MCID: PLY041
MIFTS: 51

Polymyositis malady

Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases categories

Aliases & Classifications for Polymyositis

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Sources:
41NIH Rare Diseases, 42NINDS, 43Novoseek, 47Orphanet, 60UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Polymyositis, Aliases & Descriptions:

Name: Polymyositis 41 42 43 47 60
 
Pm 47


Classifications:



Characteristics (Orphanet epidemiological data):

47
polymyositis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe),1-9/1000000 (Argentina),1-9/100000 (Argentina),1-9/1000000 (Australia),1-9/100000 (Australia),1-9/1000000 (Spain),1-9/1000000 (Sweden); Age of onset: Adult,Elderly; Age of death: adult


External Ids:

Orphanet47 732
MESH via Orphanet34 D017285
ICD10 via Orphanet26 M33.2
UMLS via Orphanet61 C0085655
ICD1025 M33.2

Summaries for Polymyositis

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NIH Rare Diseases:41 Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.  polymyositis affects skeletal muscles (those involved with making movement) on both sides of the body.  it is rarely seen in persons under age 18; most cases are seen in adults between the ages of 31 and 60. the cause of polymyositis is not fully understood. although there's no cure for polymyositis, treatment can improve muscle strength and function. last updated: 4/22/2009

MalaCards based summary: Polymyositis, also known as pm, is related to interstitial lung disease and myositis, and has symptoms including muscular hypotonia, muscle weakness and arthralgia. An important gene associated with Polymyositis is HARS (histidyl-tRNA synthetase), and among its related pathways are Th17 Differentiation and tRNA Aminoacylation. The compounds anticodon and hydroxylysine have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and heart.

NINDS:42 Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.

Wikipedia:63 Polymyositis (PM)(\"inflammation of many muscles\") is a type of chronic inflammation of the muscles... more...

Related Diseases for Polymyositis

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Diseases related to Polymyositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 197)
idRelated DiseaseScoreTop Affiliating Genes
1interstitial lung disease31.3SFTPD, HARS
2myositis31.3HARS, CHKB, GARS
3myopathy30.6CHKB, GARS, CD59
4dermatomyositis30.5SFTPD, CHKB, CCR7, IL17A, GARS, CD59
5arthritis30.1CD59, IL17A, CCR7
6systemic lupus erythematosus30.0CCR7, IL17A, CD59
7tuberculosis29.9IL17A, CCR7, SFTPD
8gastritis29.5CD59, IL17A, SFTPD
9rheumatoid arthritis29.3SFTPD, CHKB, CCR7, IL17A, CNTN2, CD59
10leukemia29.2CCR7, IL17A, CNTN2, CD59
11inclusion body myositis10.6
12pneumonia10.4
13scleroderma10.4
14hepatitis10.4
15connective tissue disease10.3
16lupus erythematosus10.3
17myocarditis10.3
18thymoma10.3
19mixed connective tissue disease10.2
20hypothyroidism10.2
21autoimmune hepatitis10.2
22glomerulonephritis10.2
23myasthenia gravis10.2
24muscular dystrophy10.2
25breast cancer10.1
26childhood type dermatomyositis10.1
27adult dermatomyositis10.1
28vasculitis10.1
29hepatocellular carcinoma10.1
30bronchiolitis obliterans10.1
31primary biliary cirrhosis10.1
32bronchiolitis10.1
33bronchiolitis obliterans organizing pneumonia10.1
34pemphigus10.1
35polyarteritis nodosa10.1
36adenocarcinoma10.1
37fasciitis10.1
38intestinal pseudo-obstruction10.1
39pancreatitis10.1
40purpura10.1
41respiratory failure10.1
42thymic carcinoma10.1
43thyroiditis10.1
44amyopathic dermatomyositis10.1
45antisynthetase syndrome10.1
46chronic graft versus host disease10.1
47paraneoplastic syndromes10.1
48endotheliitis10.1
49non-suppurative otitis media10.1CHKB, IL17A
50pick disease10.0CD59, CHKB

Graphical network of the top 20 diseases related to Polymyositis:



Diseases related to polymyositis

Symptoms for Polymyositis

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Symptoms:

 47 (show all 40)
  • cough
  • hypotonia
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • abnormal emg/electromyogram/electropmyography
  • articular/joint pain/arthralgia
  • autoimmunity/autoimmune reaction/autoantibodies
  • constipation
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • anorexia
  • arthritis/synovitis/synovial proliferation
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness
  • gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal perforation
  • hepatomegaly/liver enlargement (excluding storage disease)
  • lung fibrosis
  • abnormal cry/voice/phonation disorder/nasal speech
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • cardiomyopathy/hypertrophic/dilated
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cardiac rhythm disorder/arrhythmia
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • angor pectoris/myocardial infarction
  • heart/cardiac failure
  • venous thrombosis/phlebitis/thrombophlebitis
  • vascularitis/vasculitides/arteritis
  • renal tubular defect/tubulopathy
  • abnormal gait
  • areflexia/hyporeflexia
  • elocution disorders/dysarthria/dysphonia
  • periarticular tissue anomaly/extraarticular calcifications
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • breast neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)

HPO human phenotypes related to Polymyositis:

(show all 34)
id Description Frequency HPO Source Accession
1 muscular hypotonia hallmark (90%) HP:0001252
2 muscle weakness hallmark (90%) HP:0001324
3 arthralgia hallmark (90%) HP:0002829
4 autoimmunity hallmark (90%) HP:0002960
5 myalgia hallmark (90%) HP:0003326
6 emg abnormality hallmark (90%) HP:0003457
7 arthritis typical (50%) HP:0001369
8 weight loss typical (50%) HP:0001824
9 constipation typical (50%) HP:0002019
10 anorexia typical (50%) HP:0002039
11 restrictive lung disease typical (50%) HP:0002091
12 respiratory insufficiency typical (50%) HP:0002093
13 abnormality of temperature regulation typical (50%) HP:0004370
14 abnormality of the renal tubule occasional (7.5%) HP:0000091
15 chondrocalcinosis occasional (7.5%) HP:0000934
16 gait disturbance occasional (7.5%) HP:0001288
17 reduced tendon reflexes occasional (7.5%) HP:0001315
18 abnormality of the voice occasional (7.5%) HP:0001608
19 abnormality of the mitral valve occasional (7.5%) HP:0001633
20 congestive heart failure occasional (7.5%) HP:0001635
21 hypertrophic cardiomyopathy occasional (7.5%) HP:0001639
22 coronary artery disease occasional (7.5%) HP:0001677
23 abnormality of the pericardium occasional (7.5%) HP:0001697
24 abdominal pain occasional (7.5%) HP:0002027
25 neurological speech impairment occasional (7.5%) HP:0002167
26 pulmonary fibrosis occasional (7.5%) HP:0002206
27 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
28 hepatomegaly occasional (7.5%) HP:0002240
29 vasculitis occasional (7.5%) HP:0002633
30 thrombophlebitis occasional (7.5%) HP:0004418
31 arrhythmia occasional (7.5%) HP:0011675
32 neoplasm of the breast occasional (7.5%) HP:0100013
33 neoplasm of the lung occasional (7.5%) HP:0100526
34 ovarian neoplasm occasional (7.5%) HP:0100615

Drugs & Therapeutics for Polymyositis

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Drug clinical trials:

Search ClinicalTrials for Polymyositis

Search NIH Clinical Center for Polymyositis

Genetic Tests for Polymyositis

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Anatomical Context for Polymyositis

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MalaCards organs/tissues related to Polymyositis:

31
Lung, T cells, Heart, Skeletal muscle, Breast, Liver, Bone, Ovary, Testes, Monocytes, Thyroid, Skin, Endothelial, Colon, Myeloid, B cells, Tongue, Small intestine, Kidney, Pancreas, Adrenal gland, Placenta, Pituitary, Neutrophil

Animal Models for Polymyositis or affiliated genes

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Publications for Polymyositis

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Articles related to Polymyositis:

(show top 50)    (show all 673)
idTitleAuthorsYear
1
High-dose subcutaneous immunoglobulins for the treatment of severe treatment-resistant polymyositis. (25140268)
2014
2
Increased subsequent risk of acute coronary syndrome for patients with dermatomyositis/polymyositis: a nationwide population-based retrospective cohort study. (25205256)
2014
3
Cutaneous tuberculous gummas in a patient with polymyositis. (23539011)
2013
4
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? (23358869)
2013
5
Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: a randomized, placebo-phase trial. (23124935)
2013
6
A case of polymyositis associated with Hashimoto's thyroiditis. (23682237)
2013
7
The high prevalence of metabolic syndrome in polymyositis. (24144101)
2013
8
Marked increase in serum KL-6 and surfactant proteinA D levels during the first 4A weeks after treatment predicts poor prognosis in patients with active interstitial pneumonia associated with polymyositis/dermatomyositis. (22983659)
2013
9
Age at onset and gender distribution of systemic lupus erythematosus, polymyositis/dermatomyositis, and systemic sclerosis in Japan. (22903259)
2013
10
Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine. (22284862)
2012
11
Polymyositis. (22422831)
2012
12
Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis. (21881594)
2012
13
Prevalence of clinical and laboratory manifestations and comorbidities in polymyositis according to gender. (21952995)
2011
14
Abatacept for treatment of refractory polymyositis. (21550833)
2011
15
IV immunoglobulin might be considered as a first-line treatment of severe interstitial lung disease associated with polymyositis. (21813543)
2011
16
Nerve conduction studies in patients with dermatomyositis or polymyositis. (20367974)
2010
17
Increased serum concentration of immune cell derived microparticles in polymyositis/dermatomyositis. (20043950)
2010
18
Lymphoma-associated polymyositis in dogs. (19780930)
2009
19
Malignancies associated with dermatomyositis and polymyositis in Taiwan: a nationwide population-based study. (19558555)
2009
20
Thoracic epidural anesthesia for a polymyositis patient undergoing awake mini-thoracotomy and unroofing of a huge pulmonary bulla. (18390401)
2008
21
Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis. (18821695)
2008
22
Intestinal pseudo-obstruction associated with polymyositis successfully treated with somatostatin analog]. (18323156)
2008
23
Autoantibody to signal recognition particle in African American girls with juvenile polymyositis. (18322984)
2008
24
Recurrent placental massive perivillous fibrin deposition associated with polymyositis: a case report and review of the literature. (17990939)
2008
25
Flow cytometric analysis of lymphocyte subpopulations and TH1/TH2 balance in patients with polymyositis and dermatomyositis. (18797118)
2008
26
Polymyositis and pemphigus vulgaris in a patient: successful treatment with rituximab. (18455465)
2008
27
Disease-specific quality indicators, outcome measures and guidelines in polymyositis and dermatomyositis. (18021522)
2007
28
A rare case of systemic autoimmune disease with intricate features of systemic sclerosis, lupus, polymyositis and rheumatoid arthritis. Overlap syndrome or mixed connective tissue disease? (17932479)
2007
29
Malignant thymoma associated with fatal myocarditis and polymyositis in a 32-year-old woman with a history of hairy cell leukemia. (16601447)
2006
30
CD8-positive T cell-induced liver damage was found in a patient with polymyositis. (17043378)
2006
31
Pseudoxanthoma elasticum and polymyositis in a child. (16428004)
2006
32
Steroid-responsive subacute polymyositis in an adult following respiratory syncytial virus infection. (16409434)
2006
33
A case of polymyositis with concomitant diffuse alveolar damage following interstitial pneumonia]. (17233391)
2006
34
Long-term persistence of clonally expanded T cells in patients with polymyositis. (15514965)
2004
35
Polymyositis: an ongoing discussion about a disease entity. (14732633)
2004
36
Polymyositis associated with HIV infection during immune restoration induced by highly active anti-retroviral therapy. (15485025)
2004
37
Polymyositis induced or associated with lipid-lowering drugs: five cases]. (15050796)
2004
38
PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome. (14872500)
2004
39
Immunolocalization of protectin (CD59) and macrophages in polymyositis and dermatomyositis. (15020079)
2004
40
Efficacy of tacrolimus in treatment of polymyositis associated with myasthenia gravis. (15168159)
2004
41
Critical requirement for professional APCs in eliciting T cell responses to novel fragments of histidyl-tRNA synthetase (Jo-1) in Jo-1 antibody-positive polymyositis. (12471150)
2002
42
Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. (10638867)
2000
43
Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis. (11055823)
2000
44
Benefit of 6 months long-term physical training in polymyositis/dermatomyositis patients. (9973161)
1998
45
CD8 and CD4 T cell-mediated polymyositis complicating the HTLV-1 associated myelopathy. Quantitative evaluation of corticosteroid treatment. (8891056)
1996
46
Onset of polymyositis with autoantibodies to threonyl-tRNA synthetase during pregnancy. (7983666)
1994
47
Relationship of cancer to inflammatory muscle diseases. Dermatomyositis, polymyositis, and inclusion body myositis. (7855330)
1994
48
Degradative activity of granzyme A on skeletal muscle proteins in vitro: a possible molecular mechanism for muscle fiber damage in polymyositis. (8268727)
1993
49
Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome. (2308937)
1990
50
Polymyositis in eosinophilic fasciitis. Review and case report. (7389757)
1980

Variations for Polymyositis

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Expression for genes affiliated with Polymyositis

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Search GEO for disease gene expression data for Polymyositis.

Pathways for genes affiliated with Polymyositis

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Pathways related to Polymyositis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4IL17A, CCR7
2
Show member pathways
9.3GARS, IARS, KARS, HARS
3
Show member pathways
8.5HARS, KARS, IARS, EXOSC9, GARS

Compounds for genes affiliated with Polymyositis

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Compounds related to Polymyositis according to GeneCards Suite gene sharing:

(show all 28)
idCompoundScoreTop Affiliating Genes
1anticodon4310.2KARS, GARS
2hydroxylysine4310.1CHKB, SFTPD
3aminoacyl-trna4310.0GARS, IARS, KARS
4trna439.9GARS, IARS, KARS
5fitc439.7CCR7, CD59
6mannan439.7SFTPD, IL17A
7Adenosine monophosphate24 1210.7HARS, KARS, IARS, GARS
8phosphoric acid43 2410.7GARS, IARS, KARS, HARS
9pyrophosphate43 2410.7GARS, IARS, KARS, HARS
10nickel43 2410.6IL17A, CCR7
11latex439.6CHKB, CCR7, CNTN2
12ccl443 2810.4IL17A, CCR7
13endotoxin439.4IL17A, CHKB, SFTPD
14tacrolimus43 49 1211.4CHKB, CCR7, IL17A
15Adenosine triphosphate24 1210.3HARS, KARS, CHKB, IARS, GARS
16phospholipid439.2SFTPD, CHKB, CD59
17glutamate439.2KARS, CHKB, CNTN2, GARS
18leucine439.1SFTPD, KARS, CHKB, CNTN2, GARS
19alanine439.0KARS, CHKB, CCR7, CNTN2, GARS
20cysteine439.0SFTPD, KARS, CHKB, CNTN2, GARS
21thymidine43 2410.0CNTN2, IL17A, CHKB, SFTPD
22steroid438.9CNTN2, IL17A, CHKB, SFTPD
23cyclosporin a43 28 5910.8CD59, CNTN2, IL17A, CHKB
24phosphatidylinositol438.8CD59, IL17A, CCR7, SFTPD
25atp43 289.7CHKB, IARS, GARS, CD59
26oxygen43 249.7CD59, CNTN2, CHKB, SFTPD
27tyrosine438.2CD59, GARS, CNTN2, IL17A, CCR7
28calcium43 49 24 1211.1SFTPD, KARS, CHKB, CCR7, CNTN2, GARS

GO Terms for genes affiliated with Polymyositis

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Cellular components related to Polymyositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear exosome (RNase complex)GO:00001769.0EXOSC9, EXOSC10
2exosome (RNase complex)GO:00001788.8EXOSC9, EXOSC10
3cytosolGO:00058298.1KARS, CHKB, IARS, EXOSC9, GARS, HARS

Biological processes related to Polymyositis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1diadenosine tetraphosphate biosynthetic processGO:001596610.0KARS, GARS
2tRNA aminoacylation for protein translationGO:00064189.5GARS, IARS, KARS, HARS
3nuclear polyadenylation-dependent rRNA catabolic processGO:00710359.3EXOSC10, EXOSC9
4nuclear mRNA surveillanceGO:00710289.1EXOSC9, EXOSC10
5nuclear-transcribed mRNA catabolic processGO:00009569.0EXOSC10, EXOSC9
6RNA phosphodiester bond hydrolysis, exonucleolyticGO:00905038.8EXOSC9, EXOSC10
7immune responseGO:00069558.6EXOSC9, IL17A, CCR7
8gene expressionGO:00104678.5HARS, KARS, IARS, EXOSC9, GARS

Molecular functions related to Polymyositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00055249.0GARS, IARS, CHKB, KARS, HARS
2exoribonuclease activityGO:00045328.8EXOSC9, EXOSC10

Products for genes affiliated with Polymyositis

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Sources for Polymyositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet