MCID: PLY040
MIFTS: 37

Polymorphous Low-Grade Adenocarcinoma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

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Aliases & Descriptions for Polymorphous Low-Grade Adenocarcinoma:

Name: Polymorphous Low-Grade Adenocarcinoma 47
 
Polymorphous Low Grade Adenocarcinoma 67

Classifications:



Summaries for Polymorphous Low-Grade Adenocarcinoma

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Wikipedia:70 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

MalaCards based summary: Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to adenocarcinoma and xq12-q13.3 duplication syndrome. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways are Advanced glycosylation endproduct receptor signaling and C-MYB transcription factor network. Affiliated tissues include salivary gland, tongue and lung, and related mouse phenotypes are muscle and vision/eye.

Related Diseases for Polymorphous Low-Grade Adenocarcinoma

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Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma10.9
2xq12-q13.3 duplication syndrome10.8ACTC1, KIT
3lymphangiomatosis10.7ACTC1, VIM
4myxoid liposarcoma of the ovary10.7ACTC1, VIM
5distal monosomy 7q3610.7MUC1, VIM
6iridogoniodysgenesis and skeletal anomalies10.7ACTC1, VIM
7transitional meningioma10.7MUC1, VIM
8pemphigus vulgaris, familial10.6CEACAM3, MUC1
9skin lipoma10.6ACTC1, VIM
10ovarian cyst10.6KIT, MUC1
11logopenic progressive aphasia10.6MUC1, S100B
12intermediate dend syndrome10.6MUC1, S100B
13monophasic synovial sarcoma10.6MUC1, VIM
14lyme disease - neurological complications10.6MUC1, S100B
15hypotonia10.6S100B, VIM
16mushroom workers' lung10.6ACTC1, S100B
17skin sarcoma10.6ACTC1, MUC1, VIM
18chronic end-stage hepatitis c10.6KIT, VIM
192q33.1 microdeletion syndrome10.5MUC1, S100A1, VIM
20mollaret meningitis10.5ACTC1, VIM
21exstrophy-epispadias complex10.5S100B, VIM
22ovarian cystadenocarcinoma10.5ACTC1, MUC1, VIM
23absence of fingerprints congenital milia10.5S100B, VIM
24pituitary deficiency due to rathke's pouch cysts10.5MUC1, S100B
25diffuse pulmonary fibrosis10.5ACTC1, S100B
26paranasal sinus cancer, adult10.5ACTC1, CEACAM3, VIM
27intravascular fasciitis10.5ACTC1, MUC1, S100A1
28congenital structural myopathy10.5MUC1, VIM
29staphyloenterotoxemia10.5ACTC1, MUC1, VIM
30hing torack dowston syndrome10.5CEACAM3, MKI67, MUC1
31benign mesenchymoma10.5MUC1, TP63, VIM
32aml with myelodysplasia-related features10.5KIT, MYH11
33vulvar alveolar soft part sarcoma10.5ACTC1, TP63, VIM
34placental site trophoblastic tumor10.5ACTC1, MKI67, MUC1
35subacute leukemia10.5MUC1, S100B
36fraxf syndrome10.5S100B, VIM
37sarcomatoid renal cell carcinoma10.5KIT, S100A1
38pseudoglandular variant testicular seminoma10.5MUC1, S100B
39extracranial neuroblastoma10.5MKI67, MUC1, VIM
40follicular adenoma10.5MUC1, S100A1, VIM
41pineoblastoma10.5CCND1, MUC1, VIM
42amelogenesis imperfecta local hypoplastic10.5MKI67, TP63, VIM
43ovarian stromal hyperthecosis10.5MUC1, TP63
44pura syndrome10.4ACTC1, KIT, MKI67
45bickerstaff brainstem encephalitis10.4MKI67, S100B
46anaplastic oligoastrocytoma10.4MUC1, S100B, VIM
47focal chorioretinitis10.4KIT, MKI67, VIM
48pediculus humanus capitis infestation10.4MUC1, S100B, VIM
49adenoiditis10.4
50lumbar plexus neoplasm10.4MUC1, S100B, VIM

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to polymorphous low-grade adenocarcinoma

Symptoms for Polymorphous Low-Grade Adenocarcinoma

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Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

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Drugs for Polymorphous Low-Grade Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
GemcitabineapprovedPhase 2197495058-81-460750
Synonyms:
103882-84-4
122111-03-9
2',2'-DiF-dC
2',2'-Difluoro-2'-deoxycytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-.beta.-D-2',2'-difluorocytidine
2'-Deoxy-2',2'-difluorocytidine
4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one
4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
95058-81-4
AB1004842
AC1L1TUQ
C07650
CCRIS 8984
CHEBI:175901
CHEMBL888
CID60750
Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine
D02368
DB00441
DDFC
DFDC
DFdC
DFdCyd
Folfugem
GEO
Gamcitabine
GemLip
Gemcel
 
Gemcin
Gemcitabin
Gemcitabina
Gemcitabina [INN-Spanish]
Gemcitabine
Gemcitabine (USAN/INN)
Gemcitabine HCl
Gemcitabine hydrochloride
Gemcitabine stereoisomer
Gemcitabinum
Gemcitabinum [INN-Latin]
Gemtro
Gemzar
Gemzar (hydrochloride)
HMS2089P10
HSDB 7567
Inno-D07001
LS-59139
LY 188011
LY-188011
LY188011
NCGC00168784-01
NChemBio.2007.10-comp25
NSC 613327
NSC613327
TL8005979
UNII-B76N6SBZ8R
ZINC18279854
Zefei
gemcitabine
nchembio.573-comp7
nchembio.90-comp2
2Immunosuppressive AgentsPhase 212770
3Antiviral AgentsPhase 29732
4Antimetabolites, AntineoplasticPhase 27171
5AntimetabolitesPhase 211774
6Anti-Infective AgentsPhase 221402

Interventional clinical trials:

idNameStatusNCT IDPhase
1Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During SurgeryCompletedNCT00003744Phase 2

Search NIH Clinical Center for Polymorphous Low-Grade Adenocarcinoma

Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

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Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

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MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

35
Salivary gland, Tongue, Lung, Lymph node, Trachea, Pituitary, Skin

Animal Models for Polymorphous Low-Grade Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma:

40 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7ACTC1, CTNNB1, KIT, MYH11, S100A1, TP63
2MP:00053918.4CCND1, CTNNB1, KIT, NFIB, NTRK3, TP63
3MP:00107718.1CCND1, CTNNB1, KIT, LGALS3, MYB, MYH11
4MP:00053818.1CCND1, CTNNB1, KIT, LGALS3, MYH11, NFIB
5MP:00053787.2ACTC1, CCND1, CTNNB1, KIT, MYB, MYH11
6MP:00028737.2ACTC1, CCND1, CTNNB1, KIT, MKI67, MYB
7MP:00053847.2ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB
8MP:00053887.1CCND1, CTNNB1, KIT, LGALS3, MYH11, NFIB
9MP:00053856.9ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB
10MP:00053766.8ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYH11
11MP:00107686.5ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB

Publications for Polymorphous Low-Grade Adenocarcinoma

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Articles related to Polymorphous Low-Grade Adenocarcinoma:

(show top 50)    (show all 171)
idTitleAuthorsYear
1
Cribriform adenocarcinoma of minor salivary gland: A mimic of polymorphous low-grade adenocarcinoma. (27721624)
2016
2
Polymorphous Low-Grade Adenocarcinoma of the Palate: A Rare Case Report. (27366306)
2016
3
Polymorphous low-grade adenocarcinoma of the epiglottis: A case report. (27123278)
2016
4
Doing more with less: the challenging diagnosis of polymorphous low-grade adenocarcinoma in incisional biopsy samples. (26408830)
2015
5
Polymorphous Low-Grade Adenocarcinoma of the Oral Cavity. (26413969)
2015
6
Immunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinoma. (26671844)
2015
7
Polymorphous low-grade adenocarcinoma. (24452888)
2014
8
Oral and maxillofacial pathology. Case of the month. Polymorphous low-grade adenocarcinoma. (25163215)
2014
9
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (24265903)
2013
10
Polymorphous low-grade adenocarcinoma of the maxillary sinus. (23714964)
2013
11
Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. (24268388)
2013
12
Polymorphous Low-Grade Adenocarcinoma (PLGA) in an 18-Year-Old Male. (24426416)
2013
13
Polymorphous low-grade adenocarcinoma--management and reconstruction with temporalis myofacial flap. (24431823)
2013
14
Polymorphous low-grade adenocarcinoma located in the maxillary sinus. (23011832)
2012
15
Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. (21901247)
2012
16
Intraosseous polymorphous low-grade adenocarcinoma of mandible: A rare entity. (23162596)
2012
17
Polymorphous low-grade adenocarcinoma of the parotid gland. (21546751)
2011
18
Polymorphous low-grade adenocarcinoma of the nasopharynx: a case report and brief review. (18820100)
2008
19
Low-grade papillary adenocarcinoma of the palate: the significance of distinguishing it from polymorphous low-grade adenocarcinoma. (20614302)
2008
20
Polymorphous low-grade adenocarcinoma of the head and neck. (18327037)
2008
21
Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. (16996782)
2007
22
Application of alpha-smooth muscle actin and c-kit in the differential diagnosis of adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. (16807072)
2007
23
Primary polymorphous low-grade adenocarcinoma of lung treated by sleeve bronchial resection: a case report. (17449954)
2007
24
Polymorphous low grade adenocarcinoma: review and case report. (18059236)
2007
25
Retrospective study and review of polymorphous low-grade adenocarcinoma. (17146387)
2006
26
Polymorphous low-grade adenocarcinoma of the nasal fossa. (16056192)
2005
27
Polymorphous low-grade adenocarcinoma of the palate: report of cases. (15963668)
2005
28
Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas. (15153875)
2004
29
Polymorphous low-grade adenocarcinoma of the major salivary glands: report of three cases in an unusual location. (14764060)
2004
30
Polymorphous low-grade adenocarcinoma--a rare and aggressive entity in adolescence. (15121262)
2004
31
Polymorphous low grade adenocarcinoma of the parotid gland. Cytological, histological and immunohistochemical features and review of the literature. (15168873)
2004
32
Polymorphous low-grade adenocarcinoma of the tongue. (15041060)
2004
33
Polymorphous low-grade adenocarcinoma of the lacrimal gland. (15197069)
2004
34
Cytomorphology of polymorphous low grade adenocarcinoma--diagnosis and pitfalls. (15025286)
2003
35
Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: distinct architectural composition revealed by collagen IV, laminin and their integrin ligands (alpha2beta1 and alpha3beta1). (10931234)
2000
36
Polymorphous low grade adenocarcinoma with distant metastases and deletions on chromosome 6q23-qter and 11q23-qter: a case report. (11265182)
2000
37
Polymorphous low-grade adenocarcinoma of the submandibular gland. (10964318)
2000
38
Histologic transformation of polymorphous low-grade adenocarcinoma of salivary gland. (10361514)
1999
39
Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases. (10421256)
1999
40
Polymorphous low-grade adenocarcinoma of the parotid gland. (9758181)
1998
41
Polymorphous low-grade adenocarcinoma of the parotid gland. (9825934)
1998
42
Polymorphous low-grade adenocarcinoma: flow cytometric, p53, and PCNA analysis. (9347503)
1997
43
Regional metastasis in polymorphous low grade adenocarcinoma. Report of a case. (9418148)
1997
44
Polymorphous low-grade adenocarcinoma of the tongue. (8759555)
1996
45
Simultaneous multifocal polymorphous low-grade adenocarcinoma. Report of two cases. (7552866)
1995
46
Clinical and therapeutic features of polymorphous low-grade adenocarcinoma. (8108096)
1994
47
Argyrophilia in nucleolar organizer regions (AgNOR) in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of the salivary glands. (7690237)
1993
48
Polymorphous low-grade adenocarcinoma. (1607159)
1992
49
Polymorphous low-grade adenocarcinoma of the salivary glands: a clinicopathological comparison with adenoid cystic carcinoma. (1661700)
1991
50
Polymorphous low-grade adenocarcinoma of minor salivary glands. A study of 14 cases of a distinctive neoplasm. (6692293)
1984

Variations for Polymorphous Low-Grade Adenocarcinoma

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Expression for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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GO Terms for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Cellular components related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00057376.3ACTC1, CCND1, CTNNB1, KIT, LGALS3, MKI67

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.5MUC1, TP63
2mitotic G1 DNA damage checkpointGO:003157110.5CCND1, TP63
3regulation of T cell proliferationGO:004212910.0CTNNB1, LGALS3
4positive regulation of histone H3-K4 methylationGO:00515719.8CTNNB1, MYB
5epithelial cell differentiationGO:00308559.2LGALS3, MUC1, TP63
6positive regulation of gene expressionGO:00106288.8ACTC1, CTNNB1, KIT, NTRK3, VIM
7positive regulation of cell proliferationGO:00082848.8CCND1, CTNNB1, KIT, NTRK3, S100B

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:004454810.0S100A1, S100B
2p53 bindingGO:00020399.7MUC1, NTRK3, TP63
3double-stranded DNA bindingGO:00036909.2CTNNB1, NFIB, TP63

Sources for Polymorphous Low-Grade Adenocarcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet