MCID: PLY040
MIFTS: 42

Polymorphous Low-Grade Adenocarcinoma

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

MalaCards integrated aliases for Polymorphous Low-Grade Adenocarcinoma:

Name: Polymorphous Low-Grade Adenocarcinoma 49
Polymorphous Low Grade Adenocarcinoma 69

Classifications:



External Ids:

UMLS 69 C1266086

Summaries for Polymorphous Low-Grade Adenocarcinoma

MalaCards based summary : Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to adenocarcinoma and cystadenocarcinoma. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are MicroRNAs in cancer and DNA Damage. The drugs Gemcitabine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, tongue and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

Related Diseases for Polymorphous Low-Grade Adenocarcinoma

Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 30.8 CCND1 CTNNB1 KIT MUC1 NTRK3
2 cystadenocarcinoma 30.4 CEACAM3 MUC1 VIM
3 papillary adenocarcinoma 30.2 MUC1 S100B VIM
4 salivary gland adenoid cystic carcinoma 30.1 CCND1 KIT MKI67
5 pleomorphic adenoma 30.0 ACTC1 MUC1 S100B SERPINB5 TP63 VIM
6 squamous cell carcinoma 29.7 CCND1 MKI67 MUC1 TP63
7 myoepithelioma 29.3 ACTC1 S100A1 S100B SERPINB5 TP63 VIM
8 lymphangiectasis 10.6 ACTC1 VIM
9 glomangiomyoma 10.6 ACTC1 VIM
10 angiolipoma 10.6 ACTC1 VIM
11 ovarian fibrothecoma 10.5 ACTC1 KIT
12 intravascular papillary endothelial hyperplasia 10.5 ACTC1 VIM
13 malignant peritoneal mesothelioma 10.5 MUC1 VIM
14 cutaneous leiomyosarcoma 10.5 ACTC1 VIM
15 spindle cell lipoma 10.5 ACTC1 VIM
16 adenoiditis 10.5
17 mast-cell sarcoma 10.5 KIT VIM
18 localized hypertrophic neuropathy 10.5 MUC1 S100B
19 sclerosing perineurioma 10.5 MUC1 S100B
20 biphasic synovial sarcoma 10.5 MUC1 VIM
21 epithelioid leiomyosarcoma 10.5 ACTC1 VIM
22 intracranial cysts 10.5 MUC1 S100B
23 parachordoma 10.5 ACTC1 MUC1 VIM
24 nodular hidradenoma 10.5 MUC1 VIM
25 hydromyelia 10.5 S100B VIM
26 adenofibroma 10.5 ACTC1 MUC1 VIM
27 clear cell meningioma 10.4 MUC1 VIM
28 bednar tumor 10.4 S100B VIM
29 cribriform carcinoma 10.4 KIT TP63
30 non-functioning pituitary adenoma 10.4 MUC1 S100B
31 granulosa cell tumor of the ovary 10.4 ACTC1 CEACAM3 VIM
32 fasciitis 10.4 ACTC1 MUC1 VIM
33 malignant mixed mullerian tumor 10.4 KIT MUC1 VIM
34 malignant giant cell tumor of soft parts 10.4 ACTC1 S100B
35 sinonasal undifferentiated carcinoma 10.4 CEACAM3 MKI67 MUC1
36 papillary tumor of the pineal region 10.4 MUC1 S100A1 VIM
37 rhabdoid cancer 10.4 ACTC1 MUC1 VIM
38 benign metastasizing leiomyoma 10.4 ACTC1 VIM
39 epithelioid malignant peripheral nerve sheath tumor 10.4 MUC1 S100B
40 malignant giant cell tumor 10.4 ACTC1 S100B
41 primary hepatic neuroendocrine carcinoma 10.4 S100B VIM
42 endometrial mucinous adenocarcinoma 10.4 MKI67 MUC1 VIM
43 smooth muscle tumor 10.4 ACTC1 KIT VIM
44 pericardial mesothelioma 10.4 MUC1 S100A1 VIM
45 angiosarcoma 10.4 KIT MUC1 VIM
46 oncocytoma 10.4 KIT MUC1 VIM
47 glomangioma 10.4 ACTC1 S100A1 VIM
48 ameloblastic carcinoma 10.4 MKI67 TP63 VIM
49 esophagus squamous cell carcinoma 10.4 CCND1 VIM
50 mixed type thymoma 10.4 KIT S100B

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to Polymorphous Low-Grade Adenocarcinoma

Symptoms & Phenotypes for Polymorphous Low-Grade Adenocarcinoma

GenomeRNAi Phenotypes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

25 (show all 39)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.98 MYB
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.98 NFIB VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.98 CTNNB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.98 CTNNB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.98 NFIB
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.98 MYB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.98 MYB
8 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.98 MYB
9 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.98 CCND1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.98 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.98 MYB
12 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.98 CCND1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.98 CCND1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.98 MYB
15 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.98 CCND1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.98 MYB
17 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.98 MYB
18 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.98 VIM
19 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.98 CCND1 NFIB CTNNB1 VIM MYB
20 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.98 VIM
21 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.98 VIM
22 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.98 CTNNB1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.98 CCND1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.98 CCND1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.98 CCND1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.98 CCND1 NFIB
27 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.98 VIM
28 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.98 VIM
29 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.98 NFIB
30 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.98 CCND1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.98 CTNNB1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.98 CTNNB1
33 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.98 VIM
34 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.98 CTNNB1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.98 CTNNB1 MYB
36 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.98 CTNNB1
37 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.98 CTNNB1
38 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.98 MYB
39 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.98 VIM

MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.24 CCND1 LGALS3 CTNNB1 MYB ACTC1 KIT
2 cellular MP:0005384 10.22 ACTC1 KIT CCND1 LGALS3 CTNNB1 MYB
3 behavior/neurological MP:0005386 10.21 KIT CCND1 LGALS3 CTNNB1 SERPINB5 TP63
4 homeostasis/metabolism MP:0005376 10.17 ACTC1 KIT CCND1 LGALS3 CTNNB1 MYH11
5 mortality/aging MP:0010768 10.15 ACTC1 KIT CCND1 LGALS3 CTNNB1 MYB
6 integument MP:0010771 10.01 KIT CCND1 LGALS3 CTNNB1 MYB MYH11
7 digestive/alimentary MP:0005381 10 KIT CCND1 LGALS3 CTNNB1 MYH11 NFIB
8 normal MP:0002873 9.9 CCND1 CTNNB1 MKI67 MYB ACTC1 KIT
9 muscle MP:0005369 9.87 ACTC1 KIT CTNNB1 MYH11 TP63 VIM
10 no phenotypic analysis MP:0003012 9.8 KIT MKI67 CTNNB1 MYB SERPINB5 TP63
11 respiratory system MP:0005388 9.65 CCND1 LGALS3 CTNNB1 KIT TP63 NFIB
12 vision/eye MP:0005391 9.17 KIT CCND1 CTNNB1 NFIB TP63 NTRK3

Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

Drugs for Polymorphous Low-Grade Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 2 95058-81-4 60750
2 Anti-Infective Agents Phase 2
3 Immunosuppressive Agents Phase 2
4 Antimetabolites Phase 2
5 Antimetabolites, Antineoplastic Phase 2
6 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery Completed NCT00003744 Phase 2 gemcitabine

Search NIH Clinical Center for Polymorphous Low-Grade Adenocarcinoma

Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

38
Salivary Gland, Tongue, Lung, Lymph Node, Trachea, Pituitary, Breast

Publications for Polymorphous Low-Grade Adenocarcinoma

Articles related to Polymorphous Low-Grade Adenocarcinoma:

(show top 50) (show all 177)
# Title Authors Year
1
Factors that may influence polymorphous low-grade adenocarcinoma growth. ( 28188441 )
2017
2
Advancing toward a molecular characterization of polymorphous low grade adenocarcinoma. ( 28939261 )
2017
3
Polymorphous Low Grade Adenocarcinoma of Hard Palate: AHistopathological Pictorial. ( 29056135 )
2017
4
Establishment of a primary culture of polymorphous low grade adenocarcinoma cells. ( 28647648 )
2017
5
Polymorphous Low Grade Adenocarcinoma of the Parotid in a Teenager. ( 28955679 )
2017
6
Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland. ( 26426580 )
2016
7
Cribriform adenocarcinoma of minor salivary gland: A mimic of polymorphous low-grade adenocarcinoma. ( 27721624 )
2016
8
Polymorphous low-grade adenocarcinoma: A Danish national study. ( 27016011 )
2016
9
Polymorphous low-grade adenocarcinoma of the epiglottis: A case report. ( 27123278 )
2016
10
Mammaglobin and DOG-1 expression in polymorphous low-grade adenocarcinoma: an appraisal of its origin and morphology. ( 27591391 )
2016
11
Plasmacytoid-Type Cellular Differentiation in Polymorphous Low-Grade Adenocarcinoma. ( 26912473 )
2016
12
Predictors of Outcome in the Phenotypic Spectrum of Polymorphous Low-grade Adenocarcinoma (PLGA) and Cribriform Adenocarcinoma of Salivary Gland (CASG): A Retrospective Study of 69 Patients. ( 27454943 )
2016
13
Polymorphous Low-Grade Adenocarcinoma of the Palate: A Rare Case Report. ( 27366306 )
2016
14
Histopathological spectrum of polymorphous low-grade adenocarcinoma. ( 26604510 )
2015
15
Polymorphous low-grade adenocarcinoma of the tongue base treated by transoral robotic surgery. ( 25954561 )
2015
16
Polymorphous low-grade adenocarcinoma of the upper lip: 11 cases of an uncommon diagnosis. ( 25747177 )
2015
17
Case report of polymorphous low-grade adenocarcinoma in the trachea with metastasis to the right middle lobe bronchus. ( 26273362 )
2015
18
Polymorphous Low Grade Adenocarcinoma of Retromolar Region - A Rare Case Report with Distinct Clinical Manifestations. ( 26266226 )
2015
19
Immunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinoma. ( 26671844 )
2015
20
Doing more with less: the challenging diagnosis of polymorphous low-grade adenocarcinoma in incisional biopsy samples. ( 26408830 )
2015
21
Polymorphous low grade adenocarcinoma of lip clinically mimicking squamous cell carcinoma: An unusual presentation. ( 25948951 )
2015
22
Polymorphous Low-Grade Adenocarcinoma of the Oral Cavity. ( 26413969 )
2015
23
A case report of a pulmonary metastasis of a polymorphous low-grade adenocarcinoma. ( 25693921 )
2015
24
Polymorphous low-grade adenocarcinoma of the head and neck: A population-based study of 460 cases. ( 25877006 )
2015
25
Polymorphous low grade adenocarcinoma. ( 26097312 )
2015
26
Oral and maxillofacial pathology. Case of the month. Polymorphous low-grade adenocarcinoma. ( 25163215 )
2014
27
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. ( 25240283 )
2014
28
Immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands. ( 24910675 )
2014
29
PRKD1 Mutations Characterize Salivary Gland Polymorphous Low-Grade Adenocarcinoma. ( 25367945 )
2014
30
Polymorphous Low Grade Adenocarcinoma has a Consistent p63+/p40- Immunophenotype that Helps Distinguish it from Adenoid Cystic Carcinoma and Cellular Pleomorphic Adenoma. ( 24969705 )
2014
31
Polymorphous low-grade adenocarcinoma. ( 24452888 )
2014
32
Surface Papillary Epithelial Hyperplasia (Rough Mucosa) is a Helpful Clue for Identification of Polymorphous Low-Grade Adenocarcinoma. ( 25322702 )
2014
33
Polymorphous low-grade adenocarcinoma: A case series and determination of recurrence. ( 25229805 )
2014
34
Polymorphous low-grade adenocarcinoma of the larynx: a rare case report. ( 23981163 )
2013
35
Cytomorphological features of an aggressive variant of polymorphous low-grade adenocarcinoma in adolescence with lymph node metastasis. ( 22144102 )
2013
36
Polymorphous low-grade adenocarcinoma in the upper lip: a well-described but infrequently recognized tumor. ( 24021444 )
2013
37
Polymorphous Low-Grade Adenocarcinoma (PLGA) in an 18-Year-Old Male. ( 24426416 )
2013
38
Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists. ( 23320410 )
2013
39
Polymorphous low-grade adenocarcinoma: a case report. ( 22184472 )
2013
40
Polymorphous low-grade adenocarcinoma--management and reconstruction with temporalis myofacial flap. ( 24431823 )
2013
41
Fine needle aspiration cytology of metastatic polymorphous low-grade adenocarcinoma of the palate in a cervical lymph node. ( 21883542 )
2013
42
Polymorphous Low-grade Adenocarcinoma of the Head and Neck. ( 23428952 )
2013
43
Proton beam therapy and continuous intra-arterial chemotherapy for polymorphous low-grade adenocarcinoma in the hard palate. ( 23466803 )
2013
44
Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. ( 24268388 )
2013
45
Polymorphous low-grade adenocarcinoma of the maxillary sinus. ( 23714964 )
2013
46
Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin I+vI^3 in pleomorphic adenoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma. ( 24237725 )
2013
47
Polymorphous low-grade adenocarcinoma of maxillary alveolus metastasising to the abdomen: the role of immunomarkers in diagnosis. ( 23661663 )
2013
48
Polymorphous low-grade adenocarcinoma: a 17 patient case series. ( 23618791 )
2013
49
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. ( 24265903 )
2013
50
Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. ( 21901247 )
2012

Variations for Polymorphous Low-Grade Adenocarcinoma

Expression for Polymorphous Low-Grade Adenocarcinoma

Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for Polymorphous Low-Grade Adenocarcinoma

GO Terms for Polymorphous Low-Grade Adenocarcinoma

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.72 CCND1 CTNNB1 KIT NTRK3 S100B
2 response to ethanol GO:0045471 9.63 ACTC1 CCND1 NTRK3
3 positive regulation of histone H3-K4 methylation GO:0051571 9.43 CTNNB1 MYB
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.4 MUC1 TP63
5 response to corticosterone GO:0051412 9.37 CCND1 NTRK3
6 mitotic G1 DNA damage checkpoint GO:0031571 9.26 CCND1 TP63
7 regulation of T cell proliferation GO:0042129 9.16 CTNNB1 LGALS3
8 positive regulation of gene expression GO:0010628 9.02 ACTC1 CTNNB1 KIT NTRK3 VIM
9 cranial skeletal system development GO:1904888 8.96 CTNNB1 TP63

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 9.33 CTNNB1 NFIB TP63
2 S100 protein binding GO:0044548 8.96 S100A1 S100B
3 p53 binding GO:0002039 8.8 MUC1 NTRK3 TP63

Sources for Polymorphous Low-Grade Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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