PM
MCID: PLY041
MIFTS: 54

Polymyositis (PM) malady

Neuronal diseases, Nephrological diseases, Bone diseases categories

Summaries for Polymyositis

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42NIH Rare Diseases, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.  polymyositis affects skeletal muscles (those involved with making movement) on both sides of the body.  it is rarely seen in persons under age 18; most cases are seen in adults between the ages of 31 and 60. the cause of polymyositis is not fully understood. although there's no cure for polymyositis, treatment can improve muscle strength and function. last updated: 4/22/2009

MalaCards: Polymyositis, also known as adult-onset polymyositis, is related to dermatomyositis and myositis, and has symptoms including venous thrombosis/phlebitis/thrombophlebitis, heart/cardiac failure and angor pectoris/myocardial infarction. An important gene associated with Polymyositis is HARS (histidyl-tRNA synthetase), and among its related pathways are Generic Transcription Pathway and tRNA Aminoacylation. The compounds calcium and cysteine have been mentioned in the context of this disorder. Affiliated tissues include lung, skeletal muscle and heart, and related mouse phenotype hematopoietic system.

NINDS:43 Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.

Wikipedia:63 Polymyositis (PM)(\"inflammation of many muscles\") is a type of chronic inflammation of the muscles... more...

Description from OMIM:46 160750

Aliases & Classifications for Polymyositis

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42NIH Rare Diseases, 43NINDS, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

48
polymyositis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

polymyositis 42 43 44 48 46 60
adult-onset polymyositis 48
pm 48


External Ids:

MESH via Orphanet35 D017285
ICD10 via Orphanet26 M33.2
SNOMED-CT via Orphanet57 31384009
UMLS via Orphanet61 C0085655
OMIM46 160750
ICD1025 M33.2

Related Diseases for Polymyositis

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17GeneCards, 18GeneDecks
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Diseases related to Polymyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1dermatomyositis31.5GARS, TARS, CD59, CD40, CHKB, CHKA
2myositis30.9HARS, MB, GZMA, PIK3C2A, CHKA, GARS
3interstitial lung disease30.8HARS, SFTPD
4myopathy30.6CD59, CHKB, CHKA, PIK3C2A, MB, GARS
5pneumonia30.6CD40, PIK3C2A, SFTPD, MB, IL17A
6arthritis30.5CD59, CCR7, MB, IL15, IL17A
7rheumatoid arthritis30.5IL17A, RNPC3, CD40, CNTN2, IL15, CHKB
8myocarditis30.3CHKB, MB
9connective tissue disease30.3CD40
10systemic lupus erythematosus30.2CCR7, CD40, IL15, RNPC3, IL17A, CD59
11leukemia30.2CCR7, CD59, IL15, CD40, GZMA, CNTN2
12myasthenia gravis30.1IL15
13bronchiolitis obliterans30.0IL17A
14adenocarcinoma30.0CD59, SFTPD, CHKA
15respiratory failure30.0SFTPD, PIK3C2A
16tuberculosis29.9SFTPD, IL17A, CCR7
17sjogren's syndrome29.9CD40, GZMA, RNPC3
18sarcoidosis29.9SFTPD, IL15
19influenza29.9MB, RNPC3, CCR7, SFTPD
20hepatitis c29.9RNPC3, IL15
21hepatitis b29.9RNPC3
22eosinophilia29.9PIK3C2A, MB
23tropical spastic paraparesis29.9CNTN2, IL15
24osteoarthritis29.8IL17A, CD59, GZMA, IL15
25ischemic heart disease29.8MB, CHKB, PIK3C2A
26dermatitis29.7PIK3C2A, HARS, IL17A
27acute myocardial infarction29.7PIK3C2A, CHKA, CHKB, CD40, MB
28ovarian cancer29.7CHKA, CCR7, IL15, CD59, CD40
29myocardial infarction29.7CHKA, PIK3C2A, MB, CD59, CHKB
30duchenne muscular dystrophy29.7MB, PIK3C2A, CHKB
31autoimmune thyroiditis29.7CHKB, CD40, CD59
32gastritis29.7CD59, SFTPD, IL17A
33inclusion body myositis10.5
34scleroderma10.4
35adult dermatomyositis10.4
36hepatitis10.3
37premenstrual tension10.2
38lupus erythematosus10.2
39mixed connective tissue disease10.2
40hypothyroidism10.2
41thymoma10.2
42autoimmune hepatitis10.1
43glomerulonephritis10.1
44muscular dystrophy10.1
45vasculitis10.1
46childhood type dermatomyositis10.1
47breast cancer10.1
48hypertension10.1
49systemic scleroderma10.1
50graft versus host disease10.0

Graphical network of the top 20 diseases related to Polymyositis:



Diseases related to polymyositis

Clinical Features for Polymyositis

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46OMIM, 48Orphanet
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Clinical features from OMIM:

160750

Clinical synopsis from OMIM:

160750

Symptoms:

48 (show all 40)
  • venous thrombosis/phlebitis/thrombophlebitis
  • heart/cardiac failure
  • angor pectoris/myocardial infarction
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • cardiac rhythm disorder/arrhythmia
  • periarticular tissue anomaly/extraarticular calcifications
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • vascularitis/vasculitides/arteritis
  • renal tubular defect/tubulopathy
  • abnormal gait
  • areflexia/hyporeflexia
  • elocution disorders/dysarthria/dysphonia
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • breast neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • abnormal emg/electromyogram/electropmyography
  • cardiomyopathy/hypertrophic/dilated
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • constipation
  • autoimmunity/autoimmune reaction/autoantibodies
  • articular/joint pain/arthralgia
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • myalgia/muscular pain
  • muscle weakness/flaccidity
  • hypotonia
  • anorexia
  • arthritis/synovitis/synovial proliferation
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • abnormal cry/voice/phonation disorder/nasal speech
  • lung fibrosis
  • hepatomegaly/liver enlargement (excluding storage disease)
  • intestinal perforation
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • acute abdominal pain/colic
  • gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
  • asthenia/fatigue/weakness
  • fever/chilling
  • cough

Drugs & Therapeutics for Polymyositis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Polymyositis

Drug clinical trials:

Search ClinicalTrials for Polymyositis

Search NIH Clinical Center for Polymyositis

Search CenterWatch for Polymyositis

Genetic Tests for Polymyositis

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Anatomical Context for Polymyositis

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32MalaCards
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MalaCards organs/tissues related to Polymyositis:

32
Lung, Skeletal muscle, Heart, Bone, Ovary, Liver, Breast

Animal Models for Polymyositis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polymyositis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.7IL17A, IL15, CD59, CD40, PIK3C2A, MB

Publications for Polymyositis

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Genetic Variations for Polymyositis

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Expression for genes affiliated with Polymyositis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polymyositis

Search GEO for disease gene expression data for Polymyositis.

Pathways for genes affiliated with Polymyositis

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53Reactome, 29KEGG
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Pathways related to Polymyositis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6KARS, HARS, GARS, IARS, TARS, EXOSC9
2
Hide members
10.6TARS, IARS, GARS, HARS, KARS

Compounds for genes affiliated with Polymyositis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Polymyositis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.2CCR7, CHKA, GARS, CNTN2, CD40, CD59
2cysteine4411.1CNTN2, CHKB, GARS, CHKA, IL15, CD40
3tyrosine4411.1CNTN2, CCR7, CHKA, IL17A, IL15, RNPC3
4alanine4411.1CHKA, GARS, PIK3C2A, IL15, CNTN2, CHKB
5cyclosporin a44 28 5913.1CNTN2, IL15, RNPC3, CD59, CD40, GZMA
6steroid4411.1SFTPD, IL17A, PIK3C2A, IL15, CD40, CNTN2
7oxygen44 2412.1SFTPD, CD59, CD40, PIK3C2A, MB, CNTN2
8glutamate4411.1CNTN2, MB, CD40, CHKB, CHKA, KARS
9phosphatidylinositol4411.1CD59, CD40, CCR7, SFTPD, PIK3C2A, CHKA
10thymidine44 2412.1IL15, IL17A, CD40, SFTPD, CHKA, CNTN2
11Adenosine triphosphate11 2412.1TARS, IARS, CHKB, KARS, HARS, GARS
12superoxide44 2412.0CD59, PIK3C2A, GZMA, IL15, CHKA, CD40
13creatinine4411.0MB, CD40, PIK3C2A, CHKA, CHKB, IL15
14trna4411.0RNPC3, KARS, TARS, GARS, IARS
15pyrophosphate44 2412.0TARS, KARS, HARS, GARS, PIK3C2A, IARS
16serine4411.0GARS, TARS, RNPC3, CHKA, KARS, MB
17atorvastatin44 49 28 11 2415.0CD59, CHKB, CHKA, CD40, PIK3C2A
18prednisolone44 28 1113.0SFTPD, CD40, PIK3C2A, MB, CHKB
19phosphocreatine44 2412.0MB, CHKB, CHKA, PIK3C2A
20alpha-hydroxybutyrate4411.0PIK3C2A, MB, CHKB
21ionomycin4411.0GZMA, IL15, IL17A, CD40, CNTN2
22tacrolimus44 49 1113.0IL15, CD40, IL17A, CCR7, CHKB
23vegf4411.0MB, CD40, CNTN2, CHKB, PIK3C2A, IL15
24lactate4411.0SFTPD, MB, CHKA, PIK3C2A, CHKB, CD59
25fluvastatin44 49 28 1113.9PIK3C2A, CD40, CHKB, MB
26methotrexate44 49 1112.9IL17A, CD40, IL15, CHKB, PIK3C2A
27zinc44 2411.9CD40, RNPC3, GARS, TARS, CNTN2, CHKB
28dantrolene44 28 1112.9PIK3C2A, MB, CHKB
29succinylcholine44 28 1112.9CHKB, MB, PIK3C2A
30leucine4410.9KARS, SFTPD, GARS, CHKB, CNTN2, RNPC3
31lipid4410.9CD40, IL17A, CD59, SFTPD, IL15, CHKA
32gamma-hydroxybutyrate4410.9CHKB, PIK3C2A, MB
33anticodon4410.9KARS, TARS, GARS
34rantes4410.9CCR7, IL17A, CD40, GZMA, IL15
35Adenosine monophosphate11 2411.9HARS, GARS, IARS, TARS, KARS
36pravastatin44 49 28 11 2414.9PIK3C2A, CHKA, CD40, CHKB
37phosphoric acid44 2411.9KARS, HARS, GARS, IARS, TARS
38pge24410.8MB
39adenylate4410.8CHKB, IL15, RNPC3, MB, CD40, CHKA
40atp44 2811.8RNPC3, GARS, PIK3C2A, IARS, CHKB, CHKA
41lovastatin44 49 59 28 1114.8CD40, CHKA, PIK3C2A, CHKB
42aminoacyl-trna4410.8IARS, KARS, GARS
43gemfibrozil44 28 1112.7CHKB, CHKA, PIK3C2A
44citrate4410.7CHKA, PIK3C2A, CHKB, MB
45cyclocreatine4410.7CHKB, CHKA
46cholesterol44 28 11 2413.6CHKA, CHKB, CD40, CD59, PIK3C2A, SFTPD
47glycogen44 2411.6PIK3C2A, CHKB, CHKA
48cerivastatin44 49 28 1113.5PIK3C2A, CHKB, CD40
49simvastatin44 49 59 28 11 2415.5CHKA, CD40, PIK3C2A, CHKB
50choline44 11 2412.3CNTN2, PIK3C2A, CHKA, CHKB

GO Terms for genes affiliated with Polymyositis

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16Gene Ontology
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Cellular components related to Polymyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1exosome (RNase complex)GO:00017810.5EXOSC10, EXOSC9
2nuclear exosome (RNase complex)GO:00017610.4EXOSC10, EXOSC9
3cytosolGO:00582910.4EXOSC9, KARS, HARS, GARS, PIK3C2A, CHKA

Biological processes related to Polymyositis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1tRNA aminoacylation for protein translationGO:00641810.8TARS, IARS, GARS, HARS, KARS
2gene expressionGO:01046710.7EXOSC9, KARS, HARS, GARS, IARS, TARS
3immune responseGO:00695510.7CCR7, EXOSC9, GZMA, IL15, IL17A
4nuclear polyadenylation-dependent rRNA catabolic processGO:07103510.7EXOSC9, EXOSC10
5diadenosine tetraphosphate biosynthetic processGO:01596610.7KARS, GARS
6nuclear mRNA surveillanceGO:07102810.6EXOSC10, EXOSC9
7CDP-choline pathwayGO:00665710.5CHKA, CHKB
8phosphatidylethanolamine biosynthetic processGO:00664610.5CHKB, CHKA
9nuclear-transcribed mRNA catabolic processGO:00095610.4EXOSC9, EXOSC10
10inflammatory responseGO:00695410.3IL17A, IL15, CD40, CCR7

Molecular functions related to Polymyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00552410.6KARS, HARS, GARS, PIK3C2A, CHKA, CHKB
2choline kinase activityGO:00410310.5CHKB, CHKA
3exoribonuclease activityGO:00453210.5EXOSC10, EXOSC9
4ethanolamine kinase activityGO:00430510.2CHKB, CHKA

Products for genes affiliated with Polymyositis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polymyositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet