Polymyalgia Rheumatica malady

MedlinePlus: Polymyalgia rheumatica causes muscle pain and stiffness in your neck, shoulders and hips. it is most common in women and almost always occurs in people over 50. the main symptom of polymyalgia rheumatica is stiffness after resting. other symptoms include fever, weakness and weight loss. in some cases, polymyalgia rheumatica develops overnight. in others, it is gradual. polymyalgia rheumatica sometimes occurs along with giant cell arteritis, a condition that causes swelling of the arteries in your head. symptoms include headaches and blurred vision. doctors often prescribe a medicine called prednisone for both conditions. polymyalgia rheumatic usually responds to treatment. without treatment, it usually goes away after a year or more. untreated, giant cell arteritis carries a small risk of blindness or stroke. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Polymyalgia Rheumatica, also known as polymyalgia rheumatica (disorder), is related to rheumatoid arthritis and temporal arteritis. An important gene associated with Polymyalgia Rheumatica is SERPINA3 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3), and among its related pathways are Graft-versus-host disease and IL-6 Pathway. The compounds n acetylcysteine and ivig have been mentioned in the context of this disorder. Affiliated tissues include skin, monocytes and t cells, and related mouse phenotypes are hematopoietic system and respiratory system.

Wikipedia: Polymyalgia rheumatica (which takes its name from the word \"polymyalgia\" which means \"pain in many...⁴⁴ more...

Aliases & Descriptions:

polymyalgia rheumatica 6 8 32 23 polymyalgia rheumatica (disorder) 6

polymyalgia rheumatica (disorder) 6 giant cell arteritis 43

Diseases related to polymyalgia rheumatica by text searches and GeneDecks gene sharing:

(show top 50)    (show all 875)

id	Related Disease	Score	Top Affiliating Genes
1	rheumatoid arthritis	35.3	IL1R1, IL1RN, HLA-DRB1, CRP
2	temporal arteritis	33.5	VWF, MX1, CCL2, IFNG, HSPG2, CALCA
3	arthritis	32.6	MMP3, IL1A, IL1B, IL6, TNF
4	ischemic optic neuropathy	31.7	VEGFA, APOH, CRP
5	cold agglutinin disease	29.7	IL6, HP, TNF, CRP
6	thyrotoxicosis	29.3	IL2, IL2RA, CALCA
7	cluster headache	29.1	IL2, IL2RA, IL2RB, ICAM1, CALCA, HP
8	thrombocytosis	27.7	VWF, VEGFA, IL1A, IL1B, IL6, F8
9	inflammatory bowel disease	26.4	SERPINA3, MMP3, IL12B, IL1B, IL1R1, IL1RAPL2
10	polymyositis	25.8	VWF, SERPINA3, VEGFA, IL1A, IL1RAPL2, IL1RN
11	headache	24.7	IL1B, IL1RAPL2, IL1RN, IL2, IL2RA, IL2RB
12	neuropathy	23.3	VWF, VEGFA, IL12B, IL1A, IL1B, IL1RN
13	hypoxia	22.5	VWF, VEGFA, MMP3, IL1A, IL1B, IL6
14	pneumonia	20.2	VEGFA, MMP3, IL1A, IL1B, IL1R1, IL1RAPL2
15	systemic onset juvenile idiopathic arthritis	13.7	SERPINA3, IL1R1, IL2RB
16	carotid artery disease	13.5	CCL2, CCL5, CRP
17	status asthmaticus	13.5	MMP3, IL1R1, IL1RN
18	posterior uveitis	13.5	IL2RA, IL2RB
19	thrombophlebitis	13.5	APOH, F8, CRP
20	epidermolysis bullosa acquisita	13.5	IL2RA, IL2RB, HLA-DRB1
21	osteoporosis, postmenopausal	13.5	IL1RAPL2, IL1RN, CALCA
22	cystic echinococcosis	13.4	IL12B, IL2RA, HLA-DRB1
23	gastric cancer risk after h. pylori infection	13.4	IL1B, IL1RN
24	localized scleroderma	13.4	IL2RA, CCL5, NM
25	cardiac tamponade	13.4	F8, HSPG2, CRP
26	protein-energy malnutrition	13.4	IL1RAPL2, HP, CRP
27	portal vein thrombosis	13.4	APOH, F8, CRP
28	extrinsic allergic alveolitis	13.4	IL2RA, IL2RB, CCL2, CCL5
29	mononeuritis	13.4	HSPG2, CRP
30	adrenocortical insufficiency	13.3	CALCA, CRH, POMC
31	cryopyrin-associated periodic syndrome	13.3	IL1R1, IL1RAPL2
32	hypoadrenalism	13.3	CALCA, CRH, POMC
33	infective endocarditis	13.3	VWF, APOH, CRP
34	idiopathic myopathy	13.3	IL1A, IL1R1, CCL2, CCL5
35	syphilis	13.3	APOH, CCR5, HLA-DRB1
36	oral lichen planus	13.3	IL1A, CCR5, CCL5, ICAM1
37	cinca syndrome	13.3	IL1B, IL1R1, IL1RAPL2
38	postpartum depression	13.3	CALCA, CRH, PRL
39	type 3 von willebrand disease	13.3	VWF, F8
40	anovulation	13.3	SULT2A1, CRH, PRL
41	bacterial meningitis	13.3	IL1B, CRP, CXCL1
42	familial cold autoinflammatory syndrome	13.3	IL1B, IL1R1, IL1RAPL2
43	t-lymphocytopenia	13.3	IL2, IL2RB, CRP
44	intracranial thrombosis	13.3	VWF, APOH, F8
45	cushing's syndrome	13.3	NR3C1, CRH, POMC
46	familial medullary thyroid carcinoma	13.2	CALCA, CRH, POMC
47	factor xii deficiency	13.2	VWF, APOH, F8
48	nodular goiter	13.2	IFNG, ICAM1, CALCA
49	isolated acth deficiency	13.2	CRH, PRL, POMC
50	membranous glomerulonephritis	13.2	CCL2, CCR5, HSPG2, HP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to polymyalgia rheumatica:

²²

MGI Mouse Phenotypes related to polymyalgia rheumatica:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.6	IL12B
2	respiratory system phenotype	MP:0005388	9.8	CRH, CALCA, IL12B, IL12A
3	endocrine/exocrine gland phenotype	MP:0005379	9.4	IL2, IL2RB, IFNG
4	nervous system phenotype	MP:0003631	9.0	POMC, PRL, CRH, NR3C1, HSPG2, VWF
5	skeleton phenotype	MP:0005390	8.9	NR3C1, CALCA, IL6, IL1R1, MMP3, VEGFA
6	integument phenotype	MP:0010771	8.9	POMC, PRL, CRH, NR3C1, CALCA, IFNG
7	growth/size phenotype	MP:0005378	8.4	NR3C1, HSPG2, IL6, IL2RB, IL2RA, IL2
8	digestive/alimentary phenotype	MP:0005381	8.2	NR3C1, HSPG2, IFNG, CCR5, CCL2, IL12B
9	liver/biliary system phenotype	MP:0005370	7.8	PRL, HSPG2, IFNG, CCR5, IL6, IL2
10	immune system phenotype	MP:0005387	6.7	VWF, POMC, PRL, CRH, NR3C1, TNF
11	reproductive system phenotype	MP:0005389	6.6	PRL, TNF, F8, IFNG, CCR5, CCL2
12	homeostasis/metabolism phenotype	MP:0005376	6.3	HSPG2, CALCA, HP, NR3C1, CRH, CRP
13	tumorigenesis	MP:0002006	5.8	IFNG, ICAM1, HP, TNF, PRL, POMC
14	mortality/aging	MP:0010768	5.7	CCL2, CCR5, IFNG, F8, HSPG2, HP
15	behavior/neurological phenotype	MP:0005386	5.5	POMC, PRL, CRH, NR3C1, TNF, CALCA
16	cellular phenotype	MP:0005384	4.8	CCL5, IFNG, ICAM1, HSPG2, HP, TNF
17	cardiovascular system phenotype	MP:0005385	4.3	ICAM1, HSPG2, CALCA, HP, TNF, NR3C1

Articles related to polymyalgia rheumatica:

(show top 50)    (show all 54)

id	Title	Authors	Year	Affiliating Genes
1	Predictors for treatment success and expression of gl ucocorticoid receptor in giant cell arteritis and polymyalgia rheumatica. (19684157)	Braun N.... Alscher M.D.	2009	NR3C1
2	Clinical, radiological, and biochemical characteristi cs in patients with diseases mimicking polymyalgia rheumatica. (19851514)	Yanai H.... Tada N.	2009	MMP3, CRP
3	Interleukin-12 gene polymorphisim in patients with gi ant cell arteritis, polymyalgia rheumatica and elderly-onset rheumatoid arthrit is. (19646340)	Alvarez-Rodriguez L.... Carrasco-MarA-n E.	2009	IL12A, IL12B
4	Elderly-onset rheumatoid arthritis distinguished fro m polymyalgia rheumatica with malignancy (19491524)	Fujii K.	2009	CRP
5	A case of cold agglutinin disease in the course of tr eatment for polymyalgia rheumatica. (19340395)	Nakamura H.... Eguchi K.	2009	HP
6	Expression of the class I interferon-related MxA protein in temporal arteries in polymyalgia rheumatica and temporal arteritis. (19177264)	Nordborg C.... Nordborg E.	2009	IFNG, MX1
7	Serum interleukin-6 receptor in polymyalgia rheumatica: a potential marker of relapse/recurrence risk. (18668607)	Pulsatelli L.... Meliconi R.	2008	NM
8	Interleukin-1RN gene polymorphisms in elderly patients with rheumatic inflammatory chronic conditions: Association of IL-1RN*2/2 Genotype with polymyalgia rheumatica. (19026700)	Alvarez-Rodriguez L.... Martinez-Taboada V.M.	2008	IL1RN
9	Polymyalgia rheumatica/arteritis temporalis and acquired factor VIII inhibitor. (18188659)	Gallant M.... Verbanck J.	2008	F8
10	Glucocorticoid effects on adrenal steroids and cytokine responsiveness in polymyalgia rheumatica and elderly onset rheumatoid arthritis. (16855158)	Sulli A.... Cutolo M.	2006	IL1R1, IL1RN
11	Polymyalgia rheumatica (17131799)	Kaposi NovA!k P.... Schmidt Z.	2006	IL6
12	Relationship between interleukin 6 promoter polymorphism at position -174, IL-6 serum levels, and the risk of relapse/recurrence in polymyalgia rheumatica. (16583473)	Boiardi L.... Salvarani C.	2006	IL6
13	Evaluation of the hypothalamic-pituitary-adrenal axis in untreated patients with polymyalgia rheumatica and healthy controls. (16766369)	Demir H.... KeleA9timur F.	2006	PRL
14	Serum amyloid A as a potent therapeutic marker in a r efractory patient with polymyalgia rheumatica. (16258224)	Shimojima Y.... Ikeda S.	2005	CRP
15	Interferon-gamma gene microsatellite polymorphisms in patients with biopsy-proven giant cell arteritis and isolated polymyalgia rheumatica. (15675129)	Gonzalez-Gay M.A.... Ollier W.E.	2004	IFNG
16	HLA-DRB1 allele distribution in polymyalgia rheumatica and giant cell arteritis: influence on clinical subgroups and prognosis. (15305244)	Martinez-Taboda V.M.... Rodriguez-Valverde V.	2004	HLA-DRB1
17	Genetic markers of disease susceptibility and severity in giant cell arteritis and polymyalgia rheumatica. (12920695)	GonzA!lez-Gay M.A.... Ollier W.E.	2003	HLA-DRB1
18	Giant-cell arteritis and polymyalgia rheumatica. (13679329)	Weyand C.M.... Goronzy J.J.	2003	IL6
19	Serum amyloid A as a useful index of disease activity in polymyalgia rheumatica (12910963)	Yamane T.... Nomura T.	2003	CRP
20	Hypothalamic-pituitary-adrenocortical axis function in patients with polymyalgia rheumatica and giant cell arteritis. (12621591)	Pacheco M.J.... Martinez-Taboada V.M.	2003	POMC
21	Treatment of refractory polymyalgia rheumatica with i nfliximab: a pilot study. (12672196)	Salvarani C.... Boiardi L.	2003	IL6, CRP
22	IL-6 promoter polymorphism at position -174 modulates the phenotypic expression of polymyalgia rheumatica in biopsy-proven giant cell arteritis. (12051396)	Gonzalez-Gay M.A.... Ollier W.E.	2002	IL6
23	In polymyalgia rheumatica serum prolactin is positively correlated with the number of typical symptoms but not with typical inflammatory markers. (11961173)	Straub R.H.... Lang B.	2002	IL2, PRL, IL1RN
24	Corticotropin releasing hormone promoter polymorphisms in giant cell arteritis and polymyalgia rheumatica. (12051390)	Gonzalez-Gay M.A.... Ollier W.E.	2002	CRH
25	Analysis of the B cell repertoire against autoantigens in patients with giant cell arteritis and polymyalgia rheumatica. (11876765)	Schmits R.... Pfreundschuh M.	2002	KRT15
26	Intercellular adhesion molecule-1 gene polymorphisms in isolated polymyalgia rheumatica. (11911111)	Amoli M.M.... Gonzalez-Gay M.A.	2002	ICAM1, HLA-DRB1
27	DRB1 alleles in polymyalgia rheumatica and rheumatoid arthritis in southern France. (11251689)	Reviron D.... Roudier J.	2001	HLA-DRB1
28	Seronegative rheumatoid arthritis in elderly and polymyalgia rheumatica have similar patterns of HLA association. (11196513)	Gonzalez-Gay M.A.... Ollier W.	2001	HLA-DRB1
29	RANTES gene polymorphism in polymyalgia rheumatica, giant cell arteritis and rheumatoid arthritis. (10895380)	Makki R.F.... Hajeer A.H.	2000	CCL5
30	Monocyte chemoattractant protein 1 (MCP-1) in temporal arteritis and polymyalgia rheumatica. (11005777)	Ellingsen T.... Stengaard-Pedersen K.	2000	CCL2
31	Absence of the association with CC chemokine receptor 5 polymorphism in polymyalgia rheumatica. (11072599)	Salvarani C.... Di Giovine F.S.	2000	CCR5
32	Interleukin-1 cluster and tumor necrosis factor-alpha gene polymorphisms in polymyalgia rheumatica. (11138328)	Boiardi L.... Di Giovine F.S.	2000	TNF, IL1B, IL1A
33	Vascular endothelial growth factor production in polymyalgia rheumatica. (11083270)	Meliconi R.... Facchini A.	2000	VEGFA
34	Von Willebrand factor in polymyalgia rheumatica and giant cell arteritis. (10948757)	Uddhammar A.C.	2000	VWF
35	Favorable role of interleukin 10 in patients with polymyalgia rheumatica. (10381050)	Straub R.H.... Lang B.	1999	IL1RN, IL1RAPL2
36	Distribution of HLA-DRB1 alleles of patients with polymyalgia rheumatica and giant cell arteritis in a Mediterranean population. (9458210)	Combe B.... Eliaou J.F.	1998	HLA-DRB1
37	Circulating levels of IL-1beta, IL-6 and soluble IL-2 receptor in polymyalgia rheumatica and giant cell arteritis and rheumatoid arthritis. (9714363)	Pountain G.... Cawston T.E.	1998	IL1B, IL2RB
38	Elevated serum concentrations of the chemokine RANTES in patients with polymyalgia rheumatica. (9631747)	Pulsatelli L.... Facchini A.	1998	CXCL1
39	Cytokines and adhesion molecules in patients with polymyalgia rheumatica. (9714354)	Uddhammar A.... RantapAoAo-Dahlqvist S.	1998	IL1RN, IL1RAPL2
40	Antibodies to cardiolipin and beta 2 glycoprotein I in patients with polymyalgia rheumatica and giant cell arteritis. (8738442)	Meyer O.... Kahn M.F.	1996	APOH
41	A randomized controlled trial of salmon calcitonin to prevent bone loss in corticosteroid-treated temporal arteritis and polymyalgia rheumatica. (8998681)	Healey J.H.... Schwartzberg P.	1996	CALCA
42	The CRP initial response to treatment as prognostic f actor in patients with polymyalgia rheumatica. (7641508)	Schreiber S.... Buyse M.	1995	CRP
43	Role of peripheral CD8 lymphocytes and soluble IL-2 receptor in predicting the duration of corticosteroid treatment in polymyalgia rheumatica and giant cell arteritis. (7677440)	Salvarani C.... Portioli I.	1995	IL2RB
44	HLA-DRB1 alleles in polymyalgia rheumatica, giant cell arteritis, and rheumatoid arthritis. (8147928)	Weyand C.M.... Goronzy J.J.	1994	HLA-DRB1
45	Alpha 1-antichymotrypsin, C-reactive protein and eryt hrocyte sedimentation rate in polymyalgia rheumatica and giant cell arteritis. (8205403)	Pountain G.D.... Hazleman B.L.	1994	CRP
46	Correlation of interleukin-6 production and disease activity in polymyalgia rheumatica and giant cell arteritis. (8216422)	Roche N.E.... Weyand C.M.	1993	IL6
47	Plasminogen activator inhibitor and von Willebrand factor in polymyalgia rheumatica. (1617895)	Uddhammar A.... Nilsson T.K.	1992	HP
48	Microheterogeneity of acute phase proteins in the dif ferentiation of polymyalgia rheumatica from polymyositis. (1705291)	Pawlowski T.... Mueller W.	1990	SERPINA3
49	Microheterogeneity of alpha 1-antichymotrypsin in the management of giant-cell arteritis and polymyalgia rheumatica. (2165887)	Hachulla E.... Hayem A.	1990	SERPINA3
50	A case of temporal arteritis associated with polymyalgia rheumatica and subclinical SjAPgren's syndrome (2287968)	Kohriyama K.... Arimori S.	1990	HSPG2

Genes related to polymyalgia rheumatica according to GeneCards:

(show all 37)

id	Symbol	Description	Score	GeneCards Section Context
1	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
2	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
3	IL2RB	interleukin 2 receptor, beta	11.0	Publications
4	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
5	CRP	C-reactive protein, pentraxin-related	11.0	Publications
6	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
7	IL1RAPL2	interleukin 1 receptor accessory protein-like 2	11.0	Publications
8	NM	neutrophil migration	11.0	Publications
9	KRT15	keratin 15	11.0	Publications
10	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11.0	Publications
11	SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	11.0
12	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	11.0	Publications
13	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	11.0	Publications
14	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	11.0	Publications
15	HP	haptoglobin	11.0	Publications
16	IL1R1	interleukin 1 receptor, type I	11.0	Publications
17	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
18	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
19	CRH	corticotropin releasing hormone	11.0	Publications
20	ICAM1	intercellular adhesion molecule 1	11.0	Publications
21	PRL	prolactin	11.0	Publications
22	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0	Publications
23	VWF	von Willebrand factor	11.0	Publications
24	POMC	proopiomelanocortin	11.0	Publications
25	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
26	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
27	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
28	F8	coagulation factor VIII, procoagulant component	11.0	Publications
29	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
30	IL1A	interleukin 1, alpha	11.0	Publications
31	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
32	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
33	IFNG	interferon, gamma	11.0	Publications
34	IL2	interleukin 2	11.0	Publications
35	IL1B	interleukin 1, beta	11.0	Publications
36	TNF	tumor necrosis factor	11.0	Publications
37	VEGFA	vascular endothelial growth factor A	11.0	Publications

Pathways related to polymyalgia rheumatica according to GeneDecks:

(show top 50)    (show all 86)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	10.0	IL1A, IL2
2	IL-6 Pathway36	9.9	CXCL1, CCL5, CCL2, IL12B, IL12A
3	RAR-Gamma-RXR-Alpha Degradation36	9.9	CXCL1, CCL5, IL2, IL12A
4	Immune System38	9.8	ICAM1, IFNG, IL1R1, MX1
5	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.5	IL2RB, IL2RA, IL2
6	Molecular Mechanisms of Cancer36	9.3	CXCL1, CCL5, IL6, IL2, IL1R1, IL12B
7	NFAT Signaling and Lymphocyte Interactions36	9.3	CCL2, IL2RB, IL2, IL1A, IL12B, IL12A
8	Jak-STAT signaling pathway20	9.1	PRL, IL2RB, IL2RA, IL2, IL12B, IL12A
9	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.7	TNF, IL2RB, IL2RA, IL2, IL12A
10	PGC1Alpha Pathway36	8.7	CCL5, IL2RB, IL2, IL1R1, IL1B, IL1A
11	Tec Kinases Signaling36	8.6	CCL5, CCR5, CCL2, IL6, IL2RB, IL2RA
12	Allograft rejection20	8.5	TNF, HLA-DRB1, IFNG, IL2, IL12B, IL12A
13	Regulation of eIF4 and p70S6K36	8.5	CCL5, IL6, IL2, IL1A, IL12B, IL12A
14	Endothelin-1 Signaling Pathway36	8.3	CXCL1, CCL5, IL6, IL2, IL1B, IL1A
15	THC Differentiation Pathway36	8.2	TNF, HLA-DRB1, IFNG, IL2RA, IL2, IL12B
16	Immune response_MIF-mediated glucocorticoid regulation41	8.1	IL6, IFNG, ICAM1, TNF, NR3C1, IL2
17	Immune response MIF-mediated glucocorticoid regulation10	8.1	NR3C1, TNF, ICAM1, IFNG, IL6, IL2
18	MSP-RON Signaling36	8.1	TNF, IFNG, CCL2, IL1B, IL12B, IL12A
19	Leishmaniasis20	8.1	TNF, HLA-DRB1, IFNG, IL1B, IL1A, IL12B
20	SOCS Pathway36	8.0	CCL5, CCL2, IL6, IL2, IL1B, IL1A
21	African trypanosomiasis20	8.0	TNF, ICAM1, IFNG, IL6, IL1B, IL12B
22	NOD-like receptor signaling pathway20	7.9	CXCL1, TNF, CCL5, CCL2, IL6, IL1B
23	Rho Family GTPases36	7.9	CXCL1, HSPG2, CCL5, CCL2, IL2, IL1B
24	Amoebiasis20	7.8	CXCL1, TNF, IFNG, IL6, IL1R1, IL1B
25	Malaria20	7.8	TNF, ICAM1, IFNG, CCL2, IL6, IL1B
26	Hematopoietic cell lineage20	7.8	TNF, HLA-DRB1, IL6, IL2RA, IL1R1, IL1B
27	ERK Signaling36	7.7	HSPG2, CCL5, IL6, IL2, IL1B, IL1A
28	Type I diabetes mellitus20	7.7	TNF, HLA-DRB1, IFNG, IL2, IL1B, IL1A
29	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	7.7	NR3C1, TNF, CALCA, IFNG, IL6, IL1B
30	Transcription Role of VDR in regulation of genes involved in osteoporosis10	7.7	NR3C1, TNF, CALCA, IFNG, IL6, IL1B
31	Akt Signaling36	7.6	IL12B, IL2, IL2RA, IL2RB, IL6, CCL2
32	Measles20	7.6	IFNG, IL6, IL2RB, IL2RA, IL2, IL1B
33	TGF-Beta Pathway36	7.5	CCL5, CCL2, IL6, IL2RB, IL2RA, IL2
34	Cytokine Network36	7.4	TNF, IFNG, IL6, IL2, IL1B, IL1A
35	Tuberculosis20	7.4	TNF, HLA-DRB1, IFNG, IL6, IL1B, IL1A
36	Glucocorticoid Receptor Signaling36	7.4	NR3C1, CCL5, CCL2, IL6, IL2RB, IL2RA
37	Chagas disease (American trypanosomiasis)20	7.3	TNF, IFNG, CCL5, CCL2, IL6, IL2
38	MIF Regulation of Innate Immune Cells36	7.3	CXCL1, TNF, CCL5, CCL2, IL6, IL2
39	all-trans-Retinoic Acid Signaling in Brain36	7.2	CCL2, CCL5, TNF, CXCL1, IL6, IL2
40	PEDF Induced Signaling36	7.2	CCL2, CCL5, TNF, CXCL1, IL6, IL2
41	MIF Mediated Glucocorticoid Regulation36	7.1	IL12A, IL12B, CXCL1, NR3C1, TNF, CCL5
42	Influenza A20	7.1	TNF, HLA-DRB1, ICAM1, IFNG, CCL5, CCL2
43	JAK-STAT Pathway36	6.9	IL1B, IL1R1, IL2, IL2RA, IL2RB, IL6
44	PAK Pathway36	6.8	CXCL1, TNF, CCL5, CCL2, IL6, IL2RA
45	MAPK Family Pathway36	6.7	IL2RB, IL6, CCL2, CCL5, TNF, IL2RA
46	Rheumatoid arthritis20	6.6	TNF, HLA-DRB1, ICAM1, IFNG, CCL5, CCL2
47	STAT3 Pathway36	6.3	IL12A, IL12B, IL1A, CXCL1, TNF, CCL5
48	Antioxidant Action of Vitamin-C36	6.3	IL6, CCL2, CCR5, CCL5, TNF, CXCL1
49	p38 Signaling36	6.3	IL6, CCL2, CCR5, CCL5, TNF, CXCL1
50	Cytokine-cytokine receptor interaction20	5.2	VEGFA, CXCL1, PRL, TNF, IFNG, CCL5

Compounds related to polymyalgia rheumatica according to GeneDecks:

(show top 50)    (show all 313)

id	Compound	Score	Top Affiliating Genes
1	n acetylcysteine32	9.8	VWF, MMP3, IL1R1, IL2RA, IL2RB
2	ivig32	9.6	CRP, F8, CCR5, IL1RAPL2, VWF
3	endotoxin32	9.4	IL12B, IL1R1, IL1RAPL2, IL2RB, APOH, F8
4	rituximab32 34 9 9	12.4	IL1R1, IL2, IL2RA, F8, CRP
5	pge232	9.1	MMP3, IL1A, IL1R1, IL1RAPL2, IL1RN, CCL5
6	epinephrine32 9 18 9	12.0	IL1A, IL1RAPL2, IL1RN, CCL5, F8, HP
7	heparin32 9 18 9	11.8	VWF, SERPINA3, MMP3, IL1RAPL2, IL1RN, CCL5
8	anakinra32 9 9	10.5	IL1B, IL1R1, IL1RAPL2, IL1RN, IL6, TNF
9	adalimumab32 9 9	10.5	MMP3, IL1R1, IL1RAPL2, IL1RN, IL6, IFNG
10	testosterone32 9 18 9	11.4	IL1R1, IL1A, IL1RAPL2, IL1RN, IL2RA, CALCA
11	aspirin32 34 18	10.4	IL1RN, IL2RA, IL2RB, APOH, CCL5, F8
12	corticosterone32 18	9.3	IL1B, IL1R1, IL1RAPL2, IL1RN, CCL2, CALCA
13	polysulfone32	8.3	IL2RA, IL2RB, CRP, IL1RN, IL1RAPL2, VWF
14	estrogen32	8.1	VWF, SERPINA3, MMP3, IL1RN, APOH, F8
15	ribonucleic acid32	8.0	POMC, CXCL1, MMP3, IL1A, IL1B, IL1R1
16	vitamin d32	7.9	MMP3, IL12B, IL1A, IL1R1, IL1RN, IL2RA
17	acth32	7.7	HP, IL6, IL2RB, IL1RN, IL1R1, IL1B
18	leukotriene b432 42 18	9.6	IL1B, IL1R1, IL1RAPL2, IL1RN, IL2RB, IL6
19	etanercept32 9 9	9.6	MMP3, IL1B, IL1R1, IL1RAPL2, IL1RN, IL2RB
20	groalpha32	7.6	TNF, CXCL1, ICAM1, CCL5, CCR5, IL1A
21	sb 20358032 42	8.5	IL6, IL1R1, MMP3, VEGFA, CCL5, IFNG
22	histamine32 18	8.5	VWF, IL1RAPL2, IL1RN, IL2, IL2RA, IL2RB
23	norepinephrine32 9 18 9	10.4	IL2RB, IL6, CCL2, F8, CALCA, CRH
24	il-1232	7.4	IL12B, IL1B, IL1R1, IL2, IL6, CCL2
25	sulfasalazine32 9 9	9.4	IL1B, IL1R1, IL1RAPL2, IL1RN, IL2RA, CCL2
26	creatinine32	7.3	HP, F8, CCL5, CCL2, APOH, IL2RB
27	fibrinogen32	7.2	CCL2, VWF, CRP, TNF, SERPINA3, ICAM1
28	gold sodium thiomalate32	7.1	IL1A, IL1B, IL1R1, IL1RN, IL2, IL2RA
29	methotrexate32 34 42 9 9	11.0	MMP3, IL1B, IL1R1, IL1RAPL2, IL1RN, IL2RA
30	ccl332	7.0	TNF, CXCL1, ICAM1, IFNG, CCL5, IL1A
31	lactate32	6.9	CRP, NR3C1, TNF, VWF, MMP3, IL1R1
32	rantes32	6.8	IL6, CCL2, CCR5, CCL5, IFNG, ICAM1
33	triptolide32	6.7	TNF, VEGFA, MMP3, IL1B, IL2, IL6
34	gm-csf32	6.5	IFNG, ICAM1, TNF, CCL5, CCL2, IL6
35	vegf32	6.5	IL1RN, APOH, CCL2, CCL5, F8, ICAM1
36	infliximab32 9 9	8.5	VEGFA, MMP3, IL1B, IL1R1, IL1RAPL2, IL1RN
37	pentoxifylline32 9 9	8.3	TNF, HP, IL12B, IL1A, IL1B, IL1R1
38	simvastatin32 34 42 9 18 9	11.2	IL6, IL1RN, IL1RAPL2, IL1A, MMP3, VEGFA
39	hydrocortisone32 9 9	8.2	IL1A, IL1B, IL1R1, IL1RN, IL2, IL6
40	neopterin32	6.1	MX1, IL1A, IL1B, IL1R1, IL1RAPL2, IL1RN
41	prednisolone32 9 9	8.1	POMC, CRP, NR3C1, IL1R1, MMP3, VWF
42	il 1032	5.9	IL1B, IL1R1, IL1RAPL2, IL1RN, IL2, IL2RA
43	indomethacin32 9 9	7.7	MMP3, IL1A, IL1B, IL1R1, IL1RAPL2, IL1RN
44	retinoic acid32 42 18	7.7	KRT15, CXCL1, NR3C1, TNF, HSPG2, VWF
45	nitric oxide32 9 18 9	8.5	IL1RN, IL2RB, IL6, APOH, CCL2, CCL5
46	cyclosporin a32 42	6.2	IL2RB, IL6, CCR5, CCL5, IFNG, F8
47	genistein32 9 18 9	8.2	IL2RB, CCL2, CCL5, IFNG, ICAM1, HSPG2
48	actinomycin d32	5.2	VEGFA, IL1A, IL1B, IL1R1, IL1RAPL2, IL2
49	cycloheximide32	4.2	VEGFA, CRH, CRP, CXCL1, POMC, NR3C1
50	dexamethasone32 42 34 9 9	6.8	NR3C1, POMC, CXCL1, PRL, CRH, VWF

Cellular components related to polymyalgia rheumatica according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-12 complex	GO:043514	9.9	IL12A, IL12B
2	external side of plasma membrane	GO:009897	8.2	TNF, HLA-DRB1, ICAM1, IFNG, CCR5, IL2RB
3	cell surface	GO:009986	8.1	CCR5, APOH, IL1R1, IL1A, VEGFA, TNF
4	extracellular region	GO:005576	4.6	F8, HSPG2, CALCA, HP, CRH, CRP
5	extracellular space	GO:005615	3.7	VEGFA, F8, ICAM1, HSPG2, CALCA, HP

Biological processes related to polymyalgia rheumatica according to GeneDecks:

(show top 50)    (show all 63)

id	Name	GO ID	Score	Top Affiliating Genes
1	chronic inflammatory response to antigenic stimulus	GO:002439	10.2	IL1B, IL1RN
2	cellular response to interferon-gamma	GO:071346	10.2	CCL5, CCL2, IL12B
3	positive regulation of smooth muscle cell apoptotic process	GO:034393	10.1	IL12A, IL12B, IFNG
4	defense response to protozoan	GO:042832	10.1	IL12A, IL12B, IFNG
5	negative regulation of interleukin-17 production	GO:032700	10.1	IL12A, IL12B, IFNG
6	positive regulation of JAK-STAT cascade	GO:046427	10.1	PRL, CCL5, IL6
7	blood coagulation, intrinsic pathway	GO:007597	10.0	F8, APOH, VWF
8	interleukin-2-mediated signaling pathway	GO:038110	10.0	IL2RA, IL2RB
9	leukocyte cell-cell adhesion	GO:007159	10.0	CCL5, ICAM1, CALCA
10	chemokine-mediated signaling pathway	GO:070098	9.9	CCL5, CCR5, CCL2
11	acute-phase response	GO:006953	9.9	CRP, F8, IL6, IL1RN, SERPINA3
12	negative regulation of smooth muscle cell proliferation	GO:048662	9.8	IFNG, IL12B, IL12A
13	monocyte chemotaxis	GO:002548	9.8	IL6, CCL2, CCL5, CALCA
14	negative regulation of lipid storage	GO:010888	9.5	IL6, TNF, CRP
15	positive regulation of cell adhesion	GO:045785	9.5	IFNG, CCL5, IL12B, IL12A, VEGFA
16	cellular response to lipopolysaccharide	GO:071222	9.5	ICAM1, IFNG, CCR5, CCL2, IL12B
17	fever generation	GO:001660	9.4	IL1A, IL1B
18	positive regulation of vitamin D biosynthetic process	GO:060557	9.4	IFNG, TNF
19	negative regulation of viral genome replication	GO:045071	9.4	TNF, CCL5, MX1
20	response to activity	GO:014823	9.4	NR3C1, TNF, CCL5, CCL2
21	positive regulation of osteoclast differentiation	GO:045672	9.3	TNF, IFNG, CCL5, IL12B
22	negative regulation of growth of symbiont in host	GO:044130	9.3	TNF, IFNG, IL12B
23	aging	GO:007568	9.3	NR3C1, CALCA, CCL5, CCL2, IL1B
24	positive regulation of fever generation	GO:031622	9.3	IL1B, CCL5, TNF
25	positive regulation of NF-kappaB import into nucleus	GO:042346	9.2	TNF, IL1B, IL12B
26	cell surface receptor signaling pathway	GO:007166	9.1	PRL, IFNG, CCR5, CCL2, IL2RA, IL1R1
27	positive regulation of angiogenesis	GO:045766	9.0	CCL5, IL1B, IL1A, VEGFA
28	response to virus	GO:009615	9.0	TNF, IFNG, CCL5, IL12A, MX1
29	positive regulation of T cell proliferation	GO:042102	9.0	IFNG, CCL5, IL6, IL1B, IL12B, IL12A
30	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.0	IL1B, IFNG, TNF
31	protein kinase B signaling cascade	GO:043491	9.0	TNF, CCL5, CCL2, IL1B
32	lipopolysaccharide-mediated signaling pathway	GO:031663	9.0	IL1B, CCL2, CCL5, TNF
33	cellular response to organic cyclic compound	GO:071407	9.0	TNF, CCL5, CCL2, IL1B
34	positive regulation of chemokine biosynthetic process	GO:045080	8.9	TNF, IFNG, IL1B
35	positive regulation of membrane protein ectodomain proteolysis	GO:051044	8.9	TNF, IFNG, IL1B
36	humoral immune response	GO:006959	8.8	IL6, CCL2, IFNG, TNF
37	positive regulation of nitric oxide biosynthetic process	GO:045429	8.8	TNF, ICAM1, IFNG, IL1B
38	cell-cell signaling	GO:007267	8.7	POMC, CALCA, CCL5, CCR5, IL2, IL1B
39	sequestering of triglyceride	GO:030730	8.7	IL1B, TNF
40	MAPK cascade	GO:000165	8.7	TNF, CCL5, CCR5, CCL2, IL1B
41	immune response	GO:006955	8.7	CXCL1, HLA-DRB1, CCR5, IL2RA, IL2, IL1RN
42	response to drug	GO:042493	8.7	TNF, ICAM1, IFNG, CCL5, CCL2, IL1RN
43	positive regulation of interferon-gamma production	GO:032729	8.6	TNF, IL2, IL1B, IL12B, IL12A
44	positive regulation of interleukin-6 production	GO:032755	8.6	TNF, IL6, IL1B, IL1A
45	response to glucocorticoid stimulus	GO:051384	8.5	TNF, CCL5, CCL2, IL6, IL1RN, IL1B
46	cytokine-mediated signaling pathway	GO:019221	8.2	HLA-DRB1, ICAM1, IFNG, CCL2, IL6, IL2RB
47	response to hypoxia	GO:001666	8.1	CRP, TNF, CCL2, IL1B, IL1A, VEGFA
48	anti-apoptosis	GO:006916	8.0	NR3C1, TNF, CCL2, IL2, IL1B, IL1A
49	inflammatory response	GO:006954	7.2	SERPINA3, CXCL1, CRP, CRH, TNF, CALCA
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.8	POMC, TNF, IFNG, IL6, IL2, IL1B

Molecular functions related to polymyalgia rheumatica according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-2 receptor activity	GO:004911	10.0	IL2RA, IL2RB
2	interleukin-1 receptor binding	GO:005149	9.4	IL1RN, IL1B, IL1A
3	hormone activity	GO:005179	9.3	POMC, PRL, CRH, CALCA
4	growth factor activity	GO:008083	8.0	CXCL1, IL6, IL2, IL1B, IL12B, IL12A
5	cytokine activity	GO:005125	6.6	VEGFA, TNF, IFNG, IL6, IL2, IL1B
6	protein binding	GO:005515	5.3	ICAM1, HSPG2, CALCA, TNF, SULT2A1, NR3C1