PM
MCID: PLY041
MIFTS: 61

Polymyositis (PM) malady

Neuronal, Nephrological, Bone categories

Summaries for Polymyositis

Sources:
43NIH Rare Diseases, 44NINDS, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.  polymyositis affects skeletal muscles (those involved with making movement) on both sides of the body.  it is rarely seen in persons under age 18; most cases are seen in adults between the ages of 31 and 60. the cause of polymyositis is not fully understood. although there's no cure for polymyositis, treatment can improve muscle strength and function. last updated: 4/22/2009

MalaCards: Polymyositis, also known as adult-onset polymyositis, is related to arthritis and hepatitis c, and has symptoms including cough, hypotonia and muscle weakness/flaccidity. An important gene associated with Polymyositis is HARS (histidyl-tRNA synthetase), and among its related pathways are Generic Transcription Pathway and tRNA Aminoacylation. The compounds calcium and cysteine have been mentioned in the context of this disorder. Affiliated tissues include heart, skeletal muscle and small intestine, and related mouse phenotype hematopoietic system.

NINDS:44 Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.

Wikipedia:64 Polymyositis (PM)(\"inflammation of many muscles\") is a type of chronic inflammation of the muscles... more...

Aliases & Classifications for Polymyositis

Sources:
43NIH Rare Diseases, 44NINDS, 45Novoseek, 49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Nephrological, Bone


Characteristics (Orphanet epidemiological data):

49
polymyositis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

polymyositis 43 44 45 49 61
adult-onset polymyositis 49
pm 49


External Ids:

MESH via Orphanet36 D017285
ICD10 via Orphanet26 M33.2
SNOMED-CT via Orphanet58 31384009
UMLS via Orphanet62 C0085655
ICD1025 M33.2

Related Diseases for Polymyositis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Polymyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.6CCR7, MB, CD59, IL15, IL17A
2hepatitis c30.4RNPC3, IL15
3systemic lupus erythematosus30.3CCR7, CD40, CD59, RNPC3, IL15, IL17A
4bronchiolitis obliterans30.1IL17A
5adenocarcinoma30.1SFTPD, CHKA, CD59
6tuberculosis29.9IL17A, SFTPD, CCR7
7sjogren's syndrome29.9GZMA, CD40, RNPC3
8hepatitis b29.9RNPC3
9tropical spastic paraparesis29.9IL15, CNTN2
10osteoarthritis29.9IL17A, IL15, CD59, GZMA
11acute myocardial infarction29.7MB, PIK3C2A, CHKA, CHKB, CD40
12nephritis29.7IL17A, RNPC3
13duchenne muscular dystrophy29.7MB, PIK3C2A, CHKB
14autoimmune thyroiditis29.7CHKB, CD40, CD59
15inclusion body myositis10.5
16adult dermatomyositis10.4
17hepatitis a10.3
18premenstrual tension10.3
19mixed connective tissue disease10.2
20n syndrome10.2
21thymoma10.2
22autoimmune hepatitis10.2
23vasculitis10.2
24conn's syndrome10.1
25systemic scleroderma10.1
26char syndrome10.1
27amyopathic dermatomyositis10.1
28graft versus host disease10.1
29bronchiolitis obliterans organizing pneumonia10.1
30antiphospholipid syndrome10.1
31bronchiolitis10.1
32primary biliary cirrhosis10.1
33polyarteritis nodosa10.1
34pemphigus10.1
35childhood type dermatomyositis10.1
36t-cell leukemia10.1
37thymic carcinoma10.1
38giant cell myocarditis10.1
39dermatomyositis10.0CHKB, CHKA, PIK3C2A, GARS, MB, SFTPD
40rheumatoid arthritis10.0CCR7, SFTPD, GZMA, MB, CHKB, CNTN2
41myositis10.0GZMA, TARS, RNPC3, CHKB, CHKA, PIK3C2A
42ipex syndrome10.0CCR7, SFTPD, KARS, CNTN2, CD40, CD59
43burkitt's lymphoma10.0CCR7, GZMA, CHKA, CNTN2, CD40, CD59
44myopathy10.0MB, GARS, PIK3C2A, CHKA, CHKB, CD59
45leukemia10.0CCR7, GZMA, CNTN2, CD40, CD59, IL15
46pneumonia10.0SFTPD, MB, PIK3C2A, CD40, IL17A
47neuroleptic malignant syndrome10.0MB, PIK3C2A, CHKA, CHKB
48hypersensitivity reaction type ii disease10.0CCR7, CD40, CD59, RNPC3, IL15, IL17A
49viral infectious disease10.0GZMA, MB, CNTN2, RNPC3, IL15, IL17A
50ischemia10.0MB, PIK3C2A, CHKA, CHKB, CD40, CD59

Graphical network of the top 20 diseases related to Polymyositis:



Diseases related to polymyositis

Clinical Features for Polymyositis

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 40)
  • cough
  • hypotonia
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • abnormal emg/electromyogram/electropmyography
  • articular/joint pain/arthralgia
  • autoimmunity/autoimmune reaction/autoantibodies
  • constipation
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • anorexia
  • arthritis/synovitis/synovial proliferation
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness
  • gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal perforation
  • hepatomegaly/liver enlargement (excluding storage disease)
  • lung fibrosis
  • abnormal cry/voice/phonation disorder/nasal speech
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • cardiomyopathy/hypertrophic/dilated
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cardiac rhythm disorder/arrhythmia
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • angor pectoris/myocardial infarction
  • heart/cardiac failure
  • venous thrombosis/phlebitis/thrombophlebitis
  • vascularitis/vasculitides/arteritis
  • renal tubular defect/tubulopathy
  • abnormal gait
  • areflexia/hyporeflexia
  • elocution disorders/dysarthria/dysphonia
  • periarticular tissue anomaly/extraarticular calcifications
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • breast neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)

Drugs & Therapeutics for Polymyositis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Polymyositis

Drug clinical trials:

Search ClinicalTrials for Polymyositis

Search NIH Clinical Center for Polymyositis

Search CenterWatch for Polymyositis

Genetic Tests for Polymyositis

Anatomical Context for Polymyositis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Polymyositis:

33
Heart, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Adrenal gland, Breast, Skin, Placenta, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Tongue, Pituitary

Animal Models for Polymyositis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Polymyositis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.7IL17A, IL15, CD59, CD40, PIK3C2A, MB

Publications for Polymyositis

Sources:
51PubMed
See all sources

Articles related to Polymyositis:

(show top 50)    (show all 643)
idTitleAuthorsYear
1
Unusual case of metachronous EBV-associated B-cell and NK/T-cell lymphoma mimicking polymyositis-diagnostic challenges and pitfalls. (23963857)
2013
2
Camptocormia as a clinical manifestation of polymyositis/systemic sclerosis overlap myositis associated with anti-Ku. (22453528)
2013
3
The Evolving Spectrum of Polymyositis and Dermatomyositis-Moving Towards Clinicoserological Syndromes: A Critical Review. (24048686)
2013
4
Sugammadex in a patient with Sjogren's syndrome and polymyositis. (24233320)
2013
5
Comparative utility of LC3, p62 and TDP-43 immunohistochemistry in differentiation of inclusion body myositis from polymyositis and related inflammatory myopathies. (24252466)
2013
6
Left ventricular diastolic dysfunction -- early cardiac impairment in patients with polymyositis/dermatomyositis: a tissue Doppler imaging study. (23908445)
2013
7
Polymyositis. (22422831)
2012
8
Polymyositis and dermatomyositis in Sarawak: a profile of patients treated in the Sarawak General Hospital. (21243497)
2012
9
Intravenous immunoglobulin therapy in adult patients with polymyositis/dermatomyositis: a systematic literature review. (22274797)
2012
10
Interstitial lung disease outcomes by high-resolution computed tomography (HRCT) in Anti-Jo1 antibody-positive polymyositis patients: a single centre study and review of the literature. (21985773)
2012
11
Cardiac involvement in adult polymyositis or dermatomyositis: a systematic review. (22847365)
2012
12
Pilot study of interleukin-27 in pathogenesis of dermatomyositis and polymyositis: associated with interstitial lung diseases. (22863719)
2012
13
Prevalence of clinical and laboratory manifestations and comorbidities in polymyositis according to gender. (21952995)
2011
14
Incidence, cancer risk and mortality of dermatomyositis and polymyositis in Taiwan: a nationwide population study. (21895620)
2011
15
Patients with polymyositis or dermatomyositis have reduced grip force and health-related quality of life in comparison with reference values: an observational study. (21097879)
2011
16
Patient preference assessment reveals disease aspects not covered by recommended outcomes in polymyositis and dermatomyositis. (22389795)
2011
17
Trends in dermatomyositis- and polymyositis-related mortality in the state of SALo Paulo, Brazil, 1985-2007: multiple cause-of-death analysis. (20937106)
2010
18
Long-term outcome of patients with polymyositis/ dermatomyositis and anti-PM-Scl antibody. (19845665)
2010
19
Pericardial tamponade as the initial presentation in a patient with polymyositis. (20808173)
2010
20
Development of classic dermatomyositis rash years after diagnosis of juvenile polymyositis. (19734743)
2009
21
Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A. (19644888)
2009
22
Anesthetic management for cesarean delivery in a pregnant woman with polymyositis: A case report and review of literature. (20062684)
2009
23
Pneumomediastinum in interstitial lung disease associated with dermatomyositis and polymyositis. (19116970)
2009
24
Successful therapy with intravenous immunoglobulin in the management of polymyositis. (19040148)
2008
25
Disease-specific quality indicators, outcome measures and guidelines in polymyositis and dermatomyositis. (18021522)
2007
26
Characterization of pathogenic T cells and autoantibodies in C-protein-induced autoimmune polymyositis. (17900708)
2007
27
Muscle metabolism in patients with polymyositis simultaneously evaluated by using 31P-magnetic resonance spectroscopy and near-infrared spectroscopy. (16889559)
2007
28
Long-standing refractory polymyositis responding to mycophenolate mofetil: a case report and review of the literature. (17225929)
2007
29
Generalized intramuscular granulocytic sarcoma mimicking polymyositis. (17492441)
2007
30
Clinical images: polymyositis and vasculitis. (17907172)
2007
31
Step-up versus primary intensive approach to the treatment of interstitial pneumonia associated with dermatomyositis/polymyositis: a retrospective study. (17437167)
2007
32
Fatal polymyositis associated with sarcoidosis. (17673401)
2007
33
Two distinct clinical types of interstitial lung disease associated with polymyositis-dermatomyositis. (17428649)
2007
34
CD8-positive T cell-induced liver damage was found in a patient with polymyositis. (17043378)
2006
35
Steroid-responsive subacute polymyositis in an adult following respiratory syncytial virus infection. (16409434)
2006
36
Successful salvage therapy of intravenous cyclophosphamide for refractory polymyositis in an elderly patient: case report. (17166415)
2006
37
Polymyositis-dermatomyositis and infections. (16769652)
2006
38
Polymyositis/dermatomyositis and interstitial lung disease: a new therapeutic approach with T-cell-specific immunosuppressants. (16227154)
2005
39
Acute polymyositis after donor lymphocyte infusion. (15654909)
2005
40
Detection of the levels of neuropeptides, ACTH and cortisol in the blood of patients with polymyositis/dermatomyositis and their significance. (15187306)
2004
41
Association of the proinflammatory haplotype (MICA5.1/TNF2/TNFa2/DRB1*03) with polymyositis and dermatomyositis. (15022353)
2004
42
Late-onset polymyositis in a case of poikilodermatomyositis. (15260401)
2003
43
Polymyositis--a further investigation. (14658779)
2003
44
The role of lymphotoxin in pathogenesis of polymyositis. (11045674)
2000
45
Decreased expression of interleukin-1alpha, interleukin-1beta, and cell adhesion molecules in muscle tissue following corticosteroid treatment in patients with polymyositis and dermatomyositis. (10693873)
2000
46
Increased CD40 expression on muscle cells of polymyositis and dermatomyositis: role of CD40-CD40 ligand interaction in IL-6, IL-8, IL-15, and monocyte chemoattractant protein-1 production. (10843719)
2000
47
MHC class I-mediated cytotoxicity does not induce apoptosis in muscle fibers nor in inflammatory T cells: studies in patients with polymyositis, dermatomyositis, and inclusion body myositis. (8957443)
1996
48
Pulmonary capillaritis and diffuse alveolar hemorrhage. A primary manifestation of polymyositis. (7767555)
1995
49
Degradative activity of granzyme A on skeletal muscle proteins in vitro: a possible molecular mechanism for muscle fiber damage in polymyositis. (8268727)
1993
50
A case of mixed connective tissue disease developed into overlap syndrome of progressive systemic sclerosis, systemic lupus erythematosus, polymyositis and SjAPgren's syndrome]. (2222196)
1990

Genetic Variations for Polymyositis

Expression for genes affiliated with Polymyositis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Polymyositis

Search GEO for disease gene expression data for Polymyositis.

Pathways for genes affiliated with Polymyositis

Sources:
54Reactome, 30KEGG
See all sources

Pathways related to Polymyositis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6KARS, HARS, GARS, IARS, TARS, EXOSC9
2
Hide members
10.6TARS, IARS, GARS, HARS, KARS

Compounds for genes affiliated with Polymyositis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Polymyositis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2414.2CCR7, CHKA, GARS, CNTN2, CD40, CD59
2cysteine4511.1CNTN2, CHKB, GARS, CHKA, IL15, CD40
3tyrosine4511.1CNTN2, CCR7, CHKA, IL17A, IL15, RNPC3
4alanine4511.1CHKA, GARS, PIK3C2A, IL15, CNTN2, CHKB
5cyclosporin a45 29 6013.1CNTN2, IL15, RNPC3, CD59, CD40, GZMA
6steroid4511.1SFTPD, IL17A, PIK3C2A, IL15, CD40, CNTN2
7oxygen45 2412.1SFTPD, CD59, CD40, PIK3C2A, MB, CNTN2
8glutamate4511.1CNTN2, MB, CD40, CHKB, CHKA, KARS
9phosphatidylinositol4511.1CD59, CD40, CCR7, SFTPD, PIK3C2A, CHKA
10thymidine45 2412.1IL15, IL17A, CD40, SFTPD, CHKA, CNTN2
11Adenosine triphosphate11 2412.1TARS, IARS, CHKB, KARS, HARS, GARS
12superoxide45 2412.0CD59, PIK3C2A, GZMA, IL15, CHKA, CD40
13creatinine4511.0MB, CD40, PIK3C2A, CHKA, CHKB, IL15
14trna4511.0RNPC3, KARS, TARS, GARS, IARS
15pyrophosphate45 2412.0TARS, KARS, HARS, GARS, PIK3C2A, IARS
16serine4511.0GARS, TARS, RNPC3, CHKA, KARS, MB
17atorvastatin45 50 29 11 2415.0CD59, CHKB, CHKA, CD40, PIK3C2A
18prednisolone45 29 1113.0SFTPD, CD40, PIK3C2A, MB, CHKB
19phosphocreatine45 2412.0MB, CHKB, CHKA, PIK3C2A
20alpha-hydroxybutyrate4511.0PIK3C2A, MB, CHKB
21ionomycin4511.0GZMA, IL15, IL17A, CD40, CNTN2
22tacrolimus45 50 1113.0IL15, CD40, IL17A, CCR7, CHKB
23vegf4511.0MB, CD40, CNTN2, CHKB, PIK3C2A, IL15
24lactate4511.0SFTPD, MB, CHKA, PIK3C2A, CHKB, CD59
25fluvastatin45 50 29 1113.9PIK3C2A, CD40, CHKB, MB
26methotrexate45 50 1112.9IL17A, CD40, IL15, CHKB, PIK3C2A
27zinc45 2411.9CD40, RNPC3, GARS, TARS, CNTN2, CHKB
28dantrolene45 29 1112.9PIK3C2A, MB, CHKB
29succinylcholine45 29 1112.9CHKB, MB, PIK3C2A
30leucine4510.9KARS, SFTPD, GARS, CHKB, CNTN2, RNPC3
31lipid4510.9CD40, IL17A, CD59, SFTPD, IL15, CHKA
32gamma-hydroxybutyrate4510.9CHKB, PIK3C2A, MB
33anticodon4510.9KARS, TARS, GARS
34rantes4510.9CCR7, IL17A, CD40, GZMA, IL15
35Adenosine monophosphate11 2411.9HARS, GARS, IARS, TARS, KARS
36pravastatin45 50 29 11 2414.9PIK3C2A, CHKA, CD40, CHKB
37phosphoric acid45 2411.9KARS, HARS, GARS, IARS, TARS
38pge24510.8MB
39adenylate4510.8CHKB, IL15, RNPC3, MB, CD40, CHKA
40atp45 2911.8RNPC3, GARS, PIK3C2A, IARS, CHKB, CHKA
41lovastatin45 50 60 29 1114.8CD40, CHKA, PIK3C2A, CHKB
42aminoacyl-trna4510.8IARS, KARS, GARS
43gemfibrozil45 29 1112.7CHKB, CHKA, PIK3C2A
44citrate4510.7CHKA, PIK3C2A, CHKB, MB
45cyclocreatine4510.7CHKB, CHKA
46cholesterol45 29 11 2413.6CHKA, CHKB, CD40, CD59, PIK3C2A, SFTPD
47glycogen45 2411.6PIK3C2A, CHKB, CHKA
48cerivastatin45 50 29 1113.5PIK3C2A, CHKB, CD40
49simvastatin45 50 60 29 11 2415.5CHKA, CD40, PIK3C2A, CHKB
50choline45 11 2412.3CNTN2, PIK3C2A, CHKA, CHKB

GO Terms for genes affiliated with Polymyositis

Sources:
16Gene Ontology
See all sources

Cellular components related to Polymyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1exosome (RNase complex)GO:00017810.5EXOSC9, EXOSC10
2nuclear exosome (RNase complex)GO:00017610.4EXOSC10, EXOSC9
3cytosolGO:00582910.4KARS, HARS, GARS, PIK3C2A, CHKA, CHKB

Biological processes related to Polymyositis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1tRNA aminoacylation for protein translationGO:00641810.8TARS, IARS, GARS, HARS, KARS
2gene expressionGO:01046710.7HARS, EXOSC9, KARS, TARS, IARS, GARS
3immune responseGO:00695510.7CCR7, EXOSC9, GZMA, IL15, IL17A
4nuclear polyadenylation-dependent rRNA catabolic processGO:07103510.7EXOSC9, EXOSC10
5diadenosine tetraphosphate biosynthetic processGO:01596610.7GARS, KARS
6nuclear mRNA surveillanceGO:07102810.6EXOSC9, EXOSC10
7phosphatidylethanolamine biosynthetic processGO:00664610.5CHKA, CHKB
8nuclear-transcribed mRNA catabolic processGO:00095610.5EXOSC9, EXOSC10
9CDP-choline pathwayGO:00665710.4CHKB, CHKA
10inflammatory responseGO:00695410.3IL17A, IL15, CD40, CCR7

Molecular functions related to Polymyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00552410.6HARS, GARS, PIK3C2A, CHKA, CHKB, IARS
2choline kinase activityGO:00410310.5CHKB, CHKA
3exoribonuclease activityGO:00453210.5EXOSC9, EXOSC10
4ethanolamine kinase activityGO:00430510.2CHKA, CHKB

Products for genes affiliated with Polymyositis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polymyositis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet