MCID: PLY040
MIFTS: 38

Polymorphous Low-Grade Adenocarcinoma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

About this section

Aliases & Descriptions for Polymorphous Low-Grade Adenocarcinoma:

Name: Polymorphous Low-Grade Adenocarcinoma 48
 
Polymorphous Low Grade Adenocarcinoma 68

Classifications:



Summaries for Polymorphous Low-Grade Adenocarcinoma

About this section
Wikipedia:71 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

MalaCards based summary: Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to adenocarcinoma and adenoiditis. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Interleukin-4 and 13 signaling. Affiliated tissues include salivary gland, tongue and lung, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and muscle.

Related Diseases for Polymorphous Low-Grade Adenocarcinoma

About this section

Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma10.9
2adenoiditis10.4
3lymphomatoid papulosis10.3ACTC1, VIM
4chest wall parachordoma10.3ACTC1, VIM
5lucey-driscoll syndrome10.3MUC1, S100B
6carbon monoxide-induced parkinsonism10.3ACTC1, KIT
7secondary pulmonary hemosiderosis10.3MUC1, S100B
8isolated anterior cervical hypertrichosis10.3ACTC1, VIM
9lymphangiosarcoma10.3ACTC1, MUC1, VIM
10coronary stenosis10.3ACTC1, MUC1, VIM
11vagina leiomyosarcoma10.3ACTC1, MUC1
12marfanoid hypermobility syndrome10.3KIT, MUC1, VIM
13skeletal-extraskeletal angiomatosis10.3CEACAM3, MKI67, MUC1
14lung benign neoplasm10.3ACTC1, MUC1, VIM
15lupus - neurological sequelae10.3S100B, VIM
16growth retardation hydrocephaly lung hypoplasia10.3ACTC1, CEACAM3, VIM
17autosomal recessive stickler syndrome10.3MUC1, S100A1, VIM
18orthostatic proteinuria10.3ACTC1, MUC1, VIM
19mucinous cystadenocarcinoma10.3ACTC1, MKI67, MUC1
20myelinoclastic diffuse sclerosis10.3MUC1, S100B
21bladder adenocarcinoma10.3MKI67, MUC1, VIM
22intracranial sinus thrombosis10.3KIT, VIM
23kidney benign neoplasm10.3CEACAM3, MUC1, VIM
24pilar sheath acanthoma10.2ACTC1, KIT, VIM
25subependymal glioma10.2MKI67, MUC1, VIM
26ovarian papillary neoplasm10.2MUC1, S100A1, VIM
27aml with myelodysplasia-related features10.2MKI67, TP63, VIM
28benign schwannoma10.2S100B, VIM
29pustulosis palmaris et plantaris10.2ACTC1, KIT, MKI67
30biliary papillomatosis10.2MUC1, S100B, VIM
31postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.2MUC1, S100B, VIM
32preretinal fibrosis10.2ACTC1, MUC1, VIM
33human granulocytic anaplasmosis10.2KIT, MUC1, VIM
34microinvasive cervical squamous cell carcinoma10.2MUC1, S100B, VIM
35subglottis verrucous carcinoma10.2MUC1, S100B, VIM
36clear cell ependymoma10.2MUC1, S100B, VIM
37behcet's syndrome arthropathy10.2MUC1, S100B, VIM
38sternum cancer10.2MUC1, S100B, VIM
39invasive mole10.2KIT, MUC1, S100B
40hyperpituitarism10.2ACTC1, S100A1, VIM
41aneurysm of sinus of valsalva10.2MUC1, S100B, VIM
42lung combined type small cell carcinoma10.2MUC1, SERPINB5, TP63
43adenoma10.2
44osteomyelitis10.2ACTC1, VIM
45gastrointestinal system cancer10.2MUC1, S100B, VIM
46dyslexia10.2ACTC1, S100B, VIM
47childhood brain germinoma10.2MUC1, S100B, VIM
48chiasmal syndrome10.2ACTC1, S100B
49congenital myasthenic syndrome10.2ACTC1, VIM
50testicular granulosa cell tumor10.2ACTC1, MUC1, TP63, VIM

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to polymorphous low-grade adenocarcinoma

Symptoms & Phenotypes for Polymorphous Low-Grade Adenocarcinoma

About this section

GenomeRNAi Phenotypes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1928.7CCND1, CTNNB1, MYB, NFIB, VIM

MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4ACTC1, CTNNB1, KIT, MYH11, S100A1, TP63
2MP:00053918.4CCND1, CTNNB1, KIT, NFIB, NTRK3, TP63
3MP:00053818.3CCND1, CTNNB1, KIT, LGALS3, MYH11, NFIB
4MP:00107717.8CCND1, CTNNB1, KIT, LGALS3, MYB, MYH11
5MP:00053767.1ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYH11
6MP:00053847.0ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB
7MP:00053886.9CCND1, CTNNB1, KIT, LGALS3, MYH11, NFIB
8MP:00028736.8ACTC1, CCND1, CTNNB1, KIT, MKI67, MYB
9MP:00053856.6ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB
10MP:00107686.5ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB

Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

About this section

Drugs for Polymorphous Low-Grade Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
GemcitabineapprovedPhase 2201895058-81-460750
Synonyms:
103882-84-4
122111-03-9
2',2'-DiF-dC
2',2'-Difluoro-2'-deoxycytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-.beta.-D-2',2'-difluorocytidine
2'-Deoxy-2',2'-difluorocytidine
4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one
4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
95058-81-4
AB1004842
AC1L1TUQ
C07650
CCRIS 8984
CHEBI:175901
CHEMBL888
CID60750
Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine
D02368
DB00441
DDFC
DFDC
DFdC
DFdCyd
Folfugem
GEO
Gamcitabine
GemLip
Gemcel
 
Gemcin
Gemcitabin
Gemcitabina
Gemcitabina [INN-Spanish]
Gemcitabine
Gemcitabine (USAN/INN)
Gemcitabine HCl
Gemcitabine hydrochloride
Gemcitabine stereoisomer
Gemcitabinum
Gemcitabinum [INN-Latin]
Gemtro
Gemzar
Gemzar (hydrochloride)
HMS2089P10
HSDB 7567
Inno-D07001
LS-59139
LY 188011
LY-188011
LY188011
NCGC00168784-01
NChemBio.2007.10-comp25
NSC 613327
NSC613327
TL8005979
UNII-B76N6SBZ8R
ZINC18279854
Zefei
gemcitabine
nchembio.573-comp7
nchembio.90-comp2
2Immunosuppressive AgentsPhase 213086
3Antiviral AgentsPhase 29967
4Antimetabolites, AntineoplasticPhase 27361
5AntimetabolitesPhase 212054
6Anti-Infective AgentsPhase 222062

Interventional clinical trials:

idNameStatusNCT IDPhase
1Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During SurgeryCompletedNCT00003744Phase 2

Search NIH Clinical Center for Polymorphous Low-Grade Adenocarcinoma

Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

About this section

Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

About this section

MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

36
Salivary gland, Tongue, Lung, Lymph node, Trachea, Pituitary, Breast

Publications for Polymorphous Low-Grade Adenocarcinoma

About this section

Articles related to Polymorphous Low-Grade Adenocarcinoma:

(show top 50)    (show all 171)
idTitleAuthorsYear
1
Mammaglobin and DOG-1 expression in polymorphous low-grade adenocarcinoma: an appraisal of its origin and morphology. (27591391)
2016
2
Polymorphous low-grade adenocarcinoma: A Danish national study. (27016011)
2016
3
Polymorphous low-grade adenocarcinoma of the epiglottis: A case report. (27123278)
2016
4
Cribriform adenocarcinoma of minor salivary gland: A mimic of polymorphous low-grade adenocarcinoma. (27721624)
2016
5
Predictors of Outcome in the Phenotypic Spectrum of Polymorphous Low-grade Adenocarcinoma (PLGA) and Cribriform Adenocarcinoma of Salivary Gland (CASG): A Retrospective Study of 69 Patients. (27454943)
2016
6
Polymorphous Low-Grade Adenocarcinoma of the Palate: A Rare Case Report. (27366306)
2016
7
Plasmacytoid-Type Cellular Differentiation in Polymorphous Low-Grade Adenocarcinoma. (26912473)
2016
8
Polymorphous Low-Grade Adenocarcinoma of the Oral Cavity. (26413969)
2015
9
Immunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinoma. (26671844)
2015
10
Polymorphous low grade adenocarcinoma of lip clinically mimicking squamous cell carcinoma: An unusual presentation. (25948951)
2015
11
Polymorphous low-grade adenocarcinoma of the upper lip: 11 cases of an uncommon diagnosis. (25747177)
2015
12
Doing more with less: the challenging diagnosis of polymorphous low-grade adenocarcinoma in incisional biopsy samples. (26408830)
2015
13
Histopathological spectrum of polymorphous low-grade adenocarcinoma. (26604510)
2015
14
A case report of a pulmonary metastasis of a polymorphous low-grade adenocarcinoma. (25693921)
2015
15
Polymorphous Low Grade Adenocarcinoma of Retromolar Region - A Rare Case Report with Distinct Clinical Manifestations. (26266226)
2015
16
Polymorphous low-grade adenocarcinoma of the tongue base treated by transoral robotic surgery. (25954561)
2015
17
Polymorphous low-grade adenocarcinoma of the head and neck: A population-based study of 460 cases. (25877006)
2015
18
Case report of polymorphous low-grade adenocarcinoma in the trachea with metastasis to the right middle lobe bronchus. (26273362)
2015
19
Polymorphous low grade adenocarcinoma. (26097312)
2015
20
Immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands. (24910675)
2014
21
PRKD1 Mutations Characterize Salivary Gland Polymorphous Low-Grade Adenocarcinoma. (25367945)
2014
22
Polymorphous Low Grade Adenocarcinoma has a Consistent p63+/p40- Immunophenotype that Helps Distinguish it from Adenoid Cystic Carcinoma and Cellular Pleomorphic Adenoma. (24969705)
2014
23
Surface Papillary Epithelial Hyperplasia (Rough Mucosa) is a Helpful Clue for Identification of Polymorphous Low-Grade Adenocarcinoma. (25322702)
2014
24
Polymorphous low-grade adenocarcinoma: A case series and determination of recurrence. (25229805)
2014
25
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. (25240283)
2014
26
Polymorphous low-grade adenocarcinoma. (24452888)
2014
27
Oral and maxillofacial pathology. Case of the month. Polymorphous low-grade adenocarcinoma. (25163215)
2014
28
Polymorphous Low-Grade Adenocarcinoma (PLGA) in an 18-Year-Old Male. (24426416)
2013
29
Cytomorphological features of an aggressive variant of polymorphous low-grade adenocarcinoma in adolescence with lymph node metastasis. (22144102)
2013
30
Polymorphous low-grade adenocarcinoma in the upper lip: a well-described but infrequently recognized tumor. (24021444)
2013
31
Polymorphous low-grade adenocarcinoma of maxillary alveolus metastasising to the abdomen: the role of immunomarkers in diagnosis. (23661663)
2013
32
Polymorphous low-grade adenocarcinoma of the larynx: a rare case report. (23981163)
2013
33
Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin I+vI^3 in pleomorphic adenoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma. (24237725)
2013
34
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (24265903)
2013
35
Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists. (23320410)
2013
36
Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. (24268388)
2013
37
Fine needle aspiration cytology of metastatic polymorphous low-grade adenocarcinoma of the palate in a cervical lymph node. (21883542)
2013
38
Polymorphous low-grade adenocarcinoma: a case report. (22184472)
2013
39
Polymorphous low-grade adenocarcinoma of the maxillary sinus. (23714964)
2013
40
Polymorphous low-grade adenocarcinoma: a 17 patient case series. (23618791)
2013
41
Polymorphous Low-grade Adenocarcinoma of the Head and Neck. (23428952)
2013
42
Proton beam therapy and continuous intra-arterial chemotherapy for polymorphous low-grade adenocarcinoma in the hard palate. (23466803)
2013
43
Polymorphous low-grade adenocarcinoma--management and reconstruction with temporalis myofacial flap. (24431823)
2013
44
Intraosseous polymorphous low-grade adenocarcinoma of mandible: A rare entity. (23162596)
2012
45
Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. (21901247)
2012
46
Polymorphous low-grade adenocarcinoma located in the maxillary sinus. (23011832)
2012
47
Polymorphous low-grade adenocarcinoma of the palate: report of a case. (22293274)
2011
48
Morphological heterogeneity of oral salivary gland carcinomas: a clinicopathologic study of 41 cases with long term follow-up emphasizing the overlapping spectrum of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (21577319)
2011
49
Polymorphous low grade adenocarcinoma: case series and review of surgical management. (21288614)
2011
50
Polymorphous low-grade adenocarcinoma of the parotid gland. (21546751)
2011

Variations for Polymorphous Low-Grade Adenocarcinoma

About this section

Expression for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

About this section
Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

About this section

GO Terms for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

About this section

Cellular components related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00057376.3ACTC1, CCND1, CTNNB1, KIT, LGALS3, MKI67

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.7MUC1, TP63
2mitotic G1 DNA damage checkpointGO:003157110.7CCND1, TP63
3epithelial cell differentiationGO:003085510.4LGALS3, MUC1, TP63
4regulation of T cell proliferationGO:004212910.3CTNNB1, LGALS3
5positive regulation of histone H3-K4 methylationGO:005157110.1CTNNB1, MYB
6response to corticosteroneGO:005141210.1CCND1, NTRK3
7cellular response to retinoic acidGO:00713009.8MUC1, MYB, NTRK3
8response to ethanolGO:00454719.4ACTC1, CCND1, NTRK3
9positive regulation of gene expressionGO:00106289.3ACTC1, CTNNB1, KIT, NTRK3, VIM
10positive regulation of cell proliferationGO:00082849.3CCND1, CTNNB1, KIT, NTRK3, S100B

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1double-stranded DNA bindingGO:000369010.1CTNNB1, NFIB, TP63
2p53 bindingGO:000203910.0MUC1, NTRK3, TP63
3S100 protein bindingGO:00445489.6S100A1, S100B
4RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009789.2CTNNB1, MUC1, MYB, NFIB

Sources for Polymorphous Low-Grade Adenocarcinoma

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet