MCID: PLY013
MIFTS: 45

Polymyalgia Rheumatica malady

Bone diseases, Rare diseases categories

Summaries for Polymyalgia Rheumatica

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MedlinePlus:32 Polymyalgia rheumatica is a disorder that causes muscle pain and stiffness in your neck, shoulders, and hips. it is most common in women and almost always occurs in people over 50. the main symptom is stiffness after resting. other symptoms include fever, weakness and weight loss. in some cases, polymyalgia rheumatica develops overnight. in others, it is gradual. the cause is not known. there is no single test to diagnose polymyalgia rheumatica. your doctor will use your medical history, symptoms, and a physical exam to make the diagnosis. lab tests for inflammation may help confirm the diagnosis. polymyalgia rheumatica sometimes occurs along with giant cell arteritis, a condition that causes swelling of the arteries in your head. symptoms include headaches and blurred vision. doctors often prescribe prednisone, a steroid medicine, for both conditions. with treatment, polymyalgia rheumatica usually disappears in a day or two. without treatment, it usually goes away after a year or more. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Polymyalgia Rheumatica, also known as rhizomelic pseudopolyarthritis, is related to synovitis and amyloidosis. An important gene associated with Polymyalgia Rheumatica is IL1RN (interleukin 1 receptor antagonist), and among its related pathways are Signaling by Interleukins and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds gold sodium thiomalate and cuprophan have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone, and related mouse phenotype immune system.

Wikipedia:63 Polymyalgia rheumatica (which takes its name from the word ??????????? \"polymyalgia\" which means... more...

Aliases & Classifications for Polymyalgia Rheumatica

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Sources:
9Disease Ontology, 43Novoseek, 47Orphanet, 32MedlinePlus, 60UMLS, 33MeSH, 27ICD9CM, 55SNOMED-CT, 38NCIt, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Polymyalgia Rheumatica, Aliases & Descriptions:

Name: Polymyalgia Rheumatica 9 43 47 32 60
Rhizomelic Pseudopolyarthritis 47 60
 
Giant Cell Arteritis 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology9 DOID:853
MeSH33 D011111
ICD9CM27 725
NCIt38 C85018
Orphanet47 93569
UMLS via Orphanet61 C1527406
ICD10 via Orphanet26 M35.3
ICD1025 M35.3

Related Diseases for Polymyalgia Rheumatica

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Diseases related to Polymyalgia Rheumatica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1synovitis31.3CRP, IL1RN
2amyloidosis30.8CRP, SERPINA3
3hepatitis30.8HLA-DRB1, IL2RB
4bronchiolitis30.7CCL5
5myositis30.6IL1RN, SERPINA3
6arthropathy30.6CRP, IL1RN
7primary biliary cirrhosis30.5HLA-DRB1, IL2RB
8pneumonia30.5CRP, IL2RB, CCL5
9arthritis30.4HLA-DRB1, SERPINA3, CCL5, IL2RB, IL1RN, CRP
10rheumatoid arthritis30.3HLA-DRB1, SERPINA3, CCL5, IL2RB, IL1RN, CRP
11ulcerative colitis30.3HLA-DRB1, IL1RN, CRP
12myocardial infarction30.0SERPINA3, CCL5, CRP
13atherosclerosis29.9CRP, IL1RN, CCL5
14temporal arteritis11.1
15vasculitis10.8
16bursitis10.7
17influenza10.6
18blindness10.5
19hyper-igd syndrome10.5IL1RN
20schnitzler syndrome10.5IL1RN
21dengue shock syndrome10.5IL1RN
22malignant histiocytosis10.4SERPINA3
23aortic aneurysm10.4
24cellulitis10.4
25cervicitis10.4
26prostatitis10.4
27spondylitis10.4
28spondyloarthropathy10.4
29aneurysm10.4
30emphysema due to aat deficiency10.4SERPINA3
31adult-onset still's disease10.4CRP
32skin disease10.4HLA-DRB1
33carotid stenosis10.4CRP
34prostate cancer10.4
35osteoporosis10.4
36hodgkin lymphoma10.4
37childhood type dermatomyositis10.4
38leukemia10.4
39peripheral artery disease10.4
40aortitis10.4
41miliary tuberculosis10.4
42gout10.4
43artery disease10.4
44endocarditis10.4
45meningitis10.4
46myeloid leukemia10.4
47pericardial effusion10.4
48tuberculosis10.4
49endotheliitis10.4
50acute graft versus host disease10.3IL1RN, IL2RB

Graphical network of the top 20 diseases related to Polymyalgia Rheumatica:



Diseases related to polymyalgia rheumatica

Symptoms for Polymyalgia Rheumatica

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Drugs & Therapeutics for Polymyalgia Rheumatica

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Drug clinical trials:

Search ClinicalTrials for Polymyalgia Rheumatica

Search NIH Clinical Center for Polymyalgia Rheumatica

Genetic Tests for Polymyalgia Rheumatica

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Anatomical Context for Polymyalgia Rheumatica

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MalaCards organs/tissues related to Polymyalgia Rheumatica:

31
Testes, Skin, Bone, Pituitary, T cells, Colon, Prostate, Skeletal muscle, Myeloid, B cells, Endothelial, Kidney, Adrenal gland, Breast, Monocytes, Neutrophil

Animal Models for Polymyalgia Rheumatica or affiliated genes

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MGI Mouse Phenotypes related to Polymyalgia Rheumatica:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.7CRP, IL1RN, IL2RB, IL12A, CCL5

Publications for Polymyalgia Rheumatica

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Articles related to Polymyalgia Rheumatica:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
Polymyalgia rheumatica: inflammation suppression with low dose of methylprednisolone or modified-release prednisone. (25807425)
2015
2
Influence of interleukin 10 promoter polymorphisms in polymyalgia rheumatica: disease susceptibility and functional consequences. (24983912)
2014
3
14. A double-blind, randomized, placebo-controlled pilot study of leflunomide in polymyalgia rheumatica. (25079166)
2014
4
Giant cell arteritis and polymyalgia rheumatica after reexposure to a statin: a case report. (25329212)
2014
5
ARDS with septic shock due to Legionella longbeachae pneumonia in a patient with polymyalgia rheumatica. (25024993)
2014
6
Polymyalgia rheumatica. (24301266)
2013
7
Polymyalgia rheumatica and giant cell arteritis. (24364492)
2013
8
2012 Provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. (22389040)
2012
9
Addison's disease masked by long-term exogenous steroid treatment for presumed polymyalgia rheumatica. (22372233)
2012
10
Provisional diagnostic criteria for polymyalgia rheumatica: moving beyond clinical intuition? (22388994)
2012
11
Response to 'Effect of etanercept in polymyalgia rheumatica: a randomized controlled trial'. (21542877)
2011
12
Ultrasonographic monitoring of response to therapy in polymyalgia rheumatica. (19773289)
2010
13
Concise guidance: diagnosis and management of polymyalgia rheumatica. (20726461)
2010
14
Can the prognosis of polymyalgia rheumatica be predicted at disease onset? Results from a 5-year prospective study. (20064872)
2010
15
Presentations of perforated colonic pathology in patients with polymyalgia rheumatica: two case reports. (20819228)
2010
16
A case of cold agglutinin disease in the course of treatment for polymyalgia rheumatica. (19340395)
2009
17
Serum interleukin-6 receptor in polymyalgia rheumatica: a potential marker of relapse/recurrence risk. (18668607)
2008
18
The clinical implication of cervical interspinous bursitis in the diagnosis of polymyalgia rheumatica. (18474656)
2008
19
Small-vessel vasculitis surrounding an uninflamed temporal artery: a new diagnostic criterion for polymyalgia rheumatica? (18668584)
2008
20
Repetitive 18-fluorodeoxyglucose positron emission tomography in isolated polymyalgia rheumatica: a prospective study in 35 patients. (17114803)
2007
21
Unilateral polymyalgia rheumatica with controlateral sympathetic dystrophy syndrome. A case of asymmetrical involvement due to pre-existing peripheral palsy. (17085469)
2006
22
Synovial expression of vasoactive intestinal peptide in polymyalgia rheumatica. (17181926)
2006
23
Polymyalgia rheumatica: diagnosis and treatment. (17113808)
2006
24
Do steroids increase lymphoma risk? A case-control study of lymphoma risk in polymyalgia rheumatica/giant cell arteritis. (15843445)
2005
25
Calcium pyrophosphate deposition disease mimicking polymyalgia rheumatica: a prospective followup study of predictive factors for this condition in patients presenting with polymyalgia symptoms. (16342107)
2005
26
Crowned dens syndrome misdiagnosed as polymyalgia rheumatica, giant cell arteritis, meningitis or spondylitis: an analysis of eight cases. (15316123)
2004
27
Giant-cell arteritis and polymyalgia rheumatica. (13679329)
2003
28
Genetic markers of disease susceptibility and severity in giant cell arteritis and polymyalgia rheumatica. (12920695)
2003
29
Polymyalgia rheumatica and giant-cell arteritis. (12494941)
2002
30
Sex differences in temporal arteritis and polymyalgia rheumatica. (11838850)
2002
31
Ultrasonography of temporal arteries discloses temporal arteritis in "pure" polymyalgia rheumatica patients. (12532975)
2002
32
Polymyalgia rheumatica revisited. (11591045)
2001
33
Polymyalgia rheumatica: pitfalls in diagnosis. (11385095)
2001
34
Polymyalgia rheumatica and giant cell arteritis. Avoiding management traps. (11558196)
2001
35
Polymyalgia rheumatica: evidence for a hypothalamic-pituitary-adrenal axis-driven disease. (11138324)
2000
36
Epidemiology of polymyalgia rheumatica. (10948749)
2000
37
Polymyalgia rheumatica and temporal arthritis. (10969858)
2000
38
Management of giant cell arteritis and polymyalgia rheumatica. (10779249)
2000
39
Distribution of HLA-DRB1 alleles of patients with polymyalgia rheumatica and giant cell arteritis in a Mediterranean population. (9458210)
1998
40
Effects of glucocorticoids on bone mass in patients with polymyalgia rheumatica. A longitudinal study. (9779318)
1998
41
Elevated serum concentrations of the chemokine RANTES in patients with polymyalgia rheumatica. (9631747)
1998
42
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Patients starting steroids should be given advice on risk of osteoporosis. (9329330)
1997
43
Spondyloarthropathy presenting as a polymyalgia rheumatica-like syndrome. (9456015)
1997
44
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Sensitivity of temporal artery biopsy varies with biopsy length and sectioning strategy. (9329326)
1997
45
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Oral prednisolone 40 mg daily is not adequate for temporal arteritis once vision is affected. (9329327)
1997
46
A randomized controlled trial of salmon calcitonin to prevent bone loss in corticosteroid-treated temporal arteritis and polymyalgia rheumatica. (8998681)
1996
47
Non-giant cell arteritis of the temporal artery presenting as the polymyalgia rheumatica-temporal arteritis syndrome. (8596167)
1995
48
Subclavian and axillary involvement in temporal arteritis and polymyalgia rheumatica. (2294760)
1990
49
Temporal arteritis after normalization of erythrocyte sedimentation rate in polymyalgia rheumatica. (3778060)
1986
50
Granulomatous angiitis presenting with polymyalgia rheumatica and abnormal pituitary function. (3966760)
1985

Variations for Polymyalgia Rheumatica

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Expression for genes affiliated with Polymyalgia Rheumatica

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Search GEO for disease gene expression data for Polymyalgia Rheumatica.

Pathways for genes affiliated with Polymyalgia Rheumatica

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Pathways related to Polymyalgia Rheumatica according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7IL2RB, IL1RN
2
Show member pathways
9.5IL12A, IL2RB
3
Show member pathways
thioredoxin pathway36
9.4SERPINA3, CRP
4
Show member pathways
9.2IL2RB, IL1RN, HLA-DRB1
59.1CCL5, HLA-DRB1
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.0SERPINA3, IL1RN, CRP
7
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.0IL12A, IL2RB, HLA-DRB1
8
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
9.0HLA-DRB1, IL12A, IL2RB
9
Show member pathways
8.7IL2RB, IL12A, CCL5
10
Show member pathways
8.7IL2RB, IL12A, CCL5
11
Show member pathways
8.7IL2RB, CCL5, IL12A
12
Show member pathways
8.7CCL5, IL12A, IL2RB
13
Show member pathways
8.2IL12A, IL2RB, CCL5, HLA-DRB1

Compounds for genes affiliated with Polymyalgia Rheumatica

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Compounds related to Polymyalgia Rheumatica according to GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1gold sodium thiomalate439.9IL1RN, HLA-DRB1
2cuprophan439.9IL2RB, IL1RN
3anakinra43 1210.9IL1RN, CRP
4adalimumab43 49 1211.8CRP, IL1RN
5polysulfone439.5IL1RN, IL2RB, CRP
6etanercept43 49 1211.5IL2RB, IL1RN, CRP
7infliximab43 49 1211.5IL2RB, IL1RN, CRP
8ivig439.5CRP, IL1RN, IL2RB
9neopterin439.5CRP, IL1RN, IL2RB
10glatiramer acetate43 1210.5HLA-DRB1, CCL5
11bryostatin 1439.5CCL5, IL2RB
12p003439.5CRP, IL2RB, IL1RN
13prednisolone43 28 1211.5CRP, IL1RN, IL2RB
14methionine439.4IL1RN, SERPINA3, IL2RB
15vitamin a43 24 1211.3SERPINA3, IL1RN, CRP
16pmma439.3CRP, CCL5
17il 10439.3IL1RN, IL2RB, CCL5
18leukotriene b443 59 2411.3CCL5, IL1RN, IL2RB
19mycophenolic acid43 49 1211.2IL2RB, CCL5
20fmlp439.2CCL5, IL1RN, SERPINA3
21rantes439.2IL2RB, CCL5, IL1RN
22nacl439.2SERPINA3, IL1RN, CCL5
23ribonucleic acid439.2IL2RB, IL1RN, CCL5
24ionomycin439.2CCL5, IL2RB, SERPINA3
25amphotericin b439.1CCL5, IL1RN, CRP
26methacholine43 49 1211.0CRP, IL2RB, CCL5
27simvastatin43 49 59 28 24 1214.0IL1RN, CRP, CCL5
28iron43 2410.0IL1RN, CRP, SERPINA3, IL2RB
29azathioprine43 2 49 1212.0CRP, CCL5, IL2RB
30folate438.9CRP, SERPINA3, CCL5
31fibrinogen438.9IL1RN, CRP, SERPINA3
32sb 20358043 599.9CRP, IL1RN, CCL5
33n acetylcysteine438.9CRP, IL2RB, CCL5
34histamine43 28 2410.9CCL5, IL2RB, IL1RN
35norepinephrine43 24 1210.8IL1RN, IL2RB, CRP
36dexamethasone43 49 28 1211.8CCL5, IL2RB, IL1RN, SERPINA3
37zinc43 249.7IL1RN, SERPINA3, IL2RB, CCL5
38endotoxin438.7CRP, IL2RB, CCL5, IL1RN
39aspirin43 49 28 2411.7IL2RB, CCL5, IL1RN, CRP
40lactate438.7IL1RN, CRP, IL2RB, CCL5
41cycloheximide438.6CCL5, IL1RN, CRP, IL2RB
42retinoic acid43 249.6IL1RN, IL2RB, CCL5, SERPINA3
43vegf438.6CCL5, IL2RB, CRP, IL1RN
44creatinine438.2IL1RN, CRP, IL2RB, SERPINA3, CCL5
45glucose438.2IL2RB, CRP, SERPINA3, CCL5
46cholesterol43 28 24 1211.2IL2RB, CRP, CCL5, IL1RN, SERPINA3
47lipid438.2SERPINA3, CRP, CCL5, IL2RB, IL1RN
48calcium43 49 24 1210.9IL2RB, IL1RN, CCL5, SERPINA3, CRP
49methotrexate49 43 129.7CRP, IL2RB, CCL5, SERPINA3, HLA-DRB1, IL1RN
50alanine437.7IL2RB, HLA-DRB1, SERPINA3, CCL5, IL1RN, CRP

GO Terms for genes affiliated with Polymyalgia Rheumatica

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Cellular components related to Polymyalgia Rheumatica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1CRP, IL1RN, IL12A, CCL5

Biological processes related to Polymyalgia Rheumatica according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1defense response to Gram-positive bacteriumGO:00508309.4IL12A, CRP
2protein tetramerizationGO:00512629.3CCL5, HLA-DRB1
3acute-phase responseGO:00069539.2CRP, IL1RN, SERPINA3
4positive regulation of cell adhesionGO:00457859.1IL12A, CCL5
5response to virusGO:00096159.1IL12A, CCL5
6immune responseGO:00069559.0HLA-DRB1, IL12A, IL1RN
7positive regulation of T cell proliferationGO:00421028.8IL12A, CCL5
8inflammatory responseGO:00069548.7CRP, CCL5, SERPINA3

Products for genes affiliated with Polymyalgia Rheumatica

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Sources for Polymyalgia Rheumatica

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet