Polymyositis malady

NIH Rare Diseases: Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.  Polymyositis affects skeletal muscles (those involved with making movement) on both sides of the body.  It is rarely seen in persons under age 18; most cases are seen in adults between the ages of 31 and 60. The cause of polymyositis is not fully understood. Although there's no cure for polymyositis, treatment can improve muscle strength and function.³⁰

MalaCards: Polymyositis is related to inclusion body myositis and muscular dystrophy. An important gene associated with Polymyositis is EXOSC9 (exosome component 9), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Aminoacyl-tRNA biosynthesis. The compounds cyclophosphamide and glucose have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, lung and thyroid, and related mouse phenotypes are respiratory system and renal/urinary system.

NINDS: Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.³¹

Wikipedia: Polymyositis (PM)(\"inflammation of many muscles\") is a type of chronic inflammation of the muscles...⁴⁴ more...

polymyositis 30 31 32 43

Diseases related to polymyositis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 846)

id	Related Disease	Score	Top Affiliating Genes
1	inclusion body myositis	31.2	VCAM1, CD80, ICAM1, HLA-B, RPS27A, COX5A
2	muscular dystrophy	29.6	PIK3C2A, NCAM1, UTRN, CHKB, LAMA2, DYSF
3	adult dermatomyositis	29.1	PIK3C2A, VCAM1, CHKB, ICAM1, TNF
4	interstitial lung disease	29.1	SFTPD, IL1A, IL1RAPL2, IL1RN, CCL2, CCL3
5	hypothyroidism	29.1	CD80, IL1A, IFNA1, IFNB1, CALCA
6	bronchiolitis obliterans organizing pneumonia	29.0	PIK3C2A, CHKA, MAPKAP1, IFNA2, CRP
7	primary biliary cirrhosis	28.8	GZMB, HSPG2, HLA-B, HLA-DRB1, CTLA4, RNPC3
8	connective tissue disease	28.5	SFTPD, S100A9, FBL, HSPG2, RNPC3
9	limb-girdle muscular dystrophy	28.4	CHKB, LAMA2, DYSF, DMD, TTN, GAA
10	mixed connective tissue disease	28.0	PIK3C2A, S100A8, S100A9, MICA, HSPG2, HLA-A
11	duchenne muscular dystrophy	27.9	PIK3C2A, UTRN, CHKA, CHKB, CD59, MB
12	t-cell leukemia	27.5	CNTN2, JUN, CD28, CD40, ITGA4, IL1A
13	hepatitis	27.3	IFNA1, SOD2, SLC17A5
14	polyarteritis nodosa	27.2	CHKB, IFNA1, IFNA2, CRP
15	was-related disorders	27.2	CHKB, IL2RA, CALCA, HLA-B, DMD, CRP
16	myositis	26.8	PIK3C2A, NCAM1, SERPINA3, VCAM1, MYBPC1, UTRN
17	tropical spastic paraparesis	26.6	CNTN2, ITGB2, IL15, IL2RA, FASLG, CCL3
18	bronchiolitis obliterans	25.6	PIK3C2A, SFTPD, CHKA, CHKB, GZMB, IL17A
19	autoimmune thyroiditis	25.4	CHKB, CD59, CD80, CD40, ITGB2, IL2RA
20	spastic paraparesis	25.1	CNTN2, VEGFA, JUN, CD8A, CD274, IL15
21	spasticity	24.1	CNTN2, VEGFA, JUN, CD8A, CD274, ITGB2
22	graft versus host disease	23.6	CD28, GZMB, IL15, IL1RAPL2, IL2RA, IL4
23	pulmonary hypertension	22.9	PIK3C2A, VWF, VEGFA, IL1A, CCL2, CCL3
24	polymyalgia rheumatica	22.7	VWF, SERPINA3, VEGFA, IL1A, IL1RAPL2, IL1RN
25	bronchiolitis	22.6	PIK3C2A, SFTPD, SELE, VCAM1, CHKA, CHKB
26	hepatitis c	22.5	JUN, CD28, IL4, FAS, CCR5, IFNA1
27	renal cell carcinoma	22.5	VEGFA, CLU, CHKA, JUN, CD86, CD59
28	dermatomyositis	22.4	PIK3C2A, VWF, SFTPD, SELE, SERPINA3, VEGFA
29	myopathy	22.3	PIK3C2A, NCAM1, SELE, VCAM1, MYBPC1, UTRN
30	hyperthyroidism	21.6	PIK3C2A, VWF, SELE, CHKB, CD40, IL2RA
31	immunodeficiency	21.5	CD28, CD80, CD274, CD40, ITGA4, ITGB2
32	pulmonary fibrosis	20.6	VWF, SFTPD, SELE, VEGFA, S100A9, JUN
33	systemic lupus erythematosus	20.4	VWF, SELE, VCAM1, CLU, S100A8, S100A9
34	esophageal cancer	20.0	SERPINA3, VEGFA, CHKA, XRCC5, S100A9, MSH2
35	pneumonia	19.5	PIK3C2A, SFTPD, SELE, VEGFA, VCAM1, CHKA
36	hypertension	17.6	PIK3C2A, NCAM1, VWF, SELE, SERPINA3, VEGFA
37	pancreatic cancer	17.4	NCAM1, VWF, SELE, SERPINA3, VEGFA, VCAM1
38	fibrosis	16.3	VWF, SFTPD, SELE, SERPINA3, VEGFA, VCAM1
39	esophagitis	16.0	PIK3C2A, NCAM1, SFTPD, SELE, SERPINA3, VEGFA
40	lupus erythematosus	15.7	PIK3C2A, VWF, SFTPD, SELE, SERPINA3, VEGFA
41	creatine phosphokinase, elevated serum	14.1	PIK3C2A, CHKB, MB, HMGCR
42	respiratory failure	14.0	PIK3C2A, SFTPD, GAA
43	extrinsic allergic alveolitis	14.0	SFTPD, CD80, IL1A, CCL3
44	compartment syndrome	14.0	CHKA, CHKB, MB
45	limb-girdle muscular dystrophy type 2i	14.0	CHKB, LAMA2, DYSF, TTN
46	neuroleptic malignant syndrome	14.0	PIK3C2A, CHKA, CHKB, MB
47	muscle disorders	14.0	CHKA, CHKB, TNNI3, TTN, GAA
48	gas gangrene	14.0	PIK3C2A, CHKB, HSPG2, TNNI3, DMD
49	middle ear cholesteatoma	14.0	CHKB, S100A8, IL1A, ICAM1
50	distal muscular dystrophy	14.0	PIK3C2A, DYSF, DMD, TTN, DES, GAA

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to polymyositis:

²²

MGI Mouse Phenotypes related to polymyositis:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.4	TNNI3, SFTPD, DMD, TNFRSF4, MB, CALCA
2	renal/urinary system phenotype	MP:0005367	10.0	DMD, SOD2, HELLS, CLU, CD180, TNFRSF1B
3	hematopoietic system phenotype	MP:0005397	9.2	SOD2, CD80, CD180, CD8A, CD86, CD28
4	endocrine/exocrine gland phenotype	MP:0005379	9.1	FASLG, LAMA2, IFNG, DMD, CTLA4, LTA
5	other phenotype	MP:0005395	9.1	SOD2, CLU, HSPG2, PTGS2, PTGS1, DMD
6	no phenotypic analysis	MP:0003012	8.9	KRT19, SST, DMD, PRNP, VEGFA, VCAM1
7	growth/size phenotype	MP:0005378	8.8	KRT19, GAA, FAS, IL2RA, JUN, XRCC5
8	skeleton phenotype	MP:0005390	8.5	SQSTM1, TTN, HELLS, GAA, IL17A, ITGB2
9	liver/biliary system phenotype	MP:0005370	8.5	IFNG, VEGFA, TLR2, CTLA4, SQSTM1, TLR4
10	nervous system phenotype	MP:0003631	8.2	CD8A, CD80, FASLG, GARS, CCL3, CD86
11	adipose tissue phenotype	MP:0005375	7.8	NEB, PIK3C2A, CCL2, ALOX5, TNF, TNFRSF1B
12	muscle phenotype	MP:0005369	7.7	CLU, CHKB, SOD2, PRNP, UTRN, VEGFA
13	digestive/alimentary phenotype	MP:0005381	7.5	TNFRSF4, HSPG2, PTGS1, DMD, SST, CTLA4
14	immune system phenotype	MP:0005387	7.2	VWF, CLU, LAMA2, XRCC5, HLA-DQA1, HLA-DQB1
15	integument phenotype	MP:0010771	6.9	AARS, MSH2, SQSTM1, IL4, FASLG, FAS
16	normal phenotype	MP:0002873	6.5	SST, CD28, JUN, TNFRSF4, DMD, ITGB2
17	tumorigenesis	MP:0002006	6.5	IFNB1, TNFRSF1B, TNF, IFNG, CCR5, CCL2
18	behavior/neurological phenotype	MP:0005386	6.4	CCL2, TNNI3, FAS, CD274, CD86, JUN
19	mortality/aging	MP:0010768	6.1	CD8A, MB, MAPKAP1, CCL2, CCR5, CCL3
20	reproductive system phenotype	MP:0005389	5.8	CCL2, UTRN, LAMA2, XRCC5, CD59, IL15
21	vision/eye phenotype	MP:0005391	5.7	IFNG, HSPG2, CCR7, CCR5, CCL2, VEGFA
22	cardiovascular system phenotype	MP:0005385	4.9	DMD, PTGS1, PTGS2, TNNI3, TNFRSF1B, CRP
23	homeostasis/metabolism phenotype	MP:0005376	4.8	CCR5, PTGS2, PTGS1, DMD, SST, CTLA4
24	cellular phenotype	MP:0005384	3.3	ITGB2, CCL3, CCR7, IFIH1, IFNB1, IFNG

Articles related to polymyositis:

(show top 50)    (show all 115)

id	Title	Authors	Year	Affiliating Genes
1	Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis. (19953283)	Kim G.T.... Kim S.I.	2010	TLR2, TLR4, TLR9
2	Beware of 'normal' creatine kinase levels in HIV-asso ciated polymyositis. (20459937)	Kenyon C.... Heckmann J.M.	2010	CHKA
3	Recent advance in polymyositis and dermatomyositis research (19280927)	Kohsaka H.	2009	MYBPC1
4	An autopsied case of thoracic esophageal cancer with polymyositis (19498309)	Hirata T.... Shinomura Y.	2009	CHKA
5	Monocyte chemotactic protein-1 single nucleotide polymorphisms do not confer susceptibility for the development of adult onset polymyositis/dermatomyositis in UK Caucasians. (17065190)	Chinoy H.... Cooper R.G.	2007	CCL2
6	Anti-synthetase syndrome: a new autoantibody to phenylalanyl transfer RNA synthetase (anti-Zo) associated with polymyositis and interstitial pneumonia. (17392287)	Betteridge Z.... McHugh N.	2007	FARSA
7	A case of polymyositis with concomitant diffuse alveolar damage following interstitial pneumonia (17233391)	Shingu A.... Kudo S.	2006	PIK3C2A
8	Expression of granulysin in polymyositis and inclusion-body myositis. (16980658)	Ikezoe K.... Kira J.I.	2006	GNLY
9	Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis. (16431335)	Sallum A.M.... Marie S.K.	2006	ICAM1, VCAM1
10	A study of vascular factor in the pathogenesis of polymyositis. (15840223)	Wang M.... Da Y.W.	2005	ICAM1, IL1A
11	Acute polymyositis during treatment of acute hepatitis C with pegylated interferon alpha-2b. (16169301)	Venezia G.... Almasio P.L.	2005	IFNA2
12	PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome. (14872500)	Raijmakers R.... Pruijn G.J.	2004	EXOSC9, EXOSC10
13	Immunolocalization of protectin (CD59) and macrophages in polymyositis and dermatomyositis. (15020079)	Gendek-Kubiak H.... Gendek E.G.	2004	CD59
14	Association of the proinflammatory haplotype (MICA5.1/TNF2/TNFa2/DRB1*03) with polymyositis and dermatomyositis. (15022353)	Hassan A.B.... Padyukov L.	2004	TNF, HLA-DRB1, MICA
15	S-protein is expressed in necrotic fibers in Duchenne muscular dystrophy and polymyositis. (12707977)	Louboutin J.P.... Blanchard D.	2003	CD59
16	Development of the myositis activities profile--validity and reliability of a self-administered questionnaire to assess activity limitations in patients with polymyositis/dermatomyositis. (12415597)	Alexanderson H.... StenstrAPm C.H.	2002	PIK3C2A
17	Critical requirement for professional APCs in eliciting T cell responses to novel fragments of histidyl-tRNA synthetase (Jo-1) in Jo-1 antibody-positive polymyositis. (12471150)	Ascherman D.P.... Wright T.M.	2002	HARS
18	Women with pregnancy-related polymyositis and high se rum CK levels in the newborn. (11839858)	Messina S.... Sciacco M.	2002	CHKB
19	Association of HLA-DQB1 alleles and dermatomyositis/ polymyositis (12170471)	Han X.... Song F.	2002	HLA-DQB1
20	Polymyositis evolving after rhabdomyolysis associated with HMG-CoA reductase inhibitors: a report of two cases. (17039165)	Gupta S.... Crofford L.J.	2001	HMGCR
21	Difference in B cell activation between dermatomyositis and polymyositis: analysis of the expression of RP105 on peripheral blood B cells. (11709456)	Kikuchi Y.... Nagasawa K.	2001	CD180
22	Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. (10638867)	Wiesinger G.F.... Graninger W.	2000	PIK3C2A
23	The role of lymphotoxin in pathogenesis of polymyositis. (11045674)	Liang Y.... Sobue G.	2000	TNF, FAS, FASLG
24	Decreased expression of interleukin-1alpha, interleukin-1beta, and cell adhesion molecules in muscle tissue following corticosteroid treatment in patients with polymyositis and dermatomyositis. (10693873)	Lundberg I.... Patarroyo M.	2000	ICAM1, IL1A
25	Increased CD40 expression on muscle cells of polymyositis and dermatomyositis: role of CD40-CD40 ligand interaction in IL-6, IL-8, IL-15, and monocyte chemoattractant protein-1 production. (10843719)	Sugiura T.... Kamatani N.	2000	CD40, IL15
26	Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis. (11055823)	Shimizu T.... Horie T.	2000	TNFRSF1B
27	Abnormal IL-1 receptor antagonist production in patie nts with polymyositis and dermatomyositis. (10732829)	Son K.... Horie T.	2000	IL1RN
28	Corticosteroid resistant interstitial pneumonitis in dermatomyositis/polymyositis: prediction and treatment with cyclosporine. (10405940)	Nawata Y.... Iwamoto I.	1999	PIK3C2A
29	Elevation of cytokeratin 19 fragment in patients with interstitial pneumonia associated with polymyositis/dermatomyositis. (10555895)	Fujita J.... Takahara J.	1999	KRT19
30	Improvement of physical fitness and muscle strength in polymyositis/dermatomyositis patients by a training programme. (9569076)	Wiesinger G.F.... Graninger W.	1998	PIK3C2A
31	A case of polymyositis with anti-Jo-1 antibody preceded by BOOP (9666682)	Takahashi H.... Nakamura N.	1998	PIK3C2A
32	Elevated serum levels of neopterin in adult patients with polymyositis/dermatomyositis. (9236675)	Samsonov M.Y.... Fuchs D.	1997	IL2RA
33	Polymyositis with cytochrome oxidase negative muscle fibres. Early quadriceps weakness and poor response to immunosuppressive therapy. (9055796)	Blume G.... Johns D.R.	1997	COX5A
34	Dystrophin abnormality in a patient with polymyositis associated with primary biliary cirrhosis and myocardial injury (8952356)	Tsai W.C.... Shimizu T.	1996	DMD
35	Wide cross-species aminoacyl-tRNA synthetase replacement in vivo: yeast cytoplasmic alanine enzyme replaced by human polymyositis serum antigen. (7761427)	Ripmaster T.L.... Schimmel P.	1995	AARS
36	Clinical investigation for polymyositis and related disorders (7474450)	Matsubara S.	1995	CHKB
37	A search for human T-cell leukemia virus type I in the lesions of patients with tropical spastic paraparesis and polymyositis. (7668833)	Tangy F.... Ozden S.	1995	CNTN2
38	Onset of polymyositis with autoantibodies to threonyl-tRNA synthetase during pregnancy. (7983666)	Satoh M.... Reeves W.H.	1994	TARS
39	Muscle involvement in polyarteritis nodosa: report of a patient presenting clinically as polymyositis and review of the literature. (7914924)	Fort J.G.... Abruzzo J.L.	1994	CHKB
40	Polymyositis-like syndrome in hypothyroidism: report of two cases. (7536446)	Ciompi M.L.... Puccetti L.	1994	PIK3C2A
41	Elevated serum levels of interleukin-1 receptor antagonist in polymyositis/dermatomyositis. A biologic marker of disease activity with a possible role in the lack of acute-phase protein response. (7986220)	Gabay C.... Dayer J.M.	1994	TNF, CRP, IL1RN
42	Juvenile dermato/polymyositis: a retrospective analys is of 33 cases with special focus on initial CPK levels. (8070171)	van Rossum M.A.... Kuis W.	1994	PIK3C2A
43	Adult idiopathic polymyositis without elevation of creatine kinase. Case report and review of the literature. (8480146)	Gran J.T.... Johansen S.	1993	CHKB
44	Degradative activity of granzyme A on skeletal muscle proteins in vitro: a possible molecular mechanism for muscle fiber damage in polymyositis. (8268727)	Nakamura K.... Sugita H.	1993	GZMA, NEB
45	Immunocytochemical localization of ubiquitin in inclu sion body myositis allows its light-microscopic distinction from polymyositis. (1310532)	Askanas V.... Alvarez R.B.	1992	RPS27A
46	A case of bronchiolitis obliterans organizing pneumonia with positive anti Jo-1 antibody preceding polymyositis (1630059)	Imokawa S.... Chida K.	1992	PIK3C2A
47	Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex. (2007859)	Alderuccio F.... Tan E.M.	1991	EXOSC9
48	Correlation between tests of muscle involvement and clinical muscle weakness in polymyositis and dermatomyositis. (2088650)	Tymms K.E.... Buchanan W.W.	1990	CHKB
49	Interleukin-1 alpha, interleukin-2, and soluble interleukin-2 receptors in polymyositis. (2369417)	Wolf R.E.... Baethge B.A.	1990	IL2RA, IL1A, CHKB
50	Eosinophilic polymyositis induced by tranilast. (1693928)	Arase S.... Takeda K.	1990	MB

Genes related to polymyositis according to GeneCards:

(show top 50)    (show all 124)

id	Symbol	Description	Score	GeneCards Section Context
1	EXOSC9	exosome component 9	11.1	Summaries, Orthologs, Aliases & Descriptions, Publications
2	EXOSC10	exosome component 10	11.1	Publications, Orthologs, Aliases & Descriptions
3	HARS	histidyl-tRNA synthetase	11.1	Summaries, Functions, Publications
4	IARS	isoleucyl-tRNA synthetase	11.0	Summaries, Functions
5	GARS	glycyl-tRNA synthetase	11.0	Functions, Summaries
6	KARS	lysyl-tRNA synthetase	11.0	Functions, Summaries
7	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
8	TARS	threonyl-tRNA synthetase	11.0	Publications
9	CHKB	choline kinase beta	11.0	Publications
10	GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	11.0	Publications
11	CD59	CD59 molecule, complement regulatory protein	11.0	Publications
12	FBL	fibrillarin	11.0
13	CHKA	choline kinase alpha	11.0	Publications
14	SFTPD	surfactant protein D	11.0	Publications
15	RNPC3	RNA-binding region (RNP1, RRM) containing 3	11.0
16	CNTN2	contactin 2 (axonal)	11.0	Publications
17	CCR7	chemokine (C-C motif) receptor 7	11.0	Publications
18	S100A9	S100 calcium binding protein A9	11.0
19	GAA	glucosidase, alpha; acid	11.0
20	MB	myoglobin	11.0	Publications
21	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0	Publications
22	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0
23	IL15	interleukin 15	11.0	Publications
24	IL17A	interleukin 17A	11.0	Publications
25	CD80	CD80 molecule	11.0
26	CD86	CD86 molecule	11.0
27	CD28	CD28 molecule	11.0	Publications
28	ICAM1	intercellular adhesion molecule 1	11.0	Publications
29	IL1A	interleukin 1, alpha	11.0	Publications
30	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
31	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
32	RPS27A	ribosomal protein S27a	11.0	Publications
33	S100A8	S100 calcium binding protein A8	11.0
34	CCL3	chemokine (C-C motif) ligand 3	11.0
35	SELE	selectin E	11.0	Publications
36	TTN	titin	11.0
37	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
38	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0	Publications
39	PRNP	prion protein	11.0
40	DYSF	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	11.0
41	UTRN	utrophin	11.0
42	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
43	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.0	Publications
44	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
45	NCAM1	neural cell adhesion molecule 1	11.0
46	HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	11.0
47	LAMA2	laminin, alpha 2	11.0
48	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0
49	DMD	dystrophin	11.0	Publications
50	JUN	jun proto-oncogene	11.0

Pathways related to polymyositis according to GeneDecks:

(show top 50)    (show all 111)

id	Pathway	Score	Top Affiliating Genes
1	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.6	GZMB, GZMA, IL15, CCL3, FASLG, IL2RA
2	Aminoacyl-tRNA biosynthesis20	10.6	KARS, IARS, FARSA, TARS, AARS, HARS
3	Cell adhesion molecules (CAMs)20	10.5	CTLA4, ITGB2, ITGA4, CD40, CD80, CD8A
4	Graft-versus-host disease20	10.3	CD28, CD86, CD80, IL1A, HLA-DQA1, HLA-B
5	Lymphocyte Signaling3	10.2	GZMA, CD8A, IFIH1, XRCC5, NCAM1, IL2RA
6	Molecular Mechanisms of Cancer36	10.2	LTA, IL15, TNFRSF4, TNFRSF1B, CCR7, CCL21
7	Antigen processing and presentation20	10.1	CD8A, HLA-DQA1, HLA-DQB1, HLA-DRB1, HSP90AA1
8	Bacterial infections in CF airways41	10.1	SFTPD, TLR2
9	CD28 Signaling in T-Helper Cell36	10.0	CD28, CD86, HLA-DQA1, HLA-DQB1, HLA-DRB1, CTLA4
10	CTLA4 Signaling36	10.0	HLA-DQA1, CTLA4, HLA-DRB1, HLA-DQB1, CD80, CD28
11	Endothelin-1 Signaling Pathway36	10.0	CD80, CCL21, IL1A, CCL3, CCL19, IL4
12	Viral myocarditis20	9.9	DMD, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A
13	PGC1Alpha Pathway36	9.9	CD80, IL4, IL1A, IL15, CCL3, CCL19
14	Immune System38	9.6	CD40, IFIH1, IFNG, ICAM1, CTLA4, SQSTM1
15	Intestinal immune network for IgA production20	9.6	HLA-DQB1, HLA-DRB1, CD28, ITGA4, CD40, CD80
16	Glucocorticoid Receptor Signaling36	9.5	CCL2, JUN, CD80, CCL21, IL15, IL1A
17	STAT3 Pathway36	9.1	IL4, CCL3, CCL21, CCR7, CCR5, TNF
18	African trypanosomiasis20	9.1	FASLG, VCAM1, SELE, ICAM1, TLR9, TNF
19	Toll-like receptor signaling pathway20	9.0	IFNA2, TLR9, TNF, CD86, CD80, CD40
20	Antioxidant Action of Vitamin-C36	9.0	CCL2, IL4, IL2RA, IL1A, IL15, LTA
21	Akt Signaling36	9.0	IL15, HSP90AA1, LTA, CCR7, IL2RA, TNF
22	PEDF Induced Signaling36	8.9	CCL21, CCL2, IL15, IL1A, IL4, CCL3
23	p38 Signaling36	8.9	LTA, IL15, IL1A, IL2RA, IL4, CCL2
24	Systemic lupus erythematosus20	8.8	CD80, CD86, CD40, CD28, IFNG, HLA-DQA1
25	Immune response MIF-mediated glucocorticoid regulation10	8.7	ICAM1, VCAM1, PTGS2, IFNG, TNF, JUN
26	Autoimmune thyroid disease20	8.7	HLA-DQA1, CD40, CTLA4, HLA-DRB1, HLA-DQB1, HLA-B
27	all-trans-Retinoic Acid Signaling in Brain36	8.7	IL4, PTGS2, LTA, TNF, CD80, IL15
28	Th1 Differentiation37	8.7	JUN, TLR4, CD28, TLR9, CD86, TLR2
29	Tec Kinases Signaling36	8.7	IL4, IL2RA, IL15, ITGB2, ITGA4, CD80
30	NF-kappaB Signaling3	8.6	IFIH1, TLR4, TLR2, PTGS2, TNFRSF1B, FAS
31	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.6	IL17A, IL4, CCR7, IFNG, TLR2, TLR4
32	MIF Mediated Glucocorticoid Regulation36	8.5	CD80, IL15, CCL2, LTA, IL1A, IL4
33	MIF Regulation of Innate Immune Cells36	8.5	JUN, CD80, IL15, IL4, CCL2, LTA
34	Immune response_MIF-mediated glucocorticoid regulation41	8.4	JUN, TNF, ICAM1, IFNG, VCAM1, PTGS2
35	Rho Family GTPases36	8.4	LAMA2, LTA, DES, IL1A, IL4, CCL2
36	Malaria20	8.4	VCAM1, SELE, IFNG, TLR9, TLR4, TLR2
37	Type I diabetes mellitus20	8.4	HLA-DQA1, HLA-B, HLA-A, IFNG, FAS, FASLG
38	THC Differentiation Pathway36	8.3	HLA-DRB1, TNFRSF1B, TNF, HLA-DQB1, HLA-DQA1, IFNG
39	Cytokine Network36	8.3	LTA, IFNG, IFNB1, IFNA2, TNF, IFNA1
40	Natural killer cell mediated cytotoxicity20	8.1	IFNG, IFNB1, IFNA2, ICAM1, FASLG, MICA
41	Toxoplasmosis20	8.1	HLA-DQA1, ALOX5, HLA-DQB1, HLA-DRB1, TNF, TLR4
42	JAK-STAT Pathway36	8.1	CCL3, IL1A, IL2RA, TNFRSF1B, IL4, IFNG
43	Chagas disease (American trypanosomiasis)20	8.0	TLR4, TNF, JUN, FASLG, CCL3, FAS
44	Allograft rejection20	7.9	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A
45	Tuberculosis20	7.5	ITGB2, IL1A, IFNA1, TLR4, TLR9, TNF
46	Measles20	7.5	IFNG, TLR2, TLR4, TLR9, IL1A, CD28
47	Rheumatoid arthritis20	7.5	IL17A, IL15, ITGB2, CD80, CD86, CD28
48	Influenza A20	7.4	HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF, IFNA1, TLR4
49	Leishmaniasis20	7.1	HLA-DQA1, IFNG, IL4, IL1A, ITGB2, ITGA4
50	Cytokine-cytokine receptor interaction20	6.8	LTA, TNFRSF4, TNFRSF1B, IL17A, IL15, CD40

Compounds related to polymyositis according to GeneDecks:

(show top 50)    (show all 398)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.6	ITGA4, ITGB2
2	glucose32	10.3	UCN2, GZMB, IFNA2, AMPD1, DMD, KRT19
3	estrogen32	9.5	VWF, SERPINA3, CLU, CHKA, CHKB, GZMB
4	n acetylcysteine32	9.5	VWF, SELE, VCAM1, CLU, CD40, IL2RA
5	epinephrine32 9 18 9	12.5	PIK3C2A, SELE, CHKB, IL1A, IL1RAPL2, IL1RN
6	rapamycin32 42	10.3	VEGFA, CD86, CD80, GZMB, CCR5, IFNG
7	okt332	9.2	SELE, VCAM1, ITGB2, IL15, IL2RA, FAS
8	cysteine32	9.1	CNTN2, SFTPD, SERPINA3, CLU, CHKB, S100A8
9	heparin32 9 18 9	11.9	PIK3C2A, NCAM1, VWF, SERPINA3, CHKB, LAMA2
10	testosterone32 9 18 9	11.8	PIK3C2A, NCAM1, SELE, VCAM1, CLU, CHKA
11	glutamate32	8.7	NCAM1, CNTN2, CLU, CHKA, UCN2, S100A8
12	endotoxin32	8.7	SFTPD, CHKB, S100A8, S100A9, CD86, CD180
13	h2o232	8.5	CNTN2, VWF, CLU, S100A9, CD40, ITGB2
14	curcumin32	8.4	VEGFA, VCAM1, JUN, IL15, IL17A, IL1A
15	acetylcholine32 9 18 9	11.3	PIK3C2A, NCAM1, VWF, SERPINA3, UTRN, CHKA
16	vitamin d32	8.2	CLU, CHKA, CHKB, JUN, ITGB2, IL1A
17	arginine32	8.2	PIK3C2A, CNTN2, VWF, SERPINA3, UTRN, CHKB
18	sb 20358032 42	9.1	SELE, VEGFA, VCAM1, ITGB2, IL17A, IFNB1
19	fibrinogen32	8.1	PIK3C2A, SELE, SERPINA3, VCAM1, CLU, CHKB
20	atorvastatin32 34 9 18 9	12.0	PIK3C2A, VWF, SELE, VEGFA, VCAM1, CHKA
21	methotrexate32 34 42 9 9	11.9	PIK3C2A, SELE, SERPINA3, CHKB, S100A8, S100A9
22	norepinephrine32 9 18 9	10.9	PIK3C2A, VWF, SELE, VCAM1, CHKB, UCN2
23	triptolide32	7.8	VEGFA, JUN, CD86, CD40, CCL2, CCL3
24	calcium32 9 18 9	10.8	PIK3C2A, CNTN2, VWF, SFTPD, SERPINA3, MYBPC1
25	adenylate32	7.7	VWF, SELE, VCAM1, CHKA, CHKB, UCN2
26	ccl332	7.6	IL15, IL1A, CCL2, CCR5, CCL3, CCL21
27	pdtc32	7.6	SELE, VCAM1, JUN, CD40, IL1A, IL4
28	tarc32	7.6	ITGA4, IL1A, IL4, CCL2, CCR5, CCL3
29	polymyxin b32	7.6	SELE, VCAM1, ITGB2, IL1A, IL1RN, IL4
30	atp32	7.6	PIK3C2A, NCAM1, MYBPC1, CLU, CHKA, CHKB
31	superoxide32 18	8.6	PIK3C2A, SERPINA3, VCAM1, CLU, CHKA, CHKB
32	cholesterol32 9 18 9	10.5	PIK3C2A, VWF, SFTPD, SELE, SERPINA3, VCAM1
33	lipid32	7.5	PIK3C2A, NCAM1, SFTPD, SELE, SERPINA3, VCAM1
34	polyinosinic-polycytidylic acid32	7.3	SELE, VCAM1, CD40, IL15, IL1A, IL4
35	vegf32	7.2	PIK3C2A, NCAM1, CNTN2, VWF, SELE, VCAM1
36	creatinine32	7.2	PIK3C2A, NCAM1, VWF, SELE, SERPINA3, UTRN
37	ly29400232	7.1	PIK3C2A, SELE, VEGFA, JUN, ITGB2, GZMB
38	herbimycin a32 42	8.1	SELE, VCAM1, JUN, CD28, CD40, ITGB2
39	paraffin32	7.1	NCAM1, VWF, SERPINA3, VEGFA, VCAM1, CLU
40	thymidine32 18	8.0	CNTN2, SFTPD, CLU, CHKA, CHKB, JUN
41	alanine32	6.9	PIK3C2A, NCAM1, CNTN2, VWF, SELE, SERPINA3
42	il 1032	6.5	CD8A, CD40, IL15, IL1A, IL1RAPL2, IL1RN
43	lactate32	6.4	PIK3C2A, NCAM1, VWF, SFTPD, SELE, VCAM1
44	infliximab32 9 9	8.2	SELE, VEGFA, ITGA4, IL15, IL17A, IL1RAPL2
45	genistein32 9 18 9	9.2	SELE, VEGFA, VCAM1, CHKA, JUN, CD28
46	rantes32	6.0	SELE, VCAM1, JUN, CD40, ITGA4, ITGB2
47	retinoic acid32 42 18	7.6	NCAM1, CNTN2, VWF, SERPINA3, VCAM1, CLU
48	simvastatin32 34 42 9 18 9	10.5	PIK3C2A, VWF, SELE, VEGFA, VCAM1, CHKA
49	actinomycin d32	4.9	SELE, VEGFA, CLU, JUN, CD40, IL17A
50	tyrosine32	4.7	PIK3C2A, NCAM1, CNTN2, VWF, VEGFA, VCAM1

Cellular components related to polymyositis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	nuclear exosome (RNase complex)	GO:000176	10.5	EXOSC9, EXOSC10, C1D
2	exosome (RNase complex)	GO:000178	10.4	EXOSC10, EXOSC9, EXOSC5, EXOSC2
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.8	HLA-DQB1, HLA-A, HLA-DRB1, HLA-B, HLA-DQA1
4	sarcolemma	GO:042383	9.7	DES, DMD, ALOX5, LAMA2, VCAM1, KRT19
5	ER to Golgi transport vesicle membrane	GO:012507	9.6	HLA-B, HLA-DQA1, HLA-A, HLA-DRB1, HLA-DQB1
6	cytosol	GO:005829	9.3	IARS, ALOX5, HSP90AA1, CARS, EXOSC2, EXOSC5
7	cell surface	GO:009986	9.0	HMGB1, CCR5, TNFRSF4, DMD, TLR2, CNTN2
8	integral to plasma membrane	GO:005887	8.1	CD28, CNTN2, CTLA4, CD8A, CD163, CD40
9	plasma membrane	GO:005886	7.5	HLA-B, HLA-A, HSP90AA1, HSPG2, ICAM1, CCR7
10	external side of plasma membrane	GO:009897	7.0	FASLG, IL4, IL17A, ITGA4, CD40, CD274
11	extracellular region	GO:005576	6.5	CD8A, NCAM1, FASLG, IL1A, IL15, GZMA
12	extracellular space	GO:005615	6.0	CCL2, CCL3, CCL21, CCL19, IFNA2, IFNB1

Biological processes related to polymyositis according to GeneDecks:

(show top 50)    (show all 63)

id	Name	GO ID	Score	Top Affiliating Genes
1	tRNA aminoacylation for protein translation	GO:006418	10.9	KARS, CARS, GARS, IARS, FARSA, TARS
2	positive regulation of interleukin-2 biosynthetic process	GO:045086	10.8	CD80, CD86, CD28, IL1A
3	dendritic cell chemotaxis	GO:002407	10.7	CCR5, CCL21, HMGB1, CCL19, CCR7
4	negative regulation of leukocyte apoptotic process	GO:2000107	10.5	CCR7, CCL19, CCL21
5	muscle filament sliding	GO:030049	10.5	NEB, DES, TTN, DMD, TNNI3, MYBPC1
6	establishment of T cell polarity	GO:001768	10.4	CCL21, CCL19, CCR7
7	leukocyte cell-cell adhesion	GO:007159	10.4	ICAM1, CALCA, ITGB2, SELE, ITGA4, VCAM1
8	gene expression	GO:010467	10.3	EXOSC5, CARS, TARS, LSM2, RPS27A, EXOSC2
9	T cell costimulation	GO:031295	10.1	CD274, CTLA4, CD80, HLA-DQB1, CD28, MAPKAP1
10	aging	GO:007568	10.0	FAS, PTGS1, HMGCR, CALCA, CCL2, JUN
11	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.9	TNF, CCL19, CCL21, CCR7, TLR4, IL1A
12	positive regulation of JNK cascade	GO:046330	9.9	IL1A, CCL21, TNF, TLR4, TLR9, CCR7
13	cell-cell signaling	GO:007267	9.8	CALCA, CCL21, CCL3, CCR5, IL17A, SST
14	positive regulation of inflammatory response	GO:050729	9.8	TLR9, IL15, CCL3, TLR4, TLR2
15	positive regulation of nitric-oxide synthase biosynthetic process	GO:051770	9.8	CCL2, TLR2, TLR4, TLR9
16	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.7	IL1A, CCL21, FASLG, CCL19, TNF, RPS27A
17	response to lipopolysaccharide	GO:032496	9.7	PTGS2, CCR7, S100A8, FAS, JUN, SELE
18	regulation of immune response	GO:050776	9.7	CD40, HLA-B, HLA-A, IL4, ITGB2, ITGA4
19	positive regulation of interferon-beta production	GO:032728	9.6	TLR9, TLR4, TLR2, IFIH1
20	response to nutrient	GO:007584	9.6	ALOX5, HMGCR, SST, VCAM1, IL4, LTA
21	defense response to virus	GO:051607	9.6	IFNB1, EXOSC5, CD40, IFNG, CD86, MICA
22	positive regulation of NF-kappaB import into nucleus	GO:042346	9.6	TLR4, TLR2, TNF, CCL19, TLR9
23	positive regulation of interleukin-6 production	GO:032755	9.5	TNF, IL1A, TLR2, TLR4, TLR9
24	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.5	CLU, TLR2, CD40, TLR9, TNF, ICAM1
25	positive regulation of interleukin-8 production	GO:032757	9.5	TLR2, TLR9, CALCA, TLR4
26	positive regulation of chemokine production	GO:032722	9.5	TLR4, TLR9, TNF, TLR2
27	negative regulation of osteoclast differentiation	GO:045671	9.4	IL4, CCL3, CALCA, TLR4
28	response to organic cyclic compound	GO:014070	9.4	MSH2, IL1RN, JUN, IL1A, IL4, CCL19
29	lipopolysaccharide-mediated signaling pathway	GO:031663	9.4	TLR4, CCL2, CCL3, TNF, TLR2
30	cellular response to lipopolysaccharide	GO:071222	9.3	CCL2, ICAM1, CCR5, IFNG, TNFRSF1B, TLR4
31	negative regulation of interleukin-17 production	GO:032700	9.3	TLR4, PRNP, TLR2, IFNG
32	positive regulation of T cell proliferation	GO:042102	9.3	VCAM1, CD28, IL15, IL4, CCL19, IFNG
33	interferon-gamma-mediated signaling pathway	GO:060333	9.3	HLA-DQA1, NCAM1, HLA-A, HLA-B, VCAM1, IFNG
34	positive regulation of interleukin-12 production	GO:032735	9.3	TLR2, CCR7, CCL19, IFNG, TLR4, TLR9
35	positive regulation of tumor necrosis factor production	GO:032760	9.2	TLR9, TLR2, IFNG, CCL3, CCL19, TLR4
36	response to ethanol	GO:045471	9.1	S100A8, S100A9, IL4, ICAM1, CCL2, TLR4
37	positive regulation of apoptotic process	GO:043065	9.1	FAS, TNF, HMGB1, FASLG, GZMA, CLU
38	cell surface receptor signaling pathway	GO:007166	9.0	CD274, IFNA2, SST, CCR5, CCL2, IL2RA
39	humoral immune response	GO:006959	9.0	IFNB1, IFNG, TNF, LTA, CD28, CCL2
40	negative regulation of growth of symbiont in host	GO:044130	9.0	TLR2, IFNG, TNF, LTA
41	innate immune response	GO:045087	8.9	IFNB1, IFNA2, HMGB1, C2, TLR2, RPS27A
42	response to glucocorticoid stimulus	GO:051384	8.8	PTGS2, TNF, HMGB1, CCL2, FAS, IL1RN
43	cytokine-mediated signaling pathway	GO:019221	8.7	RPS27A, IFNB1, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
44	response to hypoxia	GO:001666	8.6	VCAM1, IL1A, FAS, CCL2, TNF, CRP
45	positive regulation of nitric oxide biosynthetic process	GO:045429	8.5	IFNG, ICAM1, HSP90AA1, TNF, TLR2, PTGS2
46	apoptotic process	GO:006915	8.3	IL17A, IL1A, IL2RA, RPS27A, IFNG, SQSTM1
47	immune response	GO:006955	8.3	CD86, CD8A, CD274, GZMA, EXOSC9, HLA-A
48	inflammatory response	GO:006954	8.1	CD180, CALCA, TNF, TNFRSF1B, TNFRSF4, PTGS2
49	response to drug	GO:042493	7.5	IFNG, JUN, IL1RN, IL4, FAS, CCL2
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.2	TNF, IL1A, SQSTM1, TLR9, TLR4, IL4

Molecular functions related to polymyositis according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:015026	10.4	CD28, CD86, CD8A, CD80, CCR5
2	exoribonuclease activity	GO:004532	10.4	EXOSC2, EXOSC5, EXOSC9, EXOSC10
3	tRNA binding	GO:000049	10.2	AARS, KARS, CARS, FARSA, SSB
4	structural constituent of muscle	GO:008307	10.1	MYBPC1, NEB, TTN, DMD, KRT19
5	receptor binding	GO:005102	8.8	UCN2, CCL2, NPY, HLA-B, LTA, CALCA
6	cytokine activity	GO:005125	7.5	IFNB1, VEGFA, IL15, IL17A, IL1A, IL4
7	protein binding	GO:005515	4.7	CD59, FAS, CCR5, CCL3, IFIH1, IFNA2