MCID: PLY013
MIFTS: 53

Polymyalgia Rheumatica malady

Bone diseases, Rare diseases, Muscle diseases categories
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Summaries for Polymyalgia Rheumatica

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MedlinePlus:33 Polymyalgia rheumatica is a disorder that causes muscle pain and stiffness in your neck, shoulders, and hips. it is most common in women and almost always occurs in people over 50. the main symptom is stiffness after resting. other symptoms include fever, weakness and weight loss. in some cases, polymyalgia rheumatica develops overnight. in others, it is gradual. the cause is not known. there is no single test to diagnose polymyalgia rheumatica. your doctor will use your medical history, symptoms, and a physical exam to make the diagnosis. lab tests for inflammation may help confirm the diagnosis. polymyalgia rheumatica sometimes occurs along with giant cell arteritis, a condition that causes swelling of the arteries in your head. symptoms include headaches and blurred vision. doctors often prescribe prednisone, a steroid medicine, for both conditions. with treatment, polymyalgia rheumatica usually disappears in a day or two. without treatment, it usually goes away after a year or more. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Polymyalgia Rheumatica, also known as rhizomelic pseudopolyarthritis, is related to synovitis and amyloidosis. An important gene associated with Polymyalgia Rheumatica is IL1RN (interleukin 1 receptor antagonist), and among its related pathways are Signaling by Interleukins and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds gold sodium thiomalate and cuprophan have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone, and related mouse phenotype immune system.

Wikipedia:65 Polymyalgia rheumatica (which takes its name from the word ??????????? \"polymyalgia\" which means... more...

Aliases & Classifications for Polymyalgia Rheumatica

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Sources:
8Disease Ontology, 44Novoseek, 48Orphanet, 33MedlinePlus, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 63UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Polymyalgia Rheumatica, Aliases & Descriptions:

Name: Polymyalgia Rheumatica 8 44 48 33 62
 
Rhizomelic Pseudopolyarthritis 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Muscle diseases


External Ids:

Disease Ontology8 DOID:853
ICD9CM27 725
MeSH34 D011111
NCIt39 C85018
UMLS via Orphanet63 C1527406
ICD10 via Orphanet26 M35.3
ICD1025 M35.3

Related Diseases for Polymyalgia Rheumatica

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Diseases related to Polymyalgia Rheumatica via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1synovitis31.3CRP, IL1RN
2amyloidosis30.8CRP, SERPINA3
3hepatitis30.8HLA-DRB1, IL2RB
4bronchiolitis30.7CCL5
5myositis30.7IL1RN, SERPINA3
6ankylosing spondylitis30.6CRP, IL1RN
7arthropathy30.6CRP, IL1RN
8primary biliary cirrhosis30.5HLA-DRB1, IL2RB
9pneumonia30.5CRP, IL2RB, CCL5
10septic shock30.4CRP, IL1RN
11arthritis30.4HLA-DRB1, SERPINA3, CCL5, IL2RB, IL1RN, CRP
12rheumatoid arthritis30.3HLA-DRB1, SERPINA3, CCL5, IL2RB, IL1RN, CRP
13ulcerative colitis30.3HLA-DRB1, IL1RN, CRP
14myocardial infarction30.0SERPINA3, CCL5, CRP
15atherosclerosis30.0CRP, IL1RN, CCL5
16sarcoidosis29.6HLA-DRB1, SERPINA3, CCL5, IL2RB, IL1RN
17temporal arteritis11.1
18vasculitis10.8
19bursitis10.7
20rhizomelic pseudopolyarthritis10.6
21influenza10.6
22blindness10.5
23hyper-igd syndrome10.5IL1RN
24schnitzler syndrome10.5IL1RN
25dengue shock syndrome10.5IL1RN
26malignant histiocytosis10.5SERPINA3
27emphysema due to aat deficiency10.4SERPINA3
28aortic aneurysm10.4
29cellulitis10.4
30cervicitis10.4
31prostatitis10.4
32spondylitis10.4
33spondyloarthropathy10.4
34aneurysm10.4
35adult-onset still's disease10.4CRP
36skin disease10.4HLA-DRB1
37carotid stenosis10.4CRP
38diabetes mellitus10.3
39osteoporosis10.3
40prostate cancer10.3
41aortitis10.3
42miliary tuberculosis10.3
43endocarditis10.3
44meningitis10.3
45pericardial effusion10.3
46tuberculosis10.3
47juvenile temporal arteritis10.3
48endotheliitis10.3
49acute graft versus host disease10.3IL1RN, IL2RB
50meningococcemia10.3CCL5

Graphical network of the top 20 diseases related to Polymyalgia Rheumatica:



Diseases related to polymyalgia rheumatica

Symptoms for Polymyalgia Rheumatica

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Drugs & Therapeutics for Polymyalgia Rheumatica

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Drug clinical trials:

Search ClinicalTrials for Polymyalgia Rheumatica

Search NIH Clinical Center for Polymyalgia Rheumatica

Genetic Tests for Polymyalgia Rheumatica

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Anatomical Context for Polymyalgia Rheumatica

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MalaCards organs/tissues related to Polymyalgia Rheumatica:

32
Testes, Skin, Bone, Pituitary, T cells, Colon, Prostate, Skeletal muscle, B cells, Endothelial, Kidney, Adrenal gland, Breast, Myeloid, Monocytes, Neutrophil

Animal Models for Polymyalgia Rheumatica or affiliated genes

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MGI Mouse Phenotypes related to Polymyalgia Rheumatica:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.7CRP, IL1RN, IL2RB, IL12A, CCL5

Publications for Polymyalgia Rheumatica

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Articles related to Polymyalgia Rheumatica:

(show top 50)    (show all 574)
idTitleAuthorsYear
1
Influence of interleukin 10 promoter polymorphisms in polymyalgia rheumatica: disease susceptibility and functional consequences. (24983912)
2014
2
14. A double-blind, randomized, placebo-controlled pilot study of leflunomide in polymyalgia rheumatica. (25079166)
2014
3
Giant cell arteritis and polymyalgia rheumatica after reexposure to a statin: a case report. (25329212)
2014
4
ARDS with septic shock due to Legionella longbeachae pneumonia in a patient with polymyalgia rheumatica. (25024993)
2014
5
Polymyalgia rheumatica. (24301266)
2013
6
Polymyalgia rheumatica and giant cell arteritis. (24364492)
2013
7
2012 Provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. (22389040)
2012
8
Addison's disease masked by long-term exogenous steroid treatment for presumed polymyalgia rheumatica. (22372233)
2012
9
Provisional diagnostic criteria for polymyalgia rheumatica: moving beyond clinical intuition? (22388994)
2012
10
Response to 'Effect of etanercept in polymyalgia rheumatica: a randomized controlled trial'. (21542877)
2011
11
Ultrasonographic monitoring of response to therapy in polymyalgia rheumatica. (19773289)
2010
12
Concise guidance: diagnosis and management of polymyalgia rheumatica. (20726461)
2010
13
Can the prognosis of polymyalgia rheumatica be predicted at disease onset? Results from a 5-year prospective study. (20064872)
2010
14
Presentations of perforated colonic pathology in patients with polymyalgia rheumatica: two case reports. (20819228)
2010
15
A case of cold agglutinin disease in the course of treatment for polymyalgia rheumatica. (19340395)
2009
16
Serum interleukin-6 receptor in polymyalgia rheumatica: a potential marker of relapse/recurrence risk. (18668607)
2008
17
The clinical implication of cervical interspinous bursitis in the diagnosis of polymyalgia rheumatica. (18474656)
2008
18
Small-vessel vasculitis surrounding an uninflamed temporal artery: a new diagnostic criterion for polymyalgia rheumatica? (18668584)
2008
19
Repetitive 18-fluorodeoxyglucose positron emission tomography in isolated polymyalgia rheumatica: a prospective study in 35 patients. (17114803)
2007
20
Unilateral polymyalgia rheumatica with controlateral sympathetic dystrophy syndrome. A case of asymmetrical involvement due to pre-existing peripheral palsy. (17085469)
2006
21
Synovial expression of vasoactive intestinal peptide in polymyalgia rheumatica. (17181926)
2006
22
Polymyalgia rheumatica: diagnosis and treatment. (17113808)
2006
23
Do steroids increase lymphoma risk? A case-control study of lymphoma risk in polymyalgia rheumatica/giant cell arteritis. (15843445)
2005
24
Calcium pyrophosphate deposition disease mimicking polymyalgia rheumatica: a prospective followup study of predictive factors for this condition in patients presenting with polymyalgia symptoms. (16342107)
2005
25
Crowned dens syndrome misdiagnosed as polymyalgia rheumatica, giant cell arteritis, meningitis or spondylitis: an analysis of eight cases. (15316123)
2004
26
Giant-cell arteritis and polymyalgia rheumatica. (13679329)
2003
27
Genetic markers of disease susceptibility and severity in giant cell arteritis and polymyalgia rheumatica. (12920695)
2003
28
Polymyalgia rheumatica and giant-cell arteritis. (12494941)
2002
29
Sex differences in temporal arteritis and polymyalgia rheumatica. (11838850)
2002
30
Ultrasonography of temporal arteries discloses temporal arteritis in "pure" polymyalgia rheumatica patients. (12532975)
2002
31
Polymyalgia rheumatica revisited. (11591045)
2001
32
Polymyalgia rheumatica: pitfalls in diagnosis. (11385095)
2001
33
Polymyalgia rheumatica and giant cell arteritis. Avoiding management traps. (11558196)
2001
34
Polymyalgia rheumatica: evidence for a hypothalamic-pituitary-adrenal axis-driven disease. (11138324)
2000
35
Epidemiology of polymyalgia rheumatica. (10948749)
2000
36
Polymyalgia rheumatica and temporal arthritis. (10969858)
2000
37
Management of giant cell arteritis and polymyalgia rheumatica. (10779249)
2000
38
The spectrum of polymyalgia rheumatica in northwestern Spain: incidence and analysis of variables associated with relapse in a 10 year study. (10381051)
1999
39
Distribution of HLA-DRB1 alleles of patients with polymyalgia rheumatica and giant cell arteritis in a Mediterranean population. (9458210)
1998
40
Effects of glucocorticoids on bone mass in patients with polymyalgia rheumatica. A longitudinal study. (9779318)
1998
41
Elevated serum concentrations of the chemokine RANTES in patients with polymyalgia rheumatica. (9631747)
1998
42
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Patients starting steroids should be given advice on risk of osteoporosis. (9329330)
1997
43
Spondyloarthropathy presenting as a polymyalgia rheumatica-like syndrome. (9456015)
1997
44
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Sensitivity of temporal artery biopsy varies with biopsy length and sectioning strategy. (9329326)
1997
45
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Oral prednisolone 40 mg daily is not adequate for temporal arteritis once vision is affected. (9329327)
1997
46
A randomized controlled trial of salmon calcitonin to prevent bone loss in corticosteroid-treated temporal arteritis and polymyalgia rheumatica. (8998681)
1996
47
Non-giant cell arteritis of the temporal artery presenting as the polymyalgia rheumatica-temporal arteritis syndrome. (8596167)
1995
48
Subclavian and axillary involvement in temporal arteritis and polymyalgia rheumatica. (2294760)
1990
49
Temporal arteritis after normalization of erythrocyte sedimentation rate in polymyalgia rheumatica. (3778060)
1986
50
Granulomatous angiitis presenting with polymyalgia rheumatica and abnormal pituitary function. (3966760)
1985

Variations for Polymyalgia Rheumatica

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Expression for genes affiliated with Polymyalgia Rheumatica

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Expression patterns in normal tissues for genes affiliated with Polymyalgia Rheumatica

Search GEO for disease gene expression data for Polymyalgia Rheumatica.

Pathways for genes affiliated with Polymyalgia Rheumatica

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Pathways related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7IL1RN, IL2RB
2
Show member pathways
9.5IL12A, IL2RB
3
Show member pathways
thioredoxin pathway37
9.4SERPINA3, CRP
4
Show member pathways
9.2IL1RN, IL2RB, HLA-DRB1
59.1CCL5, HLA-DRB1
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.0CRP, IL1RN, SERPINA3
7
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.0HLA-DRB1, IL12A, IL2RB
8
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.0IL2RB, IL12A, HLA-DRB1
9
Show member pathways
8.7IL2RB, IL12A, CCL5
10
Show member pathways
8.7CCL5, IL12A, IL2RB
11
Show member pathways
8.7IL2RB, IL12A, CCL5
12
Show member pathways
8.7CCL5, IL12A, IL2RB
13
Show member pathways
8.2IL2RB, IL12A, CCL5, HLA-DRB1

Compounds for genes affiliated with Polymyalgia Rheumatica

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Compounds related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1gold sodium thiomalate449.9IL1RN, HLA-DRB1
2cuprophan449.9IL2RB, IL1RN
3anakinra44 1110.9IL1RN, CRP
4adalimumab44 50 1111.8CRP, IL1RN
5polysulfone449.5IL1RN, IL2RB, CRP
6etanercept44 50 1111.5IL2RB, IL1RN, CRP
7infliximab44 50 1111.5IL2RB, IL1RN, CRP
8ivig449.5CRP, IL1RN, IL2RB
9neopterin449.5CRP, IL1RN, IL2RB
10glatiramer acetate44 1110.5HLA-DRB1, CCL5
11bryostatin 1449.5CCL5, IL2RB
12p003449.5CRP, IL2RB, IL1RN
13prednisolone44 28 1111.5CRP, IL1RN, IL2RB
14methionine449.4IL1RN, SERPINA3, IL2RB
15vitamin a44 24 1111.3SERPINA3, IL1RN, CRP
16pmma449.3CRP, CCL5
17il 10449.3IL1RN, IL2RB, CCL5
18leukotriene b444 61 2411.3CCL5, IL1RN, IL2RB
19mycophenolic acid44 50 1111.2IL2RB, CCL5
20fmlp449.2CCL5, IL1RN, SERPINA3
21rantes449.2IL2RB, CCL5, IL1RN
22nacl449.2SERPINA3, IL1RN, CCL5
23ribonucleic acid449.2IL2RB, IL1RN, CCL5
24ionomycin449.2CCL5, IL2RB, SERPINA3
25amphotericin b449.1CCL5, IL1RN, CRP
26methacholine44 50 1111.0CRP, IL2RB, CCL5
27simvastatin44 50 61 28 24 1114.0IL1RN, CRP, CCL5
28iron44 2410.0IL1RN, CRP, SERPINA3, IL2RB
29azathioprine44 2 50 1112.0CRP, CCL5, IL2RB
30folate448.9CRP, SERPINA3, CCL5
31fibrinogen448.9IL1RN, CRP, SERPINA3
32sb 20358044 619.9CRP, IL1RN, CCL5
33n acetylcysteine448.9CRP, IL2RB, CCL5
34histamine44 28 2410.9CCL5, IL2RB, IL1RN
35norepinephrine44 24 1110.8IL1RN, IL2RB, CRP
36dexamethasone44 50 28 1111.8CCL5, IL2RB, IL1RN, SERPINA3
37zinc44 249.7IL1RN, SERPINA3, IL2RB, CCL5
38endotoxin448.7CRP, IL2RB, CCL5, IL1RN
39aspirin44 50 28 2411.7IL2RB, CCL5, IL1RN, CRP
40lactate448.7IL1RN, CRP, IL2RB, CCL5
41cycloheximide448.6CCL5, IL1RN, CRP, IL2RB
42retinoic acid44 249.6IL1RN, IL2RB, CCL5, SERPINA3
43vegf448.6CCL5, IL2RB, CRP, IL1RN
44creatinine448.2IL1RN, CRP, IL2RB, SERPINA3, CCL5
45glucose448.2IL2RB, CRP, SERPINA3, CCL5
46cholesterol44 28 24 1111.2IL2RB, CRP, CCL5, IL1RN, SERPINA3
47lipid448.2SERPINA3, CRP, CCL5, IL2RB, IL1RN
48calcium44 50 24 1110.9IL2RB, IL1RN, CCL5, SERPINA3, CRP
49methotrexate50 44 119.7CRP, IL2RB, CCL5, SERPINA3, HLA-DRB1, IL1RN
50alanine447.7IL2RB, HLA-DRB1, SERPINA3, CCL5, IL1RN, CRP

GO Terms for genes affiliated with Polymyalgia Rheumatica

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Cellular components related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1CRP, IL1RN, IL12A, CCL5

Biological processes related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1defense response to Gram-positive bacteriumGO:0508309.4IL12A, CRP
2protein tetramerizationGO:0512629.3CCL5, HLA-DRB1
3acute-phase responseGO:0069539.2CRP, IL1RN, SERPINA3
4positive regulation of cell adhesionGO:0457859.1IL12A, CCL5
5response to virusGO:0096159.1IL12A, CCL5
6immune responseGO:0069559.0HLA-DRB1, IL12A, IL1RN
7positive regulation of T cell proliferationGO:0421028.8IL12A, CCL5
8inflammatory responseGO:0069548.7CRP, CCL5, SERPINA3

Products for genes affiliated with Polymyalgia Rheumatica

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Sources for Polymyalgia Rheumatica

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet