYB, LGALS3
11MP:00053697.8TP63, ESR1, VIM, MYH11, CHKB, ACTC1
12MP:00107717.8TP63, ESR1, MYB, MYH11, MUC1, LGALS3
13MP:00053917.7TP63, VIM, MUC1, CCND1, NTRK3, KIT
14MP:00053877.7TP63, ESR1, VIM, MYB, LGALS3, CCND1
15MP:00028737.6CCND1, MUC1, MYB, TP63, NTRK3, ACTC1
16MP:00053977.5ESR1, VIM, MYB, LGALS3, CCND1, PCNA
17MP:00053867.3TP63, ESR1, VIM, CHKB, CCND1, NTRK3
18MP:00036317.2ESR1, VIM, CHKB, LGALS3, CCND1, NTRK3
19MP:00053887.0MYH11, VIM, ESR1, TP63, LGALS3, CCND1
20MP:00053856.9CTNNB1, TP63, ESR1, VIM, MYB, MYH11
21MP:00053766.7MUC1, MYH11, VIM, ESR1, TP63, CHKB
22MP:00053786.3MYH11, MYB, VIM, ESR1, TP63, CCND1
23MP:00107685.9MYH11, MYB, VIM, ESR1, SERPINB5, TP63

Publications for Polymorphous Low-Grade Adenocarcinoma

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Articles related to Polymorphous Low-Grade Adenocarcinoma:

(show top 50)    (show all 149)
idTitleAuthorsYear
1
Immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands. (24910675)
2014
2
Polymorphous low-grade adenocarcinoma. (24452888)
2014
3
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (24265903)
2013
4
Polymorphous low-grade adenocarcinoma of the maxillary sinus. (23714964)
2013
5
Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. (24268388)
2013
6
Polymorphous Low-Grade Adenocarcinoma (PLGA) in an 18-Year-Old Male. (24426416)
2013
7
Polymorphous low-grade adenocarcinoma located in the maxillary sinus. (23011832)
2012
8
Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. (21901247)
2012
9
Polymorphous low-grade adenocarcinoma: the University of Pittsburgh experience. (20403856)
2010
10
Polymorphous low-grade adenocarcinoma of parotid gland: a rare occurrence. (19136798)
2009
11
Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (20032601)
2009
12
Polymorphous low-grade adenocarcinoma of the nasopharynx: a case report and brief review. (18820100)
2008
13
Low-grade papillary adenocarcinoma of the palate: the significance of distinguishing it from polymorphous low-grade adenocarcinoma. (20614302)
2008
14
Polymorphous low-grade adenocarcinoma of the head and neck. (18327037)
2008
15
Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. (16996782)
2007
16
Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma. (16487803)
2006
17
Retrospective study and review of polymorphous low-grade adenocarcinoma. (17146387)
2006
18
Polymorphous low-grade adenocarcinoma of the nasal fossa. (16056192)
2005
19
Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas. (15153875)
2004
20
Polymorphous low-grade adenocarcinoma of the major salivary glands: report of three cases in an unusual location. (14764060)
2004
21
Polymorphous low-grade adenocarcinoma--a rare and aggressive entity in adolescence. (15121262)
2004
22
Polymorphous low grade adenocarcinoma of the parotid gland. Cytological, histological and immunohistochemical features and review of the literature. (15168873)
2004
23
Polymorphous low-grade adenocarcinoma of the tongue. (15041060)
2004
24
Polymorphous low-grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma. (12207787)
2002
25
Cytogenetic similarities between two types of salivary gland carcinomas: adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (11463451)
2001
26
Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: distinct architectural composition revealed by collagen IV, laminin and their integrin ligands (alpha2beta1 and alpha3beta1). (10931234)
2000
27
Polymorphous low grade adenocarcinoma with distant metastases and deletions on chromosome 6q23-qter and 11q23-qter: a case report. (11265182)
2000
28
Polymorphous low-grade adenocarcinoma of the submandibular gland. (10964318)
2000
29
Histologic transformation of polymorphous low-grade adenocarcinoma of salivary gland. (10361514)
1999
30
Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases. (10421256)
1999
31
Characterization of the cellular component of polymorphous low-grade adenocarcinoma by immunohistochemistry and electron microscopy. (10435151)
1999
32
Polymorphous low-grade adenocarcinoma of the parotid gland. (9758181)
1998
33
Polymorphous low-grade adenocarcinoma of the parotid gland. (9825934)
1998
34
Polymorphous low-grade adenocarcinoma: flow cytometric, p53, and PCNA analysis. (9347503)
1997
35
Regional metastasis in polymorphous low grade adenocarcinoma. Report of a case. (9418148)
1997
36
Polymorphous low-grade adenocarcinoma (PLGA) of the tongue. (9102454)
1997
37
Assessment of proliferative activity using the MIB1 antibody help to distinguish polymorphous low grade adenocarcinoma from adenoid cystic carcinoma of salivary glands. (9505262)
1997
38
Polymorphous low-grade adenocarcinoma of the palate in a 16-year-old male patient. (8971451)
1996
39
Polymorphous low-grade adenocarcinoma of parotid gland. (8866071)
1996
40
Case presentation. Polymorphous low-grade adenocarcinoma: a minor salivary gland malignancy with benign clinical features. (9569846)
1996
41
Simultaneous multifocal polymorphous low-grade adenocarcinoma. Report of two cases. (7552866)
1995
42
Polymorphous low-grade adenocarcinoma arising in the nasal cavities with an associated undifferentiated carcinoma. (7483012)
1995
43
Argyrophilia in nucleolar organizer regions (AgNOR) in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of the salivary glands. (7690237)
1993
44
Polymorphous low-grade adenocarcinoma. (1607159)
1992
45
Polymorphous low-grade adenocarcinoma: a 'new' salivary gland tumour. (2008296)
1991
46
Polymorphous low-grade adenocarcinoma of the salivary glands: a clinicopathological comparison with adenoid cystic carcinoma. (1661700)
1991
47
Karyotypic variability and evolutionary characteristics of a polymorphous low grade adenocarcinoma in the parotid gland. (1913603)
1991
48
Case for diagnosis. Polymorphous low-grade adenocarcinoma of minor salivary gland origin. (3133600)
1988
49
Polymorphous low-grade adenocarcinoma of minor salivary gland. An immunohistochemical and clinicopathologic study. (2837102)
1988
50
Polymorphous low-grade adenocarcinoma of minor salivary glands. A study of 14 cases of a distinctive neoplasm. (6692293)
1984

Variations for Polymorphous Low-Grade Adenocarcinoma

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Expression for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Expression patterns in normal tissues for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Pathways for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Pathways related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0LGALS3, S100B
29.8MYB, LGALS3, KIT
3
Show member pathways
9.7ACTC1, MYH11, VIM
49.7ESR1, CCND1
59.6CCND1, LGALS3, VIM
69.6CCND1, KIT, MYB
79.4SERPINB5, PCNA, TP63
89.3SERPINB5, TP63, VIM, CCND1
99.3ESR1, CTNNB1, CCND1
109.3ESR1, CCND1, CTNNB1
119.3ESR1, CCND1, CTNNB1
129.0PCNA, MYB, CCND1, CTNNB1
13
Show member pathways
Signal transduction PTEN pathway60
9.0CCND1, KIT, CTNNB1, PCNA
14
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
8.8MYH11, NTRK3, ACTC1, CTNNB1, CCND1
158.8CTNNB1, ESR1, CCND1, PCNA
16
Show member pathways
8.7KIT, NTRK3, VIM, ESR1, CTNNB1
17
Show member pathways
7.8CCND1, ESR1, VIM, CTNNB1, KIT, NTRK3

Compounds for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Compounds related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1s 100449.9MUC1, ACTC1, S100B, VIM
2orcein449.6ACTC1, S100B, VIM
3eosin449.6S100B, PCNA, MUC1, VIM
42-methoxyethanol449.5ACTC1, VIM, S100A1, TP63
5reticulin449.4ACTC1, PCNA, VIM, S100B, MUC1
6trastuzumab44 50 1111.1ESR1, MUC1, CCND1, KIT, CTNNB1
74-hydroxytamoxifen449.1CTNNB1, S100B, CCND1, VIM, ESR1
8agar449.0CTNNB1, LGALS3, CHKB, MUC1, VIM, CCND1
9gefitinib44 50 1111.0KIT, CTNNB1, VIM, ESR1, CCND1
10imatinib44 50 1110.8CTNNB1, CCND1, NTRK3, MYB, ACTC1, S100B
11biotin44 24 1110.7CTNNB1, VIM, ACTC1, MUC1, PCNA, S100A1
12butyrate448.6MUC1, LGALS3, CCND1, PCNA, MYB, CTNNB1
13adriamycin448.6VIM, MUC1, CEACAM3, CCND1, CTNNB1
14dihydrotestosterone44 28 24 1111.6CTNNB1, VIM, ESR1, CHKB, MUC1
15formaldehyde44 249.6KIT, VIM, MUC1, CCND1, ACTC1, PCNA
16bromodeoxyuridine448.5S100B, PCNA, CCND1, MYB, VIM, TP63
17glutamine448.5VIM, CHKB, LGALS3, PCNA, S100B, KIT
18estradiol44 24 1110.5CHKB, CCND1, PCNA, ESR1, VIM, MYB
19mucicarmine448.5ACTC1, S100A1, S100B, CEACAM3, MUC1, VIM
20dexamethasone44 50 28 1111.4VIM, MUC1, S100B, ACTC1, CTNNB1, MYB
21threonine448.3NTRK3, MUC1, MYB, CTNNB1, S100B, KIT
22lactate448.3CEACAM3, CHKB, VIM, S100B, LGALS3, PCNA
23matrigel448.3SERPINB5, VIM, MUC1, LGALS3, NTRK3, CCND1
24paclitaxel44 50 1110.3ESR1, VIM, CCND1, PCNA, S100B, KIT
25creatinine448.3CHKB, PCNA, S100B, VIM, MUC1, CEACAM3
26arginine448.3LGALS3, CHKB, PCNA, MYB, S100B, CTNNB1
275fluorouracil448.3PCNA, CTNNB1, MUC1, KIT, ESR1, CEACAM3
28oligonucleotide448.3PCNA, CCND1, KIT, LGALS3, MYB, VIM
29cisplatin44 50 61 1111.2TP63, CTNNB1, SERPINB5, ESR1, MUC1, LGALS3
30cycloheximide448.2NTRK3, ESR1, VIM, CCND1, KIT, CTNNB1
31serine448.0MYH11, LGALS3, S100B, MUC1, VIM, MYB
32nitric oxide44 24 1110.0LGALS3, CHKB, CEACAM3, KIT, S100B, MYH11
33glycogen44 249.0CTNNB1, KIT, S100B, S100A1, ACTC1, VIM
34doxorubicin44 50 1110.0KIT, CTNNB1, CCND1, CEACAM3, MYB, VIM
35b 723447.9TP63, VIM, MUC1, CEACAM3, ACTC1, PCNA
36methotrexate50 44 119.9PCNA, KIT, CEACAM3, CCND1, ESR1, CHKB
37alanine447.9CEACAM3, LGALS3, VIM, CTNNB1, S100B, PCNA
38aspartate447.9CEACAM3, KIT, CTNNB1, S100B, CHKB, VIM
39cysteine447.7KIT, CTNNB1, S100A1, VIM, LGALS3, MYB
40tamoxifen44 50 28 1110.6SERPINB5, ESR1, VIM, MUC1, CHKB, CEACAM3
41thymidine44 248.5CEACAM3, CCND1, TP63, MYB, KIT, S100B
42steroid447.4CCND1, TP63, ESR1, MYB, CHKB, CEACAM3
43hematoxylin447.2S100B, S100A1, KIT, PCNA, ACTC1, LGALS3
44tyrosine446.9TP63, LGALS3, CTNNB1, S100B, MUC1, S100A1
45testosterone44 61 24 119.8CTNNB1, KIT, S100B, PCNA, ACTC1, NTRK3
46retinoic acid44 247.0VIM, ESR1, TP63, PCNA, MYB, CTNNB1
47paraffin445.6CTNNB1, KIT, S100B, S100A1, PCNA, ACTC1
48progesterone44 28 61 24 119.6ACTC1, CTNNB1, KIT, S100B, S100A1, PCNA
49vegf445.4MYH11, MUC1, CHKB, LGALS3, CCND1, NTRK3
50estrogen445.3LGALS3, MYH11, MYB, VIM, ESR1, CCND1

GO Terms for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Cellular components related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.6MUC1, LGALS3, ACTC1, PCNA, CTNNB1, VIM
2cytoplasmGO:0057377.2CTNNB1, TP63, SERPINB5, VIM, MUC1, LGALS3

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.1TP63, MUC1
2mitotic G1 DNA damage checkpointGO:03157110.0CCND1, TP63
3positive regulation of phospholipase C activityGO:01086310.0KIT, ESR1
4epithelial cell developmentGO:00206410.0ESR1, TP63
5response to X-rayGO:0101659.9CCND1, TP63
6mammary gland alveolus developmentGO:0607499.9ESR1, CCND1
7positive regulation of Notch signaling pathwayGO:0457479.8TP63, KIT
8response to corticosteroneGO:0514129.8CCND1, NTRK3
9proximal/distal pattern formationGO:0099549.8CTNNB1, TP63
10response to ethanolGO:0454719.8CCND1, NTRK3, ACTC1
11chromatin remodelingGO:0063389.7TP63, ESR1, MYB
12hindbrain developmentGO:0309029.4CTNNB1, NFIB
13G1/S transition of mitotic cell cycleGO:0000829.4PCNA, CCND1, MYB
14response to cadmium ionGO:0466869.3CTNNB1, PCNA
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.5TP63, ESR1, MYB, NFIB, CTNNB1
16negative regulation of transcription from RNA polymerase II promoterGO:0001228.2CTNNB1, NFIB, S100A1, CCND1, MYB, TP63

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.6S100A1, S100B
2p53 bindingGO:0020399.5NTRK3, MUC1, TP63
3double-stranded DNA bindingGO:0036909.0CTNNB1, NFIB, TP63
4chromatin bindingGO:0036828.8CTNNB1, MYB, ESR1, TP63
5identical protein bindingGO:0428028.2TP63, ESR1, VIM, PCNA, S100A1, S100B
6protein bindingGO:0055156.1CTNNB1, TP63, SERPINB5, ESR1, VIM, MYB

Products for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Sources for Polymorphous Low-Grade Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet