MCID: PLY040
MIFTS: 43

Polymorphous Low-Grade Adenocarcinoma malady

Rare diseases category

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

About this section

Polymorphous Low-Grade Adenocarcinoma, Aliases & Descriptions:

Name: Polymorphous Low-Grade Adenocarcinoma 41
 
Polymorphous Low Grade Adenocarcinoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Summaries for Polymorphous Low-Grade Adenocarcinoma

About this section


Wikipedia:63 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

MalaCards based summary: Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to cystadenocarcinoma and salivary gland adenoid cystic carcinoma. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is SERPINB5 (serpin peptidase inhibitor, clade B (ovalbumin), member 5), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Lymphocyte Signaling. The compounds s 100 and orcein have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, tongue and lung, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Related Diseases for Polymorphous Low-Grade Adenocarcinoma

About this section

Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1cystadenocarcinoma31.1CEACAM3, MUC1
2salivary gland adenoid cystic carcinoma31.0NFIB, MYB
3myoepithelioma30.4S100B, S100A1, ACTC1, VIM, SERPINB5, TP63
4pleomorphic adenoma30.3S100B, S100A1, PCNA, ACTC1, MUC1, MYH11
5adenoma30.0CTNNB1, S100A1, PCNA, ACTC1, CCND1, LGALS3
6adenocarcinoma29.6CTNNB1, PCNA, ACTC1, NTRK3, CCND1, LGALS3
7adenoiditis11.0
8nephrogenic adenoma10.6S100A1
9pericardial effusion10.6CHKB
10multicystic dysplastic kidney10.6LGALS3
11histiocytosis10.6S100B
12hidradenoma10.5MUC1
13carney triad10.5KIT
14juvenile xanthogranuloma10.5S100B
15cholesteatoma10.5S100A1, LGALS3
16langerhans-cell histiocytosis10.5S100B, S100A1
17rosai-dorfman disease10.5S100B
18epithelioid leiomyosarcoma10.4ACTC1, VIM
19fibrous meningioma10.4S100B, MUC1
20clear cell ependymoma10.4MUC1, VIM
21anaplastic ependymoma10.4S100B, MUC1
22choroid plexus papilloma10.4S100B, MUC1
23mucinous cystadenocarcinoma10.4CEACAM3, MUC1
24mesenchymal chondrosarcoma10.4MUC1, VIM
25paget disease, extramammary10.4CEACAM3, MUC1
26adenomatoid tumor10.4VIM
27cutaneous fibrous histiocytoma10.4S100B, S100A1, ACTC1
28glomus tumor10.4S100A1, ACTC1, VIM
29clear cell sarcoma10.4KIT, S100B
30fibroma10.4S100A1, ACTC1, VIM
31sertoli cell tumor10.4MUC1, VIM
32epithelioid sarcoma10.4MUC1, VIM
33intraductal papilloma10.3MYH11, TP63
34pulmonary alveolar proteinosis10.3CEACAM3, MUC1
35congenital mesoblastic nephroma10.3NTRK3
36granular cell tumor10.3S100B, S100A1, VIM
37secretory meningioma10.3MUC1, VIM
38paraganglioma10.3KIT, S100B, S100A1
39ectopic pregnancy10.3CHKB, MYH11
40rhabdoid tumor10.3ACTC1, MUC1, VIM
41fibrous histiocytoma10.3S100B, ACTC1, VIM
42renal clear cell carcinoma10.3S100A1, MUC1, VIM
43angiosarcoma10.3ACTC1, MUC1, VIM
44perineurioma10.3S100B, MUC1, VIM
45cholangiocarcinoma10.3LGALS3, CEACAM3, MUC1
46microphthalmia10.3KIT, S100B, ACTC1
47sex cord-gonadal stromal tumor10.3S100B, MUC1, VIM
48hashimoto thyroiditis10.3LGALS3, CHKB, TP63
49ependymoma10.3S100B, MUC1, VIM
50hemangioblastoma10.3S100B, MUC1

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to polymorphous low-grade adenocarcinoma

Symptoms for Polymorphous Low-Grade Adenocarcinoma

About this section

Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

About this section

Drug clinical trials:

Search ClinicalTrials for Polymorphous Low-Grade Adenocarcinoma

Search NIH Clinical Center for Polymorphous Low-Grade Adenocarcinoma

Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

About this section

Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

About this section

MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

31
Salivary gland, Tongue, Lung, Lymph node, Smooth muscle, Breast, Skin, Tonsil, Pituitary

Animal Models for Polymorphous Low-Grade Adenocarcinoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma:

35 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8CTNNB1, KIT, CHKB, ESR1, TP63
2MP:00020068.6TP63, ESR1, MUC1, CCND1, KIT, CTNNB1
3MP:00053678.5TP63, ESR1, MYH11, LGALS3, KIT, CTNNB1
4MP:00053908.4TP63, ESR1, CHKB, LGALS3, CCND1, KIT
5MP:00053808.4TP63, SERPINB5, ESR1, VIM, MYB, KIT
6MP:00053818.3TP63, ESR1, MYH11, MUC1, LGALS3, CCND1
7MP:00030128.2ESR1, MYB, MUC1, NTRK3, PCNA, KIT
8MP:00053798.1TP63, ESR1, MUC1, CCND1, PCNA, KIT
9MP:00053897.9TP63, ESR1, VIM, LGALS3, CCND1, PCNA
10MP:00053847.8VIM, ESR1, SERPINB5, TP63, MYB, LGALS3
11MP:00053697.8TP63, ESR1, VIM, MYH11, CHKB, ACTC1
12MP:00107717.8TP63, ESR1, MYB, MYH11, MUC1, LGALS3
13MP:00053917.7TP63, VIM, MUC1, CCND1, NTRK3, KIT
14MP:00053877.7TP63, ESR1, VIM, MYB, LGALS3, CCND1
15MP:00028737.6CCND1, MUC1, MYB, TP63, NTRK3, ACTC1
16MP:00053977.5ESR1, VIM, MYB, LGALS3, CCND1, PCNA
17MP:00053867.3TP63, ESR1, VIM, CHKB, CCND1, NTRK3
18MP:00036317.2ESR1, VIM, CHKB, LGALS3, CCND1, NTRK3
19MP:00053887.0MYH11, VIM, ESR1, TP63, LGALS3, CCND1
20MP:00053856.9CTNNB1, TP63, ESR1, VIM, MYB, MYH11
21MP:00053766.7MUC1, MYH11, VIM, ESR1, TP63, CHKB
22MP:00053786.3MYH11, MYB, VIM, ESR1, TP63, CCND1
23MP:00107685.9MYH11, MYB, VIM, ESR1, SERPINB5, TP63

Publications for Polymorphous Low-Grade Adenocarcinoma

About this section

Articles related to Polymorphous Low-Grade Adenocarcinoma:

(show top 50)    (show all 152)
idTitleAuthorsYear
1
Immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands. (24910675)
2014
2
Polymorphous low-grade adenocarcinoma. (24452888)
2014
3
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (24265903)
2013
4
Polymorphous low-grade adenocarcinoma of the maxillary sinus. (23714964)
2013
5
Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. (24268388)
2013
6
Polymorphous Low-Grade Adenocarcinoma (PLGA) in an 18-Year-Old Male. (24426416)
2013
7
Polymorphous low-grade adenocarcinoma located in the maxillary sinus. (23011832)
2012
8
Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. (21901247)
2012
9
Polymorphous low-grade adenocarcinoma: the University of Pittsburgh experience. (20403856)
2010
10
Polymorphous low-grade adenocarcinoma of parotid gland: a rare occurrence. (19136798)
2009
11
Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (20032601)
2009
12
Polymorphous low-grade adenocarcinoma of the nasopharynx: a case report and brief review. (18820100)
2008
13
Polymorphous low-grade adenocarcinoma of the head and neck. (18327037)
2008
14
Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. (16996782)
2007
15
Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma. (16487803)
2006
16
Retrospective study and review of polymorphous low-grade adenocarcinoma. (17146387)
2006
17
Polymorphous low-grade adenocarcinoma of the nasal fossa. (16056192)
2005
18
Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas. (15153875)
2004
19
Polymorphous low-grade adenocarcinoma of the major salivary glands: report of three cases in an unusual location. (14764060)
2004
20
Polymorphous low-grade adenocarcinoma--a rare and aggressive entity in adolescence. (15121262)
2004
21
Polymorphous low grade adenocarcinoma of the parotid gland. Cytological, histological and immunohistochemical features and review of the literature. (15168873)
2004
22
Polymorphous low-grade adenocarcinoma of the tongue. (15041060)
2004
23
Polymorphous low-grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma. (12207787)
2002
24
Cytogenetic similarities between two types of salivary gland carcinomas: adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (11463451)
2001
25
Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: distinct architectural composition revealed by collagen IV, laminin and their integrin ligands (alpha2beta1 and alpha3beta1). (10931234)
2000
26
Polymorphous low grade adenocarcinoma with distant metastases and deletions on chromosome 6q23-qter and 11q23-qter: a case report. (11265182)
2000
27
Polymorphous low-grade adenocarcinoma of the submandibular gland. (10964318)
2000
28
Histologic transformation of polymorphous low-grade adenocarcinoma of salivary gland. (10361514)
1999
29
Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases. (10421256)
1999
30
Characterization of the cellular component of polymorphous low-grade adenocarcinoma by immunohistochemistry and electron microscopy. (10435151)
1999
31
Polymorphous low-grade adenocarcinoma of the parotid gland. (9758181)
1998
32
Polymorphous low-grade adenocarcinoma of the parotid gland. (9825934)
1998
33
Polymorphous low-grade adenocarcinoma: flow cytometric, p53, and PCNA analysis. (9347503)
1997
34
Regional metastasis in polymorphous low grade adenocarcinoma. Report of a case. (9418148)
1997
35
Polymorphous low-grade adenocarcinoma (PLGA) of the tongue. (9102454)
1997
36
Assessment of proliferative activity using the MIB1 antibody help to distinguish polymorphous low grade adenocarcinoma from adenoid cystic carcinoma of salivary glands. (9505262)
1997
37
Polymorphous low-grade adenocarcinoma of the palate in a 16-year-old male patient. (8971451)
1996
38
Polymorphous low-grade adenocarcinoma of parotid gland. (8866071)
1996
39
Case presentation. Polymorphous low-grade adenocarcinoma: a minor salivary gland malignancy with benign clinical features. (9569846)
1996
40
Simultaneous multifocal polymorphous low-grade adenocarcinoma. Report of two cases. (7552866)
1995
41
Polymorphous low-grade adenocarcinoma arising in the nasal cavities with an associated undifferentiated carcinoma. (7483012)
1995
42
Clinical and therapeutic features of polymorphous low-grade adenocarcinoma. (8108096)
1994
43
Argyrophilia in nucleolar organizer regions (AgNOR) in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of the salivary glands. (7690237)
1993
44
Polymorphous low-grade adenocarcinoma. (1607159)
1992
45
Polymorphous low-grade adenocarcinoma: a 'new' salivary gland tumour. (2008296)
1991
46
Polymorphous low-grade adenocarcinoma of the salivary glands: a clinicopathological comparison with adenoid cystic carcinoma. (1661700)
1991
47
Karyotypic variability and evolutionary characteristics of a polymorphous low grade adenocarcinoma in the parotid gland. (1913603)
1991
48
Case for diagnosis. Polymorphous low-grade adenocarcinoma of minor salivary gland origin. (3133600)
1988
49
Polymorphous low-grade adenocarcinoma of minor salivary gland. An immunohistochemical and clinicopathologic study. (2837102)
1988
50
Polymorphous low-grade adenocarcinoma of minor salivary glands. A study of 14 cases of a distinctive neoplasm. (6692293)
1984

Variations for Polymorphous Low-Grade Adenocarcinoma

About this section

Expression for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

About this section
Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

About this section

Pathways related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0S100B, LGALS3
29.8KIT, LGALS3, MYB
3
Show member pathways
9.7ACTC1, MYH11, VIM
49.7CCND1, ESR1
59.6CCND1, LGALS3, VIM
69.6KIT, CCND1, MYB
79.4PCNA, SERPINB5, TP63
89.3TP63, SERPINB5, VIM, CCND1
99.3ESR1, CCND1, CTNNB1
109.3CTNNB1, CCND1, ESR1
119.3ESR1, CCND1, CTNNB1
129.0MYB, CCND1, PCNA, CTNNB1
13
Show member pathways
Signal transduction PTEN pathway58
9.0CCND1, PCNA, KIT, CTNNB1
14
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility58
Cytoskeleton remodeling Integrin outside in signaling58
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases58
Cell adhesion Tight junctions58
Development MAG dependent inhibition of neurite outgrowth58
8.8MYH11, CCND1, NTRK3, ACTC1, CTNNB1
158.8CTNNB1, PCNA, CCND1, ESR1
16
Show member pathways
8.7ESR1, VIM, NTRK3, KIT, CTNNB1
17
Show member pathways
7.8CTNNB1, ESR1, VIM, MYH11, MUC1, CCND1

Compounds for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

About this section

Compounds related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1s 100439.9MUC1, ACTC1, S100B, VIM
2orcein439.6ACTC1, S100B, VIM
3eosin439.6S100B, PCNA, MUC1, VIM
42-methoxyethanol439.5ACTC1, VIM, S100A1, TP63
5reticulin439.4ACTC1, PCNA, VIM, S100B, MUC1
6trastuzumab43 49 1211.1ESR1, MUC1, CCND1, KIT, CTNNB1
74-hydroxytamoxifen439.1CTNNB1, S100B, CCND1, VIM, ESR1
8agar439.0CTNNB1, LGALS3, CHKB, MUC1, VIM, CCND1
9gefitinib43 49 1211.0KIT, CTNNB1, VIM, ESR1, CCND1
10imatinib43 49 1210.8CTNNB1, CCND1, NTRK3, MYB, ACTC1, S100B
11biotin43 24 1210.7CTNNB1, VIM, ACTC1, MUC1, PCNA, S100A1
12butyrate438.6MUC1, LGALS3, CCND1, PCNA, MYB, CTNNB1
13adriamycin438.6VIM, MUC1, CEACAM3, CCND1, CTNNB1
14dihydrotestosterone43 28 24 1211.6CTNNB1, VIM, ESR1, CHKB, MUC1
15formaldehyde43 249.6KIT, VIM, MUC1, CCND1, ACTC1, PCNA
16bromodeoxyuridine438.5S100B, PCNA, CCND1, MYB, VIM, TP63
17glutamine438.5VIM, CHKB, LGALS3, PCNA, S100B, KIT
18estradiol43 24 1210.5CHKB, CCND1, PCNA, ESR1, VIM, MYB
19mucicarmine438.5ACTC1, S100A1, S100B, CEACAM3, MUC1, VIM
20dexamethasone43 49 28 1211.4VIM, MUC1, S100B, ACTC1, CTNNB1, MYB
21threonine438.3NTRK3, MUC1, MYB, CTNNB1, S100B, KIT
22lactate438.3CEACAM3, CHKB, VIM, S100B, LGALS3, PCNA
23matrigel438.3SERPINB5, VIM, MUC1, LGALS3, NTRK3, CCND1
24paclitaxel43 49 1210.3ESR1, VIM, CCND1, PCNA, S100B, KIT
25creatinine438.3CHKB, PCNA, S100B, VIM, MUC1, CEACAM3
26arginine438.3LGALS3, CHKB, PCNA, MYB, S100B, CTNNB1
275fluorouracil438.3PCNA, CTNNB1, MUC1, KIT, ESR1, CEACAM3
28oligonucleotide438.3PCNA, CCND1, KIT, LGALS3, MYB, VIM
29cisplatin43 49 59 1211.2TP63, CTNNB1, SERPINB5, ESR1, MUC1, LGALS3
30cycloheximide438.2NTRK3, ESR1, VIM, CCND1, KIT, CTNNB1
31serine438.0MYH11, LGALS3, S100B, MUC1, VIM, MYB
32nitric oxide43 24 1210.0LGALS3, CHKB, CEACAM3, KIT, S100B, MYH11
33glycogen43 249.0CTNNB1, KIT, S100B, S100A1, ACTC1, VIM
34doxorubicin43 49 1210.0KIT, CTNNB1, CCND1, CEACAM3, MYB, VIM
35b 723437.9TP63, VIM, MUC1, CEACAM3, ACTC1, PCNA
36methotrexate49 43 129.9PCNA, KIT, CEACAM3, CCND1, ESR1, CHKB
37alanine437.9CEACAM3, LGALS3, VIM, CTNNB1, S100B, PCNA
38aspartate437.9CEACAM3, KIT, CTNNB1, S100B, CHKB, VIM
39cysteine437.7KIT, CTNNB1, S100A1, VIM, LGALS3, MYB
40tamoxifen43 49 28 1210.6SERPINB5, ESR1, VIM, MUC1, CHKB, CEACAM3
41thymidine43 248.5CEACAM3, CCND1, TP63, MYB, KIT, S100B
42steroid437.4CCND1, TP63, ESR1, MYB, CHKB, CEACAM3
43hematoxylin437.2S100B, S100A1, KIT, PCNA, ACTC1, LGALS3
44tyrosine436.9TP63, LGALS3, CTNNB1, S100B, MUC1, S100A1
45testosterone43 59 24 129.8CTNNB1, KIT, S100B, PCNA, ACTC1, NTRK3
46retinoic acid43 247.0VIM, ESR1, TP63, PCNA, MYB, CTNNB1
47paraffin435.6CTNNB1, KIT, S100B, S100A1, PCNA, ACTC1
48progesterone43 28 59 24 129.6ACTC1, CTNNB1, KIT, S100B, S100A1, PCNA
49vegf435.4MYH11, MUC1, CHKB, LGALS3, CCND1, NTRK3
50estrogen435.3LGALS3, MYH11, MYB, VIM, ESR1, CCND1

GO Terms for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

About this section

Cellular components related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700628.6MUC1, LGALS3, ACTC1, PCNA, CTNNB1, VIM
2cytoplasmGO:00057377.2CTNNB1, TP63, SERPINB5, VIM, MUC1, LGALS3

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.1TP63, MUC1
2mitotic G1 DNA damage checkpointGO:003157110.0CCND1, TP63
3positive regulation of phospholipase C activityGO:001086310.0KIT, ESR1
4epithelial cell developmentGO:000206410.0ESR1, TP63
5response to X-rayGO:00101659.9CCND1, TP63
6mammary gland alveolus developmentGO:00607499.9ESR1, CCND1
7positive regulation of Notch signaling pathwayGO:00457479.8TP63, KIT
8response to corticosteroneGO:00514129.8CCND1, NTRK3
9proximal/distal pattern formationGO:00099549.8CTNNB1, TP63
10response to ethanolGO:00454719.8CCND1, NTRK3, ACTC1
11chromatin remodelingGO:00063389.7TP63, ESR1, MYB
12hindbrain developmentGO:00309029.4CTNNB1, NFIB
13G1/S transition of mitotic cell cycleGO:00000829.4PCNA, CCND1, MYB
14response to cadmium ionGO:00466869.3CTNNB1, PCNA
15positive regulation of transcription from RNA polymerase II promoterGO:00459448.5TP63, ESR1, MYB, NFIB, CTNNB1
16negative regulation of transcription from RNA polymerase II promoterGO:00001228.2CTNNB1, NFIB, S100A1, CCND1, MYB, TP63

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:00445489.6S100A1, S100B
2p53 bindingGO:00020399.5NTRK3, MUC1, TP63
3double-stranded DNA bindingGO:00036909.0CTNNB1, NFIB, TP63
4chromatin bindingGO:00036828.8CTNNB1, MYB, ESR1, TP63
5identical protein bindingGO:00428028.2TP63, ESR1, VIM, PCNA, S100A1, S100B
6protein bindingGO:00055156.1CTNNB1, TP63, SERPINB5, ESR1, VIM, MYB

Products for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Polymorphous Low-Grade Adenocarcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet