PM
MCID: PLY041
MIFTS: 58

Polymyositis (PM) malady

Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases categories
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Summaries for Polymyositis

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43NIH Rare Diseases, 44NINDS, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.  polymyositis affects skeletal muscles (those involved with making movement) on both sides of the body.  it is rarely seen in persons under age 18; most cases are seen in adults between the ages of 31 and 60. the cause of polymyositis is not fully understood. although there's no cure for polymyositis, treatment can improve muscle strength and function. last updated: 4/22/2009

MalaCards: Polymyositis, also known as PM, is related to dermatomyositis and myositis, and has symptoms including abnormal gait, areflexia/hyporeflexia and elocution disorders/dysarthria/dysphonia. An important gene associated with Polymyositis is HARS (histidyl-tRNA synthetase), and among its related pathways are Th17 Differentiation and tRNA Aminoacylation. The compounds anticodon and hydroxylysine have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and skeletal muscle.

NINDS:44 Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.

Wikipedia:65 Polymyositis (PM)(\"inflammation of many muscles\") is a type of chronic inflammation of the muscles... more...

Aliases & Classifications for Polymyositis

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43NIH Rare Diseases, 44NINDS, 45Novoseek, 49Orphanet, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

49
polymyositis:
Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

polymyositis 43 44 45 49 62
pm 49


External Ids:

MESH via Orphanet36 D017285
ICD10 via Orphanet26 M33.2
SNOMED-CT via Orphanet59 31384009
UMLS via Orphanet63 C0085655
ICD1025 M33.2

Related Diseases for Polymyositis

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17GeneCards, 18GeneDecks
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Diseases related to Polymyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1dermatomyositis31.3SFTPD, CHKB, CCR7, IL17A, GARS, CD59
2myositis31.1HARS, CHKB, GARS
3interstitial lung disease31.0SFTPD, HARS
4myopathy30.7CHKB, GARS, CD59
5arthritis30.5CD59, IL17A, CCR7
6rheumatoid arthritis30.3SFTPD, CHKB, CCR7, IL17A, CNTN2, CD59
7systemic lupus erythematosus30.2CCR7, IL17A, CD59
8leukemia30.0CCR7, IL17A, CNTN2, CD59
9tuberculosis29.9IL17A, CCR7, SFTPD
10bronchitis29.8CHKB, IL17A
11autoimmune thyroiditis29.7CD59, CHKB
12gastritis29.7CD59, IL17A, SFTPD
13inclusion body myositis10.5
14pneumonia10.4
15scleroderma10.4
16hepatitis10.4
17myocarditis10.3
18connective tissue disease10.3
19lupus erythematosus10.3
20mixed connective tissue disease10.2
21hypothyroidism10.2
22thymoma10.2
23autoimmune hepatitis10.2
24glomerulonephritis10.2
25muscular dystrophy10.2
26vasculitis10.2
27childhood type dermatomyositis10.1
28breast cancer10.1
29hypertension10.1
30myasthenia gravis10.1
31amyopathic dermatomyositis10.1
32graft versus host disease10.1
33bronchiolitis10.1
34bronchiolitis obliterans10.1
35bronchiolitis obliterans organizing pneumonia10.1
36pemphigus10.1
37polyarteritis nodosa10.1
38primary biliary cirrhosis10.1
39adult dermatomyositis10.1
40adenocarcinoma10.1
41fasciitis10.1
42hepatocellular carcinoma10.1
43intestinal pseudo-obstruction10.1
44pancreatitis10.1
45purpura10.1
46respiratory failure10.1
47thymic carcinoma10.1
48thyroiditis10.1
49antisynthetase syndrome10.1
50paraneoplastic syndromes10.1

Graphical network of the top 20 diseases related to Polymyositis:



Diseases related to polymyositis

Symptoms for Polymyositis

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49Orphanet
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Symptoms:

49 (show all 40)
  • abnormal gait
  • areflexia/hyporeflexia
  • elocution disorders/dysarthria/dysphonia
  • periarticular tissue anomaly/extraarticular calcifications
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • breast neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • autoimmunity/autoimmune reaction/autoantibodies
  • renal tubular defect/tubulopathy
  • vascularitis/vasculitides/arteritis
  • fever/chilling
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • arthritis/synovitis/synovial proliferation
  • anorexia
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • constipation
  • articular/joint pain/arthralgia
  • abnormal emg/electromyogram/electropmyography
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • myalgia/muscular pain
  • muscle weakness/flaccidity
  • hypotonia
  • asthenia/fatigue/weakness
  • gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
  • acute abdominal pain/colic
  • venous thrombosis/phlebitis/thrombophlebitis
  • heart/cardiac failure
  • angor pectoris/myocardial infarction
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • cardiac rhythm disorder/arrhythmia
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cardiomyopathy/hypertrophic/dilated
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • abnormal cry/voice/phonation disorder/nasal speech
  • lung fibrosis
  • hepatomegaly/liver enlargement (excluding storage disease)
  • intestinal perforation
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • cough

Drugs & Therapeutics for Polymyositis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Polymyositis

Search NIH Clinical Center for Polymyositis

Genetic Tests for Polymyositis

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Anatomical Context for Polymyositis

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33MalaCards
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MalaCards organs/tissues related to Polymyositis:

33
Lung, T cells, Skeletal muscle, Heart, Breast, Liver, Bone, Ovary, Monocytes, Testes, Endothelial, Skin, Thyroid, Colon, Myeloid, B cells, Kidney, Small intestine, Pituitary, Adrenal gland, Placenta, Pancreas, Tongue

Animal Models for Polymyositis or affiliated genes

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Publications for Polymyositis

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52PubMed
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Articles related to Polymyositis:

(show top 50)    (show all 639)
idTitleAuthorsYear
1
Cutaneous tuberculous gummas in a patient with polymyositis. (23539011)
2013
2
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? (23358869)
2013
3
Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: a randomized, placebo-phase trial. (23124935)
2013
4
A case of polymyositis associated with Hashimoto's thyroiditis. (23682237)
2013
5
The high prevalence of metabolic syndrome in polymyositis. (24144101)
2013
6
Marked increase in serum KL-6 and surfactant proteinA D levels during the first 4A weeks after treatment predicts poor prognosis in patients with active interstitial pneumonia associated with polymyositis/dermatomyositis. (22983659)
2013
7
Age at onset and gender distribution of systemic lupus erythematosus, polymyositis/dermatomyositis, and systemic sclerosis in Japan. (22903259)
2013
8
Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine. (22284862)
2012
9
Polymyositis. (22422831)
2012
10
Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis. (21881594)
2012
11
Prevalence of clinical and laboratory manifestations and comorbidities in polymyositis according to gender. (21952995)
2011
12
Abatacept for treatment of refractory polymyositis. (21550833)
2011
13
IV immunoglobulin might be considered as a first-line treatment of severe interstitial lung disease associated with polymyositis. (21813543)
2011
14
Nerve conduction studies in patients with dermatomyositis or polymyositis. (20367974)
2010
15
Increased serum concentration of immune cell derived microparticles in polymyositis/dermatomyositis. (20043950)
2010
16
Transverse myelitis and polymyositis associated with antiphospholipid antibody syndrome. (20493629)
2010
17
Lymphoma-associated polymyositis in dogs. (19780930)
2009
18
Malignancies associated with dermatomyositis and polymyositis in Taiwan: a nationwide population-based study. (19558555)
2009
19
Thoracic epidural anesthesia for a polymyositis patient undergoing awake mini-thoracotomy and unroofing of a huge pulmonary bulla. (18390401)
2008
20
Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis. (18821695)
2008
21
Intestinal pseudo-obstruction associated with polymyositis successfully treated with somatostatin analog]. (18323156)
2008
22
Autoantibody to signal recognition particle in African American girls with juvenile polymyositis. (18322984)
2008
23
Recurrent placental massive perivillous fibrin deposition associated with polymyositis: a case report and review of the literature. (17990939)
2008
24
Flow cytometric analysis of lymphocyte subpopulations and TH1/TH2 balance in patients with polymyositis and dermatomyositis. (18797118)
2008
25
Polymyositis and pemphigus vulgaris in a patient: successful treatment with rituximab. (18455465)
2008
26
Disease-specific quality indicators, outcome measures and guidelines in polymyositis and dermatomyositis. (18021522)
2007
27
A rare case of systemic autoimmune disease with intricate features of systemic sclerosis, lupus, polymyositis and rheumatoid arthritis. Overlap syndrome or mixed connective tissue disease? (17932479)
2007
28
Prognosis of polymyositis and dermatomyositis. (16642405)
2007
29
Malignant thymoma associated with fatal myocarditis and polymyositis in a 32-year-old woman with a history of hairy cell leukemia. (16601447)
2006
30
CD8-positive T cell-induced liver damage was found in a patient with polymyositis. (17043378)
2006
31
Pseudoxanthoma elasticum and polymyositis in a child. (16428004)
2006
32
Steroid-responsive subacute polymyositis in an adult following respiratory syncytial virus infection. (16409434)
2006
33
A case of polymyositis with concomitant diffuse alveolar damage following interstitial pneumonia]. (17233391)
2006
34
Long-term persistence of clonally expanded T cells in patients with polymyositis. (15514965)
2004
35
Polymyositis: an ongoing discussion about a disease entity. (14732633)
2004
36
Polymyositis associated with HIV infection during immune restoration induced by highly active anti-retroviral therapy. (15485025)
2004
37
Polymyositis induced or associated with lipid-lowering drugs: five cases]. (15050796)
2004
38
PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome. (14872500)
2004
39
Immunolocalization of protectin (CD59) and macrophages in polymyositis and dermatomyositis. (15020079)
2004
40
Efficacy of tacrolimus in treatment of polymyositis associated with myasthenia gravis. (15168159)
2004
41
Critical requirement for professional APCs in eliciting T cell responses to novel fragments of histidyl-tRNA synthetase (Jo-1) in Jo-1 antibody-positive polymyositis. (12471150)
2002
42
Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. (10638867)
2000
43
Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis. (11055823)
2000
44
Benefit of 6 months long-term physical training in polymyositis/dermatomyositis patients. (9973161)
1998
45
CD8 and CD4 T cell-mediated polymyositis complicating the HTLV-1 associated myelopathy. Quantitative evaluation of corticosteroid treatment. (8891056)
1996
46
Onset of polymyositis with autoantibodies to threonyl-tRNA synthetase during pregnancy. (7983666)
1994
47
Relationship of cancer to inflammatory muscle diseases. Dermatomyositis, polymyositis, and inclusion body myositis. (7855330)
1994
48
Degradative activity of granzyme A on skeletal muscle proteins in vitro: a possible molecular mechanism for muscle fiber damage in polymyositis. (8268727)
1993
49
Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome. (2308937)
1990
50
Polymyositis in eosinophilic fasciitis. Review and case report. (7389757)
1980

Variations for Polymyositis

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Expression for genes affiliated with Polymyositis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polymyositis

Search GEO for disease gene expression data for Polymyositis.

Pathways for genes affiliated with Polymyositis

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50PathCards, 54R&D Systems, 55Reactome, 30KEGG
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Pathways related to Polymyositis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4IL17A, CCR7
2
Show member pathways
9.3GARS, IARS, KARS, HARS
3
Show member pathways
8.5HARS, KARS, IARS, EXOSC9, GARS

Compounds for genes affiliated with Polymyositis

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45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Polymyositis according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1anticodon4510.2KARS, GARS
2hydroxylysine4510.1CHKB, SFTPD
3aminoacyl-trna4510.0GARS, IARS, KARS
4trna459.9GARS, IARS, KARS
5fitc459.7CCR7, CD59
6mannan459.7SFTPD, IL17A
7Adenosine monophosphate24 1110.7HARS, KARS, IARS, GARS
8phosphoric acid45 2410.7GARS, IARS, KARS, HARS
9pyrophosphate45 2410.7GARS, IARS, KARS, HARS
10nickel45 2410.6IL17A, CCR7
11latex459.6CHKB, CCR7, CNTN2
12ccl445 2910.4IL17A, CCR7
13endotoxin459.4IL17A, CHKB, SFTPD
14tacrolimus45 51 1111.4CHKB, CCR7, IL17A
15Adenosine triphosphate24 1110.3HARS, KARS, CHKB, IARS, GARS
16phospholipid459.2SFTPD, CHKB, CD59
17glutamate459.2KARS, CHKB, CNTN2, GARS
18leucine459.1SFTPD, KARS, CHKB, CNTN2, GARS
19alanine459.0KARS, CHKB, CCR7, CNTN2, GARS
20cysteine459.0SFTPD, KARS, CHKB, CNTN2, GARS
21thymidine45 2410.0CNTN2, IL17A, CHKB, SFTPD
22steroid458.9CNTN2, IL17A, CHKB, SFTPD
23cyclosporin a45 29 6110.8CD59, CNTN2, IL17A, CHKB
24phosphatidylinositol458.8CD59, IL17A, CCR7, SFTPD
25atp45 299.7CHKB, IARS, GARS, CD59
26oxygen45 249.7CD59, CNTN2, CHKB, SFTPD
27tyrosine458.2CD59, GARS, CNTN2, IL17A, CCR7
28calcium45 51 24 1111.1SFTPD, KARS, CHKB, CCR7, CNTN2, GARS

GO Terms for genes affiliated with Polymyositis

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16Gene Ontology
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Cellular components related to Polymyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear exosome (RNase complex)GO:0001769.0EXOSC9, EXOSC10
2exosome (RNase complex)GO:0001788.8EXOSC9, EXOSC10
3cytosolGO:0058298.1KARS, CHKB, IARS, EXOSC9, GARS, HARS

Biological processes related to Polymyositis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1diadenosine tetraphosphate biosynthetic processGO:01596610.0KARS, GARS
2tRNA aminoacylation for protein translationGO:0064189.5GARS, IARS, KARS, HARS
3nuclear polyadenylation-dependent rRNA catabolic processGO:0710359.3EXOSC10, EXOSC9
4nuclear mRNA surveillanceGO:0710289.1EXOSC9, EXOSC10
5nuclear-transcribed mRNA catabolic processGO:0009569.0EXOSC10, EXOSC9
6RNA phosphodiester bond hydrolysis, exonucleolyticGO:0905038.8EXOSC9, EXOSC10
7immune responseGO:0069558.6EXOSC9, IL17A, CCR7
8gene expressionGO:0104678.5HARS, KARS, IARS, EXOSC9, GARS

Molecular functions related to Polymyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:0055249.0GARS, IARS, CHKB, KARS, HARS
2exoribonuclease activityGO:0045328.8EXOSC9, EXOSC10

Products for genes affiliated with Polymyositis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polymyositis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet