MCID: PLY040
MIFTS: 35

Polymorphous Low-Grade Adenocarcinoma malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

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Aliases & Descriptions for Polymorphous Low-Grade Adenocarcinoma:

Name: Polymorphous Low-Grade Adenocarcinoma 45
 
Polymorphous Low Grade Adenocarcinoma 65


Classifications:



Summaries for Polymorphous Low-Grade Adenocarcinoma

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Wikipedia:68 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

MalaCards based summary: Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to adenoma and adenocarcinoma. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways are Advanced glycosylation endproduct receptor signaling and C-MYB transcription factor network. Affiliated tissues include salivary gland, tongue and lung, and related mouse phenotypes are digestive/alimentary and muscle.

Related Diseases for Polymorphous Low-Grade Adenocarcinoma

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Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.5ACTC1, MUC1, VIM
2adenocarcinoma11.3
3adenoiditis10.9
4pleomorphic adenoma10.6
5spigelian hernia-cryptorchidism syndrome10.3ACTC1, KIT
6lymphangiomatosis10.3ACTC1, VIM
7gastric signet ring cell adenocarcinoma10.3ACTC1, VIM
8pagod syndrome10.3CEACAM3, MUC1
9localized lipodystrophy10.3MUC1, S100B
10complex regional pain syndrome type 110.3MUC1, S100B
11orbit embryonal rhabdomyosarcoma10.3MUC1, VIM
12lupus - neurological sequelae10.3MUC1, S100B
13iodine antenatal infection10.3ACTC1, VIM
14anus lymphoma10.3KIT, TP63
15kidney leiomyosarcoma10.3ACTC1, VIM
16thyroid carcinoma with thyrotoxicosis10.3MUC1, VIM
17esophageal lipoma10.3ACTC1, VIM
18malignant hypertension10.3ACTC1, S100B
19absence of fingerprints congenital milia10.3MUC1, VIM
20pituitary dermoid and epidermoid cysts10.3MUC1, S100B
21signet ring basal cell carcinoma10.3ACTC1, S100B
22leg dermatosis10.3KIT, MUC1
23epithelioid cell synovial sarcoma10.3MUC1, VIM
24body skin hyperlaxity due to vitamin k-dependent coagulation factor deficiency10.3S100B, VIM
25lymphoplasmacyte-rich meningioma10.3MUC1, S100B
26bladder colonic type adenocarcinoma10.3ACTC1, VIM
27hypersomnia10.3S100B, VIM
28cervical incompetence10.3MUC1, S100B
29peripartum cardiomyopathy10.3MUC1, TP63
30benign multicystic peritoneal mesothelioma10.3ACTC1, VIM
31beemer ertbruggen syndrome10.3S100B, VIM
32vulvar nodular hidradenoma10.3MUC1, VIM
33hand dermatosis10.3ACTC1, MUC1, VIM
34thymoma10.3KIT, MUC1, TP63
35necrotizing fasciitis10.3ACTC1, MUC1, S100A1
36multilocular cystic renal cell carcinoma10.3ACTC1, MUC1, VIM
37prostate adenoid cystic carcinoma10.3ACTC1, MUC1, VIM
38malignant teratocarcinosarcoma10.3KIT, MUC1, VIM
39chromosomal disease10.3KIT, S100A1
40carney complex-trismus-pseudocamptodactyly syndrome10.3ACTC1, MUC1, VIM
41distal monosomy 9p10.2CEACAM3, MUC1, VIM
42graphite pneumoconiosis10.2ACTC1, CEACAM3, VIM
43gallbladder endocrine tumor10.2S100B, VIM
44female reproductive organ cancer10.2ACTC1, MUC1, VIM
45bladder urachal adenocarcinoma10.2KIT, MUC1, VIM
46cystadenofibroma10.2CEACAM3, MUC1, VIM
47adenocarcinoma in situ10.2
48salivary gland adenoid cystic carcinoma10.2
49myoepithelioma10.2
50nasopharyngitis10.2

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to polymorphous low-grade adenocarcinoma

Symptoms for Polymorphous Low-Grade Adenocarcinoma

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Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Polymorphous Low-Grade Adenocarcinoma

Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

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Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

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MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

33
Salivary gland, Tongue, Lung, Lymph node, Trachea, Pituitary, Breast

Animal Models for Polymorphous Low-Grade Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6CCND1, CTNNB1, KIT, LGALS3, MUC1, MYH11
2MP:00053698.5ACTC1, CTNNB1, KIT, MYH11, S100A1, TP63
3MP:00053918.0CCND1, CTNNB1, KIT, MUC1, NFIB, NTRK3
4MP:00053847.8ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB
5MP:00028737.7ACTC1, CCND1, CTNNB1, KIT, MUC1, MYB
6MP:00053787.3ACTC1, CCND1, CTNNB1, KIT, MYB, MYH11
7MP:00107717.3CCND1, CTNNB1, KIT, LGALS3, MUC1, MYB
8MP:00053887.2CCND1, CTNNB1, KIT, LGALS3, MYH11, NFIB
9MP:00053767.1ACTC1, CCND1, CTNNB1, KIT, LGALS3, MUC1
10MP:00053857.0ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB
11MP:00107686.5ACTC1, CCND1, CTNNB1, KIT, LGALS3, MYB

Publications for Polymorphous Low-Grade Adenocarcinoma

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Articles related to Polymorphous Low-Grade Adenocarcinoma:

(show top 50)    (show all 159)
idTitleAuthorsYear
1
Polymorphous low grade adenocarcinoma of lip clinically mimicking squamous cell carcinoma: An unusual presentation. (25948951)
2015
2
Doing more with less: the challenging diagnosis of polymorphous low-grade adenocarcinoma in incisional biopsy samples. (26408830)
2015
3
Polymorphous Low-Grade Adenocarcinoma of the Oral Cavity. (26413969)
2015
4
Polymorphous low-grade adenocarcinoma of the tongue base treated by transoral robotic surgery. (25954561)
2015
5
Immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands. (24910675)
2014
6
Polymorphous low-grade adenocarcinoma. (24452888)
2014
7
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (24265903)
2013
8
Polymorphous low-grade adenocarcinoma of the maxillary sinus. (23714964)
2013
9
Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. (24268388)
2013
10
Polymorphous Low-Grade Adenocarcinoma (PLGA) in an 18-Year-Old Male. (24426416)
2013
11
Polymorphous low-grade adenocarcinoma located in the maxillary sinus. (23011832)
2012
12
Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. (21901247)
2012
13
Polymorphous low-grade adenocarcinoma: the University of Pittsburgh experience. (20403856)
2010
14
Polymorphous low-grade adenocarcinoma of parotid gland: a rare occurrence. (19136798)
2009
15
Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (20032601)
2009
16
Polymorphous low-grade adenocarcinoma of the nasopharynx: a case report and brief review. (18820100)
2008
17
Low-grade papillary adenocarcinoma of the palate: the significance of distinguishing it from polymorphous low-grade adenocarcinoma. (20614302)
2008
18
Polymorphous low-grade adenocarcinoma of the head and neck. (18327037)
2008
19
Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. (16996782)
2007
20
Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma. (16487803)
2006
21
Retrospective study and review of polymorphous low-grade adenocarcinoma. (17146387)
2006
22
Polymorphous low-grade adenocarcinoma of the nasal fossa. (16056192)
2005
23
Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas. (15153875)
2004
24
Polymorphous low-grade adenocarcinoma--a rare and aggressive entity in adolescence. (15121262)
2004
25
Polymorphous low grade adenocarcinoma of the parotid gland. Cytological, histological and immunohistochemical features and review of the literature. (15168873)
2004
26
Polymorphous low-grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma. (12207787)
2002
27
Cytogenetic similarities between two types of salivary gland carcinomas: adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (11463451)
2001
28
Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: distinct architectural composition revealed by collagen IV, laminin and their integrin ligands (alpha2beta1 and alpha3beta1). (10931234)
2000
29
Polymorphous low grade adenocarcinoma with distant metastases and deletions on chromosome 6q23-qter and 11q23-qter: a case report. (11265182)
2000
30
Polymorphous low-grade adenocarcinoma of the submandibular gland. (10964318)
2000
31
Histologic transformation of polymorphous low-grade adenocarcinoma of salivary gland. (10361514)
1999
32
Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases. (10421256)
1999
33
Characterization of the cellular component of polymorphous low-grade adenocarcinoma by immunohistochemistry and electron microscopy. (10435151)
1999
34
Polymorphous low-grade adenocarcinoma of the parotid gland. (9758181)
1998
35
Polymorphous low-grade adenocarcinoma of the parotid gland. (9825934)
1998
36
Polymorphous low-grade adenocarcinoma: flow cytometric, p53, and PCNA analysis. (9347503)
1997
37
Regional metastasis in polymorphous low grade adenocarcinoma. Report of a case. (9418148)
1997
38
Polymorphous low-grade adenocarcinoma (PLGA) of the tongue. (9102454)
1997
39
Assessment of proliferative activity using the MIB1 antibody help to distinguish polymorphous low grade adenocarcinoma from adenoid cystic carcinoma of salivary glands. (9505262)
1997
40
Polymorphous low-grade adenocarcinoma of the palate in a 16-year-old male patient. (8971451)
1996
41
Polymorphous low-grade adenocarcinoma of parotid gland. (8866071)
1996
42
Simultaneous multifocal polymorphous low-grade adenocarcinoma. Report of two cases. (7552866)
1995
43
Polymorphous low-grade adenocarcinoma arising in the nasal cavities with an associated undifferentiated carcinoma. (7483012)
1995
44
Argyrophilia in nucleolar organizer regions (AgNOR) in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of the salivary glands. (7690237)
1993
45
Polymorphous low-grade adenocarcinoma. (1607159)
1992
46
Polymorphous low-grade adenocarcinoma: a 'new' salivary gland tumour. (2008296)
1991
47
Polymorphous low-grade adenocarcinoma of the salivary glands: a clinicopathological comparison with adenoid cystic carcinoma. (1661700)
1991
48
Karyotypic variability and evolutionary characteristics of a polymorphous low grade adenocarcinoma in the parotid gland. (1913603)
1991
49
Case for diagnosis. Polymorphous low-grade adenocarcinoma of minor salivary gland origin. (3133600)
1988
50
Polymorphous low-grade adenocarcinoma of minor salivary gland. An immunohistochemical and clinicopathologic study. (2837102)
1988

Variations for Polymorphous Low-Grade Adenocarcinoma

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Expression for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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GO Terms for genes affiliated with Polymorphous Low-Grade Adenocarcinoma

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Cellular components related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00057376.1ACTC1, CCND1, CTNNB1, KIT, LGALS3, MKI67

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.6MUC1, TP63
2regulation of T cell proliferationGO:004212910.0CTNNB1, LGALS3
3response to ethanolGO:00454719.8ACTC1, CCND1, NTRK3
4positive regulation of histone H3-K4 methylationGO:00515719.6CTNNB1, MYB
5mitotic G1 DNA damage checkpointGO:00315719.6CCND1, TP63
6epithelial cell differentiationGO:00308559.4LGALS3, MUC1, TP63
7positive regulation of cell proliferationGO:00082849.1CCND1, CTNNB1, KIT, NTRK3, S100B
8positive regulation of gene expressionGO:00106289.1ACTC1, CTNNB1, KIT, NTRK3, VIM
9negative regulation of transcription from RNA polymerase II promoterGO:00001227.9CCND1, CTNNB1, MYB, NFIB, S100A1, TP63

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:000203910.4MUC1, NTRK3, TP63
2S100 protein bindingGO:004454810.4S100A1, S100B
3double-stranded DNA bindingGO:00036909.7CTNNB1, NFIB, TP63
4protein bindingGO:00055154.7ACTC1, CCND1, CEACAM3, CTNNB1, KIT, LGALS3

Sources for Polymorphous Low-Grade Adenocarcinoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet