MCID: PLY013
MIFTS: 51

Polymyalgia Rheumatica malady

Summaries for Polymyalgia Rheumatica

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Polymyalgia rheumatica is a disorder that causes muscle pain and stiffness in your neck, shoulders, and hips. it is most common in women and almost always occurs in people over 50. the main symptom is stiffness after resting. other symptoms include fever, weakness and weight loss. in some cases, polymyalgia rheumatica develops overnight. in others, it is gradual. the cause is not known. there is no single test to diagnose polymyalgia rheumatica. your doctor will use your medical history, symptoms, and a physical exam to make the diagnosis. lab tests for inflammation may help confirm the diagnosis. polymyalgia rheumatica sometimes occurs along with giant cell arteritis, a condition that causes swelling of the arteries in your head. symptoms include headaches and blurred vision. doctors often prescribe prednisone, a steroid medicine, for both conditions. with treatment, polymyalgia rheumatica usually disappears in a day or two. without treatment, it usually goes away after a year or more. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Polymyalgia Rheumatica is related to arthritis and rheumatic disease. An important gene associated with Polymyalgia Rheumatica is IL1RN (interleukin 1 receptor antagonist), and among its related pathways are Malaria and PEDF Induced Signaling. The compounds estrogen and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, skeletal muscle and small intestine, and related mouse phenotype immune system.

Wikipedia:64 Polymyalgia rheumatica (which takes its name from the word \"polymyalgia\" which means \"pain in many... more...

Aliases & Classifications for Polymyalgia Rheumatica

Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 57SNOMED-CT, 27ICD9CM, 40NCIt, 61UMLS, 35MeSH, 25ICD10
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Related Diseases for Polymyalgia Rheumatica

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Polymyalgia Rheumatica via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 217)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.4CRP, HLA-DRB1, CCL5, HP, CXCL1, IL1RN
2rheumatic disease31.4APOH, CRP, IL1RN, IL1R1, MMP3
3vasculitis31.1IL1RAPL2, CXCL1, CRP, APOH
4synovitis31.0MMP3, IL1R1, IL1RN, CRP
5aortic aneurysm30.6CRP
6amyloidosis30.6CRP, IL1RAPL2, SERPINA3
7rheumatic fever30.5CRP
8tuberculosis30.5TLR9, HLA-DRB1, CRP, HP, IL12B, IL1RAPL2
9bronchiolitis30.3CCL5
10polymyositis30.3IL1RN
11uveitis30.3IL1R1
12adenocarcinoma30.3SERPINA3, IL1RAPL2, CCL5
13nephritis30.2APOH, IL1RN, IL1R1, IL1RAPL2
14arthropathy30.2CRP, IL1RN, IL1RAPL2, MMP3
15hepatitis c30.2MX1, IL12B, HP, HLA-DRB1
16vascular disease30.2APOH, HP, IL1RN, MMP3
17primary biliary cirrhosis30.2TLR9, HLA-DRB1, IL2RB
18ankylosing spondylitis30.2CRP, HP, IL1RN, IL1R1, IL1RAPL2, MMP3
19antiphospholipid syndrome30.2APOH
20ulcerative colitis30.2TLR9, HLA-DRB1, CRP, CXCL1, IL12B, IL1RN
21atherosclerosis30.2HP, CRP, APOH, TLR9, CCL5, CXCL1
22temporal arteritis11.1
23aortitis10.4
24spondylitis10.4
25spondyloarthropathy10.4
26acute myeloid leukemia10.3
27miliary tuberculosis10.3
28n syndrome10.3
29acute leukemia10.3
30osteoporosis10.3
31amyloidosis, secondary10.3
32gout10.2
33bronchiolitis obliterans organizing pneumonia10.2
34bronchiolitis obliterans10.2
35parathyroid carcinoma10.2
36granulomatous angiitis10.2
37posterior scleritis10.2
38cellulitis10.2
39granulomatous myositis10.2
40proliferative glomerulonephritis10.2
41polyarteritis nodosa10.2
42dissecting aortic aneurysm10.2
43chronic myeloid leukemia10.2
44septic arthritis10.2
45subacute bacterial endocarditis10.2
46boutonneuse fever10.2
47phaeohyphomycosis10.2
48thoracic aortic aneurysm10.2
49addison's disease10.2
50hepatitis a10.2

Graphical network of the top 20 diseases related to Polymyalgia Rheumatica:



Diseases related to polymyalgia rheumatica

Clinical Features for Polymyalgia Rheumatica

Drugs & Therapeutics for Polymyalgia Rheumatica

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Polymyalgia Rheumatica

Drug clinical trials:

Search ClinicalTrials for Polymyalgia Rheumatica

Search NIH Clinical Center for Polymyalgia Rheumatica

Search CenterWatch for Polymyalgia Rheumatica

Genetic Tests for Polymyalgia Rheumatica

Anatomical Context for Polymyalgia Rheumatica

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Polymyalgia Rheumatica:

33
Whole blood, Skeletal muscle, Small intestine, Colon, Kidney, Adrenal gland, Breast, Skin, Prostate, Myeloid, Monocytes, T cells, B cells, Endothelial, Pituitary

Animal Models for Polymyalgia Rheumatica or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Polymyalgia Rheumatica:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.4MMP3, TLR9, CRP, HP, IL12B, IL12A

Publications for Polymyalgia Rheumatica

Sources:
51PubMed
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Articles related to Polymyalgia Rheumatica:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Discontinuation of therapies in polymyalgia rheumatica and giant cell arteritis. (24129145)
2013
2
Concomitant jejunal sarcomatoid carcinoma and gastric GIST in patient with polymyalgia rheumatica: A case report. (23548706)
2013
3
Polymyalgia rheumatica. (23051717)
2013
4
Diagnosis and management of giant cell arteritis and polymyalgia rheumatica: challenges, controversies and practical tips. (23355687)
2013
5
L15. EULAR/ACR 2012 classification criteria for polymyalgia rheumatica. (23453212)
2013
6
Statin-associated polymyalgia rheumatica. An analysis using WHO global individual case safety database: a case/non-case approach. (22844450)
2012
7
Association between polymyalgia rheumatica and vascular disease: a systematic review. (22514197)
2012
8
Toll-like receptor 4 gene polymorphisms in polymyalgia rheumatica and elderly-onset rheumatoid arthritis. (22011399)
2011
9
Isolated vasculitis of the lower extremities in a patient with polymyalgia rheumatica and giant cell arteritis. (21586207)
2011
10
Ultrasonographic monitoring of response to therapy in polymyalgia rheumatica. (19773289)
2010
11
Epidemiology of giant cell arteritis and polymyalgia rheumatica. (19790127)
2009
12
Polymyalgia rheumatica prevalence in a population-based sample. (19714587)
2009
13
Inguinal pain with limping: Iliopectineal bursitis as first sign of polymyalgia rheumatica. (17950651)
2008
14
Repetitive 18-fluorodeoxyglucose positron emission tomography in isolated polymyalgia rheumatica: a prospective study in 35 patients. (17114803)
2007
15
Clinical outcomes, quality of life, and diagnostic uncertainty in the first year of polymyalgia rheumatica. (17530680)
2007
16
Glucocorticoids and cardiovascular and cerebrovascular events in polymyalgia rheumatica. (17330277)
2007
17
18F-Flourodeoxyglucose positron emission tomography in polymyalgia rheumatica: novel insight into complex pathogenesis but questionable use in predicting relapses. (17114802)
2007
18
Clinical characteristics of polymyalgia rheumatica in Japanese patients: evidence of synovitis and extracapsular inflammatory changes by fat suppression magnetic resonance imaging. (17929127)
2007
19
Late onset undifferentiated spondyloarthritis presenting with polymyalgia rheumatica features: description of seven cases. (17426977)
2007
20
Polymyalgia rheumatica and giant cell arteritis. (17111894)
2006
21
Polymyalgia rheumatica. Getting out of bed in the morning can be a challenge--especially for the many people who have this inflammatory condition. (17136794)
2006
22
Do steroids increase lymphoma risk? A case-control study of lymphoma risk in polymyalgia rheumatica/giant cell arteritis. (15843445)
2005
23
Calcium pyrophosphate deposition disease mimicking polymyalgia rheumatica: a prospective followup study of predictive factors for this condition in patients presenting with polymyalgia symptoms. (16342107)
2005
24
Inflammatory changes of hip synovial structures in polymyalgia rheumatica. (16095113)
2005
25
Polymyalgia rheumatica presenting as acute cholestatic hepatitis. (15854003)
2005
26
Acute-phase reactants and the risk of relapse/recurrence in polymyalgia rheumatica: a prospective followup study. (15696567)
2005
27
Relapse in a population based cohort of patients with polymyalgia rheumatica. (15630727)
2005
28
Serum amyloid A as a potent therapeutic marker in a refractory patient with polymyalgia rheumatica. (16258224)
2005
29
Crowned dens syndrome misdiagnosed as polymyalgia rheumatica, giant cell arteritis, meningitis or spondylitis: an analysis of eight cases. (15316123)
2004
30
Bone turnover in untreated polymyalgia rheumatica. (14722347)
2004
31
Prednisone plus methotrexate for polymyalgia rheumatica: a randomized, double-blind, placebo-controlled trial. (15466766)
2004
32
Chronic idiopathic neutropenia preceding polymyalgia rheumatica and acute myeloid leukemia. (15338195)
2004
33
Polymyalgia rheumatica: clinical presentation is key to diagnosis and treatment. (15242304)
2004
34
Patient compliance in rheumatoid arthritis, polymyalgia rheumatica, and gout. (12508389)
2003
35
Incidence of temporal arteritis in patients with polymyalgia rheumatica: a prospective study using colour Doppler ultrasonography of the temporal arteries. (11792879)
2002
36
Interleukin-1 cluster and tumor necrosis factor-alpha gene polymorphisms in polymyalgia rheumatica. (11138328)
2000
37
A study of the health assessment questionnaire to evaluate functional status in polymyalgia rheumatica. (10952744)
2000
38
Utilisation and costs of investigations, and accuracy of diagnosis of polymyalgia rheumatica by family physicians. (10941808)
2000
39
Bone mineral density and biochemical markers of bone metabolism in late onset rheumatoid arthritis and polymyalgia rheumatica--a prospective study on the influence of glucocorticoid therapy. (11155797)
2000
40
Polyarteritis nodosa mimicking polymyalgia rheumatica. (11206355)
1999
41
New arguments for a vasculitic nature of polymyalgia rheumatica using positron emission tomography. (10371283)
1999
42
Anticardiolipin antibodies in giant cell arteritis and polymyalgia rheumatica: a study of 40 cases. (9569078)
1998
43
An initially double-blind controlled 96 week trial of depot methylprednisolone against oral prednisolone in the treatment of polymyalgia rheumatica. (9569075)
1998
44
A reduced CD8+ lymphocyte subset distinguishes patients with polymyalgia rheumatica and temporal arteritis from patients with other diseases. (9536391)
1998
45
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Sensitivity of temporal artery biopsy varies with biopsy length and sectioning strategy. (9329326)
1997
46
Posterior scleritis and polymyalgia rheumatica. (9474326)
1997
47
HLA-DRB1 alleles in polymyalgia rheumatica, giant cell arteritis, and rheumatoid arthritis. (8147928)
1994
48
Immunopathogenesis, diagnosis, and treatment of giant cell arteritis, temporal arteritis, polymyalgia rheumatica, and Takayasu's arteritis. (8094625)
1993
49
Soluble interleukin 2 receptors in polymyalgia rheumatica/giant cell arteritis. Clinical and laboratory correlations. (1512765)
1992
50
Dapsone in temporal arteritis and polymyalgia rheumatica. (3172108)
1988

Genetic Variations for Polymyalgia Rheumatica

Expression for genes affiliated with Polymyalgia Rheumatica

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polymyalgia Rheumatica

Search GEO for disease gene expression data for Polymyalgia Rheumatica.

Pathways for genes affiliated with Polymyalgia Rheumatica

Sources:
30KEGG, 52QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 38NCBI BioSystems Database, 53R&D Systems, 54Reactome
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Pathways related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2KLRB1, TLR9
2
Hide members
10.2CXCL1, IL12A
3
Development Thrombopoetin signaling via JAK-STAT pathway
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10.2CRP, IL1RN, SERPINA3
410.1IL12A, TLR9, IL12B
5
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10.1IL12B, IL12A, TLR9
6
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10.1TLR9, IL12B, IL1R1
710.1CXCL1, HLA-DRB1, IL12B
810.1IL12A, IL12B, CXCL1
910.1IL12A, IL2RB, IL12B, HLA-DRB1
10
Hide members
10.0TLR9, HLA-DRB1, IL1R1, IL2RB
1110.0IL12B, IL12A, HLA-DRB1, TLR9
12
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10.0IL12A, CCL5, TLR9, IL12B
13
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10.0IL12B, TLR9, IL1R1, IL12A
14
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10.0CXCL1, IL12B, IL12A, IL2RB
1510.0IL12A, CXCL1, IL12B, IL1R1
16
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10.0IL1RN, IL2RB, MX1, HLA-DRB1, IL1R1
17
Hide members
9.9HLA-DRB1, IL2RB, IL1R1, IL12A, IL12B
18
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9.9IL12B, CCL5, IL1R1, IL2RB, IL12A
19
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9.8TLR9, MX1, IL2RB, IL1R1, IL1RN, HLA-DRB1
20
Hide members
9.8IL12B, IL2RB, IL1R1, IL12A, CCL5, CXCL1
21
Hide members
9.7CCL5, IL12A, TLR9, HLA-DRB1, IL2RB, MX1
22
Hide members
9.7IL2RB, IL12B, IL1R1, IL12A, CXCL1, TLR9

Compounds for genes affiliated with Polymyalgia Rheumatica

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6APOH
2endotoxin4510.6CXCL1, APOH
3cycloheximide4510.6IL2RB, MX1, IL1RAPL2
4anakinra45 1111.3IL1RAPL2, IL1R1, IL1RN, CRP
5amphotericin b4510.3IL1RN, IL1R1, IL1RAPL2, CCL5, CRP
6pentoxifylline45 1111.3IL1RN, IL1RAPL2, IL1R1, IL12B, IL2RB
7polysulfone4510.3IL2RB, IL1R1, IL1RN, CRP, IL1RAPL2
8adalimumab45 50 1112.3IL1RAPL2, IL1RN, CRP, IL1R1, MMP3
9rantes4510.3IL2RB, CXCL1, IL1R1, IL12B, IL1RAPL2
10hydroxychloroquine45 1111.3TLR9, APOH, CRP, IL1R1
11leflunomide50 45 1112.2IL1RN, IL1RAPL2, IL2RB, MMP3, IL1R1
12il 104510.2IL1RAPL2, IL1RN, IL12B, CCL5, IL2RB, IL1R1
13lipoteichoic acid4510.2IL1R1, TLR9, IL1RN, IL12B, APOH
14dexamethasone45 50 29 1113.2CXCL1, CCL5, SULT2A1, IL1RAPL2, IL1R1
15ivig4510.2IL2RB, IL1RAPL2, CRP, IL1R1, APOH, IL1RN
16prednisolone45 29 1112.2MMP3, APOH, CRP, IL1R1, IL1RAPL2, IL2RB
17neopterin4510.1CRP, HP, IL2RB, IL1RAPL2, IL1R1, IL1RN
18peptidoglycan45 2911.1IL1R1, IL1RN, TLR9, CCL5, IL12B
19etanercept45 50 1112.1IL1R1, IL1RN, MMP3, IL2RB, IL1RAPL2, APOH
20cuprophan4510.1IL1RAPL2, IL2RB, IL1RN, IL1R1
21leukotriene b445 60 2412.1CXCL1, IL2RB, IL1RAPL2, IL1R1, IL1RN, CCL5
22cyclosporin a45 29 6012.1IL1R1, HP, CCL5, IL2RB, IL1RAPL2, CXCL1
23aspirin45 50 29 2413.0IL2RB, APOH, IL1RAPL2, IL1R1, CRP, CCL5
24nacl4510.0SERPINA3, IL1R1, IL1RAPL2, MMP3, SULT2A1, CCL5
25sulfasalazine45 29 50 1113.0IL12B, MMP3, IL1RAPL2, IL1R1, IL1RN, CRP
26infliximab45 50 1112.0IL1R1, IL1RN, IL2RB, CXCL1, CRP, APOH
27methionine459.9SERPINA3, IL1RAPL2, MMP3, HP, IL2RB, IL1R1
28ribonucleic acid459.9MMP3, IL2RB, IL1RAPL2, IL1R1, IL1RN, CCL5
29polyethylene glycol459.9IL1RN, IL1RAPL2, HP, CRP, IL1R1
30acth459.9IL2RB, HP, IL1RN, IL1R1, IL1RAPL2, SULT2A1
31sb 20358045 6010.9MMP3, IL1R1, IL1RN, CCL5, CRP, IL12B
32vitamin d459.9CCL5, IL1R1, MMP3, SULT2A1, IL12B, HP
33iron45 2410.9IL1R1, IL1RAPL2, IL2RB, MMP3, SERPINA3, APOH
34fibrinogen459.9IL1RN, APOH, CRP, SERPINA3, HP, IL1RAPL2
35lactate459.9CCL5, MMP3, IL1R1, IL1RN, HP, CRP
36polyacrylamide459.8APOH, HP, IL12B, IL1RN, SULT2A1, SERPINA3
37creatinine459.8CCL5, APOH, IL1RN, CRP, IL2RB, IL1R1
38alanine459.8CCL5, HLA-DRB1, HP, IL1RN, IL1R1, IL2RB
39heparin45 29 11 2412.8SERPINA3, MMP3, APOH, HP, IL1RAPL2, IL1R1
40progesterone45 60 29 11 2413.8MMP3, APOH, IL1RN, SERPINA3, HP, CXCL1
41cholesterol45 29 11 2412.7SULT2A1, IL1RAPL2, IL1R1, MMP3, IL2RB, IL1RN
42vegf459.7IL1RN, HP, CRP, APOH, CCL5, IL1R1
43nitric oxide45 11 2411.6IL1R1, IL1RN, CCL5, IL12B, CXCL1, APOH
44lipid459.6CRP, IL1R1, SULT2A1, SERPINA3, MMP3, CCL5
45methotrexate45 50 1111.5IL1RAPL2, IL1R1, IL1RN, CRP, HLA-DRB1, APOH
46serine459.5HP, IL2RB, IL1RN, IL1R1, CXCL1, IL1RAPL2
47retinoic acid45 2410.3KRT15, MMP3, IL1R1, IL2RB, IL1RAPL2, IL1RN
48tyrosine459.2NM, MMP3, IL2RB, IL1R1, IL1RN, CXCL1
49calcium45 50 11 2412.2MMP3, IL1RAPL2, IL1R1, IL1RN, IL12B, CXCL1
50atp45 2910.1KRT15, MX1, MMP3, IL1RAPL2, IL1RN, HP

GO Terms for genes affiliated with Polymyalgia Rheumatica

Sources:
16Gene Ontology
See all sources

Cellular components related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 complexGO:04351410.0IL12A, IL12B
2extracellular regionGO:0055769.5CCL5, TLR9, CRP, HP, CXCL1, IL1R1
3extracellular spaceGO:0056159.2IL1RN, MMP3, SERPINA3, IL12B, CXCL1, HP

Biological processes related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.5IL12B, IL12A
2positive regulation of NK T cell activationGO:05113510.5IL12A, IL12B
3positive regulation of activation of JAK2 kinase activityGO:01053510.5CCL5, IL12B
4maintenance of gastrointestinal epitheliumGO:03027710.5SERPINA3, TLR9
5positive regulation of cell adhesionGO:04578510.4CCL5, IL12A, IL12B
6positive regulation of lymphocyte proliferationGO:05067110.4IL12B, IL12A
7positive regulation of T cell proliferationGO:04210210.4IL12B, CCL5, IL12A
8acute-phase responseGO:00695310.4CRP, SERPINA3, IL1RN, HP
9positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.4IL12B, IL12A
10positive regulation of natural killer cell activationGO:03281610.4IL12A, IL12B
11positive regulation of smooth muscle cell apoptotic processGO:03439310.3IL12B, IL12A
12T-helper 1 type immune responseGO:04208810.3HLA-DRB1, IL12B
13negative regulation of interleukin-17 productionGO:03270010.3IL12B, IL12A
14inflammatory responseGO:00695410.2TLR9, CRP, CXCL1, SERPINA3, CCL5
15immune responseGO:00695510.2HLA-DRB1, CXCL1, IL12A, IL1RN, IL1R1
16response to UV-BGO:01022410.2IL12B, IL12A
17positive regulation of interferon-gamma biosynthetic processGO:0450789.9TLR9, IL12B

Molecular functions related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.3IL1RN, TLR9
2interleukin-12 receptor bindingGO:00514310.2IL12A, IL12B
3interleukin-1 receptor activityGO:0049089.9IL1RAPL2, IL1R1

Products for genes affiliated with Polymyalgia Rheumatica

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polymyalgia Rheumatica

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet