PM
MCID: PLY041
MIFTS: 59

Polymyositis (PM) malady

Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases categories
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Summaries for Polymyositis

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NIH Rare Diseases:42 Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.  polymyositis affects skeletal muscles (those involved with making movement) on both sides of the body.  it is rarely seen in persons under age 18; most cases are seen in adults between the ages of 31 and 60. the cause of polymyositis is not fully understood. although there's no cure for polymyositis, treatment can improve muscle strength and function. last updated: 4/22/2009

MalaCards based summary: Polymyositis, also known as PM, is related to interstitial lung disease and myositis, and has symptoms including cough, hypotonia and muscle weakness/flaccidity. An important gene associated with Polymyositis is HARS (histidyl-tRNA synthetase), and among its related pathways are Th17 Differentiation and tRNA Aminoacylation. The compounds anticodon and hydroxylysine have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and skeletal muscle.

NINDS:43 Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.

Wikipedia:65 Polymyositis (PM)(\"inflammation of many muscles\") is a type of chronic inflammation of the muscles... more...

Aliases & Classifications for Polymyositis

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Sources:
42NIH Rare Diseases, 43NINDS, 44Novoseek, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
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Polymyositis, Aliases & Descriptions:

Name: Polymyositis 42 43 44 48 62
 
Pm 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
polymyositis:
Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


External Ids:

MESH via Orphanet35 D017285
ICD10 via Orphanet26 M33.2
UMLS via Orphanet63 C0085655
ICD1025 M33.2

Related Diseases for Polymyositis

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Diseases related to Polymyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1interstitial lung disease31.3SFTPD, HARS
2myositis31.3GARS, HARS, CHKB
3myopathy30.6CD59, GARS, CHKB
4dermatomyositis30.5SFTPD, CHKB, CCR7, IL17A, GARS, CD59
5arthritis30.2CCR7, IL17A, CD59
6systemic lupus erythematosus30.0CD59, IL17A, CCR7
7tuberculosis29.9IL17A, SFTPD, CCR7
8autoimmune thyroiditis29.7CD59, CHKB
9gastritis29.5IL17A, CD59, SFTPD
10leukemia29.4CD59, CNTN2, IL17A, CCR7
11rheumatoid arthritis29.3CHKB, CCR7, SFTPD, CD59, CNTN2, IL17A
12inclusion body myositis10.6
13pneumonia10.5
14scleroderma10.4
15hepatitis10.4
16myocarditis10.3
17connective tissue disease10.3
18lupus erythematosus10.3
19thymoma10.3
20mixed connective tissue disease10.2
21autoimmune hepatitis10.2
22glomerulonephritis10.2
23myasthenia gravis10.2
24hypothyroidism10.2
25muscular dystrophy10.2
26vasculitis10.2
27childhood type dermatomyositis10.1
28hypertension10.1
29adult dermatomyositis10.1
30breast cancer10.1
31amyopathic dermatomyositis10.1
32bronchiolitis obliterans10.1
33graft versus host disease10.1
34hepatocellular carcinoma10.1
35primary biliary cirrhosis10.1
36bronchiolitis10.1
37bronchiolitis obliterans organizing pneumonia10.1
38pemphigus10.1
39polyarteritis nodosa10.1
40adenocarcinoma10.1
41fasciitis10.1
42intestinal pseudo-obstruction10.1
43pancreatitis10.1
44purpura10.1
45respiratory failure10.1
46thymic carcinoma10.1
47thyroiditis10.1
48antisynthetase syndrome10.1
49paraneoplastic syndromes10.1
50endotheliitis10.1

Graphical network of the top 20 diseases related to Polymyositis:



Diseases related to polymyositis

Symptoms for Polymyositis

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Symptoms:

48 (show all 40)
  • cough
  • hypotonia
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • abnormal emg/electromyogram/electropmyography
  • articular/joint pain/arthralgia
  • autoimmunity/autoimmune reaction/autoantibodies
  • constipation
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • anorexia
  • arthritis/synovitis/synovial proliferation
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness
  • gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal perforation
  • hepatomegaly/liver enlargement (excluding storage disease)
  • lung fibrosis
  • abnormal cry/voice/phonation disorder/nasal speech
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • cardiomyopathy/hypertrophic/dilated
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cardiac rhythm disorder/arrhythmia
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • angor pectoris/myocardial infarction
  • heart/cardiac failure
  • venous thrombosis/phlebitis/thrombophlebitis
  • vascularitis/vasculitides/arteritis
  • renal tubular defect/tubulopathy
  • abnormal gait
  • areflexia/hyporeflexia
  • elocution disorders/dysarthria/dysphonia
  • periarticular tissue anomaly/extraarticular calcifications
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • breast neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)

HPO human phenotypes related to Polymyositis:

(show all 34)
id Description Frequency HPO Source Accession
1 muscular hypotonia hallmark (90%) HP:0001252
2 muscle weakness hallmark (90%) HP:0001324
3 arthralgia hallmark (90%) HP:0002829
4 autoimmunity hallmark (90%) HP:0002960
5 myalgia hallmark (90%) HP:0003326
6 emg abnormality hallmark (90%) HP:0003457
7 arthritis typical (50%) HP:0001369
8 weight loss typical (50%) HP:0001824
9 constipation typical (50%) HP:0002019
10 anorexia typical (50%) HP:0002039
11 restrictive lung disease typical (50%) HP:0002091
12 respiratory insufficiency typical (50%) HP:0002093
13 abnormality of temperature regulation typical (50%) HP:0004370
14 abnormality of the renal tubule occasional (7.5%) HP:0000091
15 chondrocalcinosis occasional (7.5%) HP:0000934
16 gait disturbance occasional (7.5%) HP:0001288
17 reduced tendon reflexes occasional (7.5%) HP:0001315
18 abnormality of the voice occasional (7.5%) HP:0001608
19 abnormality of the mitral valve occasional (7.5%) HP:0001633
20 congestive heart failure occasional (7.5%) HP:0001635
21 hypertrophic cardiomyopathy occasional (7.5%) HP:0001639
22 coronary artery disease occasional (7.5%) HP:0001677
23 abnormality of the pericardium occasional (7.5%) HP:0001697
24 abdominal pain occasional (7.5%) HP:0002027
25 neurological speech impairment occasional (7.5%) HP:0002167
26 pulmonary fibrosis occasional (7.5%) HP:0002206
27 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
28 hepatomegaly occasional (7.5%) HP:0002240
29 vasculitis occasional (7.5%) HP:0002633
30 thrombophlebitis occasional (7.5%) HP:0004418
31 arrhythmia occasional (7.5%) HP:0011675
32 neoplasm of the breast occasional (7.5%) HP:0100013
33 neoplasm of the lung occasional (7.5%) HP:0100526
34 ovarian neoplasm occasional (7.5%) HP:0100615

Drugs & Therapeutics for Polymyositis

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Drug clinical trials:

Search ClinicalTrials for Polymyositis

Search NIH Clinical Center for Polymyositis

Genetic Tests for Polymyositis

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Anatomical Context for Polymyositis

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MalaCards organs/tissues related to Polymyositis:

32
Lung, T cells, Skeletal muscle, Heart, Breast, Liver, Bone, Ovary, Testes, Monocytes, Thyroid, Skin, Endothelial, Colon, Myeloid, B cells, Tongue, Small intestine, Kidney, Pancreas, Adrenal gland, Placenta, Pituitary, Neutrophil

Animal Models for Polymyositis or affiliated genes

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Publications for Polymyositis

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Articles related to Polymyositis:

(show top 50)    (show all 658)
idTitleAuthorsYear
1
High-dose subcutaneous immunoglobulins for the treatment of severe treatment-resistant polymyositis. (25140268)
2014
2
Increased subsequent risk of acute coronary syndrome for patients with dermatomyositis/polymyositis: a nationwide population-based retrospective cohort study. (25205256)
2014
3
Cutaneous tuberculous gummas in a patient with polymyositis. (23539011)
2013
4
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? (23358869)
2013
5
Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: a randomized, placebo-phase trial. (23124935)
2013
6
A case of polymyositis associated with Hashimoto's thyroiditis. (23682237)
2013
7
The high prevalence of metabolic syndrome in polymyositis. (24144101)
2013
8
Marked increase in serum KL-6 and surfactant proteinA D levels during the first 4A weeks after treatment predicts poor prognosis in patients with active interstitial pneumonia associated with polymyositis/dermatomyositis. (22983659)
2013
9
Age at onset and gender distribution of systemic lupus erythematosus, polymyositis/dermatomyositis, and systemic sclerosis in Japan. (22903259)
2013
10
Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine. (22284862)
2012
11
Polymyositis. (22422831)
2012
12
Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis. (21881594)
2012
13
Prevalence of clinical and laboratory manifestations and comorbidities in polymyositis according to gender. (21952995)
2011
14
Abatacept for treatment of refractory polymyositis. (21550833)
2011
15
IV immunoglobulin might be considered as a first-line treatment of severe interstitial lung disease associated with polymyositis. (21813543)
2011
16
Nerve conduction studies in patients with dermatomyositis or polymyositis. (20367974)
2010
17
Increased serum concentration of immune cell derived microparticles in polymyositis/dermatomyositis. (20043950)
2010
18
Lymphoma-associated polymyositis in dogs. (19780930)
2009
19
Malignancies associated with dermatomyositis and polymyositis in Taiwan: a nationwide population-based study. (19558555)
2009
20
Thoracic epidural anesthesia for a polymyositis patient undergoing awake mini-thoracotomy and unroofing of a huge pulmonary bulla. (18390401)
2008
21
Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis. (18821695)
2008
22
Intestinal pseudo-obstruction associated with polymyositis successfully treated with somatostatin analog]. (18323156)
2008
23
Autoantibody to signal recognition particle in African American girls with juvenile polymyositis. (18322984)
2008
24
Recurrent placental massive perivillous fibrin deposition associated with polymyositis: a case report and review of the literature. (17990939)
2008
25
Flow cytometric analysis of lymphocyte subpopulations and TH1/TH2 balance in patients with polymyositis and dermatomyositis. (18797118)
2008
26
Polymyositis and pemphigus vulgaris in a patient: successful treatment with rituximab. (18455465)
2008
27
Disease-specific quality indicators, outcome measures and guidelines in polymyositis and dermatomyositis. (18021522)
2007
28
A rare case of systemic autoimmune disease with intricate features of systemic sclerosis, lupus, polymyositis and rheumatoid arthritis. Overlap syndrome or mixed connective tissue disease? (17932479)
2007
29
Prognosis of polymyositis and dermatomyositis. (16642405)
2007
30
Malignant thymoma associated with fatal myocarditis and polymyositis in a 32-year-old woman with a history of hairy cell leukemia. (16601447)
2006
31
CD8-positive T cell-induced liver damage was found in a patient with polymyositis. (17043378)
2006
32
Pseudoxanthoma elasticum and polymyositis in a child. (16428004)
2006
33
Steroid-responsive subacute polymyositis in an adult following respiratory syncytial virus infection. (16409434)
2006
34
A case of polymyositis with concomitant diffuse alveolar damage following interstitial pneumonia]. (17233391)
2006
35
Long-term persistence of clonally expanded T cells in patients with polymyositis. (15514965)
2004
36
Polymyositis: an ongoing discussion about a disease entity. (14732633)
2004
37
Polymyositis associated with HIV infection during immune restoration induced by highly active anti-retroviral therapy. (15485025)
2004
38
Polymyositis induced or associated with lipid-lowering drugs: five cases]. (15050796)
2004
39
PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome. (14872500)
2004
40
Immunolocalization of protectin (CD59) and macrophages in polymyositis and dermatomyositis. (15020079)
2004
41
Efficacy of tacrolimus in treatment of polymyositis associated with myasthenia gravis. (15168159)
2004
42
Critical requirement for professional APCs in eliciting T cell responses to novel fragments of histidyl-tRNA synthetase (Jo-1) in Jo-1 antibody-positive polymyositis. (12471150)
2002
43
Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. (10638867)
2000
44
Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis. (11055823)
2000
45
Benefit of 6 months long-term physical training in polymyositis/dermatomyositis patients. (9973161)
1998
46
Onset of polymyositis with autoantibodies to threonyl-tRNA synthetase during pregnancy. (7983666)
1994
47
Relationship of cancer to inflammatory muscle diseases. Dermatomyositis, polymyositis, and inclusion body myositis. (7855330)
1994
48
Degradative activity of granzyme A on skeletal muscle proteins in vitro: a possible molecular mechanism for muscle fiber damage in polymyositis. (8268727)
1993
49
Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome. (2308937)
1990
50
Polymyositis in eosinophilic fasciitis. Review and case report. (7389757)
1980

Variations for Polymyositis

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Expression for genes affiliated with Polymyositis

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Expression patterns in normal tissues for genes affiliated with Polymyositis

Search GEO for disease gene expression data for Polymyositis.

Pathways for genes affiliated with Polymyositis

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Pathways related to Polymyositis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4CCR7, IL17A
2
Show member pathways
9.3HARS, KARS, IARS, GARS
3
Show member pathways
8.5GARS, HARS, KARS, IARS, EXOSC9

Compounds for genes affiliated with Polymyositis

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Compounds related to Polymyositis according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1anticodon4410.2KARS, GARS
2hydroxylysine4410.1SFTPD, CHKB
3aminoacyl-trna4410.0GARS, KARS, IARS
4trna449.9IARS, KARS, GARS
5fitc449.7CCR7, CD59
6mannan449.7IL17A, SFTPD
7Adenosine monophosphate24 1110.7HARS, KARS, IARS, GARS
8phosphoric acid44 2410.7KARS, HARS, IARS, GARS
9pyrophosphate44 2410.7GARS, IARS, KARS, HARS
10nickel44 2410.6CCR7, IL17A
11latex449.6CNTN2, CCR7, CHKB
12ccl444 2810.4IL17A, CCR7
13endotoxin449.4IL17A, SFTPD, CHKB
14tacrolimus44 50 1111.4CHKB, CCR7, IL17A
15Adenosine triphosphate24 1110.3KARS, CHKB, IARS, GARS, HARS
16phospholipid449.2SFTPD, CHKB, CD59
17glutamate449.2KARS, CHKB, CNTN2, GARS
18leucine449.1GARS, SFTPD, KARS, CHKB, CNTN2
19alanine449.0CHKB, CNTN2, GARS, CCR7, KARS
20cysteine449.0GARS, CHKB, SFTPD, KARS, CNTN2
21thymidine44 2410.0SFTPD, CNTN2, IL17A, CHKB
22steroid448.9CHKB, IL17A, SFTPD, CNTN2
23cyclosporin a44 28 6110.8CHKB, IL17A, CNTN2, CD59
24phosphatidylinositol448.8CD59, IL17A, CCR7, SFTPD
25atp44 289.7CD59, CHKB, GARS, IARS
26oxygen44 249.7CD59, CHKB, CNTN2, SFTPD
27tyrosine448.2GARS, CCR7, IL17A, CNTN2, CD59
28calcium44 50 24 1111.1SFTPD, GARS, KARS, CCR7, CNTN2, CD59

GO Terms for genes affiliated with Polymyositis

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Cellular components related to Polymyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear exosome (RNase complex)GO:0001769.0EXOSC9, EXOSC10
2exosome (RNase complex)GO:0001788.8EXOSC9, EXOSC10
3cytosolGO:0058298.1KARS, CHKB, IARS, EXOSC9, GARS, HARS

Biological processes related to Polymyositis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1diadenosine tetraphosphate biosynthetic processGO:01596610.0GARS, KARS
2tRNA aminoacylation for protein translationGO:0064189.5HARS, GARS, IARS, KARS
3nuclear polyadenylation-dependent rRNA catabolic processGO:0710359.3EXOSC9, EXOSC10
4nuclear mRNA surveillanceGO:0710289.1EXOSC9, EXOSC10
5nuclear-transcribed mRNA catabolic processGO:0009569.0EXOSC9, EXOSC10
6RNA phosphodiester bond hydrolysis, exonucleolyticGO:0905038.8EXOSC9, EXOSC10
7immune responseGO:0069558.6CCR7, IL17A, EXOSC9
8gene expressionGO:0104678.5HARS, KARS, EXOSC9, GARS, IARS

Molecular functions related to Polymyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:0055249.0GARS, IARS, CHKB, KARS, HARS
2exoribonuclease activityGO:0045328.8EXOSC9, EXOSC10

Products for genes affiliated with Polymyositis

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  • Antibodies
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  • Lysates

Sources for Polymyositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet