MCID: PLY013
MIFTS: 56

Polymyalgia Rheumatica malady

Bone diseases category

Summaries for Polymyalgia Rheumatica

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Polymyalgia rheumatica is a disorder that causes muscle pain and stiffness in your neck, shoulders, and hips. it is most common in women and almost always occurs in people over 50. the main symptom is stiffness after resting. other symptoms include fever, weakness and weight loss. in some cases, polymyalgia rheumatica develops overnight. in others, it is gradual. the cause is not known. there is no single test to diagnose polymyalgia rheumatica. your doctor will use your medical history, symptoms, and a physical exam to make the diagnosis. lab tests for inflammation may help confirm the diagnosis. polymyalgia rheumatica sometimes occurs along with giant cell arteritis, a condition that causes swelling of the arteries in your head. symptoms include headaches and blurred vision. doctors often prescribe prednisone, a steroid medicine, for both conditions. with treatment, polymyalgia rheumatica usually disappears in a day or two. without treatment, it usually goes away after a year or more. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Polymyalgia Rheumatica, also known as rhizomelic pseudopolyarthritis, is related to arthritis and rheumatoid arthritis. An important gene associated with Polymyalgia Rheumatica is IL1RN (interleukin 1 receptor antagonist), and among its related pathways are Malaria and PEDF Induced Signaling. The compounds estrogen and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone, and related mouse phenotype immune system.

Wikipedia:63 Polymyalgia rheumatica (which takes its name from the word \"polymyalgia\" which means \"pain in many... more...

Aliases & Classifications for Polymyalgia Rheumatica

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Sources:
8Disease Ontology, 44Novoseek, 48Orphanet, 33MedlinePlus, 56SNOMED-CT, 27ICD9CM, 39NCIt, 60UMLS, 34MeSH, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

polymyalgia rheumatica 8 44 48 33
rhizomelic pseudopolyarthritis 48


External Ids:

Disease Ontology8 DOID:853
ICD9CM27 725
NCIt39 C85018
MeSH34 D011111
UMLS via Orphanet61 C1527406
ICD10 via Orphanet26 M31.6
ICD1025 M35.3

Related Diseases for Polymyalgia Rheumatica

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17GeneCards, 18GeneDecks
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Diseases related to Polymyalgia Rheumatica via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.3CRP, HLA-DRB1, CCL5, HP, CXCL1, IL1RN
2rheumatoid arthritis31.3CCL5, TLR9, SERPINA3, MMP3, IL2RB, IL1RAPL2
3vasculitis31.0IL1RAPL2, CXCL1, CRP, APOH
4synovitis30.9MMP3, IL1R1, IL1RN, CRP
5influenza30.8CCL5, TLR9, IL2RB, MX1
6aortic aneurysm30.6CRP
7amyloidosis30.5CRP, IL1RAPL2, SERPINA3
8pneumonia30.5CCL5, CRP, CXCL1, IL1RAPL2, IL2RB
9meningitis30.4CRP, CXCL1
10hepatitis30.4HP, IL1RAPL2, IL2RB, MX1
11diabetes mellitus30.4MMP3, IL1R1, HP, CRP, HLA-DRB1
12tuberculosis30.4TLR9, HLA-DRB1, CRP, HP, IL12B, IL1RAPL2
13prostate cancer30.4CCL5, TLR9, CXCL1, IL1R1, MX1, SERPINA3
14leukemia30.4HLA-DRB1, HP, CXCL1, IL12B, IL1R1, IL1RAPL2
15bronchiolitis30.2CCL5
16uveitis30.2IL1R1
17adenocarcinoma30.2SERPINA3, IL1RAPL2, CCL5
18myositis30.2SERPINA3, IL1RAPL2, IL1RN
19neutropenia30.2IL1RN
20dementia30.2IL1RAPL2, MMP3, SERPINA3
21myocardial infarction30.2SERPINA3, IL1RAPL2, CRP, CCL5
22glomerulonephritis30.2IL1R1, IL1RN, TLR9
23ischemia30.2HP, IL2RB, MMP3
24arthropathy30.2CRP, IL1RN, IL1RAPL2, MMP3
25colon cancer30.2TLR9, CXCL1, MMP3
26vascular disease30.2APOH, HP, IL1RN, MMP3
27primary biliary cirrhosis30.2TLR9, HLA-DRB1, IL2RB
28sarcoidosis30.2SERPINA3, IL2RB, IL1RAPL2, IL1RN, IL12B, HLA-DRB1
29ankylosing spondylitis30.2CRP, HP, IL1RN, IL1R1, IL1RAPL2, MMP3
30antiphospholipid syndrome30.2APOH
31breast cancer30.2CCL5, TLR9, CXCL1, IL1R1, IL1RAPL2, MMP3
32ulcerative colitis30.2TLR9, HLA-DRB1, CRP, CXCL1, IL12B, IL1RN
33atherosclerosis30.2HP, CRP, APOH, TLR9, CCL5, CXCL1
34temporal arteritis11.1
35bursitis10.6
36rhizomelic pseudopolyarthritis10.5
37cellulitis10.4
38cervicitis10.4
39prostatitis10.4
40spondylitis10.4
41spondyloarthropathy10.4
42acute myeloid leukemia10.3
43aortitis10.3
44miliary tuberculosis10.3
45dissecting aortic aneurysm10.3
46acute leukemia10.3
47osteoporosis10.3
48endocarditis10.3
49giant cell tumor10.3
50myeloid leukemia10.3

Graphical network of the top 20 diseases related to Polymyalgia Rheumatica:



Diseases related to polymyalgia rheumatica

Clinical Features for Polymyalgia Rheumatica

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Drugs & Therapeutics for Polymyalgia Rheumatica

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Polymyalgia Rheumatica

Drug clinical trials:

Search ClinicalTrials for Polymyalgia Rheumatica

Search NIH Clinical Center for Polymyalgia Rheumatica

Search CenterWatch for Polymyalgia Rheumatica

Genetic Tests for Polymyalgia Rheumatica

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Anatomical Context for Polymyalgia Rheumatica

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32MalaCards
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MalaCards organs/tissues related to Polymyalgia Rheumatica:

32
Testes, Skin, Bone, Pituitary, T cells, Colon, Prostate, Myeloid, B cells, Endothelial, Skeletal muscle, Breast, Kidney, Adrenal gland, Monocytes

Animal Models for Polymyalgia Rheumatica or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polymyalgia Rheumatica:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.4MMP3, TLR9, CRP, HP, IL12B, IL12A

Publications for Polymyalgia Rheumatica

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50PubMed
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Articles related to Polymyalgia Rheumatica:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Epitope mapping of antibodies against ferritin heavy chain in giant cell arteritis and polymyalgia rheumatica. (23682607)
2013
2
Modified reduction aortoplasty with external reinforcement of the ascending aortic aneurysm caused by giant cell arteritis treated as polymyalgia rheumatica. (22893318)
2013
3
Ultrasound in assessment of cervical interspinous bursitis in polymyalgia rheumatica. (23622973)
2013
4
Subclinical vasculitis in polymyalgia rheumatica. (24105317)
2013
5
Giant cell arteritis and polymyalgia rheumatica after influenza vaccination: report of 10 cases and review of the literature. (22235046)
2012
6
ESR can be normal in giant cell arteritis and polymyalgia rheumatica. (22374896)
2012
7
A difficult case of polymyalgia rheumatica. (22859535)
2012
8
Polymyalgia rheumatica as presenting manifestation of vasculitis involving the lower extremities in a patient with ulcerative colitis. (22640654)
2012
9
Where does polymyalgia rheumatica end and giant cell arteritis begin? Lessons from positron emission tomography studies. (23340142)
2012
10
Toll-like receptor 9 gene polymorphisms in polymyalgia rheumatica and giant cell arteritis. (23043436)
2012
11
Glucocorticoid treatment of polymyalgia rheumatica. (22018201)
2011
12
Circulating cytokines in active polymyalgia rheumatica. (19254903)
2010
13
Cancer risk in patients hospitalized with polymyalgia rheumatica and giant cell arteritis: a follow-up study in Sweden. (20299378)
2010
14
Increased muscle interstitial levels of inflammatory cytokines in polymyalgia rheumatica. (20812339)
2010
15
Changes in adiponectin and leptin concentrations during glucocorticoid treatment: a pilot study in patients with polymyalgia rheumatica. (20398023)
2010
16
A significant association between impaired glucose metabolism and polymyalgia rheumatica. (20693748)
2010
17
Methotrexate treatment of polymyalgia rheumatica/giant cell arteritis-associated large vessel vasculitis. (20483056)
2010
18
Predictors for treatment success and expression of glucocorticoid receptor in giant cell arteritis and polymyalgia rheumatica. (19684157)
2009
19
The clinical implication of cervical interspinous bursitis in the diagnosis of polymyalgia rheumatica. (18474656)
2008
20
Polymyalgia rheumatica. (18390527)
2008
21
Polymyalgia rheumatica and elderly onset rheumatoid arthritis. (18431108)
2008
22
Comment on "Polymyalgia rheumatica as the manifestation of unclassified aortitis". (18437284)
2008
23
Evidence for a different anatomic basis for joint disease localization in polymyalgia rheumatica in comparison with rheumatoid arthritis. (17907197)
2007
24
Unilateral polymyalgia rheumatica with controlateral sympathetic dystrophy syndrome. A case of asymmetrical involvement due to pre-existing peripheral palsy. (17085469)
2006
25
Synovial expression of vasoactive intestinal peptide in polymyalgia rheumatica. (17181926)
2006
26
The role of anticyclic citrullinated peptide antibodies in the differential diagnosis of elderly-onset rheumatoid arthritis and polymyalgia rheumatica. (16514472)
2006
27
Acute onset of polymyalgia rheumatica in pregnancy. (16260569)
2005
28
Cerivastatin-induced polymyalgia rheumatica-like illness. (15045638)
2004
29
Polymyalgia rheumatica preceding small-vessel vasculitis: changed spots or misdiagnosis? (15100422)
2004
30
Giant-cell arteritis and polymyalgia rheumatica. (13679329)
2003
31
Ultrasonography of temporal arteries discloses temporal arteritis in "pure" polymyalgia rheumatica patients. (12532975)
2002
32
Polymyalgia rheumatica and giant-cell arteritis. (12494942)
2002
33
In polymyalgia rheumatica serum prolactin is positively correlated with the number of typical symptoms but not with typical inflammatory markers. (11961173)
2002
34
Local injections in polymyalgia rheumatica. (11950036)
2002
35
No increased frequency of malignant neoplasms in polymyalgia rheumatica and temporal arteritis. A prospective longitudinal study of 398 cases and matched population controls. (12375324)
2002
36
Survival in polymyalgia rheumatica and temporal arteritis: a study of 398 cases and matched population controls. (11709607)
2001
37
Musculoskeletal manifestations in polymyalgia rheumatica and temporal arteritis. (11602480)
2001
38
Prednisolone maintenance dose in relation to starting dose in the treatment of polymyalgia rheumatica and temporal arteritis. A prospective two-year study in 273 patients. (11727839)
2001
39
Polymyalgia rheumatica: evidence for a hypothalamic-pituitary-adrenal axis-driven disease. (11138324)
2000
40
Ultrasonography of the glenohumeral joints--a helpful instrument in differentiation in elderly onset rheumatoid arthritis and polymyalgia rheumatica. (10984136)
2000
41
Polymyalgia rheumatica with normal erythrocyte sedimentation rate: clinical aspects. (10948758)
2000
42
Corticosteroids in polymyalgia rheumatica--a review of different treatment schedules. (10948765)
2000
43
Evaluating an alternative oral regimen for the treatment of polymyalgia rheumatica. (19078451)
2000
44
Steroid sparing therapeutic approaches to polymyalgia rheumatica-giant cell arteritis. State of the art and perspectives. (10948766)
2000
45
Polymyalgia rheumatica: a disorder of extraarticular synovial structures? (10090155)
1999
46
HLA-DRB1 alleles associated with polymyalgia rheumatica in northern Italy: correlation with disease severity. (10225816)
1999
47
Cytokines and adhesion molecules in patients with polymyalgia rheumatica. (9714354)
1998
48
Polymyalgia rheumatica in biopsy proven giant cell arteritis does not constitute a different subset but differs from isolated polymyalgia rheumatica. (9733456)
1998
49
Diagnosing and managing polymyalgia rheumatica and temporal arteritis. Repeated measurements of erythrocyte sedimentation rate are not efficient use of time or resources. (9329329)
1997
50
Anti-neutrophil cytoplasmic antibodies in giant cell arteritis and polymyalgia rheumatica. (8296636)
1993

Genetic Variations for Polymyalgia Rheumatica

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Expression for genes affiliated with Polymyalgia Rheumatica

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polymyalgia Rheumatica

Search GEO for disease gene expression data for Polymyalgia Rheumatica.

Pathways for genes affiliated with Polymyalgia Rheumatica

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Sources:
29KEGG, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome
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Pathways related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2TLR9, KLRB1
2
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10.2IL12A, CXCL1
3
Development Thrombopoetin signaling via JAK-STAT pathway
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10.2CRP, IL1RN, SERPINA3
410.1TLR9, IL12B, IL12A
5
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10.1TLR9, IL12B, IL12A
6
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10.1IL1R1, IL12B, TLR9
710.1IL12B, CXCL1, HLA-DRB1
810.1CXCL1, IL12B, IL12A
910.1IL2RB, IL12A, IL12B, HLA-DRB1
10
Hide members
10.0TLR9, HLA-DRB1, IL1R1, IL2RB
1110.0TLR9, HLA-DRB1, IL12B, IL12A
12
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10.0CCL5, TLR9, IL12B, IL12A
13
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10.0IL1R1, IL12A, IL12B, TLR9
14
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10.0IL2RB, IL12A, IL12B, CXCL1
1510.0CXCL1, IL12B, IL12A, IL1R1
16
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10.0HLA-DRB1, IL1RN, IL1R1, IL2RB, MX1
17
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9.9HLA-DRB1, IL12B, IL12A, IL1R1, IL2RB
18
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9.9CCL5, IL12B, IL12A, IL1R1, IL2RB
19
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9.8TLR9, HLA-DRB1, IL1RN, IL1R1, IL2RB, MX1
20
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9.8CCL5, CXCL1, IL12B, IL12A, IL1R1, IL2RB
21
Hide members
9.7MX1, IL2RB, IL12A, IL12B, HLA-DRB1, TLR9
22
Hide members
9.7CCL5, TLR9, CXCL1, IL12B, IL12A, IL1R1

Compounds for genes affiliated with Polymyalgia Rheumatica

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6APOH
2endotoxin4410.6CXCL1, APOH
3cycloheximide4410.6IL2RB, MX1, IL1RAPL2
4anakinra44 1111.3IL1RAPL2, IL1R1, IL1RN, CRP
5amphotericin b4410.3IL1RN, IL1R1, IL1RAPL2, CCL5, CRP
6pentoxifylline44 1111.3IL1RN, IL1RAPL2, IL1R1, IL12B, IL2RB
7polysulfone4410.3IL2RB, IL1R1, IL1RN, CRP, IL1RAPL2
8adalimumab44 49 1112.3IL1RAPL2, IL1RN, CRP, IL1R1, MMP3
9rantes4410.3IL2RB, CXCL1, IL1R1, IL12B, IL1RAPL2
10hydroxychloroquine44 1111.3TLR9, APOH, CRP, IL1R1
11leflunomide49 44 1112.2IL1RN, IL1RAPL2, IL2RB, MMP3, IL1R1
12il 104410.2IL1RAPL2, IL1RN, IL12B, CCL5, IL2RB, IL1R1
13lipoteichoic acid4410.2IL1R1, TLR9, IL1RN, IL12B, APOH
14dexamethasone44 49 28 1113.2CXCL1, CCL5, SULT2A1, IL1RAPL2, IL1R1
15ivig4410.2IL2RB, IL1RAPL2, CRP, IL1R1, APOH, IL1RN
16prednisolone44 28 1112.2MMP3, APOH, CRP, IL1R1, IL1RAPL2, IL2RB
17neopterin4410.1CRP, HP, IL2RB, IL1RAPL2, IL1R1, IL1RN
18peptidoglycan44 2811.1IL1R1, IL1RN, TLR9, CCL5, IL12B
19etanercept44 49 1112.1IL1R1, IL1RN, MMP3, IL2RB, IL1RAPL2, APOH
20cuprophan4410.1IL1RAPL2, IL2RB, IL1RN, IL1R1
21leukotriene b444 59 2412.1CXCL1, IL2RB, IL1RAPL2, IL1R1, IL1RN, CCL5
22cyclosporin a44 28 5912.1IL1R1, HP, CCL5, IL2RB, IL1RAPL2, CXCL1
23aspirin44 49 28 2413.0IL2RB, APOH, IL1RAPL2, IL1R1, CRP, CCL5
24nacl4410.0SERPINA3, IL1R1, IL1RAPL2, MMP3, SULT2A1, CCL5
25sulfasalazine44 28 49 1113.0IL12B, MMP3, IL1RAPL2, IL1R1, IL1RN, CRP
26infliximab44 49 1112.0IL1R1, IL1RN, IL2RB, CXCL1, CRP, APOH
27methionine449.9SERPINA3, IL1RAPL2, MMP3, HP, IL2RB, IL1R1
28ribonucleic acid449.9MMP3, IL2RB, IL1RAPL2, IL1R1, IL1RN, CCL5
29polyethylene glycol449.9IL1RN, IL1RAPL2, HP, CRP, IL1R1
30acth449.9IL2RB, HP, IL1RN, IL1R1, IL1RAPL2, SULT2A1
31sb 20358044 5910.9MMP3, IL1R1, IL1RN, CCL5, CRP, IL12B
32vitamin d449.9CCL5, IL1R1, MMP3, SULT2A1, IL12B, HP
33iron44 2410.9IL1R1, IL1RAPL2, IL2RB, MMP3, SERPINA3, APOH
34fibrinogen449.9IL1RN, APOH, CRP, SERPINA3, HP, IL1RAPL2
35lactate449.9CCL5, MMP3, IL1R1, IL1RN, HP, CRP
36polyacrylamide449.8APOH, HP, IL12B, IL1RN, SULT2A1, SERPINA3
37creatinine449.8CCL5, APOH, IL1RN, CRP, IL2RB, IL1R1
38alanine449.8CCL5, HLA-DRB1, HP, IL1RN, IL1R1, IL2RB
39heparin44 28 11 2412.8SERPINA3, MMP3, APOH, HP, IL1RAPL2, IL1R1
40progesterone44 59 28 11 2413.8MMP3, APOH, IL1RN, SERPINA3, HP, CXCL1
41cholesterol44 28 11 2412.7SULT2A1, IL1RAPL2, IL1R1, MMP3, IL2RB, IL1RN
42vegf449.7IL1RN, HP, CRP, APOH, CCL5, IL1R1
43nitric oxide44 11 2411.6IL1R1, IL1RN, CCL5, IL12B, CXCL1, APOH
44lipid449.6CRP, IL1R1, SULT2A1, SERPINA3, MMP3, CCL5
45methotrexate44 49 1111.5IL1RAPL2, IL1R1, IL1RN, CRP, HLA-DRB1, APOH
46serine449.5HP, IL2RB, IL1RN, IL1R1, CXCL1, IL1RAPL2
47retinoic acid44 2410.3KRT15, MMP3, IL1R1, IL2RB, IL1RAPL2, IL1RN
48tyrosine449.2NM, MMP3, IL2RB, IL1R1, IL1RN, CXCL1
49calcium44 49 11 2412.2MMP3, IL1RAPL2, IL1R1, IL1RN, IL12B, CXCL1
50atp44 2810.1KRT15, MX1, MMP3, IL1RAPL2, IL1RN, HP

GO Terms for genes affiliated with Polymyalgia Rheumatica

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Sources:
16Gene Ontology
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Cellular components related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 complexGO:04351410.0IL12B, IL12A
2extracellular regionGO:0055769.5SERPINA3, MMP3, IL1R1, CXCL1, HP, CRP
3extracellular spaceGO:0056159.2SERPINA3, CCL5, APOH, CRP, HP, CXCL1

Biological processes related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.5IL12B, IL12A
2positive regulation of NK T cell activationGO:05113510.5IL12B, IL12A
3positive regulation of lymphocyte proliferationGO:05067110.5IL12B, IL12A
4maintenance of gastrointestinal epitheliumGO:03027710.5TLR9, SERPINA3
5positive regulation of cell adhesionGO:04578510.4CCL5, IL12B, IL12A
6positive regulation of activation of JAK2 kinase activityGO:01053510.4CCL5, IL12B
7positive regulation of T cell proliferationGO:04210210.4IL12A, IL12B, CCL5
8acute-phase responseGO:00695310.4SERPINA3, IL1RN, HP, CRP
9positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.4IL12B, IL12A
10positive regulation of smooth muscle cell apoptotic processGO:03439310.4IL12B, IL12A
11positive regulation of natural killer cell activationGO:03281610.3IL12B, IL12A
12T-helper 1 type immune responseGO:04208810.3IL12B, HLA-DRB1
13negative regulation of interleukin-17 productionGO:03270010.3IL12A, IL12B
14inflammatory responseGO:00695410.2CCL5, TLR9, CRP, CXCL1, SERPINA3
15immune responseGO:00695510.2IL1R1, IL1RN, IL12A, CXCL1, HLA-DRB1
16response to UV-BGO:01022410.2IL12B, IL12A
17positive regulation of interferon-gamma biosynthetic processGO:0450789.9IL12B, TLR9

Molecular functions related to Polymyalgia Rheumatica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.3IL1RN, TLR9
2interleukin-12 receptor bindingGO:00514310.2IL12A, IL12B
3interleukin-1 receptor activityGO:0049089.9IL1RAPL2, IL1R1

Products for genes affiliated with Polymyalgia Rheumatica

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  • Antibodies
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Sources for Polymyalgia Rheumatica

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet