MCID: PLY013
MIFTS: 56

Polymyalgia Rheumatica malady

Bone diseases category

Summaries for Polymyalgia Rheumatica

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Polymyalgia rheumatica is a disorder that causes muscle pain and stiffness in your neck, shoulders, and hips. it is most common in women and almost always occurs in people over 50. the main symptom is stiffness after resting. other symptoms include fever, weakness and weight loss. in some cases, polymyalgia rheumatica develops overnight. in others, it is gradual. the cause is not known. there is no single test to diagnose polymyalgia rheumatica. your doctor will use your medical history, symptoms, and a physical exam to make the diagnosis. lab tests for inflammation may help confirm the diagnosis. polymyalgia rheumatica sometimes occurs along with giant cell arteritis, a condition that causes swelling of the arteries in your head. symptoms include headaches and blurred vision. doctors often prescribe prednisone, a steroid medicine, for both conditions. with treatment, polymyalgia rheumatica usually disappears in a day or two. without treatment, it usually goes away after a year or more. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Polymyalgia Rheumatica, also known as rhizomelic pseudopolyarthritis, is related to arthritis and rheumatoid arthritis. An important gene associated with Polymyalgia Rheumatica is IL1RN (interleukin 1 receptor antagonist), and among its related pathways are Malaria and PEDF Induced Signaling. The compounds estrogen and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone, and related mouse phenotype immune system.

Wikipedia:63 Polymyalgia rheumatica (which takes its name from the word \"polymyalgia\" which means \"pain in many... more...

Aliases & Classifications for Polymyalgia Rheumatica

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Sources:
8Disease Ontology, 44Novoseek, 48Orphanet, 33MedlinePlus, 56SNOMED-CT, 27ICD9CM, 39NCIt, 60UMLS, 34MeSH, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

polymyalgia rheumatica 8 44 48 33
rhizomelic pseudopolyarthritis 48


External Ids:

Disease Ontology8 DOID:853
ICD9CM27 725
NCIt39 C85018
MeSH34 D011111
UMLS via Orphanet61 C1527406
ICD10 via Orphanet26 M31.6
ICD1025 M35.3

Related Diseases for Polymyalgia Rheumatica

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17GeneCards, 18GeneDecks
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Diseases related to Polymyalgia Rheumatica via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.3CRP, HLA-DRB1, CCL5, HP, CXCL1, IL1RN
2rheumatoid arthritis31.3CCL5, TLR9, SERPINA3, MMP3, IL2RB, IL1RAPL2
3vasculitis31.0IL1RAPL2, CXCL1, CRP, APOH
4synovitis30.9MMP3, IL1R1, IL1RN, CRP
5influenza30.8CCL5, TLR9, IL2RB, MX1
6aortic aneurysm30.6CRP
7amyloidosis30.5CRP, IL1RAPL2, SERPINA3
8pneumonia30.5CCL5, CRP, CXCL1, IL1RAPL2, IL2RB
9meningitis30.4CRP, CXCL1
10hepatitis30.4HP, IL1RAPL2, IL2RB, MX1
11diabetes mellitus30.4MMP3, IL1R1, HP, CRP, HLA-DRB1
12tuberculosis30.4TLR9, HLA-DRB1, CRP, HP, IL12B, IL1RAPL2
13prostate cancer30.4CCL5, TLR9, CXCL1, IL1R1, MX1, SERPINA3
14leukemia30.4HLA-DRB1, HP, CXCL1, IL12B, IL1R1, IL1RAPL2
15bronchiolitis30.2CCL5
16uveitis30.2IL1R1
17adenocarcinoma30.2SERPINA3, IL1RAPL2, CCL5
18myositis30.2SERPINA3, IL1RAPL2, IL1RN
19neutropenia30.2IL1RN
20dementia30.2IL1RAPL2, MMP3, SERPINA3
21myocardial infarction30.2SERPINA3, IL1RAPL2, CRP, CCL5
22glomerulonephritis30.2IL1R1, IL1RN, TLR9
23ischemia30.2HP, IL2RB, MMP3
24arthropathy30.2CRP, IL1RN, IL1RAPL2, MMP3
25colon cancer30.2TLR9, CXCL1, MMP3
26vascular disease30.2APOH, HP, IL1RN, MMP3
27primary biliary cirrhosis30.2TLR9, HLA-DRB1, IL2RB
28sarcoidosis30.2SERPINA3, IL2RB, IL1RAPL2, IL1RN, IL12B, HLA-DRB1
29ankylosing spondylitis30.2CRP, HP, IL1RN, IL1R1, IL1RAPL2, MMP3
30antiphospholipid syndrome30.2APOH
31breast cancer30.2CCL5, TLR9, CXCL1, IL1R1, IL1RAPL2, MMP3
32ulcerative colitis30.2TLR9, HLA-DRB1, CRP, CXCL1, IL12B, IL1RN
33atherosclerosis30.2HP, CRP, APOH, TLR9, CCL5, CXCL1
34temporal arteritis11.1
35bursitis10.6
36rhizomelic pseudopolyarthritis10.5
37cellulitis10.4
38cervicitis10.4
39prostatitis10.4
40spondylitis10.4
41spondyloarthropathy10.4
42acute myeloid leukemia10.3
43aortitis10.3
44miliary tuberculosis10.3
45dissecting aortic aneurysm10.3
46acute leukemia10.3
47osteoporosis10.3
48endocarditis10.3
49giant cell tumor10.3
50myeloid leukemia10.3

Graphical network of the top 20 diseases related to Polymyalgia Rheumatica:



Diseases related to polymyalgia rheumatica

Clinical Features for Polymyalgia Rheumatica

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Drugs & Therapeutics for Polymyalgia Rheumatica

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Polymyalgia Rheumatica

Drug clinical trials:

Search ClinicalTrials for Polymyalgia Rheumatica

Search NIH Clinical Center for Polymyalgia Rheumatica

Search CenterWatch for Polymyalgia Rheumatica

Genetic Tests for Polymyalgia Rheumatica

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Anatomical Context for Polymyalgia Rheumatica

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32MalaCards
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MalaCards organs/tissues related to Polymyalgia Rheumatica:

32
Testes, Skin, Bone, Pituitary, T cells, Prostate, Colon, Endothelial, B cells, Myeloid, Skeletal muscle, Monocytes, Kidney, Breast, Adrenal gland

Animal Models for Polymyalgia Rheumatica or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polymyalgia Rheumatica:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.4MMP3, TLR9, CRP, HP, IL12B, IL12A

Publications for Polymyalgia Rheumatica

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50PubMed
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Articles related to Polymyalgia Rheumatica:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Polymyalgia rheumatica: diagnosis, prescribing, and monitoring in general practice. (23643235)
2013
2
Pleural and pericardial effusion in a patient with polymyalgia rheumatica: a case presentation. (23453662)
2013
3
Phagocyte dysfunction in polymyalgia rheumatica and other age-related, chronic, inflammatory conditions. (23904438)
2013
4
A case of apoplectic lymphocytic hypophysitis complicated by polymyalgia rheumatica. (20514486)
2013
5
Effective control of polymyalgia rheumatica with tocilizumab. (24048113)
2013
6
Update on polymyalgia rheumatica. (23579169)
2013
7
Patient-reported outcomes in polymyalgia rheumatica. (22422492)
2012
8
Altered mental status in an elderly woman with concurrent takotsubo syndrome and polymyalgia rheumatica: a case of treatable geriatric delirium. (22529762)
2012
9
Association of ferritin autoantibodies with giant cell arteritis/polymyalgia rheumatica. (22228484)
2012
10
Anterior uveitis as an initial manifestation of polymyalgia rheumatica. (21629812)
2011
11
Elevated muscle interstitial levels of pain-inducing substances in symptomatic muscles in patients with polymyalgia rheumatica. (21388741)
2011
12
Similar effects of leucine rich and regular dairy products on muscle mass and functions of older polymyalgia rheumatica patients: a randomized crossover trial. (21623468)
2011
13
Phaeohyphomycosis caused by Exophiala jeanselmei in a patient with polymyalgia rheumatica. (20507409)
2010
14
Predictors of positive temporal artery biopsy in patients with giant cell arteritis and polymyalgia rheumatica (comment on the article by MarA- et al.). (20122617)
2010
15
Polymyalgia rheumatica. (21413499)
2010
16
A case of recurrent polymyalgia rheumatica-like complications with pregnancy. (19466422)
2010
17
Clinical, radiological, and biochemical characteristics in patients with diseases mimicking polymyalgia rheumatica. (19851514)
2009
18
F-18 FDG PET/CT of polymyalgia rheumatica. (19387211)
2009
19
Aseptic spondylodiscitis in a patient with polymyalgia rheumatica. (21709837)
2009
20
Interleukin-12 gene polymorphisim in patients with giant cell arteritis, polymyalgia rheumatica and elderly-onset rheumatoid arthritis. (19646340)
2009
21
Pericardial tamponade in a patient with polymyalgia rheumatica. (19646352)
2009
22
Serum interleukin-6 receptor in polymyalgia rheumatica: a potential marker of relapse/recurrence risk. (18668607)
2008
23
Polymyalgia rheumatica and giant-cell arteritis. (18640460)
2008
24
Polymyalgia rheumatica: clinical picture and principles of treatment. (18619195)
2008
25
Analysis of peripheral blood lymphocytes using flow cytometry in polymyalgia rheumatica, RS3PE and early rheumatoid arthritis. (19210873)
2008
26
Polymyalgia rheumatica in a renal transplant patient. (19006913)
2008
27
Development of ischemic complications in patients with giant cell arteritis presenting with apparently isolated polymyalgia rheumatica: study of a series of 100 patients. (17632265)
2007
28
Infliximab plus prednisone or placebo plus prednisone for the initial treatment of polymyalgia rheumatica: a randomized trial. (17470831)
2007
29
Acute dissecting thoracic aortic aneurysm in a patient with polymyalgia rheumatica. (18004093)
2007
30
Rising erythrocyte sedimentation rate in a patient with treated polymyalgia rheumatica: colon cancer as an accidental association versus paraneoplastic syndrome. (16601549)
2006
31
Polymyalgia rheumatica in primary SjAPgren's syndrome. (15988601)
2006
32
Polymyalgia rheumatica and breast cancer. (16891926)
2006
33
Magnetic resonance imaging in the differential diagnosis between polymyalgia rheumatica and elderly onset rheumatoid arthritis. (16220228)
2006
34
Serum amyloid A as a useful index of disease activity in polymyalgia rheumatica]. (12910963)
2003
35
Polymyalgia rheumatica and temporal arteritis: evidence and guidelines for diagnosis and management in older people. (12851178)
2003
36
A fresh look at polymyalgia rheumatica. (12468832)
2002
37
Polymyalgia rheumatica and giant cell arteritis. Avoiding management traps. (11558196)
2001
38
Assessment and management of polymyalgia rheumatica in older adults. (11410767)
2001
39
Polymyalgia rheumatica and temporal arteritis with sacroiliitis and osteitis pubis. (17039146)
2001
40
Epidemiology of polymyalgia rheumatica. (10948749)
2000
41
Polymyalgia rheumatica with low erythrocyte sedimentation rate. (10990253)
2000
42
Lack of association between infection and onset of polymyalgia rheumatica. (10782822)
2000
43
Giant cell arteritis and polymyalgia rheumatica: are pregnancies a protective factor? A prospective, multicentre case-control study. GRACG (Groupe de Recherche sur l'ArtAcrite A Cellules GAcantes). (10342623)
1999
44
Polymyalgia rheumatica with low erythrocyte sedimentation rate at diagnosis. (10381052)
1999
45
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Oral prednisolone 40 mg daily is not adequate for temporal arteritis once vision is affected. (9329327)
1997
46
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Urgency in giving steroids in giant cell arteritis is still not widely appreciated. (9329328)
1997
47
Antibodies to cardiolipin and beta 2 glycoprotein I in patients with polymyalgia rheumatica and giant cell arteritis. (8738442)
1996
48
Non-giant cell arteritis of the temporal artery presenting as the polymyalgia rheumatica-temporal arteritis syndrome. (8596167)
1995
49
Subclavian and axillary involvement in temporal arteritis and polymyalgia rheumatica. (2294760)
1990
50
Giant cell arteritis, temporal arteritis, and polymyalgia rheumatica in a Danish county. A prospective investigation, 1982-1985. (3566821)
1987

Genetic Variations for Polymyalgia Rheumatica

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Expression for genes affiliated with Polymyalgia Rheumatica

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polymyalgia Rheumatica

Search GEO for disease gene expression data for Polymyalgia Rheumatica.

Pathways for genes affiliated with Polymyalgia Rheumatica

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Sources:
29KEGG, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome
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Pathways related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2TLR9, KLRB1
2
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10.2IL12A, CXCL1
3
Development Thrombopoetin signaling via JAK-STAT pathway
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10.2CRP, IL1RN, SERPINA3
410.1TLR9, IL12B, IL12A
5
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10.1TLR9, IL12B, IL12A
6
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10.1IL1R1, IL12B, TLR9
710.1IL12B, CXCL1, HLA-DRB1
810.1CXCL1, IL12B, IL12A
910.1IL2RB, IL12A, IL12B, HLA-DRB1
10
Hide members
10.0TLR9, HLA-DRB1, IL1R1, IL2RB
1110.0TLR9, HLA-DRB1, IL12B, IL12A
12
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10.0CCL5, TLR9, IL12B, IL12A
13
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10.0IL1R1, IL12A, IL12B, TLR9
14
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10.0IL2RB, IL12A, IL12B, CXCL1
1510.0CXCL1, IL12B, IL12A, IL1R1
16
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10.0HLA-DRB1, IL1RN, IL1R1, IL2RB, MX1
17
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9.9HLA-DRB1, IL12B, IL12A, IL1R1, IL2RB
18
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9.9CCL5, IL12B, IL12A, IL1R1, IL2RB
19
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9.8TLR9, HLA-DRB1, IL1RN, IL1R1, IL2RB, MX1
20
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9.8CCL5, CXCL1, IL12B, IL12A, IL1R1, IL2RB
21
Hide members
9.7MX1, IL2RB, IL12A, IL12B, HLA-DRB1, TLR9
22
Hide members
9.7CCL5, TLR9, CXCL1, IL12B, IL12A, IL1R1

Compounds for genes affiliated with Polymyalgia Rheumatica

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6APOH
2endotoxin4410.6CXCL1, APOH
3cycloheximide4410.6IL2RB, MX1, IL1RAPL2
4anakinra44 1111.3IL1RAPL2, IL1R1, IL1RN, CRP
5amphotericin b4410.3IL1RN, IL1R1, IL1RAPL2, CCL5, CRP
6pentoxifylline44 1111.3IL1RN, IL1RAPL2, IL1R1, IL12B, IL2RB
7polysulfone4410.3IL2RB, IL1R1, IL1RN, CRP, IL1RAPL2
8adalimumab44 49 1112.3IL1RAPL2, IL1RN, CRP, IL1R1, MMP3
9rantes4410.3IL2RB, CXCL1, IL1R1, IL12B, IL1RAPL2
10hydroxychloroquine44 1111.3TLR9, APOH, CRP, IL1R1
11leflunomide49 44 1112.2IL1RN, IL1RAPL2, IL2RB, MMP3, IL1R1
12il 104410.2IL1RAPL2, IL1RN, IL12B, CCL5, IL2RB, IL1R1
13lipoteichoic acid4410.2IL1R1, TLR9, IL1RN, IL12B, APOH
14dexamethasone44 49 28 1113.2CXCL1, CCL5, SULT2A1, IL1RAPL2, IL1R1
15ivig4410.2IL2RB, IL1RAPL2, CRP, IL1R1, APOH, IL1RN
16prednisolone44 28 1112.2MMP3, APOH, CRP, IL1R1, IL1RAPL2, IL2RB
17neopterin4410.1CRP, HP, IL2RB, IL1RAPL2, IL1R1, IL1RN
18peptidoglycan44 2811.1IL1R1, IL1RN, TLR9, CCL5, IL12B
19etanercept44 49 1112.1IL1R1, IL1RN, MMP3, IL2RB, IL1RAPL2, APOH
20cuprophan4410.1IL1RAPL2, IL2RB, IL1RN, IL1R1
21leukotriene b444 59 2412.1CXCL1, IL2RB, IL1RAPL2, IL1R1, IL1RN, CCL5
22cyclosporin a44 28 5912.1IL1R1, HP, CCL5, IL2RB, IL1RAPL2, CXCL1
23aspirin44 49 28 2413.0IL2RB, APOH, IL1RAPL2, IL1R1, CRP, CCL5
24nacl4410.0SERPINA3, IL1R1, IL1RAPL2, MMP3, SULT2A1, CCL5
25sulfasalazine44 28 49 1113.0IL12B, MMP3, IL1RAPL2, IL1R1, IL1RN, CRP
26infliximab44 49 1112.0IL1R1, IL1RN, IL2RB, CXCL1, CRP, APOH
27methionine449.9SERPINA3, IL1RAPL2, MMP3, HP, IL2RB, IL1R1
28ribonucleic acid449.9MMP3, IL2RB, IL1RAPL2, IL1R1, IL1RN, CCL5
29polyethylene glycol449.9IL1RN, IL1RAPL2, HP, CRP, IL1R1
30acth449.9IL2RB, HP, IL1RN, IL1R1, IL1RAPL2, SULT2A1
31sb 20358044 5910.9MMP3, IL1R1, IL1RN, CCL5, CRP, IL12B
32vitamin d449.9CCL5, IL1R1, MMP3, SULT2A1, IL12B, HP
33iron44 2410.9IL1R1, IL1RAPL2, IL2RB, MMP3, SERPINA3, APOH
34fibrinogen449.9IL1RN, APOH, CRP, SERPINA3, HP, IL1RAPL2
35lactate449.9CCL5, MMP3, IL1R1, IL1RN, HP, CRP
36polyacrylamide449.8APOH, HP, IL12B, IL1RN, SULT2A1, SERPINA3
37creatinine449.8CCL5, APOH, IL1RN, CRP, IL2RB, IL1R1
38alanine449.8CCL5, HLA-DRB1, HP, IL1RN, IL1R1, IL2RB
39heparin44 28 11 2412.8SERPINA3, MMP3, APOH, HP, IL1RAPL2, IL1R1
40progesterone44 59 28 11 2413.8MMP3, APOH, IL1RN, SERPINA3, HP, CXCL1
41cholesterol44 28 11 2412.7SULT2A1, IL1RAPL2, IL1R1, MMP3, IL2RB, IL1RN
42vegf449.7IL1RN, HP, CRP, APOH, CCL5, IL1R1
43nitric oxide44 11 2411.6IL1R1, IL1RN, CCL5, IL12B, CXCL1, APOH
44lipid449.6CRP, IL1R1, SULT2A1, SERPINA3, MMP3, CCL5
45methotrexate44 49 1111.5IL1RAPL2, IL1R1, IL1RN, CRP, HLA-DRB1, APOH
46serine449.5HP, IL2RB, IL1RN, IL1R1, CXCL1, IL1RAPL2
47retinoic acid44 2410.3KRT15, MMP3, IL1R1, IL2RB, IL1RAPL2, IL1RN
48tyrosine449.2NM, MMP3, IL2RB, IL1R1, IL1RN, CXCL1
49calcium44 49 11 2412.2MMP3, IL1RAPL2, IL1R1, IL1RN, IL12B, CXCL1
50atp44 2810.1KRT15, MX1, MMP3, IL1RAPL2, IL1RN, HP

GO Terms for genes affiliated with Polymyalgia Rheumatica

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16Gene Ontology
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Cellular components related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 complexGO:04351410.0IL12B, IL12A
2extracellular regionGO:0055769.5SERPINA3, MMP3, IL1R1, CXCL1, HP, CRP
3extracellular spaceGO:0056159.2SERPINA3, CCL5, APOH, CRP, HP, CXCL1

Biological processes related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.5IL12B, IL12A
2positive regulation of NK T cell activationGO:05113510.5IL12B, IL12A
3positive regulation of lymphocyte proliferationGO:05067110.5IL12B, IL12A
4maintenance of gastrointestinal epitheliumGO:03027710.5TLR9, SERPINA3
5positive regulation of cell adhesionGO:04578510.4CCL5, IL12B, IL12A
6positive regulation of activation of JAK2 kinase activityGO:01053510.4CCL5, IL12B
7positive regulation of T cell proliferationGO:04210210.4IL12A, IL12B, CCL5
8acute-phase responseGO:00695310.4SERPINA3, IL1RN, HP, CRP
9positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.4IL12B, IL12A
10positive regulation of smooth muscle cell apoptotic processGO:03439310.4IL12B, IL12A
11positive regulation of natural killer cell activationGO:03281610.3IL12B, IL12A
12T-helper 1 type immune responseGO:04208810.3IL12B, HLA-DRB1
13negative regulation of interleukin-17 productionGO:03270010.3IL12A, IL12B
14inflammatory responseGO:00695410.2CCL5, TLR9, CRP, CXCL1, SERPINA3
15immune responseGO:00695510.2IL1R1, IL1RN, IL12A, CXCL1, HLA-DRB1
16response to UV-BGO:01022410.2IL12B, IL12A
17positive regulation of interferon-gamma biosynthetic processGO:0450789.9IL12B, TLR9

Molecular functions related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.3IL1RN, TLR9
2interleukin-12 receptor bindingGO:00514310.2IL12A, IL12B
3interleukin-1 receptor activityGO:0049089.9IL1RAPL2, IL1R1

Products for genes affiliated with Polymyalgia Rheumatica

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  • Antibodies
  • Proteins
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Sources for Polymyalgia Rheumatica

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet