MCID: PLY013
MIFTS: 52

Polymyalgia Rheumatica malady

Bone diseases, Rare diseases, Muscle diseases categories

Summaries for Polymyalgia Rheumatica

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35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Polymyalgia rheumatica is a disorder that causes muscle pain and stiffness in your neck, shoulders, and hips. it is most common in women and almost always occurs in people over 50. the main symptom is stiffness after resting. other symptoms include fever, weakness and weight loss. in some cases, polymyalgia rheumatica develops overnight. in others, it is gradual. the cause is not known. there is no single test to diagnose polymyalgia rheumatica. your doctor will use your medical history, symptoms, and a physical exam to make the diagnosis. lab tests for inflammation may help confirm the diagnosis. polymyalgia rheumatica sometimes occurs along with giant cell arteritis, a condition that causes swelling of the arteries in your head. symptoms include headaches and blurred vision. doctors often prescribe prednisone, a steroid medicine, for both conditions. with treatment, polymyalgia rheumatica usually disappears in a day or two. without treatment, it usually goes away after a year or more. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Polymyalgia Rheumatica, also known as rhizomelic pseudopolyarthritis, is related to arthritis and rheumatoid arthritis. An important gene associated with Polymyalgia Rheumatica is IL1RN (interleukin 1 receptor antagonist), and among its related pathways are Signaling by Interleukins and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds gold sodium thiomalate and cuprophan have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related mouse phenotype immune system.

Wikipedia:66 Polymyalgia rheumatica (which takes its name from the word ??????????? \"polymyalgia\" which means... more...

Aliases & Classifications for Polymyalgia Rheumatica

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9Disease Ontology, 46Novoseek, 50Orphanet, 35MedlinePlus, 59SNOMED-CT, 28ICD9CM, 41NCIt, 36MeSH, 63UMLS, 64UMLS via Orphanet, 27ICD10 via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Muscle diseases


Aliases & Descriptions:

polymyalgia rheumatica 9 46 50 35
rhizomelic pseudopolyarthritis 50


External Ids:

Disease Ontology9 DOID:853
ICD9CM28 725
NCIt41 C85018
MeSH36 D011111
UMLS via Orphanet64 C1527406
ICD10 via Orphanet27 M35.3
ICD1026 M35.3

Related Diseases for Polymyalgia Rheumatica

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Polymyalgia Rheumatica via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.2HLA-DRB1, SERPINA3, CCL5, IL2RB, IL1RN, CRP
2rheumatoid arthritis31.1HLA-DRB1, SERPINA3, CCL5, IL2RB, IL1RN, CRP
3synovitis31.1CRP, IL1RN
4amyloidosis30.7CRP, SERPINA3
5pneumonia30.6CRP, IL2RB, CCL5
6hepatitis30.6HLA-DRB1, IL2RB
7bronchiolitis30.4CCL5
8myositis30.4IL1RN, SERPINA3
9ankylosing spondylitis30.3CRP, IL1RN
10arthropathy30.3CRP, IL1RN
11primary biliary cirrhosis30.3HLA-DRB1, IL2RB
12ulcerative colitis30.3HLA-DRB1, IL1RN, CRP
13myocardial infarction30.2SERPINA3, CCL5, CRP
14atherosclerosis30.2CRP, IL1RN, CCL5
15sarcoidosis30.1HLA-DRB1, SERPINA3, CCL5, IL2RB, IL1RN
16temporal arteritis11.1
17vasculitis10.7
18bursitis10.6
19rhizomelic pseudopolyarthritis10.6
20influenza10.6
21aortic aneurysm10.4
22cellulitis10.4
23cervicitis10.4
24prostatitis10.4
25spondylitis10.4
26spondyloarthropathy10.4
27aneurysm10.4
28blindness10.4
29aortitis10.3
30miliary tuberculosis10.3
31acute myeloid leukemia10.3
32endocarditis10.3
33leukemia10.3
34meningitis10.3
35myeloid leukemia10.3
36osteoporosis10.3
37pericardial effusion10.3
38prostate cancer10.3
39tuberculosis10.3
40endotheliitis10.3
41granulomatous angiitis10.2
42parathyroid carcinoma10.2
43bronchiolitis obliterans10.2
44bronchiolitis obliterans organizing pneumonia10.2
45peripheral artery disease10.2
46takayasu's arteritis10.2
47polyarteritis nodosa10.2
48septic arthritis10.2
49subacute bacterial endocarditis10.2
50addison's disease10.2

Graphical network of the top 20 diseases related to Polymyalgia Rheumatica:



Diseases related to polymyalgia rheumatica

Symptoms for Polymyalgia Rheumatica

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Drugs & Therapeutics for Polymyalgia Rheumatica

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Polymyalgia Rheumatica

Drug clinical trials:

Search ClinicalTrials for Polymyalgia Rheumatica

Search NIH Clinical Center for Polymyalgia Rheumatica

Search CenterWatch for Polymyalgia Rheumatica

Genetic Tests for Polymyalgia Rheumatica

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Anatomical Context for Polymyalgia Rheumatica

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Sources:
34MalaCards
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MalaCards organs/tissues related to Polymyalgia Rheumatica:

34
Skin, Testes, Bone, Pituitary, T cells, Colon, Prostate, Endothelial, B cells, Skeletal muscle, Myeloid, Monocytes, Kidney, Adrenal gland, Breast

Animal Models for Polymyalgia Rheumatica or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Polymyalgia Rheumatica:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.7CRP, IL1RN, IL2RB, IL12A, CCL5

Publications for Polymyalgia Rheumatica

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Sources:
53PubMed
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Articles related to Polymyalgia Rheumatica:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Polymyalgia rheumatica. (24301266)
2013
2
Polymyalgia rheumatica and giant cell arteritis. (24364492)
2013
3
2012 Provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. (22389040)
2012
4
Addison's disease masked by long-term exogenous steroid treatment for presumed polymyalgia rheumatica. (22372233)
2012
5
Provisional diagnostic criteria for polymyalgia rheumatica: moving beyond clinical intuition? (22388994)
2012
6
A case of diffuse endocapillary proliferative glomerulonephritis associated with polymyalgia rheumatica. (23326256)
2012
7
Response to 'Effect of etanercept in polymyalgia rheumatica: a randomized controlled trial'. (21542877)
2011
8
Ultrasonographic monitoring of response to therapy in polymyalgia rheumatica. (19773289)
2010
9
Concise guidance: diagnosis and management of polymyalgia rheumatica. (20726461)
2010
10
Can the prognosis of polymyalgia rheumatica be predicted at disease onset? Results from a 5-year prospective study. (20064872)
2010
11
Presentations of perforated colonic pathology in patients with polymyalgia rheumatica: two case reports. (20819228)
2010
12
A case of cold agglutinin disease in the course of treatment for polymyalgia rheumatica. (19340395)
2009
13
Serum interleukin-6 receptor in polymyalgia rheumatica: a potential marker of relapse/recurrence risk. (18668607)
2008
14
The clinical implication of cervical interspinous bursitis in the diagnosis of polymyalgia rheumatica. (18474656)
2008
15
Small-vessel vasculitis surrounding an uninflamed temporal artery: a new diagnostic criterion for polymyalgia rheumatica? (18668584)
2008
16
Repetitive 18-fluorodeoxyglucose positron emission tomography in isolated polymyalgia rheumatica: a prospective study in 35 patients. (17114803)
2007
17
Unilateral polymyalgia rheumatica with controlateral sympathetic dystrophy syndrome. A case of asymmetrical involvement due to pre-existing peripheral palsy. (17085469)
2006
18
Synovial expression of vasoactive intestinal peptide in polymyalgia rheumatica. (17181926)
2006
19
Polymyalgia rheumatica: diagnosis and treatment. (17113808)
2006
20
Do steroids increase lymphoma risk? A case-control study of lymphoma risk in polymyalgia rheumatica/giant cell arteritis. (15843445)
2005
21
Calcium pyrophosphate deposition disease mimicking polymyalgia rheumatica: a prospective followup study of predictive factors for this condition in patients presenting with polymyalgia symptoms. (16342107)
2005
22
Polymyalgia rheumatica as an unusual cause of pleural and pericardial effusion. (16357699)
2005
23
Crowned dens syndrome misdiagnosed as polymyalgia rheumatica, giant cell arteritis, meningitis or spondylitis: an analysis of eight cases. (15316123)
2004
24
Giant-cell arteritis and polymyalgia rheumatica. (13679329)
2003
25
Genetic markers of disease susceptibility and severity in giant cell arteritis and polymyalgia rheumatica. (12920695)
2003
26
Polymyalgia rheumatica and giant-cell arteritis. (12494941)
2002
27
Sex differences in temporal arteritis and polymyalgia rheumatica. (11838850)
2002
28
Ultrasonography of temporal arteries discloses temporal arteritis in "pure" polymyalgia rheumatica patients. (12532975)
2002
29
Polymyalgia rheumatica revisited. (11591045)
2001
30
Polymyalgia rheumatica: pitfalls in diagnosis. (11385095)
2001
31
Polymyalgia rheumatica and giant cell arteritis. Avoiding management traps. (11558196)
2001
32
Polymyalgia rheumatica as the initial manifestation of skeletal muscle arteritis with giant cells. (11562924)
2001
33
Polymyalgia rheumatica: evidence for a hypothalamic-pituitary-adrenal axis-driven disease. (11138324)
2000
34
Epidemiology of polymyalgia rheumatica. (10948749)
2000
35
Polymyalgia rheumatica and temporal arthritis. (10969858)
2000
36
Management of giant cell arteritis and polymyalgia rheumatica. (10779249)
2000
37
The spectrum of polymyalgia rheumatica in northwestern Spain: incidence and analysis of variables associated with relapse in a 10 year study. (10381051)
1999
38
Distribution of HLA-DRB1 alleles of patients with polymyalgia rheumatica and giant cell arteritis in a Mediterranean population. (9458210)
1998
39
Effects of glucocorticoids on bone mass in patients with polymyalgia rheumatica. A longitudinal study. (9779318)
1998
40
Elevated serum concentrations of the chemokine RANTES in patients with polymyalgia rheumatica. (9631747)
1998
41
Polymyalgia rheumatica in a patient with acute tubulointerstitial nephritis due to SjAPgren's syndrome. (9698029)
1998
42
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Patients starting steroids should be given advice on risk of osteoporosis. (9329330)
1997
43
Spondyloarthropathy presenting as a polymyalgia rheumatica-like syndrome. (9456015)
1997
44
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Sensitivity of temporal artery biopsy varies with biopsy length and sectioning strategy. (9329326)
1997
45
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Oral prednisolone 40 mg daily is not adequate for temporal arteritis once vision is affected. (9329327)
1997
46
A randomized controlled trial of salmon calcitonin to prevent bone loss in corticosteroid-treated temporal arteritis and polymyalgia rheumatica. (8998681)
1996
47
Non-giant cell arteritis of the temporal artery presenting as the polymyalgia rheumatica-temporal arteritis syndrome. (8596167)
1995
48
Subclavian and axillary involvement in temporal arteritis and polymyalgia rheumatica. (2294760)
1990
49
Temporal arteritis after normalization of erythrocyte sedimentation rate in polymyalgia rheumatica. (3778060)
1986
50
Granulomatous angiitis presenting with polymyalgia rheumatica and abnormal pituitary function. (3966760)
1985

Variations for Polymyalgia Rheumatica

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Expression for genes affiliated with Polymyalgia Rheumatica

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polymyalgia Rheumatica

Search GEO for disease gene expression data for Polymyalgia Rheumatica.

Pathways for genes affiliated with Polymyalgia Rheumatica

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Sources:
51PathCards, 56Reactome, 55R&D Systems, 39NCBI BioSystems Database, 31KEGG, 5Cell Signaling Technology, 61Thomson Reuters, 54QIAGEN
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Pathways related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7IL1RN, IL2RB
2
Show member pathways
9.5IL12A, IL2RB
3
Show member pathways
thioredoxin pathway39
9.4SERPINA3, CRP
4
Show member pathways
9.2IL1RN, IL2RB, HLA-DRB1
59.1CCL5, HLA-DRB1
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.0CRP, IL1RN, SERPINA3
7
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.0HLA-DRB1, IL12A, IL2RB
8
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.0IL2RB, IL12A, HLA-DRB1
9
Show member pathways
8.7IL2RB, IL12A, CCL5
10
Show member pathways
8.7CCL5, IL12A, IL2RB
11
Show member pathways
8.7IL2RB, IL12A, CCL5
12
Show member pathways
8.7CCL5, IL12A, IL2RB
13
Show member pathways
8.2IL2RB, IL12A, CCL5, HLA-DRB1

Compounds for genes affiliated with Polymyalgia Rheumatica

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1gold sodium thiomalate469.9IL1RN, HLA-DRB1
2cuprophan469.9IL2RB, IL1RN
3anakinra46 1210.9IL1RN, CRP
4adalimumab46 52 1211.8CRP, IL1RN
5polysulfone469.5IL1RN, IL2RB, CRP
6etanercept46 52 1211.5IL2RB, IL1RN, CRP
7infliximab46 52 1211.5IL2RB, IL1RN, CRP
8ivig469.5CRP, IL1RN, IL2RB
9neopterin469.5CRP, IL1RN, IL2RB
10glatiramer acetate46 1210.5HLA-DRB1, CCL5
11bryostatin 1469.5CCL5, IL2RB
12p003469.5CRP, IL2RB, IL1RN
13prednisolone46 30 1211.5CRP, IL1RN, IL2RB
14methionine469.4IL1RN, SERPINA3, IL2RB
15vitamin a46 25 1211.3SERPINA3, IL1RN, CRP
16pmma469.3CRP, CCL5
17il 10469.3IL1RN, IL2RB, CCL5
18leukotriene b446 62 2511.3CCL5, IL1RN, IL2RB
19mycophenolic acid46 52 1211.2IL2RB, CCL5
20fmlp469.2CCL5, IL1RN, SERPINA3
21rantes469.2IL2RB, CCL5, IL1RN
22nacl469.2SERPINA3, IL1RN, CCL5
23ribonucleic acid469.2IL2RB, IL1RN, CCL5
24ionomycin469.2CCL5, IL2RB, SERPINA3
25amphotericin b469.1CCL5, IL1RN, CRP
26methacholine46 52 1211.0CRP, IL2RB, CCL5
27simvastatin46 52 62 30 25 1214.0IL1RN, CRP, CCL5
28iron46 2510.0IL1RN, CRP, SERPINA3, IL2RB
29azathioprine46 3 52 1212.0CRP, CCL5, IL2RB
30folate468.9CRP, SERPINA3, CCL5
31fibrinogen468.9IL1RN, CRP, SERPINA3
32sb 20358046 629.9CRP, IL1RN, CCL5
33n acetylcysteine468.9CRP, IL2RB, CCL5
34histamine46 30 2510.9CCL5, IL2RB, IL1RN
35norepinephrine46 25 1210.8IL1RN, IL2RB, CRP
36dexamethasone46 52 30 1211.8CCL5, IL2RB, IL1RN, SERPINA3
37zinc46 259.7IL1RN, SERPINA3, IL2RB, CCL5
38endotoxin468.7CRP, IL2RB, CCL5, IL1RN
39aspirin46 52 30 2511.7IL2RB, CCL5, IL1RN, CRP
40lactate468.7IL1RN, CRP, IL2RB, CCL5
41cycloheximide468.6CCL5, IL1RN, CRP, IL2RB
42retinoic acid46 259.6IL1RN, IL2RB, CCL5, SERPINA3
43vegf468.6CCL5, IL2RB, CRP, IL1RN
44creatinine468.2IL1RN, CRP, IL2RB, SERPINA3, CCL5
45glucose468.2IL2RB, CRP, SERPINA3, CCL5
46cholesterol46 30 25 1211.2IL2RB, CRP, CCL5, IL1RN, SERPINA3
47lipid468.2SERPINA3, CRP, CCL5, IL2RB, IL1RN
48calcium46 52 25 1210.9IL2RB, IL1RN, CCL5, SERPINA3, CRP
49methotrexate52 46 129.7CRP, IL2RB, CCL5, SERPINA3, HLA-DRB1, IL1RN
50alanine467.7IL2RB, HLA-DRB1, SERPINA3, CCL5, IL1RN, CRP

GO Terms for genes affiliated with Polymyalgia Rheumatica

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17Gene Ontology
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Cellular components related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1CRP, IL1RN, IL12A, CCL5

Biological processes related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1defense response to Gram-positive bacteriumGO:0508309.4IL12A, CRP
2protein tetramerizationGO:0512629.3CCL5, HLA-DRB1
3acute-phase responseGO:0069539.2CRP, IL1RN, SERPINA3
4positive regulation of cell adhesionGO:0457859.1IL12A, CCL5
5response to virusGO:0096159.1IL12A, CCL5
6immune responseGO:0069559.0HLA-DRB1, IL12A, IL1RN
7positive regulation of T cell proliferationGO:0421028.8IL12A, CCL5
8inflammatory responseGO:0069548.7CRP, CCL5, SERPINA3

Products for genes affiliated with Polymyalgia Rheumatica

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  • Antibodies
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Sources for Polymyalgia Rheumatica

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet